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EA201991684A1 - ATAZANAVIR ANALOGUES (ATV) FOR TREATING HIV INFECTIONS - Google Patents

ATAZANAVIR ANALOGUES (ATV) FOR TREATING HIV INFECTIONS

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Publication number
EA201991684A1
EA201991684A1EA201991684AEA201991684AEA201991684A1EA 201991684 A1EA201991684 A1EA 201991684A1EA 201991684 AEA201991684 AEA 201991684AEA 201991684 AEA201991684 AEA 201991684AEA 201991684 A1EA201991684 A1EA 201991684A1
Authority
EA
Eurasian Patent Office
Prior art keywords
formula
compound
atazanavir
atv
analogues
Prior art date
Application number
EA201991684A
Other languages
Russian (ru)
Inventor
Элизабет М. Бейкон
Элберт Чин
Джероми Дж. Коттелл
Эшли Энн Катана
Дэррил Като
Джон О. Линк
Натан Шапиро
Тереза Алехандра Трехо Мартин
Чжэн-Юй Ян
Original Assignee
Джилид Сайэнс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filedlitigationCriticalhttps://patents.darts-ip.com/?family=61244746&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201991684(A1)"Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Джилид Сайэнс, Инк.filedCriticalДжилид Сайэнс, Инк.
Publication of EA201991684A1publicationCriticalpatent/EA201991684A1/en

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Abstract

Translated fromRussian

В настоящем изобретении предложено соединение формулы (I) или его фармацевтически приемлемая соль, описанные в настоящем документе. В настоящем изобретении также предложены фармацевтические композиции, содержащие соединение формулы (I), способы получения соединений формулы (I), соединение формулы (I) для применения в терапевтических способах лечения пролиферации вируса иммунодефицита человека (ВИЧ), лечения синдрома приобретенного иммунодефицита (СПИДа) или задержки наступления симптомов СПИДа у млекопитающего с применением соединений формулы (I). Предпочтительными соединениями являются аналоги атазанавира (ATV), представляющего собой N-[(2S)-1-[2-[(2S,3S)-2-гидрокси-3-[[(2S)-2-(метоксикарбониламино)-3,3-диметилбутаноил]амино]-4-фенилбутил]-2-[(фенил)метил]гидразинил]-3,3-диметил-1-оксобутан-2-ил]карбамат, замещенные несколькими гетероциклами, такими как, например, пиразол (R), оксетан (заместитель при X), пиридин или пиримидин (X), пиперазин или 3,8-диазабицикло[3.2.1]октан (X).The present invention provides a compound of formula (I), or a pharmaceutically acceptable salt thereof, as described herein. The present invention also provides pharmaceutical compositions containing a compound of formula (I), methods for preparing compounds of formula (I), a compound of formula (I) for use in therapeutic methods for treating the proliferation of human immunodeficiency virus (HIV), treating acquired immunodeficiency syndrome (AIDS) or delaying the onset of AIDS symptoms in a mammal using compounds of formula (I). Preferred compounds are analogs of atazanavir (ATV), which is N - [(2S) -1- [2 - [(2S, 3S) -2-hydroxy-3 - [[(2S) -2- (methoxycarbonylamino) -3, 3-dimethylbutanoyl] amino] -4-phenylbutyl] -2 - [(phenyl) methyl] hydrazinyl] -3,3-dimethyl-1-oxobutan-2-yl] carbamate, substituted by several heterocycles such as, for example, pyrazole ( R), oxetane (substituent at X), pyridine or pyrimidine (X), piperazine or 3,8-diazabicyclo [3.2.1] octane (X).

EA201991684A2017-02-062018-02-05 ATAZANAVIR ANALOGUES (ATV) FOR TREATING HIV INFECTIONSEA201991684A1 (en)

Applications Claiming Priority (2)

Application NumberPriority DateFiling DateTitle
US201762455348P2017-02-062017-02-06
PCT/US2018/016893WO2018145021A1 (en)2017-02-062018-02-05Atazanavir (atv) analogues for treating hiv infections

Publications (1)

Publication NumberPublication Date
EA201991684A1true EA201991684A1 (en)2020-02-11

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ID=61244746

Family Applications (1)

Application NumberTitlePriority DateFiling Date
EA201991684AEA201991684A1 (en)2017-02-062018-02-05 ATAZANAVIR ANALOGUES (ATV) FOR TREATING HIV INFECTIONS

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US (5)US10294234B2 (en)
EP (2)EP3577110B1 (en)
JP (4)JP6814304B2 (en)
KR (4)KR20250008988A (en)
CN (3)CN110536889B (en)
AR (1)AR110922A1 (en)
AU (3)AU2018215546B2 (en)
CA (1)CA3051588C (en)
CL (1)CL2019002204A1 (en)
CO (1)CO2019008531A2 (en)
CR (1)CR20190354A (en)
CY (1)CY1124276T1 (en)
DK (1)DK3577110T3 (en)
DO (1)DOP2019000201A (en)
EA (1)EA201991684A1 (en)
ES (1)ES2877595T3 (en)
HR (1)HRP20210732T1 (en)
HU (1)HUE054690T2 (en)
IL (1)IL268282B2 (en)
JO (1)JOP20180009A1 (en)
LT (1)LT3577110T (en)
MX (2)MX2019009212A (en)
MY (2)MY207716A (en)
PE (1)PE20191260A1 (en)
PH (1)PH12019501786A1 (en)
PL (1)PL3577110T3 (en)
PT (1)PT3577110T (en)
SA (1)SA519402405B1 (en)
SG (1)SG11201907058TA (en)
SI (1)SI3577110T1 (en)
TW (4)TW202511265A (en)
UA (1)UA123298C2 (en)
UY (1)UY37592A (en)
WO (1)WO2018145021A1 (en)

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EP3577110B1 (en)2021-04-21
US20190308983A1 (en)2019-10-10
PH12019501786A1 (en)2020-06-29
IL268282B (en)2022-10-01
EP3909949B1 (en)2025-10-15
SG11201907058TA (en)2019-08-27
TW201840555A (en)2018-11-16
TW202043219A (en)2020-12-01
CA3051588A1 (en)2018-08-09
MX2022012616A (en)2022-11-07
DOP2019000201A (en)2019-08-30
KR102430812B1 (en)2022-08-11
CY1124276T1 (en)2022-07-22
PL3577110T3 (en)2021-10-25
IL268282B2 (en)2023-02-01
JP6814304B2 (en)2021-01-13
TWI794629B (en)2023-03-01
BR102018002152A8 (en)2022-11-16
SA519402405B1 (en)2024-03-03
IL268282A (en)2019-09-26
TW202344506A (en)2023-11-16
CN110536889B (en)2022-12-16
JP2021073287A (en)2021-05-13
US12084455B2 (en)2024-09-10
KR20230097222A (en)2023-06-30
HUE054690T2 (en)2021-09-28
US10752636B2 (en)2020-08-25
US20230027055A1 (en)2023-01-26
CO2019008531A2 (en)2019-10-31
EP3577110A1 (en)2019-12-11
PE20191260A1 (en)2019-09-18
AU2020264300A1 (en)2020-12-03
AU2022271510A1 (en)2023-01-05
JP7105853B2 (en)2022-07-25
ES2877595T3 (en)2021-11-17
CN110536889A (en)2019-12-03
JOP20180009A1 (en)2019-01-30
KR20250008988A (en)2025-01-16
CR20190354A (en)2019-09-19
MY200608A (en)2024-01-05
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