EP0368926A4 - Transfected cells containing plasmids having genes oriented in opposing directions and methods of obtaining the same - Google Patents

Transfected cells containing plasmids having genes oriented in opposing directions and methods of obtaining the same

Info

Publication number: EP0368926A4
Authority: EP; European Patent Office
Prior art keywords: obtaining; methods; same; transfected cells; cells containing
Prior art date: 1987-07-16
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Inventor

Linda M. Cashion

Kathi A. Begley

Wendy W. Colby

Michael John Morser

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Berlex Laboratories Inc

Original Assignee

Codon

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-07-16

Filing date

1988-07-15

Publication date

1991-11-27

1988-07-15Application filed by CodonfiledCriticalCodon

1990-05-23Publication of EP0368926A1publicationCriticalpatent/EP0368926A1/en

1991-11-27Publication of EP0368926A4publicationCriticalpatent/EP0368926A4/en

StatusWithdrawnlegal-statusCriticalCurrent

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)

Landscapes

Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

EP198809074661987-07-161988-07-15Transfected cells containing plasmids having genes oriented in opposing directions and methods of obtaining the sameWithdrawnEP0368926A4 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US7408387A	1987-07-16	1987-07-16
US74083		1993-06-08

Publications (2)

Publication Number	Publication Date
EP0368926A1 EP0368926A1 (en)	1990-05-23
EP0368926A4true EP0368926A4 (en)	1991-11-27

Family

ID=22117617

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP19880907466WithdrawnEP0368926A4 (en)	1987-07-16	1988-07-15	Transfected cells containing plasmids having genes oriented in opposing directions and methods of obtaining the same

Country Status (3)

Country	Link
EP (1)	EP0368926A4 (en)
AU (1)	AU2263288A (en)
WO (1)	WO1989000605A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3744595A1 (en)*	1987-12-31	1989-07-13	Andreas Dr Plueckthun	METHOD FOR THE GENETIC ENGINEERING OF ANTIBODY
DE4410188A1 (en)*	1994-03-24	1995-09-28	Boehringer Mannheim Gmbh	Gene therapy method using antibiotic resistance gene-free DNA vectors
GB9603803D0 (en)*	1996-02-22	1996-04-24	Zeneca Ltd	Production of proteins, plasmids coding therefor and organisms containing such plasmids
EP1308517A1 (en)*	2001-10-31	2003-05-07	Aventis Pharmacueticals Products Inc.	Vectors for expressing multiple transgenes
DK2592148T3 (en)	2007-10-12	2018-12-10	Hoffmann La Roche	Protein expression from multiple nucleic acids
NZ756132A (en)	2017-03-10	2022-02-25	Hoffmann La Roche	Method for producing multispecific antibodies

Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0048202A2 (en)*	1980-09-11	1982-03-24	Merck & Co. Inc.	Method of preparing a mycoplasma-free hepatoma cell line
EP0113319A2 (en)*	1982-12-30	1984-07-11	Elaine Lynette Dr. Wilson	Cell lines and their use for the production of proteins
EP0211260A1 (en)*	1985-07-10	1987-02-25	Kanegafuchi Kagaku Kogyo Kabushiki Kaisha	Chromosomal DNA sequence, expression vector for human tissue plasminogen activating factor, cultured cells transfected with same and method of producing said activating factor
US4663281A (en)*	1984-03-22	1987-05-05	Mass Institute Of Technology	Enhanced production of proteinaceous materials in eucaryotic cells

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0192658A4 (en)*	1984-07-30	1987-07-13	Salk Inst For Biological Studi	Retroviral gene transfer vectors.
CA1319120C (en)*	1985-04-01	1993-06-15	John Henry Kenten	Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same

1988
- 1988-07-15AUAU22632/88Apatent/AU2263288A/ennot_activeAbandoned
- 1988-07-15EPEP19880907466patent/EP0368926A4/ennot_activeWithdrawn
- 1988-07-15WOPCT/US1988/002411patent/WO1989000605A1/ennot_activeApplication Discontinuation

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0048202A2 (en)*	1980-09-11	1982-03-24	Merck & Co. Inc.	Method of preparing a mycoplasma-free hepatoma cell line
EP0113319A2 (en)*	1982-12-30	1984-07-11	Elaine Lynette Dr. Wilson	Cell lines and their use for the production of proteins
US4663281A (en)*	1984-03-22	1987-05-05	Mass Institute Of Technology	Enhanced production of proteinaceous materials in eucaryotic cells
EP0211260A1 (en)*	1985-07-10	1987-02-25	Kanegafuchi Kagaku Kogyo Kabushiki Kaisha	Chromosomal DNA sequence, expression vector for human tissue plasminogen activating factor, cultured cells transfected with same and method of producing said activating factor

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
GENE, vol. 49, no. 1, 1986, pages 1-8, Elsevier, Amsterdam, NL; M. DREANO et al.: "High level, heatregulated synthesis of proteins in eukaryotic cells"*
GENE, vol. 64, no. 1, 15h April 1988, pages 43-51, Elsevier, Amsterdam, NL; M.B. HENDRICKS et al.: "A high-efficiency vector for expression of foreign genes in myeloma cells"*
J. NATL. CANCER INST., vol. 59, no. 1, July 1977, pages 221-226; J. FOGH et al.: "One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice"*
MOLECULAR AND CELLULAR BIOLOGY, vol. 5, no. 12, December 1985, pages 3403-3409, American Society for Microbiology; S. CHAKRABARTI et al.: "Vaccinia virus expression vector: coexpression of beta-galactosidase provides visual screening of recombinant virus plaques"*
See also references ofWO8900605A1*

Also Published As

Publication number	Publication date
WO1989000605A1 (en)	1989-01-26
EP0368926A1 (en)	1990-05-23
AU2263288A (en)	1989-02-13

Publication	Publication Date	Title
HUT43874A (en)	1987-12-28	Genes degredating halogenarylnitriles and cells comprising the genes
GB8701900D0 (en)	1987-03-04	Expression of genes in plants
JPS6447796A (en)	1989-02-22	Alkylglucoside and manufacture
EP0073460A3 (en)	1984-01-04	Laminar batteries and methods of making the same
AU1778888A (en)	1988-12-22	Improvements in and relating to the storage of liquids
ZA884529B (en)	1989-03-29	Curable mixtures and their use
HUT40712A (en)	1987-01-28	Method of preparing electrode and application of the electrode in electrochemical process
EP0204659A3 (en)	1988-06-08	Polyepoxydes and their use
GB2184401B (en)	1989-10-11	Improvements in buoyancy and stability apparatus
HUT45558A (en)	1988-07-28	Increased expressing human-interleukin 2 in mammalian celles
DE3480006D1 (en)	1989-11-09	Improvements in the expression of newly introduced genes in yeast cells
GB2154248B (en)	1988-02-03	Improvements in the manufacture of electrodes
EP0368926A4 (en)	1991-11-27	Transfected cells containing plasmids having genes oriented in opposing directions and methods of obtaining the same
EP0248656A3 (en)	1989-05-24	Composition for cell cultivation and use thereof
JPS6470548A (en)	1989-03-16	Compatible polymer mixture and formed body
GB2161476B (en)	1988-01-27	2-aminothiazolyl-2-methoxyimino acetamides and their use in preparing cephalosporins
DE3562486D1 (en)	1988-06-09	Arginyl-3-carboxy-4-hydroxyanilide and their use
GB8428181D0 (en)	1984-12-12	Posting material in and out of enclosures
AU5863686A (en)	1986-11-18	Improvements in and relating to foam treatment of textile materials
GB2175698B (en)	1989-07-05	Fluid-gauging probes and their manufacture
GB2157684B (en)	1987-11-11	Triazolopyrimidines their preparation and use in medicine
DE3666044D1 (en)	1989-11-09	Bisindoline pigments and their use
GB2169832B (en)	1988-05-25	Improvements in or relating to the plug drawing of tubes and other hollow items
SG77787G (en)	1989-11-17	Apparatus for use in the preparation and/or storage of food-stuffs
GB2179080B (en)	1988-06-29	Suspension of powders in liquid for soil injection and the like

Legal Events

Date	Code	Title	Description
1990-04-07	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text:ORIGINAL CODE: 0009012
1990-05-23	17P	Request for examination filed	Effective date:19900111
1990-05-23	AK	Designated contracting states	Kind code of ref document:A1 Designated state(s):AT BE CH DE FR GB IT LI LU NL SE
1991-09-04	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name:BERLEX LABORATORIES, INC.
1991-11-27	A4	Supplementary search report drawn up and despatched	Effective date:19911011
1991-11-27	AK	Designated contracting states	Kind code of ref document:A4 Designated state(s):AT BE CH DE FR GB IT LI LU NL SE
1992-07-22	17Q	First examination report despatched	Effective date:19920605
1994-02-02	STAA	Information on the status of an ep patent application or granted ep patent	Free format text:STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
1994-03-23	18D	Application deemed to be withdrawn	Effective date:19930923

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