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DE3382837D1 - Production of functional human urokinase proteins - Google Patents

Production of functional human urokinase proteins

Info

Publication number
DE3382837D1
DE3382837D1DE3382837TDE3382837TDE3382837D1DE 3382837 D1DE3382837 D1DE 3382837D1DE 3382837 TDE3382837 TDE 3382837TDE 3382837 TDE3382837 TDE 3382837TDE 3382837 D1DE3382837 D1DE 3382837D1
Authority
DE
Germany
Prior art keywords
production
functional human
human urokinase
proteins
urokinase proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3382837T
Other languages
German (de)
Other versions
DE3382837T2 (en
Inventor
Herbert Louis Heyneker
William Evans Holmes
Gordon Alan Vehar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech IncfiledCriticalGenentech Inc
Application grantedgrantedCritical
Publication of DE3382837D1publicationCriticalpatent/DE3382837D1/en
Anticipated expirationlegal-statusCritical
Publication of DE3382837T2publicationCriticalpatent/DE3382837T2/en
Expired - Lifetimelegal-statusCriticalCurrent

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Classifications

Landscapes

Abstract

Novel derivatives of the human protein urokinase are disclosed together with methods of making them using recombinant DNA technology.
DE3382837T1982-04-151983-04-14 Production of functional human urokinase proteinsExpired - LifetimeDE3382837T2 (en)

Applications Claiming Priority (2)

Application NumberPriority DateFiling DateTitle
US36877382A1982-04-151982-04-15
US47493083A1983-03-141983-03-14

Publications (2)

Publication NumberPublication Date
DE3382837D1true DE3382837D1 (en)2003-03-13
DE3382837T2 DE3382837T2 (en)2004-01-15

Family

ID=27004326

Family Applications (2)

Application NumberTitlePriority DateFiling Date
DE3382760TExpired - LifetimeDE3382760T2 (en)1982-04-151983-04-14 Production of functional human urokinase polypeptides.
DE3382837TExpired - LifetimeDE3382837T2 (en)1982-04-151983-04-14 Production of functional human urokinase proteins

Family Applications Before (1)

Application NumberTitlePriority DateFiling Date
DE3382760TExpired - LifetimeDE3382760T2 (en)1982-04-151983-04-14 Production of functional human urokinase polypeptides.

Country Status (20)

CountryLink
EP (2)EP0092182B1 (en)
JP (3)JPH0655145B2 (en)
AT (2)ATE112802T1 (en)
AU (1)AU573523B2 (en)
BR (1)BR8301918A (en)
CA (1)CA1341301C (en)
DE (2)DE3382760T2 (en)
DK (1)DK173910B1 (en)
ES (3)ES8500325A1 (en)
FI (1)FI88932C (en)
GR (1)GR78180B (en)
HK (1)HK38297A (en)
IE (1)IE64536B1 (en)
IL (2)IL68366A (en)
MY (1)MY102472A (en)
NO (1)NO831317L (en)
NZ (1)NZ203869A (en)
PH (4)PH24783A (en)
PT (1)PT76546B (en)
YU (1)YU45128B (en)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US4370417A (en)*1980-04-031983-01-25Abbott LaboratoriesRecombinant deoxyribonucleic acid which codes for plasminogen activator
AU587960B2 (en)*1983-06-241989-09-07Genentech Inc.Procaryotic carbonyl hydrolases
IE81141B1 (en)*1983-06-242000-04-05Genencor IntProcaryotic carbonyl hydrolases
EP0139447B1 (en)*1983-09-131992-12-30The Green Cross CorporationA process for preparing urokinase zymogen
DE3585097D1 (en)*1984-02-271992-02-20Green Cross Corp PRODUCTION OF HUMAN UROKINASE.
JPS61177987A (en)*1985-01-311986-08-09Green Cross Corp:The Method for producing human urokinase
JPS60180591A (en)*1984-02-271985-09-14Green Cross Corp:TheDna sequence, plasmid and host of human urokinase
DE3680838D1 (en)*1985-01-251991-09-19Sagami Chem Res STABILIZED HUMAN PROUROKINASE.
JPS61181377A (en)*1985-01-251986-08-14Sagami Chem Res Center human urokinase gene
US5219569A (en)*1985-04-221993-06-15Genentech, Inc.Protease resistant urokinase
US4997766A (en)*1986-07-111991-03-05American Home Products CorporationPoly-kringle plasminogen activator
US4916071A (en)1985-08-141990-04-10American Home Products CorporationPoly-kringle plasminogen activator
JPS62149625A (en)*1985-12-251987-07-03Green Cross Corp:The Method for producing physiologically active substances
DE3613401A1 (en)*1986-04-211987-12-17Boehringer Mannheim Gmbh METHOD FOR PRODUCING PLASMINOGEN ACTIVATORS IN PROKARYONTS
NL8601240A (en)*1986-05-151987-12-01Leuven Res & Dev Vzw PLASMINOGEN ACTIVATOR AND THROMBOLYTIC MEDICINAL PRODUCT.
GB8623823D0 (en)*1986-10-031986-11-05Sandoz LtdTherapeutic lysis of fibrin blood clots
JPS63105675A (en)*1986-10-231988-05-10Green Cross Corp:TheProduction of human urokinase
ZA879286B (en)1986-12-161988-10-26Smith Kline RitNew plasminogen activators
GB2200640B (en)*1987-01-301991-07-10American Home ProdDes-epidermal growth factor plasminogen activators
MY103358A (en)*1987-04-151993-06-30Novartis AgProcess for the production of protiens.
US5188829A (en)*1987-08-191993-02-23Sagami Chemical Research CenterRapidly acting prourokinase
DK555488A (en)*1987-10-021989-06-14Zymogenetics Inc secretion
AU2354588A (en)*1987-10-091989-04-20Collaborative Research Inc.Modified low molecular weight plasminogen activator and method of preparation
US4999194A (en)*1988-01-141991-03-12Collaborative Research, Inc.Two-chain urokinase plasminogen activators for treatment of thrombotic disease
US4920051A (en)*1988-02-031990-04-24Damon Biotech, Inc.Recovery of urokinase compounds
IE901849A1 (en)*1989-07-191991-06-19Gruenenthal GmbhPlasmids, their preparation and their use in the manufacture¹of a plasminogen activator
AU6470590A (en)1989-10-231991-04-26Smithkline Beecham CorporationCyclic anti-aggregatory peptides
ATE212672T1 (en)*1989-10-242002-02-15Chiron Corp SYSTEM FOR RELEASING INFECTIOUS PROTEINS
DE4101736A1 (en)*1991-01-221992-07-23Gruenenthal Gmbh NEW PLASMINOGENACTIVATORS USEFUL POLYPEPTIDES, DAFUER CODING PLASMIDS AND METHOD FOR THE PRODUCTION THEREOF AND THEIR USE
US5888814A (en)*1994-06-061999-03-30Chiron CorporationRecombinant host cells encoding TNF proteins
ATE290600T1 (en)*1998-06-262005-03-15Croptech Dev Corp PRODUCTION OF UROKINASE IN PLANT EXPRESSION SYSTEMS
AU2001269803A1 (en)2000-06-202002-01-02The Trustees Of The University Of PennsylvaniaCompositions and methods for modulating muscle cell and tissue contractility
US20030040095A1 (en)*2001-03-162003-02-27Achille AriniMethod for the production of pharmaceutically active recombinant proteins
CA2626356C (en)2005-10-212017-08-22Catalyst Biosciences, Inc.Modified proteases that inhibit complement activation
CA2656531C (en)2006-07-052012-12-11Catalyst Biosciences, Inc.Protease screening methods and proteases identified thereby

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
WO1981001417A1 (en)*1979-11-131981-05-28S HusainIsolation of plasminogen activators useful as therapeutic and diagnostic agents
US4321363A (en)*1980-02-211982-03-23Nippon Soda Company LimitedAdsorbent for urokinase containing agarose
US4370417A (en)*1980-04-031983-01-25Abbott LaboratoriesRecombinant deoxyribonucleic acid which codes for plasminogen activator
US4506013A (en)*1980-10-031985-03-19Eli Lilly And CompanyStabilizing and selecting recombinant DNA host cells
GR80966B (en)*1983-11-211985-03-15Ciba Geigy AgSynthesis of fibrinolytic agents by yeast

Also Published As

Publication numberPublication date
JPH0824579B2 (en)1996-03-13
FI831228L (en)1983-10-16
JP2584192B2 (en)1997-02-19
IE64536B1 (en)1995-08-09
PT76546B (en)1986-03-20
AU1352483A (en)1983-10-20
IL68366A0 (en)1983-07-31
NO831317L (en)1983-10-17
PH25312A (en)1991-04-30
EP0620279A1 (en)1994-10-19
FI831228A0 (en)1983-04-12
JPH0530970A (en)1993-02-09
PH25120A (en)1991-02-19
JPH0655145B2 (en)1994-07-27
ES8602121A1 (en)1985-12-01
DE3382837T2 (en)2004-01-15
IL83236A0 (en)1987-12-31
HK38297A (en)1997-04-04
FI88932C (en)1993-07-26
ATE112802T1 (en)1994-10-15
JPH07186A (en)1995-01-06
MY102472A (en)1992-06-30
GR78180B (en)1984-09-26
DK173910B1 (en)2002-02-11
NZ203869A (en)1987-04-30
CA1341301C (en)2001-10-09
PH24783A (en)1990-10-30
DE3382760T2 (en)1995-03-02
YU86883A (en)1988-10-31
AU573523B2 (en)1988-06-16
ES8506087A1 (en)1985-07-01
JPS5951300A (en)1984-03-24
DK163683A (en)1983-11-28
PH22461A (en)1988-09-12
EP0092182B1 (en)1994-10-12
EP0092182A2 (en)1983-10-26
YU45128B (en)1992-03-10
ES521418A0 (en)1984-11-01
DK163683D0 (en)1983-04-14
ES8500325A1 (en)1984-11-01
EP0092182A3 (en)1984-07-18
ATE232237T1 (en)2003-02-15
ES533925A0 (en)1985-12-01
BR8301918A (en)1983-12-20
FI88932B (en)1993-04-15
EP0620279B1 (en)2003-02-05
PT76546A (en)1983-05-01
DE3382760D1 (en)1994-11-17
ES533924A0 (en)1985-07-01
IE830850L (en)1983-10-15
IL68366A (en)1990-08-31
IE950235L (en)1983-10-15

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