CN216703068U

Movatterモバイル変換

Info

Publication number: CN216703068U
Application number: CN202122506245.XU
Authority: CN
Inventors: 谢安; 罗芳; 毕海迪; 邹飏; 冯珍; 陈凯云; 方翔; 帅浪
Original assignee: Guangzhou Shengsheng Biotechnology Co ltd; First Affiliated Hospital of Nanchang University
Current assignee: Guangzhou Shengsheng Biotechnology Co ltd; First Affiliated Hospital of Nanchang University
Priority date: 2021-10-19
Filing date: 2021-10-19
Publication date: 2022-06-10
Anticipated expiration: 2031-10-19

Abstract

The utility model discloses a combined and detachable platelet-rich plasma preparation device, and relates to the technical field of medical equipment. Including the push-and-pull rod, first rubber buffer, piston liquid storage tube, piston centrifuging tube and second rubber buffer, the push-and-pull rod is inner to cooperate with first rubber buffer, and the push-and-pull rod assembly is in piston liquid storage tube, and piston liquid storage tube below is equipped with piston centrifuging tube, and piston centrifuging tube below opening part is disposable public luer end cap, and the intraductal second rubber buffer that is equipped with the unanimity of piston centrifuging tube internal diameter that matches of piston centrifuging tube, and the trompil in the middle of liquid transfer channel and the second rubber buffer of piston liquid storage tube bottom cup joints the cooperation mutually. The utility model has the advantages of rapid and convenient preparation of PRP, safety, stability, cost reduction, simple device and convenient and reliable use.

Description

Translated fromChinese

一种组合及可拆卸式富血小板血浆制备装置A combined and detachable platelet-rich plasma preparation device

技术领域technical field

本实用新型涉及的是医疗设备技术领域，具体涉及一种组合及可拆卸式富血小板血浆制备装置。The utility model relates to the technical field of medical equipment, in particular to a combined and detachable platelet-rich plasma preparation device.

背景技术Background technique

富血小板血浆(Platelet-richplasma，PRP)是新鲜全血经两次梯度离心后提取制得的富血小板的高浓度血浆，由于血液血浆，血小板，白细胞，红细胞成分沉降速率不同，经过2次离心后，血液成分大致分为三层，即血浆层、白膜层(富血小板血浆及白细胞层)及红细胞层。通过该原理，富血小板血浆就被分离出来。富血小板血浆被激活后，释放大量生长因子，具有迅速促进组织损伤愈合的作用。自富血小板血浆在口腔颌面外科应用以来，目前富血小板血浆(PRP)的应用已覆盖医疗美容、口腔颌面外科、运动医学、骨科、糖尿病难愈创面处理、康复医学科等多医疗学科中，涉及疾病从骨关节到软组织，并且适应症不断在被拓展。Platelet-rich plasma (PRP) is a high-concentration platelet-rich plasma extracted from fresh whole blood after twice gradient centrifugation. , The blood components are roughly divided into three layers, namely the plasma layer, the buffy coat (platelet-rich plasma and the white blood cell layer) and the red blood cell layer. By this principle, platelet-rich plasma is isolated. After platelet-rich plasma is activated, a large number of growth factors are released, which has the effect of rapidly promoting the healing of tissue damage. Since the application of platelet-rich plasma in oral and maxillofacial surgery, the application of platelet-rich plasma (PRP) has now covered medical beauty, oral and maxillofacial surgery, sports medicine, orthopedics, diabetic refractory wound treatment, rehabilitation medicine and other medical disciplines. , involving diseases ranging from bone and joint to soft tissue, and the indications are constantly being expanded.

当前，随着PRP技术的疗效被肯定，安全可靠,越来越多创新产品被开发用于制备富血小板血浆的制备中。但目前被广泛使用的PRP制备装置基本存在结构复杂、价格昂贵、操作(采集、分离、提取、注射等)过程繁琐、耗时漫长、所制得的富血小板血浆中血小板浓度不高、血浆品质不稳定且易被污染等缺陷，致使其在临床应用推广方面受到较大限制。At present, as the efficacy of PRP technology is confirmed, safe and reliable, more and more innovative products have been developed for the preparation of platelet-rich plasma. However, the currently widely used PRP preparation devices basically have complex structure, high price, cumbersome operation (collection, separation, extraction, injection, etc.) process, time-consuming, low platelet concentration in the obtained platelet-rich plasma, and poor plasma quality. Defects such as instability and easy contamination make it greatly limited in clinical application and promotion.

发明内容SUMMARY OF THE INVENTION

针对现有技术上存在的不足，本实用新型目的是在于提供一种组合及可拆卸式富血小板血浆制备装置，使得PRP的制备快捷方便，安全稳定，且降低了成本，装置简单，使用方便可靠。In view of the deficiencies in the prior art, the purpose of the present invention is to provide a combined and detachable platelet-rich plasma preparation device, which makes the preparation of PRP fast and convenient, safe and stable, and reduces the cost, the device is simple, and the use is convenient and reliable. .

为了实现上述目的，本实用新型是通过如下的技术方案来实现：一种组合及可拆卸式富血小板血浆制备装置，包括推拉杆、第一橡胶塞、活塞式储液管、活塞式离心管和第二橡胶塞，推拉杆内端与第一橡胶塞相配合，推拉杆装配在活塞式储液管内，活塞式储液管下方装配有活塞式离心管，活塞式离心管下方开口处为一次性公鲁尔堵头，活塞式离心管内匹配有与活塞式离心管内径一致的第二橡胶塞，活塞式储液管底部的移液通道与第二橡胶塞中间的开孔相套接配合。In order to achieve the above purpose, the present utility model is achieved through the following technical solutions: a combined and detachable platelet-rich plasma preparation device, comprising a push-pull rod, a first rubber stopper, a piston-type liquid storage tube, a piston-type centrifuge tube and The second rubber plug, the inner end of the push-pull rod is matched with the first rubber plug, the push-pull rod is assembled in the piston-type liquid storage tube, the piston-type centrifugal tube is assembled under the piston-type liquid storage tube, and the opening at the bottom of the piston-type centrifugal tube is disposable Male Luer plug, the piston type centrifuge tube is matched with a second rubber stopper with the same inner diameter as the piston type centrifuge tube, and the pipetting channel at the bottom of the piston type liquid storage tube is sleeved and matched with the opening in the middle of the second rubber stopper.

作为优选，所述的活塞式储液管为筒柱状结构，筒柱状结构内匹配有与活塞式储液管内径一致的第一橡胶塞，第一橡胶塞上的开孔上装配有推拉杆。活塞式储液管下方开口为第一母鲁尔接头，第一母鲁尔接头与移液通道相匹配，并与活塞式离心管相通。Preferably, the piston-type liquid storage tube has a cylindrical structure, a first rubber plug having the same inner diameter as the piston-type liquid storage tube is matched in the cylinder-column structure, and a push-pull rod is assembled on the opening of the first rubber plug. The opening below the piston-type liquid storage tube is a first female Luer connector, and the first female Luer connector is matched with the pipetting channel and communicated with the piston-type centrifuge tube.

作为优选，所述的移液通道固定在第二橡胶塞内，为一硬性通道，上端为第一公鲁尔接头，可与活塞式储液管的第一母鲁尔接头进行匹配，是血液在活塞式离心管及活塞式储液管内进行转移的通道。下端为移液通道旋转卡头。Preferably, the pipetting channel is fixed in the second rubber stopper, which is a rigid channel, and the upper end is a first male Luer connector, which can be matched with the first female Luer connector of the piston-type liquid storage tube. Channels for transfer in piston centrifuge tubes and piston reservoirs. The lower end is the rotating chuck of the pipetting channel.

作为优选，所述的活塞式离心管为一直径较活塞式储液管大的筒柱状装置，活塞式离心管下方开口为第二母鲁尔接头，第二母鲁尔接头与一次性公鲁尔堵头相匹配。Preferably, the piston-type centrifuge tube is a cylindrical device with a larger diameter than the piston-type liquid storage tube, and the opening below the piston-type centrifuge tube is a second female Luer connector, which is connected to a disposable male luer connector. er plugs to match.

作为优选，所述的推拉杆包括十字芯杆，十字芯杆上端装配有圆形薄片作为推拉板，十字芯杆下端设置有与第一橡胶塞相匹配的推拉杆旋卡头。Preferably, the push-pull rod includes a cross core rod, the upper end of the cross core rod is equipped with a circular sheet as a push-pull plate, and the lower end of the cross core rod is provided with a push-pull rod screw chuck matched with the first rubber plug.

作为优选，所述的活塞式储液管的开口通过旋卡头固定在第二橡胶塞内，穿过第二橡胶塞至活塞式离心管内，与第二橡胶塞下端相齐平。Preferably, the opening of the piston-type liquid storage tube is fixed in the second rubber stopper through a screwing head, passes through the second rubber stopper into the piston-type centrifuge tube, and is flush with the lower end of the second rubber stopper.

作为优选，所述的活塞式储液管直径较活塞式离心管短，使活塞式离心管保持密封的同时，活塞式储液管可作为活塞式离心管的推拉杆进行抽吸及注射。Preferably, the diameter of the piston type centrifuge tube is shorter than that of the piston type centrifuge tube, so that while the piston type centrifuge tube is kept sealed, the piston type fluid storage tube can be used as the push-pull rod of the piston type centrifuge tube for suction and injection.

作为优选，所述的活塞式离心管的下端为第二母鲁尔接头，可连接一次性公鲁尔堵头，并可连接三通管及无菌注射针，用于注射治疗及富血小板血浆凝胶的制备。Preferably, the lower end of the piston-type centrifuge tube is a second female luer connector, which can be connected to a disposable male luer plug, and can be connected to a tee tube and a sterile injection needle for injection therapy and platelet-rich plasma. Preparation of gels.

作为优选，所述的活塞式储液管及活塞式离心管管壁均设置有标记毫升数的标尺刻度，可用于明确抽液及转移的血液量。Preferably, the walls of the piston-type liquid storage tube and the piston-type centrifuge tube are provided with a scale marking the number of milliliters, which can be used to determine the amount of blood to be pumped and transferred.

本实用新型的活塞式储液管开口通道与第二橡胶塞接口连接方式采用鲁尔接口连接，开口为母鲁尔接头，而第二橡胶塞接头为公鲁尔接头。可通过旋转进行连接及断开。The opening channel of the piston type liquid storage tube and the interface of the second rubber plug of the utility model are connected by a Luer interface, the opening is a female Luer connector, and the second rubber plug connector is a male Luer connector. It can be connected and disconnected by turning.

本实用新型活塞式储液管在制备的合格的富血小板血浆后，通过逆时针旋转后，与活塞式离心管分离，可单独作为注射器进行富血小板血浆注射治疗使用。After preparing qualified platelet-rich plasma, the piston-type liquid storage tube of the utility model is separated from the piston-type centrifuge tube after being rotated counterclockwise, and can be used alone as a syringe for platelet-rich plasma injection therapy.

本实用新型的有益效果：采用模块组合式设计，所有制备腔室均可通过鲁尔接口进行拆卸，方便设备无菌存储及不同部位的穿刺注射治疗。在制备过程中，无需进行装置的拆装，制备富血小板血浆的所有过程均为完全密封状态，血液的离心及转移，均可保证完全无菌。所有制备过程均在同一装置内，减少了血液分离的徒手操作及血液转移过程，从而保证了所制得的产品的稳定与安全。该制备方法可简化了制备流程，成本低廉，能够为临床研究和治疗肌骨疾病提供一种高浓度、低成本的富血小板血浆的装置和方法。The beneficial effects of the utility model are as follows: the modular combined design is adopted, and all the preparation chambers can be disassembled through the Luer interface, which facilitates aseptic storage of the equipment and puncture injection treatment of different parts. In the preparation process, there is no need to disassemble and assemble the device, all the processes of preparing platelet-rich plasma are completely sealed, and the centrifugation and transfer of blood can ensure complete sterility. All preparation processes are in the same device, which reduces the manual operation of blood separation and the process of blood transfer, thereby ensuring the stability and safety of the prepared products. The preparation method can simplify the preparation process and has low cost, and can provide a high-concentration and low-cost platelet-rich plasma device and method for clinical research and treatment of musculoskeletal diseases.

附图说明Description of drawings

下面结合附图和具体实施方式来详细说明本实用新型；The present utility model will be described in detail below in conjunction with the accompanying drawings and specific embodiments;

图1是本实用新型的在包装存放状态及离心机内组装状态完整结构示意图；Fig. 1 is the complete structural representation of the present utility model in the packing storage state and the assembled state in the centrifuge;

图2是本实用新型中推拉杆与第一橡胶塞结合状态的结构示意图；Fig. 2 is the structural representation of the combined state of the push-pull rod and the first rubber plug in the present invention;

图3是本实用新型中推拉杆与第一橡胶塞结合后俯视状态的结构示意图；Fig. 3 is the structural schematic diagram of the top view state after the push-pull rod is combined with the first rubber plug in the present invention;

图4是本实用新型中活塞式储液管出口母鲁尔接头与移液通道连接状态，移液通道与活塞式离心管的第二橡胶塞结合状态的结构示意图；4 is a schematic structural diagram of the state in which the outlet female Luer connector of the piston type liquid storage tube is connected with the pipetting channel, and the state where the pipetting channel is combined with the second rubber stopper of the piston type centrifugal tube in the present invention;

图5是本实用新型中活塞式储液管出口母鲁尔接头与移液通道连接状态，移液通道与活塞式离心管的第二橡胶塞结合后俯视状态的结构示意图；5 is a structural schematic diagram of the state in which the outlet female Luer connector of the piston type liquid storage tube is connected to the pipetting channel of the present invention, and the top view state after the pipetting channel is combined with the second rubber stopper of the piston type centrifuge tube;

图6是本实用新型中活塞式储液管与活塞式离心管下端出口处母鲁尔接头的结构示意图；6 is a schematic structural diagram of the female luer joint at the outlet of the lower end of the piston-type liquid storage tube and the piston-type centrifuge tube in the present invention;

图7是本实用新型中活塞式离心管母鲁尔接头连接的一次性公鲁尔堵头结构示意图；7 is a schematic structural diagram of a disposable male Luer plug connected to a piston-type centrifuge tube female Luer connector of the present invention;

图8是本实用新型中用以与活塞式离心管出口母鲁尔接头连接的三通管示意图；Fig. 8 is the schematic diagram of the tee pipe used for connecting with the female luer joint of the piston type centrifuge tube outlet in the present invention;

图9是本实用新型活塞式储液管及活塞式离心管管壁刻度标注示意图。FIG. 9 is a schematic diagram of the scale marking on the wall of the piston-type liquid storage tube and the piston-type centrifuge tube of the present invention.

具体实施方式Detailed ways

为使本实用新型实现的技术手段、创作特征、达成目的与功效易于明白了解，下面结合具体实施方式，进一步阐述本实用新型。In order to make the technical means, creation features, achievement goals and effects of the present invention easy to understand and understand, the present invention will be further described below with reference to the specific embodiments.

参照图1-9，本具体实施方式采用以下技术方案：一种组合及可拆卸式富血小板血浆制备装置，包括推拉杆1、第一橡胶塞2、活塞式储液管3、活塞式离心管4和第二橡胶塞6，推拉杆1内端与第一橡胶塞2相配合，推拉杆1装配在活塞式储液管3内，活塞式储液管3下方装配有活塞式离心管4，活塞式离心管4下方开口处为一次性公鲁尔堵头8，活塞式离心管4内匹配有与活塞式离心管4内径一致的第二橡胶塞6，活塞式储液管3底部的移液通道5与第二橡胶塞6中间的开孔相套接配合。1-9, the present embodiment adopts the following technical solutions: a combined and detachable platelet-rich plasma preparation device, comprising a push-pull rod 1, afirst rubber stopper 2, a piston-typeliquid storage tube 3, and a piston-type centrifuge tube 4 and thesecond rubber plug 6, the inner end of the push-pull rod 1 is matched with thefirst rubber plug 2, the push-pull rod 1 is assembled in the piston typeliquid storage tube 3, and the piston typecentrifugal tube 4 is assembled under the piston typeliquid storage tube 3, The opening at the bottom of the pistontype centrifuge tube 4 is a disposablemale Luer plug 8. The pistontype centrifuge tube 4 is matched with asecond rubber stopper 6 with the same inner diameter as the pistontype centrifuge tube 4. Theliquid channel 5 is sleeved and matched with the opening in the middle of thesecond rubber plug 6 .

值得注意的是，所述的活塞式储液管3为筒柱状结构，筒柱状结构内匹配有与活塞式储液管3内径一致的第一橡胶塞2，第一橡胶塞2上的开孔上装配有推拉杆1。活塞式储液管3下方开口为第一母鲁尔接头31，第一母鲁尔接头31与移液通道5相匹配，并与活塞式离心管4相通。It is worth noting that the piston-typeliquid storage tube 3 is a cylindrical structure, and the cylinder-column structure is matched with afirst rubber plug 2 with the same inner diameter as the piston-typeliquid storage tube 3, and the opening on thefirst rubber plug 2 There is a push-pull rod 1 on it. The opening below the piston-typeliquid storage tube 3 is a firstfemale Luer connector 31 , and the firstfemale Luer connector 31 is matched with thepipetting channel 5 and communicated with the piston-type centrifuge tube 4 .

值得注意的是，所述的移液通道5固定在第二橡胶塞内，为一硬性通道，上端为第一公鲁尔接头51，可与活塞式储液管的第一母鲁尔接头31进行匹配，是血液在活塞式离心管及活塞式储液管内进行转移的通道。下端为移液通道旋转卡头52。It is worth noting that the pipettingchannel 5 is fixed in the second rubber stopper and is a rigid channel. The upper end is a firstmale Luer connector 51, which can be connected with the firstfemale Luer connector 31 of the piston-type liquid storage tube. Matching is the channel for blood to transfer in the piston-type centrifuge tube and the piston-type liquid storage tube. The lower end is the pipetting channelrotary chuck 52 .

值得注意的是，所述的活塞式离心管4为一直径较活塞式储液管3大的筒柱状装置，活塞式离心管4下方开口为第二母鲁尔接头7，第二母鲁尔接头7与一次性公鲁尔堵头8相匹配。It is worth noting that the piston-type centrifuge tube 4 is a cylindrical device with a larger diameter than the piston-typeliquid storage tube 3, and the opening below the piston-type centrifuge tube 4 is a secondfemale Luer connector 7, and the second female Luer Fitting 7 mates with disposablemale luer plug 8.

值得注意的是，所述的推拉杆1包括十字芯杆11，十字芯杆11上端装配有圆形薄片作为推拉板12，十字芯杆11下端设置有与第一橡胶塞2相匹配的推拉杆旋卡头13。It is worth noting that the push-pull rod 1 includes across core rod 11, the upper end of thecross core rod 11 is equipped with a circular sheet as the push-pull plate 12, and the lower end of thecross core rod 11 is provided with a push-pull rod matching thefirst rubber plug 2 Rotate thechuck 13.

值得注意的是，所述的活塞式储液管3的开口通过旋卡头13固定在第二橡胶塞6内，穿过第二橡胶塞6至活塞式离心管4内，与第二橡胶塞下端相齐平。It is worth noting that the opening of the piston-typeliquid storage tube 3 is fixed in thesecond rubber stopper 6 through thescrew chuck 13, passes through thesecond rubber stopper 6 into the piston-type centrifuge tube 4, and is connected with thesecond rubber stopper 6. Bottom is flush.

值得注意的是，所述的活塞式储液管3直径较活塞式离心管4短，使活塞式离心管保持密封的同时，活塞式储液管3可作为活塞式离心管4的推拉杆进行抽吸及注射。It is worth noting that the diameter of the piston-typeliquid storage tube 3 is shorter than that of the piston-typecentrifugal tube 4, so that while the piston-type centrifugal tube is kept sealed, the piston-typeliquid storage tube 3 can be used as a push-pull rod for the piston-typecentrifugal tube 4. Aspirate and inject.

值得注意的是，所述的活塞式离心管4的下端为第二母鲁尔接头7，可连接一次性公鲁尔堵头8，并可连接三通管9及无菌注射针，用于注射治疗及富血小板血浆凝胶的制备；所述的三通管9的中心设置有旋转阀91，三通管9的三个通道连接第二公鲁尔接头92、第三公鲁尔接头93和第三母鲁尔接头94。It is worth noting that the lower end of the piston-type centrifuge tube 4 is a secondfemale Luer connector 7, which can be connected to a disposablemale Luer plug 8, and can be connected to atee tube 9 and a sterile injection needle for use. Injection therapy and preparation of platelet-rich plasma gel; the center of the three-way tube 9 is provided with arotary valve 91, and the three channels of the three-way tube 9 are connected to the secondmale Luer connector 92 and the thirdmale Luer connector 93 and thirdfemale luer 94.

此外，所述的活塞式储液管及活塞式离心管管壁均设置有标记毫升数的标尺刻度，可用于明确抽液及转移的血液量。In addition, the walls of the piston-type liquid storage tube and the piston-type centrifuge tube are all provided with a scale marking the number of milliliters, which can be used to determine the amount of blood drawn and transferred.

本具体实施方式采用二次梯度离心法进行高浓度富血小板血浆制备，实际操作主要步骤如下。This specific embodiment adopts the secondary gradient centrifugation method to prepare high-concentration platelet-rich plasma, and the main steps of the actual operation are as follows.

1、将活塞式离心管与活塞式储液管的第二橡胶塞进行连接，再将活塞式离心管与其下端的三通管分离，连接无菌注射针，抽取2ml枸橼酸钠抗凝剂。取下无菌注射针，将活塞式离心管的母鲁尔接头与采血针相连接，无菌操作下取肘关节区进行静脉抽血，此时将活塞式储液管作为推拉杆，向后拉动活塞式储液管。抽取得到合适静脉血液至活塞式离心管内。1. Connect the piston-type centrifuge tube to the second rubber stopper of the piston-type liquid storage tube, then separate the piston-type centrifuge tube from the tee tube at the lower end, connect a sterile injection needle, and extract 2ml of sodium citrate anticoagulant. . Remove the sterile injection needle, connect the female luer connector of the piston-type centrifuge tube to the blood collection needle, and take the elbow joint area for venous blood sampling under aseptic operation. Pull the piston reservoir tube. Appropriate venous blood was drawn into a stopper-type centrifuge tube.

2、用一次性公堵头与抽得血液的活塞式离心管出口连接，使活塞式离心管完全封闭，缓慢摇匀，使枸橼酸钠抗凝剂与静脉血完全混合。将该装置放入离心机中，以900g离心力进行第一次离心，离心10分钟，由于血细胞成分沉降率不同，红细胞被沉入活塞式离心管的最底部并仅含少量血小板，中间主要为高浓度血小板及白细胞，上层为血浆并含少量血小板。2. Use a disposable male plug to connect to the outlet of the piston centrifuge tube that draws blood, so that the piston centrifuge tube is completely closed, and shake slowly to mix the sodium citrate anticoagulant with the venous blood completely. Put the device into a centrifuge, and perform the first centrifugation with a centrifugal force of 900g for 10 minutes. Due to the different sedimentation rates of blood cell components, the red blood cells are sunk into the bottom of the piston centrifuge tube and contain only a small amount of platelets, and the middle is mainly high. Concentration of platelets and white blood cells, the upper layer is plasma and contains a small amount of platelets.

3、第一次离心完毕，小心取出制备装置，放置于注射器支架上，拉动活塞式储液管的推拉杆，抽取活塞式离心管内上层、中层及红细胞层液平面以下1-2mm。使该部分液体完全进入活塞式储液管（使抽取得到的上层、中层及少部分红细胞层进入活塞式储液管内，暂时储存）。暂时储存。3. After the first centrifugation is completed, carefully take out the preparation device, place it on the syringe holder, pull the push-pull rod of the piston-type liquid storage tube, and extract the upper, middle and red blood cell layers in the piston-type centrifuge tube 1-2mm below the liquid level. Make this part of the liquid completely enter the piston-type storage tube (make the upper layer, middle layer and a small part of the red blood cell layer obtained by extraction into the piston-type storage tube for temporary storage). temporary storage.

4、活塞式储液管抽得上、中层液体后，打开一次性离心管堵头，将活塞式储液管作为活塞式离心管的推拉杆进行推送，使活塞式离心管内的红细胞排出并弃之。再次取一次性公鲁尔堵头将活塞式离心管出口连接，使活塞式离心管完全封闭。4. After the piston-type liquid storage tube can pump the upper and middle layers of liquid, open the plug of the disposable centrifuge tube, and push the piston-type liquid storage tube as the push-pull rod of the piston-type centrifuge tube, so that the red blood cells in the piston-type centrifuge tube are discharged and discarded. Of. Take a disposable male luer plug again to connect the outlet of the piston centrifuge tube to completely seal the piston centrifuge tube.

5、将储存在活塞式储液管的液体向活塞式离心管内推送，使液体完全送入活塞式离心管内后，将制备装置放入离心机内。选择离心力1100g，时间10min,进行第二次离心。5. Push the liquid stored in the piston-type liquid storage tube into the piston-type centrifuge tube, so that the liquid is completely sent into the piston-type centrifuge tube, and then put the preparation device into the centrifuge. Select centrifugal force 1100g, time 10min, and perform the second centrifugation.

6、第二次离心完毕，血液大致分为上层血浆、中间血小板及下层红细胞的三层。小心取出制备装置，放置于注射器支架上。将活塞式储液管作为活塞式离心管的推拉杆，拉动活塞式储液管，抽取上3/4液体，剩余1/4下层液体即为制备得到的富血小板血浆。6. After the second centrifugation, the blood is roughly divided into three layers: upper plasma, middle platelets and lower red blood cells. Carefully remove the preparation device and place it on the syringe holder. The piston-type liquid storage tube is used as the push-pull rod of the piston-type centrifuge tube, and the piston-type liquid storage tube is pulled to extract the upper 3/4 liquid, and the remaining 1/4 lower layer liquid is the prepared platelet-rich plasma.

7、将一次性无菌堵头拆下，连接通用无菌注射针头，再次将活塞式储液管作为活塞式离心管的推拉杆，即可进行组织或关节无菌穿刺注射治疗。若注射治疗部位为局部精细部位，可拉动活塞式储液管的推拉杆，将活塞式离心管内富血小板血浆抽吸至活塞式储液管内，将活塞式储液管与活塞式离心管分离，活塞式储液管的第一母鲁尔接头连接通用无菌注射针头，即可进行局部精细部位的注射治疗。7. Remove the disposable sterile plug, connect the general sterile injection needle, and use the piston-type liquid storage tube as the push-pull rod of the piston-type centrifuge tube again to perform aseptic puncture injection of tissue or joints. If the injection treatment site is a local fine part, the push-pull rod of the piston-type liquid storage tube can be pulled, the platelet-rich plasma in the piston-type centrifuge tube can be sucked into the piston-type liquid storage tube, and the piston-type liquid storage tube and the piston-type centrifugal tube can be separated. The first female luer connector of the piston-type liquid storage tube is connected to a general-purpose sterile injection needle, and the injection treatment of local delicate parts can be performed.

本具体实施方式的活塞式储液管及活塞式离心管均为长圆筒状管腔，下端呈一圆锥状底，可使血小板尽可能聚集在离心管下端，第一橡胶塞2及第二橡胶塞6底部均为与活塞式储液管3、活塞式离心管4圆锥形底部完全匹配的锥形设计，使富血小板血浆在离心后更好聚集，在将液体抽吸至活塞式储液管过程中达到完全转移，在将富血小板血浆注射过程中，使富集后的血小板完全注射至目标部位。The piston type liquid storage tube and the piston type centrifuge tube of this specific embodiment are both long cylindrical lumen, the lower end is a conical bottom, which can make the platelets gather at the lower end of the centrifuge tube as much as possible, thefirst rubber stopper 2 and the second rubber stopper The bottom of theplug 6 is a conical design that completely matches the conical bottom of the piston-typeliquid storage tube 3 and the piston-type centrifuge tube 4, so that the platelet-rich plasma is better aggregated after centrifugation, and the liquid is sucked into the piston-type liquid storage tube. In the process of achieving complete transfer, in the process of injecting platelet-rich plasma, the enriched platelets are completely injected to the target site.

本具体实施方式连接活塞式储液管3与活塞式离心管4的移液通道5上端为第一公鲁尔接头51，可与活塞式储液管下端开口的第一母鲁尔接头31相连接，移液管的中段为一细长管状通道，下端为移液通道旋转卡头52，可与第二橡胶塞6的开孔相匹配，长管状通道通入第二橡胶塞6底部。通过拉动活塞式储液管的推拉杆，可使活塞式离心管内的上层血浆通过移液通道抽吸至活塞式储液管内暂时储存。In this specific embodiment, the upper end of thepipetting channel 5 connecting the piston-typeliquid storage tube 3 and the piston-typecentrifugal tube 4 is a firstmale Luer connector 51, which can be connected with the firstfemale Luer connector 31 opened at the lower end of the piston-type liquid storage tube. Connection, the middle section of the pipette is a slender tubular channel, the lower end is a pipettingchannel rotary chuck 52, which can be matched with the opening of thesecond rubber stopper 6, and the long tubular channel leads to the bottom of thesecond rubber stopper 6. By pulling the push-pull rod of the piston-type liquid storage tube, the upper plasma in the piston-type centrifuge tube can be sucked into the piston-type liquid storage tube through the pipetting channel for temporary storage.

本具体实施方式的活塞式储液管3的下端开口为第一母鲁尔接头31，匹配有一次性无菌公鲁尔堵头，在抽液完毕后，将一次性堵头与活塞式离心管连接，可完全将活塞式离心管完全封闭，并放入富血小板血浆离心机内离心。活塞式离心管出口的母鲁尔接头可连接常用的各种型号无菌注射针头进行富血小板血浆注射治疗。The lower end opening of the piston-typeliquid storage tube 3 in this specific embodiment is a firstfemale Luer connector 31, which is matched with a disposable sterile male Luer plug. Tube connection can completely seal the piston centrifuge tube and put it into the platelet-rich plasma centrifuge for centrifugation. The female luer connector at the outlet of the piston centrifuge tube can be connected to various types of sterile injection needles commonly used for platelet-rich plasma injection therapy.

本具体实施方式的活塞式储液管及活塞式离心管的管壁印制有毫升标准刻度，可使抽取血液精准，衡量是否制备得到适量合格富血小板血浆。The wall of the piston-type liquid storage tube and the piston-type centrifuge tube of this specific embodiment is printed with a milliliter standard scale, which can accurately draw blood and measure whether an appropriate amount of qualified platelet-rich plasma can be prepared.

本具体实施方式还配备有常用的医用一次性三通管，可在三通的连接上段连接活塞式离心管或活塞式储液管，侧面通道连接另一抽取有凝血酶的注射器，双侧注射器缓慢推送，即可在三通管的第三个通道得到凝胶状态富血小板血浆。This specific embodiment is also equipped with a commonly used medical disposable three-way tube, which can be connected to a piston-type centrifuge tube or a piston-type liquid storage tube at the upper part of the connection of the three-way connection, and the side channel is connected to another syringe for extracting thrombin. Push slowly, and the platelet-rich plasma in gel state can be obtained in the third channel of the three-way tube.

本具体实施方式的橡胶塞采用的是常用的医用橡胶塞，材料采用丁基胶，它有极好的气密性和弹性，活塞式储液管、活塞式离心管、移液通道，芯杆、三通管、一次性堵头均采用高分子聚丙烯材料制作。The rubber stopper of this specific embodiment adopts the commonly used medical rubber stopper, and the material is butyl rubber, which has excellent air tightness and elasticity, piston type liquid storage tube, piston type centrifuge tube, pipetting channel, core rod , three-way pipe, one-time plug are made of high molecular polypropylene material.

以上显示和描述了本实用新型的基本原理和主要特征和本实用新型的优点。本行业的技术人员应该了解，本实用新型不受上述实施例的限制，上述实施例和说明书中描述的只是说明本实用新型的原理，在不脱离本实用新型精神和范围的前提下，本实用新型还会有各种变化和改进，这些变化和改进都落入要求保护的本实用新型范围内。本实用新型要求保护范围由所附的权利要求书及其等效物界定。The basic principles and main features of the present invention and the advantages of the present invention are shown and described above. It should be understood by those skilled in the art that the present invention is not limited by the above-mentioned embodiments. The above-mentioned embodiments and descriptions only illustrate the principle of the present invention. Without departing from the spirit and scope of the present invention, the present invention There will also be various changes and improvements in the new model, which all fall within the scope of the claimed invention. The claimed scope of the present invention is defined by the appended claims and their equivalents.

Claims

Translated fromChinese

1.一种组合及可拆卸式富血小板血浆制备装置，其特征在于，包括推拉杆(1)、第一橡胶塞(2)、活塞式储液管(3)、活塞式离心管(4)和第二橡胶塞(6)，推拉杆(1)内端与第一橡胶塞(2)相配合，推拉杆(1)装配在活塞式储液管(3)内，活塞式储液管(3)下方装配有活塞式离心管(4)，活塞式离心管(4)下方开口处为一次性公鲁尔堵头(8)，活塞式离心管(4)内匹配有与活塞式离心管(4)内径一致的第二橡胶塞(6)，活塞式储液管(3)底部的移液通道(5)与第二橡胶塞(6)中间的开孔相套接配合。1. a combined and detachable platelet-rich plasma preparation device, is characterized in that, comprises push-pull rod (1), first rubber stopper (2), piston type liquid storage tube (3), piston type centrifuge tube (4) and the second rubber plug (6), the inner end of the push-pull rod (1) is matched with the first rubber plug (2), the push-pull rod (1) is assembled in the piston-type liquid storage pipe (3), and the piston-type liquid storage pipe ( 3) A piston-type centrifuge tube (4) is installed below, the opening at the bottom of the piston-type centrifuge tube (4) is a disposable male Luer plug (8), and the piston-type centrifuge tube (4) is matched with a piston-type centrifuge tube. (4) The second rubber stopper (6) with the same inner diameter, the pipetting channel (5) at the bottom of the piston-type liquid storage tube (3) is sleeved and matched with the opening in the middle of the second rubber stopper (6).

2.根据权利要求1所述的一种组合及可拆卸式富血小板血浆制备装置，其特征在于，所述的活塞式储液管(3)为筒柱状结构，筒柱状结构内匹配有与活塞式储液管(3)内径一致的第一橡胶塞(2)，第一橡胶塞(2)上的开孔上装配有推拉杆(1),活塞式储液管(3)下方开口为第一母鲁尔接头(31)，第一母鲁尔接头(31)与移液通道(5)相匹配，并与活塞式离心管(4)相通。2. A combination and detachable platelet-rich plasma preparation device according to claim 1, wherein the piston-type liquid storage tube (3) is a cylindrical structure, and the cylindrical structure is matched with a piston The first rubber plug (2) with the same inner diameter of the type liquid storage tube (3), the opening on the first rubber plug (2) is equipped with a push-pull rod (1), and the opening below the piston type liquid storage tube (3) is the first rubber plug (2). A female Luer connector (31), the first female Luer connector (31) is matched with the pipetting channel (5) and communicated with the piston type centrifuge tube (4).

3.根据权利要求1所述的一种组合及可拆卸式富血小板血浆制备装置，其特征在于，所述的移液通道(5)固定在第二橡胶塞内，为一硬性通道，上端为第一公鲁尔接头(51)，第一公鲁尔接头(51)与活塞式储液管的第一母鲁尔接头(31)进行匹配，下端为移液通道旋转卡头(52)。3. A combination and detachable platelet-rich plasma preparation device according to claim 1, wherein the pipetting channel (5) is fixed in the second rubber stopper and is a rigid channel, and the upper end is A first male Luer connector (51), the first male Luer connector (51) is matched with the first female Luer connector (31) of the piston type liquid storage tube, and the lower end is a pipetting channel rotary chuck (52).

4.根据权利要求1所述的一种组合及可拆卸式富血小板血浆制备装置，其特征在于，所述的活塞式离心管(4)为一直径较活塞式储液管(3)大的筒柱状装置，活塞式离心管(4)下方开口为第二母鲁尔接头(7)，第二母鲁尔接头(7)与一次性公鲁尔堵头(8)相匹配。4. A combination and detachable platelet-rich plasma preparation device according to claim 1, wherein the piston-type centrifuge tube (4) is a larger diameter than the piston-type liquid storage tube (3) In the cylindrical device, the lower opening of the piston-type centrifuge tube (4) is a second female Luer connector (7), and the second female Luer connector (7) is matched with a disposable male Luer plug (8).

5.根据权利要求1所述的一种组合及可拆卸式富血小板血浆制备装置，其特征在于，所述的推拉杆(1)包括十字芯杆(11)，十字芯杆(11)上端装配有圆形薄片作为推拉板(12)，十字芯杆(11)下端设置有与第一橡胶塞(2)相匹配的推拉杆旋卡头(13)。5. A combination and detachable platelet-rich plasma preparation device according to claim 1, characterized in that, the push-pull rod (1) comprises a cross core rod (11), and the upper end of the cross core rod (11) is assembled A circular sheet is used as the push-pull plate (12), and the lower end of the cross core rod (11) is provided with a push-pull rod screw chuck (13) matching the first rubber plug (2).

6.根据权利要求1所述的一种组合及可拆卸式富血小板血浆制备装置，其特征在于，所述的活塞式储液管(3)的开口通过旋卡头(13)固定在第二橡胶塞(6)内，穿过第二橡胶塞(6)至活塞式离心管(4)内，与第二橡胶塞下端相齐平。6. A combination and detachable platelet-rich plasma preparation device according to claim 1, characterized in that, the opening of the piston-type liquid storage tube (3) is fixed on the second through the screw chuck (13). Inside the rubber stopper (6), pass through the second rubber stopper (6) into the piston-type centrifuge tube (4), and be flush with the lower end of the second rubber stopper.

7.根据权利要求1所述的一种组合及可拆卸式富血小板血浆制备装置，其特征在于，所述的活塞式储液管(3)直径较活塞式离心管(4)短。7 . The combined and detachable platelet-rich plasma preparation device according to claim 1 , wherein the diameter of the piston-type liquid storage tube ( 3 ) is shorter than that of the piston-type centrifuge tube ( 4 ). 8 .

8.根据权利要求1所述的一种组合及可拆卸式富血小板血浆制备装置，其特征在于，所述的活塞式离心管(4)的下端为第二母鲁尔接头(7)，第二母鲁尔接头(7)与一次性公鲁尔堵头(8)、三通管(9)或无菌注射针连接。8. A combination and detachable platelet-rich plasma preparation device according to claim 1, wherein the lower end of the piston-type centrifuge tube (4) is the second female Luer connector (7), the first The second female Luer connector (7) is connected with a disposable male Luer plug (8), a three-way tube (9) or a sterile injection needle.

9.根据权利要求1所述的一种组合及可拆卸式富血小板血浆制备装置，其特征在于，所述的活塞式储液管及活塞式离心管管壁均设置有标记毫升数的标尺刻度。9. A combination according to claim 1 and a detachable platelet-rich plasma preparation device, wherein the piston-type liquid storage tube and the piston-type centrifuge tube wall are all provided with a ruler scale marking the number of milliliters .