Pulse controllable syringe system for insulineThis utility model relates to medical automatic injector.
China's onset diabetes rate is 1%, estimate that diabetics has about 10,000,000 approximately, wherein have half people to need continuously approximately or be interrupted and use insulin, but because of the quality and the injecting method of insulin not good, the use face of insulin dwindles greatly, causes a large amount of patients to be disabled or death.The progress key of injection of insulin method, one is low dose of successive administration, two are to simulate human insulin β cells physiological insulin secretion curve.Continuous injection all gives attention highly to insulin in the world.As Japanese CSII system (Continuous Subcutaneous Insuline Injection System) and Clossed System, adopt blood glucose to detect in real time, by the computer realization closed loop control, make the insulin administration amount adapt to the changes of blood glucose situation at any time.But this system is too complicated and expensive, is not easy to large-scale popularization and uses.The adjustable automatic injector of YZD-I of domestic Zhenjiang development supplies Teat pipette by micro motor for driving, and scalable administration injection frequency, but all can not adapt to the requirement that insulin is injected low dose continuously for dose and control accuracy, single injection dosage is more than ten times of cushion still, adjust the requirement of dosage in the time of particularly can not simulating physiology insulin secretion curve and dining.
The purpose of this utility model provide a kind of can the continuous small dose administration, and can simulate human insulin β cells physiological insulin secretion curve and adjust the controlled insulin-injecting system of pulse of the requirement of dosage when having meal.This system bulk is little, is easy to carry.
Main points of the present utility model are to adopt pulse control circuit, the control electromagnetic actuator is squeezed grug transportation tube, and utilize two check-valves to make the medicinal liquid one-way flow, electric pulse of the every acceptance of electromagnetic actuator just provides a fixed small dose, and automatic control circuit can provide electric impulse signal according to program and the Automatic Frequency set.Artificial pressing dining button during dining, control circuit promptly converts " the dining frequency " of setting to, and (for example 20 minutes) control circuit restores automatically after after a while, returns to the frequency maintenance dose of former setting.For preventing instrument failure and patient carelessness, control circuit is provided with acousto-optic work indication and reports to the police.The additional dosage of having meal can be set up by doctor's advice.
Fig. 1 is the controlled insulin-injecting system automatic control circuit of a pulse schematic diagram.Fig. 2 is the controlled insulin-injecting system structural representation of pulse.Square frame 1-vibration, frequency divider among Fig. 1, the 2-pulse-width controller, the 3-trigger, the 4-agitator, the 5-pulse width modulation, the 6-power amplifier, 7-sound, light work indication, 8-has meal and adds the dose starting button, and the additional dose of 9-dining is regulated.11-automatic control circuit among Fig. 2,12-lead, 13-electromagnetic actuator, 14-drug storage bottle, 15-insulin, 16-latex tubing, 17, the 18-check-valves, 19-syringe needle.
The controlled insulin-injecting system of contrast accompanying drawing paired pulses further specifies below.Vibration, frequency divider 1 produce a built-in oscillation frequency, and carry out frequency division make it to produce be fit to insulin continuously injection the interval and have meal preset time.Agitator 4, trigger 3 are need increase administration frequency for solving when having meal, and 8 are the additional administration starting button of having meal.Pulse-width controller 2 is with pulse width modulation 5 restrictions and set pulse width, amplify rear drive electromagnetic actuator 13 by power amplifier 6, sound,light work indication 7 are for safety monitoring and warning, notice to cause the patient whether instrument work normally prevents from fault or have a dinner to forget and press the dining button.After pulse frequency and treatment sequence setting,automatic control circuit 11 is by given frequency and program output electric pulse, and each pulse is oppressed newborn vascular 16 by driving electromagnetic actuator 13 adhesives once during the electromagnetic valve adhesive, a certain amount of medicinal liquid is forced out pipeline, and 19 injection patients are subcutaneous by syringe needle.Pair ofcheck valves 17,18 can only flow medicinal liquid by the direction of arrow of setting, make the medicinal liquid one-way flow can utilize the thin latex tubing of garden type (or the end has sphere), in end spherical cut or pipe side cutout, form unidirectional non-return effect by pipe inside and outside wall liquid body pressure, use in pairs and form continuously injecting systems automatically.The vacuum that medicinal liquid 15 forms when discharging by electromagnetic valve is replenished automatically from drug storage bottle 14.Syringe needle 19 is embedded in the subcutaneous of patient's arm, forms full-automatic continuous subcutaneous injection.Artificial pressing dining button can be accelerated administration frequency by set-point during dining, the needs of meal island element when having meal to adapt to.
Pulse controllable syringe system for insuline has significant advantage: miniature, be easy to carry, be worn on wrist such as wrist-watch; Energy-conservation, the miniature rechargeable battery of 3.8V, charging in 7-10 days is once; Convenient, full-automatic continuous subcutaneous injection can simulate physiological amount and release profiles; Effective, the low dose of continuous release of insulin makes it subcutaneous abundant

Overflow, result for the treatment of is better than heavy dose of fractional injection, and has greatly dwindled the use amount of insulin, has avoided the reaction of medicine source and the complication such as hypoglycemia Somegy reaction and kidney damage. Pulse controllable syringe system for insuline adapts to the injection for curing of various disease conditions, I type (IDDM) diabetes for example, severe II type (NIDDM) diabetes, delay into the type diabetes, the type II diabetes of serious complication is arranged, gestational diabetes mellitus, Diabetic Pregnancy, dystrophic diabetes etc. Thereby pulse controllable syringe system for insuline is a kind of of many uses, wears conveniently the therapeutic equipments of safe and reliable science.