技术领域technical field
本实用新型涉及经颅磁刺激技术领域，特别涉及一种重复经颅磁刺激仪。The utility model relates to the technical field of transcranial magnetic stimulation, in particular to a repetitive transcranial magnetic stimulation instrument.
背景技术Background technique
经颅磁刺激技术(Transcranial Magnetic Stimulation，TMS)是生物医学和电磁学的交叉技术。生物体的生物组织和器官中因所含的微量元素和蛋白有顺磁性。在外界磁场的作用下生物体的组织细胞都能产生诱发电位，进而在生物体产生生理反应。而经颅磁刺激仪的刺激线圈就可作为这一外界的磁场的来源。Transcranial Magnetic Stimulation (TMS) is an interdisciplinary technology between biomedicine and electromagnetics. The biological tissues and organs of organisms have paramagnetic properties due to the trace elements and proteins contained in them. Under the action of an external magnetic field, the tissue cells of the organism can generate evoked potentials, and then produce physiological responses in the organism. The stimulating coil of the transcranial magnetic stimulator can be used as the source of this external magnetic field.
经颅磁刺激技术通过向生物体施加高强度变化电磁场从而达到刺激生物体组织或神经元的目的。主要依据Biot-Savart定律，通过变化的电流来产生变化的磁场，即在经颅磁刺激仪的线圈中施加变化的脉冲电流来产生变化的磁场。改变脉冲电流的脉冲频率和电流的大小来控制磁场的强弱和对生物组织的刺激时间。感应的变化磁场作用于人体组织后，会在人体组织中产生微弱的电流。这些微弱的电流到达一定强度后会导致神经元细胞兴奋或抑制，这个强度即为神经元的刺激阈值。刺激阈值是引起细胞动作电位的最小刺激幅度。低于这一幅度将不会使细胞产生动作电位，达不到刺激的目的。由于每个细胞的刺激阈值并不相同，刺激阈值只是一个统计值。在外界达到刺激的阈值后，这个刺激还必须持续一段时间才能达到刺激的效果。Transcranial magnetic stimulation technology achieves the purpose of stimulating biological tissues or neurons by applying high-intensity changing electromagnetic fields to the living body. Mainly according to the Biot-Savart law, a changing magnetic field is generated by a changing current, that is, a changing pulse current is applied to the coil of the transcranial magnetic stimulator to generate a changing magnetic field. Change the pulse frequency and current magnitude of the pulse current to control the strength of the magnetic field and the stimulation time to the biological tissue. After the induced changing magnetic field acts on the human tissue, a weak current will be generated in the human tissue. These weak currents will cause neurons to excite or inhibit after reaching a certain intensity, and this intensity is the stimulation threshold of neurons. Stimulation threshold is the minimum stimulus amplitude that elicits a cellular action potential. If it is lower than this range, the cells will not generate action potentials, and the purpose of stimulation will not be achieved. Since the stimulation threshold of each cell is not the same, the stimulation threshold is only a statistical value. After the outside world reaches the threshold of stimulation, the stimulation must continue for a period of time to achieve the stimulating effect.
在临床医学中，TMS作为一种无创的非侵入式的神经刺激技术，已获得广泛应用。其主要治疗的对象是运动系统的障碍患者，它通过刺激运动皮层，记录运动的诱发电位对病患目前的疾病状态做出有效的判断。抑郁症患者也是TMS主要治疗对象，抑郁症是一种精神类疾病，其主要临床表现为心境低落，部分病例会出现焦虑、幻想、妄想等症状。有研究表明抑郁症患者的大脑神经功能异常导致对积极情绪感知偏少，消极情绪偏多。TMS设备可以对特定的大脑神经元进行刺激来增强抑郁症患者对积极情绪的感知、减少消极情绪达到治疗目的。此外TMS设备在阿尔茨海默病的临床疾病诊断和治疗中都取得了良好的进展。能够连续进行多个脉冲刺激的TMS设备被称为重复经颅磁刺激(rTMS)设备。In clinical medicine, TMS has been widely used as a non-invasive and non-invasive nerve stimulation technology. Its main object of treatment is patients with motor system disorders. It can make an effective judgment on the current disease state of the patient by stimulating the motor cortex and recording the evoked potential of the movement. Depression patients are also the main treatment targets of TMS. Depression is a kind of mental illness. Its main clinical manifestation is low mood. In some cases, symptoms such as anxiety, fantasy, and delusion will appear. Studies have shown that the abnormal brain function of patients with depression leads to less perception of positive emotions and more negative emotions. TMS devices can stimulate specific brain neurons to enhance the perception of positive emotions in patients with depression and reduce negative emotions to achieve therapeutic purposes. In addition, TMS devices have made good progress in the clinical diagnosis and treatment of Alzheimer's disease. TMS devices capable of delivering multiple pulses of stimulation in succession are known as repetitive transcranial magnetic stimulation (rTMS) devices.
传统的rTMS设备由于包含控制单元，人机交互单元，高压直流电源单元，以及充放电单元和刺激线圈等部分。为了实现高强度的刺激磁场，需要在线圈内施加达到数千安培的时变电流。因此，由于内部包括大电流和高能量的电容器件等，需要保证其在使用中的电气安全性。因此，通常将整套设备整体封装在绝缘箱内，并设置较多的保护。这就导致目前的设备体积和重量较大。运输和搬运极为不便。需要2个以上成年男性并借助专用大型运输车辆和辅具才能进行移动。这限制了诸如在野外、战场和急救等多种场景下的使用。Traditional rTMS equipment includes a control unit, a human-computer interaction unit, a high-voltage DC power supply unit, a charging and discharging unit, and a stimulating coil. In order to achieve a high-intensity stimulating magnetic field, a time-varying current of thousands of amperes needs to be applied in the coil. Therefore, due to the large current and high energy capacitors inside, it is necessary to ensure its electrical safety in use. Therefore, the entire set of equipment is usually packaged in an insulating box, and more protection is provided. This results in the larger size and weight of current devices. Transportation and handling are extremely inconvenient. Two or more adult males are required to move with special large transport vehicles and assistive devices. This limits the use in various scenarios such as field, battlefield and first aid.
目前有一些小型化的磁刺激设备，通过缩小线圈尺寸和选用较小的充放电模块来减小整体重量。采用这样的方法已经出现了一些整体重量能够控制在5公斤以内的设备，可使用小型手提箱携带。并且在医师教育和小型动物和离体培养细胞的磁刺激过程中获得了应用。然而，这会导致线圈内的放电电流降低，感生磁场强度过低，不能对脑区产生阈上刺激。由于采用了较小的电容进行能量存储，也难以实现高密度的重复性刺激。所以这种技术方案多用于示范性教学或者对于细胞和小动物的实验中。并不适用于对于人脑等刺激。At present, there are some miniaturized magnetic stimulation devices, which reduce the overall weight by reducing the size of the coil and selecting a smaller charging and discharging module. Using this approach has produced some devices that can control the overall weight within 5 kg, and can be carried in a small suitcase. It has also found applications in physician education and magnetic stimulation of small animals and ex vivo cultured cells. However, this reduces the discharge current in the coil and the induced magnetic field strength is too low to produce suprathreshold stimulation of brain regions. Due to the use of smaller capacitors for energy storage, it is also difficult to achieve high-density repetitive stimulation. Therefore, this technical solution is mostly used in demonstration teaching or experiments on cells and small animals. Not suitable for stimuli such as the human brain.
实用新型内容Utility model content
本实用新型实施例提供了一种重复经颅磁刺激仪，用以在保证神经元刺激阈值的基础上，减小重复经颅磁刺激仪的体积和重量，保证电气安全性，且便于携带，该重复经颅磁刺激仪包括：The embodiment of the utility model provides a repetitive transcranial magnetic stimulator, which is used to reduce the volume and weight of the repetitive transcranial magnetic stimulator on the basis of ensuring the neuron stimulation threshold, ensure electrical safety, and is easy to carry. The repetitive transcranial magnetic stimulator includes:
刺激线圈装置，用于根据变化的脉冲电流产生变化的电磁场刺激神经元；A stimulating coil device for stimulating neurons by generating a varying electromagnetic field according to varying pulse currents;
第一箱体；所述第一箱体内设置有：储能电容，与所述刺激线圈装置连接，用于通过充放电将变化的脉冲电流传递至所述刺激线圈装置；A first box; the first box is provided with: an energy storage capacitor connected to the stimulating coil device, and used to transfer a changing pulse current to the stimulating coil device through charging and discharging;
第二箱体；所述第二箱体内设置有：充放电单元，与所述储能电容连接，用于改变所述储能电容的充放电时序；A second box; the second box is provided with: a charging and discharging unit connected to the energy storage capacitor and used to change the charging and discharging sequence of the energy storage capacitor;
第三箱体；所述第三箱体内设置有：主控单元，与所述充放电单元连接，用于控制所述充放电单元工作；高压直流电源，与所述主控单元和充放电单元连接，用于为所述主控单元和充放电单元供电。The third box; the third box is provided with: a main control unit connected to the charging and discharging unit for controlling the operation of the charging and discharging unit; a high-voltage DC power supply connected to the main control unit and the charging and discharging unit connected for supplying power to the main control unit and the charging and discharging unit.
与现有整箱式的重复经颅磁刺激仪相比较，本实用新型实施例提供的重复经颅磁刺激仪：Compared with the existing box-type repetitive transcranial magnetic stimulator, the repetitive transcranial magnetic stimulator provided by the embodiment of the utility model:
首先，将传统整体式重复经颅磁刺激仪改变成三个箱体：第一箱体、第二箱体和第三箱体，将重量和尺寸分摊给每个箱体，各单元相互隔离绝缘，因此，电气安全性高，且便于携带，无需借助专用大型运输车辆和辅具进行移动，适用于在野外、战场和急救等多种场景下使用。First of all, the traditional integral repetitive transcranial magnetic stimulator is changed into three boxes: the first box, the second box and the third box, and the weight and size are allocated to each box, and each unit is isolated from each other. , therefore, the electrical safety is high, and it is easy to carry, without the need for special large-scale transport vehicles and accessories to move, and is suitable for use in various scenarios such as field, battlefield, and first aid.
其次，通过充放电单元改变储能电容的充放电时序，实现间歇式的充电和放电过程，实现了用较小的线圈和储能电容，在保证阈上刺激强度的基础上，进一步加强了刺激脉冲的刺激频率，优化了设备的整体性能，因此，在保证神经元刺激阈值的基础上，减小重复经颅磁刺激仪的体积和重量。Secondly, by changing the charging and discharging sequence of the energy storage capacitor through the charging and discharging unit, the intermittent charging and discharging process is realized, and the use of smaller coils and energy storage capacitors is realized. On the basis of ensuring the stimulation intensity above the threshold, the stimulation is further strengthened. The stimulation frequency of the pulse optimizes the overall performance of the device. Therefore, on the basis of ensuring the neuron stimulation threshold, the volume and weight of the repetitive transcranial magnetic stimulator are reduced.
附图说明Description of drawings
此处所说明的附图用来提供对本实用新型的进一步理解，构成本申请的一部分，并不构成对本实用新型的限定。在附图中：The accompanying drawings described here are used to provide a further understanding of the utility model, constitute a part of the application, and do not constitute a limitation to the utility model. In the attached picture:
图1是现有整箱式重复经颅磁刺激仪的内部构造示意图；Figure 1 is a schematic diagram of the internal structure of an existing full-box repetitive transcranial magnetic stimulator;
图2是本实用新型实施例中重复经颅磁刺激仪的内部构造示意图；Fig. 2 is a schematic diagram of the internal structure of the repetitive transcranial magnetic stimulator in the embodiment of the present invention;
图3是本实用新型实施例中储能电容的充放电时序波形示意图；Fig. 3 is a schematic diagram of the charging and discharging sequence waveform of the energy storage capacitor in the embodiment of the utility model;
图4是本实用新型实施例中充放电单元及其连接部分示意图。Fig. 4 is a schematic diagram of the charging and discharging unit and its connection parts in the embodiment of the utility model.
具体实施方式Detailed ways
为使本实用新型的目的、技术方案和优点更加清楚明白，下面结合实施方式和附图，对本实用新型做进一步详细说明。在此，本实用新型的示意性实施方式及其说明用于解释本实用新型，但并不作为对本实用新型的限定。In order to make the purpose, technical solutions and advantages of the utility model clearer, the utility model will be further described in detail below in combination with the embodiments and accompanying drawings. Here, the exemplary implementation of the utility model and its description are used to explain the utility model, but not as a limitation to the utility model.
传统的重复经颅磁刺激(rTMS)设备的结构框图如图1所示。发明人经过长期大量的实验，对该设备经过仔细研究发现：可以根据其用途和电气风险等级进行归并，对重复经颅磁刺激(rTMS)设备进行改进，提出一种高场强便携式的重复经颅磁刺激仪，该刺激仪实现了在保证神经元刺激阈值的基础上，减小重复经颅磁刺激仪的体积和重量，电气安全性高，且便于携带，适用于在野外、战场和急救等多种场景下使用。该方案将不同的设备模块整合，改变传统的整体式的箱体，而采用轻便的绝缘军用旅行箱封装，可以实现便携和可移动的特点，同时，改变储能电容的充放电时序，实现间歇式的充电-放电过程，可以在使用较小电容的前提下，达到高重复频率的阈值上刺激。下面对该重复经颅磁刺激仪的结构进行详细介绍。The structural block diagram of traditional repetitive transcranial magnetic stimulation (rTMS) equipment is shown in Figure 1. After long-term and extensive experiments, the inventor has carefully studied the device and found that it can be combined according to its use and electrical risk level, and the repetitive transcranial magnetic stimulation (rTMS) device can be improved, and a high-field portable rTMS device is proposed. Cranial magnetic stimulator, the stimulator can reduce the volume and weight of repetitive transcranial magnetic stimulator on the basis of ensuring the neuron stimulation threshold. It has high electrical safety and is easy to carry. It is suitable for field, battlefield and first aid. It can be used in various scenarios. This solution integrates different equipment modules, changes the traditional integral box, and adopts a lightweight insulated military suitcase package, which can realize the characteristics of portability and mobility. At the same time, change the charging and discharging sequence of the energy storage capacitor to realize intermittent The charge-discharge process of the formula can achieve a high repetition frequency threshold stimulation under the premise of using a small capacitor. The structure of the repetitive transcranial magnetic stimulator will be introduced in detail below.
图2是本实用新型实施例中重复经颅磁刺激仪的内部构造示意图，如图2所示，该重复经颅磁刺激仪包括：Fig. 2 is a schematic diagram of the internal structure of the repetitive transcranial magnetic stimulator in the embodiment of the present invention. As shown in Fig. 2, the repetitive transcranial magnetic stimulator includes:
刺激线圈装置4，用于根据变化的脉冲电流产生变化的电磁场刺激神经元；The stimulating coil device 4 is used to generate a changing electromagnetic field to stimulate neurons according to the changing pulse current;
第一箱体1；所述第一箱体1内设置有：储能电容10，与所述刺激线圈装置连接，用于通过充放电将变化的脉冲电流传递至所述刺激线圈装置；The first box body 1; the first box body 1 is provided with: an energy storage capacitor 10, which is connected to the stimulation coil device, and is used to transfer a changing pulse current to the stimulation coil device through charging and discharging;
第二箱体2；所述第二箱体2内设置有：充放电单元20，与所述储能电容连接，用于改变所述储能电容的充放电时序；The second box body 2; the second box body 2 is provided with: a charging and discharging unit 20, connected to the energy storage capacitor, for changing the charging and discharging sequence of the energy storage capacitor;
第三箱体3；所述第三箱体3内设置有：主控单元30，与所述充放电单元连接，用于控制所述充放电单元工作；高压直流电源31，与所述主控单元30和充放电单元20连接，用于为所述主控单元和充放电单元供电。The third box body 3; the third box body 3 is provided with: a main control unit 30 connected to the charging and discharging unit for controlling the operation of the charging and discharging unit; a high-voltage DC power supply 31 connected to the main control unit The unit 30 is connected to the charging and discharging unit 20, and is used for supplying power to the main control unit and the charging and discharging unit.
与现有整箱式的重复经颅磁刺激仪相比较，本实用新型实施例提供的重复经颅磁刺激仪：Compared with the existing box-type repetitive transcranial magnetic stimulator, the repetitive transcranial magnetic stimulator provided by the embodiment of the utility model:
首先，将传统整体式重复经颅磁刺激仪改变成三个箱体：第一箱体、第二箱体和第三箱体，将重量和尺寸分摊给每个箱体，各单元相互隔离绝缘，因此，电气安全性高，且便于携带，无需借助专用大型运输车辆和辅具进行移动，适用于在野外、战场和急救等多种场景下使用。First of all, the traditional integral repetitive transcranial magnetic stimulator is changed into three boxes: the first box, the second box and the third box, and the weight and size are allocated to each box, and each unit is isolated from each other. , therefore, the electrical safety is high, and it is easy to carry, without the need for special large-scale transport vehicles and accessories to move, and is suitable for use in various scenarios such as field, battlefield, and first aid.
其次，通过充放电单元改变储能电容的充放电时序，实现间歇式的充电和放电过程，实现了用较小的线圈和储能电容，在保证阈上刺激强度的基础上，进一步加强了刺激脉冲的刺激频率，优化了设备的整体性能，因此，在保证神经元刺激阈值的基础上，减小重复经颅磁刺激仪的体积和重量。Secondly, by changing the charging and discharging sequence of the energy storage capacitor through the charging and discharging unit, the intermittent charging and discharging process is realized, and the use of smaller coils and energy storage capacitors is realized. On the basis of ensuring the stimulation intensity above the threshold, the stimulation is further strengthened. The stimulation frequency of the pulse optimizes the overall performance of the device. Therefore, on the basis of ensuring the neuron stimulation threshold, the volume and weight of the repetitive transcranial magnetic stimulator are reduced.
在一实施例中，如图4所示，充放电单元包括：充电电路和放电电路；其中，充电电路包括：In one embodiment, as shown in FIG. 4, the charging and discharging unit includes: a charging circuit and a discharging circuit; wherein, the charging circuit includes:
充电输入端P11，与高压直流电源31的输出端连接，用于接收高压直流电源31输出的电流电压；The charging input terminal P11 is connected to the output terminal of the high-voltage DC power supply 31, and is used to receive the current and voltage output by the high-voltage DC power supply 31;
限流电阻R14，限流电阻R14的第一端与所述充电输入端连接，第二端与储能电容(正极端)连接，用于将所述电流电压进行限流保护后提供给储能电容C8，给储能电容C8充电；Current-limiting resistor R14, the first end of the current-limiting resistor R14 is connected to the charging input end, and the second end is connected to the energy storage capacitor (positive end), which is used to provide the current and voltage to the energy storage after performing current-limiting protection Capacitor C8 charges the energy storage capacitor C8;
所述放电电路包括：The discharge circuit includes:
第一晶闸管DB2，第一晶闸管DB2的阴极与刺激线圈装置4中的线圈L1连接，第一晶闸管DB2的阳极与储能电容C8连接，第一晶闸管DB2的控制极与控制板触发信号芯片P9连接；控制板为所述主控单元；The first thyristor DB2, the cathode of the first thyristor DB2 is connected to the coil L1 in the stimulating coil device 4, the anode of the first thyristor DB2 is connected to the energy storage capacitor C8, and the control pole of the first thyristor DB2 is connected to the trigger signal chip P9 of the control board ; The control board is the main control unit;
二极管D4，二极管D4的阳极与第一晶闸管DB2的阴极、刺激线圈装置4中的线圈L1连接，二极管D4的阴极与储能电容、第一晶闸管DB2的阳极连接。A diode D4, the anode of the diode D4 is connected to the cathode of the first thyristor DB2 and the coil L1 in the stimulating coil device 4, the cathode of the diode D4 is connected to the energy storage capacitor and the anode of the first thyristor DB2.
具体实施时，充放电单元结构可以如图4中的电路所示。在充放电单元中，充电部分是电容经过保护电阻(R14)以一定电流不停的向储能电容C8充电，放电部分原理类似典型RLC谐振电路。在实际使用中还要保证刺激电流的及时关断，防止拖尾现象的产生。所以实际充放电电路(充放电单元)原理图如图4所示。During specific implementation, the structure of the charging and discharging unit may be as shown in the circuit in FIG. 4 . In the charging and discharging unit, the charging part is that the capacitor continuously charges the energy storage capacitor C8 with a certain current through the protection resistor (R14), and the principle of the discharging part is similar to a typical RLC resonant circuit. In actual use, it is also necessary to ensure that the stimulating current is turned off in time to prevent the occurrence of tailing. Therefore, the schematic diagram of the actual charging and discharging circuit (charging and discharging unit) is shown in Figure 4.
如图4所示，该电路是大容量电容的充放电电路，输入端P11与高压直流电源31的输出端连接，该输入端P11接入电源是高压直流电源模块(高压直流电源31)。该高压直流电源31对外接口主要有三部分，输入电压接口、输出电压接口、控制电路(主控单元30)接口。其中，输入电压接口接0-220V的交流电；输出电压接口输出的是一个0-2000V最大电流1A的输出电流电压可控制的大功率稳压电源；控制接口部分提供的一个DB15的15针接口作为控制部分与控制单元(主控单元30)相连接。其中，控制单元(主控单元30)通过TPL0401A/B两个集成芯片输出0到5V的模拟量，从而控制高压电源(高压直流电源31)输出的电压和电流值的大小。高压电源(高压直流电源31)受控后输出的稳压电源在通过20欧姆的限流电阻R14(保护电阻)后对储能电容(例如图4中的C8)进行充电。当检测到电容两端电压到达设定值时，高压电源(高压直流电源31)停止充电。当可控硅DB2没有导通时，后端的放电线圈L1中是没有电流的。当控制电路(主控单元)给晶闸管DB2触发信号时，DB2导通，高压电容(储能电容C8)开始放电，放电回路(放电电路)等效是RLC谐振电路，放电回路中产生时变的电流，时变电流在放电线圈L1内产生时变的磁场作用于生物组织。如图3所示，时变的电流的时间幅值的图形是一个振荡衰减的类正弦波，当在电流处在正弦波的正半周期时，线圈中的电流方向是顺时针方向，当电流进入负半周期时由大功率二级管D4进行续流，电流反向电流方向为逆时针方向，产生第二个刺激脉冲。在这个周期当中DB2由于电流反向，DB2立即关断。当电流在逆时针方向中从0到波峰再到0时，由于DB2已经关断所有电路中没有回路，RLC谐振振荡电路在经过一个波峰和一个波谷后，RLC放电回路马上被关断。最后形成的刺激脉宽即为双脉宽刺激波形。As shown in FIG. 4 , the circuit is a charging and discharging circuit for a large-capacity capacitor. The input terminal P11 is connected to the output terminal of the high-voltage DC power supply 31 . The input terminal P11 is connected to a high-voltage DC power supply module (high-voltage DC power supply 31 ). The external interface of the high-voltage DC power supply 31 mainly has three parts, an input voltage interface, an output voltage interface, and a control circuit (main control unit 30 ) interface. Among them, the input voltage interface is connected to 0-220V AC; the output voltage interface outputs a 0-2000V maximum current 1A output current and voltage controllable high-power regulated power supply; the control interface part provides a 15-pin interface of DB15 as The control section is connected with a control unit (main control unit 30). Among them, the control unit (main control unit 30 ) outputs an analog quantity from 0 to 5V through two integrated chips TPL0401A/B, thereby controlling the voltage and current value output by the high-voltage power supply (high-voltage DC power supply 31 ). After the high-voltage power supply (high-voltage DC power supply 31 ) is controlled, the output regulated power supply charges the energy storage capacitor (such as C8 in FIG. 4 ) after passing through the 20-ohm current-limiting resistor R14 (protective resistor). When it is detected that the voltage at both ends of the capacitor reaches the set value, the high-voltage power supply (high-voltage DC power supply 31) stops charging. When the thyristor DB2 is not turned on, there is no current in the discharge coil L1 at the rear end. When the control circuit (main control unit) sends a trigger signal to the thyristor DB2, DB2 is turned on, and the high-voltage capacitor (energy storage capacitor C8) starts to discharge. The discharge circuit (discharge circuit) is equivalent to an RLC resonant circuit, and a time-varying current is generated in the discharge circuit. Current, the time-varying current generates a time-varying magnetic field in the discharge coil L1 to act on the biological tissue. As shown in Figure 3, the graph of the time amplitude of the time-varying current is an oscillating attenuation-like sine wave. When the current is in the positive half cycle of the sine wave, the direction of the current in the coil is clockwise. When the current When entering the negative half cycle, the high-power diode D4 carries out freewheeling, and the reverse current direction of the current is counterclockwise, generating the second stimulation pulse. During this cycle, DB2 is turned off immediately due to the reverse current. When the current goes from 0 to the peak and then to 0 in the counterclockwise direction, since DB2 has been turned off and there is no loop in all circuits, after the RLC resonant oscillation circuit passes through a peak and a valley, the RLC discharge loop is immediately turned off. The final stimulation pulse width is the double pulse width stimulation waveform.
在一实施例中，如图4所示，充放电单元还可以包括：安全保护电路，该安全保护电路可以包括：In an embodiment, as shown in FIG. 4, the charging and discharging unit may further include: a safety protection circuit, and the safety protection circuit may include:
残电吸收电阻R15，第一端与限流电阻R14的第二端、储能电容C8的第一端(正极端)连接；The residual current absorbing resistor R15, the first end is connected with the second end of the current limiting resistor R14 and the first end (positive end) of the energy storage capacitor C8;
第二晶闸管DB3，第二晶闸管DB3的阴极与储能电容C8(第二端，负极端)连接，第二晶闸管DB3的阳极与残电吸收电阻R15的第二端连接，第二晶闸管DB3的控制极与控制板触发信号芯片P10连接；控制板为所述主控单元。The second thyristor DB3, the cathode of the second thyristor DB3 is connected to the energy storage capacitor C8 (the second end, the negative terminal), the anode of the second thyristor DB3 is connected to the second end of the residual current absorbing resistor R15, the control of the second thyristor DB3 The pole is connected with the trigger signal chip P10 of the control board; the control board is the main control unit.
具体实施时，当设备使用结束后，储能电容C8中或有电量残留，为保证安全，在停止充放电回路运行后，需手动(此时P11为手动开关)或者以主控单元30(此时P11为释放残留电量的控制信号接收端)控制打开第二晶闸管DB3，使电容通过残电吸收电阻R15将残留电量释放干净。During specific implementation, after the device is used, there may be residual electricity in the energy storage capacitor C8. To ensure safety, after stopping the operation of the charging and discharging circuit, it is necessary to manually (at this time, P11 is a manual switch) or use the main control unit 30 (here When P11 is the control signal receiving end for releasing the residual power), the second thyristor DB3 is controlled to be turned on, so that the capacitor can completely discharge the residual power through the residual power absorbing resistor R15.
具体实施时，刺激线圈装置4可以为刺激线圈手柄，其内部的刺激线圈与储能电容连接。主控单元30还可以控制高压直流电源31工作。各个箱体内的单元可以通过有线连接，当然也可以通过无线通信连接。During specific implementation, the stimulating coil device 4 may be a stimulating coil handle, and the stimulating coil inside it is connected to the energy storage capacitor. The main control unit 30 can also control the high voltage DC power supply 31 to work. The units in each cabinet can be connected by wires, and of course they can also be connected by wireless communication.
在一个实例中，所述第一箱体、第二箱体和第三箱体可以为绝缘军用旅行箱。In one example, the first case, the second case and the third case may be insulated military suitcases.
具体实施时，第一箱体、第二箱体和第三箱体可以为绝缘军用旅行箱，可以保证电气安全性，以及便于携带。During specific implementation, the first box body, the second box body and the third box body can be insulated military suitcases, which can ensure electrical safety and are easy to carry.
发明人经过长期的大量实验研究，提出了如下刺激线圈和三个箱体的尺寸方案，以及储能电容的容量方案。After a long period of extensive experimental research, the inventor proposed the following schemes for the dimensions of the stimulation coil and the three boxes, and the scheme for the capacity of the energy storage capacitor.
在一个实例中，所述刺激线圈装置中刺激线圈内径的尺寸取值范围可以为：小于6厘米(cm)，外径的尺寸与内径的尺寸之差的取值范围可以为：大于1厘米。In one example, the range of the inner diameter of the stimulating coil in the stimulating coil device may be less than 6 centimeters (cm), and the range of the difference between the outer diameter and the inner diameter may be greater than 1 cm.
具体实施时，在刺激线圈内径的尺寸取值范围小于6厘米，外径的尺寸与内径的尺寸之差的取值范围大于1厘米时，实现了在保证神经元刺激阈值的基础上，减小重复经颅磁刺激仪的体积和重量。进一步地，刺激线圈内径的尺寸取值范围为小于6厘米(cm)，外径的尺寸与内径的尺寸之差的取值范围为大于1.5厘米，这样的方案也可以进一步实现了在保证神经元刺激阈值的基础上，减小重复经颅磁刺激仪的体积和重量。During specific implementation, when the value range of the inner diameter of the stimulating coil is less than 6 cm, and the value range of the difference between the size of the outer diameter and the inner diameter is greater than 1 cm, it is realized on the basis of ensuring the neuron stimulation threshold. Repeat for the volume and weight of the transcranial magnetic stimulator. Further, the size range of the inner diameter of the stimulating coil is less than 6 centimeters (cm), and the range of the difference between the size of the outer diameter and the size of the inner diameter is greater than 1.5 cm. Such a scheme can also be further realized while ensuring that neurons Based on the stimulation threshold, reduce the volume and weight of the repetitive transcranial magnetic stimulator.
在一个实例中，所述刺激线圈装置中刺激线圈内径的尺寸取值可以为5.5厘米，外径的尺寸与内径的尺寸之差的取值可以为1.5厘米。In an example, the inner diameter of the stimulating coil in the stimulating coil device may be 5.5 cm, and the difference between the outer diameter and inner diameter may be 1.5 cm.
具体实施时，刺激线圈内径的尺寸取值为5.5厘米，外径的尺寸与内径的尺寸之差的取值范围为1.5厘米，进一步实现了在保证神经元刺激阈值的基础上，减小重复经颅磁刺激仪的体积和重量。进一步地，刺激线圈内径的尺寸取值为2厘米，外径的尺寸与内径的尺寸之差的取值范围为1.6厘米，这样的方案也可以进一步实现了在保证神经元刺激阈值的基础上，减小重复经颅磁刺激仪的体积和重量。During specific implementation, the size of the inner diameter of the stimulation coil is 5.5 cm, and the range of the difference between the size of the outer diameter and the size of the inner diameter is 1.5 cm, which further realizes that on the basis of ensuring the neuron stimulation threshold, the reduction of repeated The volume and weight of the magnetic stimulator. Further, the size of the inner diameter of the stimulation coil is 2 cm, and the range of the difference between the size of the outer diameter and the size of the inner diameter is 1.6 cm. Such a scheme can also be further realized. On the basis of ensuring the neuron stimulation threshold, Reduce the size and weight of repetitive transcranial magnetic stimulators.
在一个实例中，所述储能电容的容量范围可以为大于75微法(μF)，储能电容两端的电压取值范围可以为大于1500伏(V)。In an example, the capacity range of the energy storage capacitor may be greater than 75 microfarads (μF), and the range of the voltage across the energy storage capacitor may be greater than 1500 volts (V).
具体实施时，储能电容的容量范围为大于75微法(μF)，储能电容两端的电压取值范围为大于1500伏(V)时，实现了在保证神经元刺激阈值的基础上，减小重复经颅磁刺激仪的体积和重量。During specific implementation, the capacity range of the energy storage capacitor is greater than 75 microfarads (μF), and when the voltage value range at both ends of the energy storage capacitor is greater than 1500 volts (V), on the basis of ensuring the neuron stimulation threshold, reducing Small size and weight for repetitive transcranial magnetic stimulators.
在一个实例中，所述储能电容的容量可以为150μF，储能电容两端的电压取值可以为2000V。In an example, the capacity of the energy storage capacitor may be 150 μF, and the voltage across the energy storage capacitor may be 2000V.
具体实施时，储能电容的容量为150μF，储能电容两端的电压取值范围为2000V时，进一步实现了在保证神经元刺激阈值的基础上，减小重复经颅磁刺激仪的体积和重量。进一步地，储能电容的容量为150μF，储能电容两端的电压取值范围为3000V时，进一步实现了在保证神经元刺激阈值的基础上，减小重复经颅磁刺激仪的体积和重量。In the specific implementation, the capacity of the energy storage capacitor is 150μF, and when the voltage range of the two ends of the energy storage capacitor is 2000V, it is further realized that the volume and weight of the repetitive transcranial magnetic stimulator can be reduced on the basis of ensuring the neuron stimulation threshold. . Furthermore, when the capacity of the energy storage capacitor is 150 μF, and the voltage range across the energy storage capacitor is 3000V, the volume and weight of the repetitive transcranial magnetic stimulator are further reduced on the basis of ensuring the neuron stimulation threshold.
在一个实例中，所述第一箱体的尺寸取值范围可以为小于100*100*100cm；In an example, the size range of the first box may be less than 100*100*100cm;
所述第二箱体的尺寸取值范围可以为小于100*100*100cm；The size range of the second box can be less than 100*100*100cm;
所述第三箱体的尺寸取值范围可以为小于100*100*100cm。The size range of the third box may be less than 100*100*100cm.
具体实施时，第一箱体的尺寸为：66.7*43*25cm，所述第二箱体的尺寸为47*25*35cm，所述第三箱体的尺寸为45*38*25cm，便于携带，适用于在野外、战场和急救等多种场景下使用。During specific implementation, the size of the first box is: 66.7*43*25cm, the size of the second box is 47*25*35cm, and the size of the third box is 45*38*25cm, which is easy to carry , suitable for use in various scenarios such as the field, battlefield and first aid.
在一个实例中，所述高压直流电源设置在一高压电源箱内，所述高压电源箱设置在所述第三箱体内。In one example, the high-voltage direct current power supply is arranged in a high-voltage power supply box, and the high-voltage power supply box is arranged in the third box.
具体实施时，设置高压电源箱，进一步保证了电气的安全性。During specific implementation, a high-voltage power supply box is provided to further ensure electrical safety.
在一个实例中，所述充放电单元具体为单片机或PLC控制单元。In one example, the charging and discharging unit is specifically a single-chip microcomputer or a PLC control unit.
在一个实例中，上述重复经颅磁刺激仪还包括：人机交互单元，设置在所述第三箱体的表面，与所述主控单元连接，用于接收用户的控制指令，或显示脉冲电流大小、电磁场大小和刺激阈值。In one example, the repetitive transcranial magnetic stimulator further includes: a human-computer interaction unit, arranged on the surface of the third box, connected to the main control unit, and used to receive the user's control instructions, or display the pulse Current magnitude, electromagnetic field magnitude and stimulation threshold.
具体实施时，人机交互单元的设置方便重复经颅磁刺激仪的使用，灵活性高。During specific implementation, the setting of the human-computer interaction unit is convenient for repeating the use of the transcranial magnetic stimulator, and the flexibility is high.
本实用新型实施例实现了如下技术效果：The utility model embodiment has realized following technical effect:
本实用新型提供的技术方案通过将一个整体化的TMS设备，根据模块拆解成多个分立的箱体内。最大的箱体不超过40kg千克，最大尺寸不超过70*50*50cm，能够实现两个以内的成年人不借助其他工具搬动。三个箱子，将所需的最大尺寸长度减小，可使用普通四座载客汽车运送，而不需要专用的大型汽车运送。增强了移动性，便于在野外环境、战时和救灾等场景下的设备投送。The technical solution provided by the utility model disassembles an integrated TMS device into a plurality of separate boxes according to the modules. The largest box does not exceed 40kg, and the maximum size does not exceed 70*50*50cm, which can be moved by less than two adults without using other tools. Three boxes, reducing the required maximum size and length, can be transported by ordinary four-seater passenger vehicles, without the need for dedicated large vehicles. Enhanced mobility facilitates delivery of equipment in scenarios such as field environments, wartime and disaster relief.
同时，该设备主要利用充放电的时序优化，在保证阈上刺激强度的基础上，进一步加强了刺激脉冲的刺激频率，优化了设备的整体性能。At the same time, the device mainly utilizes the timing optimization of charge and discharge to further strengthen the stimulation frequency of the stimulation pulse on the basis of ensuring the suprathreshold stimulation intensity, and optimize the overall performance of the device.
以上所述仅为本实用新型的优选实施例而已，并不用于限制本实用新型，对于本领域的技术人员来说，本实用新型实施例可以有各种更改和变化。凡在本实用新型的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本实用新型的保护范围之内。The above descriptions are only preferred embodiments of the present utility model, and are not intended to limit the present utility model. For those skilled in the art, various modifications and changes may be made to the embodiments of the present utility model. Any modification, equivalent replacement, improvement, etc. made within the spirit and principles of the present utility model shall be included in the protection scope of the present utility model.
| Application Number | Priority Date | Filing Date | Title |
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| CN201821950880.9UCN209696073U (en) | 2018-11-26 | 2018-11-26 | Repetitive Transcranial Magnetic Stimulator |
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| CN201821950880.9UCN209696073U (en) | 2018-11-26 | 2018-11-26 | Repetitive Transcranial Magnetic Stimulator |
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| CN111857231A (en)* | 2020-07-14 | 2020-10-30 | 中国科学院电工研究所 | A device and method for controlling a rotating magnetic field using a capacitor charging and discharging sequence |
| CN115282488A (en)* | 2022-06-21 | 2022-11-04 | 中国科学院自动化研究所 | Magnetic stimulation instrument |
| CN115282488B (en)* | 2022-06-21 | 2023-09-12 | 中国科学院自动化研究所 | a magnetic stimulator |
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