CN211584555U - A new type of blood/plasma perfusion device - Google Patents

Abstract

The utility model discloses a novel blood/plasma perfusion device, which comprises a shell, an upper end cover, an upper spiral cover, a lower spiral cover, an upper filtering device and a lower filtering device; the shell is provided with a liquid outlet end and a liquid inlet end, the inner diameter of the shell is gradually reduced from the liquid outlet end to the liquid inlet end, and the liquid inlet end is provided with a liquid inlet; a hollow cylindrical lower filtering device is arranged in the shell and is positioned at the liquid inlet end; an upper end cover is arranged at the liquid outlet end of the shell; the upper end cover is provided with a liquid outlet; an upper filtering device is arranged in the shell and is positioned at the liquid outlet end; the shell is filled with blood/plasma perfusion adsorbent. This perfusion ware overall structure is simple, and preparation and equipment are simple and easy, and the casing internal diameter is reduced gradually to the inlet end by the outlet end, and casing inlet end inboard is equipped with cylindric lower filter screen, can effectively avoid the cavity body to form in the use, effectively improves the validity that the adsorbent was clear away to the toxin.

Description

Translated fromChinese

一种新型血液/血浆灌流器A new type of blood/plasma perfusion device

技术领域technical field

本实用新型涉及医疗器械领域，具体是一种新型血液/血浆灌流器。The utility model relates to the field of medical devices, in particular to a novel blood/plasma perfusion device.

背景技术Background technique

血液/血浆灌流是通过借助体外循环，利用血液/血浆灌流器内具有特殊吸附功能的吸附树脂，特异性或非特异性清除患者血液中各种内源性或外源性毒物，达到改善机体内环境目的的一种血液净化技术。Blood/plasma perfusion is to use the adsorption resin with special adsorption function in the blood/plasma perfusion device to specifically or non-specifically remove various endogenous or exogenous toxins in the blood of patients through extracorporeal circulation, so as to improve the internal environment of the body. Purpose of a blood purification technology.

目前，血液/血浆灌流技术根据吸附树脂的不同，可以清除多种血液内毒素及病原物质，如尿酸、肌酐、胆红素、内毒素、炎性细胞因子、免疫球蛋白等，所治疗的疾病也从一般的药物中毒、肝肾疾病发展至免疫系统性疾病等多种疑难性疾病。随着高分子材料和免疫学的快速发展，血液灌流材料的发展也日新月异，血液/血浆灌流技术得到迅猛发展，临床应用越来越广泛。At present, blood/plasma perfusion technology can remove a variety of blood endotoxins and pathogenic substances, such as uric acid, creatinine, bilirubin, endotoxin, inflammatory cytokines, immunoglobulin, etc. It has also developed from general drug poisoning, liver and kidney diseases to immune system diseases and other difficult diseases. With the rapid development of polymer materials and immunology, the development of blood perfusion materials is also changing with each passing day.

传统血液/血浆灌流器由圆柱状柱体、上下端盖和容纳腔内的吸附剂组成。然而进行血液/血浆灌流治疗时，血液进入圆柱状柱体内部的吸附剂后，由于血液流速进入时较快，血液易与主体内中间部分树脂接触较充分，形成有效吸附，而四周吸附剂不易与血液接触，形成“空腔体”，但柱体中间部分吸附剂达到吸附平衡后，血液内有毒物质再流过时无法有效清除，柱体四周吸附剂无法发挥吸附有效性，从而导致治疗过程毒素吸附效率低，治疗效果有待进一步提高。The traditional blood/plasma perfusion device consists of a cylindrical cylinder, upper and lower end caps, and an adsorbent in the holding cavity. However, during blood/plasma perfusion therapy, after the blood enters the adsorbent inside the cylindrical column, the blood is likely to contact the resin in the middle part of the main body more fully due to the faster blood flow rate, and the effective adsorption is formed, while the surrounding adsorbent is not easy to Contact with blood to form a "cavity", but after the adsorbent in the middle part of the column reaches the adsorption equilibrium, the toxic substances in the blood cannot be effectively removed when it flows again, and the adsorbent around the column cannot exert its adsorption effectiveness, resulting in toxins during the treatment process. The adsorption efficiency is low, and the therapeutic effect needs to be further improved.

申请号201420653776.9的文献公开了一种血液灌流器，它对传统血液/血浆灌流器进行优化，将传统容纳腔内加设折流板，用于增加液体流程，折流板入液端与进液口连通，折流板出液端与出液口连接，改变容纳腔内血液流向增加吸附充分性，提高吸附效率，但未考虑血液在流动改变流向过程中，血细胞需承受与折流板的撞击力以及由于血液不断进入但不能及时流出而产生的挤压力，导致红细胞的溶血性增加，增加治疗风险。The document with the application number 201420653776.9 discloses a blood perfusion device, which optimizes the traditional blood/plasma perfusion device, and adds a baffle plate in the traditional accommodation cavity to increase the liquid flow. The liquid inlet end of the baffle plate and the liquid inlet The port is connected, and the liquid outlet end of the baffle is connected to the liquid outlet, changing the blood flow direction in the holding cavity to increase the adsorption adequacy and improve the adsorption efficiency, but it is not considered that the blood cells need to withstand the impact with the baffle during the process of changing the flow direction of the blood. The force and the squeezing force due to the continuous entry of blood but the inability to flow out in time lead to increased hemolysis of red blood cells and increase the risk of treatment.

实用新型内容Utility model content

针对现有技术的不足，本实用新型拟解决的技术问题是，提供一种新型血液/血浆灌流器。Aiming at the deficiencies of the prior art, the technical problem to be solved by the present invention is to provide a novel blood/plasma perfusion device.

本实用新型解决所述技术问题的技术方案是，提供一种新型血液/血浆灌流器，其特征在于该灌流器包括壳体、上端盖、上旋盖、下旋盖、上过滤装置和下过滤装置；所述壳体具有出液口端和进液口端，壳体内径由出液口端至进液口端逐渐减小，进液口端设置有进液口；壳体的内部设置有空心圆柱状的下过滤装置，位于进液口端处；壳体的出液口端设置有上端盖；上端盖设置有出液口；壳体的内部设置有上过滤装置，位于出液口端处；壳体内填充血液/血浆灌流吸附剂。The technical solution of the present invention to solve the technical problem is to provide a novel blood/plasma perfusion device, which is characterized in that the perfusion device comprises a casing, an upper end cap, an upper screw cap, a lower screw cap, an upper filter device and a lower filter The casing has a liquid outlet end and a liquid inlet end, the inner diameter of the casing gradually decreases from the liquid outlet end to the liquid inlet end, and the liquid inlet end is provided with a liquid inlet; the interior of the casing is provided with A hollow cylindrical lower filter device is located at the end of the liquid inlet; the liquid outlet end of the casing is provided with an upper end cover; place; the housing is filled with blood/plasma perfusion sorbent.

与现有技术相比，本实用新型有益效果在于：Compared with the prior art, the beneficial effects of the present utility model are:

(1)本灌流器壳体外侧为光滑弧面结构，壳体内径由出液口端到进液口端逐渐减小，形成类似圆锥状空腔结构，这样的结构设计通过对液体流向的作用，在灌流实施过程中可有效避免空腔体形成，提高液体与吸附剂的接触率，提高吸附效率。(1) The outer side of the casing of the perfusion device is a smooth arc structure, and the inner diameter of the casing gradually decreases from the liquid outlet end to the liquid inlet end, forming a similar conical cavity structure. This structural design affects the flow direction of the liquid. In the process of perfusion implementation, the formation of cavity can be effectively avoided, the contact rate between liquid and adsorbent can be improved, and the adsorption efficiency can be improved.

(2)上端盖为透明弧状结构，且出液口位于中央，便于在预冲过程中壳体内空气的排出，且透明上端盖的设计便于观察罐体内气体是否排尽。(2) The upper end cover is a transparent arc structure, and the liquid outlet is located in the center, which is convenient for the discharge of air in the shell during the pre-flushing process, and the design of the transparent upper end cover is convenient to observe whether the gas in the tank is exhausted.

(3)壳体进液口端内侧设有圆柱状的下过滤装置，液体由此端进入壳体后，进入过滤网过程无任何阻拦，可迅速充满过滤网，同时由于过滤网为柱状结构，液体在流速压力下可实现向四周有效分流，避免“空腔体”形成，显著提高毒素吸附效率。(3) There is a cylindrical lower filter device on the inner side of the liquid inlet end of the shell. After the liquid enters the shell from this end, there is no obstruction in the process of entering the filter screen, and the filter screen can be quickly filled. Under the flow pressure, the liquid can be effectively shunted to the surrounding, avoiding the formation of "cavity" and significantly improving the toxin adsorption efficiency.

(4)采用一次性注塑成型透明壳体，可避免由于连接不牢导致的产品泄露问题，且在灌流过程中便于观察灌流实施的顺畅性，若灌流器内发生异常可在第一时间采取补救措施。(4) The use of a one-time injection-molded transparent shell can avoid the problem of product leakage caused by poor connection, and it is convenient to observe the smoothness of the perfusion implementation during the perfusion process. If an abnormality occurs in the perfusion device, remedial measures can be taken at the first time. measure.

附图说明Description of drawings

图1为本实用新型一种实施例的整体结构示意图；1 is a schematic diagram of the overall structure of an embodiment of the present utility model;

图中：1、壳体；2、上端盖；3、上旋盖；4、下旋盖；5、上过滤装置；6、下过滤装置；7、出液口；8、进液口；9、血液/血浆灌流吸附剂。In the figure: 1. Shell; 2. Upper end cap; 3. Upper screw cap; 4. Lower screw cap; 5. Upper filter device; 6, Lower filter device; 7. Liquid outlet; 8. Liquid inlet; 9 , Blood/plasma perfusion adsorbent.

具体实施方式Detailed ways

下面结合实施例及附图对本实用新型作进一步说明。具体实施例仅用于进一步详细说明本实用新型，不限制本申请权利要求的保护范围。The present utility model will be further described below in conjunction with the embodiments and the accompanying drawings. The specific embodiments are only used to further describe the present invention in detail, and do not limit the protection scope of the claims of the present application.

本实用新型提供了一种新型血液/血浆灌流器(简称灌流器)，其特征在于该灌流器包括壳体1、上端盖2、上旋盖3、下旋盖4、上过滤装置5和下过滤装置6；所述壳体1为具有大开口出液口端和小开口进液口端的光滑透明弧形空腔圆台状结构，壳体内径由出液口端至进液口端逐渐减小，进液口端设置有进液口8，用于血液/血浆的进入；进液口8为医用鲁尔接头，并旋有下旋盖4；壳体1的内部设置有空心圆柱状的下过滤装置6，位于进液口端处；圆柱状下过滤装置6距离进液口8较近的底面不设置过滤网，另一个底面和侧面均设置有过滤网；壳体1的出液口端设置有弧状透明的上端盖2，透明便于观察壳体1内的气体是否排尽；上端盖2的中心设置有出液口7，便于灌流实施前壳体内空气的排出，避免壳体内空气排出不充分导致治疗过程中气栓的形成；出液口7为医用鲁尔接头，并旋有上旋盖3；壳体1的内部设置有上过滤装置5，位于出液口端处，防止血液/血浆灌流吸附剂9及吸附剂脱落的微小微粒流出，保证治疗安全性；壳体1内部为容纳腔，容纳腔内填充血液/血浆灌流吸附剂9。The utility model provides a novel blood/plasma perfusion device (referred to as perfusion device), which is characterized in that the perfusion device comprises a casing 1, anupper end cap 2, anupper screw cap 3, alower screw cap 4, anupper filter device 5 and a lower screw cap.Filter device 6; the shell 1 is a smooth and transparent arc-shaped cavity conical structure with a large opening liquid outlet end and a small opening liquid inlet end, and the inner diameter of the shell gradually decreases from the liquid outlet end to the liquid inlet end , the liquid inlet end is provided with aliquid inlet 8 for the entry of blood/plasma; theliquid inlet 8 is a medical Luer connector, and is screwed with alower screw cap 4; the interior of the housing 1 is provided with a hollow cylindrical lower Thefilter device 6 is located at the end of the liquid inlet; the bottom surface of the cylindricallower filter device 6 that is closer to theliquid inlet 8 is not provided with a filter screen, and the other bottom surface and the side are provided with a filter screen; the liquid outlet end of the shell 1 An arc-shaped transparentupper end cover 2 is provided, which is transparent and easy to observe whether the gas in the casing 1 is exhausted; the center of theupper end cover 2 is provided with aliquid outlet 7, which is convenient for the discharge of the air in the casing before the perfusion is carried out, and avoids the air in the casing from being exhausted. Fully lead to the formation of air embolism during the treatment process; theliquid outlet 7 is a medical Luer connector, and is screwed with anupper screw cap 3; the interior of the housing 1 is provided with anupper filter device 5, which is located at the liquid outlet end to prevent blood / The plasma perfusion adsorbent 9 and the tiny particles falling off the adsorbent flow out to ensure the safety of the treatment; the interior of the housing 1 is an accommodation cavity, and the accommodation cavity is filled with the blood/plasma perfusion adsorbent 9 .

优选地，上过滤装置5的过滤网和下过滤装置6的过滤网根据血液/血浆灌流吸附剂9种类的不同设置为50～200目，两者目数相同。Preferably, the filter screen of theupper filter device 5 and the filter screen of thelower filter device 6 are set to 50-200 meshes according to different types of the blood/plasma perfusion adsorbent 9, and the mesh numbers of the two are the same.

优选地，壳体从出液口端到进液口端依次由占壳体长度2/3～5/6的缓慢收口部分和占壳体长度1/6～1/3的大幅度弧状收口部分组成。Preferably, from the liquid outlet end to the liquid inlet end, the casing is sequentially composed of a slow closing portion occupying 2/3-5/6 of the length of the casing and a large arc-shaped closing portion occupying 1/6-1/3 of the length of the casing. composition.

优选地，下过滤装置6包括圆柱状支撑骨架和过滤网；所述支撑骨架为由两端圆形侧面支撑辐条构成的圆柱状结构，圆柱状支撑骨架的侧面和一个底面固定有过滤网，另一个距离进液口8较近的底面不设置过滤网且与进液口8连通。上过滤装置5为圆形片状过滤网。Preferably, thelower filter device 6 includes a cylindrical support frame and a filter screen; the support frame is a cylindrical structure composed of circular side support spokes at both ends, and a filter screen is fixed on a side surface and a bottom surface of the cylindrical support frame, and the other A bottom surface closer to theliquid inlet 8 is not provided with a filter screen and communicates with theliquid inlet 8 . Theupper filter device 5 is a circular sheet filter.

优选地，上端盖2、下过滤装置6和上过滤装置5均通过超声焊接固定于壳体1上。Preferably, theupper end cover 2 , thelower filter device 6 and theupper filter device 5 are all fixed on the casing 1 by ultrasonic welding.

优选地，上旋盖3和下旋盖4内均设置有密封垫，分别与出液口7和进液口8旋紧后，实现灌流器的密封。Preferably, both theupper screw cap 3 and thelower screw cap 4 are provided with sealing gaskets, which are screwed with theliquid outlet 7 and theliquid inlet 8 respectively to realize the sealing of the perfusion device.

优选地，上旋盖3和下旋盖4的圆周侧面均设置有防滑凸筋。Preferably, anti-skid ribs are provided on the circumferential sides of theupper screw cover 3 and thelower screw cover 4 .

优选地，血液/血浆灌流吸附剂9包括尿酸、肌酐、胆红素、内毒素、各种炎性细胞因子、免疫球蛋白等血液/血浆灌流治疗涉及的各种类型的吸附剂。Preferably, the blood/plasma perfusion adsorbent 9 includes various types of adsorbents involved in blood/plasma perfusion therapy, such as uric acid, creatinine, bilirubin, endotoxin, various inflammatory cytokines, and immunoglobulin.

本实用新型的工作原理和工作流程是：The working principle and workflow of the present utility model are:

将灌流器两端的出液口7和进液口8连接血液净化管路，建立体外循环通路；该灌流器竖直固定，进液口8位于下方，出液口7位于上方，实施体外预冲循环管路过程，液体由下至上逐渐通过灌流器，该过程中不断敲打壳体1，将其内部空气从出液口7排出。Theliquid outlet 7 and theliquid inlet 8 at both ends of the perfusion device are connected to the blood purification pipeline to establish an extracorporeal circulation path; the perfusion device is vertically fixed, theliquid inlet 8 is located below, and theliquid outlet 7 is located above, and extracorporeal pre-flushing is implemented. In the process of circulating the pipeline, the liquid gradually passes through the perfusion device from bottom to top. During this process, the shell 1 is continuously beaten to discharge the air inside it from theliquid outlet 7 .

预冲结束后，通过双腔插管与人体建立通路，实施灌流过程，血液进入进液口8后，迅速充满下过滤装置6，下过滤装置6将血液向四周分流，然后血液由下至上缓慢上升，减少“空腔体”形成，与血液/血浆灌流吸附剂9充分接触，显著提高毒素吸附效率。After the pre-flushing, a passageway is established with the human body through the double-lumen cannula, and the perfusion process is carried out. After the blood enters theliquid inlet 8, it quickly fills thelower filter device 6, and thelower filter device 6 shunts the blood around, and then the blood flows slowly from bottom to top. rise, reduce the formation of "cavity body", fully contact with the blood/plasma perfusion adsorbent 9, and significantly improve the toxin adsorption efficiency.

本实用新型未述及之处适用于现有技术。What is not mentioned in the present invention is applicable to the prior art.

Claims (10)

Translated fromChinese

1.一种新型血液/血浆灌流器，其特征在于该灌流器包括壳体、上端盖、上旋盖、下旋盖、上过滤装置和下过滤装置；所述壳体具有出液口端和进液口端，壳体内径由出液口端至进液口端逐渐减小，进液口端设置有进液口；壳体的内部设置有空心圆柱状的下过滤装置，位于进液口端处；壳体的出液口端设置有上端盖；上端盖设置有出液口；壳体的内部设置有上过滤装置，位于出液口端处；壳体内填充血液/血浆灌流吸附剂。1. A novel blood/plasma perfusion device, characterized in that the perfusion device comprises a housing, an upper end cap, an upper screw cap, a lower screw cap, an upper filter device and a lower filter device; the housing has a liquid outlet end and At the liquid inlet end, the inner diameter of the shell gradually decreases from the liquid outlet end to the liquid inlet end, and the liquid inlet end is provided with a liquid inlet; the interior of the shell is provided with a hollow cylindrical lower filter device, which is located at the liquid inlet The liquid outlet end of the casing is provided with an upper end cap; the upper end cap is provided with a liquid outlet; the interior of the casing is provided with an upper filter device located at the liquid outlet end; the casing is filled with blood/plasma perfusion adsorbent.2.根据权利要求1所述的新型血液/血浆灌流器，其特征在于所述壳体为具有大开口出液口端和小开口进液口端的弧面透明空腔圆台状结构。2 . The novel blood/plasma perfusion device according to claim 1 , characterized in that the shell is in the shape of an arcuate transparent cavity with a large open liquid outlet end and a small open liquid inlet end. 3 .3.根据权利要求1所述的新型血液/血浆灌流器，其特征在于壳体从出液口端到进液口端依次由占壳体长度2/3～5/6的缓慢收口部分和占壳体长度1/6～1/3的大幅度弧状收口部分组成。3. The novel blood/plasma perfusion device according to claim 1, characterized in that the shell is composed of a slow closing part and a slow closing part that occupies 2/3 to 5/6 of the length of the shell from the liquid outlet end to the liquid inlet end. It is composed of a large arc-shaped closing part with a length of 1/6 to 1/3 of the shell.4.根据权利要求1所述的新型血液/血浆灌流器，其特征在于上端盖为弧状且透明，出液口设置于上端盖的中心处。4 . The novel blood/plasma perfusion device according to claim 1 , wherein the upper end cap is arc-shaped and transparent, and the liquid outlet is arranged at the center of the upper end cap. 5 .5.根据权利要求1所述的新型血液/血浆灌流器，其特征在于上过滤装置为圆形片状过滤网。5. The novel blood/plasma perfusion device according to claim 1, characterized in that the upper filter device is a circular sheet filter.6.根据权利要求1所述的新型血液/血浆灌流器，其特征在于进液口为鲁尔接头，并旋有下旋盖；出液口为鲁尔接头，并旋有上旋盖。6 . The novel blood/plasma perfusion device according to claim 1 , wherein the liquid inlet is a Luer connector and is screwed with a lower screw cap; the liquid outlet is a Luer connector and screwed with an upper screw cap. 7 .7.根据权利要求1或6所述的新型血液/血浆灌流器，其特征在于上旋盖和下旋盖内均设置有密封垫。7. The novel blood/plasma perfusion device according to claim 1 or 6, characterized in that both the upper screw cap and the lower screw cap are provided with sealing gaskets.8.根据权利要求1或6所述的新型血液/血浆灌流器，其特征在于上旋盖和下旋盖的圆周侧面均设置有防滑凸筋。8. The novel blood/plasma perfusion device according to claim 1 or 6, characterized in that both the upper screw cap and the lower screw cap are provided with anti-skid ribs on the circumferential sides.9.根据权利要求1所述的新型血液/血浆灌流器，其特征在于下过滤装置包括圆柱状支撑骨架和过滤网；圆柱状支撑骨架的侧面和一个底面固定有过滤网，另一个距离进液口较近的底面不设置过滤网且与进液口连通。9. The novel blood/plasma perfusion device according to claim 1, characterized in that the lower filter device comprises a cylindrical support frame and a filter screen; The bottom surface near the port is not provided with a filter screen and communicates with the liquid inlet.10.根据权利要求1所述的新型血液/血浆灌流器，其特征在于上过滤装置的过滤网和下过滤装置的过滤网设置为50～200目。10 . The novel blood/plasma perfusion device according to claim 1 , wherein the filter screen of the upper filter device and the filter screen of the lower filter device are set to 50-200 meshes. 11 .

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