CN2414777Y - Transcutaneous medicine osmosis instrument - Google Patents

Abstract

The utility model discloses a transcutaneous medicine osmosing instrument. The core part of the utility model is an application disk which is composed of a top surface, an inner annular side wall and an outer annular side wall, and an annular space between the two walls is communicated with a negative pressure source. When the transcutaneous medicine osmosis instrument is used for treatment, skin is tightly sucked, a concave medicine giving space in the center is completely sealed and is rapidly heated up under the heating of an electric heating element in the top surface, the volatile ingredients of medicine of a medicine pad arranged in the medicine giving space are released, the pressure of the medicine giving space is raised to provide effective power for the transcutaneous osmosis of the medicine, therefore the utility model can obviously enhance the transcutaneous medicine giving rate so as to make the medicine achieve required treating dose and raise a treating effect.

Description

Transdermal medicine permeating meter

This utility model relates to a kind of applying ointment or plaster to be made drug transdermal enter in the body on human body skin and plays the transdermal medicine permeating meter of therapeutical effect.

The method transdermal of medicine by percutaneous dosing enters the human lesion position or the acupuncture point plays a role, can avoid the oral drugs medicine that especially toxicity is big that gastrointestinal is injured, avoid the decomposition destruction of the first pass effect of liver to effective ingredient, side effect is little, is a kind of effective method of treatment disease.But the skin of human body has very careful structure, and medicine sees through skin and is subjected to sizable resistance, is difficult to make medicine to reach needed therapeutic dose.Below two kinds of means can strengthen medicine percutaneous rate, increase the transdermal infiltration capacity of medicine: the first is heated, the temperature of drug of topical application position skin of can raising on the one hand of heating, accelerate local blood circulation, increase the permeability of skin, for entering, the transdermal of medicine provides physiological environment, can promote the release of drug volatilization composition on the other hand, strengthen the activity of medicine, active big drug microparticles transdermal enters intravital probability just greatly in the medicine because have only; It two is the local spaces (administration space) at sealing plaster medicine place, creates high as far as possible transdermal administration power.

General plastering therapy, as plaster and paster, all be medicine to be sticked on the skin, but because its administration space is not a complete closed, volatile ingredient easily leak by similar cover layer of applying ointment or plaster dish, the concentration that the active component of medicine is difficult to remain valid, can not form pressure differential between administration space and skin, and because the general means of heating that do not adopt, the permeability of skin is not high, the transdermal infiltration capacity of medicine was very little when this made treatment, affected the treatment.

Various hot-dressing therapeutic instruments on the market, as therapeutic instrument by patent ZL 91107121.0 mades, and another patent ZL 96205283.3 disclosed therapeutic instruments of the applicant, its basic skills all is to adopt heating to add the hot application dish, under the dish of applying ointment or plaster, place the medicated cushion that is added with medicine, medicated cushion posts on skin, plays the effect of medication.Dish is that the mode that adopts rope band bondage or sandbag to overlay posts on skin though this method by having added the permeability of skin heat gain, is applied ointment or plaster, and the spatial closure of administration is still not tight, after the heating, the escape that scatters of drug volatilization active component, transdermal administration is short of power, and curative effect is not good enough.

Traditional cupping jar can form a tight-closed pressure field on the surface of skin.Patent ZL96218476.4 discloses a kind of vacuum tank medication scheme, rises on being adsorbed on skin in the vacuum tank of physiotherapy function, places a medicated cushion that is added with medicine, wishes to play the effect of medication.But this method, owing to do not heat, the permeability of skin is not high, and main is, and the administration space at medicated cushion place is a negative pressure field, and drug particle is difficult to reverse transdermal and enters human body and bring into play therapeutical effect.In addition,,, strengthen the transdermal infiltration capacity, should adopt large-area administration space as far as possible in order to improve therapeutic effect because the transdermal infiltration capacity of medicine is to be directly proportional with the contact area of skin with medicine.If adopt cupping jar or vacuum tank to come transdermal administration, just must adopt bigbore jar of type, but bigbore cupping jar, vacuum tank can only be adsorbed on the smooth part of health, and be difficult to be adsorbed on the uneven place or the cambered surface places such as neck, arm of health.

The purpose of this utility model provides a kind of transdermal medicine permeating meter, can make the administration space tight-closed, and when heating, the administration space pressure is raise, become a malleation field of force,, improve the percutaneous rate of medicine for medicine provides transdermal administration power, increase the transdermal infiltration capacity of medicine, thereby strengthen therapeutic effect.

Transdermal medicine permeating meter of the present utility model comprises the applying ointment or plaster dish and place medicated cushion under the dish of applying ointment or plaster that posts when using on the body local skin, and the dish of applying ointment or plaster is by heating heating placed on it and that join with power supply.The described dish of applying ointment or plaster is made of an end face and twice annular sidewall, is outer wall together wherein, is inwall together, and two walls are spaced a distance, and its upper end is all affixed with described end face, abuts on the skin of treatment place during the treatment of lower end.Described outer wall, inwall and end face have surrounded an annular space, constitute to have a passway on this spatial wall at least and communicate with a negative pressure source.Surrounded a concave shaped space by described inwall and end face, this space is the administration space, and described medicated cushion promptly places in this space.

The described dish of applying ointment or plaster is flat, is made by flexible material, and the height of described inside and outside wall is advisable with 2 to 8 millimeters.

Described passway can be opened on outer wall, also can open on inwall, but preferably open on end face or open angle of cut place at end face and inside and outside wall, the negative pressure in the time of can avoiding the position of or cutis laxa more at the fat of applying ointment or plaster like this in the annular space does not also reach desired numerical value and skin that the passway is just picked up is blocked.If open on end face the passway, preferably there are groove or duct that the angle of cut of passway and end face and inside and outside wall is linked up, then its probability that is blocked is just littler.

Adopt transdermal medicine permeating meter of the present utility model, during use, its dish of applying ointment or plaster is applied ointment or plaster on the skin at human lesion position or place, acupuncture point, negative pressure source is taken the part air in the annular space away, form annular negative pressure cavity, suck skin, intermediary like this spill administration space is able to complete closed.Under the heating of heating, the temperature in the administration space of sealing raises, and the drug volatilization composition discharges in a large number, and active component increases, and the space internal pressure increases, and forms the malleation field of force of a sealing, helps drug transdermal and enters in the body.

The flat that adopts flexible material the to manufacture dish of applying ointment or plaster has whole and partial deformability, can apply ointment or plaster at the different parts of health, comprises cambered surface places such as neck, arm, and this provides possible for adopting large-sized medicated cushion to increase the drug transdermal infiltration capacity.

Transdermal medicine permeating meter of the present utility model, owing to have unique sealing pressurizing mechanism of heating, sealing and have the injection tube of the administration space of pressure as syringe, medicine can obtain the propulsive power of transdermal, numerous ducts of the degree of opening of having improved under the effect of temperature are just as the syringe needle of pricking in the skin on the skin, thereby transdermal medicine permeating meter of the present utility model is compared with general percutaneous dosing method, can improve the percutaneous rate of medicine widely, make medicine reach needed therapeutic dose at short notice.This point isolated skin permeability test of chamber has by experiment obtained confirmation.In addition,, use this instrument and cooperate the invigorating blood circulation of Chinese medicine, the kidney invigorating class medicine, hyperosteogeny, lumbago and skelalgia, cervical spondylosis, rheumatic and rheumatoid, the frequent micturition chronic diseases patient that suffers from a deficiency of the kidney has all been obtained significant curative effect through the clinical trial of 230 many cases.

Below in conjunction with accompanying drawing this utility model embodiment is described in further detail.

Fig. 1 is the cross-sectional schematic of an embodiment of this utility model transdermal medicine permeating meter.

Fig. 2 is the upward view of applying ointment or plaster among Fig. 1 and coiling.

Fig. 3 is the cutaway view of applying ointment or plaster and coiling of another embodiment of this utility model transdermal medicine permeating meter.

Fig. 4 is the cutaway view of applying ointment or plaster and coiling of the another embodiment of this utility model transdermal medicine permeating meter.

By Fig. 1, Fig. 2 as can be seen, in the end face 1 of the dish of applying ointment orplaster heating 4 is housed, connects power supply bylead 41,annular sidewall 2,3 upper ends and end face 1 join, and the lower end abuts on the skin 9 at human body therapy place.The annular space 6 that forms betweenouter wall 2 and theinwall 3 communicates with negative pressure source by passway 5.The concave shaped space 7 that forms betweeninwall 3 and the end face 1 is administration space, built-in medicated cushion 8.The dish of applying ointment or plaster is flat, is made by flexible material such as rubber or latex.The height ofsidewall 2,3 is 2 to 8 millimeters, and 2 millimeters of the upper limits of this size are to guarantee that annular space 6 can be contained in the skin 9 that is lifted under the suction function and make the dish of applying ointment or plaster suck minimum dimension on skin; And the lower limit of this size is for 8 millimeters to make the dish of applying ointment or plaster have the full-size of good whole and local deformability, less than this size the dish of applying ointment or plaster during uneven or cambered surface position, also can be out of shape with the fluctuating of health at the health of applying ointment or plaster, and it is tight to fit.In addition, the height of sidewall also can make the heat ofheating 4 be transmitted to as soon as possible on the skin below 8 millimeters, improves the permeability of skin during treatment as early as possible, shortens treatment time.In this embodiment, end face 1 is a plane, andpassway 5 has only one, is positioned on the end face 1 of annular space 6.Havestria 51 at end face 1 lower surface, the angle of cut of this striacommunication passage mouth 5 and end face 1 and inside and outside wall.Like this, when the position of the more or cutis laxa of fat of applying ointment or plaster, the skin thatpassway 5 is difficult for being lifted is blocked, and uses more reliable.Be understood that also have same effect if will open the duct that thestria 51 on end face 1 lower surface changes into open in end face 1.

In another embodiment that Fig. 3 provides, the end face 1 of the dish of applying ointment or plaster is a curved surface, the different parts of the health that is easier to like this to apply ointment or plaster, and the dish of applying ointment or plaster when applying ointment or plaster is difficult for perk; Passway 5 has two, lays respectively at the angle of cut place ofouter wall 2 and inwall 3 and end face 1.

The embodiment that Fig. 4 provides is the modification of a last embodiment, and twopasswaies 5 still are positioned at the angle of cut place ofouter wall 2 and inwall 3 and end face 1, and different is that twopasswaies 5 of a last embodiment are independently, the easy demoulding when mold pressing is produced; And twopasswaies 5 among this embodiment merge into a place after passing end face 1, join with negative pressure source again, and are easy to use.

Claims (8)

1. transdermal medicine permeating meter, comprise posting when using and coil and place the medicated cushion (8) of applying ointment or plaster under coiling applying ointment or plaster on the body local skin, apply ointment or plaster dish by heating (4) heating placed on it and that join by lead 41 with power supply, it is characterized in that: the described dish of applying ointment or plaster is by an end face (1) and twice annular sidewall (2,3) constitute, be outer wall (2) together wherein, be inwall (3) together, two walls are spaced a distance, its upper end is all affixed with described end face (1), the lower end abuts on the skin (9) of treatment place when treating, described outer wall (2), inwall (3) and end face (1) have surrounded an annular space (6), constitute and have a passway (5) on this spatial wall at least and communicate with a negative pressure source, surrounded a concave shaped space (7) by described inwall (3) and end face (1), this space is administration space (7), and described medicated cushion (8) promptly places in this space.

2. transdermal medicine permeating meter according to claim 1 is characterized in that: the described dish of applying ointment or plaster is manufactured by flexible material, and is flat, and promptly the height of its sidewall (2,3) is less than the size of end face (1) surface direction.

3. transdermal medicine permeating meter according to claim 2 is characterized in that: the height of described outer wall (2), inwall (3) is 2 to 8 millimeters.

4. transdermal medicine permeating meter according to claim 1 and 2 is characterized in that: described passway (5) are positioned on the end face (1) of described annular space (6).

5. transdermal medicine permeating meter according to claim 4 is characterized in that: the angle of cut of end face (1) in described passway (5) and the described annular space (6) and outer wall (2), inwall (3) has stria or duct (51) to communicate.

6. transdermal medicine permeating meter according to claim 1 and 2 is characterized in that: described passway (5) have two, lay respectively at the angle of cut place of interior end face (1) of described annular space (6) and outer wall (2), inwall (3).

7. transdermal medicine permeating meter according to claim 1 and 2 is characterized in that: described end face (1) of applying ointment or plaster dish is one successive, can be plane or curved surface.

8. transdermal medicine permeating meter according to claim 2 is characterized in that: the described flexible material of manufacturing the dish of applying ointment or plaster is rubber or latex.

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