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EP1576088A4 - Dominant negative proteins and methods thereof - Google Patents

Dominant negative proteins and methods thereof

Info

Publication number
EP1576088A4
EP1576088A4EP03705672AEP03705672AEP1576088A4EP 1576088 A4EP1576088 A4EP 1576088A4EP 03705672 AEP03705672 AEP 03705672AEP 03705672 AEP03705672 AEP 03705672AEP 1576088 A4EP1576088 A4EP 1576088A4
Authority
EP
European Patent Office
Prior art keywords
methods
dominant negative
negative proteins
proteins
dominant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03705672A
Other languages
German (de)
French (fr)
Other versions
EP1576088A2 (en
Inventor
John R Desjarlais
Malu Lourdes G Tansey
Bassil I Dahiyat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xencor Inc
Original Assignee
Xencor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xencor IncfiledCriticalXencor Inc
Publication of EP1576088A2publicationCriticalpatent/EP1576088A2/en
Publication of EP1576088A4publicationCriticalpatent/EP1576088A4/en
Withdrawnlegal-statusCriticalCurrent

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EP03705672A2002-01-042003-01-06Dominant negative proteins and methods thereofWithdrawnEP1576088A4 (en)

Applications Claiming Priority (5)

Application NumberPriority DateFiling DateTitle
US34580502P2002-01-042002-01-04
US345805P2002-01-04
US37345302P2002-04-172002-04-17
US373453P2002-04-17
PCT/US2003/000394WO2003057856A2 (en)2002-01-042003-01-06Dominant negative proteins and methods thereof

Publications (2)

Publication NumberPublication Date
EP1576088A2 EP1576088A2 (en)2005-09-21
EP1576088A4true EP1576088A4 (en)2006-09-06

Family

ID=26994550

Family Applications (1)

Application NumberTitlePriority DateFiling Date
EP03705672AWithdrawnEP1576088A4 (en)2002-01-042003-01-06Dominant negative proteins and methods thereof

Country Status (6)

CountryLink
US (2)US20030166559A1 (en)
EP (1)EP1576088A4 (en)
JP (1)JP2005530482A (en)
AU (1)AU2003207464A1 (en)
CA (1)CA2472049A1 (en)
WO (1)WO2003057856A2 (en)

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US9714282B2 (en)*2003-09-262017-07-25Xencor, Inc.Optimized Fc variants and methods for their generation
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WO2009120993A2 (en)*2008-03-282009-10-01The United States Of America, As Represented By The Secretary, Department Of Health & Human ServicesSynthetic analogs of the juxtamembrane domain of igf1r and uses thereof
NZ589086A (en)2008-04-112012-09-28Merrimack Pharmaceuticals IncHuman serum albumin (HSA) linkers and conjugates thereof
USRE48948E1 (en)2008-04-182022-03-01Warsaw Orthopedic, Inc.Clonidine compounds in a biodegradable polymer
WO2010059315A1 (en)2008-11-182010-05-27Merrimack Pharmaceuticals, Inc.Human serum albumin linkers and conjugates thereof
US20100239632A1 (en)2009-03-232010-09-23Warsaw Orthopedic, Inc.Drug depots for treatment of pain and inflammation in sinus and nasal cavities or cardiac tissue
EP2468764A1 (en)*2010-12-242012-06-27Rijksuniversiteit te GroningenTNF family ligand variants
US20150202287A1 (en)2012-08-302015-07-23Merrimack Pharmaceuticals, Inc.Combination therapies comprising anti-erbb3 agents
US9914761B2 (en)2014-07-102018-03-13Washington UniversityOligomers for TNF superfamily inhibition
KR101576904B1 (en)*2014-07-312015-12-14(주)케어젠Peptides Having Activities for Inhibiting Differentiation and Activity of Osteoclast and Uses Thereof
US11111284B2 (en)2014-08-212021-09-07The General Hospital CorporationTumor necrosis factor superfamily and TNF-like ligand muteins and methods of preparing

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WO2003033720A2 (en)*2001-10-152003-04-24XencorProtein based tnf-alpha variants for the treatment of tnf-alpha related disorders

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CA2452824A1 (en)2001-07-102003-01-23XencorProtein design automation for designing protein libraries with altered immunogenicity
US20040186051A1 (en)2001-10-022004-09-23Kelley Robert FApo-2 ligand variants and uses thereof
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Patent Citations (3)

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WO2001025277A1 (en)*1999-10-072001-04-12Maxygen ApsSingle-chain antagonist polypeptides
WO2001064889A2 (en)*2000-03-022001-09-07XencorTnf-alpha variants for the treatment of tnf-alpha related disorders
WO2003033720A2 (en)*2001-10-152003-04-24XencorProtein based tnf-alpha variants for the treatment of tnf-alpha related disorders

Non-Patent Citations (3)

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Title
DAHIYAT B I ET AL: "De novo protein design: fully automated sequence selection", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 278, no. 5335, 3 October 1997 (1997-10-03), pages 82 - 87, XP002188179, ISSN: 0036-8075*
STEED P M ET AL: "Inactivation of TNF signaling by rationally designed dominant-negative TNF variants", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 301, no. 5641, 26 September 2003 (2003-09-26), pages 1895 - 1898, XP002320440, ISSN: 0036-8075*
ZHANG X M ET AL: "SITE-DIRECTED MUTATIONAL ANALYSIS OF HUMAN TUMOR NECROSIS FACTOR-ALPHA RECEPTOR BINDING SITE AND STRUCTURE-FUNCTIONAL RELATIONSHIP", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,, US, vol. 267, no. 33, 25 November 1992 (1992-11-25), pages 24069 - 24075, XP002922635, ISSN: 0021-9258*

Also Published As

Publication numberPublication date
US20030166559A1 (en)2003-09-04
CA2472049A1 (en)2003-07-17
WO2003057856A2 (en)2003-07-17
US20030219864A1 (en)2003-11-27
JP2005530482A (en)2005-10-13
EP1576088A2 (en)2005-09-21
AU2003207464A1 (en)2003-07-24
US7399829B2 (en)2008-07-15
WO2003057856A3 (en)2005-12-22

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Legal Events

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Owner name:XENCOR, INC.

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