| Application Number | Priority Date | Filing Date | Title | 
|---|---|---|---|
| US34580502P | 2002-01-04 | 2002-01-04 | |
| US345805P | 2002-01-04 | ||
| US37345302P | 2002-04-17 | 2002-04-17 | |
| US373453P | 2002-04-17 | ||
| PCT/US2003/000394WO2003057856A2 (en) | 2002-01-04 | 2003-01-06 | Dominant negative proteins and methods thereof | 
| Publication Number | Publication Date | 
|---|---|
| EP1576088A2 EP1576088A2 (en) | 2005-09-21 | 
| EP1576088A4true EP1576088A4 (en) | 2006-09-06 | 
| Application Number | Title | Priority Date | Filing Date | 
|---|---|---|---|
| EP03705672AWithdrawnEP1576088A4 (en) | 2002-01-04 | 2003-01-06 | Dominant negative proteins and methods thereof | 
| Country | Link | 
|---|---|
| US (2) | US20030166559A1 (en) | 
| EP (1) | EP1576088A4 (en) | 
| JP (1) | JP2005530482A (en) | 
| AU (1) | AU2003207464A1 (en) | 
| CA (1) | CA2472049A1 (en) | 
| WO (1) | WO2003057856A2 (en) | 
| Publication number | Priority date | Publication date | Assignee | Title | 
|---|---|---|---|---|
| US20040230380A1 (en)* | 2002-01-04 | 2004-11-18 | Xencor | Novel proteins with altered immunogenicity | 
| US7381792B2 (en)* | 2002-01-04 | 2008-06-03 | Xencor, Inc. | Variants of RANKL protein | 
| AU2003277828B2 (en)* | 2002-10-29 | 2009-06-04 | Anaphore, Inc. | Trimeric binding proteins for trimeric cytokines | 
| US20060014248A1 (en)* | 2003-01-06 | 2006-01-19 | Xencor, Inc. | TNF super family members with altered immunogenicity | 
| US20050221443A1 (en)* | 2003-01-06 | 2005-10-06 | Xencor, Inc. | Tumor necrosis factor super family agonists | 
| US7553930B2 (en) | 2003-01-06 | 2009-06-30 | Xencor, Inc. | BAFF variants and methods thereof | 
| US20050130892A1 (en)* | 2003-03-07 | 2005-06-16 | Xencor, Inc. | BAFF variants and methods thereof | 
| US9714282B2 (en)* | 2003-09-26 | 2017-07-25 | Xencor, Inc. | Optimized Fc variants and methods for their generation | 
| AU2004283720A1 (en)* | 2003-10-24 | 2005-05-06 | Medtronic, Inc. | Techniques to treat neurological disorders by attenuating the production of pro-inflammatory mediators | 
| CN102977205A (en) | 2004-12-13 | 2013-03-20 | 赛弗隆澳大利亚(Vic)私人有限公司 | Novel osteoprotegerin variant proteins | 
| EP3037544A1 (en) | 2005-10-13 | 2016-06-29 | Human Genome Sciences, Inc. | Methods and compositions for use in treatment of systemic lupus erythematosus (sle) patients with autoantibody positive diseases | 
| EP1854458A1 (en)* | 2006-05-08 | 2007-11-14 | IMBA-Institut für Molekulare Biotechnologie GmbH | Use of a compound with RANKL activity | 
| WO2009120993A2 (en)* | 2008-03-28 | 2009-10-01 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Synthetic analogs of the juxtamembrane domain of igf1r and uses thereof | 
| NZ589086A (en) | 2008-04-11 | 2012-09-28 | Merrimack Pharmaceuticals Inc | Human serum albumin (HSA) linkers and conjugates thereof | 
| USRE48948E1 (en) | 2008-04-18 | 2022-03-01 | Warsaw Orthopedic, Inc. | Clonidine compounds in a biodegradable polymer | 
| WO2010059315A1 (en) | 2008-11-18 | 2010-05-27 | Merrimack Pharmaceuticals, Inc. | Human serum albumin linkers and conjugates thereof | 
| US20100239632A1 (en) | 2009-03-23 | 2010-09-23 | Warsaw Orthopedic, Inc. | Drug depots for treatment of pain and inflammation in sinus and nasal cavities or cardiac tissue | 
| EP2468764A1 (en)* | 2010-12-24 | 2012-06-27 | Rijksuniversiteit te Groningen | TNF family ligand variants | 
| US20150202287A1 (en) | 2012-08-30 | 2015-07-23 | Merrimack Pharmaceuticals, Inc. | Combination therapies comprising anti-erbb3 agents | 
| US9914761B2 (en) | 2014-07-10 | 2018-03-13 | Washington University | Oligomers for TNF superfamily inhibition | 
| KR101576904B1 (en)* | 2014-07-31 | 2015-12-14 | (주)케어젠 | Peptides Having Activities for Inhibiting Differentiation and Activity of Osteoclast and Uses Thereof | 
| US11111284B2 (en) | 2014-08-21 | 2021-09-07 | The General Hospital Corporation | Tumor necrosis factor superfamily and TNF-like ligand muteins and methods of preparing | 
| Publication number | Priority date | Publication date | Assignee | Title | 
|---|---|---|---|---|
| WO2001025277A1 (en)* | 1999-10-07 | 2001-04-12 | Maxygen Aps | Single-chain antagonist polypeptides | 
| WO2001064889A2 (en)* | 2000-03-02 | 2001-09-07 | Xencor | Tnf-alpha variants for the treatment of tnf-alpha related disorders | 
| WO2003033720A2 (en)* | 2001-10-15 | 2003-04-24 | Xencor | Protein based tnf-alpha variants for the treatment of tnf-alpha related disorders | 
| Publication number | Priority date | Publication date | Assignee | Title | 
|---|---|---|---|---|
| US5672347A (en)* | 1984-07-05 | 1997-09-30 | Genentech, Inc. | Tumor necrosis factor antagonists and their use | 
| US5519119A (en)* | 1990-09-21 | 1996-05-21 | Ishihara Sangyo Kaisha Ltd. | Muteins of TNF pharmaceutical compositions and a method of making | 
| US5447851B1 (en)* | 1992-04-02 | 1999-07-06 | Univ Texas System Board Of | Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells | 
| US5573924A (en)* | 1992-09-08 | 1996-11-12 | Immunex Corporation | CD27 ligand | 
| US6177401B1 (en)* | 1992-11-13 | 2001-01-23 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften | Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis | 
| CA2119089A1 (en)* | 1993-03-29 | 1994-09-30 | David Banner | Tumor necrosis factor muteins | 
| JPH08511000A (en)* | 1993-04-06 | 1996-11-19 | フレッド ハッチンソン キャンサー リサーチ センター | Chimeric cytokine receptor in lymphocytes | 
| US5700926A (en)* | 1993-04-27 | 1997-12-23 | Washington University | Molecular cloning of the anhidrotic ectodermal dysplasia gene | 
| US5556786A (en)* | 1993-04-27 | 1996-09-17 | Washington University | Anhidrotic ectodermal dysplasia gene and method of detecting same | 
| DE69740107D1 (en)* | 1996-12-23 | 2011-03-10 | Immunex Corp | RECEPTOR ACTIVATOR OF NF-KAPPA B, RECEPTOR IS A MEMBER OF THE TNF RECEPTOR SUPERFAMILY | 
| US6316408B1 (en)* | 1997-04-16 | 2001-11-13 | Amgen Inc. | Methods of use for osetoprotegerin binding protein receptors | 
| US5843678A (en) | 1997-04-16 | 1998-12-01 | Amgen Inc. | Osteoprotegerin binding proteins | 
| CN1195849C (en) | 1997-09-12 | 2005-04-06 | 阿普泰克R&D公司 | APRIL-novel proteins with growth effect | 
| WO1999029865A2 (en) | 1997-12-12 | 1999-06-17 | The Rockefeller University | A protein belonging to the tnf superfamily, nucleic acids encoding same, and methods of use thereof | 
| EP1075535A4 (en)* | 1998-05-07 | 2006-01-18 | Univ Maryland | METHOD FOR DIAGNOSIS AND TREATMENT OF CHRONIC TAIL PAIN | 
| US6355782B1 (en)* | 1998-07-09 | 2002-03-12 | Baylor College Of Medicine | Hypohidrotic ectodermal dyplasia genes and proteins | 
| HK1040261A1 (en)* | 1998-09-15 | 2002-05-31 | 法麦克萨有限公司 | Method for down-regulating osteoprotegerin ligand activity | 
| US7300774B1 (en) | 1999-12-09 | 2007-11-27 | The Regents Of The University Of California | Multimeric fusion proteins of the TNF superfamily ligands | 
| US20030022233A1 (en) | 1999-04-30 | 2003-01-30 | Raymond G. Goodwin | Methods of use of the taci/taci-l interaction | 
| US7662367B2 (en)* | 2000-03-02 | 2010-02-16 | Xencor, Inc. | Pharmaceutical compositions for the treatment of TNF-α related disorders | 
| IL136156A0 (en) | 2000-05-16 | 2001-05-20 | Compugen Ltd | Sequences of trail variants | 
| US6652854B2 (en)* | 2000-08-08 | 2003-11-25 | Immunex Corporation | Methods for treating autoimmune and chronic inflammatory conditions using antagonists of CD30 or CD30L | 
| AU8867501A (en) | 2000-09-01 | 2002-03-13 | Biogen Inc | Co-crystal structure of monoclonal antibody 5c8 and cd154, and use thereof in drug design | 
| AU2002232447A1 (en) | 2000-11-02 | 2002-05-15 | Immunex Corporation | Method of enhancing lymphocyte-mediated immune responses | 
| US20030013651A1 (en) | 2001-03-22 | 2003-01-16 | Barnes-Jewish Hospital | Stimulation of osteogenesis using rank ligand fusion proteins | 
| CA2452824A1 (en) | 2001-07-10 | 2003-01-23 | Xencor | Protein design automation for designing protein libraries with altered immunogenicity | 
| US20040186051A1 (en) | 2001-10-02 | 2004-09-23 | Kelley Robert F | Apo-2 ligand variants and uses thereof | 
| CN1635849A (en) | 2001-10-15 | 2005-07-06 | 巴恩斯-犹太医院 | Bone Antiresorptive Compounds | 
| IL161387A0 (en) | 2001-10-15 | 2004-09-27 | Barnes Jewish Hospital | Rankl mimics and uses thereof | 
| AU2003217174A1 (en) | 2002-01-04 | 2003-07-30 | Xencor | Novel variants of rankl protein | 
| WO2004089982A2 (en) | 2003-01-06 | 2004-10-21 | Xencor | April variants and methods thereof | 
| CA2523776A1 (en) | 2003-03-07 | 2004-09-23 | Xencor, Inc. | Baff mutants with at least one amino acid substitution and methods of their production | 
| US7642340B2 (en)* | 2003-03-31 | 2010-01-05 | Xencor, Inc. | PEGylated TNF-α variant proteins | 
| WO2005035570A2 (en) | 2003-10-10 | 2005-04-21 | Xencor, Inc. | Variants of cd40l protein | 
| Publication number | Priority date | Publication date | Assignee | Title | 
|---|---|---|---|---|
| WO2001025277A1 (en)* | 1999-10-07 | 2001-04-12 | Maxygen Aps | Single-chain antagonist polypeptides | 
| WO2001064889A2 (en)* | 2000-03-02 | 2001-09-07 | Xencor | Tnf-alpha variants for the treatment of tnf-alpha related disorders | 
| WO2003033720A2 (en)* | 2001-10-15 | 2003-04-24 | Xencor | Protein based tnf-alpha variants for the treatment of tnf-alpha related disorders | 
| Title | 
|---|
| DAHIYAT B I ET AL: "De novo protein design: fully automated sequence selection", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 278, no. 5335, 3 October 1997 (1997-10-03), pages 82 - 87, XP002188179, ISSN: 0036-8075* | 
| STEED P M ET AL: "Inactivation of TNF signaling by rationally designed dominant-negative TNF variants", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 301, no. 5641, 26 September 2003 (2003-09-26), pages 1895 - 1898, XP002320440, ISSN: 0036-8075* | 
| ZHANG X M ET AL: "SITE-DIRECTED MUTATIONAL ANALYSIS OF HUMAN TUMOR NECROSIS FACTOR-ALPHA RECEPTOR BINDING SITE AND STRUCTURE-FUNCTIONAL RELATIONSHIP", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,, US, vol. 267, no. 33, 25 November 1992 (1992-11-25), pages 24069 - 24075, XP002922635, ISSN: 0021-9258* | 
| Publication number | Publication date | 
|---|---|
| US20030166559A1 (en) | 2003-09-04 | 
| CA2472049A1 (en) | 2003-07-17 | 
| WO2003057856A2 (en) | 2003-07-17 | 
| US20030219864A1 (en) | 2003-11-27 | 
| JP2005530482A (en) | 2005-10-13 | 
| EP1576088A2 (en) | 2005-09-21 | 
| AU2003207464A1 (en) | 2003-07-24 | 
| US7399829B2 (en) | 2008-07-15 | 
| WO2003057856A3 (en) | 2005-12-22 | 
| Publication | Publication Date | Title | 
|---|---|---|
| EP1576088A4 (en) | Dominant negative proteins and methods thereof | |
| IL225633A0 (en) | Anti-alpha-v-beta - 6 antibodies and uses thereof | |
| EP1551447A4 (en) | Anti-addl antibodies and uses thereof | |
| GB0619264D0 (en) | Methods and lens | |
| EP1539941A4 (en) | Adzymes and uses thereof | |
| EP1575495A4 (en) | Compounds and methods | |
| IL166063A0 (en) | Antibodies and uses thereof | |
| AU2003272423A8 (en) | Centrosome proteins and uses thereof | |
| AU2003207628A8 (en) | Structural and cytoskeleton-associated proteins | |
| AU2003231827A8 (en) | Pseudo-tissues and uses thereof | |
| AU2003302173A8 (en) | Spirotetrathiocarbamates and spirooxothiocarbamates | |
| GB0203542D0 (en) | Classification and searching methods | |
| GB0224436D0 (en) | Polypetides methods and means | |
| AU2003280992A1 (en) | Novel proteins and use thereof | |
| GB0317376D0 (en) | Immunogenic protein and uses thereof | |
| AU2003292774A1 (en) | Novel proteins and use thereof | |
| EP1549951A4 (en) | Semaphorin-like proteins and methods of using same | |
| GB0223860D0 (en) | Polypeptide methods and means | |
| AU2003216442A8 (en) | Enkurin and uses thereof | |
| AU2003263751A8 (en) | Novel proteins and their uses | |
| EP1499338A4 (en) | 7-hydroxy-16alpha-fluoro-5-androsten-17-ones and 7-hydroxy-16alpha-fluoro-5-androstan-17-ones and derivatives thereof | |
| AU2003265814A8 (en) | Aw755252-interacting proteins and use thereof | |
| AU2003222227A8 (en) | Variant tat proteins and methods for use thereof | |
| AU2003249644A8 (en) | Mutant p53 (delta126-132) protein and uses thereof | |
| GB0206909D0 (en) | Suction apparatus and methods | 
| Date | Code | Title | Description | 
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase | Free format text:ORIGINAL CODE: 0009012 | |
| 17P | Request for examination filed | Effective date:20040727 | |
| AK | Designated contracting states | Kind code of ref document:A2 Designated state(s):AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT SE SI SK TR | |
| AX | Request for extension of the european patent | Extension state:AL LT LV MK RO | |
| RAP1 | Party data changed (applicant data changed or rights of an application transferred) | Owner name:XENCOR, INC. | |
| PUAK | Availability of information related to the publication of the international search report | Free format text:ORIGINAL CODE: 0009015 | |
| RIC1 | Information provided on ipc code assigned before grant | Ipc:C12P 21/06 20060101AFI20051228BHEP | |
| A4 | Supplementary search report drawn up and despatched | Effective date:20060809 | |
| STAA | Information on the status of an ep patent application or granted ep patent | Free format text:STATUS: THE APPLICATION HAS BEEN WITHDRAWN | |
| 18W | Application withdrawn | Effective date:20070212 |