CN212816189U - Multi-electrode optical fiber microscopic endoscopic probe - Google Patents

Abstract

Translated fromChinese

本发明公开了一种多极光纤显微内窥探头，包括：铠装外壳及光纤子探头，所述铠装外壳内部包含有三个所述光纤子探头；所述铠装外壳包括：固定卡槽和定位方槽；所述光纤子探头包括：微型显微物镜组、铠装套、包裹外壳、限位器、成像光纤束；其中：所述固定卡槽设置于所述铠装外壳的顶端；所述定位方槽位于所述铠装外壳内；所述微型显微物镜组设于所述光纤子探头最前端；所述铠装套一端与所述微型显微物镜组连接，另一端与所述包裹外壳连接；所述限位器设于所述包裹外壳的表面，为长条状。本发明可以从不同的视角观察残余肿瘤存活情况，最全面的反应消融术对肿瘤杀伤效果，避免肿瘤残余，降低患者术后因肿瘤残余或者转移带来的复发风险。

The invention discloses a multi-pole optical fiber microendoscope probe, comprising: an armored casing and an optical fiber sub-probe, wherein the armored casing contains three of the optical fiber sub-probes; the armored casing includes: a fixing slot and a positioning square slot; the optical fiber sub-probe includes: a microscopic objective lens group, an armored sheath, a wrapping shell, a limiter, and an imaging fiber bundle; wherein: the fixing slot is arranged on the top of the armored shell; The positioning square groove is located in the armored shell; the microscopic objective lens group is arranged at the front end of the optical fiber sub-probe; one end of the armored sleeve is connected to the microscopic objective lens group, and the other end is connected to the optical fiber sub-probe. The wrapping shell is connected; the stopper is arranged on the surface of the wrapping shell and is in the shape of a long strip. The present invention can observe the survival of residual tumor from different perspectives, the most comprehensive response ablation to tumor killing effect, avoid tumor residual, and reduce the recurrence risk of patients due to tumor residual or metastasis after operation.

Description

Multi-electrode optical fiber microscopic endoscopic probe

Technical Field

The invention relates to the field of medical instruments, in particular to a multi-pole optical fiber microscopic endoscopic probe.

Background

The death rate of liver cancer is the third place in the middle-level malignant tumor, 4 people die from liver cancer every 5 minutes in the world on average, and the death rate of liver cancer accounts for 55 percent of the world in China. Minimally invasive interventions, represented by ablation, are currently the most widely used and promising diagnostic and therapeutic means. However, the problem of the current clinical important requirement is that the focus is quickly and accurately positioned and qualified in the operation, the treatment response is monitored in real time, the tumor residue is avoided, and the postoperative treatment and follow-up scheme is individually formulated.

Currently, ablation guiding technologies mainly include CT, MRI, US, and the like. CT positioning is accurate, but artifacts exist due to motion interference, MRI resolution is high, but equipment volume is large, cost is high, and US instruments are small, low in cost, poor in accuracy and have dead corners and blind areas. The traditional medical image navigation operation is only a minimally invasive operation performed by defining a tumor boundary, and the traditional medical image navigation operation cannot go deep into the tumor to observe the actual killing effect of tumor cells, so that the tumor remains and the treatment effect of patients is influenced.

With the rapid progress of medical imaging, the development of image-guided liver cancer ablation treatment technology is greatly promoted.

The confocal microscopic endoscope is one of the latest endoscopic imaging technologies at present, and the existing fiber confocal microscope reaches micron-scale optical resolution and can completely realize cell-level and subcellular microscopic imaging on tissue cells. The system can perform in-vivo high-resolution imaging while performing common endoscopic examination, acquire the histological imaging result of the mucosa in real time, and provide help for doctors to perform clinical diagnosis and cancer detection.

The optical fiber micro-endoscope probe is one of the key technologies of a confocal micro-endoscope and is used for focusing divergent light emitted by a single optical fiber of an optical fiber bundle on a sample to excite fluorescence, collecting the fluorescence generated by the sample and coupling the fluorescence into the single optical fiber of the optical fiber bundle. The micro-imaging device is used for observing and analyzing the image information of the sample surface or the interior, and realizes the micro-scale high-resolution optical microscopic tumor cell imaging.

The existing optical fiber microscopic imaging equipment is a monopole microscopic endoscopic probe. The monopole probe can not realize multi-site simultaneous detection, can not observe the survival condition of the residual tumor from different visual angles, has poor extension and bending performance, can not comprehensively reflect the killing effect of the ablation on the tumor, has low resolution, has low detection efficiency, and can not realize the online real-time monitoring on the residual tumor in the operation. The risk of recurrence of the patient after surgery due to tumor residues or metastases is still high.

Disclosure of Invention

Aiming at the defects in the technology, the invention provides a multipolar optical fiber micro-endoscopic probe.

The technical scheme adopted by the invention is as follows: a multipolar optical fiber microscopic endoscopic probe comprises an armored shell and optical fiber sub-probes, wherein the armored shell internally comprises three optical fiber sub-probes; the armor shell includes: a fixed clamping groove and a positioning square groove; the fiber optic sub-probe comprises: the micro-objective lens group, the armor sleeve, the wrapping shell, the limiter and the imaging optical fiber bundle; wherein:

the fixed clamping groove is arranged at the top end of the armored shell;

the positioning square groove is positioned in the armor shell;

the micro microscope objective group is arranged at the foremost end of the optical fiber sub probe;

one end of the armor sleeve is connected with the micro objective lens group, and the other end of the armor sleeve is connected with the wrapping shell;

the limiter is arranged on the surface of the wrapping shell and is in a long strip shape.

Preferably, the multipole fiber micro-endoscopic probe further comprises an imaging fiber bundle; wherein:

the imaging optical fiber bundle is positioned in the optical fiber sub-probe and is arranged behind the micro microscope objective group.

Preferably, the positioning square groove is formed by embedding three 120-degree long-strip square grooves in the armored shell.

Preferably, the depth of the positioning square groove is the same as the height of the stopper.

Preferably, the armor shell is cylindrical and made of medical stainless steel.

Preferably, the number of optical fibers of the imaging fiber bundle is not particularly limited and ultrafine imaging fibers are used.

Preferably, the armor is a cylindrical shell constructed of a memory alloy and the memory alloy is fabricated into a 120 degree bend configuration that has been predetermined.

Preferably, the wrapping shell is made of medical stainless steel.

By the technical scheme, the multipolar optical fiber microscopic endoscopic probe disclosed by the invention at least has the following advantages and beneficial effects:

the invention discloses a multipolar optical fiber microscopic endoscopic probe which is obviously different from the traditional optical fiber microscopic probe and is provided with three optical fiber sub-probes, each optical fiber sub-probe can independently image, and the neck part of each optical fiber sub-probe is made of an armor sleeve made of memory alloy. When surveying, can realize extending in order to three direction, consequently can follow the remaining tumour condition of surviving of different visual angles observation, the multiple spot detects simultaneously, instructs doctor in real time to melt the operation, and the most comprehensive reaction melts the operation and kills and kill the effect to the tumour, avoids the tumour to remain, reduces the patient postoperative because of the tumour remains or the relapse risk that the metastasis brought.

Drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings needed to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art that other embodiments and drawings thereof can be obtained according to the embodiments shown in the drawings without any creative effort.

FIG. 1 is a schematic structural diagram of a multi-pole optical fiber micro-endoscopic probe according to an embodiment of the present invention;

FIG. 2 is a schematic structural diagram of a fiber optic sub-probe according to an embodiment of the present invention;

FIG. 3 is a schematic view of an extended fiber optic sub-probe of the multi-stage fiber optic micro-endoscopic probe according to an embodiment of the present invention;

fig. 4 is a schematic structural diagram of an optical microscopic detection apparatus according to an embodiment of the present invention.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, embodiments of the present invention will be described in detail with reference to the accompanying drawings. It is to be understood that the described embodiments are merely a few embodiments of the invention, and not all embodiments. All embodiments obtained by those skilled in the art based on the embodiments of the present invention without any inventive work belong to the protection scope of the present invention.

An embodiment of the present invention provides a multi-pole optical fiber micro-endoscopic probe, and fig. 1 is a schematic structural view of the multi-pole optical fiber micro-endoscopic probe, and fig. 2 is a schematic structural view of the optical fiber sub-probe. The multi-pole optical fiber micro-endoscopic probe comprises: the optical fiber probe comprises anarmored case 10 andoptical fiber sub-probes 11, wherein thearmored case 10 internally comprises threeoptical fiber sub-probes 11. Thearmor case 10 includes: afixed card slot 101 and apositioning square slot 102; theoptical fiber sub-probe 11 includes: a micro microscope group 111, anarmor 112, apackaging shell 113, alimiter 114 and an imagingoptical fiber bundle 115; wherein:

the fixedclamping groove 101 is arranged at the top end of thearmored shell 10;

thepositioning square groove 102 is positioned in thearmor shell 10;

the micro microscope objective group 111 is arranged at the foremost end of theoptical fiber sub-probe 11;

one end of thearmor 112 is connected with the micro objective lens group 111, and the other end is connected with thewrapping shell 113;

thestopper 114 is disposed on the surface of the wrappingcase 113 and is in a long strip shape.

Preferably, the multipole fiber micro-endoscopic probe further comprises animaging fiber bundle 115; wherein:

the imagingoptical fiber bundle 115 is located in theoptical fiber sub-probe 11 and is arranged behind the micro microscope objective group 111. The micro objective lens group 111 is mainly used to focus light inside the sample and collect the fluorescence excited by the sample into a single fiber of theimaging fiber bundle 115.

The numerical aperture of the micro objective lens group 111 in the image space is matched with the numerical aperture of the single optical fiber of the imagingoptical fiber bundle 115, that is, the numerical aperture of the micro objective lens group 111 at the end of the imagingoptical fiber bundle 115 is matched with the numerical aperture of the single optical fiber of the imagingoptical fiber bundle 115. The image pupil of the micro objective lens group 111 is at infinity, so that the light is coupled into each fiber of theimaging fiber bundle 115 with uniform fiber coupling efficiency.

Specifically, the positioning square groove is three long-strip square grooves with 120 degrees and is embedded in the armored shell.

Specifically, the depth of the positioning square groove is the same as the height of the stopper.

Specifically, the armor casing is cylindrical, and the material thereof is not particularly limited, and for example, the armor casing is made of medical stainless steel.

It should be noted that the implementation form of the micro objective lens group is not specifically limited, and the micro objective lens group is a combination of lens elements, and under the precondition of ensuring the image resolution, a better lens and processing assembly mode should be selected to reduce the external dimension thereof, so as to meet the actual requirements of living body imaging; of course, the packaging material is not particularly limited, and for example, a medical stainless steel package is used.

Specifically, the number of optical fibers of the imaging fiber bundle is not particularly limited and ultrafine imaging fibers are used.

Because of the adoption of the superfine imaging optical fiber bundle, the imaging optical fiber bundle can clinically enter a human body by utilizing a natural pipeline or percutaneous puncture of the human body, thereby achieving the purpose of early diagnosis of tumors and obviously reducing the discomfort of patients.

Specifically, the armor is a cylindrical shell constructed of a memory alloy and the memory alloy is fabricated into a 120 degree bend configuration that has been predetermined.

Specifically, the wrapping shell is made of medical stainless steel.

Fig. 3 is a schematic structural view of an extended fiber sub-probe of the multi-pole fiber-optic micro-endoscopic probe. In the above embodiment, during the operation, the doctor inserts the multi-electrode optical fiber micro-endoscopic probe into the position planned to be most likely to generate the residual tumor through percutaneous puncture, and then extends the threeoptical fiber sub-probes 11 which are originally contracted in thearmored shell 10, because the diameter of thearmored shell 10 is not limited, the necks of the threeoptical fiber sub-probes 11 restore the original set shape of the memory alloy, and orderly extend to three directions, so that the survival conditions of the residual tumor at multiple visual angles are observed, and the detection of different positions of the tumor is realized.

The invention discloses an optical microscopic detection device based on an optical fiber confocal microscopic imaging technology, and the optical microscopic detection device is shown in fig. 4 and is a structural schematic diagram of the optical microscopic detection device disclosed by the embodiment of the invention. The device comprises a multipolar optical fiber micro-endoscopic probe 1, an insertion tube 2, a host 3 and an electronic display screen 4. The insertion tube 2 can be a hard tube or a soft tube, an optical fiber tube or a signal wire is arranged in the insertion tube, the end of the insertion tube 2 is provided with the multi-electrode optical fiber micro-endoscopic probe 1, and the multi-electrode optical fiber micro-endoscopic probe 1 is generally cylindrical. The inside of the multipolar optical fiber micro-endoscopic probe 1 is configured into an optical lens or an electronic lens, when in use, the multipolar optical fiber micro-endoscopic probe 1 is inserted into cavity-shaped duct organs of a human body such as trachea, esophagus, anus and the like or is punctured into the human body through the inserting tube 2, the host 3 is provided with an electronic display screen 4 which is matched with the multipolar optical fiber micro-endoscopic probe 1 to work, the inside condition of the human body is observed through the multipolar optical fiber micro-endoscopic probe 1, and micron-scale high-resolution optical microscopic cell imaging is realized.

The optical microscopic detection device disclosed by the invention can work by combining a characteristic photon composite imaging technology, and in the treatment process, after the multi-pole optical fiber microscopic endoscopic probe enters a human body, the multi-point simultaneous detection can be carried out, the survival condition of the tumor can be observed from different visual angles, and the survival condition of the tumor can be accessed into a microscopic imaging processing system, so that the on-line optical microscopic imaging of the residual tumor cells can be realized. And then, the detected residual tumor cells are positioned and marked in a navigation map of characteristic photon composite imaging, so that the perfect combination of the scale imaging of the residual tumor cells and the scale imaging of the conventional tumor tissue, namely the microscopic and macroscopic imaging is realized, a doctor is guided to perform an ablation operation on line in real time, the treatment effect of the ablation operation is ensured, the tumor residues are avoided, the recurrence risk of the patient caused by the tumor residues or metastasis after the operation is reduced, and the integration of minimally invasive intervention diagnosis and treatment in the real sense is realized.

Claims (7)

1. A multi-pole optical fiber microscopic endoscopic probe is characterized in that: the optical fiber sub-probe comprises an armored shell and optical fiber sub-probes, wherein the armored shell internally comprises three optical fiber sub-probes; the armor shell includes: a fixed clamping groove and a positioning square groove; the fiber optic sub-probe comprises: the micro-objective lens group, the armor sleeve, the wrapping shell, the limiter and the imaging optical fiber bundle; wherein:

the fixed clamping groove is arranged at the top end of the armored shell;

the positioning square groove is positioned in the armor shell;

the micro microscope objective group is arranged at the foremost end of the optical fiber sub probe;

one end of the armor sleeve is connected with the micro objective lens group, and the other end of the armor sleeve is connected with the wrapping shell;

the limiting stopper is arranged on the surface of the wrapping shell and is in a long strip shape;

the multi-polar optical fiber micro-endoscopic probe also comprises an imaging optical fiber bundle; wherein:

the imaging optical fiber bundle is positioned in the optical fiber sub-probe and is arranged behind the micro microscope objective group.

2. The multipole optical fiber microscopic endoscopic probe of claim 1, wherein: the location square groove be three be 120 degrees rectangular square groove inlay in the inside of armor shell.

3. The multipole optical fiber microscopic endoscopic probe of claim 1, wherein: the depth of the positioning square groove is the same as the height of the limiting stopper.

4. The multipole optical fiber microscopic endoscopic probe of claim 1, wherein: the armor shell is cylindrical and is made of medical stainless steel.

5. The multipole optical fiber microscopic endoscopic probe of claim 1, wherein: the number of fibers of the imaging fiber bundle is not limited and an ultra-fine imaging fiber is used.

6. The multipole optical fiber microscopic endoscopic probe of claim 1, wherein: the armor is a cylindrical shell constructed of a memory alloy and the memory alloy is fabricated into a 120 degree bend configuration that has been predetermined.

7. The multipole optical fiber microscopic endoscopic probe of claim 1, wherein: the wrapping shell is made of medical stainless steel.

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