Movatterモバイル変換


[0]ホーム

URL:


DK1568772T3 - Varianter af humant væksthormon - Google Patents

Varianter af humant væksthormon

Info

Publication number
DK1568772T3
DK1568772T3DK05007536.5TDK05007536TDK1568772T3DK 1568772 T3DK1568772 T3DK 1568772T3DK 05007536 TDK05007536 TDK 05007536TDK 1568772 T3DK1568772 T3DK 1568772T3
Authority
DK
Denmark
Prior art keywords
growth hormone
variants
human growth
disclosed
prolong
Prior art date
Application number
DK05007536.5T
Other languages
English (en)
Inventor
Brian C Cunningham
Ross G Clark
Henry B Lowman
Kenneth Olson
James A Wells
Germaine G Fuh
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filedlitigationCriticalhttps://patents.darts-ip.com/?family=27065361&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1568772(T3)"Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech IncfiledCriticalGenentech Inc
Application grantedgrantedCritical
Publication of DK1568772T3publicationCriticalpatent/DK1568772T3/da

Links

Classifications

Landscapes

DK05007536.5T1995-09-211996-09-20Varianter af humant væksthormonDK1568772T3 (da)

Applications Claiming Priority (3)

Application NumberPriority DateFiling DateTitle
US53706895A1995-09-211995-09-21
US53706795A1995-09-211995-09-21
EP96931597AEP0851925B1 (en)1995-09-211996-09-20Human growth hormone variants

Publications (1)

Publication NumberPublication Date
DK1568772T3true DK1568772T3 (da)2010-10-18

Family

ID=27065361

Family Applications (2)

Application NumberTitlePriority DateFiling Date
DK96931597TDK0851925T3 (da)1995-09-211996-09-20Humane Væksthormonvarianter
DK05007536.5TDK1568772T3 (da)1995-09-211996-09-20Varianter af humant væksthormon

Family Applications Before (1)

Application NumberTitlePriority DateFiling Date
DK96931597TDK0851925T3 (da)1995-09-211996-09-20Humane Væksthormonvarianter

Country Status (14)

CountryLink
US (4)US5849535A (da)
EP (3)EP0851925B1 (da)
JP (2)JP3628333B2 (da)
AT (2)ATE455171T1 (da)
AU (1)AU718439B2 (da)
CA (2)CA2658039A1 (da)
DE (5)DE69638117D1 (da)
DK (2)DK0851925T3 (da)
ES (2)ES2338431T3 (da)
HK (1)HK1012508A1 (da)
LU (1)LU91204I2 (da)
NL (1)NL300210I2 (da)
PT (1)PT1568772E (da)
WO (1)WO1997011178A1 (da)

Families Citing this family (220)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US5545553A (en)*1994-09-261996-08-13The Rockefeller UniversityGlycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them
US6753165B1 (en)*1999-01-142004-06-22Bolder Biotechnology, Inc.Methods for making proteins containing free cysteine residues
WO1999003887A1 (en)*1997-07-141999-01-28Bolder Biotechnology, Inc.Derivatives of growth hormone and related proteins
US7153943B2 (en)1997-07-142006-12-26Bolder Biotechnology, Inc.Derivatives of growth hormone and related proteins, and methods of use thereof
US20080076706A1 (en)1997-07-142008-03-27Bolder Biotechnology, Inc.Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof
US7270809B2 (en)*1997-07-142007-09-18Bolder Biotechnology, Inc.Cysteine variants of alpha interferon-2
US7495087B2 (en)1997-07-142009-02-24Bolder Biotechnology, Inc.Cysteine muteins in the C-D loop of human interleukin-11
US6639050B1 (en)1997-07-212003-10-28Ohio UniversitySynthetic genes for plant gums and other hydroxyproline-rich glycoproteins
US7378506B2 (en)1997-07-212008-05-27Ohio UniversitySynthetic genes for plant gums and other hydroxyproline-rich glycoproteins
US6570062B1 (en)*1997-07-212003-05-27Ohio UniversitySynthetic genes for plant gums and other hydroxyproline-rich glycoproteins
US6451986B1 (en)1998-06-222002-09-17Immunex CorporationSite specific protein modification
US20070212422A1 (en)*1999-11-102007-09-13Manfred KellerDry powder for inhalation
US6696063B1 (en)*1998-12-302004-02-24Applied Research Systems Ars Holding N.V.Treatment of HIV-associated dysmorphia/dysmetabolic syndrome (HADDS) with or without lipodystrophy
US8288126B2 (en)1999-01-142012-10-16Bolder Biotechnology, Inc.Methods for making proteins containing free cysteine residues
AU2008202371B2 (en)*1999-01-142012-08-02Bolder Biotechnology, Inc.Methods for making proteins containing free cysteine residues
WO2000068385A2 (en)*1999-05-122000-11-16Xencor, Inc.Novel nucleic acids and proteins with growth hormone activity
US6946265B1 (en)1999-05-122005-09-20Xencor, Inc.Nucleic acids and proteins with growth hormone activity
AT408721B (de)1999-10-012002-02-25Cistem Biotechnologies GmbhPharmazeutische zusammensetzung enthaltend ein antigen
EP1226173A1 (en)*1999-10-072002-07-31Maxygen ApsSingle-chain antagonist polypeptides
DE10005301A1 (de)*2000-02-072001-08-09Trutnau Hans HeinrichMulti-Schritt-Kinetik molekularer Interaktionen als analytisches Mess- und Auswerte-Verfahren
GB0011459D0 (en)*2000-05-122000-06-28Univ Wales MedicineSequences
AU5649901A (en)*2000-05-122001-11-20Univ Wales MedicineMethod for detecting growth hormone variations in humans, the variations and their uses
JP4873818B2 (ja)*2000-05-162012-02-08ボルダー バイオテクノロジー, インコーポレイテッド遊離システイン残基を含有するタンパク質をリフォールディングする方法
WO2001096565A2 (en)2000-06-162001-12-20Asterion LimitedBinding agents: chimeric ligand/receptor proteins
US20080194022A1 (en)*2000-08-032008-08-14Clarke Michael FIsolation and use of solid tumor stem cells
US6984522B2 (en)*2000-08-032006-01-10Regents Of The University Of MichiganIsolation and use of solid tumor stem cells
US8044259B2 (en)2000-08-032011-10-25The Regents Of The University Of MichiganDetermining the capability of a test compound to affect solid tumor stem cells
CA2418960A1 (en)2000-08-072002-02-14Inhale Therapeutic Systems, Inc.Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation
AU1384302A (en)*2000-11-102002-05-21Proteopharma ApsApolipoprotein analogues
AU2002219021A1 (en)*2001-01-112002-07-24Maxygen ApsVariant growth hormone molecules conjugated with macromolecular compounds
US20060183197A1 (en)*2001-01-112006-08-17Andersen Kim VVariant growth hormone molecules conjugated with macromolecules compounds
US7060675B2 (en)*2001-02-152006-06-13Nobex CorporationMethods of treating diabetes mellitus
US6867183B2 (en)*2001-02-152005-03-15Nobex CorporationPharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US6713452B2 (en)2001-06-042004-03-30Nobex CorporationMixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7713932B2 (en)2001-06-042010-05-11Biocon LimitedCalcitonin drug-oligomer conjugates, and uses thereof
US6835802B2 (en)2001-06-042004-12-28Nobex CorporationMethods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US6828305B2 (en)2001-06-042004-12-07Nobex CorporationMixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6858580B2 (en)*2001-06-042005-02-22Nobex CorporationMixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828297B2 (en)*2001-06-042004-12-07Nobex CorporationMixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
EP1402073B1 (en)*2001-06-052007-02-14Auckland Uniservices LimitedMethods and compositions for assessment of pulmonary function and disorders
CA3009793A1 (en)2001-06-142002-12-27The Regents Of The University Of CaliforniaMutations in the bcr-abl tyrosine kinase associated with resistance to sti-571
US7196059B2 (en)*2001-09-072007-03-27Biocon LimitedPharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US20040186051A1 (en)2001-10-022004-09-23Kelley Robert FApo-2 ligand variants and uses thereof
US6908963B2 (en)*2001-10-092005-06-21Nektar Therapeutics Al, CorporationThioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith
US7399613B2 (en)*2001-10-102008-07-15Neose Technologies, Inc.Sialic acid nucleotide sugars
US7795210B2 (en)2001-10-102010-09-14Novo Nordisk A/SProtein remodeling methods and proteins/peptides produced by the methods
US8008252B2 (en)2001-10-102011-08-30Novo Nordisk A/SFactor VII: remodeling and glycoconjugation of Factor VII
US7173003B2 (en)2001-10-102007-02-06Neose Technologies, Inc.Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
US7179617B2 (en)*2001-10-102007-02-20Neose Technologies, Inc.Factor IX: remolding and glycoconjugation of Factor IX
US7157277B2 (en)2001-11-282007-01-02Neose Technologies, Inc.Factor VIII remodeling and glycoconjugation of Factor VIII
EP2279753B1 (en)*2001-10-102015-09-16Novo Nordisk A/SRemodeling and glycoconjugation of peptides
US7696163B2 (en)2001-10-102010-04-13Novo Nordisk A/SErythropoietin: remodeling and glycoconjugation of erythropoietin
US7214660B2 (en)2001-10-102007-05-08Neose Technologies, Inc.Erythropoietin: remodeling and glycoconjugation of erythropoietin
US20040161802A1 (en)*2001-10-302004-08-19Applied Molecular EvolutionMethods for producing and improving therapeutic potency of binding polypeptides
JP2005508650A (ja)*2001-11-092005-04-07ファルマシア アンド アップジョン カンパニー リミティド ライアビリティー カンパニーGh−1における一塩基多型
US20050233417A1 (en)*2001-11-122005-10-20Cooper David NGrowth hormone variations in humans and their uses
US20030171285A1 (en)*2001-11-202003-09-11Finn Rory F.Chemically-modified human growth hormone conjugates
EP1453859A2 (en)*2001-11-202004-09-08Pharmacia CorporationChemically-modified human growth hormone conjugates
US7473680B2 (en)2001-11-282009-01-06Neose Technologies, Inc.Remodeling and glycoconjugation of peptides
GB2384001B (en)*2001-12-142004-02-04Asterion LtdChimeric growth hormone-growth hormone receptor proteins
WO2003105768A2 (en)2002-06-132003-12-24Nobex CorporationMethods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
MXPA04012496A (es)2002-06-212005-09-12Novo Nordisk Healthcare AgGlicoformos del factor vii pegilados.
JP4574350B2 (ja)2002-06-242010-11-04ジェネンテック, インコーポレイテッドApo−2リガンド/trail変異体とその使用法
US20040048315A1 (en)*2002-08-282004-03-11Pharmacia CorporationMethod for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities thereof
US20040121407A1 (en)*2002-09-062004-06-24Elixir Pharmaceuticals, Inc.Regulation of the growth hormone/IGF-1 axis
US7611700B2 (en)*2002-09-092009-11-03Hanall Pharmaceuticals, Co., Ltd.Protease resistant modified interferon alpha polypeptides
MXPA05003121A (es)*2002-09-202005-06-22Pharmacia CorpProcedimiento para disminuir los niveles de agregados de proteina polietilenglicosilada.
CN1703421B (zh)*2002-09-202010-06-23法玛西亚公司降低peg化蛋白的聚集体水平的方法
TWI281864B (en)*2002-11-202007-06-01Pharmacia CorpN-terminally monopegylated human growth hormone conjugates and process for their preparation
NZ525314A (en)*2002-12-192005-02-25Univ CardiffMethod and kit for diagnosing growth hormone dysfunction by determining SNP haplotypes of the proximal promoter region of the gene GH1
JP4686361B2 (ja)*2002-12-312011-05-25アルタス ファーマシューティカルズ インコーポレイテッドヒト成長ホルモンの結晶およびその調製方法
US7803777B2 (en)2003-03-142010-09-28Biogenerix AgBranched water-soluble polymers and their conjugates
WO2006127896A2 (en)*2005-05-252006-11-30Neose Technologies, Inc.Glycopegylated factor ix
US7691603B2 (en)*2003-04-092010-04-06Novo Nordisk A/SIntracellular formation of peptide conjugates
US8791070B2 (en)2003-04-092014-07-29Novo Nordisk A/SGlycopegylated factor IX
JP4674702B2 (ja)2003-04-092011-04-20バイオジェネリクス エージーグリコペギレ−ション法およびその方法により生成されたタンパク質/ペプチド
WO2004090135A2 (en)*2003-04-092004-10-21Asterion LimitedCytokine polypeptides and antibodies containing a signal sequence for the attachement of glycosylphosphatidylinositol
US20060252120A1 (en)*2003-05-092006-11-09Kieliszewski Marcia JSynthetic genes for plant gums and other hydroxyproline-rich glycoproteins
MXPA05011832A (es)2003-05-092006-02-17Neose Technologies IncComposiciones y metodos para la preparacion de mutantes de glicosilacion de la hormona de crecimiento humano.
JP2007516693A (ja)*2003-06-092007-06-28ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガン癌の治療および診断のための組成物および方法
GB0315182D0 (en)*2003-06-282003-08-06Asterion LtdCytokine variant polypeptides
WO2005012484A2 (en)2003-07-252005-02-10Neose Technologies, Inc.Antibody-toxin conjugates
GB0326632D0 (en)2003-11-142003-12-17Jagotec AgDry powder formulations
US20080305992A1 (en)*2003-11-242008-12-11Neose Technologies, Inc.Glycopegylated erythropoietin
US8633157B2 (en)2003-11-242014-01-21Novo Nordisk A/SGlycopegylated erythropoietin
US7842661B2 (en)2003-11-242010-11-30Novo Nordisk A/SGlycopegylated erythropoietin formulations
MXPA06005732A (es)*2003-11-242006-08-17Neose Technologies IncEritropoyetina glucopegilada.
US20080318850A1 (en)*2003-12-032008-12-25Neose Technologies, Inc.Glycopegylated Factor Ix
US7956032B2 (en)*2003-12-032011-06-07Novo Nordisk A/SGlycopegylated granulocyte colony stimulating factor
US20060040856A1 (en)*2003-12-032006-02-23Neose Technologies, Inc.Glycopegylated factor IX
KR101237884B1 (ko)*2003-12-032013-02-27바이오제너릭스 에이지글리코 peg화 과립구 콜로니 자극인자
US7338933B2 (en)*2004-01-082008-03-04Neose Technologies, Inc.O-linked glycosylation of peptides
WO2005069845A2 (en)*2004-01-142005-08-04Ohio UniversityMethods of producing peptides/proteins in plants and peptides/proteins produced thereby
MXPA06008209A (es)2004-01-212006-08-31Novo Nordisk AsConjugacion de peptidos mediada por transglutaminasa.
JP2007519422A (ja)2004-02-022007-07-19アンブレツクス・インコーポレイテツド修飾されたヒト四螺旋バンドルポリペプチド及びそれらの使用
JP2007526455A (ja)*2004-02-032007-09-13ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン癌を特徴付ける、制御する、診断する、および処置するための組成物ならびに方法
US20090203589A1 (en)*2004-02-092009-08-13Pfizer Inc.Chemically modified human growth hormone receptor antagonist conjugates
US20100028995A1 (en)*2004-02-232010-02-04Anaphore, Inc.Tetranectin Trimerizing Polypeptides
EP1751177A4 (en)2004-04-192008-07-16Univ Ohio CROSSLINKABLE GLYCOPROTEINS AND METHODS OF MAKING THE SAME
CN106434833A (zh)2004-05-232017-02-22杰勒德·M·豪斯Theramutein调节剂
US7820409B2 (en)*2004-06-232010-10-26Usv, Ltd.Chimeric human growth hormone derived from the placenta and pituitary isoform and processes for obtaining said chimera
CA2601716C (en)2004-06-252011-05-31Board Of Regents, The University Of Texas SystemMethods and compositions for the treatment of attention deficit hyperactivity disorder and hyperphenylalanemia
US20080300173A1 (en)2004-07-132008-12-04Defrees ShawnBranched Peg Remodeling and Glycosylation of Glucagon-Like Peptides-1 [Glp-1]
AU2005269753B2 (en)2004-07-192011-08-18Biocon LimitedInsulin-oligomer conjugates, formulations and uses thereof
MX2007001180A (es)*2004-07-262007-04-13Asterion LtdEnlazantes.
US7597884B2 (en)2004-08-092009-10-06Alios Biopharma, Inc.Hyperglycosylated polypeptide variants and methods of use
EP1799249A2 (en)2004-09-102007-06-27Neose Technologies, Inc.Glycopegylated interferon alpha
JP2008516621A (ja)*2004-10-182008-05-22ノボ ノルディスク アクティーゼルスカブ成長ホルモン結合体
DK2586456T3 (da)2004-10-292016-03-21Ratiopharm GmbhOmdannelse og glycopegylering af fibroblast vækstfaktor (FGF)
US7998930B2 (en)*2004-11-042011-08-16Hanall Biopharma Co., Ltd.Modified growth hormones
JP5110880B2 (ja)*2004-11-182012-12-26テルモ株式会社医薬組成物、製剤および組み合わせ製剤
CA2590462C (en)2004-12-222017-02-28Ambrx, Inc.Methods for expression and purification of recombinant human growth hormone
ATE542920T1 (de)*2004-12-222012-02-15Ambrx IncModifiziertes menschliches wachstumshormon
EP1833993A4 (en)2004-12-222009-07-22Ambrx Inc HUMAN GROWTH HORMONE FORMULATIONS COMPRISING AN AMINO ACID CODED NON-NATURALLY
EP1838332A1 (en)*2005-01-062007-10-03Neose Technologies, Inc.Glycoconjugation using saccharyl fragments
AU2006203792B2 (en)2005-01-102011-11-03Ratiopharm GmbhGlycopegylated Granulocyte Colony Stimulating Factor
US20060188498A1 (en)2005-02-182006-08-24Genentech, Inc.Methods of using death receptor agonists and EGFR inhibitors
US20090247421A1 (en)*2005-03-232009-10-01Egisto BoschettiDiverse chemical libraries bound to small particles with paramagnetic properties
CN101512013A (zh)*2005-03-232009-08-19生物-拉德实验室公司与具有顺磁性质的小颗粒相连接的各种化学库
CA2602951A1 (en)*2005-03-232006-09-28Bio-Rad Laboratories, Inc.Diverse chemical libraries bound to small particles with paramagnetic properties
EP1861125A2 (en)*2005-03-232007-12-05Nektar Therapeutics Al, CorporationConjugates of an hgh moiety and peg derivatives
EP1866427A4 (en)*2005-03-302010-09-01Novo Nordisk As METHOD OF MANUFACTURING PEPTIDES PRODUCED IN INSECT CELL LINES
US9187546B2 (en)2005-04-082015-11-17Novo Nordisk A/SCompositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
CN101163505A (zh)*2005-04-132008-04-16伊拉斯谟大学鹿特丹医药中心使用gh拮抗剂和生长抑素激动剂的治疗方法
AU2006244683A1 (en)*2005-05-102006-11-16Synergenz Bioscience LimitedMethods and compositions for assessment of pulmonary function and disorders
CA2608161A1 (en)*2005-05-192006-11-23Synergenz Bioscience LimitedMethods for the assesssment of risk of developing lung cancer using analysis of genetic polymorphisms
EP1888779A4 (en)*2005-05-202009-06-10Synergenz Bioscience Ltd METHOD FOR THE ANALYSIS OF POLYMORPHISMS AND USES THEREOF
US8431110B2 (en)2005-05-232013-04-30Hmi Medical Innovations, Llc.Compounds and method of identifying, synthesizing, optimizing and profiling protein modulators
WO2006135886A2 (en)*2005-06-132006-12-21The Regents Of The University Of MichiganCompositions and methods for treating and diagnosing cancer
US7576053B2 (en)2005-06-132009-08-18Rigel Pharmaceuticals, Inc.Methods and compositions for treating degenerative bone disorders
WO2007008708A2 (en)*2005-07-082007-01-18Ohio UniversityMethods of predicting hyp-glycosylation sites for proteins expressed and secreted in plant cells, and related methods and products
MX2008002395A (es)*2005-08-192008-03-18Neose Technologies IncFactor vii y factor viia glicopegilados.
US20070105755A1 (en)2005-10-262007-05-10Neose Technologies, Inc.One pot desialylation and glycopegylation of therapeutic peptides
US7855279B2 (en)2005-09-272010-12-21Amunix Operating, Inc.Unstructured recombinant polymers and uses thereof
WO2007041614A2 (en)*2005-10-032007-04-12Bolder Biotechnology, Inc.Long acting vegf inhibitors and methods of use
US7723477B2 (en)2005-10-312010-05-25Oncomed Pharmaceuticals, Inc.Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
JP5129149B2 (ja)*2005-10-312013-01-23ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン癌を処置および診断するための組成物および方法
ME02226B (me)2005-10-312016-02-20Oncomed Pharm IncSastavi i postupci za dijagnozu i tretman raka
US20090048440A1 (en)2005-11-032009-02-19Neose Technologies, Inc.Nucleotide Sugar Purification Using Membranes
US20090275070A1 (en)2005-11-232009-11-05Housey Gerard MCompounds and Methods of Identifying, Synthesizing, Optimizing and Profiling Protein Modulators
US20130172274A1 (en)*2005-12-202013-07-04Duke UniversityMethods and compositions for delivering active agents with enhanced pharmacological properties
US8841255B2 (en)2005-12-202014-09-23Duke UniversityTherapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides
EP1976551A4 (en)*2005-12-232009-12-30Altus Pharmaceuticals Inc COMPOSITIONS COMPRISING COMPLEX PROTEIN CRYSTALS BY POLYCATIONS AND PROCESSING METHOD THEREOF
GB0602897D0 (en)*2006-02-132006-03-22Jagotec AgImprovements In Or Relating To Dry Powder Inhaler Devices
WO2007100640A2 (en)*2006-02-212007-09-07The Regents Of The University Of MichiganGrowth hormone receptor antagonist cancer treatment
GB0606946D0 (en)*2006-04-062006-05-17Asterion LtdPolypeptide antagonist
US7534595B2 (en)*2006-06-122009-05-19Biomarin Pharmaceutical Inc.Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof
US7531341B1 (en)2006-06-122009-05-12Biomarin Pharmaceutical Inc.Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof
US20080064039A1 (en)*2006-07-062008-03-13Pienkos Philip TDominant negative ligand drug discovery system
US20080248959A1 (en)*2006-07-212008-10-09Neose Technologies, Inc.Glycosylation of peptides via o-linked glycosylation sequences
JP2010505874A (ja)*2006-10-032010-02-25ノヴォ ノルディスク アー/エスポリペプチドコンジュゲートの精製方法
MX2009003470A (es)*2006-10-042009-04-14Novo Nordisk AsAzucares y glicopeptidos pegilados enlazados a glicerol.
US20080207487A1 (en)*2006-11-022008-08-28Neose Technologies, Inc.Manufacturing process for the production of polypeptides expressed in insect cell-lines
GB0622818D0 (en)*2006-11-152006-12-27Jagotec AgImprovements in or relating to organic compounds
EP2102355B1 (en)*2006-12-142016-03-02Bolder Biotechnology, Inc.Long acting proteins and peptides and methods of making and using the same
GB0625303D0 (en)*2006-12-192007-01-24Jagotec AgImprovements in and relating to metered dose inhalers
WO2008092002A2 (en)*2007-01-242008-07-31The Regents Of The University Of MichiganCompositions and methods for treating and diagnosing pancreatic cancer
JP2010523582A (ja)2007-04-032010-07-15バイオジェネリクス アクチェンゲゼルシャフトグリコpeg化g−csfを用いた治療方法
US20090053167A1 (en)*2007-05-142009-02-26Neose Technologies, Inc.C-, S- and N-glycosylation of peptides
CA2690611C (en)2007-06-122015-12-08Novo Nordisk A/SImproved process for the production of nucleotide sugars
US7560263B2 (en)*2007-08-172009-07-14Biomarin Pharmaceutical Inc.Compositions of prokaryotic phenylalanine ammonia-lyase and methods of treating cancer using compositions thereof
US8207112B2 (en)2007-08-292012-06-26Biogenerix AgLiquid formulation of G-CSF conjugate
EP2195333A1 (en)*2007-09-122010-06-16Anaphore, Inc.Hsp70-based treatment for autoimmune diseases
GB0719818D0 (en)*2007-10-112007-11-21Asterion LtdGrowth hormone fusion polypeptides
ES2664822T3 (es)2007-10-162018-04-23Biocon LimitedUna composición farmacéutica sólida administrable por vía oral y un proceso de la misma
EP2225269A2 (en)*2007-11-092010-09-08Anaphore, Inc.Fusion proteins of mannose binding lectins for treatment of disease
US9938333B2 (en)2008-02-082018-04-10Ambrx, Inc.Modified leptin polypeptides and their uses
JP5619630B2 (ja)2008-02-272014-11-05ノボ・ノルデイスク・エー/エス結合型第viii因子分子
CN105727261A (zh)2008-06-272016-07-06杜克大学包含弹性蛋白样肽的治疗剂
US20110201022A1 (en)2008-07-302011-08-18Biomarin Pharmaceutical Inc.Assays for detection of phenylalanine ammonia-lyase and antibodies to phenylalanine ammonia-lyase
EP2323694A1 (en)*2008-08-062011-05-25Novo Nordisk Health Care AGConjugated proteins with prolonged in vivo efficacy
ES2663536T3 (es)2008-09-262018-04-13Oncomed Pharmaceuticals, Inc.Agentes que se unen a receptores frizzled y usos de los mismos
AU2009303304A1 (en)2008-10-102010-04-15Anaphore, Inc.Polypeptides that bind TRAIL-RI and TRAIL-R2
AU2010207725B2 (en)2009-01-222015-06-11Novo Nordisk Health Care AgStable growth hormone compounds
US8703717B2 (en)2009-02-032014-04-22Amunix Operating Inc.Growth hormone polypeptides and methods of making and using same
LT2393828T (lt)2009-02-032017-01-25Amunix Operating Inc.Prailginti rekombinantiniai polipeptidai ir juos apimančios kompozicijos
US8680050B2 (en)2009-02-032014-03-25Amunix Operating Inc.Growth hormone polypeptides fused to extended recombinant polypeptides and methods of making and using same
US9849188B2 (en)2009-06-082017-12-26Amunix Operating Inc.Growth hormone polypeptides and methods of making and using same
US8445953B2 (en)2009-07-082013-05-21Taiwan Semiconductor Manufacturing Company, Ltd.Structure for flash memory cells
CN102612376A (zh)2009-08-062012-07-25诺沃-诺迪斯克保健股份有限公司具有延长的体内功效的生长激素
CA2777162A1 (en)*2009-10-092011-04-14Anaphore, Inc.Polypeptides that bind il-23r
US20110086806A1 (en)*2009-10-092011-04-14Anaphore, Inc.Polypeptides that Bind IL-23R
EP2332929A1 (en)2009-11-252011-06-15ArisGen SAOrthoester derivatives of crown ethers as carriers for pharmaceutical and diagnostic compositions
TWI535445B (zh)2010-01-122016-06-01安可美德藥物股份有限公司Wnt拮抗劑及治療和篩選方法
SI2525834T1 (sl)2010-01-222019-10-30Novo Nordisk Healthcare AgRastni hormoni s podaljšano in vivo učinkovitostjo
MX338357B (es)2010-01-222016-04-13Novo Nordisk Healthcare AgCompuestos estables de la hormona de crecimiento.
EP4062928A3 (en)2010-02-042022-11-30BioMarin Pharmaceutical Inc.Prokaryotic phenylalanine ammonia-lyases and their use for treating phenylketonuria and hyperphenylalaninemia
CA2794674A1 (en)2010-04-012011-10-06Oncomed Pharmaceuticals, Inc.Frizzled-binding agents and uses thereof
ES2632348T3 (es)2010-04-282017-09-12University Of Southern CaliforniaDéficit de receptores de la hormona del crecimiento como causa de una reducción significativa de la señalización pro-envejecimiento, del cáncer y de la diabetes
EP2595661A1 (en)2010-07-222013-05-29Novo Nordisk Health Care AGGrowth hormone conjugates
EP2446898A1 (en)2010-09-302012-05-02Laboratorios Del. Dr. Esteve, S.A.Use of growth hormone to enhance the immune response in immunosuppressed patients
CA2834776A1 (en)2011-05-032012-11-08Genentech, Inc.Therapeutic apo2l/trail polypeptides and death receptor agonist antibodies
EP2526971A1 (en)2011-05-252012-11-28ArisGen SAMucosal delivery of drugs
AU2013214698B2 (en)2012-02-032017-02-16Antisense Therapeutics LtdCombination therapy comprising a growth hormone variant and an oligonucleotide targeted to the growth hormone receptor
WO2013119800A1 (en)2012-02-072013-08-15Massachusetts Institute Of TechnologyUse of antagonists of ghrelin or ghrelin receptor to prevent or treat stress-sensitive psychiatric illness
EP2911691B1 (en)2012-10-232018-10-10OncoMed Pharmaceuticals, Inc.Methods of treating neuroendocrine tumors using wnt pathway-binding agents
CA2899353A1 (en)2013-02-042014-08-07Oncomed Pharmaceuticals, Inc.Methods and monitoring of treatment with a wnt pathway inhibitor
EP2970506A1 (en)*2013-03-112016-01-20Novo Nordisk Health Care AGGrowth hormone compounds
CN105229035A (zh)*2013-03-112016-01-06诺和诺德保健股份有限公司生长激素化合物
US9168300B2 (en)2013-03-142015-10-27Oncomed Pharmaceuticals, Inc.MET-binding agents and uses thereof
US9724396B2 (en)2013-03-152017-08-08Massachusetts Institute Of TechnologyUse of antagonists of growth hormone or growth hormone receptor to prevent or treat stress-sensitive psychiatric illness
WO2014166836A1 (en)2013-04-052014-10-16Novo Nordisk A/SGrowth hormone compound formulation
BR112016002845A2 (pt)2013-08-122017-09-12Genentech Inccomposições e métodos para tratar condições associadas ao complemento
BR112016025312A2 (pt)2014-05-012017-10-17Genentech Incvariantes de anticorpo, anticorpo anti-fator d, formulação farmacêutica, dispositivo de distribuição, utilização da formulação e de uma composição, composição e método de tratamento de uma desordem
CN104693433B (zh)*2015-02-042017-06-06国家纳米科学中心一种聚乙二醇化氨磷汀、制备方法及其用途
US10317418B2 (en)2015-02-242019-06-11Massachusetts Institute Of TechnologyUse of ghrelin or functional ghrelin receptor agonists to prevent and treat stress-sensitive psychiatric illness
CN107743494B (zh)2015-06-022022-04-29诺和诺德股份有限公司具有极性重组延伸体的胰岛素
MA43348A (fr)2015-10-012018-08-08Novo Nordisk AsConjugués de protéines
EP3368074A2 (en)2015-10-302018-09-05Hoffmann-La Roche AGAnti-factor d antibodies and conjugates
JP2018536650A (ja)2015-10-302018-12-13ジェネンテック, インコーポレイテッド抗d因子抗体変異体コンジュゲート及びその使用
GB201520021D0 (en)2015-11-132015-12-30Asterion LtdFusion polypeptide
WO2018185131A2 (en)2017-04-052018-10-11Novo Nordisk A/SOligomer extended insulin-fc conjugates
WO2019125002A1 (ko)*2017-12-202019-06-27(주)알테오젠신규한 성장 호르몬 수용체 길항제 및 이의 융합 단백질
KR102167827B1 (ko)*2017-12-202020-10-20주식회사 알테오젠신규한 성장 호르몬 수용체 길항제 및 이의 융합 단백질
WO2019211842A1 (en)*2018-04-302019-11-07Opko Biologics Ltd.Long-acting human growth hormone-antagonists and methods of producing the same
CA3141128A1 (en)2019-06-172020-12-24Molecular Technologies Laboratories LlcTherapeutic pegylated growth hormone antagonists
JP2023519213A (ja)2020-03-242023-05-10ジェネンテック, インコーポレイテッドTie2結合剤および使用方法
AU2023314508A1 (en)2022-07-292024-11-14University Of RochesterMethods for improving muscle mass, strength, or function with a combination of testosterone and growth hormone
TW202448921A (zh)2023-05-122024-12-16丹麥商諾佛 儂迪克股份有限公司長效生長激素受體拮抗劑及其用途
KR20240172522A (ko)*2023-06-012024-12-10(주)알테오젠지속형 호르몬 수용체 길항제의 생산 방법

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US3853832A (en)*1971-04-271974-12-10Harmone Res FoundationSynthetic human pituitary growth hormone and method of producing it
US3853833A (en)*1971-04-271974-12-10Hormone Res FoundationSynthetic human growth-promoting and lactogenic hormones and method of producing same
US4880910A (en)*1981-09-181989-11-14Genentech, Inc.Terminal methionyl bovine growth hormone and its use
US4446235A (en)*1982-03-221984-05-01Genentech, Inc.Method for cloning human growth hormone varient genes
US4670393A (en)*1982-03-221987-06-02Genentech, Inc.DNA vectors encoding a novel human growth hormone-variant protein
US4665160A (en)*1982-03-221987-05-12Genentech, Inc.Novel human growth hormone like protein HGH-V encoded in the human genome
US4699897A (en)*1983-06-041987-10-13AmgenBiologically active peptides structurally related to regions within growth hormones
BG49718A3 (en)*1983-07-151992-01-15Bio- Technology General CorpMethod for preparing of polypeptid with superoxiddismutasne activitty
US4888286A (en)*1984-02-061989-12-19Creative Biomolecules, Inc.Production of gene and protein analogs through synthetic gene design using double stranded synthetic oligonucleotides
JPH01502640A (ja)*1987-03-121989-09-14アムジエン・インコーポレーテツドウシ成長ホルモン類似体
ATE84313T1 (de)*1987-04-021993-01-15Genentech IncSubstratunterstuetzte katalyse.
US5223409A (en)*1988-09-021993-06-29Protein Engineering Corp.Directed evolution of novel binding proteins
EP0768377A1 (en)*1988-09-021997-04-16Protein Engineering CorporationGeneration and selection of recombinant varied binding proteins
CA2001774C (en)*1988-10-282001-10-16James A. WellsMethod for identifying active domains and amino acid residues in polypeptides and hormone variants
US5534617A (en)*1988-10-281996-07-09Genentech, Inc.Human growth hormone variants having greater affinity for human growth hormone receptor at site 1
EP0441889A1 (fr)*1988-11-071991-08-21Commission des Communautés EuropéennesHormone de croissance humaine modifiee
WO1990008823A1 (en)*1989-01-311990-08-09The Upjohn CompanySomatotropin analogs
US5350836A (en)*1989-10-121994-09-27Ohio UniversityGrowth hormone antagonists
GB9015198D0 (en)*1990-07-101990-08-29Brien Caroline J OBinding substance
ES2113940T3 (es)*1990-12-031998-05-16Genentech IncMetodo de enriquecimiento para variantes de proteinas con propiedades de union alteradas.
EP0659213A1 (en)*1991-05-011995-06-28Ohio UniversityGrowth hormone antagonists
EP0586549B1 (en)*1991-05-102000-09-20Genentech, Inc.Selecting ligand agonists and antagonists
AU2147192A (en)*1991-06-281993-01-25Genentech Inc.Method of stimulating immune response using growth hormone
AU7877194A (en)*1993-09-221995-04-10American Cyanamid CompanyPorcine somatotropin having enhanced stability; process for producing
AU6255096A (en)*1995-06-071996-12-30Mount Sinai School Of Medicine Of The City University Of New York, ThePegylated modified proteins
AU5881996A (en)*1995-06-071996-12-30Ohio University/Edison Biotechnology InstituteMethods of treatment using growth hormone antagonists

Also Published As

Publication numberPublication date
WO1997011178A1 (en)1997-03-27
EP1568772B1 (en)2010-01-13
ATE301196T1 (de)2005-08-15
US5849535A (en)1998-12-15
DK0851925T3 (da)2005-11-28
ES2190388T3 (es)2006-04-01
EP1568771A3 (en)2006-05-17
AU7073396A (en)1997-04-09
ES2338431T3 (es)2010-05-07
NL300210I1 (nl)2006-02-01
LU91204I2 (fr)2006-02-06
DE851925T1 (de)2003-08-14
DE122006000003I2 (de)2011-01-13
DE69635026T2 (de)2006-05-24
JP2005021157A (ja)2005-01-27
EP1568771A2 (en)2005-08-31
JP3693668B2 (ja)2005-09-07
EP1568772A3 (en)2006-05-17
US6057292A (en)2000-05-02
ES2190388T1 (es)2003-08-01
DE69635026D1 (de)2005-09-08
DE122006000003I1 (de)2006-05-04
AU718439B2 (en)2000-04-13
CA2230492C (en)2009-05-26
JP3628333B2 (ja)2005-03-09
EP0851925B1 (en)2005-08-03
CA2658039A1 (en)1997-03-27
HK1012508A1 (en)1999-08-06
PT1568772E (pt)2010-04-14
CA2230492A1 (en)1997-03-27
US6136563A (en)2000-10-24
NL300210I2 (nl)2007-05-01
EP0851925A1 (en)1998-07-08
US6004931A (en)1999-12-21
JPH11512298A (ja)1999-10-26
DE69638117D1 (de)2010-03-04
ATE455171T1 (de)2010-01-15
EP1568772A2 (en)2005-08-31

Similar Documents

PublicationPublication DateTitle
DK1568772T3 (da)Varianter af humant væksthormon
ES2063278T3 (es)Proteina morfogenetica de hueso.
IL149459A0 (en)Recombinant gelatins
PE14199A1 (es)Agonistas de 5-ht1f
PT934325E (pt)Trisanidridos biciclicos de tetrafosfonato
ATE186736T1 (de)Aza-zyklohexapeptide
ATE239789T1 (de)Chimäre prokoagulierende proteine
ID25478A (id)Agonis 5-ht1f
BR9307097A (pt)Composição polimérica flexível e isenta de halogênio
DK598687A (da)Detergentkomposition
BR9704377A (pt)Composições de borracha contendo n,n'-bis (hidroxifenil) maleamida
JO1999B1 (en) Isotopes of the hormone 'LH-RH' have their uses and the chemical compounds they contain
BR9710992A (pt)Derivados anticovulsivos úteis no tratamento de psorìase
BR9902081A (pt)Combinação de dofetilida e um bloqueador dos canais de cálcio
ITPD960085A0 (it)Pattini da neve con possibilita' di regolazione istantanea della velocita' utilizzabili anche come racchette da neve.
IT8682573A0 (it)Dispositivo di regolazione dell'appoggio tibiale, particolarmente per scarponi da sci.

[8]ページ先頭

©2009-2025 Movatter.jp