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EP0378666A4 - Interleukin ii analogs - Google Patents

Interleukin ii analogs

Info

Publication number
EP0378666A4
EP0378666A4EP19890908361EP89908361AEP0378666A4EP 0378666 A4EP0378666 A4EP 0378666A4EP 19890908361EP19890908361EP 19890908361EP 89908361 AEP89908361 AEP 89908361AEP 0378666 A4EP0378666 A4EP 0378666A4
Authority
EP
European Patent Office
Prior art keywords
interleukin
analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19890908361
Other versions
EP0378666A1 (en
Inventor
Bruce W. Altrock
Thomas C. Boone
Robert A. Goldman
William C. Kenny
Yitzhak Stabinsky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen IncfiledCriticalAmgen Inc
Publication of EP0378666A1publicationCriticalpatent/EP0378666A1/en
Publication of EP0378666A4publicationCriticalpatent/EP0378666A4/en
Withdrawnlegal-statusCriticalCurrent

Links

Classifications

Landscapes

EP198909083611988-07-051989-07-05Interleukin ii analogsWithdrawnEP0378666A4 (en)

Applications Claiming Priority (2)

Application NumberPriority DateFiling DateTitle
US2149981980-12-10
US21499888A1988-07-051988-07-05

Publications (2)

Publication NumberPublication Date
EP0378666A1 EP0378666A1 (en)1990-07-25
EP0378666A4true EP0378666A4 (en)1992-01-22

Family

ID=22801232

Family Applications (1)

Application NumberTitlePriority DateFiling Date
EP19890908361WithdrawnEP0378666A4 (en)1988-07-051989-07-05Interleukin ii analogs

Country Status (4)

CountryLink
EP (1)EP0378666A4 (en)
JP (1)JPH03500415A (en)
AU (1)AU627477B2 (en)
WO (1)WO1990000565A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US5312903A (en)*1990-06-011994-05-17E. I. Du Pont De Nemours And CompanyLysine-glycosylated recombinant interleukin-2
JPH05508634A (en)*1990-07-051993-12-02アクゾ・エヌ・ヴエー Receptor-specific toxin conjugate
US6358490B2 (en)1992-06-092002-03-19Neorx CorporationThree-step pretargeting methods and compounds
DE69331319T2 (en)*1992-06-092002-08-08Neorx Corp., Seattle Biotin-DOTA conjugates and their use in "pretargeting" processes
US5911969A (en)1992-06-091999-06-15Neorx CorporationPretargeting protocols for enhanced localization of active agents to target sites
US5696234A (en)*1994-08-011997-12-09Schering CorporationMuteins of mammalian cytokine interleukin-13
IL116436A (en)1995-12-182006-12-31Yissum Res Dev CoFc?Á-PE CHIMERIC PROTEIN FOR TARGETED TREATMENT OF ALLERGY RESPONSES AND
US6168785B1 (en)*1998-07-162001-01-02Institut PasteurBiological applications of new peptides of IL-2 and derivatives and use as therapeutic agents
US20060234205A1 (en)*2004-03-052006-10-19Chiron CorporationIn vitro test system for predicting patient tolerability of therapeutic agents
US20110274650A1 (en)2009-01-212011-11-10Amgen Inc.Compositions and methods of treating inflammatory and autoimmune diseases
PL3482766T3 (en)*2014-08-112020-11-16Delinia, Inc.Modified il-2 variants that selectively activate regulatory t cells for the treatment of autoimmune diseases
MY188430A (en)2015-04-102021-12-08Amgen IncInterleukin-2 muteins for the expansion of t-regulatory cells
US20170204154A1 (en)2016-01-202017-07-20Delinia, Inc.Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases
WO2018089420A1 (en)2016-11-082018-05-17Delinia, Inc.Il-2 variants for the treatment of autoimmune diseases
CN115427437B (en)2020-03-312024-04-19韩美药品株式会社Novel immunostimulatory IL-2 analogues

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US4568640A (en)*1981-05-111986-02-04Harvey RubinMethod of inserting amino acid analogs into proteins
EP0108146B1 (en)*1982-05-121987-01-28The President And Fellows Of Harvard CollegeFused genes encoding hybrid proteins, cloning vectors containing them and the use thereof
WO1985000817A1 (en)*1983-08-101985-02-28AmgenMicrobial expression of interleukin ii
US4636463A (en)*1984-04-051987-01-13Scripps Clinic And Research FoundationAntibodies to human interleukin-2 induced by synthetic polypeptides
US4761375A (en)*1984-05-081988-08-02Genetics Institute, Inc.Human interleukin-2 cDNA sequence
CA1340265C (en)*1985-01-181998-12-15Kirston E. KothsOxidation resistant muteins
US5391485A (en)*1985-08-061995-02-21Immunex CorporationDNAs encoding analog GM-CSF molecules displaying resistance to proteases which cleave at adjacent dibasic residues
JPS62185098A (en)*1986-02-101987-08-13Otsuka Pharmaceut Co LtdPolypeptide having interleukin ii activity

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BIOLOGY CHEMISTRY HOPPE-SEYLER, vol. 368, no. 9, 1987, page 1060; R. H\FER et al.: "Modification and introduction of protein glycosylation sites by site-specific mutagenesis: Studies on human interleukin 2"*
JOURNAL OF CELLULAR BIOCHEMISTRY-UCLA SYMPOSIA ON MOLECULAR & CELLULAR BIOLOGY, 15th ANNUAL MEETINGS, Suppl. 10A, 20th January-15th February 1986, page 77, abstract no. B32, Alan R. Liss, Inc., New York, US; G. JU et al.: "Site-directed mutagenesis of the human interleukin-2 gene product: Identification of amino acid residues required for biological activity"*
See also references ofWO9000565A1*

Also Published As

Publication numberPublication date
AU627477B2 (en)1992-08-27
EP0378666A1 (en)1990-07-25
AU3877689A (en)1990-02-05
JPH03500415A (en)1991-01-31
WO1990000565A1 (en)1990-01-25

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Legal Events

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