EP1581261A4 - Cytotoxins and diagnostic imaging agents comprising hsp90 ligands - Google Patents

Cytotoxins and diagnostic imaging agents comprising hsp90 ligands

Info

Publication number: EP1581261A4
Authority: EP; European Patent Office
Prior art keywords: cytotoxins; diagnostic imaging; imaging agents; hsp90 ligands; hsp90
Prior art date: 2002-12-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Other versions

Inventor

Adeela Kamal

Francis Burrows

Lin Zhang

Marcus Boehm

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Conforma Therapeutics Corp

Original Assignee

Conforma Therapeutics Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-12-12

Filing date

2003-06-12

Publication date

2009-10-21

2002-12-12Priority claimed from PCT/US2002/039993external-prioritypatent/WO2003050295A2/en

2003-06-12Application filed by Conforma Therapeutics CorpfiledCriticalConforma Therapeutics Corp

2005-10-05Publication of EP1581261A1publicationCriticalpatent/EP1581261A1/en

2009-10-21Publication of EP1581261A4publicationCriticalpatent/EP1581261A4/en

StatusWithdrawnlegal-statusCriticalCurrent

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D225/06—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/5532—Seven-(or more) membered rings
- C07F9/5535—Seven-(or more) membered rings condensed with carbocyclic rings or ring systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Physics & Mathematics (AREA)
Optics & Photonics (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

EP03741983A2002-12-122003-06-12Cytotoxins and diagnostic imaging agents comprising hsp90 ligandsWithdrawnEP1581261A4 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
WOPCT/US02/39993		2002-12-12
PCT/US2002/039993WO2003050295A2 (en)	2001-12-12	2002-12-12	Assays and implements for determining and modulating hsp90 binding activity
PCT/US2003/018776WO2004054624A1 (en)	2002-12-12	2003-06-12	Cytotoxins and diagnostic imaging agents comprising hsp90 ligands

Publications (2)

Publication Number	Publication Date
EP1581261A1 EP1581261A1 (en)	2005-10-05
EP1581261A4true EP1581261A4 (en)	2009-10-21

Family

ID=32592278

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP03741983AWithdrawnEP1581261A4 (en)	2002-12-12	2003-06-12	Cytotoxins and diagnostic imaging agents comprising hsp90 ligands

Country Status (4)

Country	Link
EP (1)	EP1581261A4 (en)
AU (1)	AU2003303058A1 (en)
CA (1)	CA2549463A1 (en)
WO (1)	WO2004054624A1 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7649006B2 (en)	2002-08-23	2010-01-19	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto and analogues thereof
US6921769B2 (en)	2002-08-23	2005-07-26	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto and analogues thereof
PT1506203E (en)	2002-08-23	2007-04-30	Sloan Kettering Inst Cancer	Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US20050020556A1 (en)*	2003-05-30	2005-01-27	Kosan Biosciences, Inc.	Method for treating diseases using HSP90-inhibiting agents in combination with platinum coordination complexes
US7691838B2 (en)	2003-05-30	2010-04-06	Kosan Biosciences Incorporated	Method for treating diseases using HSP90-inhibiting agents in combination with antimitotics
GB0526615D0 (en)*	2005-12-30	2006-02-08	Novartis Ag	Organic compounds
GB0603880D0 (en)*	2006-02-27	2006-04-05	Novartis Ag	Organic compounds
CN100519536C (en)*	2006-03-21	2009-07-29	中国医学科学院医药生物技术研究所	Group of geldanamycin derivative with nucleoside base
KR20100074177A (en)	2007-09-10	2010-07-01	유니버시티 오브 매사추세츠	Mitochondria-targeted anti-tumour agents
US20110270151A1 (en)*	2008-09-08	2011-11-03	The Methodist Hospital Research Institute	Image-guided energy deposition for targeted drug delivery
US20140079636A1 (en)	2012-04-16	2014-03-20	Dinesh U. Chimmanamada	Targeted therapeutics
WO2015038649A1 (en)	2013-09-10	2015-03-19	Synta Pharmaceuticals Corp.	Targeted therapeutics
WO2015066053A2 (en)	2013-10-28	2015-05-07	Synta Pharmaceuticals Corp.	Targeted therapeutics
JP2017505777A (en)	2014-01-29	2017-02-23	シンタファーマスーティカルズコーポレーション	Targeted therapeutics
CA2941618A1 (en)	2014-03-03	2015-09-11	Synta Pharmaceuticals Corp.	Targeted therapeutics
MA39483A (en)	2014-03-18	2015-09-24	Synta Pharmaceuticals Corp	TARGET THERAPEUTIC AGENTS
CN110799194A (en)	2017-06-20	2020-02-14	马德里加尔制药公司	Combination therapy comprising targeted therapeutic agents
CA3067572A1 (en)	2017-06-20	2018-12-27	Madrigal Pharmaceuticals, Inc.	Targeted therapeutics

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2000003737A2 (en)*	1998-07-17	2000-01-27	The United States Of America, Represented By The Secretary, Department Of Health And Human Services	Water-soluble drugs and methods for their production
WO2003045319A2 (en)*	2001-11-21	2003-06-05	Activbiotics, Inc.	Targeted therapeutics and uses thereof

2003
- 2003-06-12AUAU2003303058Apatent/AU2003303058A1/ennot_activeAbandoned
- 2003-06-12WOPCT/US2003/018776patent/WO2004054624A1/ennot_activeApplication Discontinuation
- 2003-06-12EPEP03741983Apatent/EP1581261A4/ennot_activeWithdrawn
- 2003-06-12CACA002549463Apatent/CA2549463A1/ennot_activeAbandoned

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2000003737A2 (en)*	1998-07-17	2000-01-27	The United States Of America, Represented By The Secretary, Department Of Health And Human Services	Water-soluble drugs and methods for their production
WO2003045319A2 (en)*	2001-11-21	2003-06-05	Activbiotics, Inc.	Targeted therapeutics and uses thereof

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ABSTRACTS OF PAPERS AMERICAN CHEMICAL SOCIETY, vol. 224, no. 1-2, 2002, 224TH NATIONAL MEETING OF THE AMERICAN CHEMICAL SOCIETY; BOSTON, MA, USA; AUGUST 18-22, 2002, pages BIOT 64, ISSN: 0065-7727*
CHIOSIS GABRIELA ET AL: "A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells", CHEMISTRY AND BIOLOGY, vol. 8, no. 3, March 2001 (2001-03-01), LONDON, pages 289 - 299, XP002542023, ISSN: 1074-5521*
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 2002, MANDLER RAYA ET AL: "Strategies in conjugating geldanamycin derivatives to monoclonal antibodies that enhance herceptin efficacy in mice bearing HER2-overexpressing xenografts", XP002542020, Database accession no. PREV200200490291*
FUKAZAWA H ET AL: "Labeling of v-Src and BCR-ABL tyrosine kinases with [<14>C]herbimycin A and its use in the elucidation of the kinase inactivation mechanism", FEBS LETTERS, vol. 340, no. 3, 1994, NL, pages 155 - 158, XP002542022, ISSN: 0014-5793*
MANDLER R ET AL: "Synthesis and evaluation of antiproliferative activity of a geldanamycin-Herceptin TM immunoconjugate", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 10, no. 10, 1 May 2000 (2000-05-01), PERGAMON, ELSEVIER SCIENCE, GB, pages 1025 - 1028, XP004204597, ISSN: 0960-894X*
SCHNUR R C ET AL: "Preparation of 17-amino-22-(4'-azido-3'-<125>iodophenacyl)-17- demethoxygeldanamycin (1): An ansamycin for photoaffinity labeling", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. 34, no. 6, 1994, GB, pages 529 - 536, XP002542021, ISSN: 0362-4803*
See also references ofWO2004054624A1*

Also Published As

Publication number	Publication date
AU2003303058A1 (en)	2004-07-09
WO2004054624A1 (en)	2004-07-01
EP1581261A1 (en)	2005-10-05
CA2549463A1 (en)	2004-07-01

Publication	Publication Date	Title
EP1581261A4 (en)	2009-10-21	Cytotoxins and diagnostic imaging agents comprising hsp90 ligands
GB0009179D0 (en)	2000-05-31	Non-invasive prenatal diagnosis
EP1372739A4 (en)	2005-10-19	Stabilized therapeutic and imaging agents
EP1637064A4 (en)	2010-07-28	Encapsulated endoscope and encapsulated endoscope system
SI1757606T1 (en)	2009-10-31	Xanthinderivatives for use as medical agents and the preparation thereof
EP1390393A4 (en)	2006-05-24	Pentapeptide compounds and uses related thereto
AU2003282810A8 (en)	2004-05-04	Integrated multi-rail imaging system
EP1572741A4 (en)	2006-09-27	Therapeutic and diagnostic agents
AU2002346086A1 (en)	2003-01-29	Diagnostic imaging tabletop
GB0104690D0 (en)	2001-04-11	Diagnostic test
GB0500198D0 (en)	2005-02-16	Ultrasonic imaging device
GB0126298D0 (en)	2002-01-02	Fault diagnosis
GB2396909B (en)	2005-07-20	Glare-directed imaging
IL153183A0 (en)	2003-06-24	Agents for imaging and diagnostic methods using them
GB2349882B (en)	2004-08-11	Dopamine transporter imaging agents
AU2003245589A8 (en)	2004-01-06	System and method for noninvasive diagnostic imaging
GB9926805D0 (en)	2000-01-12	Diagnostic methods
PT1670762E (en)	2013-02-07	Pyridylacetylenes for use as radiotracers and imaging agents
AU2003274588A8 (en)	2004-06-03	Diagnostic x-ray system
GB0120009D0 (en)	2001-10-10	Cause and effect diagnosis
EP1531852A4 (en)	2006-04-05	Caspase 9 activation and uses therefor
IL150906A0 (en)	2003-02-12	Diagnostic microspheres
GB0200757D0 (en)	2002-02-27	Diagnostic methods
GB9924717D0 (en)	1999-12-22	Diagnostic
IL152631A0 (en)	2003-06-24	Agents for imaging and diagnostic methods using them

Legal Events

Date	Code	Title	Description
2005-08-19	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text:ORIGINAL CODE: 0009012
2005-10-05	17P	Request for examination filed	Effective date:20050706
2005-10-05	AK	Designated contracting states	Kind code of ref document:A1 Designated state(s):AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
2005-10-05	AX	Request for extension of the european patent	Extension state:AL LT LV MK
2006-04-05	DAX	Request for extension of the european patent (deleted)
2006-08-23	RIN1	Information on inventor provided before grant (corrected)	Inventor name:BOEHM, MARCUS Inventor name:ZHANG, LIN Inventor name:BURROWS, FRANCIS Inventor name:KAMAL, ADEELA
2009-10-14	RIC1	Information provided on ipc code assigned before grant	Ipc:A61P 43/00 20060101ALI20090907BHEP Ipc:A61M 36/14 20060101ALI20090907BHEP Ipc:A61K 51/00 20060101AFI20040705BHEP
2009-10-21	A4	Supplementary search report drawn up and despatched	Effective date:20090923
2010-06-04	STAA	Information on the status of an ep patent application or granted ep patent	Free format text:STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2010-07-07	18D	Application deemed to be withdrawn	Effective date:20091223

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