CN209102742U - A cavity assembly structure - Google Patents

Abstract

Translated fromChinese

本实用新型提供一种腔体的装配结构，能够与腔体可拆式的连接或者结合。该腔体的装配结构能够将收集到的样本进行分离，使需要进行二次确认检测的样本与初始检测的样本分离开来，能够独立密封并被送往检测机构进行确认检测。本设置了本实用新型的装配结构的样本收集装置，能够将收集到样本分到不同的腔室内，不同的腔室能够根据收集、分离或者检测的需要实现部分连通或者隔断，通过一次收集获得二次检测所需的样本并能够分别存储，确认检测的样本和初始检测的样本以及测试元件之间不会发生污染，确保不会影响二次确认的效果。

The utility model provides an assembly structure of a cavity, which can be detachably connected or combined with the cavity. The assembly structure of the cavity can separate the collected samples, so that the samples that need to be tested for secondary confirmation and the samples of the initial test can be separated, and can be independently sealed and sent to the testing agency for confirmation testing. The sample collection device with the assembly structure of the present invention is provided, which can divide the collected samples into different chambers, and different chambers can be partially connected or separated according to the needs of collection, separation or detection. The samples required for the second test can be stored separately to confirm that there will be no contamination between the tested samples and the initial test samples and test elements, ensuring that the effect of the second confirmation will not be affected.

Description

Translated fromChinese

一种腔体的装配结构A cavity assembly structure

技术领域technical field

本实用新型涉及收集液体样本的装置，尤其是快速诊断领域内的收集和检测液体样本中被分析物质的装置，例如尿液收集和检测装置，具体涉及一种样本收集装置中的腔体的装配结构。The utility model relates to a device for collecting liquid samples, in particular to a device for collecting and detecting analytes in liquid samples in the field of rapid diagnosis, such as a urine collecting and detecting device, in particular to an assembly of a cavity in a sample collecting device structure.

背景技术Background technique

目前，用于检测样本中是否含有被分析物质的检测装置，被大量用于医院或者家中，这些应用于快速诊断的检测装置包含一种或多种检测试剂条，比如早孕检测，毒品滥用检测等等。这种快速诊断的检测装置非常便利，可以在一分钟，或者至多十分钟左右在检测试剂条上得到检测结果。At present, detection devices for detecting whether a sample contains analyte substances are widely used in hospitals or at home. These detection devices for rapid diagnosis include one or more detection reagent strips, such as early pregnancy detection, drug abuse detection, etc. Wait. This kind of rapid diagnosis detection device is very convenient, and the detection result can be obtained on the detection reagent strip in one minute, or at most ten minutes.

毒品检测应用广泛，常用于禁毒部门、公安局、戒毒所、体检中心、国家征兵体检处等机构。毒品检测种类多样，次数频繁，能自动分离剩余样本与被检测样本的毒品检测尿杯具有巨大的市场需求，目前市场上的毒品检测尿杯在检测完成之后，尿杯中的样本就会受到检测试剂的污染而不能继续用于第二次确认检测，例如美国专利7300633描述的那样。Drug detection is widely used, and is often used in anti-drug departments, public security bureaus, drug rehabilitation centers, physical examination centers, national military recruitment physical examination offices and other institutions. There are various types of drug testing and frequent frequency. There is a huge market demand for drug testing urine cups that can automatically separate the remaining samples from the tested samples. After the drug testing urine cups currently on the market are tested, the samples in the urine cups will be tested. Contamination of the reagents cannot be continued for a second confirmatory test, such as described in US Pat. No. 7,300,633.

虽然，在传统的技术中，可以让被检测的样本与收集的样本进行隔离，但是成本高，而且不容易操作。例如美国专利，专利号7300633描述的活塞尿杯，当推动活塞前进的过程中，让收集腔里的液体样本，例如尿液，从收集腔转移到检测腔，在检测腔里有检测样品中被分析物质的测试元件，而收集腔的液体样本被活塞隔离开来，从而两个地方的样品不会混淆，从而可以用来以后的确认检测。虽然这样可以隔离开检测的样本和收集的样本，但是这种活塞的尿杯成本高，而且操作不容易，毕竟推动活塞需要比较大的力气，这是因为活塞需要达到转移样本，必然需要和活塞的壁起到液体密封的效果，达到密封的效果需要让活塞和活塞腔紧密的结合。Although, in traditional techniques, it is possible to isolate the tested sample from the collected sample, but it is expensive and not easy to operate. For example, U.S. Patent No. 7,300,633 describes the piston urine cup. When the piston is pushed forward, the liquid sample in the collection chamber, such as urine, is transferred from the collection chamber to the detection chamber, and there is a detection sample in the detection chamber. The test element for analysing the substance, and the liquid sample in the collection chamber are separated by a piston, so that the samples in the two places are not mixed up and can be used for subsequent confirmatory testing. Although this can separate the detected sample and the collected sample, the urine cup of this kind of piston is expensive and difficult to operate. After all, it takes a lot of force to push the piston. This is because the piston needs to reach the transfer sample, and it is necessary to communicate with the piston. The wall of the cylinder plays the role of liquid sealing, and to achieve the sealing effect, the piston and the piston cavity need to be tightly combined.

再例如，美国专利8992855描述了一种收集液体样本的装置，该装置包括与盖子连为一体并与盖子一起运动的活塞结构，虽然可以检测样本与收集的样本分开，但是当检测样本进入检测腔后，需要克服很大的压力才能进入，而且需要精密设计盖子与杯口的尺寸，这样与盖子连为一体的活塞才能准确的插入到分离腔中。For another example, US Pat. No. 8,992,855 describes a device for collecting liquid samples. The device includes a piston structure that is integrally connected with a cover and moves together with the cover. Although the test sample can be separated from the collected sample, when the test sample enters the test chamber. Afterwards, it needs to overcome a lot of pressure to enter, and it is necessary to precisely design the size of the lid and the mouth of the cup, so that the piston integrated with the lid can be accurately inserted into the separation chamber.

另外，这些传统的收集和检测装置等初步测试完成后，如果需要后续进行确认检测，需要把整个收集和检测装置运送到确认检测机构进行进一步的确认检测，这就带来了很多问题，至少具有这样的问题：第一，目前大部分液体收集和检测装置只设有初步检测腔。如果需要后续确认检测时，只能将含有尿液和检测试剂条的整个装置送往确认检测机构进行检测。尿杯中的样本就有可能受到检测试剂的污染。第二，把整个装置送往确认检测机构时，由于杯口较大，在运输过程中液体有泄漏的风险，这就需要更多的成本来让装置具有更好的密封效果，从而尽量减少泄漏的风险；第三，将整个装置运送到确认检测机构之后，确认检测机构需要巨大低温仓库来存放整个检测装置，防止液体样本变质，为了后续可能的进一步确认检测做准备，这样造成确认检测机构(可以称为二次检测机构)成本大幅升高。In addition, after the preliminary tests such as these traditional collection and detection devices are completed, if subsequent confirmation testing is required, the entire collection and detection device needs to be transported to a confirmation testing agency for further confirmation testing, which brings many problems. Such problems: First, most of the current liquid collection and detection devices are only provided with a preliminary detection chamber. If subsequent confirmation testing is required, only the entire device containing urine and test reagent strips can be sent to a confirmation testing institution for testing. The sample in the urine cup may be contaminated with the test reagents. Second, when the whole device is sent to the confirmation testing agency, due to the large mouth of the cup, there is a risk of liquid leakage during transportation, which requires more cost to make the device have a better sealing effect, thereby minimizing leakage Third, after the entire device is transported to the confirmation testing agency, the confirmation testing agency needs a huge low-temperature warehouse to store the entire testing device to prevent the liquid sample from deteriorating, and prepare for subsequent possible further confirmation testing, which causes the confirmation testing agency ( It can be called as a secondary detection mechanism) The cost is greatly increased.

针对上述一些技术问题，故需要对其进行改进，提供另外的途径解决现有传统技术的不足。In view of some of the above technical problems, it is necessary to improve them and provide another way to solve the deficiencies of the existing traditional technology.

实用新型内容Utility model content

针对上述情况，为克服现有技术的缺陷，本实用新型所要解决的技术问题是提供一种腔体的装配结构，该腔体的装配结构能够将收集到的样本进行分离，使需要进行二次确认检测的样本与初始检测的样本分离开来，能够独立密封并被送往检测机构进行确认检测。本设置了本实用新型的装配结构的样本收集装置，能够将收集到样本分到不同的腔室内，不同的腔室能够根据收集、分离或者检测的需要实现部分连通或者隔断，通过一次收集获得二次检测所需的样本并能够分别存储，确认检测的样本和初始检测的样本以及测试元件之间不会发生污染，确保不会影响二次确认的效果。In view of the above situation, in order to overcome the defects of the prior art, the technical problem to be solved by the present invention is to provide an assembly structure of a cavity, and the assembly structure of the cavity can separate the collected samples, so that the need for secondary The samples for confirmation testing are separated from the samples for initial testing, can be independently sealed and sent to testing institutions for confirmation testing. The sample collection device provided with the assembly structure of the present invention can divide the collected samples into different chambers, and different chambers can be partially connected or separated according to the needs of collection, separation or detection. The samples required for the secondary test can be stored separately to confirm that there will be no contamination between the tested samples and the initial test samples and test elements, ensuring that the effect of the secondary confirmation will not be affected.

为解决上述技术问题，本实用新型提供以下技术方案：In order to solve the above-mentioned technical problems, the utility model provides the following technical solutions:

一种腔体的装配结构，装配结构能够与腔体可拆式的连接或者结合。An assembly structure of a cavity can be detachably connected or combined with the cavity.

进一步地，装配结构能够与其他部件可拆式的连接或者结合。Further, the assembly structure can be detachably connected or combined with other components.

进一步地，装配结构包括外壁和内腔。Further, the assembly structure includes an outer wall and an inner cavity.

进一步地，腔体能够被装入内腔中。Further, the cavity can be fitted into the inner cavity.

进一步地，腔体和内腔可以采用固定结合、固定连接或者可拆式结合可拆式连接的形式装配在一起。Further, the cavity and the inner cavity can be assembled together in the form of fixed combination, fixed connection or detachable combination and detachable connection.

进一步地，装配结构的外壁上设有一些镂空结构。Further, some hollow structures are provided on the outer wall of the assembly structure.

进一步地，装配结构具有一个便于该装配结构和盖体进行结合或者分离的元件。Further, the assembly structure has an element that facilitates the combination or separation of the assembly structure and the cover.

进一步地，这个元件是把手或者旋钮。Further, this element is a handle or a knob.

进一步地，装配结构上设有定环，固定环套设在腔体上，并能与腔体的一端固定连接、结合或者可拆式的连接或者结合。Further, the assembly structure is provided with a fixed ring, which is sleeved on the cavity and can be fixedly connected, combined or detachably connected or combined with one end of the cavity.

进一步地，固定环均位于装配结构的下端。Further, the fixing rings are all located at the lower end of the assembly structure.

进一步地，还包括腔体的密封件，密封件固定在装配结构上。Further, it also includes a sealing member of the cavity, and the sealing member is fixed on the assembly structure.

以下技术方案也属于本实用新型的内容：The following technical solutions also belong to the content of the present utility model:

本实用新型的第一方面，本实用新型提供一种样本检测装置，包括用于收集液体样本的第一腔和用于收集确认检测样本的第二腔，第一腔和第二腔能够处于液体连通或隔断的状态，当第一腔和第二腔处于液体连通状态时，第一腔内的液体能够在外力作用下被转移到第二腔内。In a first aspect of the present invention, the present invention provides a sample detection device, comprising a first cavity for collecting liquid samples and a second cavity for collecting confirmation detection samples, the first cavity and the second cavity can be in liquid In the connected or disconnected state, when the first cavity and the second cavity are in the liquid communication state, the liquid in the first cavity can be transferred into the second cavity under the action of external force.

在一些优选的方式中，外力可以是重力作用。在一些优选的方式中，外力是除了重力以外的其他作用力。在一些优选的方式中，除了重力以外的其他作用力，包含接触和/或非接触式的压力、推力、挤压力等等。在一些优选的方式中，外力可以是克服重力的作用力。在一些优选的方式中，外力可以是克服重力以外的其他的作用力，例如冲破某个阻塞物或者通过某个开口。在一些优选的方式中，外力可能是结构内部所产生的力。在一些优选的方式中，外力可以是通过结构或者配合而在结构内部形成的某种力，例如压差所产生的推动力或者负压或者真空所产生的吸引力。在一些优选的方式中，可以将第二腔设置为真空，在第一腔和第二腔能够液体连通的情况下，液体可能就会由于压差的作用从第一腔流向第二腔。在一些优选的方式中，第二腔不一定要完全真空，只要使第二腔的内压小于第一腔，也可以实现上述的压差作用。在一些优选的方式中，可以对第一腔进行增压，也能够实现上述的压差作用。In some preferred ways, the external force may be the effect of gravity. In some preferred modes, the external force is a force other than gravity. In some preferred manners, other forces other than gravity include contact and/or non-contact pressure, thrust, squeezing force, and the like. In some preferred ways, the external force may be a force against gravity. In some preferred manners, the external force may be a force other than gravity, such as breaking through an obstruction or passing through an opening. In some preferred ways, the external force may be a force generated inside the structure. In some preferred manners, the external force may be a certain force formed inside the structure through the structure or cooperation, such as a pushing force generated by a pressure difference or an attractive force generated by a negative pressure or a vacuum. In some preferred manners, the second chamber can be set as a vacuum, and under the condition that the first chamber and the second chamber can be in liquid communication, the liquid may flow from the first chamber to the second chamber due to the pressure difference. In some preferred manners, the second chamber does not have to be completely evacuated, as long as the internal pressure of the second chamber is lower than that of the first chamber, the above-mentioned pressure difference effect can also be achieved. In some preferred manners, the first chamber can be pressurized, and the above-mentioned pressure difference effect can also be achieved.

在一些优选的方式中，第一腔能够直接收集到样本，或者第一腔能够与另外的腔室连通从而直接或间接地接收到样本，无论是直接还是间接接收，这种接收方式都是不需要外力辅助的，例如，第一腔直接具有一个可以接收样本的开口，或者第一腔具有一个与其他直接接收样本的腔体液体连通的开口，样本可以在重力作用下通过其他的腔室滑入第一腔，这个过程可以由收集的过程自然实现，不需要辅助外力。In some preferred ways, the first chamber can directly collect the sample, or the first chamber can communicate with another chamber to receive the sample directly or indirectly, whether directly or indirectly, this receiving method is not When external force is required, for example, the first chamber directly has an opening that can receive the sample, or the first chamber has an opening that is in liquid communication with other chambers that directly receive the sample, and the sample can slide through the other chambers under the action of gravity. Into the first cavity, this process can be realized naturally by the collection process without auxiliary external force.

在一些优选的方式中，在没有外力作用之下，第一腔和第二腔之间是处于液体隔断状态的，也就是说，这种情况下，第一腔和第二腔之间是没有液体连通的；而在施加了外力作用的情况下，第二腔与第一腔之间可以实现液体连通，在第一腔和第二腔实现液体连通的状态下，第一腔内的样本可以在一定的压力下被转移到第二腔内，也就是说，第一腔内的样本要转移到第二腔内必须要施加一定的外力，这个过程无法通过自然动力(例如重力)来实现，当第二腔收集到合适的量的样本之后，撤去外力，第一腔和第二腔又能够恢复到液体隔断的状态。在一些优选的方式中，使第一腔和第二腔实现液体连通状态的外力和使第一腔内的样本向第二腔内转移的外力可以是同一个外力，在一些优选的方式中，使第一腔和第二腔实现液体连通状态的外力和使第一腔内的样本向第二腔内转移的外力可以是不同的外力。In some preferred manners, under no external force, the first cavity and the second cavity are in a state of liquid isolation, that is, in this case, there is no liquid between the first cavity and the second cavity. In the case of applying external force, liquid communication can be achieved between the second cavity and the first cavity, and in the state where the first cavity and the second cavity are in liquid communication, the sample in the first cavity can be It is transferred to the second chamber under a certain pressure, that is to say, a certain external force must be exerted for the sample in the first chamber to be transferred to the second chamber. This process cannot be achieved by natural forces (such as gravity), After the second chamber collects an appropriate amount of sample, the external force is removed, and the first chamber and the second chamber can be restored to the state of liquid isolation. In some preferred ways, the external force that makes the first cavity and the second cavity realize the liquid communication state and the external force that makes the sample in the first cavity transfer to the second cavity can be the same external force. In some preferred ways, The external force for making the first cavity and the second cavity realize the liquid communication state and the external force for transferring the sample in the first cavity to the second cavity may be different external forces.

作为一种可能的实现方式，例如第一腔具有一个通往第二腔的开口，这个开口具有不受压的情况下常闭而受压可以打开的特点，这样，在第一腔内的收集到的液体在受到压力的情况下，可以通过这个开口进入到第二腔内，当压力撤除时，这个开口又恢复闭合，完成第一腔内的样本向第二腔内的转移。As a possible implementation, for example, the first chamber has an opening leading to the second chamber, and the opening is normally closed under no pressure and can be opened under pressure, so that the collection in the first chamber The obtained liquid can enter the second chamber through the opening under pressure, and when the pressure is removed, the opening is closed again, and the transfer of the sample in the first chamber to the second chamber is completed.

作为一种可能的实现方式，第二腔和第一腔之间可以设置一个连通器，这个连通器可以在一定的条件下(例如收到压力)的情况下将第一腔和第二腔的内部连通，使得第一腔和第二腔实现液体连通，在这种情况下，第一腔内的样本可以转移到第二腔内，转移完成后，可以撤去连通器，使第二腔封闭。As a possible implementation, a communication device can be set between the second cavity and the first cavity, and the communication device can connect the first cavity and the second cavity under certain conditions (such as receiving pressure). The internal communication enables the first cavity and the second cavity to achieve liquid communication. In this case, the sample in the first cavity can be transferred to the second cavity. After the transfer is completed, the communication device can be removed to seal the second cavity.

作为一种可能的实现方式，这个连通器可以具有一个刺破口，第二腔具有一个密封口，密封口可以被这个刺破口刺破，当连通器撤去之后，这个密封口又可以恢复液体密封，例如采用橡胶材质封口，这个刺破口在外力作用下可以刺入密封口，使第一腔和第二腔连通，第一腔内的液体在受压的情况下可以通过这个刺破口进入到第二腔内。As a possible implementation, the communicating device may have a piercing opening, the second cavity has a sealing opening, the sealing opening can be pierced by the piercing opening, and when the communicating device is removed, the sealing opening can restore the liquid Seal, for example, use rubber material to seal, this piercing opening can pierce the sealing opening under the action of external force, so that the first cavity and the second cavity are connected, and the liquid in the first cavity can pass through this piercing opening under pressure into the second chamber.

本实用新型的第二方面，本实用新型提供用于初始收集样本的第三腔，第三腔和第一腔能够与第一腔处于液体连通或隔断的状态。In the second aspect of the present invention, the present invention provides a third cavity for initially collecting samples, and the third cavity and the first cavity can be in a state of liquid communication or isolation with the first cavity.

在一些优选的方式中，第三腔可以和第一腔处于自然液体连通的状态，也就是说，第三腔内的液体可以在不需要外力的作用下自然地流入到第一腔内，在一些优选的方式中，第一腔内的液体也可以在不需要外力的作用下自然地流入到第三腔内。In some preferred manners, the third cavity can be in a state of natural liquid communication with the first cavity, that is, the liquid in the third cavity can flow into the first cavity naturally without external force. In some preferred manners, the liquid in the first cavity can also flow into the third cavity naturally without external force.

在一些优选的方式中，第三腔和第一腔在外力作用下处于液体连通的状态，也就是说，第三腔内的流体不会主动流入到第一腔内，需要施加一定的外力才可以实现流体从第三腔到第一腔的流动。在一些优选的方式中，第一腔内的流体不会主动流入第三腔内，需要施加一定的外力才可以实现流体从第一腔到第三腔的流动。In some preferred manners, the third cavity and the first cavity are in a state of liquid communication under the action of external force, that is, the fluid in the third cavity will not actively flow into the first cavity, and a certain external force is required to The flow of fluid from the third chamber to the first chamber can be achieved. In some preferred manners, the fluid in the first cavity does not actively flow into the third cavity, and a certain external force is required to realize the flow of the fluid from the first cavity to the third cavity.

在一些优选的方式中，第三腔和第一腔处于液体隔断状态，也就是说，第一腔内的液体无法流入到第三腔内，第三腔内的液体也无法流入到第一腔内，这种隔断的状态可以通过外力来打破，也就是说，在一些可能的情况下，可以通过外力实现第一腔和第三腔之间的液体连通的状态。例如，在一些优选的方式中，在初始收集样本时，第三腔内先收集到样本，样本在无作用力的情况下不会进入到第一腔内。In some preferred manners, the third cavity and the first cavity are in a liquid-blocking state, that is, the liquid in the first cavity cannot flow into the third cavity, and the liquid in the third cavity cannot flow into the first cavity either. Inside, this partition state can be broken by external force, that is, in some possible cases, the state of liquid communication between the first cavity and the third cavity can be realized by external force. For example, in some preferred manners, when the sample is initially collected, the sample is first collected in the third chamber, and the sample will not enter the first chamber without any force.

在一些优选的方式中，第三腔可以作为初始收集样本的腔体，如前第一方面所述，第一腔或第三腔均可以作为初始收集样本的腔体，第一腔和第三腔之间也可以实现液体连通，这样第三腔内收集的液体样本可以流入到第一腔内，实现第一腔内的样本收集。In some preferred manners, the third chamber can be used as the chamber for initially collecting samples. As described in the first aspect, either the first chamber or the third chamber can be used as the chamber for initially collecting samples. Liquid communication can also be achieved between the chambers, so that the liquid sample collected in the third chamber can flow into the first chamber to realize sample collection in the first chamber.

在一些优选的方式中，第一腔和第三腔之间具有液体连通的第一通道，流体可以通过该第一通道从第一腔进入第三腔或者从第三腔进入第一腔。在一些优选的方式中，这个第一通道位于第三腔的底部，这样，进入到第三腔内的样本可以在自身重力的作用下自然流入到第一腔内。In some preferred manners, there is a first channel in liquid communication between the first cavity and the third cavity, through which fluid can enter the third cavity from the first cavity or enter the first cavity from the third cavity. In some preferred manners, the first channel is located at the bottom of the third cavity, so that the sample entering the third cavity can naturally flow into the first cavity under the action of its own gravity.

在一些优选的方式中，第一腔和第三腔之间的第一通道可以被封闭，当第一通道被封闭时，第一腔和第三腔处于液体隔断状态，例如，在一些优选的方式中，样本首先进入第三腔，并可沿前述的第一通道流入第一腔，第一腔内的液体可以在外力作用下进入到第二腔内，在一些优选的方式中，第一腔和第二腔处于液体连通的状态时，第一通道可以被封闭。In some preferred ways, the first channel between the first cavity and the third cavity can be closed, and when the first channel is closed, the first cavity and the third cavity are in a state of liquid isolation, for example, in some preferred In the method, the sample first enters the third chamber, and can flow into the first chamber along the aforementioned first channel, and the liquid in the first chamber can enter the second chamber under the action of external force. When the cavity and the second cavity are in fluid communication, the first channel may be closed.

在一些优选的方式中，第一腔位于第三腔的底部，当第一腔和第三腔流体连通时，第三腔内的液体可以在自重作用下直接流入到第一腔内。In some preferred manners, the first cavity is located at the bottom of the third cavity, and when the first cavity and the third cavity are in fluid communication, the liquid in the third cavity can directly flow into the first cavity under the action of its own weight.

在一些优选的方式中，第三腔内的流体无法在重力作用下自然流入到第一腔内，例如，第一腔和第三腔在自然状态下被隔断，只有在一定压力下才能打开第一腔和第三腔的连通口，在这种情况，第三腔内会被优先装入样本，然后在一定的压力下，例如盖体盖合所产生的挤压力，第三腔内的样本会被向下挤压，受迫进入第一腔内。In some preferred manners, the fluid in the third cavity cannot flow into the first cavity naturally under the action of gravity, for example, the first cavity and the third cavity are blocked in a natural state, and the first cavity can only be opened under a certain pressure. The communication port between the first cavity and the third cavity. In this case, the third cavity will be preferentially loaded with samples, and then under a certain pressure, such as the extrusion force generated by the closure of the cover, the sample in the third cavity will be The sample is squeezed downward, forcing it into the first chamber.

在一些优选的方式中，第三腔内优先被装入样本。在一些优选的方式中第三腔内的样本可以在一定外力的作用下进入第一腔内。In some preferred manners, the third chamber is preferentially loaded with the sample. In some preferred manners, the sample in the third chamber can enter the first chamber under the action of a certain external force.

在一些优选的方式中，第一腔可以设置一个穿过第三腔的第三通道，在初始收集时，这个第三通道内不会被装入样本在一些优选的方式中，第二腔以及第二腔的装配结构可以装配到第三通道上。在一些优选的方式中，第二腔可以直接装配到第三通道上。在一些优选的方式中，第三通道和第三腔具有共用的开口，但是装入样本时，是要稍加注意，便不会让样本进入到第三通道内。在一些优选的方式中，初始收集样本时，第三通道可以被封闭，例如用塞子塞住，或者用薄膜封住。In some preferred manners, the first chamber may be provided with a third channel passing through the third chamber, and during initial collection, the third channel will not be filled with samples. In some preferred manners, the second chamber and The fitting structure of the second cavity can be fitted to the third channel. In some preferred modes, the second cavity may fit directly onto the third channel. In some preferred manners, the third channel and the third cavity have a common opening, but when loading the sample, care should be taken not to allow the sample to enter the third channel. In some preferred ways, the third channel may be closed, eg, plugged with a stopper, or sealed with a membrane, when the sample is initially collected.

在一些优选的方式中，第三腔的底部设置一些能够连通第一腔的开孔。在一些优选的方式中，第一腔和第三腔之间通过压力孔连通，当第三腔内受到压力时，压力孔打开，流体能够直接从第三腔进入到第一腔，当压力撤除时，压力孔又能恢复闭合。在一些优选的方式中，压力孔在闭合状态下，能够承受来第三腔在装满状态下的液体压力，也就是说，仅仅是向第三腔内装入样本，这些样本的自重不足以打开压力孔。在一些优选的方式中，在样本达到一定的收集量时，能够打开压力孔。在一些优选的方式中，压力孔所能承受的压力可以根据实际需要配置。In some preferred manners, the bottom of the third cavity is provided with some openings which can communicate with the first cavity. In some preferred manners, the first chamber and the third chamber are communicated through a pressure hole. When the third chamber is under pressure, the pressure hole is opened, and the fluid can directly enter the first chamber from the third chamber. When the pressure is removed, the pressure hole is opened. When the pressure hole is closed again. In some preferred manners, in the closed state, the pressure hole can withstand the liquid pressure from the third cavity in the full state, that is to say, only the samples are loaded into the third cavity, and the self-weight of these samples is not enough to open pressure hole. In some preferred manners, the pressure port can be opened when the sample reaches a certain collection volume. In some preferred manners, the pressure that the pressure hole can bear can be configured according to actual needs.

本实用新型的第三方面，本实用新型提供用于收集待检测样本的第四腔，第四腔能够与第三腔处于液体连通或隔断的状态。In a third aspect of the present invention, the present invention provides a fourth cavity for collecting samples to be detected, and the fourth cavity can be in a state of liquid communication or isolation with the third cavity.

在一些优选的方式中，第三腔可以和第四腔处于自然液体连通的状态，也就是说，第三腔内的液体可以在不需要外力的作用下自然地流入到第四腔内，在一些优选的方式中，第四腔内的液体也可以在不需要外力的作用下自然地流入到第三腔内。In some preferred manners, the third cavity can be in a state of natural liquid communication with the fourth cavity, that is, the liquid in the third cavity can flow into the fourth cavity naturally without external force. In some preferred manners, the liquid in the fourth chamber can also flow into the third chamber naturally without external force.

在一些优选的方式中，第三腔和第四腔在外力作用下处于液体连通的状态，也就是说，第三腔内的流体不会主动流入到第四腔内，需要施加一定的外力才可以实现流体从第三腔到第四腔的流动。在一些优选的方式中，第四腔内的流体不会主动流入第三腔内，需要施加一定的外力才可以实现流体从第四腔到第三腔的流动。In some preferred manners, the third cavity and the fourth cavity are in a state of liquid communication under the action of external force, that is to say, the fluid in the third cavity will not actively flow into the fourth cavity, and a certain external force is required to The flow of fluid from the third chamber to the fourth chamber can be achieved. In some preferred manners, the fluid in the fourth chamber does not actively flow into the third chamber, and a certain external force is required to realize the flow of the fluid from the fourth chamber to the third chamber.

在一些优选的方式中，第三腔和第四腔处于液体隔断状态，也就是说，第一腔内的液体无法流入到第三腔内，第三腔内的液体也无法流入到第四腔内，这种隔断的状态可以通过外力来打破，也就是说，在一些可能的情况下，可以通过外力实现第四腔和第三腔之间的液体连通的状态。In some preferred manners, the third cavity and the fourth cavity are in a liquid blocking state, that is, the liquid in the first cavity cannot flow into the third cavity, and the liquid in the third cavity cannot flow into the fourth cavity. Inside, this partition state can be broken by external force, that is, in some possible cases, the state of liquid communication between the fourth cavity and the third cavity can be realized by external force.

在一些优选的方式中，如前第二方面所述，第三腔均可以作为初始收集样本的腔体，第四腔和第三腔之间也可以实现液体连通，这样第三腔内收集的液体样本可以流入到第四腔内，实现第四腔内的样本收集。In some preferred manners, as described in the second aspect, the third cavity can be used as a cavity for initially collecting samples, and liquid communication can also be achieved between the fourth cavity and the third cavity, so that the collected samples in the third cavity The liquid sample can flow into the fourth chamber to realize sample collection in the fourth chamber.

在一些优选的方式中，第四腔和第三腔之间具有液体连通的第二通道，流体可以通过该第二通道从第三腔进入第四腔或者从第四腔进入第三腔。在一些优选的方式中，这个第二通道位于第三腔的底部，这样，进入到第三腔内的样本可以在自身重力的作用下自然流入到第四腔内。In some preferred manners, there is a second channel in liquid communication between the fourth cavity and the third cavity, and the fluid can enter the fourth cavity from the third cavity or enter the third cavity from the fourth cavity through the second channel. In some preferred manners, the second channel is located at the bottom of the third cavity, so that the sample entering the third cavity can naturally flow into the fourth cavity under the action of its own gravity.

在一些优选的方式中，第四腔和第三腔之间的第二通道可以被封闭，当第二通道被封闭时，第四腔和第三腔处于液体隔断状态，例如，在一些优选的方式中，样本首先进入第三腔，并可沿前述的第二通道流入第四腔，第四腔内的液体可以在外力作用下进入到检测区域内，在一些优选的方式中，第四腔和检测区域处于液体连通的状态时，第二通道可以被封闭。In some preferred ways, the second channel between the fourth cavity and the third cavity can be closed, and when the second channel is closed, the fourth cavity and the third cavity are in a state of liquid isolation, for example, in some preferred In the method, the sample first enters the third chamber, and can flow into the fourth chamber along the aforementioned second channel, and the liquid in the fourth chamber can enter the detection area under the action of external force. In some preferred methods, the fourth chamber When in fluid communication with the detection area, the second channel may be closed.

本实用新型的第五方面，本实用新型提供用于盖合样本收集口的盖体。在一些优选的方式中，盖体可以作为整个装置的密封元件。在一些优选的方式中，盖体可以盖合在样本收集装置的样本收集口上。In a fifth aspect of the present invention, the present invention provides a cover body for covering the sample collection port. In some preferred ways, the cover can act as a sealing element for the entire device. In some preferred manners, the cover body can be closed on the sample collection port of the sample collection device.

如前所述，第二腔可以和第一腔处于液体连通的状态，那么第二腔与第一腔之间会有一个位置和配合关系。在一些优选的方式中，第二腔和第一腔可以结合或者而分离。在一些优选的方式中，第二腔和第三腔可以结合或者分离。As mentioned above, the second cavity may be in a state of liquid communication with the first cavity, so there will be a position and a matching relationship between the second cavity and the first cavity. In some preferred ways, the second cavity and the first cavity can be combined or separated. In some preferred ways, the second cavity and the third cavity can be combined or separated.

在一些优选的方式中，第二腔装配在盖体上。在一些优选的方式中，第二腔与盖体可拆式连接。在一些优选的方式中，盖体上设有第二腔的装配通道。在一些优选的方式中，第二腔与装配通道可拆式连接。在一些优选的方式中，装配通道可以被封闭。In some preferred modes, the second cavity is fitted on the cover. In some preferred manners, the second cavity is detachably connected to the cover. In some preferred manners, the cover body is provided with an assembly channel of the second cavity. In some preferred manners, the second cavity is detachably connected to the assembly channel. In some preferred ways, the assembly channel can be closed.

在一些优选的方式中，盖体可以装配到第三腔上。在一些优选的方式中，当盖体与第三腔盖合时，第二腔随之与第一腔实现液体连通。在一些优选的方式中，当盖体与第三腔盖合时，连通器刺破第二腔使第一腔与第二腔实现液体连通。在一些优选的方式中，当盖体与第三腔盖合时，装配通道与第一通道结合并将第一通道封闭，使第三腔和第一腔处于液体隔断状态。In some preferred manners, the cover may fit onto the third cavity. In some preferred manners, when the cover body is closed with the third cavity, the second cavity is then in liquid communication with the first cavity. In some preferred manners, when the cover body is closed with the third cavity, the communicating device pierces the second cavity to realize liquid communication between the first cavity and the second cavity. In some preferred manners, when the cover body is closed with the third cavity, the assembly channel is combined with the first channel and the first channel is closed, so that the third cavity and the first cavity are in a state of liquid isolation.

在一些优选的方式中，盖体可以装配到第一腔上。在一些优选的方式中，当盖体与第一腔盖合时，第二腔随之与第一腔实现液体连通。在一些优选的方式中，当盖体与第一腔盖合时，连通器刺破第二腔使第一腔与第二腔实现液体连通。In some preferred modes, the cover can be fitted over the first cavity. In some preferred manners, when the cover body is closed with the first cavity, the second cavity is then in liquid communication with the first cavity. In some preferred manners, when the cover body is closed with the first cavity, the communicating device pierces the second cavity to realize liquid communication between the first cavity and the second cavity.

本实用新型的第五方面，本实用新型提供一种第二腔的装配结构，装配结构能够与盖体内的通道配合，将第二腔装入盖体或者从中取出。在一些优选的方式中，装配结构与盖体可拆式的结合或连接。在一些优选的方式中，可拆式的结合是螺纹连接。在一些优选的方式中，可拆式的结合是插接配合。In a fifth aspect of the present invention, the present invention provides an assembling structure of the second cavity, which can cooperate with the channel in the cover body, and the second cavity can be loaded into the cover body or taken out from the cover body. In some preferred manners, the assembly structure is detachably combined or connected with the cover. In some preferred manners, the detachable connection is a threaded connection. In some preferred forms, the releasable coupling is a plug fit.

在一些优选的方式中，装配结构能够将第二腔固定其中。在一些优选的方式中，装配结构具有一个便于该装配结构和盖体进行结合或者分离的把手元件。在一些优选的方式中，装配结构具有一个便于该装配结构和盖体进行结合或者分离的旋钮元件。无论是把手元件还是旋钮元件，其作用都是为了便于使装配结构和盖体进行结合或者分离。在一些优选的方式中，当装配结构和盖体分离后，可以用塞子塞住盖体。在一些优选的方式中，在装配结构和盖体装配前，可以用塞子塞住盖体，防止盖体内用于容纳装配结构的空间掉入灰尘或者被污染。In some preferred modes, the mounting structure is capable of securing the second cavity therein. In some preferred modes, the mounting structure has a handle element that facilitates coupling or separation of the mounting structure and the cover. In some preferred manners, the mounting structure has a knob element that facilitates the coupling or separation of the mounting structure and the cover. Whether it is the handle element or the knob element, its function is to facilitate the combination or separation of the assembly structure and the cover. In some preferred manners, after the assembly structure and the cover are separated, the cover can be plugged with a plug. In some preferred manners, before the assembly structure and the cover body are assembled, the cover body may be plugged with a plug to prevent the space in the cover body for accommodating the assembly structure from falling into dust or being polluted.

在一些优选的方式中，装配结构上设有一些镂空结构，通过这些镂空的部分能够对第二腔施加一定的外力，例如挤压，使其中的样本流出。In some preferred manners, the assembly structure is provided with some hollow structures, and a certain external force, such as extrusion, can be applied to the second cavity through these hollow parts, so that the sample in the cavity flows out.

本实用新型的第六方面，本实用新型提供一种连通器，连通器用于连通第一腔或者第二腔或者使第一腔和第二腔之间实现液体连通。在一些优选的方式中，连通器本身也具有一个腔室(可以称之为连通腔)。在一些优选的方式中，连通器在连通第一腔的时候，其内部的腔室和第一腔液体连通。在一些优选的方式中，连通器在连通第二腔的时候，连通器内部的连通腔和第二腔液体连通。在一些优选的方式中，连通器内部的连通腔和第一腔以及第二腔均液体连通。In a sixth aspect of the present utility model, the present utility model provides a communicating device, which is used to communicate the first cavity or the second cavity or to realize liquid communication between the first cavity and the second cavity. In some preferred manners, the connector itself also has a chamber (which may be referred to as a communication chamber). In some preferred manners, when the communicating device communicates with the first cavity, the chamber inside the communicating device is in liquid communication with the first cavity. In some preferred manners, when the communicating device communicates with the second cavity, the communicating cavity inside the communicating device is in liquid communication with the second cavity. In some preferred manners, the communication cavity inside the connector is in liquid communication with the first cavity and the second cavity.

在一些优选的方式中，连通器与第二腔能够结合或者分离。在一些优选的方式中，连通器以刺破第二腔的方式与第二腔液体连通。在一些优选的方式中，连通器和第二腔分离后，第二腔自然闭合。在一些优选的方式中，连通器和第二腔可拆式的结合。In some preferred ways, the connector and the second cavity can be combined or separated. In some preferred manners, the connector is in fluid communication with the second chamber in a manner of piercing the second chamber. In some preferred manners, the second cavity is naturally closed after the communication device is separated from the second cavity. In some preferred manners, the connector and the second chamber are detachably combined.

在一些优选的方式中，连通器可以直接被安装在第一通道上。在一些优选的方式中，连通器可以随着盖体被安装在第一通道上。在一些优选的方式中，连通器与盖体上的装配通道可拆式的连接或者结合。在一些优选的方式中，连通器可以被安装在装配通道上，此时连通器与盖体可以同步活动，随着盖体的盖合，连通器可以罩设在第一通道上。在一些优选的方式中，需要被第二腔收集的样本可以从第一通道进入连通器，再由连通器进入第二腔。In some preferred ways, the connector may be installed directly on the first channel. In some preferred manners, the connector may be installed on the first channel along with the cover. In some preferred manners, the connector is detachably connected or combined with the assembly channel on the cover body. In some preferred manners, the communicating connector can be installed on the assembly channel, and at this time, the communicating connector and the cover body can move synchronously, and the communicating connector can be covered on the first channel as the cover body is closed. In some preferred manners, the sample that needs to be collected by the second chamber can enter the communicating device from the first channel, and then enter the second chamber through the communicating device.

在一些优选的方式中，连通器通过第一通道连通第一腔。在一些优选的方式中，连通器在连通第一腔时，能够使第一通道和第三腔处于液体隔断状态。In some preferred manners, the connector communicates with the first cavity through the first passage. In some preferred manners, when the communicating device communicates with the first cavity, the first channel and the third cavity can be in a liquid blocking state.

本实用新型的第七方面，本实用新型提供一种用于收集二次确认检测样本的第二腔，第二腔用于收集和存放二次确认检测的样本。在一些优选的方式中，第二腔从第一腔中获取样本。在一些优选的方式中，第二腔能够自然密封。在一些优选的方式中，第二腔在收集到足够量的样本后，能够被密封。在一些优选的方式中，第二腔的体积可变。在一些优选的方式中，第二腔可以是柔性腔体。在一些优选的方式中，第二腔在被装入样本前可以是真空状态。在一些优选的方式中，第二腔可以通过橡胶塞密封。在一些优选的方式中，连通器可以刺破橡胶塞，当连通器撤去后，橡胶塞可以在一定压力条件下内保持密封，从而使第二腔具有密封和存储液体样本的功能。In a seventh aspect of the present invention, the present invention provides a second cavity for collecting samples for secondary confirmation testing, and the second cavity is used for collecting and storing samples for secondary confirmation testing. In some preferred modes, the second chamber obtains the sample from the first chamber. In some preferred ways, the second cavity can be naturally sealed. In some preferred manners, the second chamber can be sealed after a sufficient amount of sample has been collected. In some preferred forms, the volume of the second cavity is variable. In some preferred forms, the second cavity may be a flexible cavity. In some preferred modes, the second chamber may be in a vacuum state before being loaded with the sample. In some preferred ways, the second cavity may be sealed by a rubber plug. In some preferred manners, the connector can pierce the rubber stopper, and when the connector is removed, the rubber stopper can remain sealed under a certain pressure, so that the second chamber has the function of sealing and storing the liquid sample.

在一些优选的方式中，第二腔直接与第一腔可拆式结合或连接。在一些优选的方式中，第二腔通过盖体与第一腔可拆式结合或者连接。在一些优选的方式中，第二腔通过装配结构与盖体可拆式结合或者连接。In some preferred manners, the second cavity is directly detachably combined or connected with the first cavity. In some preferred manners, the second cavity is detachably combined or connected with the first cavity through the cover body. In some preferred manners, the second cavity is detachably combined or connected with the cover body through an assembly structure.

在一些优选的方式中，第二腔与装配结构可拆式连接。在一些优选的方式中，第二腔可以被放入装配结构内。在一些优选的方式中，装配结构上设有一些镂空结构，通过这些镂空的部分能够对第二腔施加一定的外力，例如挤压，使其中的样本流出。在一些优选的方式中，第二腔具有一个开口，这个开口在没有受到压力作用的情况下，或者在一定压力范围内可以保持闭合状态，使第二腔内能够存放一定量的样本，这些样本的液压不足以打开这个开口，同时这个开口在受到足够大压力的情况下可以打开使第二腔与外部或者其他腔体实现液体连通，足够大的压力，例如挤压或者其他方式的压迫。In some preferred manners, the second cavity is detachably connected to the assembly structure. In some preferred modes, the second cavity may be placed into the assembly structure. In some preferred manners, the assembly structure is provided with some hollow structures, and a certain external force, such as extrusion, can be applied to the second cavity through these hollow parts, so that the sample in the cavity flows out. In some preferred manners, the second chamber has an opening, and the opening can remain closed under the condition of no pressure, or within a certain pressure range, so that a certain amount of samples can be stored in the second chamber. The hydraulic pressure is not enough to open the opening, and at the same time, the opening can be opened under the condition of sufficient pressure, so that the second cavity can be in liquid communication with the outside or other cavity, and the pressure is large enough, such as extrusion or other compression.

在一些优选的方式中，第二腔可以是硬质腔体。在一些优选的方式中，第二腔可以是柔性腔体。在一些优选的方式中，第二腔在被装入样本后其形状和体积会发生改变。在一些优选的方式中，第二腔可以被配置为内压较小，例如，其内压小于第一腔或者第三腔，这样，压差所产生的推动力或者负压或者真空所产生的吸引力可以将第一腔或者第三腔内的样本转移到第二腔内。在一些优选的方式中，可以将第二腔设置为真空，在第一腔和第二腔能够液体连通的情况下，液体可能就会由于压差的作用从第一腔流向第二腔。在一些优选的方式中，第二腔不一定要完全真空，只要使第二腔的内压小于第一腔，也可以实现上述的压差作用。在一些优选的方式中，可以对第一腔进行增压，也能够实现上述的压差作用。In some preferred ways, the second cavity may be a hard cavity. In some preferred forms, the second cavity may be a flexible cavity. In some preferred modes, the shape and volume of the second cavity changes after being loaded with the sample. In some preferred manners, the second chamber can be configured to have a lower internal pressure, for example, its internal pressure is lower than that of the first chamber or the third chamber, so that the driving force generated by the pressure difference or the negative pressure or vacuum generated The attractive force can transfer the sample in the first chamber or the third chamber into the second chamber. In some preferred manners, the second chamber can be set as a vacuum, and under the condition that the first chamber and the second chamber can be in liquid communication, the liquid may flow from the first chamber to the second chamber due to the pressure difference. In some preferred manners, the second chamber does not have to be completely evacuated, as long as the internal pressure of the second chamber is lower than that of the first chamber, the above-mentioned pressure difference effect can also be achieved. In some preferred manners, the first chamber can be pressurized, and the above-mentioned pressure difference effect can also be achieved.

本实用新型的第八方面，本实用新型提供移液元件，移液元件能够使第一腔内的液体向第二腔内转移。在一些优选的方式中，移液元件能够使第四腔内的液体向检测区域转移。In an eighth aspect of the present invention, the present invention provides a pipetting element, which can transfer the liquid in the first cavity to the second cavity. In some preferred manners, the pipetting element is capable of transferring the liquid in the fourth chamber to the detection area.

在一些优选的方式中，移液元件包括用于将第一腔内的样本转移到第二腔内的第一移液元件，以及，将第四腔内的样本转移到检测区域的第二移液元件。在一些优选的方式中，第一移液元件能够在外力作用下移动从而挤压第一腔内的样本，对其产生压力，使其向所需要的方向或者腔室进行转移。在一些优选的方式中，第二移液元件能够在外力作用下移动从而挤压第四腔体内的样本，对其产生压力，使其向所需要的方向或者腔室进行转移。In some preferred manners, the pipetting element comprises a first pipetting element for transferring the sample in the first chamber to the second chamber, and a second pipetting element for transferring the sample in the fourth chamber to the detection area liquid components. In some preferred manners, the first pipetting element can move under the action of an external force so as to squeeze the sample in the first chamber and generate pressure to transfer it to a desired direction or chamber. In some preferred manners, the second pipetting element can move under the action of an external force so as to squeeze the sample in the fourth chamber to generate pressure to transfer it to a desired direction or chamber.

在一些优选的方式中，第一移液元件和第一腔处于同一移液通道内，推动第一移液元件可以实现上述的挤压。在一些优选的方式中，第二移液元件和第四腔处于同一移液通道内，推动第二移液元件可以实现上述的挤压。在一些优选的方式中，第一移液元件、第二移液元件、第一腔和第四腔处于同一移液通道内，推动第一移液元件或第二移液元件其中之一可以同时实现上述的挤压，在这种情况下，第一移液元件和第二移液元件可以实现逐级联动的状态，例如在第一移液元件被推动的情况下，第一移液元件首先受力移动，挤压第一腔内的样本，第二移液元件移动的阻力可能大于第一腔内液体被移动的阻力，此时第一腔内的样本优先被转移，当第一腔内的样本被排出至第一移液元件对第二移液元件的作用力大于第二移液元件移动的阻力时，第二移液元件开始挤压第四腔内的样本，使得第四腔内的样本也被转移，或者，在另一些可能的情况下，第二移液元件被推动，第二移液元件首先受力移动并挤压第四腔内的样本，此时，第一移液元件移动的阻力可能大于第四腔内液体被移动的阻力，第四腔内的样本优先被转移，当第四腔内的样本被排出至第二移液元件对第一移液元件的作用力大于第一移液元件移动的阻力时，第一移液元件开始挤压第一腔内的样本，使得第一腔内的样本也被转移。在有些情况下，我们希望，当第一移液元件和第二移液元件在如前所述的联动状态下，第一腔内的液体优先被转移。In some preferred manners, the first pipetting element and the first cavity are in the same pipetting channel, and the above-mentioned squeezing can be achieved by pushing the first pipetting element. In some preferred manners, the second pipetting element and the fourth cavity are in the same pipetting channel, and pushing the second pipetting element can realize the above-mentioned squeezing. In some preferred manners, the first pipetting element, the second pipetting element, the first cavity and the fourth cavity are in the same pipetting channel, and one of the first pipetting element or the second pipetting element can be pushed simultaneously To achieve the above-mentioned squeezing, in this case, the first pipetting element and the second pipetting element can achieve a state of step-by-step linkage, for example, when the first pipetting element is pushed, the first pipetting element first It is moved by force and squeezes the sample in the first chamber. The resistance of the second pipetting element to move may be greater than the resistance of the liquid in the first chamber to be moved. At this time, the sample in the first chamber is preferentially transferred. When the sample is discharged to the first pipetting element, the force on the second pipetting element is greater than the resistance of the second pipetting element to move, the second pipetting element begins to squeeze the sample in the fourth chamber, so that the fourth chamber The sample of the The resistance of the element to move may be greater than the resistance of the liquid in the fourth chamber to be moved, and the sample in the fourth chamber is preferentially transferred. When the sample in the fourth chamber is discharged to the second pipetting element, the force on the first pipetting element When the resistance of the movement of the first pipetting element is greater than that of the first pipetting element, the first pipetting element begins to squeeze the sample in the first chamber, so that the sample in the first chamber is also transferred. In some cases, it is desirable that the liquid in the first chamber be preferentially transferred when the first pipetting element and the second pipetting element are in the linked state as described above.

在一些优选的方式中，移液通道与第二腔可以实现液体连通或隔断。在一些优选的方式中，移液通道与检测区域可以实现液体连通或隔断。在一些优选的方式中，第一移液元件和第二移液元件将移液通道移液通道分隔为第一腔和第四腔。在一些优选的方式中，第二移液元件将第四腔和第二腔隔断。In some preferred manners, the pipetting channel and the second cavity can achieve liquid communication or isolation. In some preferred manners, the pipetting channel and the detection area can be in liquid communication or isolation. In some preferred manners, the first pipetting element and the second pipetting element divide the pipetting channel into a first cavity and a fourth cavity. In some preferred manners, the second pipetting element separates the fourth chamber from the second chamber.

在一些优选的方式中，当第一腔内的样本被转移到第二腔内时，第一腔的体积随之缩小。在一些优选的方式中，当第一腔的体积缩小时，第一移液元件和第二移液元件随之靠拢。在一些优选的方式中，当第四腔内的样本被转移到测试区域内时，第四腔的体积随之缩小。在一些优选的方式中，当第一腔内的液体被转移后，第一腔和第二腔之间的液体连通状态被隔断。在一些优选的方式中，当第四腔内的液体被转移时，第四腔和第三腔之间的液体连通状态被隔断。在一些优选的方式中，第四腔和第三腔的连通状态被隔断是通过第二移液元件在移动过程中封闭第二通道来实现的。In some preferred manners, when the sample in the first chamber is transferred into the second chamber, the volume of the first chamber decreases accordingly. In some preferred manners, when the volume of the first cavity decreases, the first pipetting element and the second pipetting element move closer together. In some preferred manners, when the sample in the fourth chamber is transferred into the testing area, the volume of the fourth chamber decreases accordingly. In some preferred manners, after the liquid in the first cavity is transferred, the liquid communication state between the first cavity and the second cavity is blocked. In some preferred manners, when the liquid in the fourth cavity is transferred, the liquid communication state between the fourth cavity and the third cavity is blocked. In some preferred manners, the communication state of the fourth chamber and the third chamber is blocked by closing the second channel during the movement of the second pipetting element.

在一些优选的方式中，第四腔的初始体积固定，也就是说，在第四腔受力被压缩之前，第四腔内能够装入的样本的量是可以确定的。在一些优选的方式中，第二移液元件在移液通道内的初始位置固定。在一些优选的方式中，第一腔的初始体积固定，也就是说，在第一腔受力被压缩之前，第一腔内能够装入的样本的量是可以确定的。在一些优选的方式中，第一移液元件在移液通道内的初始位置固定。在一些优选的方式中，第一移液元件和第二移液元件在移液通道内的相对初始位置固定。In some preferred manners, the initial volume of the fourth cavity is fixed, that is, before the fourth cavity is compressed by force, the amount of the sample that can be loaded into the fourth cavity can be determined. In some preferred manners, the initial position of the second pipetting element within the pipetting channel is fixed. In some preferred manners, the initial volume of the first cavity is fixed, that is, before the first cavity is compressed by force, the amount of the sample that can be loaded into the first cavity can be determined. In some preferred manners, the initial position of the first pipetting element within the pipetting channel is fixed. In some preferred manners, the relative initial positions of the first pipetting element and the second pipetting element in the pipetting channel are fixed.

在一些优选的方式中，移液通道具有一个移液开口，通过移液开口可以向移液通道内施加外力，实现上述的挤压。在一些优选的方式中，移液开口可以被第一移液元件或第二移液元件所密封。在一些优选的方式中，移液元件还包括能够推动第一移液元件和/或第二移液元件的移液塞。在一些优选的方式中，移液塞能够通过移液开口伸入移液通道内。在一些优选的方式中，移液通道的开口被在一些优选的方式中，第一移液元件和/或第二移液元件上设有与移液塞匹配的插口。In some preferred manners, the pipetting channel has a pipetting opening, and an external force can be applied to the pipetting channel through the pipetting opening to realize the above-mentioned squeezing. In some preferred ways, the pipetting opening can be sealed by the first pipetting element or the second pipetting element. In some preferred manners, the pipetting element further comprises a pipetting plug capable of pushing the first pipetting element and/or the second pipetting element. In some preferred modes, the pipette plug is capable of extending into the pipetting channel through the pipetting opening. In some preferred ways, the opening of the pipetting channel is defined. In some preferred ways, the first pipetting element and/or the second pipetting element is provided with a socket matching the pipetting plug.

在一些优选的方式中，移液元件和移液通道之间设有密封元件，确保移液元件在移液通道内移动时，不会发生样本从移液元件和移液通道的内壁之间泄露的情况。In some preferred manners, a sealing element is provided between the pipetting element and the pipetting channel to ensure that the sample will not leak from between the pipetting element and the inner wall of the pipetting channel when the pipetting element moves in the pipetting channel Case.

本实用新型的第九方面，本实用新型提供一种收集液体样本的方法，该方法采用如前所述的样本收集装置，该样本收集装置包括用于收集液体样本的第一腔和用于收集确认检测样本的第二腔，第一腔和第二腔能够处于液体连通或隔断的状态，当第一腔和第二腔处于液体连通状态时，第一腔内的液体能够被转移到第二腔内。In a ninth aspect of the present invention, the present invention provides a method for collecting liquid samples. The method adopts the sample collecting device as described above. The sample collecting device includes a first cavity for collecting liquid samples and a Confirm that the second cavity of the test sample, the first cavity and the second cavity can be in a state of liquid communication or isolation, when the first cavity and the second cavity are in a liquid communication state, the liquid in the first cavity can be transferred to the second cavity intracavity.

在一些优选的方式中，还包括用于收集样本的第三腔，第三腔和第一腔能够与第一腔处于液体连通或隔断的状态，可以通过第三腔进行初始样本的收集，第一腔内所收集到的样本，可能会被转移到第二腔内用于二次检测用途。In some preferred manners, it also includes a third chamber for collecting samples, the third chamber and the first chamber can be in a state of liquid communication or isolation with the first chamber, and the initial sample collection can be performed through the third chamber, and the first Samples collected in one chamber may be transferred to the second chamber for secondary testing purposes.

在一些优选的方式中，当第一腔和第三腔处于液体连通状态时，第三腔内收集的液体能够同时进入第一腔，也就是说在第三腔进行样本初始收集的时候，第一腔内同时也能够装入初始收集的样本。In some preferred manners, when the first chamber and the third chamber are in liquid communication state, the liquid collected in the third chamber can enter the first chamber at the same time, that is to say, when the third chamber performs initial sample collection, the A chamber can also hold the initially collected sample.

在一些优选的方式中，当第一腔内的液体被转入第二腔内时，第一腔和第三腔处于液体隔断状态，由于第二腔内的样本是用于二次确认检测，为了确保第二腔内的样本不被污染，在转移之前就将第一腔与其他的腔室进行隔离。In some preferred manners, when the liquid in the first chamber is transferred into the second chamber, the first chamber and the third chamber are in a state of liquid isolation, since the sample in the second chamber is used for secondary confirmation detection, To ensure that the samples in the second chamber are not contaminated, the first chamber is isolated from the other chambers prior to transfer.

在一些优选的方式中，还包括用于收集待检测样本的第四腔，第四腔能够与第三腔处于液体连通或隔断的状态。In some preferred manners, a fourth chamber for collecting samples to be detected is further included, and the fourth chamber can be in a state of liquid communication or isolation with the third chamber.

在一些优选的方式中，当第四腔与第三腔处于液体连通状态时，第三腔内收集的液体能够同时进入第四腔，第四腔也可以与第三腔在初始收集样本的时候就处于连通的状态，这样第四腔也可以和第三腔基本上同步地完成所需要的样本，第四腔内所收集到的样本主要用于初次检测，初次检测可以直接在第四腔内进行，也可以通过第四腔转移到其他区域进行，例如检测区域。In some preferred manners, when the fourth chamber and the third chamber are in liquid communication state, the liquid collected in the third chamber can enter the fourth chamber at the same time, and the fourth chamber can also be connected with the third chamber when the sample is initially collected. It is in a connected state, so that the fourth chamber can also complete the required samples basically synchronously with the third chamber. The samples collected in the fourth chamber are mainly used for the initial detection, and the initial detection can be directly in the fourth chamber. It can also be transferred to other areas through the fourth chamber, such as the detection area.

在一些优选的方式中，还包括检测区域，第四腔能够与检测区域处于液体连通或隔断的状态，当第四腔在初始收集的时候，第四腔与检测区域可以被隔离开来，也就是说，收集和检测可以是相互独立的环节。In some preferred manners, a detection area is also included, and the fourth chamber can be in a state of liquid communication or isolation with the detection area. When the fourth chamber is initially collected, the fourth chamber can be isolated from the detection area, and also That is, collection and detection can be separate links.

在一些优选的方式中，当第四腔与检测区域处于液体连通状态时，第四腔和第三腔处于液体隔断状态，一方面可以确保检测区域不被其他腔室可能造成的污染影响，另一方面可以实现定量检测，只要设定第四腔的体积，就可以实现对进入检测区域的样本的定量。In some preferred ways, when the fourth chamber and the detection area are in liquid communication state, the fourth chamber and the third chamber are in a liquid isolation state, on the one hand, it can ensure that the detection area is not affected by possible contamination caused by other chambers, and on the other hand On the one hand, quantitative detection can be achieved. As long as the volume of the fourth chamber is set, the quantitative detection of the sample entering the detection area can be achieved.

在一些优选的方式中，第二腔和第三腔能够结合或者分离。在一些优选的方式中，第二腔和第一腔能够结合或者分离。由于第二腔是需要从第一腔或者第三腔获取到所收集的样本的，因此第二腔必须和第一腔或者第三腔或者其中之一建立液体连通的关系，当获取到了所需的样本之后，第二腔又必须要能够独立密封并保存其中的腔体，甚至要被独立进行运输，送往二次检测机构，因此第二腔有必须要和第一腔或者第三腔或者其中之一分离，在一些优选的方式中，第二腔可以和第一腔或者第三腔或者其中之一可拆式的结合或者连接。In some preferred ways, the second cavity and the third cavity can be combined or separated. In some preferred ways, the second cavity and the first cavity can be combined or separated. Since the second chamber needs to acquire the collected sample from the first chamber or the third chamber, the second chamber must establish a liquid communication relationship with the first chamber or the third chamber or one of them. After the sample is collected, the second chamber must be able to independently seal and store the chambers in it, and even be transported independently and sent to the secondary detection mechanism, so the second chamber must One of them is separated, and in some preferred manners, the second cavity can be detachably combined or connected with the first cavity or the third cavity or one of them.

在一些优选的方式中，还包括第一腔和第二腔之间的连通装置，连通装置为第一腔内的样本进入到第二腔内提供了一个较为便利的渠道和路径。In some preferred manners, a communication device between the first cavity and the second cavity is also included, and the communication device provides a relatively convenient channel and path for the sample in the first cavity to enter the second cavity.

在一些优选的方式中，在初始收集样本的时候，连通装置并没有安装到位，需要进行二次确认收集的时候，再安装连通装置。In some preferred manners, when the sample is initially collected, the communication device is not installed in place, and the communication device is installed when a secondary confirmation collection is required.

在一些优选的方式中，连通装置可以让第一腔和第二腔处于液体连通的状态也可以将第一腔和第二腔的连通状态隔断。In some preferred manners, the communication device can keep the first cavity and the second cavity in a state of liquid communication, and can also block the communication state of the first cavity and the second cavity.

在一些优选的方式中，连通装置可以将第一腔和第三腔的连通状态隔断。当初始样本的收集完成后，为了确保二次确认样本的无污染，可以先将第一腔和第三腔进行隔断。In some preferred manners, the communication device can block the communication state of the first cavity and the third cavity. When the collection of the initial sample is completed, in order to ensure the non-contamination of the second confirmation sample, the first chamber and the third chamber can be separated first.

在本实用新型中，由于初始收集到的样本无法自然进入到第二腔内，必须要通过一定的外力作用下，在这种情况下，就必须要对初始收集到的样本采取一定的作用力。In the present invention, since the initially collected sample cannot enter the second cavity naturally, it must be acted by a certain external force. In this case, a certain force must be applied to the initially collected sample .

因此，在一些优选的方式中，本实用新型的方法还提供一种移液元件，在初始收集完成后，第一腔内已经有足够量的样本，那么此时推动移液元件，对第一腔内的样本进行挤压，使其直接或者通过连通装置进入到第二腔内，于此同时，第一腔本身的体积被压缩。在一些优选的方式中，移液元件也可以对第四腔内的样本进行转移。在一些优选的方式中，第四腔内样本的转移可以在第一腔内样本转移之后。在一些优选的方式中，第一腔和第四腔可以分别采用不同的移液元件进行挤压。在一些优选的方式中，第一腔和第四腔的移液元件之间可以实现联动。Therefore, in some preferred manners, the method of the present invention also provides a pipetting element. After the initial collection is completed, there is already a sufficient amount of samples in the first chamber, and then the pipetting element is pushed at this time, and the first chamber has a sufficient amount of samples. The sample in the cavity is squeezed into the second cavity directly or through the communication device, and at the same time, the volume of the first cavity itself is compressed. In some preferred manners, the pipetting element can also transfer the sample in the fourth chamber. In some preferred manners, the transfer of the sample in the fourth chamber may follow the transfer of the sample in the first chamber. In some preferred manners, the first cavity and the fourth cavity can be squeezed with different pipetting elements respectively. In some preferred manners, linkage can be achieved between the pipetting elements of the first chamber and the fourth chamber.

在一些优选的方式中，本实用新型的方法还提供移液通道，上述的移液元件能够在移液通道内进行移动，从而对第一腔或第四腔内的液体进行挤压。在一些优选的方式中，第一腔或第四腔可以是移液通道内的某一段，通过不同的移液元件将其分隔开来形成腔体。在一些优选的方式中，第一腔可以和第二腔实现液体连通。在一些优选的方式中，第四腔可以和检测区域实现液体连通。也就是说，作为移液通道本身就可以和第二腔或者检测区域或者二者连通。In some preferred manners, the method of the present invention further provides a pipetting channel, and the above-mentioned pipetting element can move in the pipetting channel, so as to squeeze the liquid in the first cavity or the fourth cavity. In some preferred manners, the first cavity or the fourth cavity may be a certain section in the pipetting channel, which is separated by different pipetting elements to form a cavity. In some preferred manners, the first cavity can be in fluid communication with the second cavity. In some preferred manners, the fourth chamber can be in liquid communication with the detection area. That is to say, the pipetting channel itself can communicate with the second chamber or the detection area or both.

在一些优选的方式中，本实用新型的方法还提供一种移液塞，移液塞主要是用于向移液元件提供移动的动力，使其在移液通道内移动从而对第一腔和/或第四腔内的样本产生挤压的力，使这些样本进行转移。In some preferred manners, the method of the present invention also provides a pipetting plug, which is mainly used to provide moving power to the pipetting element, so that it moves in the pipetting channel so as to affect the first cavity and the /or the samples in the fourth chamber generate a squeezing force to transfer these samples.

在一些优选的方式中，本实用新型的方法还提供移液元件和移液通道之间的密封结构，确保在移液元件受力移动时，其与移液通道的内壁之间不会产生缝隙，不会发生样本泄露。In some preferred manners, the method of the present invention also provides a sealing structure between the pipetting element and the pipetting channel to ensure that when the pipetting element is forced to move, no gap will be created between it and the inner wall of the pipetting channel , no sample leakage will occur.

本实用新型的第十方面，本实用新型提供一种检测液体样本中是否存在被分析物质的方法，所述检测方法包括上述的任意一种方式的样本收集装置，通过样本收集装置收集待检测的样本，待第四腔内收集有样本后，对其中的样本进行检测。在一些优选的方式中，待第三腔内收集有样本后，对其中的样本进行检测。在一些优选的方式中，将第四腔内的样本转移到检测区域对其进行检测。在一些优选的方式中，将第三腔内的样本转移到检测区域对其进行检测。等获得检测结果后，让第二腔按照上述任意的方式与样本收集装置进行分离。In a tenth aspect of the present invention, the present invention provides a method for detecting whether a substance to be analyzed exists in a liquid sample. The detecting method includes any one of the above-mentioned sample collection devices. After the sample is collected in the fourth cavity, the sample in it is tested. In some preferred manners, after the sample is collected in the third chamber, the sample in the third chamber is detected. In some preferred manners, the sample in the fourth chamber is transferred to the detection area for detection. In some preferred manners, the sample in the third chamber is transferred to the detection area for detection. After the detection results are obtained, the second chamber is separated from the sample collection device in any of the above-mentioned manners.

本实用新型的有益效果是：采用本实用新型的结构，具有结构简单合理的特点，使用材料成本低廉，性能优良；便于二次检测。特别的，当需要进行后续的确认检测的时候，不需要把整个检测装置送往测试机构进行检测，而仅仅是从装置中取下第二腔，然后送往检测结构，这样不仅安全，而且节约空间，节约成本，更加环保。The beneficial effects of the utility model are: adopting the structure of the utility model has the characteristics of simple and reasonable structure, low cost of materials used, excellent performance, and is convenient for secondary detection. In particular, when subsequent confirmation testing is required, the entire testing device does not need to be sent to the testing mechanism for testing, but only the second cavity is removed from the device and sent to the testing structure, which is not only safe, but also saves money Space, cost saving and more environmentally friendly.

附图说明Description of drawings

图1是一个具体实施方式中样本检测装置的整体结构图。FIG. 1 is an overall structural diagram of a sample detection device in a specific embodiment.

图2是一个具体实施方式中样本检测装置的局部爆炸图，图中盖体处于打开状态，移液塞未被塞入。FIG. 2 is a partial exploded view of the sample detection device in a specific embodiment, in which the cover is in an open state and the pipette plug is not inserted.

图3是一个具体实施方式中盖体的示意图，此时第二腔和连通器已装配到盖体上。Figure 3 is a schematic view of the cover in one embodiment, with the second cavity and the connector assembled to the cover.

图4是图3所示的盖体从另一个角度的示意图。FIG. 4 is a schematic view of the cover shown in FIG. 3 from another angle.

图5是图3所示的盖体上部的结构图，示出装配的把手或旋钮结构。Fig. 5 is a structural view of the upper part of the cover shown in Fig. 3, showing the assembled handle or knob structure.

图6是一个具体实施方式中盖体的示意图，此时第二腔尚未装配到盖体上。FIG. 6 is a schematic view of the cover body in a specific embodiment, when the second cavity has not yet been assembled to the cover body.

图7是一个具体实施方式中第二腔和装配结构以及连通器的装配关系图。FIG. 7 is an assembly relationship diagram of the second cavity and the assembly structure and the communication connector in a specific embodiment.

图8是一个具体实施方式中第二腔和连通器的装配关系图。FIG. 8 is an assembly relationship diagram of the second chamber and the communication connector in a specific embodiment.

图9是一个具体实施方式中连通器的示意图。Figure 9 is a schematic diagram of a connector in one embodiment.

图10是一个具体实施方式中连通器的仰视图。Figure 10 is a bottom view of the connector in one embodiment.

图11是一个具体实施方式中连通器的俯视图。Figure 11 is a top plan view of a connector in one embodiment.

图12是一个具体实施方式中第二腔的示意图。Figure 12 is a schematic diagram of a second chamber in one embodiment.

图13是图12所示的第二腔的从另一个角度的示意图，从图13的角度可以看出第二腔的底部具有一个开口，该开口能够使第二腔与外部或者其他腔体实现液体连通。FIG. 13 is a schematic diagram of the second cavity shown in FIG. 12 from another angle. From the angle of FIG. 13 , it can be seen that the bottom of the second cavity has an opening, which enables the second cavity to be connected to an external or other cavity. fluid communication.

图14是图13所示的第二腔底部的开口被密封的示意图。FIG. 14 is a schematic view of the opening at the bottom of the second cavity shown in FIG. 13 being sealed.

图15是图12所示的第二腔的另一个角度的示意图，从图15中可以看出，当第二腔内未被装入样本，第二腔可以收缩为扁平的状态。Fig. 15 is a schematic view of the second cavity shown in Fig. 12 from another angle. It can be seen from Fig. 15 that when the second cavity is not loaded with a sample, the second cavity can be contracted into a flat state.

图16是一个具体实施方式中第二腔的装配结构的示意图。FIG. 16 is a schematic diagram of the assembly structure of the second cavity in one embodiment.

图17是一个具体实施方式中第二腔与装配结构结合的示意图。FIG. 17 is a schematic diagram of the combination of the second cavity and the assembly structure in one embodiment.

图18是图17中第二腔被装入样本后的示意图。FIG. 18 is a schematic view of the second chamber in FIG. 17 after the sample is loaded.

图19是一个具体实施方式中第二腔完成样本收集后与连通器分离的示意图。FIG. 19 is a schematic diagram of the separation of the second chamber from the connector after sample collection is completed in one embodiment.

图20是一个具体实施方式中第三腔的示意图，第三腔可以是一个盒体，在这个具体的实施方式中，检测区域可以设置在第三腔的一侧。20 is a schematic diagram of a third cavity in a specific embodiment, the third cavity may be a box body, and in this specific embodiment, the detection area may be arranged on one side of the third cavity.

图21是图20中的第三腔从另一个角度的示意图，从这个角度可以示出第一通道和第二通道所在的位置。Fig. 21 is a schematic view of the third chamber in Fig. 20 from another angle, from which the positions of the first and second passages can be shown.

图22是图20中的第三腔从另一个角度的示意图，从这个角度可以示出移液通道的部分结构。Fig. 22 is a schematic view of the third chamber in Fig. 20 from another angle, from which part of the structure of the pipetting channel can be shown.

图23是另一个具体实施方式中第三腔的示意图，在这个具体的实施方式中，第三腔上装配了一个密封连接盖。Figure 23 is a schematic view of a third cavity in another embodiment, in which a sealing connection cover is assembled on the third cavity.

图24是图23中所示的第三腔上的密封连接盖的示意图。FIG. 24 is a schematic view of the sealing connection cover on the third cavity shown in FIG. 23 .

图25是图24中的密封连接盖的另一个角度的示意图。FIG. 25 is a schematic view of another angle of the sealing connection cover of FIG. 24 .

图26是一个具体实施方式中第三腔的剖视图，在本图所示的状态下，第一移液元件和第二移液元件尚未安装在移液通道内。26 is a cross-sectional view of the third chamber in a specific embodiment, in the state shown in this figure, the first pipetting element and the second pipetting element have not been installed in the pipetting channel.

图27是是一个具体实施方式中移液通道的剖视图，在本图所示的状态下，第一移液元件和第二移液元件所处的位置为装置未被使用时的位置，此时第一腔和第四腔均为被压缩，第一通道与第一腔处于液体连通状态，第二通道与第四腔处于液体连通状态。27 is a cross-sectional view of a pipetting channel in a specific embodiment. In the state shown in this figure, the positions of the first pipetting element and the second pipetting element are the positions when the device is not in use. At this time Both the first cavity and the fourth cavity are compressed, the first channel and the first cavity are in a liquid communication state, and the second channel and the fourth cavity are in a liquid communication state.

图28是一个具体实施方式中移液通道的剖视图，在本图所示的状态下，第二移液元件向挤压第四腔的方向移动，同时开始对第二通道进行密封。Fig. 28 is a cross-sectional view of a pipetting channel in a specific embodiment. In the state shown in this figure, the second pipetting element moves in the direction of squeezing the fourth cavity, and simultaneously begins to seal the second channel.

图29是一个具体实施方式中第三腔的剖视图，在本图所示的状态下，第一移液元件和第二移液元件被移液塞顶至向内的极限位置，此时，第四腔和第一腔均被压缩，第四腔内的样本被推入检测区域内，第一腔内的样本被推入第二腔内，第一腔和第一通道处于液体隔断状态，第四腔和第二通道处于液体隔断状态。Fig. 29 is a cross-sectional view of the third chamber in a specific embodiment. In the state shown in this figure, the first pipetting element and the second pipetting element are pushed by the pipette plug to the limit position inward. Both the fourth cavity and the first cavity are compressed, the sample in the fourth cavity is pushed into the detection area, the sample in the first cavity is pushed into the second cavity, the first cavity and the first channel are in a liquid isolation state, and the first cavity is in a liquid isolation state. The four chambers and the second channel are in a state of liquid isolation.

图30是一个具体实施方式中移液塞的示意图。Figure 30 is a schematic illustration of a pipette stopper in one embodiment.

图31是一个具体实施方式中第一移液元件的示意图。Figure 31 is a schematic diagram of a first pipetting element in one embodiment.

图32是一个具体实施方式中第一移液元件从另一个角度的示意图。Figure 32 is a schematic view of the first pipetting element from another angle in one embodiment.

图33是一个具体实施方式中第二移液元件的示意图。Figure 33 is a schematic illustration of a second pipetting element in one embodiment.

图34是一个具体实施方式中第二移液元件从另一个角度的示意图。Figure 34 is a schematic illustration of a second pipetting element from another angle in one embodiment.

图35是一个具体实施方式中第一移液元件和第二移液元件上密封结构的示意图。Figure 35 is a schematic diagram of the sealing structure on the first pipetting element and the second pipetting element in a specific embodiment.

图36是连通器和第一通道的装配关系示意图。Fig. 36 is a schematic diagram of the assembling relationship between the communication connector and the first channel.

图37是一个具体实施方式中第一腔、第三腔和连通器的示意图。Figure 37 is a schematic diagram of a first chamber, a third chamber and a connector in one embodiment.

图中标号：第一腔41，第二腔42，第三腔43，第四腔44，检测区域45，检测入口46，第一通道47，第二通道48，收集口49，收集槽50，移液通道51，第一移液元件52，第二移液元件53，检测入口隔断件54，开口端55，开口56，密封件57，连通器58，刺破元件59，连通腔60，台阶面61，第二腔的装配结构62，盖体63，锥形面64，测试元件入口65，密封连接盖66，第一盖67，第二盖68，与盖体配合的连接部位69，装配通道70，装配结构外壁71，装配结构内腔72，镂空结构73，固定环74，装配连接件75，密封元件76，移液开口77，移液塞78，第一移动腔79，支撑脚80，密封槽81，第三通道82，压力孔83。Reference numerals in the figure: the first cavity 41, the second cavity 42, the third cavity 43, the fourth cavity 44, the detection area 45, the detection inlet 46, the first channel 47, the second channel 48, the collection port 49, the collection tank 50, Pipetting channel 51, first pipetting element 52, second pipetting element 53, detection inlet partition 54, open end 55, opening 56, seal 57, communication connector 58, piercing element 59, communication cavity 60, step Face 61, assembly structure 62 of the second cavity, cover body 63, tapered surface 64, test element inlet 65, sealing connection cover 66, first cover 67, second cover 68, connection part 69 that cooperates with the cover body, assembly Channel 70 , outer wall of assembly structure 71 , inner cavity of assembly structure 72 , hollow structure 73 , fixing ring 74 , assembly connecting piece 75 , sealing element 76 , pipetting opening 77 , pipetting plug 78 , first moving cavity 79 , support foot 80 , sealing groove 81 , third channel 82 , pressure hole 83 .

具体实施方式Detailed ways

以下结合附图对本实用新型做进一步的详细说明，应当指出的是，实施例只是对本实用新型的具体描述，不应视为对本实用新型的限定。The present utility model will be further described in detail below with reference to the accompanying drawings. It should be noted that the embodiments are only specific descriptions of the present utility model, and should not be regarded as a limitation of the present utility model.

首先对本实用新型涉及的结构或所使用的技术术语做进一步的说明，如果没有特别指明，按照本领域通用的一般技术术语进行理解和解释。First of all, the structure involved in the present invention or the technical terms used are further described. If there is no special indication, it is understood and explained according to the general technical terms commonly used in the art.

检测detect

检测表示化验或测试一种物质或材料是否存在，比如，但并不限于此，化学物质、有机化合物、无机化合物、新陈代谢产物、药物或者药物代谢物、有机组织或有机组织的代谢物、核酸、蛋白质或聚合物。另外，检测表示测试物质或材料的数量。进一步说，化验还表示免疫检测，化学检测、酶检测等。Detection means assaying or testing for the presence of a substance or material such as, but not limited to, chemicals, organic compounds, inorganic compounds, metabolites, drugs or drug metabolites, organic tissue or metabolites of organic tissue, nucleic acids, protein or polymer. In addition, detection refers to the quantity of a test substance or material. Further, the assay also means immunoassay, chemical assay, enzymatic assay, and the like.

确认检测Confirm detection

确认检测又可以称为二次检测、二次确认检测，当第一次检测结果显示可能为阳性或者弱阳性或者无法准确判断时，为了确保检测结果的准确性或者获得更为准确的检测结果，需要将同一批次的样本(最优是同一批次采集的)送往非现场的或者较远的具有确认检测资质的场所进行第二次检测，以验证检测结果。确认检测的目的是对现场或初次检测结果的一种确认操作，其检验的仪器可能会更为精准，检验的方法可能会更为严密，但基本的原理与初检是相同或者近似的，只是在初检基础上的复检。Confirmation testing can also be called secondary testing or secondary confirmation testing. When the first test result shows that it may be positive or weakly positive or cannot be accurately judged, in order to ensure the accuracy of the test results or obtain more accurate test results, It is necessary to send the same batch of samples (optimally collected from the same batch) to an off-site or distant place with confirmation testing qualifications for a second test to verify the test results. The purpose of the confirmation test is to confirm the results of the on-site or initial test. The test instrument may be more accurate, and the test method may be more rigorous, but the basic principle is the same or similar to the initial test, but A re-inspection based on the initial inspection.

样本sample

本实用新型的检测装置可以检测的样品包括生物液体(例如病例液体或者临床样品)。液体样品或者液体样品可以来源于固态或者半固态的样品，包括排泄物，生物组织和食品样品。利用任何适当的方法可以将固态或半固态的样品转化成液体样品，例如混合、捣碎、浸软、孵育、溶解或在合适的溶液中(例如水，磷酸盐溶液或其他缓冲溶液)利用酶解作用消化固体样品。“生物样品”包括来源于动物，植物和食品样品，例如包括来源于人或动物的尿液，唾液，血及其成分，脊髓液、阴道分泌物，精子，粪便，汗液，分泌物，组织，器官，瘤，组织和器官的培养物，细胞培养物和介质。优选生物样品是尿。食品样品包括食品加工的物质，最终产品，肉，干酪，酒，牛奶和引用水。植物样品包括源于任何植物，植物组织，植物细胞培养物和介质。“环境样品”来源于环境(例如，来自于湖或者其他水体的液体样品，污水样品，土质样品，地下水，海水和废液样品)。环境样品还可包括污水或者其他废水。The samples that can be detected by the detection device of the present invention include biological fluids (such as case fluids or clinical samples). Liquid samples or liquid samples can be derived from solid or semi-solid samples, including excreta, biological tissue and food samples. A solid or semi-solid sample can be converted to a liquid sample by any suitable method, such as mixing, mashing, macerating, incubating, dissolving or using enzymes in a suitable solution (eg water, phosphate solution or other buffer solution) Digestion of solid samples. "Biological samples" include animal, plant and food samples, including, for example, urine, saliva, blood and components thereof, spinal fluid, vaginal secretions, sperm, feces, sweat, secretions, tissues, of human or animal origin, Organs, tumors, tissues and organ cultures, cell cultures and media. Preferably the biological sample is urine. Food samples include food-processed substances, final products, meat, cheese, wine, milk and reference water. Plant samples include those derived from any plant, plant tissue, plant cell culture and media. "Environmental samples" are derived from the environment (eg, liquid samples from lakes or other bodies of water, sewage samples, soil samples, groundwater, seawater, and waste liquid samples). Environmental samples may also include sewage or other waste water.

利用本实用新型和合适的检测元件，可以检测任何被分析物。优选利用本实用新型检测唾液、尿液中的毒品小分子。当然，利用本实用新型的收集装置可以收集以上任何形式的样本，无论开始是固态的，还是液态的，只要这些液体或者液体样本流入到某一个腔室后，这些液体样本可以同时或者稍后流入其他的腔室，由于其他的腔室可以与首先流入的腔室结合或者分离，初始收集样本时，首先流入的腔室和其他的腔室结合，使用者通过一次收集动作可以完成对所需要的多个腔室的液体样本的收集，当需要进行后续确认检测时，让其中某个腔室与整体分离，从而，其中一个腔室或多个腔室内的液体样本可以进行初次检测，而被分离出去的那个腔室中的液体样本可以进行二次检测。可选的，这些腔室的功能地位也可以互换，也就是说，哪些腔室中的液体样本可以进行初次检测，哪些腔室中的液体样本可以进行二次检测是可以互换的。Using the present invention and suitable detection elements, any analyte can be detected. Preferably, the utility model is used to detect drug small molecules in saliva and urine. Of course, the collection device of the present invention can collect any of the above samples, no matter whether it is solid or liquid at first, as long as these liquids or liquid samples flow into a certain chamber, these liquid samples can flow into a certain chamber at the same time or later. For other chambers, since other chambers can be combined with or separated from the chamber that flows in first, when the sample is initially collected, the chamber that flows in first is combined with other chambers, and the user can complete the required collection through one collection action. Collection of liquid samples in multiple chambers, when subsequent confirmation testing is required, one of the chambers is separated from the whole, so that the liquid samples in one or more chambers can be tested for the first time and then separated The liquid sample in the chamber that exits can be tested a second time. Optionally, the functional status of these chambers can also be interchanged, that is, the liquid samples in which chambers can be used for primary detection and the liquid samples in which chambers can be used for secondary detection can be interchanged.

测试元件test element

测试元件可以选用横向流动的检测试纸条，它可检测多种被分析物。当然，其他合适的测试元件也可以运用在本实用新型，凡是可以检测样本或者样品是是否含有感兴趣的被分析物质的元件都可以称之为测试元件，这种检测无论是基于何种员技术原理，免疫学、化学、电学、光学，物理学等都可以。The test element can be selected as a lateral flow test strip, which can detect a variety of analytes. Of course, other suitable test elements can also be used in the present invention. Any element that can detect a sample or whether the sample contains an analyte of interest can be called a test element, no matter what kind of technology the detection is based on Principle, immunology, chemistry, electricity, optics, physics, etc.

各种测试元件可以被组合在一起运用到本实用新型中。一种形式是检测试纸。用于分析样本中的被分析物(如毒品或表明身体状况的代谢物)的检测试纸可以是各种形式，如免疫测定或化学分析的形式。检测试纸可以采用非竞争法或竞争法的分析模式。检测试纸包含一具有样本加样区的吸水材料，试剂区和测试区。加样本至样本加样区，通过毛细管作用流到试剂区。在试剂区，如果存在被分析物，样本与试剂结合。然后样本继续流动到检测区。另一些试剂，如与被分析物特异性结合的分子被固定在检测区。这些试剂与样本中的被分析物(如果存在)反应并将被分析物结合在该区，或者与试剂区的某一个试剂结合。用于显示检测信号的标记物存在与试剂区或分离的标记区。Various test elements can be combined and used in the present invention. One form is test strips. Test strips for analysis of analytes (eg, drugs or metabolites indicative of medical conditions) in a sample can be in various formats, such as in the form of immunoassays or chemical assays. The test strips can be analyzed in a non-competitive or competitive mode. The test strip includes a water-absorbing material with a sample application area, a reagent area and a test area. Add the sample to the sample application area and flow to the reagent area by capillary action. In the reagent area, the sample binds to the reagent if the analyte is present. The sample then continues to flow to the detection zone. Other reagents, such as molecules that specifically bind to the analyte, are immobilized in the detection zone. These reagents react with the analyte (if present) in the sample and bind the analyte in this zone, or bind to one of the reagents in the reagent zone. The label used to display the detection signal is present in the reagent zone or separate label zone.

典型的非竞争法分析模式是如果样本中含有被分析物，信号就会产生，如果不包含被分析物，就不产生信号。在竞争法中，如果被分析物不存在于样本中，信号产生，如果存在被分析物，则不产生信号。In a typical non-competitive assay mode, a signal is generated if the analyte is present in the sample, and no signal is generated if the analyte is not present. In the competition method, a signal is generated if the analyte is not present in the sample, and no signal is generated if the analyte is present.

测试元件是检测试纸，可以选用吸水或不吸水的材料。检测试纸可包括多种材料用于液体样本传递。其中一种检测试纸的材料可覆盖在另一种材料上，如滤纸覆盖在硝酸纤维素膜上。检测试纸的一个区可以选用一种或多种材料，而另一区选用其他不同的一种或多种材料。检测试纸可以被黏附在某种支持物或者硬质表面用于提高拿捏检测试纸的强度。The test element is a test paper, which can be made of absorbent or non-absorbent material. Test strips can include a variety of materials for liquid sample transfer. One of the test paper materials can be overlaid on another material, such as filter paper overlaid on a nitrocellulose membrane. One area of the test strip can be selected from one or more materials, while the other area can be selected from other different materials or materials. Test strips can be adhered to a support or hard surface to improve the strength of the test strips.

被分析物通过信号发生系统而被检测到，如利用与本分析物发生特异性反应的一种或多种酶，利用如前述将特异结合物质固定在检测试纸上的方法，将一种或多种信号发生系统的组合物固定在检测试纸的被分析物检测区。产生信号的物质可在加样区，试剂区，或检测区，或整个检测试纸上，该物质可以充满检测试纸的一种或多种材料上。将含有信号物的溶液加到试纸的表面或将试纸的一种或多种材料浸没在含信号物的溶液中。使加入含信号物溶液的试纸干燥。The analyte is detected by a signal generating system, such as using one or more enzymes that specifically react with the analyte, using the method of immobilizing the specific binding substance on the detection test paper as described above, and combining one or more enzymes. The composition of the signal generating system is immobilized on the analyte detection area of the test strip. The signal-generating substance may be in the sample application area, the reagent area, or the detection area, or the entire test strip, and the substance may impregnate one or more materials of the test strip. The signal-containing solution is added to the surface of the test paper or one or more materials of the test paper are immersed in the signal-containing solution. The test paper to which the signal containing solution was added was allowed to dry.

检测试纸的各个区可以按以下方式排列：加样区，试剂区，检测区，控制区，确定样本是否掺假区，液体样本吸收区。控制区位于检测区之后。所有的区可以被安排在只用一种材料的一条试纸上。也可是不同区采用不同的材料。各个区可以直接和液体样本接触，或不同的区依据液体样本流动的方向排列，将各区的末端与另一区的前端相连并交叠。所用的材料可以是吸水性较好的材料如滤纸，玻纤或者硝酸纤维素膜等。检测试纸也可以采用其他形式。The various areas of the test strip can be arranged in the following ways: sample addition area, reagent area, detection area, control area, determination of whether the sample is adulterated or not, and liquid sample absorption area. The control area is located after the detection area. All zones can be arranged on a strip of test strips using only one material. It is also possible to use different materials for different zones. Each zone can be in direct contact with the liquid sample, or different zones can be arranged according to the direction of the liquid sample flow, and the end of each zone can be connected and overlapped with the front end of another zone. The material used can be a material with better water absorption such as filter paper, glass fiber or nitrocellulose membrane. Test strips can also take other forms.

一般常用的试剂条为硝酸纤维素膜试剂条，即检测区域包括硝酸纤维素膜，在硝酸纤维素膜上固定特异结合分子来显示检测的结果；还可以是醋酸纤维素膜或尼龙膜等等。例如如下一些专利描述的试剂条或含有试剂条的装置：US 4857453；US 5073484；US5119831；US 5185127；US 5275785；US 5416000；US 5504013；US 5602040；US 5622871；US5654162；US 5656503；US 5686315；US 5766961；US 5770460；US 5916815；US 5976895；US6248598；US 6140136；US 6187269；US 6187598；US 6228660；US 6235241；US 6306642；US6352862；US 6372515；US 6379620；和US 6403383。以上专利文献所公开的测试条以及带有测试条的类似装置都可以被运用到本实用新型的测试元件或者检测装置中进行被分析物质的检测，例如样本中被分析物质的检测。The commonly used reagent strips are nitrocellulose membrane reagent strips, that is, the detection area includes a nitrocellulose membrane, and specific binding molecules are immobilized on the nitrocellulose membrane to display the detection results; it can also be a cellulose acetate membrane or a nylon membrane, etc. . For example, the following patents describe reagent strips or devices containing reagent strips: US 4,857,453; US 5,073,484; US 5,119,831; US 5,185,127; US 5,275,785; US 5,766,961; US 5,770,460; US 5,916,815; US 5,976,895; US 6,248,598; US 6,140,136; The test strips disclosed in the above patent documents and similar devices with test strips can be applied to the test element or detection device of the present invention to detect the analyte, such as the detection of the analyte in the sample.

运用到本实用新型的检测试剂条可以是通常所说的横向侧流试剂条(Lateralflow test strip)，这些检测试剂条的具体结构和检测原理在现有技术中是本领域一般技术人员公知的技术。普通的检测试剂条，包括样本收集区域，标记区域，检测区域和吸水区域，样本收集区域包括样本接受垫，标记区域包括标记垫，吸水区域可以包括吸水垫，其中检测区域上包括能检测是否含有被分析物质的必要化学物质,例如免疫试剂或者酶化学试剂。一般常用的检测试剂条为硝酸纤维素膜试剂条，即检测区域包括硝酸纤维素膜，在硝酸纤维素膜上固定特异结合分子来显示检测的结果；还可以是醋酸纤维素膜或尼龙膜等等，当然，在检测区域的下游还可以包括检测结果控制区域，通常，控制区域和检测区域上以横线的形式出现，为检测线或者控制线。这样的检测试剂条是传统的试剂条，当然，也可是其他利用毛细作用进行检测的其它类型的试剂条。另外，一般检测试剂条上带有干化学试剂成分，例如固定的抗体或者其他试剂，当遇到液体后，液体随着毛细作用沿着试剂条流动，随着流动，让干的试剂成分溶解于液体，从而到下一个区域处理在该区的干试剂发生反应，从而进行必要的检测。液体流动主要通过毛细作用进行的。这些测试元件见如下文件的描述和记载：李福刚的《硝酸纤维素膜的再生处理及其吸附蛋白能力的研究》；马红艳，李强等的《胶体金诊断试剂盒中层析膜材料性能的分析》；王勇，王路海等的《一种新型胶体金免疫层析试纸条》。在这里都可以被运用到本实用新型的检测装置中，或者被设置在检测腔中与液体样本接触，或者用来检测进入检测腔中的液体样本中被分析物质是否存在或者存在的数量。The detection reagent strips applied to the present invention can be commonly referred to as lateral flow test strips (Lateralflow test strips), and the specific structures and detection principles of these detection reagent strips are well known to those of ordinary skill in the art . Common detection reagent strips include a sample collection area, a marking area, a detection area and a water absorption area. The sample collection area includes a sample receiving pad, and the labeling area includes a labeling pad. The necessary chemical substances for the analyte, such as immunological reagents or enzymatic chemical reagents. The commonly used detection reagent strips are nitrocellulose membrane reagent strips, that is, the detection area includes a nitrocellulose membrane, and specific binding molecules are immobilized on the nitrocellulose membrane to display the detection results; it can also be a cellulose acetate membrane or a nylon membrane, etc. Etc., of course, a detection result control area may also be included downstream of the detection area. Usually, the control area and the detection area appear in the form of horizontal lines, which are detection lines or control lines. Such detection reagent strips are traditional reagent strips, of course, other types of reagent strips that utilize capillary action for detection. In addition, the general detection reagent strip has dry chemical reagent components, such as immobilized antibodies or other reagents. When encountering liquid, the liquid flows along the reagent strip with capillary action, and with the flow, the dry reagent components are dissolved in the The liquid, thus proceeding to the next zone for processing, reacts with the dry reagents in that zone to perform the necessary detection. Liquid flow occurs primarily through capillary action. These test elements are described and recorded in the following documents: Li Fugang's "Regeneration of Nitrocellulose Membrane and Research on Its Ability to Adsorb Proteins"; Ma Hongyan, Li Qiang et al. "Analysis of the Properties of Chromatography Membrane Materials in Colloidal Gold Diagnostic Kits" ; Wang Yong, Wang Luhai et al. "A New Colloidal Gold Immunochromatographic Test Strip". All of them can be applied to the detection device of the present invention, or set in the detection chamber to contact the liquid sample, or used to detect the presence or quantity of the analyte in the liquid sample entering the detection chamber.

除了上述测试元件以试剂条的形式，其本身被用来与某一个较大的腔室，例如本申请中的第三腔43的液体接触来测试液体样本中是否含有被分析物质外，在一些优选的方式中，测试元件也可以被设置在一个集中的测试卡上，测试卡上具有很多凹槽，测试元件位于凹槽中，整个测试卡被设置在检测区域45内，由于第三腔43和检测区域45之间具有将二者连通的检测入口46，进入到第三腔43内的液体样本可以通过检测入口46进入到检测区域45内，从而被测试卡上的测试元件所检测。当然，除以上公开的载体外，另外的载体也可以被运用到本实用新型中作为承载测试条的载体。例如，在一些方式中，第三腔43或者其他的腔室可以先收集液体样本，然后用单独用测试条或带有测试条的卡片或者载体插入到第三腔43中进行检测。本领域的一般技术人员可以理解，根据本实用新型所记载的，这些测试条可以没有被设置在载体上，而是独立存在，本实用新型的检测区域45也是在一些情况下可以缺少的，测试条也是可以在一些情况下是可以缺少的。In addition to the above-mentioned test element in the form of a reagent strip, which itself is used to contact the liquid in a certain larger chamber, such as the third chamber 43 in this application, to test whether the liquid sample contains the analyte substance, in some In a preferred way, the test elements can also be arranged on a centralized test card, the test card has many grooves, the test elements are located in the grooves, and the whole test card is arranged in the detection area 45, because the third cavity 43 There is a detection inlet 46 connected to the detection area 45 , and the liquid sample entering the third cavity 43 can enter the detection area 45 through the detection inlet 46 and be detected by the test element on the test card. Of course, in addition to the carriers disclosed above, other carriers can also be used in the present invention as carriers for carrying test strips. For example, in some manners, the third chamber 43 or other chambers may first collect a liquid sample and then use a separate test strip or a card or carrier with a test strip to be inserted into the third chamber 43 for testing. Those skilled in the art can understand that, according to the description of the present invention, these test strips may not be arranged on the carrier, but exist independently. The detection area 45 of the present invention may also be missing in some cases. Bars can also be missing in some cases.

液体的流动flow of liquid

液体的流动，又可以称之为样本的流动或者液体样本的流动，在有些情况下，样本的转移也是通过流动来实现的，液体的流通通常是指从一个地方流动到另外一个地方，一般情况下，自然界的液体的流动大多数依靠重力的作用从高处流到低处，这里的流动也是依靠外力，即外在的重力情况下的流动，可以成为自然重力的流动。除了重力之外，液体的流动也可以克服重力，进行从低处流动到高处的运动。例如，液体的抽取、或者液体的压迫，或者液体受到压力，而从低处流动到高处，也或者由于压力的关系而克服液体自身的重力而进行的流动。The flow of liquid can also be called the flow of samples or the flow of liquid samples. In some cases, the transfer of samples is also achieved by flow. The flow of liquid usually refers to the flow from one place to another. Most of the flow of liquids in nature depends on the action of gravity to flow from high to low. The flow here also depends on external force, that is, the flow under external gravity can become the flow of natural gravity. In addition to gravity, the flow of liquids can also overcome gravity and move from low to high. For example, the extraction of the liquid, or the compression of the liquid, or the flow of the liquid from a low place to a high place under pressure, or the flow of the liquid against the gravity of the liquid itself due to the relationship of the pressure.

例如，图27-29中，第三腔位于第一腔和第四腔上，第四腔位于第三腔下，当有液体进入第三腔的时候，液体依靠自身的重力作用，可以从第三腔自然的依靠重力流动到第一腔和第四腔中，也可以从上游自然地流动到下游位置，当装置整体摇晃时，液体也有可能因为重力方向的改变而发生流向的变化。For example, in Figures 27-29, the third cavity is located on the first cavity and the fourth cavity, and the fourth cavity is located under the third cavity. When a liquid enters the third cavity, the liquid relies on its own gravity to move from the first cavity to the fourth cavity. The three cavities naturally flow into the first cavity and the fourth cavity by gravity, and can also flow naturally from the upstream to the downstream position. When the device is shaken as a whole, the flow direction of the liquid may also change due to the change of the direction of gravity.

被分析物质analyte

能够用本实用新型中涉及的被分析物的例子包括一些小分子物质，这些小分子包括毒品(如滥用药物)。“滥用药物”(DOA)是指非医学目的地使用药品(通常起麻痹神经的作用)。滥用这些药物会导致身体和精神受到损害，产生依赖性、上瘾并且/或者死亡。药物滥用的例子包括可卡因；安非他明AMP(例如，黑美人、白色安非他命药片、右旋安非他命、右旋苯异丙胺药片、Beans)；甲基苯丙胺MET(crank、甲安菲他明、crystal，speed)；巴比妥酸盐BAR(如Valium，Roche Pharmaceuticals，Nutley，New Jersey)；镇静剂(即睡觉辅助药品)；麦角酸酰二乙胺(LSD)；抑制剂(downers，goofballs，barbs，blue devils，yellowjackets，安眠酮)；三环类抗抗抑郁剂(TCA，即丙咪嗪、阿密曲替林和多虑平)；二甲二氧基甲基苯胺MDMA；苯环己哌啶(PCP)；四氢大麻醇(THC、pot，dope，hash，weed，等。)；鸦片制剂(即吗啡MOP或者、鸦片、可卡因COC；、海洛因，羟二氢可待因酮)；抗焦虑药与镇静催眠药，抗焦虑药是一类主要用于减轻焦虑、紧张、恐惧，稳定情绪，兼有催眠镇静作用的药物，包括苯二氮卓类BZO(benzodiazepines)、非典型BZ类、融合二氮NB23C类、苯氮卓类、BZ受体的配体类、开环BZ类、二苯甲烷衍生物、哌嗪羧酸盐类、哌啶羧酸盐类、奎唑啉酮类、噻嗪及噻唑衍生物、其他杂环类、咪唑型镇静/止痛药(如羟二氢可待因酮OXY，美沙酮MTD)、丙二醇衍生物—氨甲酸酯类、脂肪族化合物、蒽类衍生物等。使用本实用新型的检测装置也可以用于检测属于医学用途但又容易服药过量的检测，如三环类抗抑郁药(丙米嗪或类似物)和乙酰氨基酚等。这些药品被人体吸收后会代谢成小分子物质，这些小分子物质存在于血液、尿液、唾液、汗水等体液中或部分体液存在上述小分子物质。Examples of analytes that can be used in the present invention include small molecules, including drugs (eg, drugs of abuse). "Substance of Abuse" (DOA) refers to the use of drugs (usually to paralyze nerves) for non-medical purposes. Abuse of these drugs can lead to physical and mental damage, dependence, addiction and/or death. Examples of drugs of abuse include cocaine; amphetamines AMP (eg, black beauty, white amphetamine tablets, dextroamphetamine, dextroamphetamine tablets, Beans); methamphetamine MET (crank, methamphetamine, crystal , speed); barbiturates BAR (eg, Valium, Roche Pharmaceuticals, Nutley, New Jersey); sedatives (ie, sleep aids); lysergic acid diethylamide (LSD); inhibitors (downers, goofballs, barbs, blue devils, yellowjackets, mepranolone); tricyclic antidepressants (TCA, i.e. imipramine, amitriptyline, and doxepin); MDMA; phencyclidine (PCP); Tetrahydrocannabinol (THC, pot, dope, hash, weed, etc.); Opiates (i.e. morphine MOP or, opium, cocaine COC; heroin, oxycodone); anxiolytics Drugs and sedative-hypnotics, anti-anxiety drugs are a class of drugs mainly used to reduce anxiety, tension, fear, stabilize emotions, and have both hypnotic and sedative effects, including benzodiazepines BZO (benzodiazepines), atypical BZ, fusion Diazepine NB23Cs, benzoazepines, ligands of BZ receptors, ring-opening BZs, diphenylmethane derivatives, piperazine carboxylates, piperidine carboxylates, quinazolinones, thiazides Oxine and thiazole derivatives, other heterocycles, imidazole-type sedative/analgesics (such as oxydihydrocodeinone OXY, methadone MTD), propylene glycol derivatives - carbamates, aliphatic compounds, anthracene derivatives, etc. . The detection device of the utility model can also be used for detection of overdose which belongs to medical purposes but is easy to take, such as tricyclic antidepressants (imipramine or the like) and acetaminophen. These drugs are metabolized into small molecular substances after being absorbed by the human body. These small molecular substances exist in blood, urine, saliva, sweat and other body fluids or in some body fluids.

例如，用本实用新型检测的被分析物包括但不限于，肌氨酸酐、胆红素、亚硝酸盐、蛋白(非特异性)，激素(例如，人绒毛促进性激素、黄体酮激素、卵泡刺激素等)，血液，白血球，糖，重金属或毒素，细菌物质(如针对特异性细菌的蛋白或糖类物质，如比如大肠杆菌0157：H7、葡萄球菌、沙门氏菌、梭菌属、弯曲菌属、L.monocytogenes、弧菌属、或仙人掌杆菌)和尿样中与生理特征相关的物质，如pH和比重。其他任何临床尿化学分析都可利用侧向横流检测形式配合本实用新型装置进行检测。For example, analytes detected by the present invention include, but are not limited to, creatinine, bilirubin, nitrite, proteins (non-specific), hormones (eg, human villi-stimulating hormone, progesterone hormone, follicle stimulating hormone) etc.), blood, leukocytes, sugars, heavy metals or toxins, bacterial substances (such as proteins or carbohydrate substances against specific bacteria, such as e.g. Escherichia coli 0157:H7, Staphylococcus, Salmonella, Clostridium, Campylobacter, L .monocytogenes, Vibrio spp., or Cactobacillus spp.) and urine samples for substances related to physiological characteristics, such as pH and specific gravity. Any other clinical urine chemical analysis can be detected in the form of lateral cross-flow detection in conjunction with the device of the present invention.

连通和/或隔断connect and/or disconnect

在本实用新型中，连通是指一种流体连通的状态，也即，在这个结构中，流体能够从一个区域到另一个区域，或者在能够从结构的一部分到另一部分，或者能够从结构的第一个腔体到另一个腔体，这里的“到”是通过流体本身的流动性来实现的，连通具体是指流体连通，即气体连通或者液体连通。气体连通或者液体连通是指液体或者气体能够从一个地方流动到另一个地方，流动的过程中可能经过一些物理的结构起到引导作用。所谓经过物理的结构一般是指液体经过这些物理的结构的表面，或者这些结构的内部的空间而被动或者主动流到另外一个地方，被动一般是收到外力而引起的流动，例如毛细作用下的流动。这里的流动也可以是液体或者气体因为自身作用(重力或者压力)，也可以是被动的流动。这里的连通并不表示一定需要液体或者气体存在，仅仅在一些情况下表明两个物体之间的连接关系或者状态，如果有液体存在，可以从一个物体流动到另一个物体上。这里是指两个物体连接的状态，相反，如果两个物体之间没有液体连通或者气体连通状态，如果有液体在一个物体中或者上，液体不能流动到另外一个物体中或者上，这样的状态为非连通，非液体或者气体连通的状态。在本实用新型中，有时候也直接将这种气体连通或者液体连通的状态，称之为流体连通或者简称为连通，这种连通并不需要结构内实际存在流体(例如液体或者气体)，只是结构能够处于这样一种状态的表示。相对应地，本实用新型中的隔断是指与连通(流体连通)相反的状态，即不连通，也就是说，在隔断状态下，流体无法在流动性的作用下实现上述的从一个区域到另一个区域，或者在能够从结构的一部分到另一部分，或者能够从结构的第一个腔体到另一个腔体，同样，隔断也不需要结构中实际存在液体，可以只是结构的一种状态。In the present invention, communication refers to a state of fluid communication, that is, in this structure, the fluid can pass from one area to another area, or from one part of the structure to another part, or from the structure. From the first cavity to the other cavity, the "to" here is realized by the fluidity of the fluid itself, and the communication specifically refers to fluid communication, that is, gas communication or liquid communication. Gas communication or liquid communication means that liquid or gas can flow from one place to another, and may pass through some physical structures to guide the flow. The so-called physical structure generally refers to the liquid passing through the surface of these physical structures, or the internal space of these structures and passively or actively flowing to another place. Passive is generally the flow caused by external force, such as capillary action. flow. The flow here can also be a liquid or gas due to its own action (gravity or pressure), or it can be a passive flow. The connection here does not necessarily mean the existence of liquid or gas, but only indicates the connection relationship or state between two objects in some cases. If there is liquid, it can flow from one object to another. This refers to the state in which two objects are connected. On the contrary, if there is no liquid communication or gas communication between the two objects, if there is liquid in or on one object, the liquid cannot flow into or on the other object, such a state It is a state of non-communication, non-liquid or gas communication. In the present invention, sometimes the state of gas communication or liquid communication is also directly referred to as fluid communication or simply communication. This kind of communication does not require the actual existence of fluid (such as liquid or gas) in the structure, but only A representation that a structure can be in such a state. Correspondingly, the partition in the present utility model refers to the state opposite to communication (fluid communication), namely non-communication, that is to say, in the partition state, the fluid cannot realize the above-mentioned transition from one area to the other under the action of fluidity. Another area, or can go from one part of the structure to another, or from the first cavity of the structure to another cavity, likewise, the partition does not require the actual presence of liquid in the structure, it can just be a state of the structure .

检测装置或收集装置detection device or collection device

检测装置是指用于检测样本中是否含有被分析物质的装置。收集装置是指进行液体样本的收集和储存的装置。检测装置可以包括收集装置，收集装置也可以包括检测装置，或者收集装置与检测装置分隔开，在检测的时候，对收集装置和检测装置进行组合，从而完成检测。也可以是，收集装置和检测装置为一体结构的装置，一旦收集液体样本后，就可以马上进行检测，获得测试结果，同时进行检测样本与收集样本的分隔，从而可以进行二次检测(如果需要)。这里的检测装置或者检测腔体的意思可以互换，收集装置与收集腔体也可以互换，只是起到的作用不同而进行功能的互换。比如，本实用新型说到收集装置的时候，可以不包括检测腔，但是收集装置可以包括有测试元件或者含有测试元件的载体，含有测试元件的收集装置也可以称之为检测装置。当然，收集装置可以包含用来设置测试元件的空间，但是并不一定必须含有测试元件，测试元件可以在后续任何合适的时候和收集装置进行组合而成为检测装置。例如，收集装置可以包括用来容纳测试元件的空间，例如含有检测区域45，或者在收集装置的收集液体的腔中具有合适的位置来设置测试元件或者含有测试元件的载体。A detection device refers to a device used to detect whether a sample contains an analyte. A collection device refers to a device that performs the collection and storage of liquid samples. The detection device may include a collection device, and the collection device may also include a detection device, or the collection device may be separated from the detection device. During detection, the collection device and the detection device are combined to complete the detection. It can also be a device with an integrated structure of the collection device and the detection device. Once the liquid sample is collected, the detection can be carried out immediately to obtain the test result, and the detection sample and the collected sample can be separated at the same time, so that the secondary detection can be carried out (if necessary. ). The meanings of the detection device or the detection cavity here can be interchanged, and the collection device and the collection cavity can also be interchanged, but the functions are interchanged due to different roles. For example, when the present invention refers to a collection device, it may not include a detection chamber, but the collection device may include a test element or a carrier containing the test element, and the collection device containing the test element may also be called a detection device. Of course, the collection device may include a space for arranging the test element, but it does not necessarily have to contain the test element, and the test element can be combined with the collection device at any subsequent suitable time to become the detection device. For example, the collection device may include a space for receiving the test element, eg, containing the detection area 45, or have suitable locations in the liquid-collecting cavity of the collection device to place the test element or a carrier containing the test element.

用于收集液体样本的第一腔first chamber for collecting liquid samples

在本实用新型的一些具体实施方式中，如图27-29所示的具体方式中，本实用新型提供一种用于收集液体样本的收集装置，或者用于检测液体样本的检测装置，当然，该检测装置也具有收集的功能或者也包括收集装置，这个收集装置或者检测装置包含第一腔41，第一腔41可以作为直接收集的腔室来使用，也可以通过其他的腔室例如第三腔43来实现样本的收集。In some specific embodiments of the present invention, as shown in Figures 27-29, the present invention provides a collection device for collecting liquid samples, or a detection device for detecting liquid samples, of course, The detection device also has a collection function or also includes a collection device. This collection device or detection device includes a first chamber 41. The first chamber 41 can be used as a direct collection chamber, or through other chambers such as a third chamber. Cavity 43 to achieve sample collection.

当第一腔41作为直接收集的腔体时，其本身可以具有一个直接连通外部的开口，可以通过该开口向第一腔41内注入或装入样本，例如图26所示的结构，此时第一腔41可以从外部直接收集样本。当第一腔41通过其他的腔室来实现样本的收集时，如图27-29所示，其通过一个第一通道47与第三腔43直接连通，并且，第一腔41位于第三腔43的下方，第三腔43具有一个向上的收集口49，通过该收集口49，液体样本可以进入到第三腔43内并在重力作用下自然下落或者往下流，自然下落并进入第一通道的那部分液体样本可以直接落入第一腔41内，在自然下落过程中必然有一部分液体样本是无法直接落入第一通道47的，那么这部分液体样本可以在第三腔43的底部集聚，当液面高度超过从第一通道47高出第三腔43底部的高度时，这部分液体便会通过第一通道47流入到第一腔41内。When the first cavity 41 is used as a cavity for direct collection, it may have an opening directly communicating with the outside, and samples can be injected or loaded into the first cavity 41 through the opening, such as the structure shown in FIG. 26 , at this time The first chamber 41 can directly collect samples from the outside. When the first chamber 41 collects samples through other chambers, as shown in FIGS. 27-29 , it directly communicates with the third chamber 43 through a first channel 47 , and the first chamber 41 is located in the third chamber Below 43, the third cavity 43 has an upward collection port 49, through which the liquid sample can enter the third cavity 43 and fall naturally or flow downward under the action of gravity, fall naturally and enter the first channel That part of the liquid sample can directly fall into the first cavity 41 , and there must be a part of the liquid sample that cannot directly fall into the first channel 47 during the natural fall process, so this part of the liquid sample can accumulate at the bottom of the third cavity 43 . , when the liquid level exceeds the height from the first channel 47 above the bottom of the third cavity 43 , this part of the liquid will flow into the first cavity 41 through the first channel 47 .

在一些优选的方式中，例如，从图中可以看出的，在第一通道47的侧壁上可以开设一个收集槽50，这个收集槽50可以与第三腔43的底部齐平或者略高于第三腔的底部，在自然下落过程中并未进入第一通道47的那部分液体样本会最终汇集到第三腔43的底部，由于收集槽与第三腔43的底部高度比较接近，在第三腔43底部的液体样本很大可能会通过收集槽50进入到第一通道47内从而顺着第一通道47流入到第一腔41内。需要说明的是，由于我们并不需要第三腔43内所有的样本都流入到第一腔41内，只需要其中的一部分，因此，只要收集到的液体的量足够，必然会有一部分样本会进入到第一通道47内，并且，由于实际使用中，整个腔体可能会处于一个非静止的状态，例如被手持，那么所采集到的样本也会由于摇晃而更大可能地进入到收集槽50内。In some preferred ways, for example, as can be seen from the figure, a collection groove 50 may be opened on the side wall of the first channel 47 , and this collection groove 50 may be flush with the bottom of the third cavity 43 or slightly higher At the bottom of the third cavity, the part of the liquid sample that did not enter the first channel 47 during the natural fall will eventually collect at the bottom of the third cavity 43. Since the height of the collection tank is relatively close to the bottom of the third cavity 43, at the bottom of the third cavity 43 The liquid sample at the bottom of the third cavity 43 is likely to enter the first channel 47 through the collection groove 50 and flow into the first cavity 41 along the first channel 47 . It should be noted that, since we do not need all the samples in the third chamber 43 to flow into the first chamber 41, only a part of them is needed. Therefore, as long as the amount of collected liquid is sufficient, a part of the samples will inevitably flow into the first chamber 41. Enter into the first channel 47, and, due to actual use, the entire cavity may be in a non-stationary state, such as being held by hand, then the collected sample will also be more likely to enter the collection tank due to shaking within 50.

在一些优选的方式中，第一腔41内的液体样本可以直接用于检测。在一些优选的方式中，第三腔43内的液体样本可以直接用于检测。在一些优选的方式中，第一腔41内的液体样本可以被转移到其他腔体内，例如第二腔42。In some preferred manners, the liquid sample in the first chamber 41 can be directly used for detection. In some preferred manners, the liquid sample in the third chamber 43 can be directly used for detection. In some preferred manners, the liquid sample in the first chamber 41 can be transferred to other chambers, such as the second chamber 42 .

在一些优选的方式中，第一腔41的体积是可变的，例如图27-29所示的过程中，第一腔41实际上是移液通道51中的一段空间，这一段空间是被第一移液元件52和第二移液元件53所隔离而形成的，当第一移液元件52或者第二移液元件53或者两个移液元件在移液通道51内移动时，第一腔41的体积就会发生变化。在一些优选的方式中，第一腔41的体积可以被压缩，此时其中存储的液体样本会被挤出，至其他腔室中或者用于其他用途。在一些优选的方式中，第一腔41的体积也可以被扩大，在这种情况下，第一腔41内会产生向内的吸引力，使其更快收集到更多的液体样本，或者，在一些优选的方式中，第一腔41的体积会随着所收集样本的增加而扩大。In some preferred manners, the volume of the first cavity 41 is variable. For example, in the process shown in FIGS. 27-29 , the first cavity 41 is actually a section of space in the pipetting channel 51 , and this section of space is The first pipetting element 52 and the second pipetting element 53 are isolated and formed. When the first pipetting element 52 or the second pipetting element 53 or the two pipetting elements move in the pipetting channel 51, the first pipetting element The volume of cavity 41 changes. In some preferred manners, the volume of the first chamber 41 can be compressed, at which time the liquid sample stored therein is squeezed out into other chambers or used for other purposes. In some preferred manners, the volume of the first cavity 41 can also be enlarged, in which case, an inward attraction force will be generated in the first cavity 41 so that more liquid samples can be collected faster, or , in some preferred manners, the volume of the first cavity 41 will expand with the increase of the collected samples.

自密封self-sealing

所述的自密封是指，在除了腔体自身或者腔体内所容纳的物体(包括液体、气体以及其他物质)可能对腔体的内壁或者外壁所产生的压力以外，没有其他任何作用力作用在腔体上的时候，腔体可以处于密封状态，腔体内部与外界或者其他腔体之间处于流体隔离的状态，不能够允许流体交换(包括液体、气体等)。在有些情况下，所述的自密封是指，除了上述腔体自身或者腔体内所容纳的物体(包括液体、气体以及其他物质)可能对腔体的内壁或者外壁所产生的压力以外，即使对腔体的内壁或者外壁施加一定的外力，只要这个外力不足够大或者没有达到一定的值，腔体仍然处于上述密封的状态。在有些情况下，腔体上可能存在开口或者被刺破的孔，但是由于腔体所采用的材质或者具有一定壁厚的关系，这个开口或者被刺破的孔，也可以满足上述在内力或者不足够大的外力作用下，不会打开的条件，并且，当施加了外力或者外力足够大的时候，腔体不需要其他部件的介入即能够与外界或者其他腔体实现液体连通(可以是通过所述的开口或者被刺破的孔)，而在这个外力撤去之后，又能够恢复到原来的流体隔离状态时，我们将这个腔体称之为可以自密封的腔体。The self-sealing refers to that there is no other force acting on the inner wall or outer wall of the cavity except the pressure generated by the cavity itself or the objects (including liquid, gas and other substances) contained in the cavity to the inner wall or outer wall of the cavity. When on the cavity, the cavity can be in a sealed state, and the interior of the cavity is in a state of fluid isolation from the outside world or other cavities, and fluid exchange (including liquid, gas, etc.) cannot be allowed. In some cases, the self-sealing refers to that, in addition to the pressure generated by the cavity itself or the objects (including liquid, gas and other substances) contained in the cavity on the inner or outer wall of the cavity, even if the The inner wall or outer wall of the cavity exerts a certain external force. As long as the external force is not large enough or does not reach a certain value, the cavity is still in the above-mentioned sealed state. In some cases, there may be an opening or a punctured hole in the cavity, but due to the material used in the cavity or a certain wall thickness, the opening or the punctured hole can also satisfy the above-mentioned internal force or If the external force is not large enough, it will not open, and when the external force is applied or the external force is large enough, the cavity can achieve liquid communication with the outside world or other cavities without the intervention of other components (which can be through The opening or the punctured hole), and after the external force is removed, when the original fluid isolation state can be restored, we call this cavity a self-sealing cavity.

用于收集液体样本的第三腔Third chamber for collecting liquid samples

在本实用新型的一些具体实施方式中，如图20-23，本实用新型提供一种用于收集液体样本的收集装置，或者用于检测液体样本的检测装置，当然，该检测装置也具有收集的功能或者也包括收集装置，这个收集装置或者检测装置包含第三腔43，第三腔43可以作为直接收集的腔室来使用，也可以作为检测的腔体来使用，或者该第三腔43还可以作为一个临时存储的腔体，使进入其中的液体样本通过第三腔43进入到其他的腔体内，其他的腔体可以是收集腔体，也可以是检测腔体。In some specific embodiments of the present invention, as shown in Figures 20-23, the present invention provides a collection device for collecting liquid samples, or a detection device for detecting liquid samples. Of course, the detection device also has a collection device for collecting liquid samples. The function or also includes a collection device, this collection device or detection device contains a third cavity 43, the third cavity 43 can be used as a direct collection chamber, or can be used as a detection cavity, or the third cavity 43 It can also be used as a temporary storage cavity, so that the liquid sample entering into it can enter into other cavities through the third cavity 43 , and the other cavities can be collection cavities or detection cavities.

例如，在图27-29所示的具体方式中，第三腔43作为第一腔41收集液体样本的过渡腔体，通过如前所述的一些方式，第一腔41可以同时收集到进入第三腔43内的液体样本。当然第三腔43也可以通过其他的腔室来收集样本。For example, in the specific manner shown in FIGS. 27-29 , the third chamber 43 is used as a transition chamber for the first chamber 41 to collect the liquid sample. By some methods as described above, the first chamber 41 can simultaneously collect the liquid sample into the first chamber 41 and enter the first chamber 41 . Liquid sample in three chambers 43 . Of course, the third chamber 43 can also collect samples through other chambers.

当第三腔43作为一个过渡腔体时，如图21所示，其底部可能会具有与第一腔41液体连通的第一通道47，以及与第四腔44液体连通的第二通道48，在这种情况下，只要第一通道47和第二通道48没有被封闭，则第一腔41和第四腔44就可能够与第三腔43基本上是同步完成样本的收集。When the third cavity 43 is used as a transition cavity, as shown in FIG. 21 , the bottom of the third cavity 43 may have a first channel 47 in liquid communication with the first cavity 41 and a second channel 48 in liquid communication with the fourth cavity 44 . In this case, as long as the first channel 47 and the second channel 48 are not blocked, the first chamber 41 and the fourth chamber 44 may be able to complete the collection of the sample substantially simultaneously with the third chamber 43 .

在一些优选的方式中，第三腔43还可以通过一个检测入口46和检测区域45实现液体连通，检测入口46可以被调整或者设置为连通或者隔断，这样就可以根据需要将第三腔43内的液体引入到检测区域45内，检测区域45内可以设置测试元件，也可以不设置测试元件。当检测区域内设置测试元件时，为了便于观察，检测区域可以采用透明材料制成。In some preferred manners, the third cavity 43 can also be in liquid communication with the detection area 45 through a detection inlet 46, and the detection inlet 46 can be adjusted or set to be connected or disconnected, so that the third cavity 43 can be connected according to needs. The liquid is introduced into the detection area 45, and a test element may or may not be provided in the detection area 45. When testing elements are arranged in the detection area, the detection area can be made of transparent material for easy observation.

在一些优选的方式中，在第一通道47的侧壁上可以开设一个收集槽50，这个收集槽50可以与第三腔43的底部齐平或者略高于第三腔的底部，在自然下落过程中并未进入第一通道47的那部分液体样本会最终汇集到第三腔43的底部，由于收集槽与第三腔43的底部高度比较接近，在第三腔43底部的液体样本很大可能会通过收集槽50进入到第一通道47内从而顺着第一通道47流入到第一腔41内。需要说明的是，由于我们并不需要第三腔43内所有的样本都流入到第一腔41内，只需要其中的一部分，因此，只要收集到的液体的量足够，必然会有一部分样本会进入到第一通道47内，并且，由于实际使用中，整个腔体可能会处于一个非静止的状态，例如被手持，那么所采集到的样本也会由于摇晃而更大可能地进入到收集槽50内。In some preferred manners, a collection groove 50 may be opened on the side wall of the first channel 47 , and the collection groove 50 may be flush with the bottom of the third cavity 43 or slightly higher than the bottom of the third cavity, and it can be naturally The part of the liquid sample that did not enter the first channel 47 during the process will eventually be collected to the bottom of the third cavity 43. Since the height of the collection tank is relatively close to the bottom of the third cavity 43, the liquid sample at the bottom of the third cavity 43 is very large. It may enter the first channel 47 through the collecting groove 50 and flow into the first cavity 41 along the first channel 47 . It should be noted that, since we do not need all the samples in the third chamber 43 to flow into the first chamber 41, only a part of them is needed. Therefore, as long as the amount of collected liquid is sufficient, a part of the samples will inevitably flow into the first chamber 41. Enter into the first channel 47, and, due to actual use, the entire cavity may be in a non-stationary state, such as being held by hand, then the collected sample will also be more likely to enter the collection tank due to shaking within 50.

在一些优选的方式中，第一腔41和第三腔43可以在初始收集的时候处于液体隔离的状态，即，由第三腔43所收集到的液体样本不会自动进入或者不能够在样本自重的作用力下直接进入到第一腔41内，例如第一腔41和第三腔43之间的连通关系被某个元件隔断，当对第三腔43内的液体样本施加一定的作用力之后，可以冲破这个元件的隔断，从而使样本从第三腔43内进入第一腔41内。也就是说，在这种情况下，第一腔41不一定要作为一个初始收集样本的腔体，其可以作为一个通道，这个通道为样本从第三腔43进入到第二腔42提供了一条路径，由于这个路径的存在，样本可以直接进入到第二腔42内部而不会污染第二腔42的外壁。In some preferred manners, the first chamber 41 and the third chamber 43 may be in a state of liquid isolation at the time of initial collection, that is, the liquid sample collected by the third chamber 43 will not automatically enter or cannot be in the sample It directly enters the first cavity 41 under the force of its own weight. For example, the communication relationship between the first cavity 41 and the third cavity 43 is blocked by a certain element. When a certain force is applied to the liquid sample in the third cavity 43 Afterwards, the partition of this element can be broken, so that the sample enters the first cavity 41 from the third cavity 43 . That is to say, in this case, the first cavity 41 does not have to be used as a cavity for initially collecting samples, it can be used as a channel, which provides a path for the samples to enter from the third cavity 43 to the second cavity 42 Due to the existence of this path, the sample can directly enter the inside of the second cavity 42 without contaminating the outer wall of the second cavity 42 .

在一些优选的方式中，第三腔43可以被盖体密封。在一些优选的方式中，盖体可以直接和第三腔43连接从而密封第三腔。在一些优选的方式中，盖体可以直接密封包括检测区域在内的第三腔。在一些优选的方式中，盖体可以仅用于密封第三腔的收集口。在一些优选的方式中，盖体可以通过密封连接件与盖体连接。例如图24-25所示，对于收集口49和测试元件入口65的密封可以采用密封连接盖66，密封连接盖66包括用于盖住样本收集入口第一盖67和用于盖住测试元件入口65的第二盖68，通过第一盖67和第二盖68，密封连接盖66可以同时将收集口49和测试元件入口65盖住，密封连接盖66可以再连接盖体，或者，密封连接件本身就是密封状态的，如图所示，第一盖67和第二盖68卡接配合在第三腔和检测区域的开口部。除了图中所示的方式之外，还可以用薄膜进行热塑封，只要保证在检测的时候，该薄膜密封不透气或者不漏液就可以了，当完成检测后，让第二腔与装置主体分离后，装置主体(包括检测区域)可以作丢弃处理，而不必对整个检测装置进行储藏和运输。In some preferred manners, the third cavity 43 may be sealed by the cover. In some preferred manners, the cover body can be directly connected to the third cavity 43 to seal the third cavity. In some preferred manners, the cover body can directly seal the third cavity including the detection area. In some preferred manners, the cover may only be used to seal the collection port of the third cavity. In some preferred manners, the cover body can be connected to the cover body through a sealing connector. For example, as shown in FIGS. 24-25 , a sealing connection cover 66 can be used to seal the collection port 49 and the test element inlet 65. The sealing connection cover 66 includes a first cover 67 for covering the sample collection inlet and a first cover 67 for covering the test element inlet. The second cover 68 of 65, through the first cover 67 and the second cover 68, the sealing connection cover 66 can cover the collection port 49 and the test element inlet 65 at the same time, the sealing connection cover 66 can be reconnected to the cover body, or, the sealing connection The component itself is in a sealed state. As shown in the figure, the first cover 67 and the second cover 68 are snap-fitted to the opening of the third cavity and the detection area. In addition to the method shown in the figure, the film can also be used for thermoplastic sealing, as long as it is ensured that the film is air-tight or liquid-tight during the test. After the test is completed, let the second cavity and the device body be sealed. After separation, the main body of the device (including the detection area) can be disposed of without having to store and transport the entire detection device.

在一些优选的方式中，先向第三腔43内装入样本，第一腔41内并没有被装入样本。在一些优选的方式中，第三腔43内的样本可以在一定外力的作用下进入第一腔41内。例如，如图37所示，在一些优选的方式中，第一腔41可以设置一个穿过第三腔43的第三通道82，在初始收集时，这个第三通道82内不会被装入样本。在一些优选的方式中，第二腔42以及第二腔的装配结构可以装配到第三通道上，同样的用连通器58可以连通第一腔和第二腔42。在一些优选的方式中，可以将第三腔43内的样本在压力作用下从第一腔41直接压入到第三通道82内。在一些优选的方式中，第二腔42可以直接装配到第三通道82上。在一些优选的方式中，第三通道82和第三腔43具有共用的开口，但是装入样本时，是要稍加注意，便不会让样本进入到第三通道43内。在一些优选的方式中，初始收集样本时，为了以防万一，第三通道43可以被封闭，例如用塞子塞住，或者用薄膜封住。In some preferred manners, the sample is loaded into the third cavity 43 first, and the first cavity 41 is not loaded with the sample. In some preferred manners, the sample in the third cavity 43 can enter the first cavity 41 under the action of a certain external force. For example, as shown in FIG. 37 , in some preferred manners, the first cavity 41 may be provided with a third channel 82 passing through the third cavity 43 . During the initial collection, the third channel 82 will not be loaded into the first cavity 41 . sample. In some preferred manners, the second cavity 42 and the assembly structure of the second cavity can be assembled to the third channel, and the first cavity and the second cavity 42 can be communicated with the same communicating device 58 . In some preferred manners, the sample in the third chamber 43 can be directly pressed into the third channel 82 from the first chamber 41 under the action of pressure. In some preferred modes, the second cavity 42 may fit directly onto the third channel 82 . In some preferred manners, the third channel 82 and the third cavity 43 have a common opening, but when loading the sample, care should be taken to prevent the sample from entering the third channel 43 . In some preferred manners, when the sample is initially collected, the third channel 43 may be closed, for example, plugged with a stopper, or sealed with a film, just in case.

在一些优选的方式中，第三腔的底部设置一些能够连通第一腔的开孔，这些开孔能够在一定的条件下被打开，这些开孔仅仅连通第一腔和第三腔，而不与其他腔体或者外部连通。在一些优选的方式中，这些开孔设置在第三腔的底部。在一些优选的方式中，这些开孔设置在第一腔和第三腔共用的壁面上。在一些优选的方式中，这些开孔是压力孔83连通，当第三腔43内受到足够的压力时，压力孔83便会打开，让第一腔和第三腔能够实现流体连通，此时样本能够直接从第三腔进入到第一腔，当压力撤除时，压力孔83又能恢复闭合。在一些优选的方式中，压力孔可以采用如前所述的自封闭的开孔，例如类似“尖叫瓶”的开口。在一些优选的方式中，压力孔在闭合状态下，能够承受来第三腔在装满状态下的液体压力，也就是说，仅仅是向第三腔内装入样本，这些样本的自重不足以打开压力孔。在一些优选的方式中，在样本达到一定的收集量时，能够打开压力孔。在一些优选的方式中，压力孔所能承受的压力可以根据实际需要配置。在一个具体实施方式中，第一腔41的断面比第三通道82的断面宽，这样才能够使得第三通道82和第一腔41之间具有一段距离，压力孔83设置在这段距离上。在一些优选的方式中，对第三腔43内的压力可以来自于盖体，例如盖体上设有活塞向下推动或者挤压上液面，或者盖体盖入时可以产生压力，作用于上液面。In some preferred manners, the bottom of the third cavity is provided with some openings that can communicate with the first cavity, these openings can be opened under certain conditions, and these openings only communicate with the first cavity and the third cavity, not communicate with other cavities or the outside. In some preferred manners, the openings are provided at the bottom of the third cavity. In some preferred manners, the openings are provided on the common wall surface of the first cavity and the third cavity. In some preferred ways, these openings are connected to the pressure holes 83. When the third cavity 43 receives sufficient pressure, the pressure holes 83 will open, so that the first cavity and the third cavity can be in fluid communication. At this time The sample can directly enter the first chamber from the third chamber, and when the pressure is removed, the pressure hole 83 can be closed again. In some preferred manners, the pressure hole can be a self-closing opening as described above, such as an opening similar to a "screaming bottle". In some preferred manners, in the closed state, the pressure hole can withstand the liquid pressure from the third cavity in the full state, that is to say, only the samples are loaded into the third cavity, and the self-weight of these samples is not enough to open pressure hole. In some preferred manners, the pressure port can be opened when the sample reaches a certain collection volume. In some preferred manners, the pressure that the pressure hole can bear can be configured according to actual needs. In a specific embodiment, the section of the first cavity 41 is wider than the section of the third channel 82, so that there is a distance between the third channel 82 and the first cavity 41, and the pressure hole 83 is arranged on this distance . In some preferred manners, the pressure in the third cavity 43 can come from the cover body, for example, a piston is provided on the cover body to push down or squeeze the upper liquid surface, or the cover body can generate pressure when the cover body is put in, acting on the on the liquid level.

检测入口Detection entrance

检测入口46是收集腔和检测区域之间的连通口，但是，不需要将检测区域和收集腔时刻连通，收集腔可以和检测区域分隔开，并根据需要连通，在这种情况下，可以在检测入口46设置检测入口隔断件54，通过检测入口隔断件54来实现检测入口46可以被调整或者设置为连通或者隔断的功能，这样就可以根据需要将第三腔43内的液体引入到检测区域45内。The detection inlet 46 is a communication port between the collection chamber and the detection area, but it is not necessary to connect the detection area and the collection chamber at all times. The collection chamber can be separated from the detection area and communicated as needed. In this case, it can be A detection inlet partition 54 is provided at the detection inlet 46, and the detection inlet 46 can be adjusted or set to be connected or blocked through the detection inlet partition 54, so that the liquid in the third cavity 43 can be introduced to the detection according to the needs. within area 45.

例如，如图27所示的方式中，检测入口隔断件54具有一定的硬度和厚度，其上设有切口，切口的切面之间是过盈配合的，那么在没有压力或者压力不足的情况下，整个切口是处于闭合的状态，可以隔断液体流通，但是当切口的一侧受到压力的情况下，切口就会顺着压力的方向敞开，进行自然泄压，也就是说，当切口的一侧有一定量的样本，或者对样本施加一定的压力，就可以冲开切口，使收集腔和检测区域45液体连通，当压力撤除之后，切口又可以恢复闭合的状态。For example, in the manner shown in FIG. 27 , the detection inlet partition 54 has a certain hardness and thickness, and is provided with a cutout, and the cut surfaces of the cutout are in an interference fit, so that there is no pressure or insufficient pressure. , the entire incision is in a closed state, which can block the flow of liquid, but when one side of the incision is under pressure, the incision will open in the direction of the pressure for natural pressure relief, that is, when one side of the incision is under pressure With a certain amount of sample, or by applying a certain pressure to the sample, the incision can be punched, so that the collection chamber and the detection area 45 are in fluid communication. When the pressure is removed, the incision can be closed again.

检测区域Detection area

检测区域45在本实用新型是用来对液体样本进行分析测试的是否存在被分析物质。一般，在检测区域45里面可以包括测试元件，该测试元件和液体样本进行接触进行对液体样本的化验或者测试。在传统的产品中，一般在制造带有检测腔的装置的时候，一般都是先制作测试元件或者让测试元件设置在载体上，然后再把测试元件插入到检测区域中，然后再密封检测区域。在这种情况下，检测区域一般具有一个开口让测试元件能够出入到检测区域中。例如如图1-2、20-21所示，检测区域45的上端设有一个测试元件入口65，如前所述的，通过这个测试元件入口65可以让测试元件插入到检测区域45内。通常情况下，插入到检测腔后，需要对检测区域的开口65进行密封，这种密封效果和质量要求非常高，正如前面所阐述的，整个检测装置或者收集装置都需要一起进行运输和包装，为了避免位于检测区域的液体或者第三腔的液体不至于泄露，需要对任何可能产生泄露的地方进行严格密封，而且每一个产品都需要进行密封性的检测，这样增加了生产成本。但是采用本实用新型的具有二次确认的第二腔后，对这些以前考虑需要密封效果好的地方就可以不用刻意去考虑，这种密封只需要暂时的密封就够了，而且不需要要求持久性的密封。例如图24-25所示，对于收集口49和测试元件入口65的密封可以采用密封连接盖66，密封连接盖66包括用于盖住样本收集入口第一盖67和用于盖住测试元件入口65的第二盖68，通过第一盖67和第二盖68，密封连接盖66可以同时将收集口49和测试元件入口65盖住，密封连接盖66的密封就采用常规的密封就可以了，例如第一盖67和第二盖68卡接配合在第三腔和检测区域的开口部。除了图中所示的方式之外，还可以用薄膜进行热塑封，只要保证在检测的时候，该薄膜密封不透气或者不漏液就可以了，当完成检测后，让第二腔与装置主体分离后，装置主体(包括检测区域)可以作丢弃处理，而不必对整个检测装置进行储藏和运输。在一些优选的方式中，密封连接盖66上还可以设置如图24-25所示的与盖体配合的连接部位69，在一些优选的方式中，连接部位69可以采用螺纹连接，例如图中所示的形式，当然，连接部位69也可以采用其他任何形式的连接，只要能够实现密封连接盖66和盖体63的连接即可。当然，密封连接盖66本身也可以作为装置的盖体，此时不需要连接部位69，而是直接将密封连接盖66做成可以密封整个装置的形状。In the present invention, the detection area 45 is used to analyze the liquid sample to test whether there is an analyte substance. Typically, a test element may be included within the detection region 45 that is brought into contact with the liquid sample to perform an assay or test on the liquid sample. In traditional products, when a device with a detection cavity is generally manufactured, the test element is generally fabricated first or the test element is arranged on the carrier, and then the test element is inserted into the detection area, and then the detection area is sealed. . In this case, the detection area typically has an opening to allow the test element to enter and exit the detection area. For example, as shown in FIGS. 1-2 and 20-21 , the upper end of the detection area 45 is provided with a test element inlet 65 , through which the test element can be inserted into the detection area 45 as described above. Usually, after being inserted into the detection cavity, the opening 65 of the detection area needs to be sealed. The sealing effect and quality requirements are very high. As explained above, the entire detection device or collection device needs to be transported and packaged together. In order to prevent the liquid in the detection area or the liquid in the third chamber from leaking, it is necessary to strictly seal any place where leakage may occur, and each product needs to be tested for tightness, which increases the production cost. However, after adopting the second cavity with the second confirmation of the present invention, it is not necessary to deliberately consider the places that need a good sealing effect before. This kind of sealing only needs a temporary sealing, and it does not require a permanent seal. Sexual seal. For example, as shown in FIGS. 24-25 , a sealing connection cover 66 can be used to seal the collection port 49 and the test element inlet 65. The sealing connection cover 66 includes a first cover 67 for covering the sample collection inlet and a first cover 67 for covering the test element inlet. The second cover 68 of 65, through the first cover 67 and the second cover 68, the sealing connection cover 66 can cover the collection port 49 and the test element inlet 65 at the same time, and the sealing of the sealing connection cover 66 can be done by using conventional sealing. For example, the first cover 67 and the second cover 68 are snap-fitted to the opening of the third cavity and the detection area. In addition to the method shown in the figure, the film can also be used for thermoplastic sealing, as long as it is ensured that the film is air-tight or liquid-tight during the test. After the test is completed, let the second cavity and the device body be sealed. After separation, the main body of the device (including the detection area) can be disposed of without having to store and transport the entire detection device. In some preferred manners, the sealing connection cover 66 can also be provided with a connection part 69 that cooperates with the cover body as shown in Figs. In the form shown, of course, the connection portion 69 can also adopt any other form of connection, as long as the connection between the cover 66 and the cover body 63 can be sealed and connected. Of course, the sealing connection cover 66 itself can also be used as the cover body of the device. In this case, the connection part 69 is not needed, and the sealing connection cover 66 is directly made into a shape that can seal the entire device.

用于收集确认检测样本的第二腔Second chamber for collection of confirmatory test samples

在本实用新型的一些具体实施方式中，本实用新型提供一种用于收集确认检测样本的第二腔42。在一些优选的方式中，第二腔42能够收集与初始检测样本同一批次的样本，也就是说，在采集初始样本的同时，也可以向第二腔42装入同一批次的样本。在一些优选的方式中，第二腔42内的样本来自于第一腔41。在一些优选的方式中，第二腔42内的样本来自第三腔43。在一些优选的方式中，第二腔42可以直接收集样本。In some embodiments of the present invention, the present invention provides a second chamber 42 for collecting confirmation test samples. In some preferred manners, the second chamber 42 can collect samples of the same batch as the initial detection samples, that is, while collecting the initial samples, the second chamber 42 can also be filled with samples of the same batch. In some preferred manners, the sample in the second chamber 42 comes from the first chamber 41 . In some preferred manners, the sample in the second chamber 42 comes from the third chamber 43 . In some preferred ways, the second chamber 42 can directly collect the sample.

作为第二腔的具体实现方式，如图12-15所示，第二腔42是一个体积可变的腔体，这个腔体具有一个开口端55，在一些优选的方式中，开口端55不能被压缩，如图13所示，开口端55内设有一个开口，这个开口56可以时第二腔42与其他腔体连通从而通过其他腔体收集样本，或者这个开口可以允许第二腔42自行收集样本。在一些优选的方式中，这个开口56可以被密封件57密封，如图14所示，当被密封件密封时，密封件57能够与开口56固连、紧配或可拆式连接或结合。在一些优选的方式中，连通器58和第二腔42的连通方式可以是以刺破元件刺破57来实现。As a specific implementation of the second cavity, as shown in FIGS. 12-15 , the second cavity 42 is a cavity with a variable volume, and this cavity has an open end 55 . In some preferred ways, the open end 55 cannot is compressed, as shown in FIG. 13, there is an opening in the open end 55, this opening 56 can allow the second cavity 42 to communicate with other cavities to collect samples through other cavities, or this opening can allow the second cavity 42 to self- Collect samples. In some preferred manners, the opening 56 can be sealed by a sealing member 57 , as shown in FIG. 14 , when the sealing member 57 is sealed by the sealing member, the sealing member 57 can be firmly connected, tightly fitted or detachably connected or combined with the opening 56 . In some preferred manners, the communication between the connector 58 and the second cavity 42 may be achieved by piercing the piercing element 57 .

在一些优选的方式中，开口端55也可以被压缩，在这种情况下，可以不单独设置密封件，直接将开口端与第二腔42一体成型，或者设置能够随开口端55一同被压缩的密封件，此时密封件需要具有一定的弹性或者伸缩性。In some preferred manners, the open end 55 can also be compressed. In this case, the open end and the second cavity 42 can be directly integrally formed without a separate seal, or the open end 55 can be compressed together with the open end 55. At this time, the seal needs to have certain elasticity or stretchability.

在一些优选的方式中，第二腔42可以具有一个自密封的开口，如前所述，这个开口在一定范围的压力下能够处于密封的状态，确保第二腔42内的液体不会流出，但是在压力超过一定数值，则有可能会打开，当超过这个数值的压力撤除后，又会恢复到密封的状态。In some preferred manners, the second cavity 42 may have a self-sealing opening. As mentioned above, the opening can be in a sealed state under a certain range of pressure to ensure that the liquid in the second cavity 42 will not flow out, However, when the pressure exceeds a certain value, it may be opened, and when the pressure exceeding this value is removed, it will return to a sealed state.

在一些优选的方式中，密封件57可以是橡胶塞或者塑胶塞或者硅胶塞，其具材质具有一定的弹性，在被刺破的时候能够通过刺破元件与外界或者其他腔体连通，当刺破元件撤除之后，又能够恢复密封，恢复后的密封可以保证在一定压力范围内，其中的液体不会渗漏。In some preferred manners, the sealing member 57 can be a rubber plug, a plastic plug or a silicone plug, which has a certain elasticity and can communicate with the outside world or other cavities through the piercing element when it is pierced. After the breaking element is removed, the seal can be restored, and the restored seal can ensure that the liquid in it will not leak within a certain pressure range.

在一些优选的方式中，第二腔42内可以被抽真空，这样，由于第二腔42没有内压，一旦与其他腔体或者外界连通，则会有利于样本向第二腔42内流入。In some preferred manners, the second chamber 42 can be evacuated. In this way, since the second chamber 42 has no internal pressure, once it communicates with other chambers or the outside world, it will facilitate the flow of the sample into the second chamber 42 .

在一些优选的方式中，第二腔42在被装入液体样本后其形状和体积会发生改变，如图18-19所示，当第二腔42被装入一定量的液体样本后，其形状从扁平状扩张为圆柱状。由于第二腔42具有这样的伸缩性或弹性，并且在装入样本时其开口端被刺破元件刺破，因此第二腔42内装入的样本在需要使用时，可以挤压第二腔42使其从被刺破元件刺破的开口端流出。In some preferred manners, the shape and volume of the second cavity 42 will change after being filled with liquid samples. As shown in FIGS. 18-19 , when the second cavity 42 is filled with a certain amount of liquid samples, its The shape expands from flat to cylindrical. Since the second cavity 42 has such stretchability or elasticity, and the open end of the second cavity 42 is punctured by the piercing element when the sample is loaded, the sample loaded in the second cavity 42 can squeeze the second cavity 42 when it needs to be used. It flows out of the open end pierced by the piercing element.

在一些优选的方式中，第二腔也可以是硬质腔体，例如采用玻璃或者塑料材料制成，密封件57上可以设置能够自密封的开口，例如，类似“尖叫瓶”的开口。在一些优选的方式中，自密封的开口可以直接设置在第二腔上。In some preferred manners, the second cavity can also be a hard cavity, for example, made of glass or plastic material, and the sealing member 57 can be provided with a self-sealing opening, for example, an opening similar to a "screaming bottle". In some preferred forms, the self-sealing opening may be provided directly on the second cavity.

连通器connector

如图9-11所示，在本实用新型的一些具体实现方式中，本实用新型还提供一种用于连通第二腔42和第一腔41的连通器58。在一些优选的方式中，连通器58与第二腔42可拆式的连接或者结合。在一些优选的方式中，当腔体和连通器连接或者结合时，连通器能够将腔体内部与其他腔体或者外部液体连通。在一些优选的方式中，当腔体和连通器拆开时，腔体处于自密封的状态。在一些优选的方式中，连通器58用于连通第二腔42和其他腔体，例如第一腔41，或者是第三腔43。在一些优选的方式中，连通器58用于连通第二腔42和外部空间。As shown in FIGS. 9-11 , in some specific implementations of the present invention, the present invention further provides a communicating device 58 for connecting the second cavity 42 and the first cavity 41 . In some preferred manners, the connector 58 is detachably connected or combined with the second cavity 42 . In some preferred manners, when the cavity and the connector are connected or combined, the connector can fluidly communicate the interior of the cavity with other cavities or the outside. In some preferred manners, when the cavity and the connector are disassembled, the cavity is in a self-sealing state. In some preferred manners, the connector 58 is used to communicate the second cavity 42 and other cavities, such as the first cavity 41 or the third cavity 43 . In some preferred modes, the connector 58 is used to communicate the second cavity 42 with the external space.

如图9所示，连通器58可以具有一个刺破元件59，这个刺破元件59能够在一定外力作用下刺破第二腔42，并为第二腔42建立一个与其他腔体或者外界连通的通道。在一些优选的方式中，刺破元件59是如图所示的针头。As shown in FIG. 9 , the communication device 58 may have a piercing element 59, which can pierce the second cavity 42 under the action of a certain external force, and establish a communication between the second cavity 42 and other cavities or the outside world channel. In some preferred modes, the piercing element 59 is a needle as shown.

在一些优选的方式中，连通器58具有一个连通腔60，刺破元件59与连通腔60连通，连通腔60本身可以和其他腔体连通，例如，连通腔60可以和第一腔41连通，当第一腔41被挤压时，其内的样本能够通过连通腔60顺着刺破元件59进入到第二腔42内，在一些优选的方式中，连通腔60也可以作为直接收集样本的入口。In some preferred manners, the communicating device 58 has a communicating cavity 60, the piercing element 59 communicates with the communicating cavity 60, and the communicating cavity 60 itself can communicate with other cavities, for example, the communicating cavity 60 can communicate with the first cavity 41, When the first cavity 41 is squeezed, the sample in it can enter the second cavity 42 along the piercing element 59 through the communication cavity 60. In some preferred manners, the communication cavity 60 can also be used as a means for directly collecting samples. Entrance.

在一些优选的方式中，连通腔60可以将第一通道47部分的容纳其中，这部分尤其包括前面所述收集槽50，如图36所示，是连通器和第一通道的一种装配方式，在这种装配方式下，连通器将第一通道和第三腔43隔断，使第一通道只能够连通第二腔42和第一腔41，此时第二腔42只能接受来自第一腔41的样本，这种方式尤其适用于其他腔体内的样本用作检测的情况，确保进入到第二腔42内作为二次检测的样本不会在初始检测的时候被污染，同时将第一通道与第三腔隔断后，第二腔的外周边不会被来自第三腔的样本污染，在第二腔完成收集并取出后，其外表面不会沾染样本。In some preferred ways, the communication cavity 60 can accommodate the first channel 47, which especially includes the aforementioned collection groove 50. As shown in FIG. 36, it is an assembly method of the communication device and the first channel. , in this assembly mode, the communication device separates the first channel and the third cavity 43, so that the first channel can only communicate with the second cavity 42 and the first cavity 41. At this time, the second cavity 42 can only accept the The sample in the cavity 41 is especially suitable for the case where the samples in other cavities are used for detection, to ensure that the samples entering the second cavity 42 for the secondary detection will not be contaminated during the initial detection, and at the same time the first After the channel is cut off from the third cavity, the outer periphery of the second cavity will not be contaminated by the sample from the third cavity, and after the second cavity is collected and taken out, the outer surface of the second cavity will not be contaminated with the sample.

在一些优选的方式中，可以为连通器58和盖体63设置一个限位结构，这个限位结构可以防止连通器58被带离盖体，因为连通器58的外壁可能会与样本发生接触，在这种情况下，当第二腔42被取出时，连通器58最好不要和第二腔42同时被带出，否则会有样本，也就是说，在第二腔42取出的同时，要实现第二腔42与连通器58的分离，这种分离可以通过限位结构限制连通器的移动来实现。在一些优选的方式中，限位结构可以设置在盖体63上。在一些优选的方式中，限位结构可以设置在连通器58上。In some preferred manners, a limit structure can be provided for the communication connector 58 and the cover body 63, which can prevent the communication connector 58 from being taken away from the cover body, because the outer wall of the communication connector 58 may come into contact with the sample, In this case, when the second cavity 42 is taken out, it is better not to take out the communication connector 58 and the second cavity 42 at the same time, otherwise there will be samples, that is, when the second cavity 42 is taken out, it is necessary to The separation of the second cavity 42 and the communication device 58 is realized, and the separation can be realized by restricting the movement of the communication device through the limiting structure. In some preferred manners, the limiting structure may be provided on the cover body 63 . In some preferred manners, the limiting structure may be provided on the communicating connector 58 .

在一些优选的方式中，连通器58的端面上具有一个台阶面61，台阶面61可以作为连通器58罩在第一通道47上的一个基准面，并且，当第二腔完成样本收集后，连通器58由于刺破元件59的作用是会连接在第二腔42上的，此时需要将第二腔和连通器58分离，也即需要施加一定的外力，但由于连通器本身已经被样本沾染，不能手动操作，在这种情况下，由于台阶面61的突出，可以通过盖体63上第二腔的装配结构62对这个台阶面61的作用，确保在第二腔42分离时，连通器58仍然留在装置内，不会随之被拔出。此外，连通器58上还具有一个锥形面64，锥形面的主要作用是便于连通器58的安装。In some preferred manners, the end face of the communicating device 58 has a stepped surface 61, and the stepped surface 61 can be used as a reference surface for the communicating connector 58 to cover the first channel 47, and when the second chamber completes the sample collection, The communicating device 58 will be connected to the second cavity 42 due to the action of the piercing element 59. At this time, it is necessary to separate the second cavity and the communicating device 58, that is, a certain external force needs to be applied, but since the communicating device itself has been sampled by the sample. In this case, due to the protrusion of the stepped surface 61, the assembly structure 62 of the second cavity on the cover 63 can act on the stepped surface 61 to ensure that when the second cavity 42 is separated, the communication The device 58 remains in the device and cannot be removed therewith. In addition, the communication connector 58 also has a tapered surface 64 , and the main function of the tapered surface is to facilitate the installation of the communication connector 58 .

如图3-4所示，在本实用新型的一个具体实施方式中，连通器58在初始使用时，可以被装在盖体63上第二腔的装配结构62的下端，随着盖体63的盖合套在第一通道47上。在初始使用或者初始装配的时候，连通器58并不连通第二腔，只有当需要收集二次确认检测的样本时，连通器58才会在一定的作用下连通第二腔。As shown in FIGS. 3-4 , in a specific embodiment of the present invention, the communication connector 58 can be installed on the lower end of the assembly structure 62 of the second cavity on the cover body 63 during initial use, along with the cover body 63 . The cover is sleeved on the first channel 47 . During initial use or initial assembly, the communication connector 58 does not communicate with the second cavity, and only when a sample for secondary confirmation testing needs to be collected, the communication connector 58 will communicate with the second cavity under a certain action.

例如图7-8和36所示的状态，是连通器58尚未与第二腔42连通的状态，此时第二腔42内尚未收集到液体样本，在这种配合状态下，通过配合关系或者外力将连通器58向第二腔42的方向推动，则连通器58上的刺破元件59能够刺破第二腔的外壁或者刺破第二腔上的密封件57与第二腔液体连通。又如图19所示的状态，可以理解为是连通器58从第二腔拔出的状态，此时第二腔内已收集到足够量的液体样本，此时拔出连通器58，第二腔被刺破的外壁或者第二腔的密封件57能够自然闭合，这个自然闭合的状态能够承受其内所收集到的液体样本的压力。需要使用时，挤压第二腔，液体样本可以从被刺破处流出。For example, the state shown in FIGS. 7-8 and 36 is a state in which the communication device 58 has not yet communicated with the second cavity 42, and the liquid sample has not yet been collected in the second cavity 42. In this matching state, through the matching relationship or When the external force pushes the communication connector 58 toward the second cavity 42, the piercing element 59 on the communication connector 58 can pierce the outer wall of the second cavity or pierce the seal 57 on the second cavity to communicate with the second cavity. The state shown in FIG. 19 can be understood as the state in which the communication device 58 is pulled out from the second cavity. At this time, a sufficient amount of liquid samples has been collected in the second cavity. At this time, the communication device 58 is pulled out, and the second cavity The pierced outer wall of the cavity or the seal 57 of the second cavity can be closed naturally, and this naturally closed state can withstand the pressure of the liquid sample collected therein. When needed, squeeze the second chamber and the liquid sample can flow out of the puncture.

盖体cover

如图3-6所示，在本实用新型的一些具体实施方式中，本实用新型提供一种盖体63，在一些优选的方式中，如图2所示，盖体63可以连接在密封连接盖66上，盖体63与密封连接盖66可以通过连接部位69可拆式的结合或者连接，也就是说，盖体63可以盖合在密封连接盖66上，也可以从其上取下。在一些优选的方式中，可以不设置密封连接盖66，盖体63直接盖合在第三腔43的口部，盖体63也可以与第三腔43的口部可拆式的结合或者连接，当盖体63盖合时，能够将本实用新型的样本收集装置整体密封。如前所述，这种密封可以是普通的密封，也可以是要求较高的密封结构，根据实际的需求选择。As shown in FIGS. 3-6 , in some specific embodiments of the present invention, the present invention provides a cover body 63 . In some preferred ways, as shown in FIG. 2 , the cover body 63 can be connected in a sealed connection On the cover 66, the cover body 63 and the sealing connection cover 66 can be detachably combined or connected through the connection part 69, that is, the cover body 63 can be covered on the sealing connection cover 66 or removed therefrom. In some preferred manners, the sealing connection cover 66 may not be provided, the cover body 63 is directly covered with the mouth of the third cavity 43 , and the cover body 63 may also be detachably combined or connected with the mouth of the third cavity 43 . , when the cover body 63 is closed, the sample collection device of the present invention can be completely sealed. As mentioned above, this kind of seal can be an ordinary seal, or it can be a sealing structure with higher requirements, which can be selected according to actual needs.

在本实用新型的一些优选的方式中，盖体63在密封配合的同时，能够将第二腔42装入，使得第二腔42处于一个能够随时采集样本的位置或者状态。当然，本实用新型并不排除在一些优选的方式中，第二腔42也可以通过其他的方式置于能够随时采集样本的位置或者状态。在一些优选的方式中，盖体63上设置第二腔的装配结构62，第二腔42能够与该装配结构62可拆式的连接或者结合，在本实用新型的装置被使用前(例如运输存储或者销售的时候)第二腔42可以与装配结构62分离，如果这种分离能够缩减本实用新型整体结构所占用的空间，然后在使用时，再将第二腔42装入到装配结构62内，第二腔能够随装配结构被装入到合适的位置。在一些优选的方式中，盖体63上设置装配通道70，第二腔的装配结构62能够与该装配通道70可拆式的结合或者连接，也就是说第二腔可以首先被装入该装配结构内，再通过该装配结构装入到盖体63内。In some preferred modes of the present invention, the cover body 63 can be installed in the second cavity 42 while the cover body 63 is sealingly fitted, so that the second cavity 42 is in a position or state where samples can be collected at any time. Of course, the present invention does not exclude some preferred ways, and the second cavity 42 can also be placed in a position or state where samples can be collected at any time in other ways. In some preferred manners, the cover body 63 is provided with a second cavity assembly structure 62, the second cavity 42 can be detachably connected or combined with the assembly structure 62, before the device of the present invention is used (for example, transported). When storing or selling) the second cavity 42 can be separated from the assembly structure 62, if this separation can reduce the space occupied by the overall structure of the present invention, then when in use, the second cavity 42 can be loaded into the assembly structure 62 Inside, the second cavity can be loaded into the appropriate position with the assembly structure. In some preferred manners, an assembly channel 70 is provided on the cover body 63, and the assembly structure 62 of the second cavity can be detachably combined or connected with the assembly channel 70, that is to say, the second cavity can be installed into the assembly first into the structure, and then loaded into the cover body 63 through the assembly structure.

在一些优选的方式中，连通器58也会被装入到装配结构62内，但是连通器58装入装配结构62并不表示其直接与第二腔42连通，如前所述的，连通器58可以根据实际使用的需要在其他配合作用或者外力作用下，与第二腔42液体连通或者分离。In some preferred manners, the connector 58 is also installed into the fitting structure 62, but the installation of the connector 58 into the fitting structure 62 does not mean that it communicates directly with the second cavity 42. As previously mentioned, the connector 58 can be in liquid communication with or separated from the second cavity 42 under the action of other cooperation or external force according to actual needs.

第二腔的装配结构Assembly structure of the second cavity

在本实用新型的一些优选的方式中，本实用新型提供一种第二腔的装配结构62，该装配结构62的主要作用是将第二腔装入其中，在本实用新型的一些优选的方式中，第二腔42是一个柔性体，其外壁能够被挤压，并且第二腔需要和盖体或者是其他的腔体进行可拆式的结合或者连接，在这种可拆式的结合或者连接的过程中，必然会对第二腔施加一定的外力，如果对第二腔这种柔性体没有一个外部的保护结构，很有可能会施力不当将其中的液体样本挤出，这是绝对需要避免的情况，因此装配结构不仅是承载第二腔，还对第二腔起到一个支撑和临时保护的作用。In some preferred modes of the present invention, the present invention provides an assembly structure 62 for the second cavity. The main function of the assembly structure 62 is to install the second cavity into it. In some preferred modes of the present invention Among them, the second cavity 42 is a flexible body, the outer wall of which can be squeezed, and the second cavity needs to be detachably combined or connected with the cover body or other cavities. In this detachable combination or During the connection process, a certain external force will inevitably be applied to the second cavity. If there is no external protective structure for the flexible body of the second cavity, it is very likely that the liquid sample will be squeezed out by improper force. This is absolutely The situation that needs to be avoided, so the assembly structure not only carries the second cavity, but also plays a supporting and temporary protection role for the second cavity.

在一些优选的方式中，第二腔也可以是硬质腔体，例如玻璃或者塑料材料制成，在这种情况下，装配结构也可以对第二腔起到一定的保护作用，更主要的是起到一个对第二腔进行抓取、握持的方便的方式。In some preferred ways, the second cavity can also be a hard cavity, such as glass or plastic material, in this case, the assembly structure can also play a certain protective role for the second cavity, more importantly It is a convenient way to grab and hold the second cavity.

在一些优选的方式中，如图7、16-17所示，装配结构具有一个外壁71和内腔72，第二腔可以被装入其内腔中，第二腔和内腔可以采用固定结合、固定连接或者可拆式结合可拆式连接的形式装配在一起。装配的目的是使得第二腔和装配结构能够作为一个整体与盖体或者其他的腔体和部件进行连接或者结合。如前所述，装配结构62需要对第二腔起到支撑和保护的作用，因此，装配结构62的外壁必须具有一定的形状和硬度，这个形状要超出第二腔的外廓形状范围，硬度要满足能够承受一定的压力而不对第二腔造成挤压，例如手指的挤压，由于第二腔的工作环境通常都是移动或者手动操作，在使用时也不会刻意去挤压第二腔或者装配结构，因此对硬度的要求也不会太高，通常的塑料材质的硬度基本上就能够满足这个要求。In some preferred manners, as shown in Figures 7, 16-17, the assembly structure has an outer wall 71 and an inner cavity 72, the second cavity can be inserted into the inner cavity, and the second cavity and the inner cavity can be fixedly combined , fixed connection or detachable combined with detachable connection form assembled together. The purpose of the assembly is to enable the second cavity and the assembly structure to be connected or combined with the cover or other cavities and components as a whole. As mentioned above, the assembly structure 62 needs to support and protect the second cavity. Therefore, the outer wall of the assembly structure 62 must have a certain shape and hardness. This shape must exceed the outer shape range of the second cavity. To be able to withstand a certain pressure without squeezing the second cavity, such as finger squeezing, because the working environment of the second cavity is usually mobile or manual operation, the second cavity will not be deliberately squeezed during use. Or the assembly structure, so the requirement for hardness is not too high, and the hardness of ordinary plastic materials can basically meet this requirement.

在一些优选的方式中，由于第二腔在释放样本时，可能会通过挤压其外壁的方式来实现，装配结构的外壁上设置一些镂空结构73，可以穿过这些镂空结构73对第二腔进行挤压。在一些优选的方式中，由于有镂空结构73的存在，装配结构本身即能够承受一定范围内的挤压变形，需要是释放样本时，只要挤压装配结构，通过装配结构对第二腔施加压力，也能够达到排出样本的目的。In some preferred ways, since the second cavity may be realized by pressing its outer wall when releasing the sample, some hollow structures 73 are arranged on the outer wall of the assembly structure, and the second cavity can be passed through these hollow structures 73 to squeeze. In some preferred manners, due to the existence of the hollow structure 73, the assembly structure itself can withstand the extrusion deformation within a certain range. When the sample needs to be released, as long as the assembly structure is pressed, pressure is applied to the second cavity through the assembly structure. , can also achieve the purpose of discharging the sample.

在一些优选的方式中，装配结构62上设有一个和第二腔的开口端55匹配的固定环74，开口端55的外壁与该固定环74的内壁固定连接、结合或者可拆式的连接或者结合，从而将第二腔固定在装配结构上。在一些优选的方式中，固定环74和开口端55均位于第二腔和装配结构的下端。In some preferred manners, the assembly structure 62 is provided with a fixing ring 74 that matches the opening end 55 of the second cavity, and the outer wall of the opening end 55 is fixedly connected, combined or detachably connected to the inner wall of the fixing ring 74 Or combined, thereby securing the second cavity on the assembly structure. In some preferred modes, both the retaining ring 74 and the open end 55 are located at the lower end of the second cavity and assembly structure.

在一些优选的方式中，装配结构62与盖体63可拆式的结合或者连接。在一些优选的方式中，装配结构62上设有一个装配连接件75，装配连接件75能够与盖体可拆式的结合或者连接，在一些优选的方式中，装配连接件75通过螺纹与盖体63可拆式的结合或者连接，在另一些优选的方式中，装配连接件75也可以通过其他的可拆卸的连接方式与盖体进行连接。In some preferred manners, the assembly structure 62 is detachably combined or connected with the cover body 63 . In some preferred modes, the assembly structure 62 is provided with an assembly connector 75, and the assembly connector 75 can be detachably combined or connected with the cover body. In some preferred modes, the assembly connector 75 is connected to the cover through threads. The body 63 is detachably combined or connected, and in some other preferred manners, the assembly connector 75 can also be connected to the cover body through other detachable connection manners.

在一些优选的方式中，为了第二腔的分离和装入方便，如图16-17所示，装配结构62上设有一个旋钮76，如图1-3所示，当装配结构被装入到盖体63上之后，旋钮76是露出于盖体的外表面的，反向转动旋钮76可以将装配结构和第二腔从中取出，应当说明的是，旋钮76只是一种可能的实现方式，实际上，把手、拨片、挂环等具体的实现形式都能够实现这种功能，只要有一个元件，能够露出于盖体的外表面，便于第二腔的装入和分离即可，本实用新型并不限定这个元件的具体形式。In some preferred ways, in order to facilitate the separation and installation of the second cavity, as shown in Figures 16-17, a knob 76 is provided on the assembly structure 62, as shown in Figures 1-3, when the assembly structure is installed After being on the cover body 63, the knob 76 is exposed on the outer surface of the cover body, and the assembly structure and the second cavity can be taken out by turning the knob 76 in the opposite direction. It should be noted that the knob 76 is only a possible implementation. In fact, the specific implementation forms such as the handle, the pick, the hanging ring, etc. can all realize this function. As long as there is one element, it can be exposed on the outer surface of the cover body to facilitate the loading and separation of the second cavity. The novelty does not limit the specific form of this element.

在一些优选的方式中，第二腔的密封件57可以固定在装配结构62上，例如设置在固定环74处，或者设置在固定环74外，或者其他穿过密封件57即能够连通第二腔42内部的位置上。In some preferred manners, the seal 57 of the second cavity can be fixed on the assembly structure 62 , for example, at the fixing ring 74 , or outside the fixing ring 74 , or through the seal 57 to be able to communicate with the second cavity position inside the cavity 42 .

第一通道first channel

在一些优选的方式中，本实用新型的第一腔并不是直接具有对外的收集口，而是通过其他的腔室，例如第三腔43来接收液体样本，在这种情况下，第一腔和第三腔之间处于液体连通的状态。在一些优选的方式中，第一腔和第三腔直接连通。在一些优选的方式中，第一腔和第三腔通过一个第一通道47连通，如图27-29所示，第一通道47的作用是使第一腔和第三腔实现液体连通，流体可以通过该第一通道从第三腔进入第一腔。例如在图中所示的方式中，这个第一通道47位于第三腔43的底部，这样，进入到第三腔内的样本可以在自身重力的作用下自然流入到第一腔内。第一通道47与第三腔43直接连通，并且，第一腔41位于第三腔43的下方，第三腔43具有一个向上的收集口49，通过该收集口49，液体样本可以进入到第三腔43内并在重力作用下自然下落或者往下流，自然下落并进入第一通道的那部分液体样本可以直接落入第一腔41内，在自然下落过程中必然有一部分液体样本是无法直接落入第一通道47的，那么这部分液体样本可以在第三腔43的底部集聚，当液面高度超过从第一通道47高出第三腔43底部的高度时，这部分液体便会通过第一通道47流入到第一腔41内。在一些优选的方式中，样本也可以从第一腔进入第三腔。In some preferred manners, the first chamber of the present invention does not directly have an external collection port, but receives liquid samples through other chambers, such as the third chamber 43 , in this case, the first chamber It is in a state of liquid communication with the third cavity. In some preferred manners, the first cavity and the third cavity are in direct communication. In some preferred manners, the first cavity and the third cavity are communicated through a first channel 47. As shown in Figures 27-29, the function of the first channel 47 is to make the first cavity and the third cavity communicate with each other in liquid, and the fluid The first cavity can be accessed from the third cavity through the first passage. For example, in the manner shown in the figure, the first channel 47 is located at the bottom of the third cavity 43, so that the sample entering the third cavity can naturally flow into the first cavity under the action of its own gravity. The first channel 47 is in direct communication with the third cavity 43, and the first cavity 41 is located below the third cavity 43. The third cavity 43 has an upward collection port 49, through which the liquid sample can enter the third cavity 49. The three chambers 43 fall naturally or flow downward under the action of gravity. The part of the liquid sample that falls naturally and enters the first channel can directly fall into the first chamber 41. During the natural falling process, there must be a part of the liquid sample that cannot be directly If the liquid sample falls into the first channel 47, this part of the liquid sample can accumulate at the bottom of the third cavity 43. When the liquid level exceeds the height from the first channel 47 above the bottom of the third cavity 43, this part of the liquid will pass through The first channel 47 flows into the first cavity 41 . In some preferred manners, the sample can also enter the third chamber from the first chamber.

在一些优选的方式中，例如，从图中可以看出的，在第一通道47的侧壁上可以开设一个收集槽50，这个收集槽50可以与第三腔43的底部齐平或者略高于第三腔的底部，在自然下落过程中并未进入第一通道47的那部分液体样本会最终汇集到第三腔43的底部，由于收集槽与第三腔43的底部高度比较接近，在第三腔43底部的液体样本很大可能会通过收集槽50进入到第一通道47内从而顺着第一通道47流入到第一腔41内。需要说明的是，由于我们并不需要第三腔43内所有的样本都流入到第一腔41内，只需要其中的一部分，因此，只要收集到的液体的量足够，必然会有一部分样本会进入到第一通道47内，并且，由于实际使用中，整个腔体可能会处于一个非静止的状态，例如被手持，那么所采集到的样本也会由于摇晃而更大可能地进入到收集槽50内。In some preferred ways, for example, as can be seen from the figure, a collection groove 50 may be opened on the side wall of the first channel 47 , and this collection groove 50 may be flush with the bottom of the third cavity 43 or slightly higher At the bottom of the third cavity, the part of the liquid sample that did not enter the first channel 47 during the natural fall will eventually collect at the bottom of the third cavity 43. Since the height of the collection tank is relatively close to the bottom of the third cavity 43, at the bottom of the third cavity 43 The liquid sample at the bottom of the third cavity 43 is likely to enter the first channel 47 through the collection groove 50 and flow into the first cavity 41 along the first channel 47 . It should be noted that, since we do not need all the samples in the third chamber 43 to flow into the first chamber 41, only a part of them is needed. Therefore, as long as the amount of collected liquid is sufficient, a part of the samples will inevitably flow into the first chamber 41. Enter into the first channel 47, and, due to actual use, the entire cavity may be in a non-stationary state, such as being held by hand, then the collected sample will also be more likely to enter the collection tank due to shaking within 50.

在一些优选的方式中，第一通道47可以被封闭，例如在第一腔内的样本向第二腔中转移，或者第二腔被取出以及放入时，由于第二腔是用于收集二次确认检测的液体样本的，当第一通道被封闭时，第一腔和第三腔处于液体隔断状态，例如，在一些优选的方式中，样本首先进入第三腔，并可沿前述的第一通道流入第一腔，第一腔内的液体可以在外力作用下进入到第二腔内，在一些优选的方式中，第一腔和第二腔处于液体连通的状态时，第一通道可以被封闭。在一些优选的方式中，如图36所示，可以通过连通器将第一通道封闭，在这种装配方式下，连通器将第一通道和第三腔43隔断，使第一通道只能够连通第二腔42和第一腔41，此时第二腔42只能接受来自第一腔41的样本，这种方式尤其适用于其他腔体内的样本用作检测的情况，确保进入到第二腔42内作为二次检测的样本不会在初始检测的时候被污染，同时将第一通道与第三腔隔断后，第二腔的外周边不会被来自第三腔的样本污染，在第二腔完成收集并取出后，其外表面不会沾染样本。In some preferred ways, the first channel 47 can be closed, for example, when the sample in the first cavity is transferred to the second cavity, or when the second cavity is taken out and put in, since the second cavity is used to collect two When the first channel is closed, the first cavity and the third cavity are in a liquid blocking state. For example, in some preferred ways, the sample first enters the third cavity, and can follow the above-mentioned No. A channel flows into the first cavity, and the liquid in the first cavity can enter the second cavity under the action of external force. is closed. In some preferred manners, as shown in FIG. 36 , the first channel can be closed by a communicating device. In this assembly mode, the communicating device blocks the first channel and the third cavity 43 so that the first channel can only communicate with each other. The second cavity 42 and the first cavity 41. At this time, the second cavity 42 can only accept samples from the first cavity 41. This method is especially suitable for the case where the samples in other cavities are used for detection, ensuring that the samples enter the second cavity. The samples in 42 for secondary detection will not be contaminated during the initial detection, and after the first channel is isolated from the third cavity, the outer periphery of the second cavity will not be contaminated by the samples from the third cavity. After the chamber has been collected and removed, the outer surface of the chamber is free of sample contamination.

第四腔fourth chamber

在一些优选的方式中，本实用新型提供一种用于暂存检测样本的第四腔，如图27-28所示，第四腔内的样本主要用于初次检测。在一些优选的方式中，直接从第四腔内对样本进行检测。在一些优选的方式中，将第四腔内的样本推入到检测区域内进行检测。在一些优选的方式中，第四腔可以直接收集样本。在一些优选的方式中，第四腔可以通过其他的腔室收集样本。In some preferred manners, the present invention provides a fourth chamber for temporarily storing detection samples. As shown in FIGS. 27-28 , the samples in the fourth chamber are mainly used for initial detection. In some preferred ways, the sample is detected directly from the fourth chamber. In some preferred manners, the sample in the fourth chamber is pushed into the detection area for detection. In some preferred ways, the fourth chamber can directly collect the sample. In some preferred ways, the fourth chamber can collect samples through the other chambers.

当第四腔通过其他腔室收集样本时，在一些优选的方式中，第四腔能够与第三腔处于液体连通或隔断的状态。在一些优选的方式中，当第四腔与第三腔处于液体连通状态时，第三腔内收集的液体能够同时进入第四腔，第四腔也可以与第三腔在初始收集样本的时候就处于连通的状态，例如，如图27-28所示，第四腔位于第三腔的底部，第三腔的底部设有与第四腔连通的开口，这样，进入到第三腔的液体样本就能够在重力作用下直接流入第四腔，第四腔也可以和第三腔基本上同步地完成所需要的样本。在一些优选的方式中，第四腔可以和第三腔直接连通。在一些优选的方式中，第四腔可以通过第二通道与第三腔液体连通。When the fourth chamber collects samples through other chambers, in some preferred manners, the fourth chamber can be in a state of liquid communication or isolation with the third chamber. In some preferred manners, when the fourth chamber and the third chamber are in liquid communication state, the liquid collected in the third chamber can enter the fourth chamber at the same time, and the fourth chamber can also be connected with the third chamber when the sample is initially collected. It is in a connected state. For example, as shown in Figures 27-28, the fourth cavity is located at the bottom of the third cavity, and the bottom of the third cavity is provided with an opening that communicates with the fourth cavity, so that the liquid entering the third cavity The sample can directly flow into the fourth chamber under the action of gravity, and the fourth chamber can also complete the required sample substantially synchronously with the third chamber. In some preferred manners, the fourth cavity may communicate directly with the third cavity. In some preferred manners, the fourth chamber may be in fluid communication with the third chamber through the second channel.

在一些优选的方式中，第四腔能够与检测区域处于液体连通或隔断的状态，当第四腔在初始收集的时候，第四腔与检测区域可以被隔离开来，也就是说，收集和检测可以是相互独立的环节。在一些优选的方式中，第四腔和检测区域的隔离和连通可以通过检测入口来实现。如前所述，检测入口46是收集腔和检测区域之间的连通口，但是，不需要将检测区域和收集腔时刻连通，收集腔可以和检测区域分隔开，并根据需要连通，在这种情况下，可以在检测入口46设置检测入口隔断件54，通过检测入口隔断件54来实现检测入口46可以被调整或者设置为连通或者隔断的功能，这样就可以根据需要将第三腔43内的液体引入到检测区域45内。In some preferred manners, the fourth chamber can be in a state of liquid communication or isolation with the detection area, and when the fourth chamber is initially collected, the fourth chamber and the detection area can be isolated, that is, the collection and Detection can be independent of each other. In some preferred manners, the isolation and communication between the fourth chamber and the detection area can be achieved through the detection inlet. As mentioned above, the detection inlet 46 is the communication port between the collection chamber and the detection area. However, it is not necessary to connect the detection area and the collection chamber at all times. The collection chamber can be separated from the detection area and communicated as required. In this case, the detection inlet partition 54 can be set at the detection inlet 46, and the detection inlet 46 can be adjusted or set to be connected or blocked by the detection inlet partition 54, so that the third cavity 43 can be installed according to needs. The liquid is introduced into the detection area 45 .

例如，如图27所示的方式中，检测入口隔断件54具有一定的硬度和厚度，其上设有切口，切口的切面之间是过盈配合的，那么在没有压力或者压力不足的情况下，整个切口是处于闭合的状态，可以隔断液体流通，但是当切口的一侧受到压力的情况下，切口就会顺着压力的方向敞开，进行自然泄压，也就是说，当切口的一侧有一定量的样本，或者对样本施加一定的压力，就可以冲开切口，使收集腔和检测区域45液体连通，当压力撤除之后，切口又可以恢复闭合的状态。For example, in the manner shown in FIG. 27 , the detection inlet partition 54 has a certain hardness and thickness, and is provided with a cutout, and the cut surfaces of the cutout are in an interference fit, so that there is no pressure or insufficient pressure. , the entire incision is in a closed state, which can block the flow of liquid, but when one side of the incision is under pressure, the incision will open in the direction of the pressure for natural pressure relief, that is, when one side of the incision is under pressure With a certain amount of sample, or by applying a certain pressure to the sample, the incision can be punched, so that the collection chamber and the detection area 45 are in fluid communication. When the pressure is removed, the incision can be closed again.

在一些优选的方式中，当第四腔44与检测区域45处于液体连通状态时，第四腔44和第三腔43处于液体隔断状态，一方面可以确保检测区域不被其他腔室可能造成的污染影响，另一方面可以实现定量检测，只要设定第四腔的体积，就可以实现对进入检测区域的样本的定量。In some preferred ways, when the fourth cavity 44 and the detection area 45 are in liquid communication state, the fourth cavity 44 and the third cavity 43 are in a liquid isolation state, on the one hand, it can ensure that the detection area is not caused by other chambers. On the other hand, quantitative detection can be realized. As long as the volume of the fourth chamber is set, the quantification of the sample entering the detection area can be realized.

第二通道second channel

如前所述，第二通道48的作用是使第四腔44和第三腔43实现液体连通，从而使第四腔44能够和第三腔43同步收集样本。在一些优选的方式中，考虑到这部分样本本身要避免污染性，这部分样本在检测的时候要避免与其他腔体内的样本接触，以及这部分样本在接触了检测区域的测试元件之后不要回流的问题，当第四腔内的样本被转移到检测区域的时候，第二通道也同时被封闭。例如，如图28所示的状态，第二移液元件53的初始位置处于第二通道48下方的一侧，在第四腔44收集样本的过程中，第二通道所处的位置不变，当需要将样本推入检测区域时，第二移液元件53向靠近检测区域45的方向移动，此时也是一个逐渐封闭第二通道48的过程。在一些优选的方式中，第二通道48与检测区域之间的距离小于第二移液元件53本身的长度，这样，在完成移液后，第二通道48仍然处于被第二移液元件53封闭的状态。As mentioned above, the function of the second channel 48 is to make the fourth chamber 44 and the third chamber 43 communicate with each other in liquid, so that the fourth chamber 44 and the third chamber 43 can collect samples synchronously. In some preferred ways, considering that this part of the sample itself should avoid contamination, this part of the sample should avoid contact with samples in other cavities during detection, and this part of the sample should not flow back after touching the test element in the detection area. The problem is that when the sample in the fourth chamber is transferred to the detection area, the second channel is also closed at the same time. For example, in the state shown in FIG. 28, the initial position of the second pipetting element 53 is on the side below the second channel 48. During the process of collecting the sample in the fourth chamber 44, the position of the second channel remains unchanged. When the sample needs to be pushed into the detection area, the second pipetting element 53 moves toward the direction close to the detection area 45, which is also a process of gradually closing the second channel 48 at this time. In some preferred manners, the distance between the second channel 48 and the detection area is smaller than the length of the second pipetting element 53 itself, so that after pipetting is completed, the second channel 48 is still in the position of being blocked by the second pipetting element 53 . closed state.

第一移液元件、第二移液元件、移液通道和移液塞First pipetting element, second pipetting element, pipetting channel and pipette stopper

本实用新型提供移液元件，移液元件的作用是使第一腔41内的液体向第二腔42内转移。在一些优选的方式中，移液元件也能够使第四腔44内的液体向检测区域45转移，上述两种转移可以是同步的，也可以是相互独立的过程。The utility model provides a pipetting element, and the function of the pipetting element is to transfer the liquid in the first cavity 41 to the second cavity 42 . In some preferred manners, the pipetting element can also transfer the liquid in the fourth chamber 44 to the detection area 45 , and the above two transfers can be synchronous or independent processes.

在一些优选的方式中，如图27-29、31-34所示，移液元件包括用于将第一腔41内的样本转移到第二腔42内的第一移液元件52，以及，将第四腔44内的样本转移到检测区域45的第二移液元件53，第一移液元件52和第二移液元件53可以独立移动也可以联动，第一移液元件52和第二移液元件53通常是被推动移动然后对各自腔体内的液体产生推力，使这些样本转移到其他的腔体或者区域内。例如，第一移液元件52能够在外力作用下移动从而挤压第一腔51内的样本，对其产生压力，使其向所需要的方向或者腔室进行转移，例如通过连通器58进入到第二腔内。在一些优选的方式中，第二移液元件53能够在外力作用下移动从而挤压第四腔44体内的样本，对其产生压力，使其向所需要的方向或者腔室进行转移，例如进入到检测区域45内。In some preferred modes, as shown in Figures 27-29, 31-34, the pipetting element includes a first pipetting element 52 for transferring the sample in the first chamber 41 to the second chamber 42, and, The sample in the fourth chamber 44 is transferred to the second pipetting element 53 in the detection area 45. The first pipetting element 52 and the second pipetting element 53 can move independently or in linkage. The first pipetting element 52 and the second pipetting element 53 can move independently. The pipetting elements 53 are usually pushed to move and then push the liquid in their respective chambers, so that the samples are transferred to other chambers or regions. For example, the first pipetting element 52 can be moved under the action of an external force to squeeze the sample in the first chamber 51 to generate pressure and transfer it in a desired direction or chamber, for example, through the connector 58 into the in the second cavity. In some preferred manners, the second pipetting element 53 can move under the action of an external force to squeeze the sample in the fourth chamber 44 to generate pressure to transfer it to a desired direction or chamber, such as entering into the fourth chamber 44 into the detection area 45 .

在一些优选的方式中，第一移液元件52和第一腔41处于同一移液通道51内，推动第一移液元件可以实现上述的挤压。在一些优选的方式中，第二移液元件和第四腔处于同一移液通道内，推动第二移液元件可以实现上述的挤压。在一些优选的方式中，第一移液元件、第二移液元件、第一腔和第四腔处于同一移液通道51内，推动第一移液元件或第二移液元件其中之一可以同时实现上述的挤压，在这种情况下，第一移液元件和第二移液元件可以实现逐级联动的状态，例如在第一移液元件被推动的情况下，第一移液元件首先受力移动，挤压第一腔内的样本，第二移液元件移动的阻力可能大于第一腔内液体被移动的阻力，此时第一腔内的样本优先被转移，当第一腔内的样本被排出至第一移液元件对第二移液元件的作用力大于第二移液元件移动的阻力时，第二移液元件开始挤压第四腔内的样本，使得第四腔内的样本也被转移，或者，在另一些可能的情况下，第二移液元件被推动，第二移液元件首先受力移动并挤压第四腔内的样本，此时，第一移液元件移动的阻力可能大于第四腔内液体被移动的阻力，第四腔内的样本优先被转移，当第四腔内的样本被排出至第二移液元件对第一移液元件的作用力大于第一移液元件移动的阻力时，第一移液元件开始挤压第一腔内的样本，使得第一腔内的样本也被转移。在有些情况下，我们希望，当第一移液元件和第二移液元件在如前所述的联动状态下，第一腔内的液体优先被转移，然后第四腔内的液体才冲破检测区域的入口，这是为了确保第一腔内转移到第二腔内的液体样本不会在检测的时候被污染，当然，第一腔和第四腔的转移也可以同步进行，由于在结构上有一个顺着液体流向的顺序，因此回流或者污染的可能性较小。In some preferred manners, the first pipetting element 52 and the first cavity 41 are located in the same pipetting channel 51, and the above-mentioned squeezing can be achieved by pushing the first pipetting element. In some preferred manners, the second pipetting element and the fourth cavity are in the same pipetting channel, and pushing the second pipetting element can realize the above-mentioned squeezing. In some preferred ways, the first pipetting element, the second pipetting element, the first cavity and the fourth cavity are in the same pipetting channel 51, and pushing one of the first pipetting element or the second pipetting element can At the same time, the above-mentioned squeezing is realized. In this case, the first pipetting element and the second pipetting element can realize the state of step-by-step linkage. For example, when the first pipetting element is pushed, the first pipetting element First, it is forced to move and squeeze the sample in the first chamber. The resistance of the second pipetting element to move may be greater than the resistance of the liquid in the first chamber to be moved. At this time, the sample in the first chamber is preferentially transferred. When the sample inside is discharged to the first pipetting element on the second pipetting element, the force of the second pipetting element is greater than the resistance of the second pipetting element to move, the second pipetting element begins to squeeze the sample in the fourth chamber, so that the fourth chamber The sample inside is also transferred, or, in some other possible cases, the second pipetting element is pushed, the second pipetting element is first forced to move and squeeze the sample in the fourth chamber, at this time, the first pipetting element is pushed. The resistance of the liquid element to move may be greater than the resistance of the liquid in the fourth chamber to be moved, and the sample in the fourth chamber is preferentially transferred. When the sample in the fourth chamber is discharged to the second pipetting element, the effect of the first pipetting element When the force is greater than the resistance of the first pipetting element to move, the first pipetting element begins to squeeze the sample in the first chamber, so that the sample in the first chamber is also transferred. In some cases, we hope that when the first pipetting element and the second pipetting element are in the linkage state as described above, the liquid in the first chamber is preferentially transferred, and then the liquid in the fourth chamber breaks through the detection The entrance of the area is to ensure that the liquid sample transferred from the first chamber to the second chamber will not be contaminated during detection. Of course, the transfer of the first chamber and the fourth chamber can also be performed synchronously, due to the structural There is a sequence that follows the flow of the liquid, so there is less chance of backflow or contamination.

在一些优选的方式中，移液通道与第二腔可以实现液体连通或隔断。在一些优选的方式中，移液通道与检测区域可以实现液体连通或隔断。在一些优选的方式中，第一移液元件和第二移液元件将移液通道移液通道分隔为第一腔和第四腔。在一些优选的方式中，第二移液元件将第四腔和第二腔隔断，实际上，从图中也可以看出，在一些优选的方式中，第一腔和第四腔是移液通道上的两段。In some preferred manners, the pipetting channel and the second cavity can achieve liquid communication or isolation. In some preferred manners, the pipetting channel and the detection area can be in liquid communication or isolation. In some preferred manners, the first pipetting element and the second pipetting element divide the pipetting channel into a first cavity and a fourth cavity. In some preferred ways, the second pipetting element separates the fourth cavity from the second cavity. In fact, it can also be seen from the figure that in some preferred ways, the first cavity and the fourth cavity are pipetting Two segments on the channel.

在一些优选的方式中，当第一腔内的样本被转移到第二腔内时，第一腔的体积随之缩小。在一些优选的方式中，当第一腔的体积缩小时，第一移液元件和第二移液元件随之靠拢。在一些优选的方式中，当第四腔内的样本被转移到测试区域内时，第四腔的体积随之缩小。在一些优选的方式中，当第一腔内的液体被转移后，第一腔和第二腔之间的液体连通状态被隔断。在一些优选的方式中，当第四腔内的液体被转移时，第四腔和第三腔之间的液体连通状态被隔断。在一些优选的方式中，第四腔和第三腔的连通状态被隔断是通过第二移液元件在移动过程中封闭第二通道来实现的。In some preferred manners, when the sample in the first chamber is transferred into the second chamber, the volume of the first chamber decreases accordingly. In some preferred manners, when the volume of the first cavity decreases, the first pipetting element and the second pipetting element move closer together. In some preferred manners, when the sample in the fourth chamber is transferred into the testing area, the volume of the fourth chamber decreases accordingly. In some preferred manners, after the liquid in the first cavity is transferred, the liquid communication state between the first cavity and the second cavity is blocked. In some preferred manners, when the liquid in the fourth cavity is transferred, the liquid communication state between the fourth cavity and the third cavity is blocked. In some preferred manners, the communication state of the fourth chamber and the third chamber is blocked by closing the second channel during the movement of the second pipetting element.

本实用新型的另一个特点是，可以实现定量检测。例如，在一些优选的方式中，第四腔的初始体积固定，也就是说，在第四腔受力被压缩之前，第四腔内能够装入的样本的量是可以确定的。在一些优选的方式中，第二移液元件在移液通道内的初始位置固定。在一些优选的方式中，第一腔的初始体积固定，也就是说，在第一腔受力被压缩之前，第一腔内能够装入的样本的量是可以确定的。在一些优选的方式中，第一移液元件在移液通道内的初始位置固定。在一些优选的方式中，第一移液元件和第二移液元件在移液通道内的相对初始位置固定。Another feature of the utility model is that quantitative detection can be realized. For example, in some preferred manners, the initial volume of the fourth cavity is fixed, that is, before the fourth cavity is compressed by force, the amount of sample that can be loaded into the fourth cavity can be determined. In some preferred manners, the initial position of the second pipetting element within the pipetting channel is fixed. In some preferred manners, the initial volume of the first cavity is fixed, that is, before the first cavity is compressed by force, the amount of the sample that can be loaded into the first cavity can be determined. In some preferred manners, the initial position of the first pipetting element within the pipetting channel is fixed. In some preferred manners, the relative initial positions of the first pipetting element and the second pipetting element in the pipetting channel are fixed.

在一些优选的方式中，移液通道具有一个移液开口77，通过移液开口可以向移液通道内施加外力，实现上述的挤压。在一些优选的方式中，移液开口可以被第一移液元件或第二移液元件所密封。在一些优选的方式中，移液元件还包括能够推动第一移液元件和/或第二移液元件的移液塞。在一些优选的方式中，移液塞能够通过移液开口伸入移液通道内。在一些优选的方式中，移液通道的开口被在一些优选的方式中，第一移液元件和/或第二移液元件上设有与移液塞匹配的插口。In some preferred manners, the pipetting channel has a pipetting opening 77 through which an external force can be applied to the pipetting channel to achieve the above-mentioned extrusion. In some preferred ways, the pipetting opening can be sealed by the first pipetting element or the second pipetting element. In some preferred manners, the pipetting element further comprises a pipetting plug capable of pushing the first pipetting element and/or the second pipetting element. In some preferred modes, the pipette plug is capable of extending into the pipetting channel through the pipetting opening. In some preferred ways, the opening of the pipetting channel is defined. In some preferred ways, the first pipetting element and/or the second pipetting element is provided with a socket matching the pipetting plug.

在一些优选的方式中，移液元件和移液通道51之间设有密封元件76，密封元件76可以是如图35所示的密封圈，密封圈可以采用具有一定弹性的材料制成，确保移液元件在移液通道内移动时，不会发生样本从移液元件和移液通道的内壁之间泄露的情况。密封元件76的还有一个作用就是增加移液元件和移液通道内壁之间的摩擦力，在足够的摩擦力作用下，向第一腔和第四腔内的装入液体不足以使移液元件发生位移，就可以实现定量收集和定量检测。In some preferred manners, a sealing element 76 is provided between the pipetting element and the pipetting channel 51. The sealing element 76 may be a sealing ring as shown in FIG. 35, and the sealing ring may be made of a material with certain elasticity to ensure that When the pipetting element moves within the pipetting channel, no leakage of the sample from between the pipetting element and the inner wall of the pipetting channel occurs. Another function of the sealing element 76 is to increase the frictional force between the pipetting element and the inner wall of the pipetting channel. Under the action of sufficient frictional force, the filling of the liquid into the first cavity and the fourth cavity is not enough to make pipetting When the element is displaced, quantitative collection and quantitative detection can be achieved.

如图31-32所示，在一个具体的实施方式中，第一移液元件52包括一个第一移动腔79，动力部件例如移液塞78可以部分伸入这个移动腔79内从而推动第一移液元件52，对应的，移液塞78也可以设置一个锥部，这个腔体可以为动力部件提供施力点，同时还能够一定程度上限定推动的方向。在一些优选的方式中，也可以不设置第一移动腔79。在一些优选的方式中，第一移液元件52上设有支撑脚80，支撑脚80可以隔开第一移液元件52和第二移液元件53，确保两个移液元件之间始终留有一定的空间。在一些优选的方式中，第一移液元件上也可以不设置支撑脚。在一些优选的方式中，第一移液元件上设有密封槽81，密封元件76安装在密封槽81内。密封槽81可以是一道或者多道。As shown in FIGS. 31-32, in a specific embodiment, the first pipetting element 52 includes a first moving cavity 79, and a power component such as a pipette plug 78 can partially extend into the moving cavity 79 to push the first moving cavity 79. Correspondingly, the pipetting element 52 and the pipetting plug 78 can also be provided with a taper, and the cavity can provide a force application point for the power component, and can also limit the pushing direction to a certain extent. In some preferred manners, the first moving cavity 79 may not be provided. In some preferred manners, the first pipetting element 52 is provided with a supporting foot 80, and the supporting foot 80 can separate the first pipetting element 52 and the second pipetting element 53 to ensure that there is always a gap between the two pipetting elements. There is a certain space. In some preferred manners, the first pipetting element may not be provided with support feet. In some preferred manners, a sealing groove 81 is provided on the first pipetting element, and the sealing element 76 is installed in the sealing groove 81 . The sealing groove 81 can be one or more.

如图33-34所示，在一个具体的实施方式中，第二移液元件53包括一个第二移动腔82，动力部件可以部分伸入这个移动腔82内推动第二移液元件53，从而将第四腔内的样本推入到检测区域内，如图29所示是第四腔内的样本被完全推入检测区域的状态。在一些优选的方式中，也可以不设置第二移动腔82。As shown in FIGS. 33-34 , in a specific embodiment, the second pipetting element 53 includes a second moving cavity 82 , and the power component can partially extend into the moving cavity 82 to push the second pipetting element 53 , thereby When the sample in the fourth chamber is pushed into the detection area, as shown in FIG. 29 , the sample in the fourth chamber is completely pushed into the detection area. In some preferred manners, the second moving cavity 82 may not be provided.

收集液体样本的方法Methods of collecting liquid samples

本实用新型提供一种收集液体样本的方法，该方法采用如前所述的样本收集装置，该样本收集装置包括用于收集液体样本的第一腔和用于收集确认检测样本的第二腔，第一腔和第二腔能够处于液体连通或隔断的状态，当第一腔和第二腔处于液体连通状态时，第一腔内的液体能够被转移到第二腔内。The utility model provides a method for collecting liquid samples. The method adopts the aforementioned sample collecting device, the sample collecting device comprises a first cavity for collecting liquid samples and a second cavity for collecting confirmation detection samples, The first cavity and the second cavity can be in a state of liquid communication or isolation, and when the first cavity and the second cavity are in a liquid communication state, the liquid in the first cavity can be transferred into the second cavity.

在一些优选的方式中，还包括用于收集样本的第三腔，第三腔和第一腔能够与第一腔处于液体连通或隔断的状态，可以通过第三腔进行初始样本的收集，第一腔内所收集到的样本，可能会被转移到第二腔内用于二次检测用途。In some preferred manners, it also includes a third chamber for collecting samples, the third chamber and the first chamber can be in a state of liquid communication or isolation with the first chamber, and the initial sample collection can be performed through the third chamber, and the first Samples collected in one chamber may be transferred to the second chamber for secondary testing purposes.

在一些优选的方式中，当第一腔和第三腔处于液体连通状态时，第三腔内收集的液体能够同时进入第一腔，也就是说在第三腔进行样本初始收集的时候，第一腔内同时也能够装入初始收集的样本。In some preferred manners, when the first chamber and the third chamber are in liquid communication state, the liquid collected in the third chamber can enter the first chamber at the same time, that is to say, when the third chamber performs initial sample collection, the A chamber can also hold the initially collected sample.

在一些优选的方式中，当第一腔内的液体被转入第二腔内时，第一腔和第三腔处于液体隔断状态，由于第二腔内的样本是用于二次确认检测，为了确保第二腔内的样本不被污染，在转移之前就将第一腔与其他的腔室进行隔离。In some preferred manners, when the liquid in the first chamber is transferred into the second chamber, the first chamber and the third chamber are in a state of liquid isolation, since the sample in the second chamber is used for secondary confirmation detection, To ensure that the samples in the second chamber are not contaminated, the first chamber is isolated from the other chambers prior to transfer.

在一些优选的方式中，还包括用于收集待检测样本的第四腔，第四腔能够与第三腔处于液体连通或隔断的状态。In some preferred manners, a fourth chamber for collecting samples to be detected is further included, and the fourth chamber can be in a state of liquid communication or isolation with the third chamber.

在一些优选的方式中，当第四腔与第三腔处于液体连通状态时，第三腔内收集的液体能够同时进入第四腔，第四腔也可以与第三腔在初始收集样本的时候就处于连通的状态，这样第四腔也可以和第三腔基本上同步地完成所需要的样本，第四腔内所收集到的样本主要用于初次检测，初次检测可以直接在第四腔内进行，也可以通过第四腔转移到其他区域进行，例如检测区域。In some preferred manners, when the fourth chamber and the third chamber are in liquid communication state, the liquid collected in the third chamber can enter the fourth chamber at the same time, and the fourth chamber can also be connected with the third chamber when the sample is initially collected. It is in a connected state, so that the fourth chamber can also complete the required samples basically synchronously with the third chamber. The samples collected in the fourth chamber are mainly used for the initial detection, and the initial detection can be directly in the fourth chamber. It can also be transferred to other areas through the fourth chamber, such as the detection area.

在一些优选的方式中，还包括检测区域，第四腔能够与检测区域处于液体连通或隔断的状态，当第四腔在初始收集的时候，第四腔与检测区域可以被隔离开来，也就是说，收集和检测可以是相互独立的环节。In some preferred manners, a detection area is also included, and the fourth chamber can be in a state of liquid communication or isolation with the detection area. When the fourth chamber is initially collected, the fourth chamber can be isolated from the detection area, and also That is, collection and detection can be separate links.

在一些优选的方式中，当第四腔与检测区域处于液体连通状态时，第四腔和第三腔处于液体隔断状态，一方面可以确保检测区域不被其他腔室可能造成的污染影响，另一方面可以实现定量检测，只要设定第四腔的体积，就可以实现对进入检测区域的样本的定量。In some preferred ways, when the fourth chamber and the detection area are in liquid communication state, the fourth chamber and the third chamber are in a liquid isolation state, on the one hand, it can ensure that the detection area is not affected by possible contamination caused by other chambers, and on the other hand On the one hand, quantitative detection can be achieved. As long as the volume of the fourth chamber is set, the quantitative detection of the sample entering the detection area can be achieved.

在一些优选的方式中，第二腔和第三腔能够结合或者分离。在一些优选的方式中，第二腔和第一腔能够结合或者分离。由于第二腔是需要从第一腔或者第三腔获取到所收集的样本的，因此第二腔必须和第一腔或者第三腔或者其中之一建立液体连通的关系，当获取到了所需的样本之后，第二腔又必须要能够独立密封并保存其中的腔体，甚至要被独立进行运输，送往二次检测机构，因此第二腔有必须要和第一腔或者第三腔或者其中之一分离，在一些优选的方式中，第二腔可以和第一腔或者第三腔或者其中之一可拆式的结合或者连接。In some preferred ways, the second cavity and the third cavity can be combined or separated. In some preferred ways, the second cavity and the first cavity can be combined or separated. Since the second chamber needs to acquire the collected sample from the first chamber or the third chamber, the second chamber must establish a liquid communication relationship with the first chamber or the third chamber or one of them. After the sample is collected, the second chamber must be able to independently seal and store the chambers in it, and even be transported independently and sent to the secondary detection mechanism, so the second chamber must One of them is separated, and in some preferred manners, the second cavity can be detachably combined or connected with the first cavity or the third cavity or one of them.

在一些优选的方式中，还包括第一腔和第二腔之间的连通装置，连通装置为第一腔内的样本进入到第二腔内提供了一个较为便利的渠道和路径。In some preferred manners, a communication device between the first cavity and the second cavity is also included, and the communication device provides a relatively convenient channel and path for the sample in the first cavity to enter the second cavity.

在一些优选的方式中，在初始收集样本的时候，连通装置并没有安装到位，需要进行二次确认收集的时候，再安装连通装置。In some preferred manners, when the sample is initially collected, the communication device is not installed in place, and the communication device is installed when a secondary confirmation collection is required.

在一些优选的方式中，连通装置可以让第一腔和第二腔处于液体连通的状态也可以将第一腔和第二腔的连通状态隔断。In some preferred manners, the communication device can keep the first cavity and the second cavity in a state of liquid communication, and can also block the communication state of the first cavity and the second cavity.

在一些优选的方式中，连通装置可以将第一腔和第三腔的连通状态隔断。当初始样本的收集完成后，为了确保二次确认样本的无污染，可以先将第一腔和第三腔进行隔断。In some preferred manners, the communication device can block the communication state of the first cavity and the third cavity. When the collection of the initial sample is completed, in order to ensure the non-contamination of the second confirmation sample, the first chamber and the third chamber can be separated first.

在本实用新型中，由于初始收集到的样本无法自然进入到第二腔内，必须要通过一定的外力作用下，在这种情况下，就必须要对初始收集到的样本采取一定的作用力。In the present invention, since the initially collected sample cannot enter the second cavity naturally, it must be acted by a certain external force. In this case, a certain force must be applied to the initially collected sample .

因此，在一些优选的方式中，本实用新型的方法还提供一种移液元件，在初始收集完成后，第一腔内已经有足够量的样本，那么此时推动移液元件，对第一腔内的样本进行挤压，使其直接或者通过连通装置进入到第二腔内，于此同时，第一腔本身的体积被压缩。在一些优选的方式中，移液元件也可以对第四腔内的样本进行转移。在一些优选的方式中，第四腔内样本的转移可以在第一腔内样本转移之后。在一些优选的方式中，第一腔和第四腔可以分别采用不同的移液元件进行挤压。在一些优选的方式中，第一腔和第四腔的移液元件之间可以实现联动。Therefore, in some preferred manners, the method of the present invention also provides a pipetting element. After the initial collection is completed, there is already a sufficient amount of samples in the first chamber, and then the pipetting element is pushed at this time, and the first chamber has a sufficient amount of samples. The sample in the cavity is squeezed into the second cavity directly or through the communication device, and at the same time, the volume of the first cavity itself is compressed. In some preferred manners, the pipetting element can also transfer the sample in the fourth chamber. In some preferred manners, the transfer of the sample in the fourth chamber may follow the transfer of the sample in the first chamber. In some preferred manners, the first cavity and the fourth cavity can be squeezed with different pipetting elements respectively. In some preferred manners, linkage can be achieved between the pipetting elements of the first chamber and the fourth chamber.

在一些优选的方式中，本实用新型的方法还提供移液通道，上述的移液元件能够在移液通道内进行移动，从而对第一腔或第四腔内的液体进行挤压。在一些优选的方式中，第一腔或第四腔可以是移液通道内的某一段，通过不同的移液元件将其分隔开来形成腔体。在一些优选的方式中，第一腔可以和第二腔实现液体连通。在一些优选的方式中，第四腔可以和检测区域实现液体连通。也就是说，作为移液通道本身就可以和第二腔或者检测区域或者二者连通。In some preferred manners, the method of the present invention further provides a pipetting channel, and the above-mentioned pipetting element can move in the pipetting channel, so as to squeeze the liquid in the first cavity or the fourth cavity. In some preferred manners, the first cavity or the fourth cavity may be a certain section in the pipetting channel, which is separated by different pipetting elements to form a cavity. In some preferred manners, the first cavity can be in fluid communication with the second cavity. In some preferred manners, the fourth chamber can be in liquid communication with the detection area. That is to say, the pipetting channel itself can communicate with the second chamber or the detection area or both.

在一些优选的方式中，本实用新型的方法还提供一种移液塞，移液塞主要是用于向移液元件提供移动的动力，使其在移液通道内移动从而对第一腔和/或第四腔内的样本产生挤压的力，使这些样本进行转移。In some preferred manners, the method of the present invention also provides a pipetting plug, which is mainly used to provide moving power to the pipetting element, so that it moves in the pipetting channel so as to affect the first cavity and the /or the samples in the fourth chamber generate a squeezing force to transfer these samples.

在一些优选的方式中，本实用新型的方法还提供移液元件和移液通道之间的密封结构，确保在移液元件受力移动时，其与移液通道的内壁之间不会产生缝隙，不会发生样本泄露。In some preferred manners, the method of the present invention also provides a sealing structure between the pipetting element and the pipetting channel to ensure that when the pipetting element is forced to move, no gap will be created between it and the inner wall of the pipetting channel , no sample leakage will occur.

样本检测方法Sample detection method

本实用新型提供一种检测液体样本中是否存在被分析物质的方法，所述检测方法包括上述的任意一种方式的样本收集装置，通过样本收集装置收集待检测的样本，待第四腔内收集有样本后，对其中的样本进行检测。在一些优选的方式中，待第三腔内收集有样本后，对其中的样本进行检测。在一些优选的方式中，将第四腔内的样本转移到检测区域对其进行检测。在一些优选的方式中，将第三腔内的样本转移到检测区域对其进行检测。等获得检测结果后，让第二腔按照上述任意的方式与样本收集装置进行分离。The utility model provides a method for detecting whether a substance to be analyzed exists in a liquid sample, the detection method includes any one of the above-mentioned sample collection devices, the samples to be detected are collected by the sample collection device, and the samples to be detected are collected in a fourth cavity. After a sample is available, the sample in it is tested. In some preferred manners, after the sample is collected in the third chamber, the sample in the third chamber is detected. In some preferred manners, the sample in the fourth chamber is transferred to the detection area for detection. In some preferred manners, the sample in the third chamber is transferred to the detection area for detection. After the detection results are obtained, the second chamber is separated from the sample collection device in any of the above-mentioned manners.

一个具体的实施例a specific example

如图2所示，本实用新型的样本收集装置可以包括盖体63和第三腔43，盖体和第三腔通过连接部位69可拆式连接。样本收集装置还可以包括一些零部件，这些零部件在使用前可以是单独不装配的状态，例如第二腔42、装配结构62、连通器58、移液塞78等，这些零部件在运输包装时，可以被装入第三腔43内，盖体63的装配通道上，可以预先配置一个塞子，用于塞住装配通道，防止积灰或者装配通道内部被污染。在一些情况下，连通器58也可以作为一个零部件，在使用时再装配到盖体上。使用时，将塞子取下，然后将第二腔42装配到盖体63的装配通道内，第二腔本身可以安装在一个装配结构上，这个装配结构和第二腔形成一个装配体，这个装配体装入到盖体63的装配通道内，然后再将连通器58也装入到装配通道70的下端，连通器58可以将装配通道的下端封闭，在使用前，如图36所示，连通器58并不会刺破第二腔。在一些情况下，连通器58可以是预先装配在盖体62的装配通道底部的，但是并没有装配到配合的极限位置。As shown in FIG. 2 , the sample collection device of the present invention may include a cover body 63 and a third cavity 43 , and the cover body and the third cavity are detachably connected through a connecting portion 69 . The sample collection device may also include components that may be individually disassembled prior to use, such as the second chamber 42, the assembly structure 62, the connector 58, the pipette plug 78, etc., which are packaged in shipping can be installed into the third cavity 43, and a plug can be pre-configured on the assembly channel of the cover body 63 to plug the assembly channel to prevent dust accumulation or contamination inside the assembly channel. In some cases, the connector 58 may also be used as a component that is reassembled to the cover during use. When in use, the plug is removed, and then the second cavity 42 is assembled into the assembly channel of the cover body 63. The second cavity itself can be installed on an assembly structure, and the assembly structure and the second cavity form an assembly body. This assembly The body is installed into the assembly channel of the cover body 63, and then the communication device 58 is also installed into the lower end of the assembly channel 70. The communication device 58 can close the lower end of the assembly channel. Before use, as shown in FIG. The device 58 does not pierce the second cavity. In some cases, the connector 58 may be pre-assembled at the bottom of the assembly channel of the cover body 62, but not assembled to the limit position of the mating.

收集样本时，打开盖体，按照上述关系将第二腔等部件装配到盖体内，然后向第三腔内收集样本，在第三腔内收集样本的同时，样本会自动流入到第一腔和第四腔内，直到达到所需的量，然后将盖体63合上，在盖体密封的过程中，连通器58首先会封闭第一通道，然后盖体继续向下盖合，则装配通道会下压，使连通器进一步进入到装配通道内，直至刺破第二腔上的密封件57，此时第一通道被连通器封闭，第一腔和第三腔处于隔离状态，而第一腔和第二腔通过连通器处于液体连通状态，但是由于连通器是通过针头连接的，第一腔内的液体又是位于第二腔的下方，因此第一腔内的液体不会主动流入第二腔内，第四腔内的样本也不会主动流入检测区域内。When collecting the sample, open the cover, assemble the second cavity and other components into the cover according to the above relationship, and then collect the sample into the third cavity. When the sample is collected in the third cavity, the sample will automatically flow into the first cavity and the second cavity. In the fourth cavity, until the required amount is reached, then close the cover 63. During the sealing process of the cover, the communication device 58 will first close the first channel, and then the cover will continue to cover downward, and the channel will be assembled. will press down, so that the communicating device further enters the assembly channel, until the seal 57 on the second cavity is pierced. At this time, the first channel is closed by the communicating device, the first cavity and the third cavity are in an isolated state, and the first cavity is in an isolated state. The cavity and the second cavity are in a state of liquid communication through the communicating device, but since the communicating device is connected by a needle, and the liquid in the first cavity is located below the second cavity, the liquid in the first cavity will not actively flow into the second cavity. In the second chamber, the sample in the fourth chamber will not actively flow into the detection area.

检测样本时，通过移液塞78向内推动第一移液元件52，此时第一移液元件52向内的移动会使第一腔41的体积变小，挤压第一腔内的液体样本，使其向第二腔移动，同时也会对第二移液元件53产生向内的推力，但是在这个向内的推力克服第二移液元件53与移液通道51内壁之间的摩擦阻力之前，第二移液元件53都是不动的，直到第一移液元件52和第二移液元件53相接触，此时第二腔已基本上完成样本的收集，进一步向内推动移液塞，第二移液元件53开始挤压第四腔内的液体样本，将其推入检测区域内，通过测试元件进行检测，如29所示的状态为第四腔内的样本完全被推入检测区域内。由于第二移液元件51的位置在初始状态下是可以确定的，因此第四腔44的体积是可以确定的，从而实现定量检测。When the sample is detected, the first pipetting element 52 is pushed inward by the pipetting plug 78. At this time, the inward movement of the first pipetting element 52 will reduce the volume of the first chamber 41 and squeeze the liquid in the first chamber. The sample is moved to the second cavity, and at the same time, it will also generate an inward thrust on the second pipetting element 53, but this inward thrust overcomes the friction between the second pipetting element 53 and the inner wall of the pipetting channel 51. Before the resistance, the second pipetting element 53 is immobile until the first pipetting element 52 and the second pipetting element 53 are in contact. At this time, the second chamber has basically completed the collection of the sample, and the pipette is further pushed inward. Liquid plug, the second pipetting element 53 begins to squeeze the liquid sample in the fourth chamber, pushes it into the detection area, and detects through the test element. The state shown in 29 is that the sample in the fourth chamber is completely pushed into the detection area. Since the position of the second pipetting element 51 can be determined in the initial state, the volume of the fourth cavity 44 can be determined, thereby realizing quantitative detection.

在本实施例的方式中，可以在检测区域内放置测试元件，通过测试元件来对样本进行初始检测，检测区域采用透明材料制成，通过检测区域的外表面可以直接观察到测试结果，当测试结果可能呈阳性或者弱阳性或者无法确定的情况下，需要进行二次确认检测时，通过转动旋钮76，将第二腔以及装配结构取出，此时连通器留在检测装置中，第二腔可以独立被运往二次确认检测机构进行检测。In the method of this embodiment, a test element can be placed in the detection area, and the sample can be initially detected by the test element. The detection area is made of transparent material, and the test result can be directly observed through the outer surface of the detection area. In the case that the result may be positive or weakly positive or cannot be determined, when a secondary confirmation test is required, the second cavity and the assembly structure are taken out by turning the knob 76. At this time, the communication device remains in the detection device, and the second cavity can be used. Independently shipped to a secondary confirmation testing agency for testing.

Claims (10)

1. a kind of assembling structure of cavity, characterized in that the connection or combination that assembling structure can be removable with cavity；AssemblyStructure has one convenient for the assembling structure and lid is combined or isolated element.

2. a kind of assembling structure of cavity according to claim 1, characterized in that assembling structure can with other componentTear the connection or combination of formula open.

3. a kind of assembling structure of cavity according to claim 1, characterized in that assembling structure includes outer wall and inner cavity.

4. a kind of assembling structure of cavity according to claim 3, characterized in that cavity can be loaded into inner cavity.

5. a kind of assembling structure of cavity according to claim 4, characterized in that cavity and inner cavity can use fixed knotIt closes, be fixedly connected or the form of the removable connection of removable combination is assembled together.

6. a kind of assembling structure of cavity according to claim 3, characterized in that the outer wall of assembling structure is equipped withEngraved structure.

7. a kind of assembling structure of cavity according to claim 1, characterized in that this element is handle or knob.

8. a kind of assembling structure of cavity according to claim 7, characterized in that assembling structure, which is equipped with, determines ring, fixedRing set is located on cavity, and can be fixedly connected with one end of cavity, in conjunction with or removable connection or combination.

9. a kind of assembling structure of cavity according to claim 8, characterized in that fixed ring is respectively positioned under assembling structureEnd.

10. a kind of assembling structure of cavity according to claim 1, characterized in that it further include the sealing element of cavity, sealingPart is fixed in assembling structure.