Verfahren zur Herstellung von zur Desensibilisierung von Allergosengeeigneten Stoffen. Process for the preparation of for the desensitization of allergiessuitable substances.
Es ist bekannt, daß man Allergosen, dh. Personen, welche eine Uberempfindlichkeitgegen die verschiedensten Stoffe der Umwelt besitzen, durch Desensibilisieren, d.h. durch langdauernde Verabreichung von Rein-Antigenen immunisieren kann. In manchenFallen ist diese Immunisierung erfolgreich, in anderen jedoch erfolglos. In letzterenFällen liegt die Ursache in der schwachen Aktivität der angewandten Antigene. It is known that allergies, ie. People who have hypersensitivitypossess against the most diverse substances in the environment, by desensitizing, d.H. can immunize by long-term administration of pure antigens. In someThis immunization is successful in traps, but unsuccessful in others. In the latterIn some cases, the cause lies in the weak activity of the antigens used.
Es hat sich nun überraschenderweise gezeigt, daß man Antigene wirksammachen oder, sofern sie zu schwach wirksam waren, dadurch aktivieren kann, daß manden Antigen-Lösungen Metallhydroxyde zusetzt. It has now surprisingly been shown that antigens are effectivemake or, if they were too weakly effective, activate them bymetal hydroxides added to the antigen solutions.
Beispiels Meerschweinchen, welche mit 0,5 mg Bienentrockengift +Freund'schem Adjuvans subcutan sensibilisiert worden sind, wurden nach drei Wochenmit o, 18 mg Bienentrockengift intravenös reinjiziert. Die Tierekamen im anaphylaktischen Schock ad exitum. For example guinea pigs, which with 0.5 mg dry bee venom +Freund's adjuvant were sensitized subcutaneously after three weekswith 0.18 mg of dry bee venomreinjected intravenously. The animalsdied in anaphylactic shock.
Verwendet man bei einem Wiederholungsversuch ein Reaktionsgemischaus dem reinen Bienentrockengift und o, 2 com einer ioVoigen Aluminiumhydroxydlösungund behandelt man die Tiere täglich bis zum Tage der Reinjektion (drei Wochen) subcutanmit diesem Stoff, so bleiben die Tiere am Leben, und es werden keine Schock- odersonstigen Krankheitserscheinungen beobachtet. If a reaction mixture is used in a repeat attemptfrom the pure dehydrated bee poison and 0.2 com of an ioVoigen aluminum hydroxide solutionand the animals are treated subcutaneously daily up to the day of reinjection (three weeks)With this substance, the animals stay alive and there are no shock orother symptoms observed.
Anstelle von Bienengift können auch andere Antigene, z.B. andereInsektengifte, Blütenpollen, sogenannte Hausantigene, bakterielle oder alimentäreAntigene verwendet werden. Instead of bee venom, other antigens, e.g. otherInsecticides, bee pollen, so-called house antigens, bacterial or alimentaryAntigens are used.
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEM0050492 | 1961-10-06 |
| Publication Number | Publication Date |
|---|---|
| DE1492010A1true DE1492010A1 (en) | 1969-07-17 |
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19611492010PendingDE1492010A1 (en) | 1961-10-06 | 1961-10-06 | Process for the production of substances suitable for desensitizing allergies |
| Country | Link |
|---|---|
| DE (1) | DE1492010A1 (en) |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0232717A3 (en)* | 1986-01-10 | 1989-02-15 | Shiosaka Sadao | Antibody specific to low-molecular weight substance and method of producing the same by using colloidal metal particles as carrier |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0232717A3 (en)* | 1986-01-10 | 1989-02-15 | Shiosaka Sadao | Antibody specific to low-molecular weight substance and method of producing the same by using colloidal metal particles as carrier |
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|---|---|---|
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