ES441470A1 - Obtaining procedure of 1- (2-hydroxymethyl-1-fenoxy) -2-pharmacologically active propanolamines. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for obtaining pharmacologically active 1- (2-hydroxymethyl-1-phenoxy) -2-propanolamines, which correspond to the general formula: ** (see formula) ** Wherein the radicals that are attached to the amino nitrogen are: (see graphic) Whose process is characterized in that the reaction is carried out in two stages, in the first stage the salicylic alcohol reacts with aqueous or alcoholic sodium hydroxide, producing its sodium salt, which treated with epichlorohydrin at a temperature ranging from -6º to 60º c. 18 to 22 hours. Then extract with chloroform, acidify the organic layer with acetic acid and then wash with water, until non-acidic ph, dry with anhydrous sodium sulfate or other appropriate desiccant, remove the chloroform under reduced pressure and distill the residue under vacuum, produce 1- (2-hydroxymethyl-1-phenoxy) -2,3-epoxy-propane and, because in a second step, the amine corresponding to each case is added to the glycidyl ether thus obtained, dissolved in ethanol, methanol or tetrahydrofuran. (Machine-translation by Google Translate, not legally binding)