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ECSP055621A - Aza-biciclo-alquil-éteres y su uso como agonistas de alfa7-nachr - Google Patents

Aza-biciclo-alquil-éteres y su uso como agonistas de alfa7-nachr

Info

Publication number
ECSP055621A
ECSP055621AECSP055621AECSP055621AEC SP055621 AECSP055621 AEC SP055621AEC SP055621 AECSP055621 AEC SP055621AEC SP055621 AECSP055621 AEC SP055621A
Authority
EC
Ecuador
Prior art keywords
aza
éteres
alfa7
biciclo
alquil
Prior art date
Application number
Other languages
English (en)
Inventor
Dominik Feuerbach
Konstanze Hurth
Timothy John Ritchie
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filedlitigationCriticalhttps://patents.darts-ip.com/?family=9943515&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP055621(A)"Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis AgfiledCriticalNovartis Ag
Publication of ECSP055621ApublicationCriticalpatent/ECSP055621A/es

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Abstract

La presente invención se refiere a derivados de 1-aza-bicicloalquilo de la fórmula (I): en donde X es CH2 o un enlace individual; Y es un grupo de la fórmula (II, III, IV); y en donde R tiene los significados definidos en la memoria descriptiva, cuyos compuestos son agonistas del receptor de acetilcolina nicotínico alfa-7 (nAChR);a procesos para su producción, a su uso como productos farmacéuticos, y a composiciones farmacéuticas que los comprenden
ECSP0556212002-09-042005-02-22Aza-biciclo-alquil-éteres y su uso como agonistas de alfa7-nachrECSP055621A (es)

Applications Claiming Priority (1)

Application NumberPriority DateFiling DateTitle
GB0220581AGB0220581D0 (en)2002-09-042002-09-04Organic Compound

Publications (1)

Publication NumberPublication Date
ECSP055621Atrue ECSP055621A (es)2005-04-18

Family

ID=9943515

Family Applications (1)

Application NumberTitlePriority DateFiling Date
ECSP055621ECSP055621A (es)2002-09-042005-02-22Aza-biciclo-alquil-éteres y su uso como agonistas de alfa7-nachr

Country Status (25)

CountryLink
US (8)US20060167002A1 (es)
EP (3)EP1537104B1 (es)
JP (2)JP4348422B2 (es)
KR (2)KR100808324B1 (es)
CN (1)CN1325493C (es)
AT (1)ATE448225T1 (es)
AU (1)AU2003260486C1 (es)
BR (2)BRPI0314325B8 (es)
CA (1)CA2495685C (es)
CY (1)CY1109765T1 (es)
DE (1)DE60330015D1 (es)
DK (1)DK1537104T3 (es)
EC (1)ECSP055621A (es)
ES (1)ES2336099T3 (es)
GB (1)GB0220581D0 (es)
IL (2)IL166918A (es)
MX (1)MXPA05002546A (es)
NO (1)NO331556B1 (es)
NZ (1)NZ538534A (es)
PL (1)PL209425B1 (es)
PT (1)PT1537104E (es)
RU (1)RU2352569C2 (es)
SI (1)SI1537104T1 (es)
WO (1)WO2004022556A1 (es)
ZA (1)ZA200500816B (es)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
JPS6262265A (ja)*1985-09-131987-03-18Hitachi Ltd復水器自動検査補修システム
DE10164139A1 (de)2001-12-272003-07-10Bayer Ag2-Heteroarylcarbonsäureamide
GB0220581D0 (en)2002-09-042002-10-09Novartis AgOrganic Compound
US7750022B2 (en)2003-08-132010-07-06Neurosearch A/SQuinuclidine derivatives and their pharmaceutical use
US20050137217A1 (en)*2003-12-222005-06-23Jianguo JiSpirocyclic quinuclidinic ether derivatives
US20050137203A1 (en)*2003-12-222005-06-23Jianguo Ji3-quinuclidinyl amino-substituted biaryl derivatives
US7160876B2 (en)*2003-12-222007-01-09Abbott LaboratoriesFused bicycloheterocycle substituted quinuclidine derivatives
US7241773B2 (en)2003-12-222007-07-10Abbott Laboratories3-quinuclidinyl heteroatom bridged biaryl derivatives
US20050137398A1 (en)*2003-12-222005-06-23Jianguo Ji3-Quinuclidinyl heteroatom bridged biaryl derivatives
US20050245531A1 (en)*2003-12-222005-11-03Abbott LaboratoriesFused bicycloheterocycle substituted quinuclidine derivatives
US7655657B2 (en)2003-12-222010-02-02Abbott LaboratoriesFused bicycloheterocycle substituted quinuclidine derivatives
US7309699B2 (en)2003-12-222007-12-18Abbott Laboratories3-Quinuclidinyl amino-substituted biaryl derivatives
CA2551486A1 (en)*2003-12-222006-06-22Abbott LaboratoriesFused bicycloheterocycle substituted quinuclidine derivatives
PE20060437A1 (es)2004-06-182006-06-08Novartis AgCOMPUESTOS AZA-BICICLONONANOS COMO LIGANDOS COLINERGICOS DE nAChR
GB0415746D0 (en)*2004-07-142004-08-18Novartis AgOrganic compounds
WO2006101521A2 (en)2004-09-202006-09-28Xenon Pharmaceuticals Inc.Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
CA2580845A1 (en)*2004-09-202006-03-30Xenon Pharmaceuticals Inc.Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase
JP2008513515A (ja)2004-09-202008-05-01ゼノン・ファーマシューティカルズ・インコーポレイテッド複素環誘導体および治療薬としてのそれらの使用
GB0424564D0 (en)2004-11-052004-12-08Novartis AgOrganic compounds
AU2006343359A1 (en)2005-06-032007-11-15Xenon Pharmaceuticals Inc.Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
GB0521508D0 (en)*2005-10-212005-11-30Novartis AgOrganic compounds
GB0525673D0 (en)2005-12-162006-01-25Novartis AgOrganic compounds
GB0525672D0 (en)*2005-12-162006-01-25Novartis AgOrganic compounds
JP2009526777A (ja)2006-02-142009-07-23ノイロサーチ アクティーゼルスカブニコチン性アセチルコリン受容体作用薬としての3,9−ジアザビシクロ(3.3.1)ノナ−3−イル−アリールメタノン誘導体
JP2009526814A (ja)*2006-02-162009-07-23ノイロサーチ アクティーゼルスカブ鏡像異性的に純粋なキヌクリジニルオキシピリダジン、及びニコチン性アセチルコリン受容体リガンドとしてのその使用
KR101475088B1 (ko)2006-08-212014-12-23제넨테크, 인크.아자-벤조티오페닐 화합물 및 사용 방법
RU2476220C2 (ru)*2007-08-022013-02-27Таргасепт, Инк.(2s,3r)-n-(2-((3-пиридинил)метил)-1-азабицикло[2.2.2]окт-3-ил)бензофуран-2-карбоксамид, новые солевые формы и способы их применения
US8383657B2 (en)2007-12-212013-02-26Abbott LaboratoriesThiazolylidine urea and amide derivatives and methods of use thereof
PE20110570A1 (es)2008-07-012011-08-26Genentech IncHeterociclos biciclicos sustituidos
EP2307364B1 (en)2008-07-012013-06-19Genentech, Inc.Isoindolone derivatives as mek kinase inhibitors and methods of use
DK2355822T3 (da)*2008-11-192013-01-28Envivo Pharmaceuticals Incbehandling af kognitive forstyrrelser med (R)-7-chlor-N-(quinuclidin-3-yl)benzoe[b]thiophen-2-carboxamid og farmaceutisk acceptable salte deraf
JP5808319B2 (ja)*2009-05-112015-11-10フォルム ファーマシューティカルズ、インコーポレイテッドアセチルコリンエステラーゼ阻害剤と組み合わせた特定のα7ニコチン酸受容体を用いた認知障害の治療
WO2011009890A2 (en)2009-07-232011-01-27Novartis AgUse of azabicycloalkyl derivatives or pyrrolidine-2-one derivatives
TWI558398B (zh)2009-09-222016-11-21諾華公司菸鹼乙醯膽鹼受體α7活化劑之用途
AU2010305825A1 (en)2009-10-132012-04-19Merck Sharp & Dohme B.V.Condensed azine - derivatives for the treatment of diseases related to the acetylcholine receptor
PE20170923A1 (es)2010-05-172017-07-12Forum Pharmaceuticals IncUna forma cristalina de clorhidrato de (r)-7-cloro-n-(quinuclidin-3-il)benzo[b]tiofeno-2-carboxamida monohidratado
EP2667862A1 (en)*2011-01-272013-12-04Novartis AGUse of nicotinic acetylcholine receptor alpha 7 activators
MX2013010698A (es)2011-03-182014-02-17Novartis AgCombinaciones de activadores del receptor de acetil-colina nicotinico alfa-7 y antagonistas del receptor de glutamato metabotropico 5 (mglur5) para usarse en la discinesia inducida por dopamina en la enfermedad de parkinson.
WO2013010679A1 (en)*2011-07-152013-01-24Novartis AgSalts of aza-bicyclic di-aryl ethers and methods to make them or their precursors
EP2768507B1 (en)*2011-10-202019-12-11Novartis AGBiomarkers predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment
MX358512B (es)2012-05-082018-08-24Forum Pharmaceuticals IncUso de (r)-7cloro-n-(quinuclidin-3-il) benzo[b] tiofeno-2-carboxamida o una sal farmacéuticamente aceptable de la misma para preparar una composición farmacéutica en el tratamiento de una disfunción cognitiva.
AU2013356914B2 (en)*2012-12-112017-01-05Novartis AgBiomarker predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment
EP3251673A1 (en)*2012-12-132017-12-06IP Gesellschaft für Management mbHCombination therapy comprising a cdk4/6 inhibitor and a pi3k inhibitor for use in the treatment of cancer
EP2945633B1 (en)2013-01-152021-06-30Novartis AGUse of alpha 7 nicotinic acetylcholine receptor agonists
ES2865736T3 (es)*2013-01-152021-10-15Novartis AgUso de agonistas del receptor de acetilcolina nicotínico alfa 7
WO2014111751A1 (en)2013-01-152014-07-24Novartis AgUse of alpha 7 nicotinic receptor agonists for the treatment of narcolepsy
US20150313884A1 (en)*2013-01-152015-11-05Novartis AgUse of alpha 7 nicotinic acetylcholine receptor agonists
GB201301626D0 (en)2013-01-302013-03-13Dignity Sciences LtdComposition comprising 15-OHEPA and methods of using the same
AR119731A1 (es)2019-05-172022-01-05Novartis AgInhibidores del inflamasoma nlrp3
US20210315851A1 (en)2020-04-032021-10-14Afimmune LimitedCompositions comprising 15-hepe and methods of treating or preventing hematologic disorders, and/or related diseases
AU2021387993A1 (en)2020-11-252023-06-08Vanda Pharmaceuticals Inc.Treatment of public speaking anxiety with an alpha-7 nicotinic acetylcholine receptor agonist
KR20250005196A (ko)*2022-05-052025-01-09필립모리스 프로덕츠 에스.에이.니코틴 아세틸콜린 수용체 리간드
US20240067627A1 (en)2022-08-032024-02-29Novartis AgNlrp3 inflammasome inhibitors

Family Cites Families (95)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
GB809574A (en)1956-01-261959-02-25Gasaccumulator Svenska AbImprovements in or relating to electrical signal light systems
US3539573A (en)1967-03-221970-11-10Jean Schmutz11-basic substituted dibenzodiazepines and dibenzothiazepines
BE759371A (fr)1969-11-241971-05-24Bristol Myers CoAzaspirodecanediones heterocycliques et procedes pour leur preparation
DE2139107A1 (de)1971-08-041973-02-15Merck Patent GmbhHeterocyclisch substituierte adenosinverbindungen
ZA848275B (en)1983-12-281985-08-28DegussaNew piridine-2-ethers or pyridine-2-thioethers having a nitrogen-containing cycloaliphatic ring
US4605652A (en)1985-02-041986-08-12A. H. Robins Company, Inc.Method of enhancing memory or correcting memory deficiency with arylamido (and arylthioamido)-azabicycloalkanes
DE3687980T2 (de)1986-01-071993-06-17Beecham Group PlcIndolderivate mit einer azabicyclischen seitenkette, verfahren zu ihrer herstellung, zwischenprodukte und pharmazeutische zusammensetzungen.
KR880007433A (ko)1986-12-221988-08-27메리 앤 터커3-아릴옥시-3-치환된 프로판아민
EP0287356B1 (en)1987-04-151996-01-24Beecham Group PlcBridgehead substituted azabicyclic derivatives
CA1307790C (en)1987-08-041992-09-22Ian Anthony CliffeEthers
GB8718445D0 (en)1987-08-041987-09-09Wyeth John & Brother LtdPyridyl-ethers
US5006528A (en)1988-10-311991-04-09Otsuka Pharmaceutical Co., Ltd.Carbostyril derivatives
DE8817121U1 (de)1988-11-221993-02-04Boehringer Ingelheim Kg, 55218 IngelheimNeue Quinuclidine
GB8829079D0 (en)1988-12-131989-01-25Beecham Group PlcNovel compounds
CA2002182C (en)1989-11-032000-06-13Richard J. WurtmanCompositions for treating the premenstrual or late luteal phase syndrome and methods for their use
DE4116582A1 (de)1990-05-191991-11-21Boehringer Ingelheim KgBicyclische 1-aza-cycloalkane
YU84791A (sh)1990-05-191994-06-10Boehringer Ingelheim Kg.Biciklicni 1-aza-cikloalkalni
AU8405991A (en)*1990-08-311992-03-30Nippon Shinyaku Co. Ltd.Pyrimidine derivative and medicine
JP3087763B2 (ja)1990-11-302000-09-11三井化学株式会社新規な複素環式化合物およびそれを含有する医薬組成物
US5260303A (en)*1991-03-071993-11-09G. D. Searle & Co.Imidazopyridines as serotonergic 5-HT3 antagonists
US5385912A (en)1991-03-081995-01-31Rhone-Poulenc Rorer Pharmaceuticals Inc.Multicyclic tertiary amine polyaromatic squalene synthase inhibitors
WO1992015579A1 (en)1991-03-081992-09-17Rhone-Poulenc Rorer International (Holdings) Inc.Multicyclic tertiary amine polyaromatic squalene synthetase inhibitors
WO1992021677A1 (en)*1991-05-311992-12-10Pfizer Inc.bibNUCLIDINE DERIVATIVES
JPH05310732A (ja)1992-03-121993-11-22Mitsubishi Kasei Corpシンノリン−3−カルボン酸誘導体
EP0596058A1 (en)1992-04-101994-05-11Zeneca LimitedBiphenylylquinuclidine derivatives as squalene synthase inhibitors
IL107184A (en)1992-10-091997-08-14Abbott LabHeterocyclic ether compounds that enhance cognitive function
WO1995031458A1 (en)1992-10-131995-11-23Rhone-Poulenc Rorer Pharmaceuticals Inc.3-hydroxyquinuclidin-3-ylphenylquinolines as squalene synthase inhibitors
JPH06293768A (ja)1993-02-121994-10-21Sankyo Co Ltdイソオキサゾールオキシ誘導体
AU6010594A (en)1993-02-121994-08-29Sankyo Company LimitedIsoxazoleoxy derivative
JP3235913B2 (ja)1993-07-302001-12-04エーザイ株式会社アミノ安息香酸誘導体
US5998404A (en)1994-10-241999-12-07Eli Lilly And CompanyHeterocyclic compounds and their use
EP0853621A1 (en)1995-09-221998-07-22Novo Nordisk A/SNovel substituted azacyclic or azabicyclic compounds
SE9600683D0 (sv)1996-02-231996-02-23Astra AbAzabicyclic esters of carbamic acids useful in therapy
AU744368B2 (en)1997-05-302002-02-21Neurosearch A/SSpiro-quinuclidine derivatives, their preparation and use
AR013184A1 (es)1997-07-182000-12-13Astrazeneca AbAminas heterociclicas espiroazobiciclicas, composicion farmaceutica, uso de dichas aminas para preparar medicamentos y metodo de tratamiento o profilaxis
US6953855B2 (en)1998-12-112005-10-11Targacept, Inc.3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof
US6432975B1 (en)1998-12-112002-08-13Targacept, Inc.Pharmaceutical compositions and methods for use
SE9900100D0 (sv)1999-01-151999-01-15Astra AbNew compounds
ATE408406T1 (de)1999-07-282008-10-15Univ Leland Stanford JuniorVerwendung von nikotin in der angiogenese und der vaskulogenese
SE9903760D0 (sv)1999-10-181999-10-18Astra AbNew compounds
SE9904176D0 (sv)1999-11-181999-11-18Astra AbNew use
SE0000540D0 (sv)*2000-02-182000-02-18Astrazeneca AbNew compounds
AU2001241056A1 (en)2000-03-092001-09-17Mitsubishi Pharma CorporationSpiro compounds, process for preparing the same and use thereof as drugs
GB0010955D0 (en)2000-05-052000-06-28Novartis AgOrganic compounds
JP4616971B2 (ja)2000-07-182011-01-19田辺三菱製薬株式会社1−アザビシクロアルカン化合物およびその医薬用途
WO2002016358A2 (en)2000-08-182002-02-28Pharmacia & Upjohn CompanyQuinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands)
WO2002015662A2 (en)2000-08-212002-02-28Pharmacia & Upjohn CompanyQuinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists
GB0021885D0 (en)2000-09-062000-10-18Fujisawa Pharmaceutical CoNew use
PE20021019A1 (es)2001-04-192002-11-13Upjohn CoGrupos azabiciclicos sustituidos
AR036040A1 (es)2001-06-122004-08-04Upjohn CoCompuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen
CA2464194A1 (en)2001-10-262003-05-08Pharmacia & Upjohn CompanyN-azabicyclo-substituted hetero-bicyclic carboxamides as nachr agonists
DE10156719A1 (de)2001-11-192003-05-28Bayer AgHeteroarylcarbonsäureamide
DE10162375A1 (de)2001-12-192003-07-10Bayer AgBicyclische N-Aryl-amide
AU2003214936A1 (en)2002-02-202003-09-09Pharmacia And Upjohn CompanyAzabicyclic compounds with alfa7 nicotinic acetylcholine receptor activity
DE10211415A1 (de)*2002-03-152003-09-25Bayer AgBicyclische N-Biarylamide
DE10211416A1 (de)*2002-03-152003-09-25Bayer AgEssig- und Propionsäureamide
DE10234424A1 (de)2002-07-292004-02-12Bayer AgBenzothiophen-, Benzofuran- und Indolharnstoffe
BR0313153A (pt)*2002-08-142005-06-28Neurosearch AsDerivado de quinuclidina, composição farmacêutica, uso de um derivado de quinuclidina, e, método de tratamento, prevenção ou alìvio de uma doença ou um distúrbio ou uma condição de um corpo animal vivo
GB0220581D0 (en)2002-09-042002-10-09Novartis AgOrganic Compound
AU2003276919B2 (en)2002-09-252013-05-16Memory Pharmaceuticals CorporationIndazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof
AU2003284898A1 (en)2002-10-292004-05-25Micro, Inc.Combinative nicotinic/d1 agonism therapy for the treatment of alzheimer's disease
WO2004039366A1 (en)2002-11-012004-05-13Pharmacia & Upjohn Company LlcNicotinic acetylcholine agonists in the treatment of glaucoma and retinal neuropathy
AU2003269401A1 (en)2002-11-012004-05-25Pharmacia & Upjohn Company LlcCompounds having both alpha7 nachr agonist and 5ht antagonist activity for treatment of cns diseases
WO2004043960A1 (en)2002-11-112004-05-27Neurosearch A/S1,4-diazabicyclo (3,2,2)nonane derivatives, preparation and therapeutical use thereof
BR0317110A (pt)*2002-12-112005-10-25Pharmacia & Upjohn Co LlcTratamento de doenças com combinações de agonistas do receptor nicotìnico da acetilcolina alfa 7 e outros compostos
KR20050092777A (ko)2003-01-222005-09-22파마시아 앤드 업존 캄파니 엘엘씨알파-7 nACh 수용체 전체 작용물질을 사용하는 질병의치료
WO2005013910A2 (en)*2003-08-072005-02-17University Of South FloridaCholinergic modulation of microglial activation via alpha-7 nicotinic receptors
JP4226981B2 (ja)2003-09-242009-02-18三井金属鉱業株式会社プリント配線板の製造方法及びその製造方法で得られたプリント配線板
US7655657B2 (en)*2003-12-222010-02-02Abbott LaboratoriesFused bicycloheterocycle substituted quinuclidine derivatives
US7241773B2 (en)*2003-12-222007-07-10Abbott Laboratories3-quinuclidinyl heteroatom bridged biaryl derivatives
US20050137203A1 (en)2003-12-222005-06-23Jianguo Ji3-quinuclidinyl amino-substituted biaryl derivatives
US20050137398A1 (en)2003-12-222005-06-23Jianguo Ji3-Quinuclidinyl heteroatom bridged biaryl derivatives
US20070060588A1 (en)*2003-12-222007-03-15Jianguo JiFused bicycloheterocycle substituted quinuclidine derivatives
US7160876B2 (en)*2003-12-222007-01-09Abbott LaboratoriesFused bicycloheterocycle substituted quinuclidine derivatives
US20050245531A1 (en)*2003-12-222005-11-03Abbott LaboratoriesFused bicycloheterocycle substituted quinuclidine derivatives
US20050137204A1 (en)*2003-12-222005-06-23Abbott LaboratoriesFused bicycloheterocycle substituted quinuclidine derivatives
CA2551486A1 (en)2003-12-222006-06-22Abbott LaboratoriesFused bicycloheterocycle substituted quinuclidine derivatives
MXPA06007213A (es)*2003-12-232006-08-18Pfizer Prod IncCombinacion terapeutica para la mejora de la cognicion y trastornos sicoticos.
EP1718306A2 (en)2004-02-202006-11-08Chiron CorporationModulation of inflammatory and metastatic processes
AU2005233642A1 (en)*2004-04-132005-10-27Astellas Pharma Inc.Polycyclic pyridines as potassium ion channel modulators
JP2007538046A (ja)2004-05-192007-12-27ノイロサーチ アクティーゼルスカブ新規なアザビシクロアリール誘導体
PE20060437A1 (es)2004-06-182006-06-08Novartis AgCOMPUESTOS AZA-BICICLONONANOS COMO LIGANDOS COLINERGICOS DE nAChR
GB0415746D0 (en)2004-07-142004-08-18Novartis AgOrganic compounds
AU2005293510A1 (en)2004-10-152006-04-20Neurosearch A/SNovel azabicyclic aryl derivatives and their medical use
GB0424564D0 (en)2004-11-052004-12-08Novartis AgOrganic compounds
ATE481407T1 (de)*2005-02-162010-10-15Neurosearch AsNeue diazabicyclische arylderivate und medizinische verwendung dafür
JP2008533142A (ja)*2005-03-182008-08-21アボット・ラボラトリーズα7ニューロンニコチン性受容体リガンドおよび抗精神病薬組成物
WO2006113650A1 (en)*2005-04-182006-10-26Khan Saeed RDesign and synthesis of novel tubulin polymerization inhibitors: bonzoylphenyluria (bpu) sulfur analogs
FR2884822B1 (fr)*2005-04-222007-06-29Aventis Pharma SaDerives de triazines, leur preparation et leur application en therapeutique
GB0508314D0 (en)*2005-04-252005-06-01Novartis AgOrganic compounds
KR20080029965A (ko)*2005-06-142008-04-03쉐링 코포레이션아스파르틸 프로테아제 억제제
GB0521508D0 (en)*2005-10-212005-11-30Novartis AgOrganic compounds
GB0525672D0 (en)*2005-12-162006-01-25Novartis AgOrganic compounds
GB0525673D0 (en)*2005-12-162006-01-25Novartis AgOrganic compounds
TW200813067A (en)2006-05-172008-03-16Astrazeneca AbNicotinic acetylcholine receptor ligands

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