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DK3052628T3 - COMPOSITIONS AND PROCEDURES FOR INHIBITING EXPRESSION OF ALAS1 GENET - Google Patents

COMPOSITIONS AND PROCEDURES FOR INHIBITING EXPRESSION OF ALAS1 GENET
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DK3052628T3
DK3052628T3DK14800179.5TDK14800179TDK3052628T3DK 3052628 T3DK3052628 T3DK 3052628T3DK 14800179 TDK14800179 TDK 14800179TDK 3052628 T3DK3052628 T3DK 3052628T3
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alas1
genet
procedures
compositions
inhibiting expression
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DK14800179.5T
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Danish (da)
Inventor
Brian Bettencourt
Kevin Fitzgerald
William Querbes
Robert J Desnick
Makiko Yasuda
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Alnylam Pharmaceuticals Inc
Icahn School Med Mount Sinai
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DK14800179.5T2013-10-042014-10-03 COMPOSITIONS AND PROCEDURES FOR INHIBITING EXPRESSION OF ALAS1 GENETDK3052628T3 (en)

Applications Claiming Priority (3)

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US201361887288P2013-10-042013-10-04
US201461983720P2014-04-242014-04-24
PCT/US2014/059160WO2015051318A1 (en)2013-10-042014-10-03Compositions and methods for inhibiting expression of the alas1 gene

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DK3052628T3true DK3052628T3 (en)2020-06-02

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DK14800179.5TDK3052628T3 (en)2013-10-042014-10-03 COMPOSITIONS AND PROCEDURES FOR INHIBITING EXPRESSION OF ALAS1 GENET

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US (4)US10119143B2 (en)
EP (2)EP3052628B1 (en)
JP (3)JP6613227B2 (en)
KR (3)KR102469850B1 (en)
CN (1)CN105980559B (en)
AU (3)AU2014331604B2 (en)
BR (2)BR112016007226B1 (en)
CA (2)CA2925357C (en)
CL (2)CL2016000772A1 (en)
CR (1)CR20160195A (en)
CY (2)CY1122975T1 (en)
DK (1)DK3052628T3 (en)
DO (2)DOP2016000073A (en)
EA (1)EA036477B1 (en)
ES (1)ES2804510T3 (en)
GT (1)GT201600066A (en)
HR (1)HRP20200822T1 (en)
HU (2)HUE049227T2 (en)
IL (4)IL282747B2 (en)
LT (2)LT3052628T (en)
MX (2)MX390724B (en)
MY (2)MY197646A (en)
NL (1)NL301061I2 (en)
NO (1)NO2020029I1 (en)
NZ (2)NZ718995A (en)
PE (2)PE20211249A1 (en)
PH (1)PH12016500574A1 (en)
PL (1)PL3052628T3 (en)
PT (1)PT3052628T (en)
SG (2)SG10201910929QA (en)
SI (1)SI3052628T1 (en)
SM (1)SMT202000271T1 (en)
TN (1)TN2016000114A1 (en)
TW (3)TWI768330B (en)
UA (1)UA124961C2 (en)
WO (1)WO2015051318A1 (en)
ZA (2)ZA201602931B (en)

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US9133461B2 (en)2012-04-102015-09-15Alnylam Pharmaceuticals, Inc.Compositions and methods for inhibiting expression of the ALAS1 gene
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IL316808A (en)2014-08-202025-01-01Alnylam Pharmaceuticals IncModified double-stranded rna agents and uses thereof
WO2016061487A1 (en)2014-10-172016-04-21Alnylam Pharmaceuticals, Inc.Polynucleotide agents targeting aminolevulinic acid synthase-1 (alas1) and uses thereof
WO2017048843A1 (en)2015-09-142017-03-23Alnylam Pharmaceuticals, Inc.Compositions and methods for inhibiting expression of the alas1 gene
JP7288852B2 (en)2016-11-232023-06-08アルニラム・ファーマシューティカルズ・インコーポレーテッド Modified RNA agents with reduced off-target effects
WO2019136432A1 (en)2018-01-082019-07-11Novartis AgImmune-enhancing rnas for combination with chimeric antigen receptor therapy
JP2023515466A (en)*2020-02-212023-04-13アイオーニス ファーマシューティカルズ, インコーポレーテッド Method for reducing expression of HTT
EP4413378A1 (en)2021-10-062024-08-14Alnylam Pharmaceuticals, Inc.Renal injury biomarkers as biomarkers for acute hepatic porphyria (ahp)
AU2024206732A1 (en)*2023-01-062025-07-17Icahn School Of Medicine At Mount SinaiMethods for enhancing the efficacy of rnai therapy by targeting alas1/alas2
CN118460654B (en)*2024-07-102025-02-14凯莱英医药集团(天津)股份有限公司 A preparation method of Givosiran

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