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EA202191641A1 - ANTIBODY-DRUG CONJUGATE COMBINATION WITH PARP INHIBITOR - Google Patents

ANTIBODY-DRUG CONJUGATE COMBINATION WITH PARP INHIBITOR

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Publication number
EA202191641A1
EA202191641A1EA202191641AEA202191641AEA202191641A1EA 202191641 A1EA202191641 A1EA 202191641A1EA 202191641 AEA202191641 AEA 202191641AEA 202191641 AEA202191641 AEA 202191641AEA 202191641 A1EA202191641 A1EA 202191641A1
Authority
EA
Eurasian Patent Office
Prior art keywords
antibody
drug conjugate
parp inhibitor
combination
conjugate combination
Prior art date
Application number
EA202191641A
Other languages
Russian (ru)
Inventor
Юсуке ОГИТАНИ
Даисуке ОКАДЗИМА
Юури Хасимото
Хирокадзу Судзуки
Original Assignee
Дайити Санкио Компани, Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дайити Санкио Компани, ЛимитедfiledCriticalДайити Санкио Компани, Лимитед
Publication of EA202191641A1publicationCriticalpatent/EA202191641A1/en

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Abstract

Translated fromRussian

Фармацевтическая композиция, где конъюгат антитело-лекарственное средство, в котором лекарственное средство-линкер, представленное нижеследующей формулой (где А представляет положение связывания с антителом), конъюгировано с антителом посредством тиоэфирной связи, и ингибитор PARP вводят в комбинации, и/или способ лечения, где конъюгат антитело-лекарственное средство и ингибитор PARP вводят индивидууму в комбинации.A pharmaceutical composition, wherein an antibody-drug conjugate, in which the drug-linker represented by the following formula (where A represents the binding position to the antibody) is conjugated to the antibody via a thioester bond, and the PARP inhibitor is administered in combination and / or a method of treatment, wherein the antibody-drug conjugate and PARP inhibitor are administered to the individual in combination.

EA202191641A2018-12-112019-12-10 ANTIBODY-DRUG CONJUGATE COMBINATION WITH PARP INHIBITOREA202191641A1 (en)

Applications Claiming Priority (2)

Application NumberPriority DateFiling DateTitle
JP20182319482018-12-11
PCT/JP2019/048171WO2020122034A1 (en)2018-12-112019-12-10Combination of antibody-drug conjugate with parp inhibitor

Publications (1)

Publication NumberPublication Date
EA202191641A1true EA202191641A1 (en)2021-09-13

Family

ID=71076370

Family Applications (1)

Application NumberTitlePriority DateFiling Date
EA202191641AEA202191641A1 (en)2018-12-112019-12-10 ANTIBODY-DRUG CONJUGATE COMBINATION WITH PARP INHIBITOR

Country Status (12)

CountryLink
US (1)US20220023436A1 (en)
EP (1)EP3909580A4 (en)
JP (2)JP7608164B2 (en)
KR (1)KR20210102341A (en)
CN (1)CN113271942A (en)
AU (1)AU2019396895B2 (en)
BR (1)BR112021011119A2 (en)
CA (1)CA3122946A1 (en)
EA (1)EA202191641A1 (en)
SG (1)SG11202106248XA (en)
TW (1)TW202034959A (en)
WO (1)WO2020122034A1 (en)

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WO2022248268A1 (en)*2021-05-282022-12-01Adc Therapeutics SaCombination therapy
US11806405B1 (en)2021-07-192023-11-07Zeno Management, Inc.Immunoconjugates and methods
US20250025568A1 (en)2021-11-182025-01-23Astrazeneca Uk LimitedCombination of antibody-drug conjugate and parp1 selective inhibitor
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Also Published As

Publication numberPublication date
SG11202106248XA (en)2021-07-29
EP3909580A1 (en)2021-11-17
KR20210102341A (en)2021-08-19
TW202034959A (en)2020-10-01
JPWO2020122034A1 (en)2021-10-28
AU2019396895A1 (en)2021-07-08
JP2025041725A (en)2025-03-26
US20220023436A1 (en)2022-01-27
CA3122946A1 (en)2020-06-18
AU2019396895B2 (en)2025-09-11
WO2020122034A1 (en)2020-06-18
EP3909580A4 (en)2022-09-07
JP7608164B2 (en)2025-01-06
CN113271942A (en)2021-08-17
BR112021011119A2 (en)2022-01-25

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