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EP3329942A3 - Quantum dots for diagnostic imaging - Google Patents

Quantum dots for diagnostic imagingDownload PDF

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Publication number
EP3329942A3
EP3329942A3EP18152632.8AEP18152632AEP3329942A3EP 3329942 A3EP3329942 A3EP 3329942A3EP 18152632 AEP18152632 AEP 18152632AEP 3329942 A3EP3329942 A3EP 3329942A3
Authority
EP
European Patent Office
Prior art keywords
patient
quantum dot
analyte
quantum dots
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP18152632.8A
Other languages
German (de)
French (fr)
Other versions
EP3329942A2 (en
Inventor
Nathalie GRESTY
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nanoco Technologies Ltd
Original Assignee
Nanoco Technologies Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanoco Technologies LtdfiledCriticalNanoco Technologies Ltd
Publication of EP3329942A2publicationCriticalpatent/EP3329942A2/en
Publication of EP3329942A3publicationCriticalpatent/EP3329942A3/en
Withdrawnlegal-statusCriticalCurrent

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Abstract

Methods for detecting disease in a patient are disclosed. The methods involve administering to the patient a quantum dot-analyte conjugate, which includes an analyte that binds to a marker for the disease in the patient's gastrointestinal tract. The analyte is conjugated to a quantum dot having a characteristic emission wavelength. Using an endoscopic modality, a physician can illuminate portions of the patient's gastrointestinal tract and detect the presence of the marker based on emission of the quantum dot. Also disclosed are methods of predicting a response to a treatment in a patient.
EP18152632.8A2013-03-152014-03-14Quantum dots for diagnostic imagingWithdrawnEP3329942A3 (en)

Applications Claiming Priority (3)

Application NumberPriority DateFiling DateTitle
US201361798753P2013-03-152013-03-15
PCT/IB2014/001198WO2014140920A2 (en)2013-03-152014-03-14Quantum dots for diagnostic imaging
EP14747122.1AEP2968616A2 (en)2013-03-152014-03-14Quantum dots for diagnostic imaging

Related Parent Applications (1)

Application NumberTitlePriority DateFiling Date
EP14747122.1ADivisionEP2968616A2 (en)2013-03-152014-03-14Quantum dots for diagnostic imaging

Publications (2)

Publication NumberPublication Date
EP3329942A2 EP3329942A2 (en)2018-06-06
EP3329942A3true EP3329942A3 (en)2018-10-17

Family

ID=51263434

Family Applications (2)

Application NumberTitlePriority DateFiling Date
EP14747122.1AWithdrawnEP2968616A2 (en)2013-03-152014-03-14Quantum dots for diagnostic imaging
EP18152632.8AWithdrawnEP3329942A3 (en)2013-03-152014-03-14Quantum dots for diagnostic imaging

Family Applications Before (1)

Application NumberTitlePriority DateFiling Date
EP14747122.1AWithdrawnEP2968616A2 (en)2013-03-152014-03-14Quantum dots for diagnostic imaging

Country Status (7)

CountryLink
US (2)US20140271486A1 (en)
EP (2)EP2968616A2 (en)
JP (2)JP6147878B2 (en)
KR (2)KR20150121129A (en)
CN (1)CN105188770A (en)
HK (1)HK1212622A1 (en)
WO (1)WO2014140920A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
KR20150121129A (en)*2013-03-152015-10-28나노코 테크놀로지스 리미티드Quantum Dots for Diagnostic Imaging

Citations (5)

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WO2007075179A2 (en)*2005-02-182007-07-05The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human ServicesBacteriophage-quantum dot (phage-qd) nanocomplex to detect biological targets in clinical and environmental isolates
WO2009045579A2 (en)*2007-06-142009-04-09The Regents Of The University Of CaliforniaMultimodal imaging probes for in vivo targeted and non-targeted imaging and therapeutics
EP2270202A1 (en)*2009-07-032011-01-05John IkonomopoulosMycobacterial detection
EP2437061A1 (en)*2010-09-302012-04-04Ikonomopoulos, JohnMycobacterial protein detection

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US20080118941A1 (en)*2004-09-022008-05-22The Regents Of The University Of CaliforniaSignal Peptide-Semiconductor Nanocrystal Conjugates
WO2008008349A2 (en)*2006-07-112008-01-17Drexel UniversityMethods of quantitatively assessing inflammation with biosensing nanoparticles
GB0813273D0 (en)2008-07-192008-08-27Nanoco Technologies LtdMethod for producing aqueous compatible nanoparticles
GB0814458D0 (en)*2008-08-072008-09-10Nanoco Technologies LtdSurface functionalised nanoparticles
US9109249B2 (en)*2011-05-192015-08-18University Of Central Florida Research Foundation, Inc.Microbe detection via hybridizing magnetic relaxation nanosensors
JP5945882B2 (en)*2011-07-222016-07-05東芝メディカルシステムズ株式会社 Marking capsule and capsule endoscope system
KR20150121129A (en)*2013-03-152015-10-28나노코 테크놀로지스 리미티드Quantum Dots for Diagnostic Imaging

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US20060275310A1 (en)*2004-09-302006-12-07Nano Science Diagnostics, Inc.Method and detection and decontamination of antigens by nanoparticle-raman spectroscopy
WO2007075179A2 (en)*2005-02-182007-07-05The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human ServicesBacteriophage-quantum dot (phage-qd) nanocomplex to detect biological targets in clinical and environmental isolates
WO2009045579A2 (en)*2007-06-142009-04-09The Regents Of The University Of CaliforniaMultimodal imaging probes for in vivo targeted and non-targeted imaging and therapeutics
EP2270202A1 (en)*2009-07-032011-01-05John IkonomopoulosMycobacterial detection
EP2437061A1 (en)*2010-09-302012-04-04Ikonomopoulos, JohnMycobacterial protein detection

Non-Patent Citations (14)

* Cited by examiner, † Cited by third party
Title
BRIAN C. WILSON: "Detection and treatment of dysplasia in Barrett's esophagus: a pivotal challenge in translating biophotonics from bench to bedside", JOURNAL OF BIOMEDICAL OPTICS, vol. 12, no. 5, 2007 - 1 November 2007 (2007-11-01), pages 051401-1 - 51401-22, XP040250512, DOI: 10.1117/1.2795688*
DACOSTA RALPH S ET AL: "Multiplexed quantum dot fluorescence Imaging by in vivo targeting of epidermal growth factor receptor (EGFr) and villin expression in Barrett's Esophagus (BE) surgically induced by duodenoesophageal reflux in rats.", GASTROENTEROLOGY, vol. 128, no. 4, Suppl. 2, April 2005 (2005-04-01), & ANNUAL MEETING OF THE AMERICAN-GASTROENTEROLOGICAL-ASSOCIATION/DIGESTIVE-DISEASE-WEEK; CHICAGO, IL, USA; MAY 14 -19, 2005, pages A51, XP002779784, ISSN: 0016-5085*
DWARAKANATH S ET AL: "Quantum dot-antibody and aptamer conjugates shift fluorescence upon binding bacteria", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 325, no. 3, 17 December 2004 (2004-12-17), pages 739 - 743, XP004635487, ISSN: 0006-291X, DOI: 10.1016/J.BBRC.2004.10.099*
ERIC L SNYDER ET AL: "Identification of CD44v6+/CD24- breast carcinoma cells in primary human tumors by quantum dot-conjugated antibodies", LABORATORY INVESTIGATION, vol. 89, no. 8, 1 June 2009 (2009-06-01), pages 857 - 866, XP055120632, ISSN: 0023-6837, DOI: 10.1038/labinvest.2009.54*
GAO X ET AL: "In vivo targeting and imaging with semiconductuor quantum dots", NATURE BIOTECHNOLOGY, vol. 22, no. 8, 18 July 2004 (2004-07-18), pages 969 - 976, XP002399233, ISSN: 1087-0156, DOI: 10.1038/NBT994*
KARWA A ET AL: "Imaging biomarkers of inflammation in situ with functionalized quantum dots in the dextran sodium sulfate (DSS) model of mouse colitis", INFLAMMATION RESEARCH, vol. 56, no. 12, 21 December 2007 (2007-12-21), pages 502 - 510, XP019578154, ISSN: 1420-908X*
KARWA AMOLKUMAR ET AL: "Quantum detection of inflammatory markers in vivo in DSS model of colitis", GASTROENTEROLOGY, vol. 130, no. 4, Suppl. 2, M1149, April 2006 (2006-04-01), & DIGESTIVE DISEASE WEEK MEETING/107TH ANNUAL MEETING OF THE AMERICAN-GASTROENTEROLOGICAL-ASSOCIATION; LOS ANGELES, CA, USA; MAY 19 -24, 2006, pages A312, XP002732464, ISSN: 0016-5085*
LEEVY W M ET AL: "Quantum dot probes for bacteria distinguish Escherichia coli mutants and permit in vivo imaging", CHEMICAL COMMUNICATIONS, vol. 28, no. 20, 28 May 2008 (2008-05-28), pages 2331 - 2333, XP002754090, ISSN: 1359-7345, [retrieved on 20080410], DOI: 10.1039/B803590C*
LIANG YUAN ET AL: "Polymer-Functionalized Silica Nanosphere Labels for Ultrasensitive Detection of Tumor Necrosis Factor-alpha", ANALYTICAL CHEMISTRY, vol. 83, no. 17, 1 September 2011 (2011-09-01), pages 6800 - 6809, XP055152586, ISSN: 0003-2700, DOI: 10.1021/ac201558w*
N. I. CHALMERS ET AL: "Use of Quantum Dot Luminescent Probes To Achieve Single-Cell Resolution of Human Oral Bacteria in Biofilms", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 73, no. 2, 2007, pages 630 - 636, XP055504258, ISSN: 0099-2240, DOI: 10.1128/AEM.02164-06*
PARMESWARAN DIAGARADJANE ET AL.: "EGF-conjugated Near-infrared Quantum dots as nanoprobes for in-vivo Imaging of EGFR expression", PROC. OF SPIE, vol. 6866, 2008, pages 68660R-1 - 68660R-9, XP040433288, DOI: 10.1117/12.763985*
RUAN JING ET AL: "HER2 monoclonal antibody conjugated RNase-A-associated CdTe quantum dots for targeted imaging and therapy of gastric cancer", BIOMATERIALS, vol. 33, no. 29, 12 July 2012 (2012-07-12), pages 7093 - 7102, XP028932425, ISSN: 0142-9612, DOI: 10.1016/J.BIOMATERIALS.2012.06.053*
S DWARAKANATHA ET AL: "Antibody-quantum dot conjugates exhibit enhanced antibacterial effect vs. unconjugated quantum dots", FOLIA MICROBIOLOGICA, vol. 52, no. 1, 2007, pages 31 - 34, XP055152494, ISSN: 0015-5632, DOI: 10.1007/BF02932134*
VASUDEVANPILLAI BIJU ET AL: "Delivering quantum dots to cells: bioconjugated quantum dots for targeted and nonspecific extracellular and intracellular imaging", CHEMICAL SOCIETY REVIEWS, vol. 39, no. 8, 2010, pages 3031 - 3056, XP055031355, ISSN: 0306-0012, DOI: 10.1039/b926512k*

Also Published As

Publication numberPublication date
WO2014140920A3 (en)2015-05-14
WO2014140920A2 (en)2014-09-18
KR20150121129A (en)2015-10-28
US20180117184A1 (en)2018-05-03
EP2968616A2 (en)2016-01-20
JP2016517403A (en)2016-06-16
KR20170121314A (en)2017-11-01
CN105188770A (en)2015-12-23
US20140271486A1 (en)2014-09-18
JP6147878B2 (en)2017-06-14
JP6456433B2 (en)2019-01-23
EP3329942A2 (en)2018-06-06
HK1212622A1 (en)2016-06-17
JP2017149771A (en)2017-08-31

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