CN204989129U - Online electrometric titration system of totally -enclosed formula - Google Patents

Abstract

The utility model discloses an online electrometric titration system of totally -enclosed formula, it includes: the sample is processing unit, quantitative unit, titration unit and washing unit in advance, and sample processing unit in advance includes sampling device, preliminary treatment cup, and the preliminary treatment cup links to each other with sampling device's first liquid outlet, the ration unit includes quantitative sampling device, second peristaltic pump, and quantitative sampling device links to each other with the second liquid outlet of preliminary treatment cup, titrate the unit including titrating cup, titration outfit to titrate the cup and link to each other with quantitative unit through the fourth inlet, titrate the cup and link to each other with the titration outfit through the 5th inlet, it is continuous with the 5th inlet of titrating the cup that the titration outfit passes through the buret, washing unit includes lotion export and valve, and lotion export and sample processing unit's third inlet in advance link to each other, the valve sets up at washing unit and sample in advance between the processing unit. Utilize this system can eliminate the loss that the in -process is titrated in preliminary treatment and sample to the sample, whole titration system is in the totally -enclosed environment.

Description

The online potentiometric titration system of total closed type

Technical field

The utility model belongs to pharmacy or chemical analysis field of experiment equipment, concrete, relates to the online potentiometric titration system of a kind of total closed type.

Background technology

Raw materials used some is more responsive to compositions such as the moisture existed in air and oxygen for current pharmacy or chemical field, if the titration of potentiometric titration method routinely, sample can be caused in sampling and preprocessing process to have partial loss, cause analysis result inaccurate, therefore, be applicable to the system of online potentiometric titration, be still further improved.

Utility model content

The utility model is intended to solve one of technical matters in correlation technique at least to a certain extent or at least provide a kind of useful business to select.For this reason, an object of the present utility model provides a kind of total closed type online potentiometric titration system, utilizes this system, and can eliminate the loss of sample in pre-service and sampling titration process, whole titration system is in full-closed environment.

Thus, in one side of the present utility model, propose the online potentiometric titration system of a kind of total closed type.According to embodiment of the present utility model, this system comprises: sample pretreatment unit, described sample pretreatment unit comprises sampler and pre-service cup, described sampler comprises the first inlet, the second inlet, the 3rd inlet, the first peristaltic pump and the first liquid outlet, described pre-service cup is connected with the first liquid outlet of described sampler, described pre-service cup with precision weighing device, and the cup of described pre-service cup is formed with accurate volume markings and the second liquid outlet; Dosing unit, described dosing unit comprises quantitative sampling device and the second peristaltic pump, and described quantitative sampling device is connected with the second liquid outlet of described pre-service cup; Titration unit, described titration unit comprises titration cup and titration apparatus, described titration cup has the 4th inlet and the 5th inlet, and described titration cup is connected with described dosing unit by the 4th inlet, and described titration cup is connected with described titration apparatus by described 5th inlet; Described titration apparatus comprises piston tube, piston rod, buret and linear stepping motor, described piston rod is connected with the output shaft of described linear stepping motor, described titration apparatus is connected with the 5th inlet of described titration cup by described buret, and described titration cup is connected with waste liquid bottle by waste liquid outlet; Cleaning unit, described cleaning unit comprises washing lotion outlet and valve, and described washing lotion outlet is connected with the 3rd inlet of described sample pretreatment unit, and described valve is arranged between described cleaning unit and described sample pretreatment unit.

Thus, can ensure that the impermeability of whole system is good, realize omnidistance continued operation, and artificially need not drip the operations such as solvent, and then can avoid, because sample contacts air causes sample loss, making titration results on the low side.And systematic automatic operation, measurement result accuracy can be ensured.Described sample pretreatment unit, can avoid the loss of sample in sampling, preprocessing process; Its meausring apparatus and pre-service cup accurate volume markings with it, can realize the quantitative process for preparation of sample in preprocessing process; Described dosing unit, be connected by second liquid outlet of quantitative sampling device with described pre-service cup, ensure that sample is from the continuity and the leakproofness that are sampled to dosing process, by quantitative sampling device, precision pipettes pretreatment sample solution and the titration pre-treatment reagent of concentration known; Described titration unit, is connected with described dosing unit by the 4th inlet, ensures that sample is from dosing unit to the continuity of titration unit and leakproofness; Described cleaning unit, is connected with described 3rd inlet by washing lotion outlet, ensures that titration system is from sample pretreatment to the continuity of last cleaning systems process and leakproofness.

In addition, following additional technical characteristic can also be had according to the online potentiometric titration system of the total closed type of the utility model embodiment:

Optional, described pre-service cup has the first magnetic stirring apparatus.Thus, can ensure that solution in pre-service cup is through magnetic agitation, can fully mix.

Optional, described first magnetic stirring apparatus has the first magnetic force generator and the first magnetic rotor further.Described first magnetic rotor can be placed in described pre-service cup.

Optional, described quantitative sampling device is quantitative sampling pin.Described quantitative sampling pin can be plurality of specifications, such as 5ml, 10ml, 15ml, 20ml.Thus, online titration system of the present utility model is made to be applicable to the titration of different sample.

Optional, described titration cup has the second magnetic stirring apparatus.Thus, can ensure that solution in titration cup is through magnetic agitation, can fully mix.

Optional, described second magnetic stirring apparatus has the second magnetic force generator and the second magnetic rotor further.Described second magnetic rotor can be placed in described titration cup.

Optional, the first inlet of described sampler is connected with the first closed container being contained with testing sample.Thus, first testing sample is entered in pre-service cup by the first peristaltic pump.

Optional, the second inlet of described sampler is connected with the second closed container being contained with pretreating reagent.Thus, pretreating reagent is then entered in pre-service cup by the first peristaltic pump.

Optional, described titration apparatus has the 6th inlet further, and described 6th inlet is connected with the 3rd closed container being contained with volumetric soiutions.Thereby, it is possible to volumetric soiutions is added dropwise in titration cup by buret based on titration apparatus.

Optional, described piston tube is right cylinder hollow glass tube.Optional, the internal diameter of described glass tube immobilizes, and thus, can ensure that sample volume accuracy is high, precision and reproducible.

Optional, described sampler also comprises the 7th inlet, and the 7th inlet of described sampler is connected with the 4th closed container, and described 7th inlet is one or more, and described 4th closed container is contained with testing sample or pretreating reagent.Also namely, it is more than 3 that the inlet of sampler can continue expansion, and is not limited to and only has the first inlet, the second inlet, the 3rd inlet.Thus, can the needs of preprocessing process per sample, different inlet connects different solution tanks, for holding different sample and pretreating reagent.

Additional aspect of the present utility model and advantage will part provide in the following description, and part will become obvious from the following description, or be recognized by practice of the present utility model.

Accompanying drawing explanation

Fig. 1 is the structural representation according to the online potentiometric titration system of the total closed type of the utility model embodiment; And

Fig. 2 is the structural representation of the titration apparatus according to the online potentiometric titration system of the total closed type of the utility model embodiment.

Embodiment

Be described below in detail embodiment of the present utility model, the example of described embodiment is shown in the drawings, and wherein same or similar label represents same or similar element or has element that is identical or similar functions from start to finish.Be exemplary below by the embodiment be described with reference to the drawings, be intended to for explaining the utility model, and can not be interpreted as restriction of the present utility model.

In description of the present utility model, it will be appreciated that, term " " center ", " longitudinal direction ", " transverse direction ", " length ", " width ", " thickness ", " on ", D score, " front ", " afterwards ", " left side ", " right side ", " vertically ", " level ", " top ", " end ", " interior ", " outward ", " clockwise ", " counterclockwise ", " axis ", " radial direction ", orientation or the position relationship of the instruction such as " circumference " are based on orientation shown in the drawings or position relationship, only the utility model and simplified characterization for convenience of description, instead of indicate or imply that the device of indication or element must have specific orientation, with specific azimuth configuration and operation, therefore can not be interpreted as restriction of the present utility model.

In addition, term " first ", " second " only for describing object, and can not be interpreted as instruction or hint relative importance or imply the quantity indicating indicated technical characteristic.Thus, be limited with " first ", the feature of " second " can express or impliedly comprise at least one this feature.In description of the present utility model, the implication of " multiple " is at least two, such as two, three etc., unless otherwise expressly limited specifically.

In the utility model, unless otherwise clearly defined and limited, the term such as term " installation ", " being connected ", " connection ", " fixing " should be interpreted broadly, and such as, can be fixedly connected with, also can be removably connect, or integral; Can be mechanical connection, also can be electrical connection; Can be directly be connected, also indirectly can be connected by intermediary, can be the connection of two element internals or the interaction relationship of two elements, unless otherwise clear and definite restriction.For the ordinary skill in the art, the concrete meaning of above-mentioned term in the utility model can be understood as the case may be.

In the utility model, unless otherwise clearly defined and limited, fisrt feature second feature " on " or D score can be that the first and second features directly contact, or the first and second features are by intermediary indirect contact.And, fisrt feature second feature " on ", " top " and " above " but fisrt feature directly over second feature or oblique upper, or only represent that fisrt feature level height is higher than second feature.Fisrt feature second feature " under ", " below " and " below " can be fisrt feature immediately below second feature or tiltedly below, or only represent that fisrt feature level height is less than second feature.

Be described in detail below with reference to the online potentiometric titration system of the total closed type of Fig. 1 to the utility model embodiment:

According to the embodiment of utility model, the online potentiometric titration system of total closed type comprises: sample pretreatment unit 1000, dosing unit 2000, titration unit 3000 and cleaning unit 4000.

According to an embodiment of the present utility model, sample pretreatment unit 1000 comprises sampler 100, pre-service cup 200.Wherein, sampler 100 comprises the first inlet 110, second inlet 120, the 3rd inlet 130, first peristaltic pump 140 and the first liquid outlet 150, pre-service cup 200 is connected with the first liquid outlet 150 of sampler 100, pre-service cup 200 is with precision weighing device 210, and the cup of described pre-service cup 200 being formed with accurate volume markings and the second liquid outlet 220, pre-service cup 200 is positioned on the first magnetic stirring apparatus 220; Dosing unit 2000 comprises quantitative sampling device 300, second peristaltic pump 400, and described quantitative sampling device 300 is connected with the second liquid outlet 220 of pre-service cup 200; Titration unit 3000 comprises titration cup 500, titration apparatus 600, described titration cup 500 has the waste liquid outlet (not shown) bottom the 4th inlet 510, the 5th inlet 520 and titration cup, and titration cup 500 is connected with dosing unit 2000 by the 4th inlet 510, described titration cup 500 is connected with titration apparatus 600 by the 5th inlet 520.Cleaning unit 4000 comprises washing lotion outlet 700 and valve 800, and washing lotion outlet 700 is connected with the 3rd inlet 130 of sample pretreatment unit 1000, and described valve 800 is arranged between cleaning unit 4000 and sample pretreatment unit 1000.

According to specific embodiment of the utility model, with reference to Fig. 2, titration apparatus 600 comprises: buret 610, linear stepping motor 620 and injection port conversion equipment 630.Wherein, buret 610 comprises piston tube (not shown) and piston rod (not shown), piston rod is connected with the transmission shaft of linear stepping motor 620, titration apparatus 600 is connected with the 5th inlet 520 of titration cup 500 by injection port conversion equipment 630, buret 610 is connected with vs storer 651 by injection port conversion equipment 630, and titration cup 500 is connected with waste liquid bottle by the waste liquid outlet (not shown) bottom titration cup.

According to embodiment of the present utility model, pre-service cup 200 has the first magnetic stirring apparatus 230.Thus, can ensure that solution in pre-service cup 200 is through magnetic agitation, can fully mix.

According to embodiment of the present utility model, the first magnetic stirring apparatus 230 has the first magnetic force generator 231 (not shown) and the first magnetic rotor 232 further.First magnetic rotor 232 can be placed in pre-service cup 200.

According to embodiment of the present utility model, quantitative sampling device 300 is quantitative sampling pin.Described quantitative sampling pin can be plurality of specifications, such as: 5ml, 10ml, 15ml, 20ml, thus, makes online titration system of the present utility model be applicable to the titration of different sample.

According to embodiment of the present utility model, described titration cup 500 has the second magnetic stirring apparatus 530.Thus, can ensure that solution in titration cup 500 is through magnetic agitation, can fully mix.

According to embodiment of the present utility model, the second magnetic stirring apparatus 530 has the second magnetic force generator 531 (not shown) and the second magnetic rotor 532 further.Second magnetic rotor 532 can be placed in titration cup 500.

According to embodiment of the present utility model, the first inlet 110 of sampler 100 is connected with the first closed container 111 being contained with testing sample.Thus, first testing sample is entered in pre-service cup 200 by the first peristaltic pump 140.

According to embodiment of the present utility model, the second inlet 120 of sampler 100 is connected with the second closed container 121 being contained with pretreating reagent.Thus, pretreating reagent is then entered in pre-service cup 200 by the first peristaltic pump 140.

According to embodiment of the present utility model, described titration apparatus 600 has the 6th inlet 650 further, and described 6th inlet 650 is connected with the 3rd closed container 651 being contained with volumetric soiutions.Thereby, it is possible to volumetric soiutions is added dropwise in titration cup 500 by buret 630 based on titration apparatus 600.

According to embodiment of the present utility model, described sampler also comprises the 7th inlet (not shown), 7th inlet of described sampler is connected with the 4th closed container (not shown), described 7th inlet is one or more, and described 4th closed container is contained with testing sample or pretreating reagent.Also namely, it is more than 3 that the inlet of sampler can continue expansion, and is not limited to and only has the first inlet, the second inlet, the 3rd inlet.Thus, can the needs of preprocessing process per sample, different inlet connects different solution tanks, for holding different sample and pretreating reagent.

According to embodiment of the present utility model, piston tube 611 is right cylinder hollow glass tube.According to specific embodiment of the utility model, the internal diameter of described glass tube immobilizes, and thus, can ensure that sample volume accuracy is high, precision and reproducible.

According to embodiment of the present utility model, the workflow of the online potentiometric titration system of total closed type of the present utility model is: sample and pretreating reagent are positioned in the first closed container 111 and the second closed container 112 respectively, by the first peristaltic pump 140, sample is pipetted in pre-service cup 200 from the first closed container 111, and by the accurately weighed sample volume W of precision weighing device 210, by the first peristaltic pump 140, preprocessing solution is pipetted in pre-service cup 200 from the second closed container 112 again, stop after reaching volume markings V1 pipetting.Open simultaneously and from stirring apparatus 220, mixed solution is stirred for the first time.Then open the second peristaltic pump 400 quantitative sampling pin 300 from pre-service cup 200, quantitatively to pipette mixed solution V2 enter in titration cup 500 by the 4th inlet 510, open the second magnetic stirring apparatus 530 simultaneously, then reagent needed for titration pre-treatment is added from the 5th inlet 520, open titration apparatus 600 simultaneously, by injection port conversion equipment 630, feed pathway is gone to ab passage, buret 610 is full of vs.And then by injection port conversion equipment 630, feed pathway is gone to bc passage, start titration, final consumption vs volume V3.Titration is complete, by the second peristaltic pump 400, waste liquid is drained into waste liquid bottle from waste liquid outlet, then cleaning unit is opened, pretreatment unit, dosing unit, titration unit are cleaned successively from pretreatment unit, the waste liquid after cleaning is discharged from waste liquid outlet (being positioned at bottom titration cup).The content of sample can be calculated as follows:

$\frac{C_1\·V_3\·D}{C_0\·\frac{W}{V_1}\·V_2}\×100\%,$

In formula: C₁for the actual concentrations of vs;

C₀for the theoretical concentration of vs;

D is the titer of sample.

Make an explanation below in conjunction with the scheme of embodiment to utility model.It will be understood to those of skill in the art that the following examples only for illustration of the utility model, and should not be considered as limiting scope of the present utility model.Unreceipted concrete technology or condition in embodiment, according to the technology described by the document in this area or condition or carry out according to product description.Agents useful for same or the unreceipted production firm person of instrument, being can by the conventional products of commercial acquisition.

Embodiment 1:

Utilize the total closed type of the present utility model online potentiometric titration system titration system shown in Fig. 1, titration detection is carried out to testing sample pyridine-3-sulfonic acid chloride, specific as follows:

Sample (pyridine-3-sulfonic acid chloride) and acetone (pretreating reagent) are positioned over respectively in the first closed container 111 and the second closed container 112, by the first peristaltic pump 140, pyridine-3-sulfonic acid chloride is pipetted in pre-service cup 200 from the first closed container 111, and by the accurately weighed sample of precision weighing device 210 (pyridine-3-sulfonic acid chloride) sampling amount W (0.6012g), by the first peristaltic pump 140, acetone is pipetted in pre-service cup 200 from the second closed container 112 again, reach volume markings V1 (50ml) to stop afterwards pipetting, open simultaneously and from stirring apparatus 220, mixed solution is stirred for the first time.

Open the second peristaltic pump 400 quantitative sampling pin 300 from pre-service cup 200, quantitatively to pipette mixed solution V2 (10ml) enter in titration cup 500 by the 4th inlet 510, open the second magnetic stirring apparatus 530 simultaneously, then reagent 1.5mol/L sodium hydroxide solution 2ml needed for titration pre-treatment and 10% salpeter solution 5ml is added from the 5th inlet 520, open titration apparatus 600 simultaneously, by injection port conversion equipment 630, feed pathway is gone to ab passage, buret 610 is full of 0.1mol/L silver nitrate titration liquid (its theoretical concentration C₀for 0.1mol/L, actual concentrations C1=0.1005mol/L), and then by injection port conversion equipment 630, feed pathway is gone to bc passage, start titration, the final silver nitrate titration liquid that consumes of record amasss V3 (6.834ml).

Titration is complete, by the second peristaltic pump 400, waste liquid is drained into waste liquid bottle from waste liquid outlet, then open cleaning unit, pretreatment unit, dosing unit, titration unit are cleaned successively from pretreatment unit, the waste liquid after cleaning is discharged from waste liquid outlet.

Then, the content of sample pyridine-3-sulfonic acid chloride is calculated as follows:

$\frac{C_1\·V_3\·D}{C_0\·\frac{W}{V_1}\·V_2}\×100\%,$

In formula: C₁for the actual concentrations of vs;

C₀for the theoretical concentration of vs;

D is the titer (the present embodiment is 17.76) of sample,

Then, the content of pyridine-3-sulfonic acid chloride in the present embodiment:$\frac{0.1005\×6.834\×17.76}{0.1\×\frac{0.6012}{50}\×10}\×100\%=99.96\%.$

From result, utilize titration system of the present invention to carry out titration and detect discovery, acetone energy sample dissolution completely, makes sample be dispersed in wherein, thus makes titration results accurately reliable; Reduce the consumption of NaOH and nitric acid when not affecting titration accuracy, environmental protection more economically simultaneously; And the preprocessing process of sample is simple, consuming time short, thus substantially reduces proving time, make inspection work more efficient quick.

In the description of this instructions, specific features, structure, material or feature that the description of reference term " embodiment ", " some embodiments ", " example ", " concrete example " or " some examples " etc. means to describe in conjunction with this embodiment or example are contained at least one embodiment of the present utility model or example.In this manual, to the schematic representation of above-mentioned term need not for be identical embodiment or example.And the specific features of description, structure, material or feature can combine in one or more embodiment in office or example in an appropriate manner.In addition, when not conflicting, the feature of the different embodiment described in this instructions or example and different embodiment or example can carry out combining and combining by those skilled in the art.

Although illustrate and described embodiment of the present utility model above, be understandable that, above-described embodiment is exemplary, can not be interpreted as restriction of the present utility model, those of ordinary skill in the art can change above-described embodiment, revises, replace and modification in scope of the present utility model.

Claims (10)

1. the online potentiometric titration system of total closed type, is characterized in that, comprising:

Sample pretreatment unit, described sample pretreatment unit comprises sampler and pre-service cup, described sampler comprises the first inlet, the second inlet, the 3rd inlet, the first peristaltic pump and the first liquid outlet, described pre-service cup is connected with the first liquid outlet of described sampler, described pre-service cup with precision weighing device, and the cup of described pre-service cup is formed with accurate volume markings and the second liquid outlet;

Dosing unit, described dosing unit comprises quantitative sampling device and the second peristaltic pump, and described quantitative sampling device is connected with the second liquid outlet of described pre-service cup;

Titration unit, described titration unit comprises titration cup and titration apparatus, described titration cup has the 4th inlet and the 5th inlet, and described titration cup is connected with described dosing unit by the 4th inlet, and described titration cup is connected with described titration apparatus by described 5th inlet; Described titration apparatus comprises injection port conversion equipment, piston tube, piston rod, buret and linear stepping motor, described injection port conversion equipment is connected with piston tube, described piston rod is connected with the transmission shaft of described linear stepping motor, and described titration apparatus is connected with the 5th inlet of described titration cup by described buret; And

Cleaning unit, described cleaning unit comprises washing lotion outlet and valve, and described washing lotion outlet is connected with the 3rd inlet of described sample pretreatment unit, and described valve is arranged between described cleaning unit and described sample pretreatment unit.

2. titration system according to claim 1, is characterized in that, described pre-service cup has the first magnetic stirring apparatus.

3. titration system according to claim 2, is characterized in that, described first magnetic stirring apparatus has the first magnetic force generator and the first magnetic rotor further.

4. titration system according to claim 1, is characterized in that, described quantitative sampling device is quantitative sampling pin.

5. titration system according to claim 1, is characterized in that, described titration cup has the second magnetic stirring apparatus.

6. titration system according to claim 5, is characterized in that, described second magnetic stirring apparatus has the second magnetic force generator and the second magnetic rotor further.

7. titration system according to claim 1, is characterized in that, the first inlet of described sampler is connected with the first closed container being contained with testing sample.

8. titration system according to claim 1, is characterized in that, the second inlet of described sampler is connected with the second closed container being contained with pretreating reagent.

9. titration system according to claim 1, is characterized in that, described titration apparatus has the 6th inlet further, and described 6th inlet is connected with the 3rd closed container being contained with volumetric soiutions.

10. titration system according to claim 1, it is characterized in that, described sampler also comprises the 7th inlet, 7th inlet of described sampler is connected with the 4th closed container, described 7th inlet is one or more, and described 4th closed container is contained with testing sample or pretreating reagent.