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CR10910A - INDAZOLS REPLACED WITH AMIDA AS POLY INHIBITORS (ADP-RIBOSA) POLYMERASE (PARP) - Google Patents

INDAZOLS REPLACED WITH AMIDA AS POLY INHIBITORS (ADP-RIBOSA) POLYMERASE (PARP)

Info

Publication number
CR10910A
CR10910ACR10910ACR10910ACR10910ACR 10910 ACR10910 ACR 10910ACR 10910 ACR10910 ACR 10910ACR 10910 ACR10910 ACR 10910ACR 10910 ACR10910 ACR 10910A
Authority
CR
Costa Rica
Prior art keywords
parp
adp
polymerase
inhibitors
poly
Prior art date
Application number
CR10910A
Other languages
Spanish (es)
Inventor
Philip Jones
Ontoria Jesus Maria Ontoria
Rita Scarpelli
Carsten Schultz-Fademrecht
Original Assignee
Angeletti P Ist Richerche Bio
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filedlitigationCriticalhttps://patents.darts-ip.com/?family=37809722&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR10910(A)"Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Angeletti P Ist Richerche BiofiledCriticalAngeletti P Ist Richerche Bio
Publication of CR10910ApublicationCriticalpatent/CR10910A/en

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Abstract

The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts, stereoisomers or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory discuses, reperfusion injuries, ischemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes, neurodegenerative diseases, retroviral infection, retinal damage or skin senescence and UV-induced skin damage, and as chemo and/or radiosensitizers for cancer treatment.
CR10910A2007-01-102009-07-02 INDAZOLS REPLACED WITH AMIDA AS POLY INHIBITORS (ADP-RIBOSA) POLYMERASE (PARP)CR10910A (en)

Applications Claiming Priority (1)

Application NumberPriority DateFiling DateTitle
GBGB0700432.8AGB0700432D0 (en)2007-01-102007-01-10Therapeutic compounds

Publications (1)

Publication NumberPublication Date
CR10910Atrue CR10910A (en)2010-01-19

Family

ID=37809722

Family Applications (1)

Application NumberTitlePriority DateFiling Date
CR10910ACR10910A (en)2007-01-102009-07-02 INDAZOLS REPLACED WITH AMIDA AS POLY INHIBITORS (ADP-RIBOSA) POLYMERASE (PARP)

Country Status (21)

CountryLink
CN (1)CN101578279B (en)
AT (1)ATE502933T1 (en)
CR (1)CR10910A (en)
DE (1)DE602008005711D1 (en)
DK (2)DK2336120T3 (en)
ES (3)ES2362214T3 (en)
GB (1)GB0700432D0 (en)
HN (1)HN2009001260A (en)
HU (1)HUE044513T2 (en)
LT (1)LT2805945T (en)
LU (1)LUC00072I2 (en)
ME (1)ME03481B (en)
MY (1)MY147789A (en)
NI (1)NI200900135A (en)
NZ (1)NZ578256A (en)
PE (1)PE20081558A1 (en)
PT (3)PT2805945T (en)
SI (2)SI2336120T1 (en)
TW (1)TWI528961B (en)
UA (1)UA97658C2 (en)
ZA (1)ZA200903898B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
CN106496187A (en)*2016-09-142017-03-15陕西科技大学A kind of synthetic method for preparing PARP inhibitor Niraparib
CN106432188A (en)*2016-09-172017-02-22青岛辰达生物科技有限公司Preparation method of anti-cancer drug 2-[4-((3S)-3-Piperidinyl) phenyl]-2H-Indazole-7-Formamide
CN106432187A (en)*2016-09-172017-02-22青岛云天生物技术有限公司Chiral resolution method of 2-[4-(-3-piperidyl)phenyl]-2H-indazole-7-formamide
CN106632244A (en)*2016-09-302017-05-10陕西科技大学A novel synthetic method for preparing an anticancer medicine Niraparib
CN106467513A (en)*2016-09-302017-03-01陕西科技大学A kind of synthetic method preparing Niraparib
CN108201537A (en)*2016-12-162018-06-26苏州苏融生物医药有限公司A kind of Ni Lapani sustained and controlled release medicaments composition and application thereof
WO2018183349A1 (en)*2017-03-272018-10-04Tesaro, Inc.Niraparib formulations
CN109081828B (en)*2017-06-142021-03-26上海时莱生物技术有限公司Poly (ADP-ribose) polymerase inhibitor, preparation method and application
CN111278433A (en)2017-09-262020-06-12特沙诺有限公司Nilaparib formulations
CN108084157A (en)*2018-02-122018-05-29安庆奇创药业有限公司A kind of synthetic method of Ni Lapani
CN108203404A (en)*2018-03-022018-06-26上海博邦医药科技有限公司(R) synthetic method of -3- Phenylpiperidines or/and the chiral intermediate of (S) -3- Phenylpiperidines and Ni Lapani
US20240016775A1 (en)2020-02-242024-01-18Fukang (Shanghai) Health Technology Co., LtdAnti-coronavirus application of poly adp ribose polymerase inhibitor
CN115611860B (en)*2021-07-132024-06-11上海博璞诺科技发展有限公司Method for synthesizing nilaparib

Also Published As

Publication numberPublication date
CN101578279B (en)2013-07-17
MY147789A (en)2013-01-31
DK2109608T3 (en)2011-07-11
SI2109608T1 (en)2011-07-29
LT2805945T (en)2019-06-25
TW200836731A (en)2008-09-16
ATE502933T1 (en)2011-04-15
ES2509115T3 (en)2014-10-17
HN2009001260A (en)2012-03-26
DK2336120T3 (en)2014-10-06
DE602008005711D1 (en)2011-05-05
ME03481B (en)2020-01-20
UA97658C2 (en)2012-03-12
HUE044513T2 (en)2019-10-28
ES2362214T3 (en)2011-06-29
PE20081558A1 (en)2008-10-30
PT2336120E (en)2014-10-01
GB0700432D0 (en)2007-02-21
NZ578256A (en)2011-12-22
CN101578279A (en)2009-11-11
ZA200903898B (en)2010-04-28
PT2109608E (en)2011-05-30
NI200900135A (en)2010-08-30
TWI528961B (en)2016-04-11
PT2805945T (en)2019-06-06
SI2336120T1 (en)2014-10-30
LUC00072I2 (en)2018-07-04
ES2728199T3 (en)2019-10-22

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