CN215866599U

Movatterモバイル変換

Info

Publication number: CN215866599U
Application number: CN202122105322.0U
Authority: CN
Inventors: 石汇林; 萧嘉繁; 朱春阳
Original assignee: Shenzhen Mindray Animal Medical Technology Co Ltd
Current assignee: Shenzhen Mindray Animal Medical Technology Co Ltd
Priority date: 2021-08-31
Filing date: 2021-08-31
Publication date: 2022-02-18
Anticipated expiration: 2031-08-31

Abstract

Description

Sample analyzer

Technical Field

The utility model relates to the field of sample analysis equipment, in particular to a sample analyzer.

Background

In the process of detecting a sample, a diluent is often used in a sample analyzer, for example, in sample detection such as impedance counting detection (counting detection of red blood cells and/or platelets by an impedance method), Hemoglobin (HGB) detection, optical detection (differential white blood cell count detection and reticulocyte detection), and the like, and the temperature of the diluent affects the consistency of detection parameters. In order to maintain the performance stability of the sample analyzer, a diluent heating function is generally provided in the sample analyzer to heat the diluent at a low temperature to a target heating temperature.

In the conventional technology, the heating implementation scheme of the diluent of the sample analyzer mainly includes the following two types: 1) according to the first scheme, a heating pool is arranged in a sample analyzer, but a liquid storage pool is not arranged, a quantifying device measures diluent from an external liquid storage barrel of the sample analyzer and conveys the diluent to the heating pool, and the diluent is heated by the heating pool and then conveyed to a reaction pool; 2) and according to the second scheme, a liquid storage tank and a heating tank are arranged in the sample analysis, the negative pressure source absorbs the diluent from the external liquid storage barrel and conveys the diluent to the liquid storage tank, the quantifying device measures the diluent from the liquid storage tank and conveys the diluent to the heating tank, and the diluent is heated by the heating tank and then conveyed to the reaction tank.

The two diluent heating implementation schemes have defects in specific application, and are specifically represented as follows: 1) in the first scheme, the diluent enters the heating pool from an inlet close to the bottom of the heating pool and is output from an outlet at the top of the heating pool. If the current sample is being tested, the quantification of the diluent is influenced, the result cannot be output, the continuous stability of the operation of the instrument is influenced, and when the external liquid storage barrel is replaced, bubbles in a channel between the external liquid storage barrel and the reaction tank need to be discharged, so that the replacement time is long. 2) In the second scheme, although when no diluent exists in the liquid storage barrel outside the machine, the diluent in the liquid storage tank can be used for continuously completing the test of the current sample, in the second scheme, the liquid storage tank and the heating tank are simultaneously arranged, so that the sample analyzer is large in size, high in cost and difficult to apply to a small-sized instrument.

SUMMERY OF THE UTILITY MODEL

The utility model aims to provide a sample analyzer, which aims to solve the technical problem that the storage and heating structure of diluent is unreasonable in arrangement in the traditional sample analyzer.

In order to achieve the purpose, the utility model provides the following scheme: a sample analyzer, comprising:

the reaction tank is used for preparing a sample into a sample;

the sampling device is used for collecting a sample and dispensing the sample into the reaction pool;

the liquid storage device comprises a liquid storage tank and a heating component, the liquid storage tank is used for storing diluent, and the heating component is used for heating the diluent in the liquid storage tank;

the quantifying device is arranged between the liquid storage tank and the reaction tank and is used for quantifying diluent from the liquid storage tank and conveying the diluent into the reaction tank;

a detection device for detecting the sample.

According to the sample analyzer provided by the utility model, the diluent is stored in the liquid storage tank, and the diluent in the liquid storage tank is heated by the heating component, so that the storage and heating functions of the diluent are realized. In the utility model, the quantifying device is arranged between the liquid storage tank and the reaction tank, so that when no diluent exists in the off-machine liquid storage barrel, the quantifying device can still measure the diluent from the liquid storage tank and convey the diluent to the reaction tank so as to continuously finish the test of the current sample. In addition, in the utility model, the liquid storage tank and the heating tank in the second traditional technical scheme are integrated into a whole, so that the cost and the volume of the sample analyzer are effectively reduced.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the structures shown in the drawings without creative efforts.

Fig. 1 is a schematic diagram illustrating a connection between a sample analyzer and an external liquid storage barrel according to a first embodiment of the present invention;

fig. 2 is a schematic connection diagram of a sample analyzer and an off-machine liquid storage barrel according to a second embodiment of the present invention;

fig. 3 is a schematic view illustrating a connection between a sample analyzer and an off-board liquid storage tank according to a third embodiment of the present invention.

The reference numbers illustrate:

100. a sample analyzer; 110. a reaction tank; 120. a liquid storage device; 121. a liquid storage tank; a. a liquid inlet; b. a liquid outlet; c. an air suction port; 122. a heating member; 130. a dosing device; 140. a negative pressure air source; 150. an air valve; 160. a liquid level detection section; 170. a second infusion pipeline; 180. a third infusion pipeline; 190. a two-position three-way valve; 191. a first on-off liquid valve; 192. a second switching fluid valve; 193. a three-way joint; 200. an external liquid storage barrel; 300. a first infusion pipeline.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

It should be noted that all the directional indicators (such as up, down, left, right, front, and rear … …) in the embodiment of the present invention are only used to explain the relative position relationship between the components, the motion situation, and the like in a specific posture, and if the specific posture is changed, the directional indicator is changed accordingly.

It will also be understood that when an element is referred to as being "secured to" or "disposed on" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or be indirectly connected to the other element through intervening elements.

In addition, the descriptions related to "first", "second", etc. in the present invention are for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In addition, technical solutions between various embodiments may be combined with each other, but must be realized by a person skilled in the art, and when the technical solutions are contradictory or cannot be realized, such a combination should not be considered to exist, and is not within the protection scope of the present invention.

The first embodiment is as follows:

In one embodiment, theheating member 122 is disposed in thereservoir 121 for directly heating the diluent in thereservoir 121, and the heating efficiency is high. Of course, in a specific application, theheating component 122 is not limited to this, for example, theheating component 122 may be disposed outside thereservoir 121 as an alternative embodiment, and in this alternative embodiment, theheating component 122 indirectly heats the diluent in thereservoir 121 by heating thereservoir 121.

In one embodiment, theheating member 122 is a heating rod, and the heating rod is inserted into theliquid storage tank 121. Of course, the type of theheating member 122 is not limited to this in the specific application, for example, as an alternative embodiment, theheating member 122 may be a heating plate covering the outside of theliquid storage tank 121.

In one embodiment, theheating member 122 is inserted into theliquid storage tank 121 from the bottom of theliquid storage tank 121, and this arrangement facilitates both installation of theheating member 122 and heating of the diluent in theliquid storage tank 121 by theheating member 122.

In one embodiment, theliquid storage tank 121 is provided with a liquid inlet a and a liquid outlet b, the liquid inlet a is used for being connected with thefirst infusion pipeline 300, so that thefirst infusion pipeline 300 delivers the diluent from the externalliquid storage barrel 200 into theliquid storage tank 121, that is, thefirst infusion pipeline 300 is connected between the externalliquid storage barrel 200 and the liquid inlet a. The outlet b is used for connecting with thequantitative device 130, so that thequantitative device 130 can quantitatively determine the diluent from thereservoir 121. The liquid inlet a and the liquid outlet b are used for the diluent to enter and discharge theliquid storage tank 121 respectively.

In one embodiment, the liquid outlet b is disposed at a side of thereservoir 121 and is disposed near a bottom of thereservoir 121. The liquid outlet b is arranged at the side part of theliquid storage tank 121, so that the interference between the liquid outlet b and theheating part 122 can be prevented, and the sealing difficulty of the liquid outlet b can be reduced; the liquid outlet b is arranged close to the bottom of theliquid storage tank 121, so that the diluent in theliquid storage tank 121 can be completely discharged through the liquid outlet b; and facilitates preventing air bubbles from entering the dosing means 130 from the liquid outlet b. Of course, in specific applications, as an alternative embodiment, the liquid outlet b may be disposed at the bottom of theliquid storage tank 121, which is also beneficial to completely discharging the diluent in theliquid storage tank 121 through the liquid outlet b; and may also help to prevent air bubbles from entering the dosing means 130 from the outlet b.

In one embodiment, theliquid storage tank 121 is further provided with a suction port c, thesample analyzer 100 further includes a negativepressure air source 140 and anair valve 150 disposed between the negativepressure air source 140 and the suction port c, the negativepressure air source 140 is configured to provide a driving force for the diluent to enter theliquid storage tank 121 from the liquid inlet a, and theair valve 150 is configured to control on/off of a channel between the negativepressure air source 140 and theliquid storage tank 121. Negativepressure air supply 140 is for providing the negative pressure device of negative pressure atmospheric pressure, switches on negativepressure air supply 140 andstock solution 121 whenpneumatic valve 150, and negativepressure air supply 140 can be the negative pressure environment withstock solution 121 to do benefit to and suck the diluent in thestock solution bucket 200 outside the machine to thestock solution 121 in. In this embodiment, the negative pressure of the pneumatic system is used to provide the driving force for the diluent to enter theliquid storage tank 121 from the liquid inlet a, and of course, in specific applications, other power components may also be used to provide the driving force for the diluent to enter theliquid storage tank 121 from the liquid inlet a.

In one embodiment, thereservoir 121 is further connected to a normal pressure air source (not shown), which can place thereservoir 121 in a normal pressure environment. In specific application, theliquid storage tank 121 can be selectively communicated with a normal-pressure air source or a negative-pressure air source 140, and when diluent in the externalliquid storage barrel 200 needs to be pumped into theliquid storage tank 121, theliquid storage tank 121 is switched to be communicated with the negative-pressure air source 140; when the diluent in theliquid storage tank 121 needs to be discharged and conveyed to thequantitative device 130, theliquid storage tank 121 is switched to be communicated with the normal pressure air source. Of course, in certain applications, thesample analyzer 100 may alternatively be configured to drive the discharge of the diluent from thereservoir 121 via a liquid pump or syringe or a positive pressure gas source.

In one embodiment, the air inlet c is formed at the top of thereservoir 121, so that when thereservoir 121 is not filled with the diluent, there is no fear that the diluent flows out through the air inlet c. Of course, in a specific application, as an alternative embodiment, the air inlet c may be disposed at a side portion of thereservoir 121 and near a top portion of thereservoir 121.

As an embodiment, thesample analyzer 100 is configured to: in the process of executing the detection item on the sample by thesample analyzer 100, when the information that the diluent in the off-machineliquid storage barrel 200 is insufficient or lower than the first preset liquid level is obtained and the detection item requires the diluent to be supplied into thereaction tank 110 is obtained, thequantitative device 130 is controlled to continue to convey the quantitative diluent from theliquid storage tank 121 to thereaction tank 110 until the detection item is completed. By adopting the control mode, when the off-boardliquid storage barrel 200 has no diluent, the quantifyingdevice 130 can continue to deliver the diluent to thereaction tank 110 from the interior of theliquid storage tank 121 until the current detection item being executed is completed, so that the change of the off-boardliquid storage barrel 200 cannot influence the detection of the sample, and the continuous stability of the operation of thesample analyzer 100 can be ensured.

As an embodiment, the liquid level inside the externalliquid storage barrel 200 may be detected by a liquid level detection device (not shown) to determine whether the diluent inside the externalliquid storage barrel 200 is lower than a first preset liquid level, so as to facilitate determining whether the diluent inside the externalliquid storage barrel 200 is about to be insufficient or is already insufficient. Of course, the method for detecting the shortage of the diluent in the externalliquid storage barrel 200 is not limited to this, and for example, as an alternative embodiment, it may be detected whether the diluent in the externalliquid storage barrel 200 is insufficient by a sensor provided in the firstliquid conveying pipeline 300.

As an embodiment, thesample analyzer 100 further comprises a liquidlevel detection component 160, the liquidlevel detection component 160 is configured to detect a liquid level in theliquid reservoir 121, and thesample analyzer 100 is further configured to: when the liquid level in theliquid storage tank 121 is judged to be lower than the second preset liquid level according to the feedback information of the liquidlevel detection part 160, the heating function of theheating part 122 is controlled to be turned off, so that theheating part 122 is prevented from being dried.

As an implementation mode, the second preset liquid level is slightly higher than or level with the height of the heating rod extending into theliquid storage tank 121, and the height of the heating rod extending into theliquid storage tank 121 is the distance from the top end of the heating rod to the inner bottom wall of theliquid storage tank 121. Adopt the second of this embodiment to predetermine the liquid level, both do benefit to and prevent thatheating element 122 from taking place the bad phenomenon of dry combustion method, do benefit to again and prevent to cause unnecessary when the liquid level inliquid storage tank 121 is still higher and close the heating function.

As an embodiment, the liquidlevel detecting part 160 is a float sensor, that is, in the present embodiment, the liquid level in theliquid reservoir 121 is monitored using a float sensor. Of course, in a specific application, the liquidlevel detection member 160 may also adopt other structures of the liquidlevel detection member 160, such as an electrode set, a capacitive sensor, an optical coupling detector, an ultrasonic detector, and the like.

In one embodiment, the switching component includes a two-position three-way valve 190, and three ports of the two-position three-way valve 190 are respectively communicated with thedosing device 130, thesecond infusion line 170 and thethird infusion line 180. The two-position three-way valve 190 has two working positions, when the two-position three-way valve 190 is at one of the working positions, the two-position three-way valve 190 conducts thequantitative device 130 and thesecond infusion pipeline 170, and thequantitative device 130 can quantitatively determine the diluent from theliquid storage tank 121; when the device is located at another working position, the two-position three-way valve 190 connects thequantitative device 130 and thethird infusion pipeline 180, and thequantitative device 130 can deliver a quantitative diluent to thereaction tank 110. In this embodiment, the switching component adopts a reversing valve, so that thequantitative device 130 can be respectively communicated with theliquid storage tank 121 and thereaction tank 110, and the device has a simple and compact structure and is convenient to control.

As an embodiment, the sampling device comprises a sampling needle, a sample suction pipeline, a liquid suction and discharge driving device and a motion driving device. The sample suction pipeline is respectively communicated with the sampling needle and the liquid suction and discharge driving device. The aspiration and drainage fluid driving device can provide a driving force for sucking fluid for the sampling needle and can provide a driving force for discharging fluid for the sampling needle. The sampling needle is installed on the motion drive arrangement, and the motion drive arrangement can drive the sampling needle and carry out spatial movement to make the sampling needle move to different stations, for example stand-by position, sampling position, branch appearance position etc..

In one embodiment, thesample analyzer 100 is a blood cell analyzer, and includes at least one of an impedance counting device, a hemoglobin detecting device, and an optical detecting device, and acorresponding reaction cell 110, wherein a diluent is required in the impedance counting, hemoglobin detecting, and optical detecting processes. The impedance counting detection device is used for counting and detecting red blood cells and/or blood platelets by an impedance method, the hemoglobin detection device is used for detecting the concentration of hemoglobin, and the optical detection device is used for classifying, counting and detecting white blood cells and/or counting and detecting reticulocytes by the optical detection element. Of course, thesample analyzer 100 may be an analyzer for performing other testing items in a particular application.

Example two:

referring to fig. 1 and 2, asample analyzer 100 according to the present embodiment is different from the first embodiment mainly in the arrangement of the switching member.

Specifically, in this embodiment, the switching component includes a firstswitching fluid valve 191, a secondswitching fluid valve 192, and a three-way joint 193, three ports of the three-way joint 193 are respectively communicated with thedosing device 130, thesecond infusion pipeline 170, and thethird infusion pipeline 180, the first switchingfluid valve 191 is disposed on thesecond infusion pipeline 170, and the secondswitching fluid valve 192 is disposed on thethird infusion pipeline 180. When the first switchingliquid valve 191 is in an open state and the second switchingliquid valve 192 is in a closed state, thequantitative device 130 is communicated with theliquid storage tank 121 through the secondliquid conveying pipeline 170, and thequantitative device 130 can quantitatively determine the diluent from theliquid storage tank 121; when the first switchingfluid valve 191 is in a closed state and the secondswitching fluid valve 192 is in an open state, thequantitative device 130 conducts thereaction cell 110 through thethird infusion pipeline 180, and thequantitative device 130 can deliver a fixed amount of the diluent to thereaction cell 110.

In addition to the above differences, the present embodiment provides other parts of thesample analyzer 100 that are optimized according to the embodiment and will not be described in detail herein.

Example three:

referring to fig. 1 and 3, the present embodiment provides asample analyzer 100, which is different from the first and second embodiments mainly in the control of the heating function of theheating element 122.

Specifically, in the present embodiment, the liquidlevel detection member 160 is not provided on thereservoir 121. Thesample analyzer 100 is configured to: and when the information that the diluent in the off-machineliquid storage barrel 200 is insufficient or is lower than the first preset liquid level is obtained, controlling to close the heating function of theheating component 122. In this embodiment, when the diluent in the externalliquid storage barrel 200 is detected to be insufficient or lower than the first preset liquid level, the heating function is turned off, so as to prevent theheating component 122 from being dried; however, this solution may cause unnecessary shutdown of the heating function in some situations when the liquid level in theliquid storage tank 121 is higher than theheating component 122 by a large amount after the current sample testing item is completed.

In addition to the above differences, the present embodiment provides other portions of thesample analyzer 100 that can be optimally designed with reference to one embodiment or two embodiments, and will not be described in detail herein.

Example four:

thesample analyzer 100 of the present embodiment is different from the first to third embodiments mainly in the control of the heating function of theheating element 122.

Specifically, in the present embodiment, the liquidlevel detection member 160 is also not provided on thereservoir 121. Thesample analyzer 100 is configured to: when the information that the diluent in the externalliquid storage barrel 200 is insufficient or is lower than the first preset liquid level is obtained, the operation times and/or the operation stroke of thequantitative device 130 are measured, the liquid discharge volume of the diluent discharged from theliquid storage tank 121 is calculated according to the operation times and the operation stroke of thequantitative device 130, and when the liquid level in theliquid storage tank 121 is judged to be lower than the second preset liquid level according to the calculated liquid discharge volume, the heating function of theheating component 122 is controlled to be turned off, so that theheating component 122 can be prevented from being dried. In this embodiment, the liquid level of the diluent in theliquid storage tank 121 is detected and judged by adopting a software deduction method, and the working principle is as follows: since the volume of thereservoir 121 is fixed and the one-time quantitative volume of thequantitative device 130 is also fixed, the number of times of operation of thequantitative device 130 is measured by software, the discharge volume of the diluent discharged from thereservoir 121 can be calculated, and the level of the remaining diluent in thereservoir 121 can be calculated.

The above description is only a preferred embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications and equivalents of the technical solutions of the present invention, which are made by using the contents of the present specification and the accompanying drawings, or directly/indirectly applied to other related technical fields, are included in the scope of the present invention.

Claims

1. A sample analyzer, comprising: the method comprises the following steps:

the reaction tank is used for preparing a sample into a sample;

a detection device for detecting the sample.

2. The sample analyzer of claim 1, wherein: the liquid storage pool is provided with a liquid inlet and a liquid outlet, and the liquid inlet is connected with a first infusion pipeline so that the first infusion pipeline can deliver diluent into the liquid storage pool from an external liquid storage barrel;

the liquid outlet is used for being connected with the quantifying device so as to enable the quantifying device to quantify the diluent from the liquid storage tank;

the liquid outlet is arranged at the side part of the liquid storage tank and is close to the bottom of the liquid storage tank; or the liquid outlet is arranged at the bottom of the liquid storage tank.

3. The sample analyzer of claim 2, wherein: the liquid storage pool is also provided with an air suction port, the sample analyzer further comprises a negative pressure air source and an air valve arranged between the negative pressure air source and the air suction port, the negative pressure air source is used for providing driving force for diluent entering the liquid storage pool from the liquid inlet, and the air valve is used for controlling the on-off of a channel between the negative pressure air source and the liquid storage pool;

the air suction port is arranged at the top of the liquid storage tank; or the air suction port is arranged on the side part of the liquid storage tank and is close to the top of the liquid storage tank.

4. The sample analyzer of claim 2, wherein: the sample analyzer is configured to: in the process that the sample analyzer executes a detection project on a sample, when information that diluent in the external liquid storage barrel is insufficient or lower than a first preset liquid level is obtained and the detection project needs to supply the diluent to the reaction tank, the quantitative device is controlled to continue conveying the quantitative diluent from the liquid storage tank to the reaction tank until the detection project is completed.

5. The sample analyzer of claim 4, wherein: the sample analyzer is further configured to: and when the information that the diluent in the external liquid storage barrel is insufficient or is lower than a first preset liquid level is acquired, controlling to close the heating function of the heating component.

6. The sample analyzer of claim 4, wherein: the sample analyzer further includes a liquid level detection component for detecting a liquid level within the reservoir, the sample analyzer further configured to: and when the liquid level in the liquid storage tank is judged to be lower than a second preset liquid level according to the feedback information of the liquid level detection component, the heating function of the heating component is controlled to be turned off.

7. The sample analyzer of claim 4, wherein: the sample analyzer is further configured to: when the information that diluent in the external liquid storage barrel is insufficient or is lower than a first preset liquid level is obtained, the action times and/or the action stroke of the quantifying device are measured, the liquid drainage volume of the diluent discharged from the liquid storage tank is calculated according to the action times and the action stroke of the quantifying device, and when the liquid level in the liquid storage tank is judged to be lower than a second preset liquid level according to the calculated liquid drainage volume, the heating function of the heating part is controlled to be turned off.

8. The sample analyzer of any of claims 1 to 7, wherein: the heating part is arranged in the liquid storage pool in a penetrating way; or,

the heater block is located outside the liquid storage tank to through the heating the liquid storage tank carries out indirect heating diluent in the liquid storage tank.

9. The sample analyzer of any of claims 1 to 7, wherein: the sample analyzer further comprises a second infusion pipeline, a third infusion pipeline and a switching part, the second infusion pipeline, the third infusion pipeline and the switching part are all arranged between the liquid storage tank and the reaction tank, one end of the second infusion pipeline is communicated with the liquid storage tank, one end of the third infusion pipeline is communicated with the reaction tank, and the quantifying device is communicated with the other end of the second infusion pipeline and the other end of the third infusion pipeline in a switchable manner through the switching part.

10. The sample analyzer of claim 9 wherein: the switching part comprises a two-position three-way valve, and three interfaces of the two-position three-way valve are respectively communicated with the quantitative device, the second infusion pipeline and the third infusion pipeline; or,

the switching part comprises a first switching liquid valve, a second switching liquid valve and a three-way joint, three interfaces of the three-way joint are respectively communicated with the quantifying device, the second infusion pipeline and the third infusion pipeline, the first switching liquid valve is arranged on the second infusion pipeline, and the second switching liquid valve is arranged on the third infusion pipeline.