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| US75344805P | 2005-12-22 | 2005-12-22 | |
| PCT/US2006/048250WO2007075572A2 (en) | 2005-12-22 | 2006-12-18 | Orally active purine-based inhibitors of heat shock protein 90 |
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| EP06845721AWithdrawnEP1962863A4 (en) | 2005-12-22 | 2006-12-18 | Orally active purine-based inhibitors of heat shock protein 90 |
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| AU (1) | AU2006331917A1 (en) |
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| WO (1) | WO2007075572A2 (en) |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2652263A1 (en)* | 2006-05-12 | 2007-11-22 | Myriad Genetics, Inc. | Therapeutic compounds and their use in cancer |
| ES2430217T3 (en)* | 2007-03-20 | 2013-11-19 | Curis, Inc. | Condensed aminopyridine as HSP90 inhibitors |
| JP2011503206A (en)* | 2007-11-14 | 2011-01-27 | ミレクシス， インコーポレイテッド | Therapeutic compounds and methods of use thereof in the treatment of diseases and disorders |
| AU2010204608B2 (en) | 2009-01-16 | 2013-12-05 | Curis, Inc. | Fused amino pyridines for the treatment of brain tumors |
| CA2832099C (en) | 2011-04-05 | 2019-07-09 | Sloan-Kettering Institute For Cancer Research | Hsp90 inhibitors |
| CA2832530C (en) | 2011-04-05 | 2021-02-16 | Sloan-Kettering Institute For Cancer Research | Hsp90 inhibitors |
| CA2885259A1 (en) | 2012-10-04 | 2014-04-10 | Pfizer Limited | Pyrrolo[3,2-c]pyridine tropomyosin-related kinase inhibitors |
| EP3033338A4 (en) | 2013-08-16 | 2017-06-14 | Memorial Sloan-Kettering Cancer Center | Selective grp94 inhibitors and uses thereof |
| CN109721499A (en)* | 2018-12-19 | 2019-05-07 | 南京杰科丰环保技术装备研究院有限公司 | A kind of nitrotoleune adds hydrogen to prepare the preparation method of methylaniline |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003037860A2 (en)* | 2001-10-30 | 2003-05-08 | Conforma Therapeutics Corporation | Purine analogs having hsp90-inhibiting activity |
| US20040102458A1 (en)* | 2000-11-02 | 2004-05-27 | Gabriela Chiosis | Small molecule compositions for binding to hsp90 |
| WO2006084030A2 (en)* | 2005-02-01 | 2006-08-10 | Sloan-Kettering Institute For Cancer Research | Small-molecule hsp90 inhibitors |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4971972A (en)* | 1989-03-23 | 1990-11-20 | Schering Corporation | Phosphodiesterase inhibitors having an optionally substituted purine derivative portion and a benzo- or cyclopenta-furan portion |
| US7129239B2 (en)* | 2002-10-28 | 2006-10-31 | Pfizer Inc. | Purine compounds and uses thereof |
| EP2145888A1 (en)* | 2003-09-18 | 2010-01-20 | Conforma Therapeutics Corporation | Deazapurine derivatives as HSP90-Inhibitors |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040102458A1 (en)* | 2000-11-02 | 2004-05-27 | Gabriela Chiosis | Small molecule compositions for binding to hsp90 |
| WO2003037860A2 (en)* | 2001-10-30 | 2003-05-08 | Conforma Therapeutics Corporation | Purine analogs having hsp90-inhibiting activity |
| US20050049263A1 (en)* | 2001-10-30 | 2005-03-03 | Kasibhatla Srinivas Rao | Purine analogs having hsp90-inhibiting activity |
| WO2006084030A2 (en)* | 2005-02-01 | 2006-08-10 | Sloan-Kettering Institute For Cancer Research | Small-molecule hsp90 inhibitors |
| Title |
|---|
| L. LLAUGER ET AL.: "Evaluation of 8-Arylsulfany, 8-Arylsulfoxyl, and 8-Arylsulfonyl Adenine Derivatives as Inhibitors of the Heat Shock Protein 90", J. MED. CHEM., vol. 48, no. 8, 25 March 2005 (2005-03-25), pages 2892 - 2905, XP002602270* |
| M. A. BIAMONTE ET AL.: "Preparation of 8-(Arylsulfanyl)adenines with Diazonium Salts under Mild, Aerobic Conditions", J. ORG. CHEM., vol. 70, no. 2, 21 December 2004 (2004-12-21), pages 717 - 720, XP002602397* |
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| EP1962863A2 (en) | 2008-09-03 |
| WO2007075572A3 (en) | 2009-05-07 |
| JP2009521446A (en) | 2009-06-04 |
| AU2006331917A1 (en) | 2007-07-05 |
| WO2007075572A2 (en) | 2007-07-05 |
| CA2634723A1 (en) | 2007-07-05 |
| Publication | Publication Date | Title |
|---|---|---|
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| RIN1 | Information on inventor provided before grant (corrected) | Inventor name:SHI, JIANDONG Inventor name:BIAMONTE, MARCO Inventor name:HONG, KEVIN D. Inventor name:FAN, JUNHUA Inventor name:BOEHM, MARCUS F. Inventor name:ZHANG, LIN Inventor name:KASIBHATLA, SRINIVAS R. | |
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| RIC1 | Information provided on ipc code assigned before grant | Ipc:C07D 473/00 20060101ALI20090623BHEP Ipc:A61K 31/675 20060101AFI20090623BHEP | |
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