CN214439179U - Z-axis driving mechanism of pipetting equipment - Google Patents

Abstract

The utility model discloses a Z-axis driving mechanism of a liquid-transfering device, which comprises a stand column, a motor, a sliding block, a balancing weight and a sliding block driving device, wherein a liquid-transfering component is connected with the sliding block through a connecting mechanism, and the stand column is arranged on a base; the sliding block driving device comprises a synchronous belt device, a first linear guide rail pair and a second linear guide rail pair which are vertically arranged; the first linear guide rail pair is vertically arranged in front of the upright post, a sliding block of the first linear guide rail pair is fixed on a sliding block, and the sliding block is connected with a front chord belt of a synchronous belt of the synchronous belt device; the second linear guide rail pair is vertically installed at the back of the stand column, and the balancing weight is fixed on a sliding block of the second linear guide rail pair and is connected with a rear chord belt of a synchronous belt of the synchronous belt device. The utility model discloses a balancing weight can balance the sliding block, move liquid subassembly and coupling mechanism's weight, reduces impact and vibration among the quick lift operation process, has improved driven stationarity and reliability, moves liquid equipment and can realize high-speed, high efficiency ground operation.

Description

Z-axis driving mechanism of pipetting equipment

[ technical field ]

The utility model relates to a move liquid equipment, especially relate to a move liquid equipment's Z axle actuating mechanism.

[ background art ]

Pipetting is an important operation content in the fields of biology, medicine and the like and is one of basic operations of various research experiments. Most of the work related to pipetting titration uses a pipetting gun, most of the processes of taking and discharging liquid of the instruments need manual operation, and the problems of liquid leakage, forgetting to rinse and the like easily occur.

The automatic liquid-transfering equipment is an automatic liquid-processing instrument, can be substituted for traditional liquid-transfering tool, can automatically implement high-accuracy liquid-processing tasks of gradient dilution, liquid-transfering and liquid-merging, and can be combined with detection instrument so as to implement high-effective and accurate detection of target object. The full-automatic operation process of the multi-station high-throughput automatic pipetting equipment can enable experimenters to get rid of complex experimental operation, effectively reduce human errors, improve the repeatability of experiments, reduce the cost, can also carry out process control and tracing, and can be widely applied to bioengineering, DNA plasmid purification, drug screening, ELISA reaction, PCR pretreatment, DNA sequencing treatment, clinical test sample treatment and high-throughput sample analysis of a blood station system.

According to the common operation flow of the medical industry, the automatic pipetting device has a complete pipetting cycle, which mainly comprises the following steps: assembling the suction head and the sleeve handle, setting the capacity, pre-washing the suction head, sucking liquid, discharging liquid (or other complex liquid-transferring operations), removing the suction head and the like.

The utility model with the patent number of CN201921356372.2 relates to a high-throughput and high-precision pipetting device, which comprises a mounting rack, a pipetting assembly and a lifting assembly for driving the mounting rack to lift, wherein the pipetting assembly comprises a piston rod base arranged on the mounting rack, a piston top plate positioned on the upper side of the piston rod base and a gun withdrawing head plate positioned on the lower side of the piston rod base; the mounting frame is provided with a driving mechanism for driving the piston top plate to move longitudinally, and the piston rod base is provided with a plurality of gun head rods which penetrate through the gun head withdrawing plate and are used for clamping gun heads, a piston rod matched with the gun head rods, a gun head pressing shaft for driving the gun head withdrawing plate to descend and a resetting piece for resetting the gun head withdrawing plate after descending; the piston rod and the gun pressing head shaft are driven by the piston top plate to move longitudinally; the gun head is installed through the lifting assembly, manual operation is not needed, the automation degree is high, and poor sealing performance between the gun head rod and the gun head caused by manual operation is avoided; the driving mechanism can drive the piston top plate to suck and spray liquid, so that high-flux and high-precision liquid transfer is realized.

However, this utility model discloses a lifting unit's sliding block all has very big weight with installing the liquid subassembly that moves on the sliding block, and when the sliding block was made straight reciprocating motion with moving the liquid subassembly, lifting unit load was big, and it is big to strike and vibrate at the operation in-process of going up and down fast, has reduced driven stationarity and reliability, moves liquid device and is difficult to realize high-speed, high efficiency ground and move.

[ summary of the invention ]

The to-be-solved technical problem of the utility model is to provide a driven stationarity and good reliability, the liquid-moving equipment's of being convenient for move liquid equipment Z axle actuating mechanism high-speed, high efficiency operation.

In order to solve the technical problem, the utility model adopts the technical scheme that the Z-axis driving mechanism of the liquid transferring equipment comprises an upright post, a motor, a sliding block, a balancing weight and a sliding block driving device, the liquid transferring equipment comprises a base, a liquid transferring assembly and a connecting mechanism, the liquid transferring assembly is connected with the sliding block through the connecting mechanism, and the upright post is arranged on the base; the sliding block driving device comprises a synchronous belt device, two groups of first linear guide rail pairs and two groups of second linear guide rail pairs, wherein the synchronous belt device is driven by the motor and is vertically arranged; the guide rails of the two groups of first linear guide rail pairs are vertically arranged in front of the upright post, the sliding blocks of the two groups of first linear guide rail pairs are fixed on the sliding blocks, and the sliding blocks are connected with a front chord belt of a synchronous belt of the synchronous belt device; the guide rails of the two groups of second linear guide rail pairs are vertically arranged at the back of the upright post, the balancing weights are fixed on the sliding blocks of the two groups of second linear guide rail pairs, and the balancing weights are connected with the rear chordal band of the synchronous belt device.

In the Z-axis driving mechanism of the pipetting device, the upright post is of a shell structure, and the synchronous belt device is arranged in a cavity of the upright post shell; the motor is arranged at the top of the upright post, and a driving wheel of the synchronous belt device is arranged on a motor shaft; the synchronous belt device comprises two connecting blocks, the front wall and the rear wall of the upright post shell respectively comprise vertical through grooves, and the first connecting block is arranged in the through groove of the front wall and is connected with a front chord belt and a sliding block of the synchronous belt; the second connecting block is arranged in the through groove of the rear wall and is connected with the rear chord belt and the balancing weight of the synchronous belt.

The Z-axis driving mechanism of the pipetting device comprises a Y-axis driving mechanism which is arranged on the base along the Y-axis direction; the Y-axis driving mechanism comprises a sliding block moving along the Y axis, and the bottom of the upright post is fixed on the sliding block of the Y-axis driving mechanism.

The connecting mechanism of the Z-axis driving mechanism of the liquid-moving equipment comprises an X-axis driving mechanism and a mounting rack, and the X-axis driving mechanism is mounted on the sliding block along the X-axis direction; the X-axis driving mechanism comprises a sliding block moving along the X axis, and the mounting frame is connected with the sliding block of the X-axis driving mechanism; the pipetting assembly is mounted in a mounting rack.

The Z-axis driving mechanism of the pipetting equipment comprises a pipetting assembly, a plurality of plunger cavities, a pipetting head withdrawing mechanism and a plurality of sleeve handles, wherein the pipetting assembly comprises a pipetting driving part, a plunger top plate; the liquid-transferring driving part comprises a liquid-transferring motor and a screw nut component; the mounting frame is in a door shape and comprises a top plate and two side plates; the liquid-transferring motor is arranged on the top plate of the mounting frame; the plunger cavity is vertically fixed at the lower part of the mounting rack and between the two side plates of the mounting rack; the tops of the plungers are connected with a plunger top plate, and the lower parts of the plungers are inserted into plunger cavities corresponding to the plunger cavities; the upper ends of the sleeve handles are arranged at the bottom of the plug cavity, and inner holes of the sleeve handles are communicated with the plunger cavity corresponding to the plunger cavity; the liquid-transfering motor is fixed on the top plate of the mounting frame, a lead screw of the lead screw nut component is connected with the lower end of the liquid-transfering motor, and a nut of the lead screw nut component is connected with the plunger top plate.

In the Z-axis driving mechanism of the liquid-moving equipment, the plunger cavity is connected with the inner sides of the side plates of the mounting rack, the liquid-moving driving part comprises a motor plate, two groups of third linear guide rail pairs and a driving frame, the driving frame comprises a top plate and two side plates, the motor plate is arranged at the front part of the top plate of the mounting rack, and the liquid-moving motor is fixed on the motor plate; the nut of the screw-nut component is arranged on the top plate of the driving frame, the guide rail of the third linear guide rail pair is vertically fixed on the inner side of the side plate of the mounting frame, and the slide block of the third linear guide rail pair is fixed on the outer side of the side plate of the driving frame; two ends of the plunger piston top plate are respectively connected with the lower ends of the two side plates of the driving frame.

The utility model discloses move liquid equipment Z axle actuating mechanism's balancing weight can balance the sliding block, move liquid subassembly and coupling mechanism's weight, reduces impact and vibration of quick lift operation in-process, has improved driven stationarity and reliability, moves liquid equipment can realize high-speed, high efficiency ground.

[ description of the drawings ]

The present invention will be described in further detail with reference to the accompanying drawings and specific embodiments.

Fig. 1 is the front view of the multistation high throughput liquid-transfering equipment of the embodiment of the utility model.

Fig. 2 is the top view of the multistation high throughput liquid-transfering equipment of the embodiment of the utility model.

Fig. 3 is the left side view of the multistation high throughput liquid-transfering equipment of the embodiment of the utility model.

Fig. 4 is the utility model discloses a multistation high throughput liquid-transfering equipment's perspective.

Fig. 5 is a perspective view of the Y-axis driving mechanism according to the embodiment of the present invention.

Fig. 6 is a cross-sectional view of the Y-axis drive mechanism according to the embodiment of the present invention.

Fig. 7 is a perspective view of the X-axis driving mechanism according to the embodiment of the present invention.

Fig. 8 is a sectional view of a Z-axis drive mechanism according to an embodiment of the present invention.

Fig. 9 is a perspective view of the pipette head and the pipette tip placement box according to the embodiment of the present invention.

Fig. 10 is a front view of the pipette head and the pipette tip placement box according to the embodiment of the present invention.

Fig. 11 is a left side view of the pipette head and pipette tip placement box of the embodiment of the present invention.

Fig. 12 is a top view of a pipetting head according to an embodiment of the invention.

Fig. 13 is a perspective view of the elastic pressing device according to the embodiment of the present invention.

Fig. 14 is a sectional view a-a in fig. 11.

Fig. 15 is a sectional view B-B in fig. 10.

Fig. 16 is a cross-sectional view of a pipetting mechanism according to an embodiment of the present invention.

Fig. 17 is a cross-sectional view of a pipetting sleeve handle according to an embodiment of the invention.

Fig. 18 is a cross-sectional view of a pipetting tip according to an embodiment of the invention.

FIG. 19 is a perspective view of the pipette tip placement box according to the embodiment of the present invention

Fig. 20 is a schematic view of the pipette head according to the embodiment of the present invention.

[ detailed description of the invention ]

The embodiment of the utility model provides a multistation high flux liquid-transfering equipment's structure is shown in fig. 1 to fig. 20, includingbase 02, Xaxle actuating mechanism 10, Yaxle actuating mechanism 20, Zaxle actuating mechanism 30, moveliquid aircraft nose 100 and two and moveliquid utensil 200.Pipetting head 100 includes a pipetting mechanism and an insertion mechanism. Each column ofpipetting instruments 200 comprises one pipettingtip placement box 90, oneliquid sample box 95 and one testtube placement box 96.

The Y-axis driving mechanism 20 is a linear module, and the linear module of the Y-axis driving mechanism 20 is installed on thebase 02 along the Y-axis direction. Includingcasing 21,Y axle motor 22, synchronous belt drive,drive block 23 and two sets oflinear guide pair 24,drive block 23 arranges the top atbar casing 21, and for hollow structure, including twocurb plates 231,Y axle motor 22 is fixed on thecurb plate 231 ofdrive block 23, and the main shaft ofY axle motor 22 stretches into in the inner chamber ofdrive block 23. The synchronous belt transmission device comprises asynchronous belt 25, adriving wheel 26 and twotension wheels 27, wherein thesynchronous belt 25 is arranged along the Y-axis direction, and two ends of thesynchronous belt 25 are fixed on theshell 21 of the linear module; adriving pulley 26 and twotension pulleys 27 are installed in the inner cavity of thedriving block 23, thedriving pulley 26 is disposed between the twotension pulleys 27, the bottoms of the two tension pulleys 27 press on the top surface of thetiming belt 25, thetiming belt 25 passes around the top of thedriving pulley 26, and the upper half circumference of thedriving pulley 26 is engaged with the inner circumference of thetiming belt 25. Theguide rails 241 of the two linearguide rail pairs 24 are horizontally fixed above thehousing 21.

The Z-axis driving mechanism 30 includes acolumn 31, a Z-axis motor 32, asliding block 33, a sliding block driving device and acounterweight 35, and the sliding block driving device includes asynchronous belt device 36, two linear guide rail pairs 37 and two linearguide rail pairs 38. Theguide rails 371 of the two linear guide pairs 37 are vertically installed in front of thevertical column 31, and thesliding blocks 33 are fixed on thesliding blocks 372 of the two linear guide pairs 37. Theguide rails 381 of the two linearguide rail pairs 38 are vertically installed at the back of theupright column 31, and the balancingweight 35 is fixed on thesliding blocks 382 of the two linearguide rail pairs 38. Thecolumn 31 is ahousing 21 structure, and thetiming belt device 36 is vertically arranged in a cavity of thehousing 21 of thecolumn 31. The Z-axis motor 32 is fixed on the top of theupright column 31, and thedriving wheel 361 of thesynchronous belt device 36 is arranged on the main shaft of the Z-axis motor 32. Thesynchronous belt device 36 comprises a connectingblock 362 and a connecting block 363, the front wall of the housing of the upright 31 is provided with a vertical throughgroove 311, the rear wall is provided with a vertical throughgroove 312, and the connectingblock 361 is arranged in thethrough groove 311 of the front wall and connects thefront chord 364 and thesliding block 33 of the synchronous belt. A connectingblock 362 is disposed in the throughslot 312 of the rear wall, connecting therear chord 365 of the timing belt and thecounterweight 35.

Theupright column 31 of the Z-axis driving mechanism 30 is fixed on theslide blocks 242 of the two groups of linearguide rail pairs 24 and is connected with thedriving block 23 of the linear module of the Y-axis driving mechanism 20.

TheX-axis driving mechanism 10 comprises a linear module, the linear module of theX-axis driving mechanism 10 comprises a synchronous belt linear sliding table 11 and two groups of linearguide rail pairs 12, the synchronous belt linear sliding table 11 is driven by anX-axis motor 13 and is arranged along the X-axis direction, and one end of the synchronous belt linear sliding table is fixed on asliding block 33 of the Z-axis driving mechanism 30. Theguide rails 121 of the two linearguide rail pairs 12 are fixed on the synchronous belt linear sliding table 11 along the X-axis direction.

The insertion mechanism of the pipettinghead 100 comprises amounting plate 01, an elasticpressing device 40, aninsertion driving device 50 and a press-fittingforce application device 60. Themounting plate 01 of the plug-in mechanism is fixed on thesliding blocks 122 of the two linearguide rail pairs 12 and is connected with the synchronous belt of the synchronous belt linear sliding table 11.

The elasticpressing device 40 comprises two groups of linearguide rail pairs 41, threecompression springs 42, three compressionspring guide columns 43, anupper top plate 44, alower top plate 45, an L-shaped connectingplate 46 and alimiting block 47. Theupper top plate 44 and thelower top plate 45 are transversely arranged, the lower ends of the pressurespring guide posts 43 are fixed on thelower top plate 45, and the three pressurespring guide posts 43 are transversely and separately arranged along thelower top plate 45. Theupper top plate 44 includes threeguide post holes 441, and theguide post holes 441 are arranged separately in the lateral direction of theupper top plate 44. The uppertop plate 44 is fixed in front of the mountingplate 01, and the upper end of the pressure spring guide post 43 passes through theguide post hole 441 of the uppertop plate 44 and is in sliding fit with theguide post hole 441. Thepre-tightening compression spring 42 is sleeved outside the compressionspring guide post 43 and is positioned between the uppertop plate 44 and thelower top plate 45. The guide rails 411 of the two linear guide rail pairs 41 are vertically fixed in front of the mountingplate 01 and are separately arranged on both sides of the uppertop plate 44 and thelower top plate 45. The L-shaped connectingplate 46 is disposed below thelower top plate 45, thelower top plate 45 is fixed on a vertical plate of the L-shaped connectingplate 46, and two ends of the L-shaped connectingplate 46 are respectively fixed on the slidingblocks 412 of the two sets of linear guide rail pairs 41. Thestop block 47 is fixed to the front of the mountingplate 01 below the L-shaped connectingplate 46.

Theinsertion driving device 50 comprises aninsertion motor 51, a door-shapedmotor base 52, ascrew nut assembly 53 and two groups of linear guide rail pairs 54. The door-shapedmotor base 52 comprises atop plate 521 and twoside plates 522, wherein thetop plate 521 of themotor base 52 is fixed on the transverse plate of the L-shaped connectingplate 46 of the elasticpressing device 40. Thecartridge motor 51 is vertically fixed on the top surface of thetop plate 521 of themotor base 52, and thelead screw 531 of the leadscrew nut assembly 53 is connected with the lower end of thecartridge motor 51.

The press-fittingforce application device 60 comprises two groups ofhooks 60A andhook closing mechanisms 60B for hooking the bearing flanges of thebox body 91 of the pipettetip placement box 90.

Each set ofhooks 60A comprises a connectingrod 61, aslider 62 and twohook rods 63, the lower ends of thehook rods 63 are provided with ahook head 631, and the hook heads 631 face inwards. The upper ends of the twohook rods 63 are fixed to the front and rear ends of the connectingrod 61, respectively, and theslider 62 is fixed to the bottom surface of the middle portion of the connectingrod 61. The two sides of the top surface of thetop plate 521 of themotor seat 52 are respectively provided with a slidinggroove 523 which is transversely arranged, the connectingrod 61 is arranged above the top plate of themotor seat 52 and is fixed on the slidingblock 62 at the bottom surface of the connectingrod 61 to be in sliding fit with the slidinggroove 523, and thehook 60A can transversely move along the slidinggroove 523.

Thehook folding mechanism 60B includes two sets of hook folding mechanisms symmetrically arranged left and right, and each set of hook folding mechanism includes aguide rod 64, aguide sleeve seat 65, apressure spring 66, aguide plate 67 and afeeler lever 68. Theguide rod 64 is transversely arranged above thetop plate 521 of themotor seat 52, the inner side of the guide rod is in sliding fit with a guide sleeve in aguide sleeve seat 65, and theguide sleeve seat 65 is fixed above thetop plate 521 of themotor seat 52. The outer end of theguide rod 64 is fixed to the connectingrod 61 with a fixingseat 69. The middle part of theguide rod 64 is provided with aflange 641, and thepressure spring 66 is sleeved on theguide rod 64 and is positioned between theguide sleeve seat 65 and theflange 641. The front end of thefeeler lever 68 is fixed to theflange 641 of theguide 64. Theguide plate 67 is disposed diagonally in front of the mountingplate 01, above and outside the rear end of thetrolley 68. The inner side of theguide plate 67 is a guide surface, and the rear end of thefeeler lever 68 is kept in contact with the guide surface of theguide plate 67 by the elastic force of thecompression spring 66.

The pipetting mechanism ofpipetting head 100 includes vertically arranged pipettingassembly 70, pipettingdrive member 80, mountingbracket 88 andpipetting head mechanism 89.

Pipetting assembly 70 comprises aplunger top plate 71, 96plungers 72 arranged in an 8 x 12 matrix, aplunger cavity 73 and 96 pipetting pockets 74 arranged in an 8 x 12 matrix.

Thepipetting driving part 80 comprises apipetting motor 81, ascrew nut component 82, amotor plate 83, two groups of linear guide rail pairs 84 and a drivingframe 85.

The mountingbracket 88 is door-shaped and includes atop plate 881 and twoside plates 882. Theguide 541 of thelinear guide pair 54 is vertically fixed on the inner side of theside plate 522 of themotor base 52, and theslider 542 of thelinear guide pair 54 is fixed on the outer side of theside plate 882 of the mountingframe 88. Thenut 532 of the leadscrew nut assembly 53 is mounted on thetop plate 881 of the mountingbracket 88.

Plunger cavity 73 is vertically disposed in a lower portion of mountingbracket 88 between twoside panels 882 of mountingbracket 88 and is secured inside twoside panels 882 of mountingbracket 88. The top of theplunger 72 is connected to theplunger top plate 71 and the lower portion is inserted into the correspondingplunger cavity 731 of theplunger cavity 73. The upper end of thepipetting handle 74 is arranged at the bottom of theplunger cavity 73, and the inner hole of thepipetting handle 74 is communicated with theplunger cavity 731 corresponding to theplunger cavity 73.

Themotor plate 83 is fixed to the front portion of thetop plate 881 of the mountingrack 88, and the liquid-transferringmotor 81 is fixed to themotor plate 83. Thelead screw 821 of the leadscrew nut assembly 82 is connected with the lower end of the liquid-transferringmotor 81.

The drivingframe 85 comprises atop plate 851 and twoside plates 852, thenut 822 of thescrew nut assembly 82 is installed on thetop plate 851 of the drivingframe 85, theguide rail 841 of the linearguide rail pair 84 is vertically fixed on the inner side of theside plate 882 of the mountingframe 88, and the slide block of the linearguide rail pair 84 is fixed on the outer side of theside plate 852 of the drivingframe 85. The two ends of theplunger top plate 71 are respectively connected with the lower ends of the two side plates of the drivingframe 85.

As shown in fig. 10, the pipettetip ejecting mechanism 89 includes a pipettetip ejecting plate 891, 4 compression springs 892, 4push rods 893, and a pipettetip ejecting plate 891 which is a perforated plate including handle holes arranged in an 8 × 12 matrix, the pipettetip ejecting plate 891 is arranged below theplunger cavity 73, and the pipette handle 74 passes through the handle holes of the pipettetip ejecting plate 891. Theplunger cavity 73 includes a flange 732 on each side of the lower portion thereof, the flange 732 includes two push rod holes, and the lower end of thepush rod 893 passes through the push rod holes of the flange 732 to be connected to theejector plate 891. Acompression spring 892 is fitted over thepushrod 893, with a lower end against the flange 732 and an upper end against the head of thepushrod 893. Before the twoside plates 852 of thedriving rack 85 descend to the stroke end, the lower ends of theside plates 852 touch thepush rods 893 to push the pipettetip withdrawing plate 891 to descend, and the pipettetip withdrawing plate 891 pushes all the usedpipette tips 93 downwards to separate from thepipette sheath handle 74.

As shown in fig. 17, the lower portion of thepipetting sleeve 74 is conical with a taper angle of 10 °. As shown in fig. 18, the upper portion of thepipetting tip 93 is formed in an inverted cone shape, the upper portion of the tipinner hole 931 is formed in an inverted cone shape, and the cone angle of the inverted cone shape is matched with the cone angle of the lower portion of thepipetting sleeve holder 74. A circle of inward-protruding interference fitannular belt 932 is arranged in the middle of the inverted cone hole, and the inward protruding height of the interference fitannular belt 932 is 0.1 mm.

As shown in fig. 19, the pipettetip placement cassette 90 includes acassette body 91, awell plate 92, and 96pipette tips 93 arranged in an 8 × 12 matrix on thewell plate 92. The upper edges of two opposite side plates of thebox body 91 of the pipettingtip placing box 90 are respectively provided with a bearingflange 911 which protrudes outwards, and the hook heads 631 of the two groups ofhooks 60A are positioned below the outer side of the bearingflange 911. The bottom surface of thebox body 91 is provided with a plurality of threaded holes, and thebox body 91 can be fixed on thebase 02 by the threaded holes on the bottom surface of thebox body 91.

Two rows of liquid-transferinginstruments 200 are separately arranged along the X-axis direction, each row of liquid-transferinginstruments 200 comprises three stations along the Y-axis direction on abase 02, a liquid-transferingtip placing box 90 is placed at the first station, aliquid sample box 95 is placed at the second station, a testtube placing box 96 is placed at the third station, and the testtube placing box 96 is provided with test tubes 961 (or deep hole plates) which are arranged in an8X 12 matrix according to the moment.

The embodiment of the utility model provides a moveliquid aircraft nose 100 and implement the working process of the cartridge of cover handle and suction head as follows:

1) the X-axis driving mechanism and the Y-axis driving mechanism move the liquid-transferingmachine head 100 to the upper part of a liquid-transferingsucker placing box 90, and the Z-axis driving mechanism drives the liquid-transferingmachine head 100 to descend until the lower end of the liquid-transferingsleeve handle 74 reaches the position of about 2mm of the upper end surface of the sucker; theinsertion motor 51 rotates, the feedscrew nut component 53 drives the liquid-transferring mechanism to move downwards, the liquid-transferringsleeve handle 74 is pre-inserted into an inner hole of the liquid-transferringsuction head 93, and the pressure of the liquid-transferring sleeve handle 74 pre-inserted into the liquid-transferringsuction head 93 is the pre-tightening pressure of the elasticpressing device 40;

2) after the liquid-transferringsleeve handle 74 is inserted into the liquid-transferringsucker 93, theinsertion motor 51 continues to rotate, the downward movement of the liquid-transferringsleeve handle 74 is blocked, themotor base 52 moves upwards by taking the nut of the screw-nut component 53 as a fulcrum, the three pressure springs 42 of the elasticpressing device 40 are compressed, themotor base 52 drives the two groups of hooks to move upwards, and thehook folding mechanism 60B is triggered at the same time; thefeeler lever 68 of thehook closing mechanism 60B moving upwards along themotor base 52 moves inwards along the guide surface of theguide plate 67, theguide rod 64 drives the two groups of hooks to close, and the hook heads 631 of the two groups of hooks hook the two bearingflanges 911 of thebox body 91 of the liquid-removing suctionhead placing box 90;

3) the pluggingmotor 51 further rotates, because the hook heads 631 of the two groups of hooks already hook thebox body 91 of the liquid-transferring suctionhead placing box 90, themotor base 52 cannot move upwards relative to the liquid-transferring suctionhead placing box 90, the pluggingmotor 51 can only drive the liquid-transferring mechanism to move downwards, the interference resistance between the liquid-transferringsuction head 93 and the liquid-transferringsleeve handle 74 is overcome, the liquid-transferringsleeve handle 74 is pressed into the inner hole of the liquid-transferringsuction head 93, and the press-fitting of the liquid-transferringsuction head 93 and the liquid-transferringsleeve handle 74 is completed;

4) theinsertion motor 51 rotates reversely, and thehook folding mechanism 60B firstly releases thehook pipette tip 93 to put two groups of hooks: the elasticpressing device 40 pushes themotor base 52 to drive the two groups of hooks to move downwards and trigger thehook folding mechanism 60B at the same time; thefeeler lever 68 moving downwards along themotor base 52 moves outwards along the guide surface of theguide plate 67 under the action of the second spring, theguide rod 64 drives the two groups of hooks to open, and the hook heads 631 of the two groups of hooks release the two bearingflanges 911 of thebox body 91 of the liquid-removing suctionhead placing box 90;

5) in the process of releasing thebox body 91 of the pipettingtip placing box 90 by the hook heads 631 of the two groups of hooks, the insertingmotor 51 drives the pipetting mechanism to move upwards through thescrew nut component 53, the inserting mechanism resets, the pipetting sleeve handle 74 of thepipetting component 70 drives thepipetting tip 93 to be drawn out from thebox body 91 of the pipettingtip placing box 90, the Z-axis driving mechanism of the pipetting equipment drives the assembling mechanism to ascend, the tip inserting work is completely finished, and the next liquid extracting work can be carried out.

The utility model discloses in the cartridge working process of the cover handle of above embodiment and suction head, to move the back in the cover handle of liquid subassembly inserts the hole of liquid suction head, the couple of insertion equipment grabs the bearing flange of the box body that liquid suction head placed the box, further exerts pressure to moving the liquid subassembly, will move liquid the liquid handle pressure equipment of liquid subassembly lower part again to move in the hole of liquid suction head. The downward press-fitting force of the liquid-transferring component is balanced by the pulling force applied to the bearing flange by the hook, and cannot be transmitted to an X-axis driving mechanism and a Z-axis driving mechanism of the liquid-transferring equipment through the mounting plate, so that the X-axis driving mechanism and the Z-axis driving mechanism deform to influence the insertion effect of a suction head and a sleeve handle of the high-throughput liquid-transferring equipment.

The embodiment of the utility model provides a multistation high flux liquid-transfering equipment moves liquid working process explains with first row liquid-transferingappliance 200A as an example, and liquid-transfering process that second row liquid-transferingappliance 200B is the same, and the description is not repeated:

1) the X-axis driving mechanism and the Y-axis driving mechanism move the liquid-transferingmachine head 100 to the position above the liquid-transfering suctionhead placing box 90A at the first station of the first row of liquid-transfering instruments 200A, and the Z-axis driving mechanism drives the liquid-transferingmachine head 100 to descend until the lower end of the liquid-transferingsleeve handle 74 reaches about 2mm of the upper end surface of the suction head;

2) the press-fitting process of the liquid-transferringsleeve handle 74 and the first liquid-transferringsuction head 93 is completed by the action of the inserting mechanism of the liquid-transferringmachine head 100, the liquid-transferringmachine head 100 is driven by the Z-axis driving mechanism to lift, and the lower end of the first liquid-transferringsuction head 93 leaves thebox body 91 of the liquid-transferring suctionhead placing box 90A;

3) the Y-axis driving mechanism drives the liquidtransfer machine head 100 to move to the position above theliquid sample box 95A at the second station along the Y axis, the Z-axis driving mechanism drives the liquidtransfer machine head 100 to descend, the first liquidtransfer suction head 93 is inserted into liquid in theliquid sample box 95A, the liquid transfer mechanism of the liquidtransfer machine head 100 acts to suck quantitative liquid in theliquid sample box 95A, and the Z-axis driving mechanism drives the liquidtransfer machine head 100 to ascend;

4) the Y drive mechanism drives and movesliquid aircraft nose 100 and places the top ofbox 96A along the Y axle removal to third station test tube, Z axle drive mechanism drives and movesliquid aircraft nose 100 and descends, moveliquid suction head 93 and insert the test tube and place in thetest tube 961 ofbox 96A (or the deep hole of deep hole board), moveliquid aircraft nose 100 move liquid mechanism action, arrange the test tube and place in thetest tube 961 ofbox 96A (or the deep hole of deep hole board) with having absorbed quantitative liquid, Z axle drive mechanism drives and movesliquid aircraft nose 100 and rise, Y drive mechanism drives and movesliquid aircraft nose 100 and reset.

The utility model discloses the work process that the multistation high flux pipetting device moved liquid does not need the manual work to trade the box above embodiment, can the automation mechanized operation, and work efficiency is high.

The embodiment of the utility model provides a multistation high flux moves liquid equipment ration and mixes the working process of liquid still includes following step on the basis of the working process that moves the liquid in front:

5) after the Y-axis driving mechanism drives the liquid-transferingmachine head 100 to reset along the Y-axis direction, the liquid-transferingmachine head 100 is moved to the upper side of the first row of liquid-transfering instruments 200A and the first station liquid-transfering suctionhead placing box 90A, the Z-axis driving mechanism drives the liquid-transferingmachine head 100 to descend, and the first liquid-transferingsuction head 93 is inserted into thepore plate 92 of the first station liquid-transfering suctionhead placing box 90A;

6) the pipettehead withdrawing mechanism 89 of the pipetting mechanism of thepipette head 100 operates, and 96pipette tips 93 are all unloaded into theorifice plate 92 of the first station pipettetip placing box 90A;

7) the Z-axis driving mechanism drives the liquid-transferingmachine head 100 to lift, the X-axis driving mechanism drives the liquid-transferingmachine head 100 to move to the second row of liquid-transferingapparatus 200B above the liquid-transfering suctionhead placing box 90B at the first station,

8) the insertion mechanism of the liquid-transfering head 100 acts to complete the press-fitting process of the liquid-transferingsleeve handle 74 and the second liquid-transferinghead 93 in the liquid-transferinghead placing box 90B, the Z-axis driving mechanism drives the liquid-transfering head 100 to rise, and the lower end of the second liquid-transferinghead 93 leaves thebox body 91 of the liquid-transferinghead placing box 90B;

9) the Y-axis driving mechanism drives the liquidtransfer machine head 100 to move to the position above theliquid sample box 95B of the second row of second stations along the Y axis, the Z-axis driving mechanism drives the liquidtransfer machine head 100 to descend, the second liquidtransfer suction head 93 is inserted into liquid in theliquid sample box 95B, the liquid transfer mechanism of the liquidtransfer machine head 100 acts to suck quantitative liquid in theliquid sample box 95B, and the Z-axis driving mechanism drives the liquidtransfer machine head 100 to ascend;

10) the Y-axis driving mechanism drives the liquid-transfering head 100 to move to the upper side of the first row of third station testtube placing box 96A along the Y-axis, the Z-axis driving mechanism drives the liquid-transfering head 100 to descend, the second liquid-transferingsuction head 93 is inserted into the test tube 961 (or the deep hole of the deep hole plate) of the testtube placing box 96A, the liquid-transfering mechanism of the liquid-transfering head 100 acts to discharge the quantitative liquid in the suckedliquid sample box 95B into the test tube 961 (or the deep hole of the deep hole plate) of the testtube placing box 96A;

11) the Z-axis driving mechanism drives thepipetting head 100 to lift, and the Y-driving mechanism and the X-driving mechanism drive thepipetting head 100 to reset.

The utility model discloses the ration of two kinds of different liquid of above embodiment multistation high flux liquid-transfering equipment is got liquid and the mixed process does not need the manual work to trade the box, can the automation mechanized operation, once only accomplishes, and work efficiency is high.

The utility model discloses above embodiment Z axle actuating mechanism's balancing weight can balance sliding block, X axle actuating mechanism and move the weight of liquid aircraft nose, reduces the load of Z axle motor, reduces X axle actuating mechanism and moves the impact and the vibration of liquid aircraft nose fast lifting in-process, has improved driven stationarity and reliability, moves liquid equipment and can realize high-speed, high efficiency ground operation.

Claims (6)

1. A Z-axis driving mechanism of a pipetting device comprises an upright post, a motor, a sliding block and a sliding block driving device, wherein the pipetting device comprises a base, a pipetting assembly and a connecting mechanism, the pipetting assembly is connected with the sliding block through the connecting mechanism, and the upright post is arranged on the base; the sliding block driving device comprises a synchronous belt device, two groups of first linear guide rail pairs and two groups of second linear guide rail pairs, wherein the synchronous belt device is driven by the motor and is vertically arranged; the guide rails of the two groups of first linear guide rail pairs are vertically arranged in front of the upright post, the sliding blocks of the two groups of first linear guide rail pairs are fixed on the sliding blocks, and the sliding blocks are connected with a front chord belt of a synchronous belt of the synchronous belt device; the guide rails of the two groups of second linear guide rail pairs are vertically arranged at the back of the upright post, the balancing weights are fixed on the sliding blocks of the two groups of second linear guide rail pairs, and the balancing weights are connected with the rear chordal band of the synchronous belt device.

2. The Z-axis drive mechanism for a pipetting device according to claim 1 characterized in that the column is of a housing construction and the timing belt arrangement is arranged in a cavity of the column housing; the motor is arranged at the top of the upright post, and a driving wheel of the synchronous belt device is arranged on a motor shaft; the synchronous belt device comprises two connecting blocks, the front wall and the rear wall of the upright post shell respectively comprise vertical through grooves, and the first connecting block is arranged in the through groove of the front wall and is connected with a front chord belt and a sliding block of the synchronous belt; the second connecting block is arranged in the through groove of the rear wall and is connected with the rear chord belt and the balancing weight of the synchronous belt.

3. The Z-axis drive mechanism for a pipetting apparatus according to claim 1 characterized in that the pipetting apparatus comprises a Y-axis drive mechanism mounted on the base in the Y-axis direction; the Y-axis driving mechanism comprises a sliding block moving along the Y axis, and the bottom of the upright post is fixed on the sliding block of the Y-axis driving mechanism.

4. The Z-axis drive mechanism of a pipetting apparatus as recited in claim 1 wherein the connection mechanism includes an X-axis drive mechanism and a mounting frame, the X-axis drive mechanism being mounted on the slide block in the X-axis direction; the X-axis driving mechanism comprises a sliding block moving along the X axis, and the mounting frame is connected with the sliding block of the X-axis driving mechanism; the pipetting assembly is mounted in a mounting rack.

5. The Z-axis drive mechanism of pipetting equipment of claim 4 wherein the pipetting assembly comprises a pipetting drive member, a plunger top plate, a plurality of plungers, a plunger cavity, an aspiration head withdrawal mechanism and a plurality of hubs; the liquid-transferring driving part comprises a liquid-transferring motor and a screw nut component; the mounting frame is in a door shape and comprises a top plate and two side plates; the liquid-transferring motor is arranged on the top plate of the mounting frame; the plunger cavity is vertically fixed at the lower part of the mounting rack and between the two side plates of the mounting rack; the tops of the plungers are connected with a plunger top plate, and the lower parts of the plungers are inserted into plunger cavities corresponding to the plunger cavities; the upper ends of the sleeve handles are arranged at the bottom of the plug cavity, and inner holes of the sleeve handles are communicated with the plunger cavity corresponding to the plunger cavity; the liquid-transfering motor is fixed on the top plate of the mounting frame, a lead screw of the lead screw nut component is connected with the lower end of the liquid-transfering motor, and a nut of the lead screw nut component is connected with the plunger top plate.

6. The Z-axis driving mechanism of pipetting device as recited in claim 1 wherein the plunger cavity is connected to the inside of the side plates of the mounting rack, the pipetting driving member comprises a motor plate, two sets of third linear guide pairs and a driving rack, the driving rack comprises a top plate and two side plates, the motor plate is mounted on the front of the top plate of the mounting rack, and the pipetting motor is fixed on the motor plate; the nut of the screw-nut component is arranged on the top plate of the driving frame, the guide rail of the third linear guide rail pair is vertically fixed on the inner side of the side plate of the mounting frame, and the slide block of the third linear guide rail pair is fixed on the outer side of the side plate of the driving frame; two ends of the plunger piston top plate are respectively connected with the lower ends of the two side plates of the driving frame.

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