EP2007379A4 - Nanoelectronic detection of biomolecules employing analyte amplification and reporters - Google Patents

Nanoelectronic detection of biomolecules employing analyte amplification and reporters

Info

Publication number: EP2007379A4
Authority: EP; European Patent Office
Prior art keywords: nanoelectronic; reporters; biomolecules; detection; analyte amplification
Prior art date: 2006-04-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Other versions

Inventor

Eugene Tu

Christian Valcke

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Nanomix Inc

Original Assignee

Nanomix Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-04-04

Filing date

2007-04-03

Publication date

2009-12-09

2006-07-18Priority claimed from US11/488,465external-prioritypatent/US20070045756A1/en

2006-10-26Priority claimed from US11/588,845external-prioritypatent/US20080021339A1/en

2007-04-03Application filed by Nanomix IncfiledCriticalNanomix Inc

2008-12-31Publication of EP2007379A2publicationCriticalpatent/EP2007379A2/en

2009-12-09Publication of EP2007379A4publicationCriticalpatent/EP2007379A4/en

StatusWithdrawnlegal-statusCriticalCurrent

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6825—Nucleic acid detection involving sensors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/682—Signal amplification
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6823—Release of bound markers
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0645—Electrodes
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5029—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures using swabs

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Analytical Chemistry (AREA)
Microbiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Biotechnology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Physics & Mathematics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Apparatus Associated With Microorganisms And Enzymes (AREA)
Investigating Or Analysing Biological Materials (AREA)

EP07754869A2006-04-042007-04-03Nanoelectronic detection of biomolecules employing analyte amplification and reportersWithdrawnEP2007379A4 (en)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
US78902206P	2006-04-04	2006-04-04
US11/488,465US20070045756A1 (en)	2002-09-04	2006-07-18	Nanoelectronic sensor with integral suspended micro-heater
US85021706P	2006-10-06	2006-10-06
US11/588,845US20080021339A1 (en)	2005-10-27	2006-10-26	Anesthesia monitor, capacitance nanosensors and dynamic sensor sampling method
US90153807P	2007-02-14	2007-02-14
PCT/US2007/008422WO2007114931A2 (en)	2006-04-04	2007-04-03	Nanoelectronic detection of biomolecules employing analyte amplification and reporters

Publications (2)

Publication Number	Publication Date
EP2007379A2 EP2007379A2 (en)	2008-12-31
EP2007379A4true EP2007379A4 (en)	2009-12-09

Family

ID=38564139

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP07754869AWithdrawnEP2007379A4 (en)	2006-04-04	2007-04-03	Nanoelectronic detection of biomolecules employing analyte amplification and reporters

Country Status (3)

Country	Link
EP (1)	EP2007379A4 (en)
JP (1)	JP2009532064A (en)
WO (1)	WO2007114931A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8154093B2 (en)	2002-01-16	2012-04-10	Nanomix, Inc.	Nano-electronic sensors for chemical and biological analytes, including capacitance and bio-membrane devices
US8152991B2 (en)	2005-10-27	2012-04-10	Nanomix, Inc.	Ammonia nanosensors, and environmental control system
US7547931B2 (en)	2003-09-05	2009-06-16	Nanomix, Inc.	Nanoelectronic capnometer adaptor including a nanoelectric sensor selectively sensitive to at least one gaseous constituent of exhaled breath
US7714398B2 (en)	2002-09-05	2010-05-11	Nanomix, Inc.	Nanoelectronic measurement system for physiologic gases and improved nanosensor for carbon dioxide
US7522040B2 (en)	2004-04-20	2009-04-21	Nanomix, Inc.	Remotely communicating, battery-powered nanostructure sensor devices
US7948041B2 (en)	2005-05-19	2011-05-24	Nanomix, Inc.	Sensor having a thin-film inhibition layer
CN102471051B (en)	2009-08-07	2014-06-11	纳诺米克斯公司	Magnetic carbon nanotube based biodetection
EP2989569B1 (en)	2013-04-24	2021-06-23	Fresenius Kabi Deutschland GmbH	Method of operating a control device for controlling an infusion device

Citations (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030036065A1 (en)*	2001-08-17	2003-02-20	Robert Gellibolian	Method and system for array signal generation and amplification
US20040214176A1 (en)*	2003-04-22	2004-10-28	Osborne James C.	Multiplexed DNA assays using structure-specific endonucleases
US20050003355A1 (en)*	2002-04-22	2005-01-06	Manchun Lu	Single nucleotide polymorphism analysis using surface invasive cleavage reactions
WO2005047468A2 (en)*	2003-11-06	2005-05-26	University Of Nevada, Reno	Improved methods for detecting and measuring specific nucleic acid sequences
WO2006024023A2 (en)*	2004-08-24	2006-03-02	Nanomix, Inc.	Nanotube sensor devices for dna detection
WO2006071895A2 (en)*	2004-12-28	2006-07-06	Nanomix, Inc.	Nanoelectronic devices for dna detection, and recognition of polynucleotide sequences

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JP3778925B2 (en)*	1993-01-15	2006-05-24	ザパブリックヘルスリサーチインスティチュートオブザシティーオブニューヨークインク	High sensitivity nucleic acid sandwich hybridization assay and kit
US5985557A (en)*	1996-01-24	1999-11-16	Third Wave Technologies, Inc.	Invasive cleavage of nucleic acids
CA2274587A1 (en)*	1996-12-10	1998-06-18	Genetrace Systems Inc.	Releasable nonvolatile mass-label molecules
US7118860B2 (en)*	1999-10-29	2006-10-10	Stratagene California	Methods for detection of a target nucleic acid by capture
US20050250094A1 (en)*	2003-05-30	2005-11-10	Nanosphere, Inc.	Method for detecting analytes based on evanescent illumination and scatter-based detection of nanoparticle probe complexes

2007
- 2007-04-03EPEP07754869Apatent/EP2007379A4/ennot_activeWithdrawn
- 2007-04-03JPJP2009504284Apatent/JP2009532064A/enactivePending
- 2007-04-03WOPCT/US2007/008422patent/WO2007114931A2/enactiveApplication Filing

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030036065A1 (en)*	2001-08-17	2003-02-20	Robert Gellibolian	Method and system for array signal generation and amplification
US20050003355A1 (en)*	2002-04-22	2005-01-06	Manchun Lu	Single nucleotide polymorphism analysis using surface invasive cleavage reactions
US20040214176A1 (en)*	2003-04-22	2004-10-28	Osborne James C.	Multiplexed DNA assays using structure-specific endonucleases
WO2005047468A2 (en)*	2003-11-06	2005-05-26	University Of Nevada, Reno	Improved methods for detecting and measuring specific nucleic acid sequences
WO2006024023A2 (en)*	2004-08-24	2006-03-02	Nanomix, Inc.	Nanotube sensor devices for dna detection
WO2006071895A2 (en)*	2004-12-28	2006-07-06	Nanomix, Inc.	Nanoelectronic devices for dna detection, and recognition of polynucleotide sequences

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BAEUMNER A J ET AL: "A Universal Nucleic Acid Sequence Biosensor with Nanomolar Detection Limits", ANALYTICAL CHEMISTRY 20040215 AMERICAN CHEMICAL SOCIETY US, vol. 76, no. 4, 1 January 2004 (2004-01-01), pages 888 - 894, XP002551933*
DUCK ET AL: "PROBE AMPLIFIER SYSTEM BASED ON CHIMERIC CYCLING OLIGONUCLEOTIDES", BIOTECHNIQUES, NATICK, MA, US, vol. 9, no. 2, 1 January 1990 (1990-01-01), pages - 147, XP000406092*
GOODRICH TERRY T ET AL: "Direct detection of genomic DNA by enzymatically amplified SPR imaging measurements of RNA microarrays", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 126, no. 13, 7 April 2004 (2004-04-07), pages 4086 - 4087, XP002551932, ISSN: 0002-7863*
LEE H J ET AL: "Enzymatically amplified surface plasmon resonance imaging detection of DNA by exonuclease III digestion of DNA microarrays", ANALYTICAL CHEMISTRY 20050815 AMERICAN CHEMICAL SOCIETY US, vol. 77, no. 16, 15 August 2005 (2005-08-15), pages 5096 - 5100, XP002551931*

Also Published As

Publication number	Publication date
JP2009532064A (en)	2009-09-10
EP2007379A2 (en)	2008-12-31
WO2007114931A2 (en)	2007-10-11
WO2007114931A3 (en)	2008-12-24

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EP1931979A4 (en)	2010-01-06	Microfluidic detection of analytes
GB0607205D0 (en)	2006-05-17	Miniaturised biosensor with optimized anperimetric detection
BRPI0715346A2 (en)	2013-11-26	ANALYTE AND NUCLEIC ACID DETECTION
DE602006008371D1 (en)	2009-09-24	Connection detection connector and connection detection connector assembly
GB0701641D0 (en)	2007-03-07	Analyte manipulation and detection
EP1952334A4 (en)	2011-06-08	Detection of intra-firm matching and response thereto
EP2007379A4 (en)	2009-12-09	Nanoelectronic detection of biomolecules employing analyte amplification and reporters
DK2069439T3 (en)	2015-01-12	Nanocomposite particle and process for its preparation
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DE602006019275D1 (en)	2011-02-10	NITRITE DETECTION TECHNOLOGY
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BRPI0810515A2 (en)	2014-10-21	ANALYZED METHODS AND SENSORS WITHOUT CALIBRATION
GB0616508D0 (en)	2006-09-27	Analyte manipulation and detection
DE602006018050D1 (en)	2010-12-16	DIRECTED AUDIO DETECTION
GB0600927D0 (en)	2006-02-22	Assay and materials therefor
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DE602006001781D1 (en)	2008-08-28	Connector and connector assembly
EP1864329A4 (en)	2014-07-02	Methods and systems for detecting presence of materials
GB0616230D0 (en)	2006-09-27	Biomarkers and uses thereof
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GB0617730D0 (en)	2006-10-18	Analyte detection
DE602006001091D1 (en)	2008-06-19	Connector and connector assembly

Legal Events

Date	Code	Title	Description
2008-11-28	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text:ORIGINAL CODE: 0009012
2008-12-31	17P	Request for examination filed	Effective date:20081103
2008-12-31	AK	Designated contracting states	Kind code of ref document:A2 Designated state(s):AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR
2008-12-31	AX	Request for extension of the european patent	Extension state:AL BA HR MK RS
2009-02-04	R17D	Deferred search report published (corrected)	Effective date:20081224
2009-02-11	RIC1	Information provided on ipc code assigned before grant	Ipc:C12Q 1/68 20060101AFI20090107BHEP
2009-12-09	A4	Supplementary search report drawn up and despatched	Effective date:20091110
2010-04-07	17Q	First examination report despatched	Effective date:20100305
2011-02-18	STAA	Information on the status of an ep patent application or granted ep patent	Free format text:STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2011-03-23	18D	Application deemed to be withdrawn	Effective date:20100916

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