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Priority claimed from PCT/US2017/041946external-prioritypatent/WO2018013818A2/en
Publication of EA201990176A1publicationCriticalpatent/EA201990176A1/ru
C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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C07—ORGANIC CHEMISTRY
C07K—PEPTIDES
C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07K—PEPTIDES
C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07K—PEPTIDES
C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
C07K16/3046—Stomach, Intestines
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K39/00—Medicinal preparations containing antigens or antibodies
A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K39/00—Medicinal preparations containing antigens or antibodies
A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
A61K2039/507—Comprising a combination of two or more separate antibodies
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C07K2317/00—Immunoglobulins specific features
C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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C07K2317/00—Immunoglobulins specific features
C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
C—CHEMISTRY; METALLURGY
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C07K2317/00—Immunoglobulins specific features
C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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C07K2317/00—Immunoglobulins specific features
C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
C—CHEMISTRY; METALLURGY
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C07K2317/00—Immunoglobulins specific features
C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
C07K2317/41—Glycosylation, sialylation, or fucosylation
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C07—ORGANIC CHEMISTRY
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C07K2317/00—Immunoglobulins specific features
C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
C07K2317/52—Constant or Fc region; Isotype
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
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C07K2317/00—Immunoglobulins specific features
C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
C07K2317/55—Fab or Fab'
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07K—PEPTIDES
C07K2317/00—Immunoglobulins specific features
C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07K—PEPTIDES
C07K2317/00—Immunoglobulins specific features
C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
C07K2317/565—Complementarity determining region [CDR]
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C07K2317/00—Immunoglobulins specific features
C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
C07K2317/71—Decreased effector function due to an Fc-modification
C—CHEMISTRY; METALLURGY
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C07K2317/00—Immunoglobulins specific features
C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
C07K2317/74—Inducing cell proliferation
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C07K2317/00—Immunoglobulins specific features
C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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C07K2317/00—Immunoglobulins specific features
C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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C07—ORGANIC CHEMISTRY
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C07K2317/00—Immunoglobulins specific features
C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Anticuerpos anti antigeno leucocito 37 (cd37) biespecificos, anticuerpos anti antigeno leucocito 37 (cd37) monoclonales y metodos de uso de los mismos.