EP1007073A4 - PROCEDURES FOR EATING HABITS, COMPOUNDS SUITABLE FOR THESE PROCEDURES, AND DNA ENCODING A HYPOTHALAMIC ATYPICAL NEUROPEPTIDE Y / PEPTIDE YY RECEPTOR - Google Patents

PROCEDURES FOR EATING HABITS, COMPOUNDS SUITABLE FOR THESE PROCEDURES, AND DNA ENCODING A HYPOTHALAMIC ATYPICAL NEUROPEPTIDE Y / PEPTIDE YY RECEPTOR

Info

Publication number: EP1007073A4
Authority: EP; European Patent Office
Prior art keywords: procedures; hypothalamic; neuropeptide; atypical; peptide
Prior art date: 1996-06-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Other versions

Inventor

Christophe P G Gerald

Richard L Weinshank

Mary W Walker

Theresa Branchek

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Lundbeck Research USA Inc

Original Assignee

Synaptic Pharmaceutical Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-06-04

Filing date

1997-06-04

Publication date

2002-03-27

1996-06-04Priority claimed from US08/668,650external-prioritypatent/US5989920A/en

1997-06-04Application filed by Synaptic Pharmaceutical CorpfiledCriticalSynaptic Pharmaceutical Corp

2000-06-14Publication of EP1007073A1publicationCriticalpatent/EP1007073A1/en

2002-03-27Publication of EP1007073A4publicationCriticalpatent/EP1007073A4/en

StatusWithdrawnlegal-statusCriticalCurrent

Links

238000000034methodMethods0.000title2
108050002826Neuropeptide Y ReceptorProteins0.000title1
102100028427Pro-neuropeptide YHuman genes0.000title1
150000001875compoundsChemical class0.000title1
235000006694eating habitsNutrition0.000title1
230000002267hypothalamic effectEffects0.000title1
URPYMXQQVHTUDU-OFGSCBOVSA-Nnucleopeptide yChemical compoundC([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1URPYMXQQVHTUDU-OFGSCBOVSA-N0.000title1
108010070727peptide YY receptorProteins0.000title1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Cell Biology (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Biomedical Technology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Neurology (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

EP97928786A1996-06-041997-06-04 PROCEDURES FOR EATING HABITS, COMPOUNDS SUITABLE FOR THESE PROCEDURES, AND DNA ENCODING A HYPOTHALAMIC ATYPICAL NEUROPEPTIDE Y / PEPTIDE YY RECEPTORWithdrawnEP1007073A4 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US668650		1996-06-04
US08/668,650US5989920A (en)	1994-12-02	1996-06-04	Methods of modifying feeding behavior compounds useful in such methods and DNA encoding a hypothalmic atypical neuropeptide Y/peptide YY receptor Y5
US80360097A	1997-02-21	1997-02-21
US803600		1997-02-21
PCT/US1997/009504WO1997046250A1 (en)	1996-06-04	1997-06-04	Methods of modifying feeding behavior, compounds useful in such methods, and dna encoding a hypothalamic atypical neuropeptide y/peptide yy receptor (y5)

Publications (2)

Publication Number	Publication Date
EP1007073A1 EP1007073A1 (en)	2000-06-14
EP1007073A4true EP1007073A4 (en)	2002-03-27

Family

ID=27099966

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP97928786AWithdrawnEP1007073A4 (en)	1996-06-04	1997-06-04	PROCEDURES FOR EATING HABITS, COMPOUNDS SUITABLE FOR THESE PROCEDURES, AND DNA ENCODING A HYPOTHALAMIC ATYPICAL NEUROPEPTIDE Y / PEPTIDE YY RECEPTOR

Country Status (3)

Country	Link
EP (1)	EP1007073A4 (en)
AU (1)	AU3295297A (en)
WO (1)	WO1997046250A1 (en)

Families Citing this family (31)

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US5602024A (en)	1994-12-02	1997-02-11	Synaptic Pharmaceutical Corporation	DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) and uses thereof
US5989920A (en)	1994-12-02	1999-11-23	Synaptic Pharmaceutical Corporation	Methods of modifying feeding behavior compounds useful in such methods and DNA encoding a hypothalmic atypical neuropeptide Y/peptide YY receptor Y5
AUPN646795A0 (en)	1995-11-09	1995-11-30	Garvan Institute Of Medical Research	Neuropeptide Y-Y5 receptor
US6713265B1 (en)	1997-06-04	2004-03-30	Synaptic Pharmaceutical Corporation	Methods of modifying feeding behavior, compounds useful in such methods, and DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5)
SE9703414D0 (en)*	1997-09-23	1997-09-23	Astra Ab	New compounds
US6191160B1 (en)	1998-11-10	2001-02-20	Merck & Co., Inc.	Spiro-indolines as Y5 receptor antagonists
EP1184373A4 (en)	1999-04-20	2004-10-20	Meiji Seika Kaisha	Tricyclic compounds
CA2403307A1 (en)	2001-10-23	2003-04-23	Neurogen Corporation	Substituted 2-cyclohexyl-4-phenyl-1h-imidazole derivatives
NZ534757A (en)	2002-03-12	2006-07-28	Merck & Co Inc	Substituted amides
WO2004066966A2 (en)	2003-01-17	2004-08-12	Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S.	Peptide yy analogs
JP2004315511A (en)*	2003-03-31	2004-11-11	Taisho Pharmaceut Co Ltd	MCH receptor antagonist
ATE462432T1 (en)	2003-05-05	2010-04-15	Probiodrug Ag	GLUTAMINYL CYCLASE INHIBITORS
NZ546887A (en)	2003-11-03	2009-04-30	Probiodrug Ag	Combinations useful for the treatment of neuronal disorders
WO2005075436A2 (en)	2004-02-05	2005-08-18	Probiodrug Ag	Novel inhibitors of glutaminyl cyclase
US20060281712A1 (en)	2005-06-14	2006-12-14	Chi-Feng Yen	Pyrimidine compounds
US8193206B2 (en)	2005-06-14	2012-06-05	Taigen Biotechnology Co., Ltd.	Pyrimidine compounds
US8278345B2 (en)	2006-11-09	2012-10-02	Probiodrug Ag	Inhibitors of glutaminyl cyclase
DK2091948T3 (en)	2006-11-30	2012-07-23	Probiodrug Ag	Novel inhibitors of glutaminyl cyclase
AU2008220785B2 (en)	2007-03-01	2013-02-21	Vivoryon Therapeutics N.V.	New use of glutaminyl cyclase inhibitors
EP2865670B1 (en)	2007-04-18	2017-01-11	Probiodrug AG	Thiourea derivatives as glutaminyl cyclase inhibitors
NZ588989A (en)	2008-04-21	2012-03-30	Taigen Biotechnology Co Ltd	Heterocyclic compounds comprising pyrimidine, piperazine and amine.
US20090298834A1 (en)*	2008-06-02	2009-12-03	Hassan Pajouhesh	4-(aminomethyl)cyclohexanamine derivatives as calcium channel blockers
WO2010056847A2 (en)	2008-11-13	2010-05-20	Taigen Biotechnology Co., Ltd.	Lyophilization formulation
CA2772488C (en)	2009-09-11	2018-04-17	Probiodrug Ag	Heterocyclic derivatives as inhibitors of glutaminyl cyclase
ES2586231T3 (en)	2010-03-03	2016-10-13	Probiodrug Ag	Glutaminyl cyclase inhibitors
JP5688745B2 (en)	2010-03-10	2015-03-25	プロビオドルグエージー	Heterocyclic inhibitor of glutaminyl cyclase (QC, EC 2.3.2.5)
US8541596B2 (en)	2010-04-21	2013-09-24	Probiodrug Ag	Inhibitors
JP6050264B2 (en)	2011-03-16	2016-12-21	プロビオドルグエージー	Benzimidazole derivatives as inhibitors of glutaminyl cyclase
DK3461819T3 (en)	2017-09-29	2020-08-10	Probiodrug Ag	GLUTAMINYL CYCLASE INHIBITORS
WO2021007487A1 (en)	2019-07-11	2021-01-14	Praxis Precision Medicines, Inc.	Formulations of t-type calcium channel modulators and methods of use thereof
PL448201A1 (en)*	2024-04-05	2025-10-06	Politechnika Krakowska im. Tadeusza Kościuszki	New derivatives of N-{6-[(3,4-dihydroquinazolin-2-yl)amino]hexyl}naphthalene-sulfonamides, method of their preparation and their use

Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1996016542A1 (en)*	1994-12-02	1996-06-06	Synaptic Pharmaceutical Corporation	Methods of modifying feeding behavior, compounds useful in such methods, and dna encoding a hypothalamic atypical neuropeptide y/peptide yy receptor (y5)
WO1997017440A1 (en)*	1995-11-09	1997-05-15	Garvan Institute Of Medical Research	Neuropeptide y-y5 receptor
WO1997020820A1 (en)*	1995-12-01	1997-06-12	Novartis Ag	Heteroaryl compounds
WO1997020822A1 (en)*	1995-12-01	1997-06-12	Novartis Ag	Quinazolin-2,4-diazirines as npy receptor antagonist
WO1997037998A2 (en)*	1996-04-08	1997-10-16	Bayer Corporation	Neuropeptide y receptor y5 and nucleic acid sequence

1997
- 1997-06-04EPEP97928786Apatent/EP1007073A4/ennot_activeWithdrawn
- 1997-06-04AUAU32952/97Apatent/AU3295297A/ennot_activeAbandoned
- 1997-06-04WOPCT/US1997/009504patent/WO1997046250A1/ennot_activeApplication Discontinuation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1996016542A1 (en)*	1994-12-02	1996-06-06	Synaptic Pharmaceutical Corporation	Methods of modifying feeding behavior, compounds useful in such methods, and dna encoding a hypothalamic atypical neuropeptide y/peptide yy receptor (y5)
WO1997017440A1 (en)*	1995-11-09	1997-05-15	Garvan Institute Of Medical Research	Neuropeptide y-y5 receptor
WO1997020820A1 (en)*	1995-12-01	1997-06-12	Novartis Ag	Heteroaryl compounds
WO1997020822A1 (en)*	1995-12-01	1997-06-12	Novartis Ag	Quinazolin-2,4-diazirines as npy receptor antagonist
WO1997037998A2 (en)*	1996-04-08	1997-10-16	Bayer Corporation	Neuropeptide y receptor y5 and nucleic acid sequence

Non-Patent Citations (10)

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Title
BARD JONATHAN A ET AL: "Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 45, 1995, pages 26762 - 26765, XP002187958, ISSN: 0021-9258*
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1993, HERZOG HERBERT ET AL: "Molecular cloning, characterization, and localization of the human homolog to the reported bovine NPY Y3 receptor: Lack of NPY binding and activation.", XP002187960, Database accession no. PREV199396087299*
DNA AND CELL BIOLOGY, vol. 12, no. 6, 1993, pages 465 - 471, ISSN: 1044-5498*
GERALD C ET AL: "A RECEPTOR SUBTYPE INVOLVED IN NEUROPEPTIDE-Y-INDUCED FOOD INTAKE", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 382, 11 July 1996 (1996-07-11), pages 168 - 171, XP000612078, ISSN: 0028-0836*
GERALD CHRISTOPHE ET AL: "Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 45, 1995, pages 26758 - 26761, XP002187957, ISSN: 0021-9258*
HU Y ET AL: "IDENTIFICATION OF A NOVEL HYPOTHALAMIC NEUROPEPTIDE Y RECEPTOR ASSOCIATED WITH FEEDING BEHAVIOR", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 271, no. 42, 18 October 1996 (1996-10-18), pages 26315 - 26319, XP002040612, ISSN: 0021-9258*
LARHAMMAR D ET AL: "CLONING AND FUNCTIONAL EXPRESSION OF A HUMAN NEUROPEPTIDE Y-PEPTIDE YY RECEPTOR OF THE Y1 TYPE", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 267, no. 16, 1992, pages 10935 - 10938, XP000612077, ISSN: 0021-9258*
LUNDELL INGRID ET AL: "Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 49, 1995, pages 29123 - 29128, XP002187959, ISSN: 0021-9258*
ROSE PATRICIA M ET AL: "Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 39, 1995, pages 22661 - 22664, XP002187956, ISSN: 0021-9258*
See also references ofWO9746250A1*

Also Published As

Publication number	Publication date
WO1997046250A1 (en)	1997-12-11
EP1007073A1 (en)	2000-06-14
AU3295297A (en)	1998-01-05

Publication	Publication Date	Title
EP1007073A4 (en)	2002-03-27	PROCEDURES FOR EATING HABITS, COMPOUNDS SUITABLE FOR THESE PROCEDURES, AND DNA ENCODING A HYPOTHALAMIC ATYPICAL NEUROPEPTIDE Y / PEPTIDE YY RECEPTOR
DE59605800D1 (en)	2000-09-28	METHOD FOR HYDROGENATING AROMATIC COMPOUNDS IN WHICH AT LEAST ONE AMINO GROUP IS TIED TO AN AROMATIC CORE
ATE244304T1 (en)	2003-07-15	METHOD FOR ALTERING EATING BEHAVIOR, COMPOUNDS USABLE THEREFOR, AND DNA CODING A HYPOTHALAMIC ATYPICAL NEUROPEPTIDE Y/PEPTIDE YY RECEPTOR (Y5).
EP1107976A4 (en)	2005-01-05	ANTI-ENDOTOXIC, ANTIMICROBIAL CATIONIC PEPTIDES AND METHOD FOR THEIR USE
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ATE291423T1 (en)	2005-04-15	NON-PEPTIDIC GNRH AGENTIA, METHODS AND INTERMEDIATE COMPOUNDS FOR THE PRODUCTION THEREOF
DE59704009D1 (en)	2001-08-16	Locking device for a convertible top
IS5410A (en)	2000-03-20	New neuronal peptide Y antagonist (NPY)
DE19882508T1 (en)	2002-07-11	A memory-based VLSI architecture for image compression
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Legal Events

Date	Code	Title	Description
2000-04-28	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text:ORIGINAL CODE: 0009012
2000-06-14	17P	Request for examination filed	Effective date:19990104
2000-06-14	AK	Designated contracting states	Kind code of ref document:A1 Designated state(s):AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2002-03-27	A4	Supplementary search report drawn up and despatched	Effective date:20020213
2002-03-27	AK	Designated contracting states	Kind code of ref document:A4 Designated state(s):AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2003-11-05	17Q	First examination report despatched	Effective date:20030917
2006-01-20	STAA	Information on the status of an ep patent application or granted ep patent	Free format text:STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2006-03-08	18D	Application deemed to be withdrawn	Effective date:20050830

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