Specific embodiment
In the following detailed description, it has references to and constitutes a part following detailed description of and diagrammatically show canTo implement the attached drawing of specific embodiment of the present utility model.To also referred herein as " example " these embodiments intoRow describes in detail enough, so that those skilled in the art can implement the utility model, and it will be appreciated that each realityThe mode of applying can be combined, or can use other embodiments, and in the feelings for not departing from the scope of the utility modelStructure change, logic variation and Electrical change can be made under condition.Therefore, described in detail below not managed with restrictive senseSolution, and the scope of the utility model is limited by appended claims and its equivalent.
Fig. 1 shows exemplary radiation therapy system 100, which is used for patient, patient body" manikin " of the target object of a part that is a part of or may include expression patient or patient body provides radiation and controlsIt treats.Radiotherapy system 100 includes image processing apparatus 112.Image processing apparatus 112 can connect to network 120.Network120 can connect to internet 122.Network 120 can be by image processing apparatus 112 and database 124, hospital database126, oncology information system (OIS) 128, radiotherapy unit 130, image acquiring device 132, display device 134 and useOne of family interface 136 or more person connection.Image processing apparatus 112 can be configured to generate to by radiotherapy unit130 radiotherapeutic treatment plans 142 used.
Image processing apparatus 112 may include memory device 116, processor 114 and communication interface 118.Memory deviceSetting 116 can store computer executable instructions, for example operating system 143, radiotherapeutic treatment plan 142 are (for example, initialTreatment plan, treatment plan of adjustment etc.), software program 144 (for example, artificial intelligence, deep learning, neural network, radiation treatMethod therapy plot software) and any other computer executable instructions to be executed by processor 114.In an embodiment partyIn formula, software program 144 can by generate composograph --- such as puppet CT image --- by a kind of format (for example,MRI medical image) is converted to the medical image of another format (for example, CT).For example, software program 144 may include toThe image processing program of training prediction model, the prediction model are used for a kind of 146 (example of medical image of form (modality)Such as, MRI image) be converted to the composograph (for example, puppet CT image) to take a different form, alternatively, the prediction mould being trained toCT image can be converted into MRI image by type.In another embodiment, software program 144 can be distributed with the dosage of patient(also being indicated as image) Lai Jilu patient image (for example, CT image or MR image), so that corresponding image voxel and dosage bodyElement is suitably associated by network.In yet another embodiment, software program 144 can replace the function of patient image, thanAs tape symbol distance function or emphasize image information some in terms of image processed version.This function may be strongAdjust the edge in terms of voxel texture or difference or any other configuration aspects useful to neural network learning edge orDifference.In another embodiment, the dosage in terms of software program 144 can replace some for emphasizing dosage information is distributed letterNumber.This function may emphasize steep gradient around target or any other configuration aspects useful to neural network learningSteep gradient.Memory device 116 can store following data: the data include medical image 146, patient data 145 andOther are to data needed for establishing and implementing radiotherapeutic treatment plan 142.
Other than the memory 116 of storage software program 144, it is contemplated that software program 144 can be storedOn movable computer medium, the movable computer medium be such as hard disk drive, computer disk, CD-ROM,DVD, HD, blue-ray DVD, USB flash drive, SD card, memory stick or any other suitable medium, and software program 144It can be executed by image processor 114 when being downloaded on image processing apparatus 112.
Processor 114 can be communicatively coupled to memory device 116, and processor 114 can be configured to execute and depositIt is stored in computer executable instructions thereon.Medical image 146 can be sent or received memory 116 by processor 114.For example, processor 114 can via communication interface 118 and network 120 from image acquiring device 132 receive medical image 146 withIt is stored in memory 116.Processor 114 can also be stored in memory 116 to the transmission of network 120 via communication interface 118In medical image 146, medical image 146 is stored in database 124 or hospital database 126.
In addition, processor 114 can use software program 144 (for example, therapy plot software) together with 146 He of medical imagePatient data 145 is together to establish radiotherapeutic treatment plan 142.Medical image 146 may include such as with patient anatomical areaThe information of domain, organ or the interested volume segmentation associated imaging data of data etc.Under patient data 145 may includeState information: the information is such as (1) functional organ's modeling data (for example, serial organ and parallel organ, dosage appropriateResponse model etc.), (2) dose of radiation data (for example, dose volume histogram (DVH) information) or (3) and patient and treatmentOther related clinical information (for example, other surgical operations, chemotherapy, previous radiotherapy etc.) of the course for the treatment of.
In addition, processor 114 can use software program to generate intermediate data --- such as example to by nerve netNetwork model come using undated parameter --- or generate intermediate 2D image or 3D rendering, the intermediate 2D image or 3D rendering are thenIt can be subsequently stored in memory 116.Processor 114 can then pass through executable radiotherapeutic treatment plan 142Network 120 is transmitted to by communication interface 118 and then is transmitted to radiotherapy unit 130, in the radiotherapy unit 130, is putTreatment plan is penetrated for treating patient by radiating.In addition, processor 114 can execute software program 144, to realize such asThe function of image conversion, image segmentation, deep learning, neural network and artificial intelligence etc.For example, processor 114 can be withIt executes training of medical image or delineates the software program 144 of the profile of medical image, this software 144 can instruct when executedPractice edge detector or utilizes shape dictionary.
Processor 114 can be include one or more general processing units processing unit, the general procedureDevice is such as microprocessor, central processing unit (CPU), graphics processing unit (GPU), acceleration processing unit (APU) etc..MoreSpecifically, processor 114 can be complex instruction set calculation (CISC) microprocessor, reduced instruction set computing (RISC) micro processDevice, very long instruction word (VLIW) microprocessor, the processor for executing other instruction set or the processor for executing combined command collection.Processor 114 can also be realized that the special processor is such as dedicated collection by one or more special processorsAt circuit (ASIC), field programmable gate array (FPGA), digital signal processor (DSP), system level chip (SoC) etc..Such asBy what is be appreciated by those skilled in the art, in some embodiments, processor 114 can be application specific processor rather than generalProcessor.Processor 114 may include one or more well known processing units, for example carry out free IntelTMManufacturedPentiumTM、CoreTM、XeonTMOrThe microprocessor of series；By AMDTMManufactured TurionTM、AthlonTM、SempronTM、 OpteronTM、FXTM、PhenomTMThe microprocessor of series；Or by Sun MicrosystemsAny one of various processors manufactured by (Sun Microsystems) microprocessor.Processor 114 can also includeGraphics processing unit, for example carry out free NvidiaTMManufacturedSeriesGPU；By IntelTMManufactured GMA, IrisTMThe GPU of series；Or by AMDTMManufactured RadeonTMThe GPU of series.PlaceManaging device 114 can also include acceleration processing unit, such as by IntelTMManufactured Xeon PhiTMThe acceleration of series handles singleMember.Disclosed embodiment is not limited to the satisfaction identification being otherwise configured to, analysis, maintenance, the calculating need generatedIt seeks and/or provides mass data or this data are manipulated to execute any class of method disclosed hereinThe processor of type.In addition, term " processor " may include more than one processor, for example, multicore design or respective with moreMultiple processors of core design.Processor 114 can execute the sequences of computer program instructions being stored in memory 116,To execute the various operations being described in more detail below, process, method.
Memory device 116 can store medical image 146.In some embodiments, medical image 146 may includeOne or more MRI images are (for example, 2D MRI, 3D MRI, 2D streaming MRI, 4D MRI, 4D volume MRI, 4D cinema MR IDeng), functional MRI image (for example, fMRI, DCE-MRI, diffusion MR I), computed tomography (CT) image is (for example, 2DCT, conical beam CT, 3D CT, 4D CT), ultrasound image (for example, 2D is ultrasonic, 3D ultrasound, 4D ultrasound), positive electron tomography sweepsRetouch (PET) image, radioscopic image, fluoroscopy images, radiotherapy field photography image, single photon emission computerized tomography(SPECT) composograph (for example, puppet CT image) etc. that image, computer generate.In addition, medical image 146 can also includeMedical image, such as training image, ground truth image, contour images and dosage image.In embodiments, it curesLearning image 146 can receive from image acquiring device 132.Therefore, image acquiring device 132 may include MRI imaging device, CTImaging device, PET imaging device, ultrasonic imaging apparatus, arrangement for perspective, SPECT imaging device, integrated straight line accelerator andMRI imaging device or other be used for obtain patient medical image medical imaging apparatus.Medical image 146 can be with anyThe data of type or any kind of format are received or store, image processing apparatus 112 can be used the medical image 146 withExecute the operation consistent with disclosed embodiment.Memory device 116 can be non-transitory computer-readable medium,For example read-only memory (ROM), phase change random access memory devices (PRAM), static random access memory (SRAM), flash memory are depositedReservoir, random access memory (RAM), dynamic random access memory (DRAM) such as synchronous dram (SDRAM), electrically erasableProgrammable read only memory (EEPROM), static memory are (for example, flash memories, flash disk, static random access memoryDevice) and other kinds of random access memory, cache memory, register, compact disc read-only memory (CD-ROM), digital versatile disc (DVD) or other optical storage devices, cassette tape, other magnetic memory apparatus, or can be used for depositingAny other non-transitory medium of information is stored up, which includes can be by processor 114 or the computer of any other typeImage, data or the computer executable instructions (for example, the computer executable instructions stored in any format) of device access.Computer program instructions can be accessed by processor 114, be read from ROM or any other suitable memory location and byIt is loaded into RAM for being executed by processor 114.For example, memory 116 can store one or more software applicationsProgram.The software application being stored in memory 116 can be for example including for common computer system and being used forThe operating system 143 for the device being under software control.In addition, memory 116 can store can be executed by processor 114 it is wholeA software application or a part of software application journey that can be executed by processor 114 for only storing software applicationSequence.For example, memory device 116 can store one or more radiotherapeutic treatment plans 142.
Image processing apparatus 112 can be communicated via communication interface 118 with network 120, which can communicateGround is coupled to processor 114 and memory 116.Communication interface 118 can be in image processing apparatus 112 and radiotherapy systemCommunication connection is provided between 100 component (for example, component that permission and external device (ED) carry out data exchange).For example, communication connectsMouth 118 can have the interface circuit appropriate for being connected to user interface 136 in some embodiments, the user interface 136It can be hardware keyboards, keypad or touch screen, wherein user can will believe by hardware keyboards, keypad or touch screenBreath is input in radiotherapy system 100.
Communication interface 118 can be for example including network adapter, wire and cable connector, serial connector, USB connector, simultaneouslyTrip link actuator, high speed data transfer adapter (for example, being such as optical fiber, USB 3.0, thunder and lightning interface etc.), wireless network adaptationDevice (for example, being such as WIFI adapter), telecommunication adapter (for example, 3G, 4G/LTE etc.) etc..Communication interface 118 can be withIncluding one or more numbers and/or analogue communication device, permission image processing apparatus 112 is via network 120 and such asThe other machines and device of the component of long range positioning etc are communicated.
Network 120 can provide local area network (LAN), wireless network, cloud computing environment (for example, software, work as servicePlatform for service, infrastructure as service etc.), client-server, wide area network (WAN) etc..For example, network 120 canIt may include the LAN or WAN for having other systems S1 (138), S2 (140) and S3 (141) to be.System S1, S2 and S3 can be withOr system S1, S2, S3 identical as image processing apparatus 112 can be different system.In some embodiments, networkOne or more systems in system in 120 can form the distribution for synergistically executing embodiment described hereinFormula calculating/simulated environment.In some embodiments, one or more system S1, S2 and S3 may include obtaining CT imageThe CT scanner of (for example, medical image 146).In addition, network 120 can connect to internet 122, with remotely resident clothesBusiness device and client are communicated on the internet.
Therefore, network 120 can permit in image processing apparatus 112 and multiple various other systems and device --- such asOIS 128, radiotherapy unit 130 and image acquiring device 132 --- between carry out data transmission.In addition, by OIS 128And/or the data generated of image acquiring device 132 can be stored in memory 116, database 124 and/or hospital dataIn library 126.In order to access as desired by processor 114, which can pass through communication interface via network 120118 send/receive.
Image processing apparatus 112 can be communicated by network 120 with database 124, be stored in data with transmission/receptionMultiple various types of data on library 124.For example, database 124 may include following machine datas: the machine data be withRadiotherapy unit 130, image acquiring device 132 or the associated information of other related with radiotherapy machines.Number of machinesIt is believed that breath may include beam sizes, arc is placed, beam unlatches and closes duration, machine parameter, segmentation, leafy collimationDevice (MLC) configuration, gantry speed, MRI pulse train etc..Database 124 can be storage device and database 124 can matchHave database management language program appropriate.It will be appreciated by those skilled in the art that database 124 may include with centerOr multiple devices of distribution mode positioning.
In some embodiments, database 124 may include processor read/write memory medium (not shown).AlthoughProcessor read/write memory medium in embodiment can be single medium, but term " processor read/write memory medium "It should be considered as single medium or multiple medium (examples including storing a group or more groups of computer executable instructions or dataSuch as, centralized data base or distributed data base and/or associated cache memory and server).Term " processingDevice read/write memory medium " shall also be taken to include one group of instruction for being executed by a processor can be carried out storage orAny medium of coding, and any one of method for making processor execute present disclosure in this way or more method.Therefore, term " processor read/write memory medium " should be considered as including but not limited to solid-state memory, optics and magnetic JieMatter.For example, processor read/write memory medium can be one or more volatibility, non-transitory or non-volatile tangible meterCalculation machine readable media.
Image processor 114 can be communicated with database 124, and image is read into memory 116 or will be come from and is depositedThe image of reservoir 116 is stored to database 124.It is obtained for example, database 124 can be configured to storing data library 124 from imageThe 132 received multiple images of institute of device are (for example, 3D MRI, 4D MRI, 2D MRI sectioning image, CT image, 2D fluoroscopy images, XRay image passes through digital imagery in terms of MR scanning or the initial data of CT scan, medical data and communication (DIMCOM)Deng).Database 124 can be stored when executing software program 144 or when establishing radiotherapeutic treatment plan 142 to by schemingThe data used as processor 114.Database 124 can store the data as caused by trained neural network, this is trainedNeural network include constituting the model learned by network and the thus network parameter of generated prediction data.At imageManaging device 112 can be from database 124, radiotherapy unit 130 (for example, MR-Linac) and/or from image acquiring device132 receive imaging data 146 (for example, 2D MRI sectioning image, CT image, 2D fluoroscopy images, radioscopic image, 3D MRIImage, 4D MRI image etc.), to generate treatment plan 142.
In embodiments, radiotherapy system 100 may include following image acquiring devices 132: the image obtains dressThe medical image of patient can be obtained (for example, Magnetic resonance imaging (MRI) image, 3D MRI, 2D streaming MRI, 4D body by setting 132Product MRI, computed tomography (CT) image, conical beam CT, position emissron tomography (PET) image, functional MRI image(for example, fMRI, DCE-MRI and diffusion MR I), radioscopic image, fluoroscopy images, ultrasound image, radiotherapy field photography image, listPhoton emission computed tomography (SPECT) image etc.).Image acquiring device 132 may, for example, be MRI imaging device, CTImaging device, PET imaging device, Vltrasonic device, arrangement for perspective, SPECT imaging device or any other for obtaining patient'sThe suitable medical imaging apparatus of one or more medical images.It can be with by image acquired in image acquiring device 132It is stored in database 124, as imaging data and/or test data.By way of example, pass through image acquiring deviceThe medical image 146 that image acquired in 132 is also used as in memory 116 is stored by image processing apparatus 112.
In embodiments, for example, image acquiring device 132 can be combined as individually filling with radiotherapy unit 130Set (for example, MRI device in conjunction with linear accelerator, also referred to as " MR-Linac ").This MR-Linac for example can be withFor determining the position of target organ or target tumour in patient body, to be radiated according to radiotherapeutic treatment plan 142Pre-determined target is accurately directed toward in treatment.
Image acquiring device 132 can be configured to obtain patient dissection for area-of-interest (for example, target deviceOfficial, target tumour or both target organ and target tumour) one or more images.Each image especially 2D image or sliceIt may include one or more parameters (for example, 2D slice thickness, orientation and position etc.).In embodiments, image obtainsThe 2D of the available any orientation of device 132 is taken to be sliced.For example, 2D slice orientation may include sagittal orientation, it is coronal orientation,Or axial orientation.Processor 114 can be adjusted one or more parameters such as 2D thickness being sliced and/or orientation,To include target organ and/or target tumour.In embodiments, 2D slice can by the information of such as 3D MRI volume etc comeIt determines.When patient is receiving radiation therapy treatment, for example when using radiotherapy unit 130, this 2D sliceIt can be obtained in a manner of " almost in real time " image acquiring device 132." almost in real time " means at least millisecond or moreThe short time obtains data.
Image processing apparatus 112 can be generated and store the radiotherapeutic treatment plan for one or more patients142.Radiotherapeutic treatment plan 142 can provide information related with the specific radiation dosage to be applied to each patient.It putsPenetrate therapy treatment plan 142 can also include other radiation therapy informations, such as beam angle, dose volume histogram information,Quantity, the dosage of every beam etc. of radiation beam ready for use during treatment.
Image processor 114 can be by utilizing such as therapy plot software such as by the Elekta of Stockholm, SWEManufactured by AB companyEtc software program 144 generate radiotherapeutic treatment plan 142.In order to generateRadiotherapeutic treatment plan 142, image processor 114 can with image acquiring device 132 (for example, CT device, MRI device,PET device, X-ray apparatus, Vltrasonic device etc.) communication, to access the image of patient and delineate target, such as delineate tumour.?In some embodiments, to one or more organs (OAR) on the line --- such as around tumour or with tumour poleFor close health tissues --- delineate may be necessary.Therefore, when OAR is close to target tumour, it can execute OAR'sSegmentation.In addition, if target tumour close to OAR (for example, prostate of very close bladder or rectum), by by OAR withLesion segmentation, radiotherapy system 100 can not only study the distribution of the dosage in target but also can study the dosage in OAR pointCloth.
In order to delineate the profile of target organ or target tumour according to OAR, receiving the medicine figure of the patient of radiotherapyPicture --- such as MRI image, CT image, PET image, fMRI image, X ray image, ultrasound image, radiotherapy field photography figurePicture, SPECT image etc. --- it can be obtained in a manner of noninvasive by image acquiring device 132, to show in body partPortion's structure.Based on the information from medical image, the 3D structure of relevant anatomy part can be obtained.In addition, in treatment plan mistakeDuring journey, many parameters can be taken into account, to realize effective treatment of target tumour (for example, being used for the reception of target tumourThe enough dose of radiations effectively treated) and the Low emissivity (for example, OAR receives as few as possible dose of radiation) of OAR betweenBalance.The other parameters that may be considered include the position of target organ and target tumour, the position of OAR and target relative to OAR'sMovement.For example, 3D structure can be by drawing the profile of target in each 2D layers of MRI or CT image or slice or drawing OARProfile and by each 2D layers or slice profile combine and obtain.The profile can manually generate (for example, passing through doctorTeacher, radiological dose test man or health care worker utilize such as made by the Elekta AB company of Stockholm, SWEThe MONACO madeTMEtc program and manually generate) or automatically generate (for example, using such as by Stockholm, SWEABAS manufactured by Elekta AB companyTMThe automatic segmentation software based on Atlas etc program and automatically generate).In spyDetermine in embodiment, the 3D structure of target tumour or OAR can be automatically generated by therapy plot software.
After target tumour and OAR are positioned and are delineated, radiological dose test man, doctor or health care workerCan determine to be applied to the dose of radiation of target tumour and determination can by closest to tumour OAR (for example, the left and right parotid gland,Optic nerve, eyes, crystalline lens, inner ear, spinal cord, brain stem etc.) received any the maximum amount of dosage.It is being directed to each anatomical structureAfter (for example, target tumour, OAR) determines dose of radiation, can execute be considered as Inverse Planning process, will be real with determinationOne or more treatment plan parameters of existing required Radiation dose distribution.The example for the treatment of plan parameters includes that volume is delineatedRange, beam around parameter (for example, the volume, which delineates parameter, limits target volume, profile sensitive structure etc.), target tumour and OARAngle Selection, collimator setting and beam time started.During the process of Inverse Planning, doctor can limit following dosesAmount constrained parameters: the dose constraint parameter setting can receive about OAR radiates how many boundaries (for example, limiting for tumor targetDetermine full dosage and zero-dose is limited for any OAR；95% dosage is limited for target tumour；Spinal nerve is limitedReception≤45Gy dosage limits brain stem reception≤55Gy dosage and limits reception < for optic structureThe dosage of 54Gy).The result of Inverse Planning may constitute the radiation that can be stored in memory 116 or database 124 and treatMethod treatment plan 142.Some treatment parameters in these treatment parameters can be interrelated.Such as, it is intended to adjust a parameter(for example, for the weight of different receptors, for example increasing the dosage about target tumour) with change treatment plan may influence toAnother few parameter, this may cause the research and development of different treatment plans again.Therefore, tool can be generated in image processing apparatus 112There is the customized radiotherapeutic treatment plan 142 of these parameters, is provided for use in radiotherapy unit 130 to patientRadiation therapy treatment.
In addition, radiotherapy system 100 may include display device 134 and user interface 136.Display device 134 can be withIncluding display medical image, interface message, treatment plan parameters (for example, profile, dosage, beam angle etc.), treatment plan,One or more display screens of target, positioning target and/or tracking target or any information related to user.User interface 136Can be keyboard, keypad, touch screen or user can enter information into any kind of dress of radiotherapy system 100It sets.Alternatively, display device 134 and user interface 136 are desirably integrated into such as tablet computer --- such as appleAssociationSamsungDeng --- etc device in.
In addition, any part of radiotherapy system 100 or all components may be implemented as virtual machine (for example, emptyQuasi- machine (VMWare), virtualization technology (Hyper-V) etc.).For example, virtual machine can act as the software of hardware.Therefore, virtuallyMachine may include at least one or more virtual processor for collectively acting as hardware, one or more virtual memory, withAnd one or more virtual communication interfaces.For example, image processing apparatus 112, OIS 128, image acquiring device 132 can be byIt is embodied as virtual machine.In view of available processing capacity, memory and computing capability, entire radiotherapy system 100 can be by realityIt is now virtual machine.
Fig. 2 shows may include radioactive source --- such as x-ray source or linear accelerator ---, therapeutic bed 216, imagingThe exemplary radiation therapy device 202 of detector 214 and radiotherapy output 204.Radiotherapy unit 202 can be configured toEmit radiation beam 208 to provide treatment to patient.Radiotherapy output 204 may include one or more attenuators or standardStraight device, such as multi-diaphragm collimator (MLC).
In Fig. 2, patient can be positioned in region 212, be supported by treatment therapeutic bed 216, according to radiotherapyTreatment plan and receive radiotherapy dosage.Radiotherapy output 204 can be mounted or affixed to rack 206 or other are mechanicalSupporting member.One or more chassis motor (not shown) can make rack when therapeutic bed 216 is inserted into treatment region206 and radiotherapy output 204 around therapeutic bed 216 rotate.In embodiments, rack 206 can be inserted in therapeutic bed 216It can be around 216 continuous rotation of therapeutic bed when entering into treatment region.In another embodiment, rack 206 can be in therapeutic bed216 rotate when being inserted into treatment region to predetermined position.For example, rack 206 can be configured to make treatment output 204 around axisLine (" A ") rotation.Therapeutic bed 216 and radiotherapy output 204 can independently be movable to other positions of surroundings thereofSet --- such as (" T ") can move, can move along lateral (" L ") in transverse direction --- or around one or moreThe rotation of a other axis such as rotates (as indicated by " R ") around transverse axis.It is communicatively connected to one or more actuatorsThe controller of (not shown) can control the movement or rotation of therapeutic bed 216 according to radiotherapeutic treatment plan, to suffer fromPerson is properly positioned in radiation beam 208 or except radiation beam 208.Since therapeutic bed 216 and rack 206 can be with multipleFreedom degree moves independently from each other, this allows patient to be positioned such that radiation beam 208 can accurately target tumor.
Coordinate system shown in Fig. 2 (including axis A, axis T and axis L) can have to be located at and wait at centers 210Origin.Equal centers can be defined as following positions: at this location, the central axis and reference axis of radiation therapy beam 208Origin intersection, by defined dose of radiation be delivered to that patient is upper or patient in.Alternatively, wait centers 210 that can be determinedJustice is following positions: at this location, for such as by rack 206 around the various of the axis A radiotherapy output 204 positionedThe central axis of rotation position, radiation therapy beam 208 intersects with patient.
Rack 206 can also have the imaging detector 214 of attachment.Imaging detector 214 is preferably positioned to and radiatesSource 204 on the contrary, and in embodiments, imaging detector 214 can be located at treatment beam 208 field in.
Imaging detector 214 may be mounted in rack 206, preferably relatively install with radiotherapy output 204In rack 206, to keep and treat beam 208 to be aligned.Imaging detector 214 is with the rotation of rack 206 and around rotation axisRotation.In embodiments, imaging detector 214 can be flat-panel detector (for example, directly detector or scintillator detectionDevice).In this way, imaging detector 214 can be used for monitoring treatment beam 208 or imaging detector 214 and can be used forThe anatomical structure of patient is imaged, such as launched field imaging.The control circuit of radiotherapy unit 202 can be integrated inIt is integrated in system 100 or far from system 100.
In illustrated embodiment, therapeutic bed 216, treatment output one of 204 or rack 206 or more person can be withIt is positioned automatically, and treat output 204 to be penetrated according to the prescribed dose for particular treatment delivery example to establish treatmentBeam 208.Treatment delivering sequence can such as use rack 206, therapeutic bed 216 or treatment output according to radiotherapeutic treatment planOne or more different orientations or position in 204 are specified.Treatment delivering can sequentially occur, but treat deliveringIt can intersect in desired treatment site on patient or in patient, for example intersect at equal centers 210.It is possible thereby to will putThe defined intergal dose for penetrating treatment is delivered to treatment site, while the damage to the tissue near treatment site is reduced or avoidedWound.
Therefore, the example of radiotherapy unit 202 has been shown in particular in Fig. 2, which is operable toRadiation therapy treatment is provided to patient and with wherein radiotherapy output can be around central axis (for example, axis " A ")The configuration of rotation.Other radiotherapy output configurations can be used.For example, radiotherapy output can be installed to moreThe mechanical arm or manipulator of a freedom degree.In yet another embodiment, treatment output can be fixed, such as be located in and patientIn the region being laterally spaced apart, and the platform for supporting patient can be used for centers such as radiotherapies and be located in patient bodyParticular target site alignment.In another embodiment, radiotherapy unit can be linear accelerator and image acquiring deviceCombination.In some embodiments, image acquiring device can be MRI device, X-ray apparatus, CT device, CBCT device,Spiral CT device, PET device, SPECT device, optical tomography device, fluoroscopic imaging device, ultrasonic imaging apparatus orRadiotherapy field photography imaging device etc., as will be recognized those skilled in the art.
Fig. 3 shows the monitor room being monitored in contrast with construction such as the radiotherapy dosage in MR-Linac systemThe example of 300 part.Monitor room 300 includes that room ontology 310, one or more feedthrough components 320 and lid (do not showOut).Mode by way of non-limiting example, room ontology 310 can have rectangular shape, as illustrated in fig 3.RoomOntology 310 can have opening to receive gas and dosage plate hardware and to keep in gas and dosage plate hardwarePortion's compartment.
Lid can be sized to and be suitable for sealing the opening of room ontology 310 securely, to form hermetically sealed insideCompartment.In this example, lid can be such as along the periphery 340 of monitor room 300 by argon arc welding welding to room ontology 310.EachIn kind example, lid and room ontology 310 can be electroplated before being soldered together.
Monitor room 300 can use immobilising device and be fitted into boxlike part.The boxlike part can be with removable sideFormula can be plugged into MR-Linac treatment head.In this example, monitor room 300 includes such as extending from the edge of room ontology 310At least one extension 330.One or more periphery holes 332 on extension 330 can permit fixatorPart --- such as screw or bolt --- is passed through to link room ontology 310 and boxlike part.
Since monitor room 300 may be commonly exposed in high-intensity magnetic field, non-magnetic material can be used and carry out forming chamberOntology 310 or lid.In this example, both room ontology 310 and lid can be made of " 316 grades " stainless steel.It is somebody's turn to do " 316 grades " noRust steel is the stainless steel of the austenite form with 2% to 3% molybdenum ingredient.The molybdenum of addition keeps metal same more resistant to spot corrosion and burn intoWhen tolerance is improved when being exposed to high temperature.The stainless steel of the grade is particularly effective when being used in acidic environment.Pass throughThe metal can prevent corrosion caused by the acid by acetic acid, hydrochloric acid and other forms.In addition, " 316 grades " stainless steel is with fabulousForming characteristic and welding characteristic.It is easy to press shaping die or is rolled into industrial circle, building field and transport fieldApplication various components.By " 316 grades " stainless steel, it is not usually required to carry out post-weld annealed when welding thin section.
Feedthrough component 320 can be accommodated to transmit electricity to dose monitor room transmission telecommunications number or from dose monitor roomThe signal pin of signal.Feedthrough component 320 can be linked to room ontology 310 from its side panel, as shown in Figure 3.In exampleIn, both room ontology 310 and signal pin are all made of metal material (for example, being made of " 316 grades " stainless steel), and feedthroughPart 320 can use insulator such as ceramics insulator and be electrically insulated with room ontology 310.
Fig. 4 A to Fig. 4 B shows the sky being provided with for keeping the airtight environment in dose monitor room (DMC) 400The example of the DMC 400 of gas passage sealing structure 420.DMC 400 is the embodiment of DMC 300.Go out as shown in Figure 4 A, air flue sealing structure 420 can be in a part of the room ontology 410 of DMC 400.Fig. 4 B shows air flueThe cross-sectional view of sealing structure 420.Air duct 421 can be located at the side on the periphery along room ontology 410.Air duct 421With the first opening close to the inside of DMC 400.When the inside of DMC 400 be airtight or DMC 400 in air pressureWhen power is in the range of expectation, sealing structure 420 with seal gas channel 421 and can keep desired in DMC 400Airtight environment.
As illustrated in fig. 4b, sealing structure 420 may include sealing insertion piece 424, the sealing insertion piece 424 constructionIt is engaged at the second opening via the far-end positioned at the inside of DMC 400 with air duct 421.Sealing structure 420 can be withIncluding the first connector 426, which is removably attached to room ontology 410 and is configured to keepAnd bearing seal insertion piece 424.In this example, sealing insertion piece 424 is frictionally engaged with air duct.In order to enhance friction andIn order to keep desired sealing, seals insertion piece 424 and optionally air duct 421 cooperates with sealing insertion piece 424Can shape respectively shape and being shaped to of part ensures to seal the close-coupled between insertion piece 424 and air duct 421.OneIn a example, sealing insertion piece 424 has tapered sealing shank, and air duct 421 has with sealing insertion piece 424 graduallyThe consistent tapered receptacle of contracting shank.In another example, there is sealing insertion piece 424 arch to seal shank, and airChannel 421 has the tapered receptacle to receive the arch shank of sealing insertion piece 424.In another example, sealing insertionPart 424 has the sealing shank at right angle engaged to the tapered receptacle with air duct 421.
Sealing insertion piece 424 has cylindrical shaft.Seal rubber part 425 can circumferentially around sealing insertion piece axis extremelyFew a part winding.First connector 426 can be kept and bearing seal rubber parts 425.Seal rubber part 425 and to prop upThe first connector 426 held can be frictionally engaged with air duct 421.In some instances, sealing insertion piece 424 can be withIt additionally include the threaded sealed interface to be engaged with air duct 421.
Sealing structure 420 may include the second connector 423 for being removably attached to room ontology 410.ConnectionDevice 423 can have interface 422, which is configured to and to the air by air duct 421 in DMC 400Pressure be monitored pressure gauge (not shown) engagement.Alternatively or in addition, interface 422 can with to DMC 400The air pump engagement that the pressure of the interior air by air duct 421 is adjusted.Interface 422 can have screw thread or similarCoupling mechanism to be engaged with air pressure gage and air pump.
In some instances, sealing structure 420 may include fixing in an adjustable way will seal insertion piece 424Retainer 427 in air duct 421.The retainer can be with the threaded receptacle of joint seal insertion piece, so that onlyMoving part lateral magnification is used to be sealed air inlet in turn.Mode by way of non-limiting example, retainer may include screw.Once establishing airtight environment in the inside of DMC 400, then retainer can be screwed into sealing insertion piece 424, so that retainerIt is extending transversely firm to help to be sealed sealing insertion piece 424 and make to seal insertion piece 424.Sky in DMC 400Atmospheric pressure is needed to be examined (for example, being checked using pressure gauge) or needs to be conditioned (for example, being carried out using air pumpAdjust) when, screw can be unscrewed so as to seal insertion piece 424 and retreat more to the left so that air duct 421 lead to pressure gauge orAir pump.
Seal rubber part 425 and the first connector 426 to support only can suck air or connection pressure with pumpUse when meter is to monitor pressure.By being sealed to air duct 421, seal rubber part 425 can be to avoid air from left sideLeakage allows air only along the direction flowing of the instruction of the arrow as shown in Fig. 4 B.In some instances, it is not executingWhen air pressure inspection or air pressure are adjusted, seal rubber part 425 and the first connector 426 to support can be movedIt removes.Go out as shown in Figure 4 A and 4 B, connector 423 could be attached to another sealing being spaced apart with seal rubber part 425Rubber parts 428, another seal rubber part 428 are pre-installed before carrying out pressure inspection or pressure adjusting.Seal rubberPart 428 can contribute to the engagement of the second connector 423 fixing and facilitating pressure test or pressure adjusting and equip.
Above description includes the reference to attached drawing, and attached drawing forms a part of the detailed description.The side that attached drawing passes through diagramFormula, which is shown, can be implemented specific embodiment of the present utility model.These embodiments are referred to herein as " example ".ThisThe example of sample may include the element other than shown or described element.However, inventor herein is contemplated that itIn provide only the example for those of showing or describing element.It has used in addition, inventor herein is contemplated that about specificExample (or one or more aspect) or about other shown or described herein examples (or one or moreAspect) and those of show or describe any combination of element or displaced example.
In the case where having inconsistent usage between the literature and any document being incorporated by reference into, then in the literatureIn usage subject to.
As common in the patent literature, in the literature, term " one (a or an) " is used for including one or is more than oneIt is a, independently of "at least one" or any other example or usage of " one or more ".In the literature, unless otherwiseIllustrate, otherwise term "or" is for indicating nonexcludability so that " A or B " include " A but without B ", " B but without A " and " A withB".In the literature, term " including (including) " and " wherein (in which) " be used as corresponding term " includingAnd the plain English equivalent of " wherein (wherein) " (comprising) ".In addition, in the dependent claims, term" including (including) " and " including (comprising) " is open, that is, including in addition in claims at thisSystem, device, article, composition, formula or the technique of element except the element listed after kind term are still considered to be inIn the range of the claims.In addition, in the dependent claims, term " first ", " second " and " third " etc. are only usedIt marks, it is no intended to which numerical requirements are applied to its object.
Unless otherwise indicated by context, otherwise geometric terminology, such as " parallel ", " vertical ", " circle " or " rectangular " not purportRequiring absolute mathematical accuracy.On the contrary, this geometric terminology allows the modification because of caused by manufacture or equivalent function.For example,If element is described as " circle " or " roughly circular ", be not exact circle component (for example, slightly oval component orPolygonal features) still covered by the description.
The above description is intended to be illustrative and not restrictive.For example, example described above (or one or moreA aspect) it can be in combination with one another.Can be used other embodiments, for example, by those of ordinary skill in the art browsing withAfter upper description.Abstract is provided to meet 37C.F.R. § 1.72 (b), so that reader can quickly determine that technology is disclosed originallyMatter.Made a summary with following understandings to submit: abstract is not used in explanation or limits the range or meaning of claims.Moreover, withIn upper detailed description, various features can be combined to simplify present disclosure.This is not necessarily to be construed as meaning not requestingThe disclosed feature of protection is essential for any claim.On the contrary, utility model theme can be less than spyDetermine all features of disclosed embodiment.Therefore, the appended claims are incorporated into detail as example or embodimentIn description, wherein each claim itself is as individual embodiment, and it is expected that these embodiments can be withVarious combinations or displacement are combined with each other.The scope of the utility model should be wanted referring to the appended claims and such rightThe full scope of the equivalent for asking book to be entitled to determines.