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DE69638077D1 - Bacterial production of interferon-beta polypeptides - Google Patents

Bacterial production of interferon-beta polypeptides

Info

Publication number
DE69638077D1
DE69638077D1DE69638077TDE69638077TDE69638077D1DE 69638077 D1DE69638077 D1DE 69638077D1DE 69638077 TDE69638077 TDE 69638077TDE 69638077 TDE69638077 TDE 69638077TDE 69638077 D1DE69638077 D1DE 69638077D1
Authority
DE
Germany
Prior art keywords
interferon
beta polypeptides
bacterial production
beta
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69638077T
Other languages
German (de)
Inventor
Glenn Dorin
Patrick J Mcalary
Kathleen M Wong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Novartis Vaccines and Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Vaccines and Diagnostics IncfiledCriticalNovartis Vaccines and Diagnostics Inc
Application grantedgrantedCritical
Publication of DE69638077D1publicationCriticalpatent/DE69638077D1/en
Anticipated expirationlegal-statusCritical
Expired - Fee Relatedlegal-statusCriticalCurrent

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Abstract

Methods for the production of interferon- beta polypeptides by bacterial cells, by culturing cells capable of producing IFN- beta polypeptide under conditions that induce increased production of IFN- beta polypeptide. Such conditions include, for example, low potassium cation concentration and/or very low sodium cation concentration and/or specific pH ranges.
DE69638077T1995-06-061996-06-05 Bacterial production of interferon-beta polypeptidesExpired - Fee RelatedDE69638077D1 (en)

Applications Claiming Priority (2)

Application NumberPriority DateFiling DateTitle
US08/477,310US5814485A (en)1995-06-061995-06-06Production of interferon-β (IFN-β) in E. coli
PCT/US1996/009155WO1996039523A2 (en)1995-06-061996-06-05Bacterial production of hydrophobic polypeptides

Publications (1)

Publication NumberPublication Date
DE69638077D1true DE69638077D1 (en)2009-12-31

Family

ID=23895395

Family Applications (1)

Application NumberTitlePriority DateFiling Date
DE69638077TExpired - Fee RelatedDE69638077D1 (en)1995-06-061996-06-05 Bacterial production of interferon-beta polypeptides

Country Status (17)

CountryLink
US (1)US5814485A (en)
EP (1)EP0778893B1 (en)
JP (3)JP4131554B2 (en)
AT (1)ATE449175T1 (en)
AU (1)AU6154996A (en)
BR (1)BR9606491A (en)
CA (1)CA2195799C (en)
DE (1)DE69638077D1 (en)
FI (1)FI970445L (en)
IL (1)IL120009A0 (en)
IN (1)IN190514B (en)
MX (1)MX9700818A (en)
MY (1)MY118492A (en)
NO (1)NO324529B1 (en)
NZ (1)NZ310710A (en)
TW (1)TW494138B (en)
WO (1)WO1996039523A2 (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
AU6399996A (en)*1996-06-191998-01-07Chiron CorporationBacterial production of interferon-beta using low levels of sodium and potassium ions
US6514729B1 (en)1999-05-122003-02-04Xencor, Inc.Recombinant interferon-beta muteins
RU2180687C1 (en)*2000-07-052002-03-20Общество с ограниченной ответственностью "Биотех"Yeast strain pichia pastoris as producer of human fibroblast interferon, recombinant plasmid dna phis and method of its construction
US7544354B2 (en)*2000-10-272009-06-09Novartis Vaccines And DiagnosticsMethods of protein purification and recovery
WO2002042336A2 (en)*2000-11-212002-05-30The Texas A & M University SystemFgf-affinity chromatography
JPWO2002043752A1 (en)*2000-11-292004-04-02森永乳業株式会社 Interferon therapeutic effect enhancer
US6887462B2 (en)2001-04-092005-05-03Chiron CorporationHSA-free formulations of interferon-beta
AR034749A1 (en)*2001-07-092004-03-17Schering Ag FORMULATIONS OF HUMAN BETA INTERFERON
WO2004022593A2 (en)*2002-09-092004-03-18Nautilus BiotechRational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
MXPA06000460A (en)*2003-07-112006-04-07Schering AgIMPROVED RECOMBINANT HUMAN INTERFERON-BETA-1b POLYPEPTIDES.
CA2547822A1 (en)*2003-12-112005-06-30Ares Trading S.A.Stabilized interferon liquid formulations
AU2005211385B2 (en)2004-02-022008-12-11Ambrx, Inc.Modified human growth hormone polypeptides and their uses
WO2006122972A1 (en)*2005-05-192006-11-23Bayer Schering Pharma AktiengesellschaftInterferon-beta gene therapy using an improved, regulated expression system
US20080076729A1 (en)*2005-05-192008-03-27Schering AktiengesellachaftInterferon-beta gene therapy using an improved, regulated expression system
JP2008545639A (en)*2005-05-192008-12-18バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト Treatment of diseases using an improved regulated expression system
US20070179113A1 (en)*2005-05-192007-08-02Schering AktiengesellachaftGM-CSF gene therapy for Crohn's disease using an improved regulated expression system
US20080038224A1 (en)*2006-03-282008-02-14Thierry GuyonModified interferon-beta (IFN-beta) polypeptides
AU2007351813B2 (en)2006-10-312013-10-10East Carolina UniversityFusion proteins comprising an anti-inflammatory cytokine and an antigen for treatment of immune disorders
WO2008125222A2 (en)*2007-04-112008-10-23Bayer Schering Pharma AktiengesellschaftNew modulation molecules for an improved regulated expression system
CA2685596A1 (en)2007-05-022008-11-13Ambrx, Inc.Modified interferon beta polypeptides and their uses
WO2009045553A1 (en)*2007-10-052009-04-09Barofold, Inc.High pressure treatment of aggregated interferons
AU2008340058A1 (en)*2007-12-202009-07-02Merck Serono S.A.PEG-interferon-beta formulations
US9938333B2 (en)2008-02-082018-04-10Ambrx, Inc.Modified leptin polypeptides and their uses
KR20090124204A (en)*2008-05-292009-12-03(주)바이오큐어팜 Recombinant Escherichia coli and a method for producing the recombinant human mutant interferon-beta protein from which amino-terminal methionine has been removed
WO2010117848A1 (en)2009-03-312010-10-14East Carolina UniversityCytokines and neuroantigens for treatment of immune disorders
JP5830032B2 (en)*2010-02-012015-12-09ディグナ ビオテク、エセ エレＤｉｇｎａ Ｂｉｏｔｅｃｈ，Ｓ．Ｌ． Method for producing interferon alpha 5
EP2542574B1 (en)2010-03-042017-08-09Pfenex Inc.Method for producing soluble recombinant interferon protein without denaturing
RU2473696C1 (en)*2011-07-142013-01-27Закрытое акционерное общество "ГЕНЕРИУМ"INDUSTRIAL METHOD OF PRODUCING AND PURIFYING RECOMBINANT HUMAN INTERFERON β-1b FROM INCLUSION BODIES
JP6363326B2 (en)*2013-03-112018-07-25株式会社コーセー Yeast / bacteria common culture method and yeast / bacteria common culture medium used therefor
JP7151049B2 (en)*2018-03-302022-10-12三井化学株式会社 How to grow microorganisms

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US4499188A (en)*1982-05-051985-02-12Cetus CorporationBacterial production of heterologous polypeptides under the control of a repressible promoter-operator
FI82266C (en)*1982-10-191991-02-11Cetus Corp FOERFARANDE FOER FRAMSTAELLNING AV IL-2 MUTEIN.
US4518584A (en)*1983-04-151985-05-21Cetus CorporationHuman recombinant interleukin-2 muteins
JPS60118196A (en)*1983-11-301985-06-25Takeda Chem Ind LtdProduction of interferon
US4656132A (en)*1984-03-281987-04-07Cetus CorporationMethod of improving the yield of heterologous protein produced by cultivating recombinant bacteria
JPH0755152B2 (en)*1986-06-021995-06-14日本化薬株式会社 Recombinant gene product manufacturing method and medium

Also Published As

Publication numberPublication date
ATE449175T1 (en)2009-12-15
EP0778893B1 (en)2009-11-18
IL120009A0 (en)1997-04-15
TW494138B (en)2002-07-11
WO1996039523A2 (en)1996-12-12
JP4131554B2 (en)2008-08-13
JP4317890B2 (en)2009-08-19
IN190514B (en)2003-08-02
US5814485A (en)1998-09-29
EP0778893A2 (en)1997-06-18
NZ310710A (en)1999-01-28
WO1996039523A3 (en)1997-01-30
JP2008283988A (en)2008-11-27
JP2008086331A (en)2008-04-17
FI970445A0 (en)1997-02-03
FI970445A7 (en)1997-03-26
JPH11501820A (en)1999-02-16
CA2195799A1 (en)1996-12-12
AU6154996A (en)1996-12-24
MY118492A (en)2004-11-30
FI970445L (en)1997-03-26
NO970514D0 (en)1997-02-05
NO324529B1 (en)2007-11-12
CA2195799C (en)2010-02-09
BR9606491A (en)1997-09-02
MX9700818A (en)1997-05-31
NO970514L (en)1997-03-17

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Legal Events

DateCodeTitleDescription
8364No opposition during term of opposition
8339Ceased/non-payment of the annual fee
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