DE69018215D1 - Process for the production of optically active atenolol and intermediate product thereof. - Google Patents

Process for the production of optically active atenolol and intermediate product thereof.

Info

Publication number: DE69018215D1
Authority: DE; Germany
Prior art keywords: production; optically active; intermediate product; active atenolol; atenolol
Prior art date: 1989-12-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Other versions

Inventor

Yoshikazu Takehira

Nobuaki Saragai

Kazuhiro Kitaori

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Osaka Soda Co Ltd

Original Assignee

Daiso Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-27

Filing date

1990-12-12

Publication date

1995-05-04

1990-12-12Application filed by Daiso Co LtdfiledCriticalDaiso Co Ltd

1995-05-04Publication of DE69018215D1publicationCriticalpatent/DE69018215D1/en

1995-09-14Application grantedgrantedCritical

1995-09-14Publication of DE69018215T2publicationCriticalpatent/DE69018215T2/en

2010-12-13Anticipated expirationlegal-statusCritical

StatusExpired - Fee Relatedlegal-statusCriticalCurrent

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/16—Preparation of optical isomers
- C07C231/18—Preparation of optical isomers by stereospecific synthesis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/16—Preparation of optical isomers
- C07C231/20—Preparation of optical isomers by separation of optical isomers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Analytical Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Epoxy Compounds (AREA)

DE69018215T1989-12-271990-12-12 Process for the production of optically active atenolol and intermediate product thereof.Expired - Fee RelatedDE69018215T2 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP1344447AJPH0674243B2 (en)	1989-12-27	1989-12-27	Optically active atenolol salt with high optical purity and process for producing atenolol

Publications (2)

Publication Number	Publication Date
DE69018215D1true DE69018215D1 (en)	1995-05-04
DE69018215T2 DE69018215T2 (en)	1995-09-14

Family

ID=18369339

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE69026281TExpired - Fee RelatedDE69026281T2 (en)	1989-12-27	1990-12-12	Process for the purification and isolation of optically active atenolol with high yield
DE69018215TExpired - Fee RelatedDE69018215T2 (en)	1989-12-27	1990-12-12	Process for the production of optically active atenolol and intermediate product thereof.

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DE69026281TExpired - Fee RelatedDE69026281T2 (en)	1989-12-27	1990-12-12	Process for the purification and isolation of optically active atenolol with high yield

Country Status (7)

Country	Link
US (1)	US5130482A (en)
EP (2)	EP0605384B1 (en)
JP (1)	JPH0674243B2 (en)
KR (1)	KR960001436B1 (en)
CA (1)	CA2032098C (en)
DE (2)	DE69026281T2 (en)
ES (2)	ES2072960T3 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5290958A (en)*	1993-03-18	1994-03-01	Industrial Technology Research Institute	Phase transfer catalytic process for preparing intermediates of atenolol, propranolol, and their derivatives
ES2065278B1 (en)*	1993-06-24	1995-09-01	Medichem Sa	LEVOBUNOLOL ENANTIOSELECTIVE PROCEDURE FOR OBTAINING.
US5476964A (en)*	1994-11-21	1995-12-19	Uop	Continuous racemization of benzylic alcohols, ethers, and esters by solid acid catalyst
WO2001040173A1 (en)*	1999-11-29	2001-06-07	Nippon Shinyaku Co., Ltd.	Method of separation and purification
JP2002080435A (en)	2000-06-26	2002-03-19	Kanegafuchi Chem Ind Co Ltd	Method for producing 3-amino-2-hydroxypropionic acid derivative
WO2004002974A1 (en)*	2002-05-30	2004-01-08	Daiso Co., Ltd.	Process for producing glycidyl ether
WO2006046252A2 (en)*	2004-10-26	2006-05-04	Ipca Laboratories Limited	Novel diasteriomeric salts of atenolol and their use in the production of optically active atenolol
WO2006137773A1 (en)*	2005-06-20	2006-12-28	Astrazeneca Ab	Process for the isolation of 4-(oxiranylmethoxy)-benzonitriles
JP5225574B2 (en)*	2006-11-09	2013-07-03	エムキュアファーマシューティカルズリミテッド	Improved process for the preparation of beta-blocker compounds
KR101330783B1 (en)*	2006-11-27	2013-11-18	엠큐어 파마슈티컬즈 리미티드	An improved preparation of a beta blocker compound
KR100900573B1 (en)*	2007-08-23	2009-06-02	케이피엑스 라이프사이언스 주식회사	(S)-Method of producing atenolol
CN102241603A (en)*	2010-05-10	2011-11-16	中国科学院理化技术研究所	Asymmetric synthesis method of R-or S-acebutolol
CN102603557B (en)*	2011-12-29	2014-07-02	蚌埠丰原医药科技发展有限公司	Preparation method of atenolol
CN103739512A (en)*	2014-01-24	2014-04-23	南京工业大学	Method for preparing (S) -atenolol
CN118638024A (en)*	2024-03-18	2024-09-13	山东益康药业股份有限公司	A kind of preparation method of atenolol raw material medicine

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1285038A (en)*	1969-02-21	1972-08-09	Ici Ltd	Alkanolamine derivatives
US3934032A (en)*	1969-02-21	1976-01-20	Imperial Chemical Industries Limited	Alkanolamine derivatives for treating hypertension
US3836671A (en)*	1969-02-21	1974-09-17	Ici Ltd	Alkanolamine derivatives for producing beta-adrenergic blockade
GB1458393A (en)*	1973-10-09	1976-12-15	Ici Ltd	Optically-active 1-aryloxypropan-2ol derivatives
GB1458392A (en)*	1973-11-09	1976-12-15	Ici Ltd	Optically-active 1-aryloxy-2,3-epoxypropane derivatives
JPS5714586A (en)*	1980-07-01	1982-01-25	Teikoku Hormone Mfg Co Ltd	Substituted benzaldehyde
DE3147150C2 (en)*	1981-11-27	1984-01-05	Bayer Ag, 5090 Leverkusen	Process for the production of epoxypropane derivatives
GB2120659B (en)*	1982-04-28	1985-12-04	Sumitomo Chemical Co	Process for producing glycidyl ethers of monohydric polyhydric phenols
DE3330005A1 (en)*	1983-08-19	1985-02-28	Wolfgang Dr. Graz Lindner	TONIC ACID MONOESTERS OF OPTICALLY ACTIVE ALKANOLAMINES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE
DE3500761A1 (en)*	1985-01-11	1986-09-04	SOUR "PODRAVKA" OOUR "BELUPO 2", Proizvodnja kozmeti&ccaron;kih preparata i lijekova, Koprivnica	Process for the production of atenolol and its derivatives
AU589594B2 (en)*	1985-02-13	1989-10-19	Gist-Brocades N.V.	Process for the preparation of arylglycidyl ethers and 3-substituted 1-alkylamino-2-propanlos
JPS63270651A (en)*	1987-04-28	1988-11-08	Toyo Pharma- Kk	Production of 1-(4-carbamoylmethyl)phenoxy-3-isopropylamino-2-propanol or salt thereof
ES2050425T3 (en)*	1988-12-26	1994-05-16	Kowa Co	PRODUCTION OF A GLICIDILIC ETHER.

1989
- 1989-12-27JPJP1344447Apatent/JPH0674243B2/ennot_activeExpired - Fee Related
1990
- 1990-12-07USUS07/624,302patent/US5130482A/ennot_activeExpired - Fee Related
- 1990-12-12EPEP94100873Apatent/EP0605384B1/ennot_activeExpired - Lifetime
- 1990-12-12ESES90123904Tpatent/ES2072960T3/ennot_activeExpired - Lifetime
- 1990-12-12CACA002032098Apatent/CA2032098C/ennot_activeExpired - Fee Related
- 1990-12-12ESES94100873Tpatent/ES2088299T3/ennot_activeExpired - Lifetime
- 1990-12-12DEDE69026281Tpatent/DE69026281T2/ennot_activeExpired - Fee Related
- 1990-12-12EPEP90123904Apatent/EP0435068B1/ennot_activeExpired - Lifetime
- 1990-12-12DEDE69018215Tpatent/DE69018215T2/ennot_activeExpired - Fee Related
- 1990-12-27KRKR1019900021996Apatent/KR960001436B1/ennot_activeExpired - Fee Related

Also Published As

Publication number	Publication date
EP0605384A1 (en)	1994-07-06
DE69026281D1 (en)	1996-05-02
KR960001436B1 (en)	1996-01-27
EP0605384B1 (en)	1996-03-27
EP0435068A3 (en)	1991-11-13
CA2032098C (en)	1998-04-14
KR910011765A (en)	1991-08-07
EP0435068B1 (en)	1995-03-29
DE69026281T2 (en)	1996-10-02
JPH03200753A (en)	1991-09-02
ES2072960T3 (en)	1995-08-01
JPH0674243B2 (en)	1994-09-21
DE69018215T2 (en)	1995-09-14
CA2032098A1 (en)	1991-06-28
US5130482A (en)	1992-07-14
EP0435068A2 (en)	1991-07-03
ES2088299T3 (en)	1996-08-01

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Legal Events

Date	Code	Title	Description
1996-04-25	8364	No opposition during term of opposition
2000-02-10	8339	Ceased/non-payment of the annual fee

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