技术领域technical field
本实用新型具体涉及一种常压低氧舱，属于动物实验装置技术领域。The utility model specifically relates to a normal-pressure hypoxic chamber, which belongs to the technical field of animal experiment devices.
背景技术Background technique
科学研究发现，多种原因可导致机体处于不同的缺氧状态，使机体的缺氧耐受力下降，缺氧环境下可影响机体的各种代谢，特别是能代谢中的氧化功能作用，可导致机体重要脏器心、脑等组织供氧不足而引起死亡，是严重危害人类健康的因素之一，如何提高缺氧耐受力，改善缺氧状态是目前的研究热点；基于实验需要，设计了常压缺氧损伤模型实验装置，可复制大鼠、小鼠等动物的常压缺氧损伤模型，可用于观察药物的疗效，探讨常压缺氧的机制等。Scientific research has found that a variety of reasons can cause the body to be in different hypoxic states, reducing the body's hypoxia tolerance. Hypoxic environments can affect various metabolisms of the body, especially the oxidation function in energy metabolism. It is one of the factors that seriously endanger human health, which leads to death due to insufficient oxygen supply to important organs such as the heart and brain. How to improve the hypoxia tolerance and improve the hypoxia state is a current research hotspot; based on the experimental needs, the design The normal pressure hypoxia injury model experimental device has been established, which can replicate the normal pressure hypoxia injury model of rats, mice and other animals, and can be used to observe the curative effect of drugs and explore the mechanism of normal pressure hypoxia, etc.
在现有的低氧舱装置中，中国实用新型专利CN201220164989，公开了一种常压低氧舱装置，解决了实验过程中保持氧气浓度稳定的问题，但是这种设备依赖于电路控制系统实现，不仅成本较高，而且操作过程比较复杂。Among the existing hypoxic chamber devices, the Chinese utility model patent CN201220164989 discloses a hypoxic chamber device at atmospheric pressure, which solves the problem of keeping the oxygen concentration stable during the experiment, but this device relies on the circuit control system to realize, Not only the cost is higher, but also the operation process is more complicated.
对于实验人员而言，更倾向于自制常压低氧舱装置。如中国实用新型专利CN201020301569，公开了一种小动物常压低氧实验舱，这种装置虽然结构简单，但是不适合于同时对多个动物进行实验，并且氧气的浓度控制和监测能力不强，很难保证实验的顺利进行。For experimenters, they are more inclined to make their own atmospheric pressure hypoxic chamber devices. For example, the Chinese utility model patent CN201020301569 discloses a small animal atmospheric hypoxia experimental cabin. Although this device has a simple structure, it is not suitable for conducting experiments on multiple animals at the same time, and the oxygen concentration control and monitoring capabilities are not strong. It is difficult to guarantee the smooth progress of the experiment.
实用新型内容Utility model content
因此，本实用新型的目的是提供一种适用于多个动物同时进行实验，具有很好的气体浓度控制可监测能力，结构简单的常压低氧舱。Therefore, the purpose of this utility model is to provide a kind of atmospheric pressure hypoxic chamber that is applicable to a plurality of animals to carry out experiment at the same time, has good gas concentration control and monitoring ability, and simple structure.
具体的，本实用新型的常压低氧舱，包括1个以上的动物舱，所述常压低氧舱还包括气瓶、流量控制装置、氧气浓度检测仪、进气管路、出气管路，所述动物舱包括舱体、舱盖、喂水孔、进气孔、出气孔，喂水孔、进气孔、出气孔设置在舱体上，舱体内设有1个以上的不锈钢隔板，所述流量控制装置包括玻璃箱、气体流量计，气体流量计固定安装在玻璃箱的不锈钢框架上，所述气体流量计数量与动物舱数量一致，所述进气管路一端通过第一阀门连接气瓶，所述进气管路另一端通过第二阀门连接气体流量计进口，所述出气管路将气体流量计出口与动物舱进气孔逐一对接，所述氧气浓度检测仪连接在出气孔位置。Specifically, the normal-pressure hypoxic cabin of the present invention includes more than one animal cabin, and the normal-pressure hypoxic cabin also includes a gas cylinder, a flow control device, an oxygen concentration detector, an air inlet pipeline, and an air outlet pipeline, The animal cabin includes a cabin body, a hatch cover, a water feeding hole, an air inlet hole, and an air outlet hole, and the water feeding hole, the air inlet hole, and the air outlet hole are arranged on the cabin body, and more than one stainless steel partition is arranged in the cabin body, The flow control device includes a glass box and a gas flowmeter. The gas flowmeter is fixedly installed on the stainless steel frame of the glass box. The number of the gas flowmeters is consistent with the number of the animal cabins. bottle, the other end of the air inlet pipeline is connected to the inlet of the gas flowmeter through the second valve, the outlet pipeline connects the outlet of the gas flowmeter with the inlet holes of the animal cabin one by one, and the oxygen concentration detector is connected to the air outlet.
进一步的，所述气瓶包括氧气瓶及氮气瓶，所述动物舱及气体流量计均为3个。Further, the gas cylinders include oxygen cylinders and nitrogen cylinders, and there are three animal cabins and gas flow meters each.
相应的，所述第一阀门为三通阀，所述第二阀门为四通阀，进气管路与第一阀门及第二阀门之间、气体流量计与进气管路及出气管路之间均通过快速接头连接。Correspondingly, the first valve is a three-way valve, and the second valve is a four-way valve. Both are connected by quick connectors.
进一步的，所述动物舱尺寸为长50厘米，宽30厘米，高20厘米。Further, the size of the animal cabin is 50 cm in length, 30 cm in width and 20 cm in height.
进一步的，所述动物舱尺寸为长20厘米，宽20厘米，高15厘米。Further, the size of the animal cabin is 20 cm in length, 20 cm in width and 15 cm in height.
进一步的，所述氧气浓度检测仪为恒定电位电解式检测仪，所述气体流量计为玻璃转子气体流量计。Further, the oxygen concentration detector is a constant potential electrolytic detector, and the gas flowmeter is a glass rotor gas flowmeter.
本实用新型的有益效果在于：本实用新型的常压低氧舱，结构简单，操作简便，动物种类、只数，气体种类、浓度可选择空间大，气体浓度控制准确，实验过程便于观察。适合于动物常压缺氧损伤模型实验使用。The beneficial effects of the utility model are: the normal-pressure hypoxic chamber of the utility model has simple structure, easy operation, large space for selection of animal species, number, gas species and concentration, accurate gas concentration control, and convenient observation of the experimental process. Suitable for animal normal pressure hypoxic injury model experiments.
附图说明Description of drawings
图1为本实用新型的一种常压低氧舱的整体结构示意图；Fig. 1 is the overall structure schematic diagram of a kind of normal pressure hypoxic chamber of the present utility model;
图2为图1中流量控制装置的结构示意图；Fig. 2 is the structural representation of the flow control device in Fig. 1;
图3为图2的后视图；Fig. 3 is the back view of Fig. 2;
图4为图1中动物舱的结构示意图。Fig. 4 is a schematic structural diagram of the animal cabin in Fig. 1 .
附图标记如下：1、动物舱，2、气瓶，3、氧气浓度检测仪，4、进气管路，5、出气管路，6、舱体，7、舱盖，8、喂水孔，9、进气孔，10、出气孔，11、不锈钢隔板，12、玻璃箱，13、气体流量计，14、第一阀门，15、第二阀门。Reference signs are as follows: 1, animal cabin, 2, gas cylinder, 3, oxygen concentration detector, 4, air intake pipeline, 5, air outlet pipeline, 6, cabin body, 7, hatch cover, 8, water feeding hole, 9, air intake hole, 10, air outlet hole, 11, stainless steel clapboard, 12, glass box, 13, gas flow meter, 14, first valve, 15, second valve.
具体实施方式Detailed ways
下面结合附图对本实用新型的具体实施方式进行说明：The specific embodiment of the utility model is described below in conjunction with accompanying drawing:
如图1、图2、图3、图4所示，一种常压低氧舱，包括1个以上的动物舱1，常压低氧舱还包括气瓶2、流量控制装置、氧气浓度检测仪3、进气管路4、出气管路5，动物舱1包括舱体6、舱盖7、喂水孔8、进气孔9、出气孔10，喂水孔8、进气孔9、出气孔10设置在舱体6上，舱体6内设有1个以上的不锈钢隔板11，流量控制装置包括玻璃箱12、气体流量计13，气体流量计13固定安装在在玻璃箱12的不锈钢框架上，气体流量计13数量与动物舱1数量一致，进气管路4一端通过第一阀门14连接气瓶2，进气管路4另一端通过第二阀门15连接气体流量计13进口，出气管路5将气体流量计13出口与动物舱1的进气孔9逐一对接，氧气浓度检测仪3连接在出气孔10位置。As shown in Figure 1, Figure 2, Figure 3, and Figure 4, a normal-pressure hypoxic cabin includes more than one animal cabin 1, and the normal-pressure hypoxic cabin also includes a gas cylinder 2, a flow control device, and an oxygen concentration detection Instrument 3, air intake pipeline 4, air outlet pipeline 5, animal cabin 1 includes cabin body 6, hatch cover 7, water feeding hole 8, air inlet hole 9, air outlet hole 10, water feeding hole 8, air inlet hole 9, outlet The air hole 10 is arranged on the cabin body 6, and more than one stainless steel partition 11 is arranged in the cabin body 6. The flow control device includes a glass box 12 and a gas flowmeter 13. On the frame, the number of gas flowmeters 13 is consistent with the number of animal cabins 1, one end of the air inlet pipeline 4 is connected to the gas cylinder 2 through the first valve 14, and the other end of the air inlet pipeline 4 is connected to the inlet of the gas flowmeter 13 through the second valve 15, and the air outlet pipe The road 5 connects the outlet of the gas flow meter 13 with the air inlet 9 of the animal cabin 1 one by one, and the oxygen concentration detector 3 is connected to the air outlet 10 .
本装置可根据动物的只数、种类调整动物仓1的大小；气体流量控制装置主要是通过调节和各气体连接的气体流量计13来调整动物舱1内气体的浓度；气瓶2根据实验所需可连接不同气体，可选择单一气体，如氧气、氮气、二氧化碳等，亦可选择混合气体，如氧气和氮气混合、氧气和二氧化碳混合，或氧气、氮气、二氧化碳混合等。通过氧气浓度测试仪3监测动物舱1内氧浓度的变化。The device can adjust the size of the animal cabin 1 according to the number and types of animals; the gas flow control device mainly adjusts the concentration of the gas in the animal cabin 1 by adjusting the gas flow meter 13 connected with each gas; Need to be able to connect different gases, you can choose a single gas, such as oxygen, nitrogen, carbon dioxide, etc., or a mixed gas, such as a mixture of oxygen and nitrogen, a mixture of oxygen and carbon dioxide, or a mixture of oxygen, nitrogen, and carbon dioxide. The change of the oxygen concentration in the animal cabin 1 is monitored by an oxygen concentration tester 3 .
优选的，气瓶2包括氧气瓶及氮气瓶，动物舱1及气体流量计13均为3个。Preferably, the gas cylinders 2 include oxygen cylinders and nitrogen cylinders, and there are three animal cabins 1 and gas flow meters 13 each.
相应的，第一阀门14为三通阀，第二阀门15为四通阀，进气管路4与第一阀门14及第二阀门15之间、气体流量计13与进气管路4及出气管路5之间均通过快速接头连接。Correspondingly, the first valve 14 is a three-way valve, and the second valve 15 is a four-way valve. All roads 5 are connected by quick connectors.
作为大鼠实验装置，动物舱1尺寸为长50厘米，宽30厘米，高20厘米。As a rat experimental device, the size of the animal cabin 1 is 50 cm in length, 30 cm in width and 20 cm in height.
作为小鼠实验装置，动物舱1尺寸为长20厘米，宽20厘米，高15厘米。As an experimental device for mice, the size of the animal cabin 1 is 20 cm in length, 20 cm in width and 15 cm in height.
在本实施例中，动物舱1也为玻璃制成，便于观查，氧气浓度检测仪3为恒定电位电解式检测仪，气体流量计13为玻璃转子气体流量计。In this embodiment, the animal cabin 1 is also made of glass for easy observation, the oxygen concentration detector 3 is a constant potential electrolytic detector, and the gas flowmeter 13 is a glass rotor gas flowmeter.
本新型的常压低氧舱操作流程如下：The operating procedure of the new normal-pressure hypoxic chamber is as follows:
首次使用时向动物舱1内加入垫料，后期垫料更换推荐三天一次；Add bedding to the animal cabin 1 when it is used for the first time, and it is recommended to replace the bedding once every three days in the later stage;
将受试验动物按照实验分组放入相应的动物舱1内，并对舱盖7处进行密封；Put the tested animals into the corresponding animal cabin 1 according to the experimental group, and seal the hatch 7;
打开气瓶2阀门，将气体进行混合；Open the gas cylinder 2 valve to mix the gas;
调整玻璃转子气体流量计13，将流量调整至实验所需的大小；Adjust the glass rotor gas flow meter 13 to adjust the flow to the required size of the experiment;
利用氧气浓度检测仪3，对动物仓1内氧气浓度进行检测，如不符合要求，通过气瓶2阀门进行调节；Use the oxygen concentration detector 3 to detect the oxygen concentration in the animal cabin 1, if it does not meet the requirements, adjust it through the valve of the gas cylinder 2;
实验过程中需要对受试验动物定期观察，随时调整气体浓度，保证动物的存活；During the experiment, it is necessary to regularly observe the tested animals and adjust the gas concentration at any time to ensure the survival of the animals;
实验完成后，受试验动物出舱，关闭气瓶2阀门。After the experiment is completed, the tested animals leave the cabin, and the gas cylinder 2 valve is closed.
以上所述是本实用新型的优选实施方式，应当指出，对于本技术领域的普通技术人员来说，在不脱离本实用新型所述原理的前提下，还可以作出若干改进和润饰，这些改进和润饰也应视为本实用新型的保护范围。The foregoing is a preferred embodiment of the present utility model, and it should be pointed out that for those of ordinary skill in the art, some improvements and modifications can be made without departing from the principle of the present utility model. Retouching should also be regarded as the scope of protection of the present utility model.
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720143102.8UCN207855818U (en) | 2017-02-17 | 2017-02-17 | A kind of atmospheric pressure hypoxic chamber |
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720143102.8UCN207855818U (en) | 2017-02-17 | 2017-02-17 | A kind of atmospheric pressure hypoxic chamber |
| Publication Number | Publication Date |
|---|---|
| CN207855818Utrue CN207855818U (en) | 2018-09-14 |
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201720143102.8UExpired - Fee RelatedCN207855818U (en) | 2017-02-17 | 2017-02-17 | A kind of atmospheric pressure hypoxic chamber |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110101482A (en)* | 2019-05-08 | 2019-08-09 | 温州医科大学 | Controllable flow toy journey hypoxemia parallel type experimental provision in short-term |
| CN115428738A (en)* | 2022-08-31 | 2022-12-06 | 上海索伦托医疗科技有限公司 | Animal thermal effect experimental device |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110101482A (en)* | 2019-05-08 | 2019-08-09 | 温州医科大学 | Controllable flow toy journey hypoxemia parallel type experimental provision in short-term |
| CN115428738A (en)* | 2022-08-31 | 2022-12-06 | 上海索伦托医疗科技有限公司 | Animal thermal effect experimental device |
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