Utility model content
The purpose of this utility model is to provide a kind of minimally invasive micro Mutiple Targets note of intracerebral for stereotaxis navigation equipmentSystem is penetrated, to overcome the shortcomings of in currently available technology.
To realize above-mentioned technical purpose, what the technical solution of the utility model was realized in：
A kind of minimally invasive micro Mutiple Targets injecting systems of intracerebral for stereotaxis navigation equipment, including nook closing member and be arrangedIn the overcoat needle tubing on nook closing member, the front end of the overcoat needle tubing is provided with injection needle head end sheath, the rear end insertion of overcoat needle tubingThere is connector, the connector rear end is connected with metal connecting piece, the front end of the nook closing member and the part of overcoat needle tubing jointRounded blunt nosed, the rear end of nook closing member, which is connected with handpiece, the metal connecting piece, is equipped with rotatable transparent carrier liquid Guan LianFitting, the rear end of the transparent carrier liquid pipe connections is connected with the connector being connected with micro-injection pump by transparent carrier liquid pipe.
Further, the length of the overcoat needle tubing is 50-300mm, and external diameter is 1mm, and the pipe thickness of overcoat needle tubing is0.25mm。
Further, the length of the overcoat needle tubing is 198mm.
Further, the length of the nook closing member is 62-312mm, a diameter of 0.4mm.
Further, the length of the nook closing member is 210mm.
Further, the metal connecting piece includes leading section, the rearward end being connected with leading section and connected with rearward endThe block plate connect, the length of the leading section is that external screw thread is provided with 7mm, leading section, and the length of the rearward end is 9mm, instituteThe thickness for stating block plate is 2mm.
Further, the injection needle head end sheath is included in conical head and the afterbody being connected with head, instituteThe length for stating head is 10mm, and the length of the afterbody is 8mm.
Further, graduation mark is provided with the transparent carrier liquid pipe, the length of transparent carrier liquid pipe is 1000-3000mm.
Further, the internal thread matched with external screw thread is provided with the connector, the length of connector is 15mm.
The beneficial effects of the utility model：Directly reduce the contact area of injection needle and brain tissue, and with high rigidity andIt is straight to reduce or eliminate the cutting damage caused during rotation inserting needle to brain tissue.In puncture process, the blunt injection needle head end of circleCerebral blood vessel can effectively be pushed open, reduction even avoids the generation of intracerebral hematoma, and minimum injection injection volume can reach 5ul, veryThe good intracerebral occupation time process for controlling medicine, passes through the transparent graduated PVC carrier fluids pipe of mark, it is ensured that injectionThe visuality and controllability of process.Minimally invasive design so that it is same enter cranium point multi-angle puncture be referred to as may, can carry outMutiple Targets stereotactic injection.To sum up the utility model has the advantages that minimally invasive, micro, visual controllable, Mutiple Targets stereotactic injection.
Brief description of the drawings
, below will be to embodiment in order to illustrate more clearly of the utility model embodiment or technical scheme of the prior artIn required for the accompanying drawing that uses be briefly described, it should be apparent that, drawings in the following description are only of the present utility modelSome embodiments, for those of ordinary skill in the art, on the premise of not paying creative work, can also be according to thisA little accompanying drawings obtain other accompanying drawings.
Fig. 1 is the minimally invasive micro many targets of the intracerebral for stereotaxis navigation equipment according to the utility model embodimentThe structural representation of point injecting systems；
Fig. 2 is the overall structure diagram of the overcoat needle tubing according to the utility model embodiment；
Fig. 3 is the partial enlarged drawing at A in Fig. 2；
Fig. 4 is the structural representation of the nook closing member according to the utility model embodiment；
Fig. 5 is the structural representation of the metal connecting piece according to the utility model embodiment；
Fig. 6 is the structural representation of the stereotaxis navigation equipment fixture according to the utility model embodiment；
Fig. 7 is Fig. 6 top views；
Fig. 8 is Fig. 7 sectional view.
In figure：
1st, overcoat needle tubing；2nd, nook closing member；3rd, metal connecting piece；4th, injection needle head end sheath；5th, connector；6th, transparent carrier liquid pipeConnector；7th, transparent carrier liquid pipe；8th, stereotaxis navigation equipment fixture；9th, handpiece；10th, connector；31st, leading section；32、Rearward end；33rd, block plate；81st, centre bore.
Embodiment
Below in conjunction with the accompanying drawing in the utility model embodiment, the technical scheme in the utility model embodiment is carried outClearly and completely describe, it is clear that described embodiment is only a part of embodiment of the utility model, rather than wholeEmbodiment.Based on the embodiment in the utility model, all other embodiment that those of ordinary skill in the art are obtained all belongs toThe scope protected in the utility model.
As shown in figures 1-8, a kind of intracerebral for stereotaxis navigation equipment according to the utility model embodimentMinimally invasive micro Mutiple Targets injecting systems, including nook closing member 2 and the overcoat needle tubing 1 that is sheathed on nook closing member 2, the overcoat needle tubing 1Front end is provided with injection needle head end sheath 4, and the rear end of overcoat needle tubing 1 is inserted with connector 10, the rear end of connector 10 connectionThere is metal connecting piece 3, the part of the front end and the joint of overcoat needle tubing 1 of the nook closing member 2 is rounded blunt nosed, the rear end of nook closing member 2 connectsIt is connected in handpiece 9, the metal connecting piece 3 and is equipped with rotatable transparent carrier liquid pipe connections 6, is harder rubber systemProduct, it is inserted in metal connecting piece 3, by the foward dome of metal connecting piece 3 and rear baffle, by metal connecting piece 3 and transparentCarrier fluid pipe connections 6 are linked together, and metal connecting piece 3 can be rotated, and can not be separated on the two position, the transparent carrier liquid pipeThe rear end of connector 6 is connected with the connector 5 being connected with micro-injection pump by transparent carrier liquid pipe 7.
The length of the overcoat needle tubing 1 is 50-300mm, and external diameter is 1mm, and the pipe thickness of overcoat needle tubing 1 is 0.25mm.It is preferred that, the length of the overcoat needle tubing 1 is 198mm.
The length of the nook closing member 2 is 62-312mm, a diameter of 0.4mm.It is preferred that, the length of the nook closing member 2 is 210mm.
The metal connecting piece 3 includes leading section 31, the rearward end 32 being connected with leading section 31 and connected with rearward end 32The block plate 33 connect, the length of the leading section 31 is to be provided with external screw thread, the length of the rearward end 32 on 7mm, leading section 31For 9mm, the thickness of the block plate 33 is 2mm.
The injection needle head end sheath 4 is included in conical head and the afterbody being connected with head, the headLength is 10mm, and tip is sharp, can puncture endocranium, the length of the afterbody is 8mm.
Graduation mark is provided with the transparent carrier liquid pipe 7, the length of transparent carrier liquid pipe 7 is 1000-3000mm.
The internal thread matched with external screw thread is provided with the connector 10, the length of connector is 15mm.
Above-mentioned technical proposal of the present utility model is understood for convenience, below by way of new to this practicality in specifically used modeThe above-mentioned technical proposal of type is described in detail.
Using the present apparatus, it is necessary in advance using having extracted the common disposable sterilized injection of 3-5ml physiological saline in advanceDevice is rinsed, and keeps being full of physiological saline in tube chamber, after connector 5 is connected to micro-injection pump；
After the integral device pumpback 5ul air that will be filled with physiological saline, the medicine or cell suspension of requirement can be carried outLoading, the equipment of medicine or cell suspension will be loaded by metal connecting piece 3 by the stabilization of transparent carrier liquid pipe connections 6, watertightThe tail end for being fixed on overcoat needle tubing 1 of envelope.
Operation consent carries out 3DMR scannings to big animal or human central nervous system, and application software carries out preoperative plan targetThe setting of point, and be designed into the bore position of cranium point, or spinal cord target position；
After conventional big animal or human body, anesthesia, position support, installation stereotaxis navigation equipment, according to it is preoperative plan intoRow sphenotresia or spinal lamina are opened；
It is installed to the safety of stereotaxis navigation equipment fixture 8 is firm after stereotaxis navigation equipment, nook closing member 2 is insertedEnter in overcoat needle tubing 1, after overcoat needle tubing 1 and the stable connection of nook closing member 2, check that the head end combined both it should be seamless circle bluntState, stereotaxis navigation equipment fixture 8 is slow transitted through by overcoat needle tubing 1 and the combination of nook closing member 2；
Wherein, injection needle is inserted single or consolidated up and down in 2 fixtures by stereotaxis navigation equipment fixture 8Fixed, the internal diameter of centre bore 81 of stereotaxis navigation equipment fixture 8 is 1+（0.1 mm -0.2mm）, meet Leksell solids fixedTo the fixture of frame, designed in ladder sample, each ladder height is 10mm, and the 1st ladder designs for rectangle, it is convenient to determine baseLine, the 2nd ladder external diameter meets orientation folder clamping internal diameter；
Before endocranium and endorchis is touched, injection needle head end sheath 4 is attached to the knot of overcoat needle tubing 1 and nook closing member 2Fit front end, continuation slowly wears out endocranium or endorchis using the sharpening forward ends of injection needle head end sheath 4 forward；
After endocranium or endorchis is penetrated, appropriate rollback overcoat needle tubing 1, nook closing member 2 and injection needle head end sheath 4 are combinedBody, removes injection needle head end sheath 4, continues slow rotary sleeve needle tubing 1 and the combination of nook closing member 2, through the endocranium perforatedOr endorchis, insert in brain tissue or spinal cord, whole inserting needle process should be stabilization, without vibrating state.
Wherein, metal connecting piece 3, injection needle head end sheath 4, connector 5, transparent carrier liquid pipe connections 6 and transparent carrier liquid7 five parts of pipe are mounted entirety, and forward metal connector 3 is placed on outside transparent carrier liquid pipe connections 6, and the two relative can turnIt is dynamic, can be by the stabilization of transparent carrier liquid pipe connections 6, the tail end for being fixed on overcoat needle tubing 1 of water-stop by metal connecting piece 3；ThoroughlyThe bright rear water-stop connection transparent carrier liquid pipe 7 of carrier fluid pipe connections 6, the rear end of transparent carrier liquid pipe 7 is connected with connector 5, connector 5Continue to connect micro-injection pump.
According to the demand of injection, each target spot ＞ 5ul micro-injection is carried out, the injection scope for recommending each target spot is 5-40ul；After the completion of an injection target spot, it can realize that the straight line in single needle road is more by changing depth of the overcoat needle tubing 1 in intracerebralTarget spot is injected；And realize that 3-D Multi-Target point is injected by changing needle track, the needle track quantity of recommendation is 1-5.
The utility model in order to reach it is minimally invasive, reduce puncture path Accessory injury purpose：1）It is required that the diameter of injection needle compared withSmall, its diameter range is 1-2 millimeters, and this design can reduce the contact area of injection needle and brain tissue；2）It is higher using hardnessStainless steel ensures that the rigidity of injection needle, with straight, when being so rotated into pin in brain parenchym, can be reduced or eliminated as far as possibleThe brain tissue incised injury caused by the bending of injection needle；3）The head end of injection needle need to justify blunt, can push head end in puncture process openThe cerebral blood vessel of contact.In order to reduce the occupation time process in the brain parenchym that injection volume is brought, less needle internal diameter is designed,Scope promotes decoction at 0.2-0.8 millimeter, and using micro-injection pump, and the fixing fabric structure injected every time is in 5-50ul.Because onThe expedients stated, perform the operation and the Accessory injury of brain tissue will be controlled greatly, it is same enter cranium point, carry out multi-angle brain deepPortion is punctured, and combines the depth that adjustment is punctured, and realizes that 3-D Multi-Target point is injected.Injection needle rear end connects transparent PVC pipeline, pipelineUpper reference mark and numeral, in the process real time drug liquid mobility status of injection.
The utility model can realize common drug and biological agent（Including NSC etc.）Focus in brain parenchymUpper or perilesional direct injection.Existing a variety of stereotaxis navigation frame apparatus are relied on, accurately brain can be achieved realTarget spot is injected in matter.For injection therapeutic medicine in brain parenchym, it is necessary to ensure the surgical procedure of injection therapeutic medicine to brain parenchymProduce minimum Accessory injury.These Accessory injuries include：1）Puncture path is damaged（Damage and puncture including the Direct perforantes to brain parenchymGastrointestinal hemorrhage）With 2）The occupation time process in brain parenchym that the injection volume of injection point is brought.Injection medicine in Mutiple Targets brain parenchym, canThe directly region of increase medicine covering, and on the premise of drug concentration is certain, increases drug dose.Compared with the injection of single target spotCompared with its medication effect will significantly, with more Clinical practicability.Medicine is needed in the bolus infusion processes into brain parenchymThe unobstructed of injection needle is determined by visual path.
Preferred embodiment of the present utility model is the foregoing is only, it is all at this not to limit the utility modelWithin the spirit and principle of utility model, any modification, equivalent substitution and improvements made etc. should be included in the utility modelProtection domain within.