技术领域technical field
本实用新型涉及一种闭环光刺激器，具体涉及一种用于脊髓功能调控的闭环光刺激系统。The utility model relates to a closed-loop optical stimulator, in particular to a closed-loop optical stimulation system for spinal cord function regulation.
背景技术Background technique
脊髓是中枢神经系统中极易受损的部位，脊髓损伤的致残率高，严重危及人类的健康。脊髓损伤后的修复一直是医学领域的难点。脊髓损伤后神经生长因子(NGF)在一定的条件下，可促进未损伤神经元出芽，重建被破坏的神经回路。但在没有外界干预的情况下，中重度损伤内源性NGF表达量不足以起到保护和修复的作用，且维持时间较短。The spinal cord is an extremely vulnerable part of the central nervous system. Spinal cord injury has a high disability rate and seriously endangers human health. The repair of spinal cord injury has always been a difficult point in the medical field. After spinal cord injury, nerve growth factor (NGF) can promote the sprouting of uninjured neurons and rebuild the damaged neural circuits under certain conditions. However, in the absence of external intervention, the expression of endogenous NGF in moderate to severe injury is not enough to protect and repair, and the maintenance time is short.
目前，细胞移植和基因治疗是脊髓损伤治疗的重要手段，在动物实验中取得了好的效果，但离临床应用还很远。细胞移植治疗所需的理想细胞量、移植效果的维持时间以及如何应用神经营养因子、免疫抑制药物等一系列问题。脊髓损伤的基因治疗也面临着不少问题：(1)中枢神经系统排斥反应；(2)移植细胞在宿主体内不能长期存活；(3)遗传修饰细胞移植后，转基因表达随时间延长而下降，失去治疗作用；(4)安全性问题，如外源基因的致癌性。At present, cell transplantation and gene therapy are important methods for the treatment of spinal cord injury, and have achieved good results in animal experiments, but they are still far from clinical application. A series of issues such as the ideal cell volume required for cell transplantation, the maintenance time of the transplantation effect, and how to apply neurotrophic factors and immunosuppressive drugs. Gene therapy for spinal cord injury also faces many problems: (1) central nervous system rejection; (2) transplanted cells cannot survive for a long time in the host body; (3) after transplantation of genetically modified cells, the expression of transgenes decreases with time, Loss of therapeutic effect; (4) safety issues, such as carcinogenicity of exogenous genes.
近年来，脊髓电刺激技术在抑制疼痛、治疗脊髓损伤和植物人唤醒等方面发展很快。这种治疗方法是将电极直接放在脊髓相关位置，通过刺激器产生电刺激脉冲来治疗相关疾病，已在临床上取得了可喜的效果。In recent years, spinal cord electrical stimulation technology has developed rapidly in pain suppression, treatment of spinal cord injury and vegetative awakening. This treatment method is to place the electrodes directly on the relevant parts of the spinal cord, and use the stimulator to generate electrical stimulation pulses to treat related diseases. It has achieved gratifying clinical results.
随着近几年光感基因调控技术的发展，人们发现光刺激可以更为精准地针对特定神经元进行刺激，将光遗传学应用于脊髓刺激，有望取得比电刺激更好的效果。光遗传学以光学和光遗传基因工程学为基础，将视蛋白基因加上特异启动子通过病毒转染导入特定的神经元类群，然后通过特定波长的光刺激来兴奋或抑制该类神经元的生理活动。例如，蓝光刺激可兴奋带光敏蛋白ChR2的神经元，而在黄光的刺激下，带光敏蛋白NaHR的神经元活动将被抑制。相对于电刺激，光遗传学实现了对特定神经元的精确靶向刺激，且避免了电流对人体组织的伤害。With the development of light-sensing gene regulation technology in recent years, it has been found that light stimulation can stimulate specific neurons more precisely. Applying optogenetics to spinal cord stimulation is expected to achieve better results than electrical stimulation. Optogenetics is based on optics and optogenetic genetic engineering. The opsin gene plus a specific promoter is introduced into a specific neuron group through viral transfection, and then stimulated or inhibited by specific wavelengths of light. Activity. For example, blue light stimulation can excite neurons with light-sensitive protein ChR2, while under the stimulation of yellow light, the activity of neurons with light-sensitive protein NaHR will be inhibited. Compared with electrical stimulation, optogenetics achieves precise targeted stimulation of specific neurons, and avoids the damage of current to human tissues.
现有技术中，对脊髓的单向光刺激无法根据脊髓状态作出调节，故而调控效果受限。In the prior art, the unidirectional light stimulation to the spinal cord cannot be adjusted according to the state of the spinal cord, so the regulation effect is limited.
实用新型内容Utility model content
为克服现有技术的不足，本实用新型的目的是提供一种用于脊髓功能调控的闭环光刺激器系统，该系统旨在通过柔性光-电电极采集使用者的脊髓神经传导电信号，对其进行分析以确定脊髓状态，并根据相应算法驱动LED对移植入脊髓特定部位的带光敏蛋白的神经元进行光调控，有针对性地修复损伤后的脊髓。In order to overcome the deficiencies in the prior art, the purpose of this utility model is to provide a closed-loop optical stimulator system for spinal cord function regulation, which aims to collect the user's spinal nerve conduction electrical signal through flexible photo-electric electrodes, and to It conducts analysis to determine the state of the spinal cord, and drives LEDs according to the corresponding algorithm to light-regulate the neurons with light-sensitive proteins transplanted into specific parts of the spinal cord to repair the damaged spinal cord in a targeted manner.
为实现上述目的，本实用新型通过以下技术方案实现：In order to achieve the above object, the utility model is realized through the following technical solutions:
本实用新型所述的用于脊髓功能调控的闭环光刺激系统，包括：The closed-loop optical stimulation system for spinal cord function regulation described in the utility model includes:
柔性光-电电极，其包括用于采集神经电信号的金属电极和用于光刺激的LED；Flexible photo-electric electrodes, which include metal electrodes for collecting nerve electrical signals and LEDs for light stimulation;
信号采集单元，其与所述柔性光-电电极通讯连接，以接收所述金属电极采集到的脊髓神经传导电信号；A signal acquisition unit, which is connected in communication with the flexible photoelectric electrode, to receive the electrical signal of the spinal nerve conduction collected by the metal electrode;
主控单元，其与所述信号采集单元通讯连接，且根据采集到的脊髓神经传导电信号，调整LED驱动指令；a main control unit, which communicates with the signal acquisition unit, and adjusts the LED driving instruction according to the collected spinal nerve conduction electrical signal;
LED驱动单元，其与所述主控单元通讯连接，且根据所述LED驱动指令，驱动所述LED工作；an LED driving unit, which is connected in communication with the main control unit, and drives the LED to work according to the LED driving instruction;
供电单元，其向所述柔性光-电电极、主控单元、信号采集单元和LED驱动单元供电。A power supply unit, which supplies power to the flexible photo-electric electrodes, the main control unit, the signal acquisition unit and the LED drive unit.
优选的是，所述的用于脊髓功能调控的闭环光刺激系统，其中，还包括：Preferably, the closed-loop optical stimulation system for spinal cord function regulation further includes:
上位机，其通过通讯单元与所述主控单元通讯，以保存其中的信息。The upper computer communicates with the main control unit through the communication unit to save the information therein.
优选的是，所述的用于脊髓功能调控的闭环光刺激系统，其中，还包括：Preferably, the closed-loop optical stimulation system for spinal cord function regulation further includes:
固定环，其为弧形弹片，环绕在受者的躯体上；The fixing ring, which is an arc-shaped shrapnel, surrounds the recipient's body;
转接座，其套设在所述固定环的中部，且所述转接座的两侧设置有排线接口，所述排线接口处还分别设置有翻盖一和翻盖二，所述翻盖一和翻盖二的一端均枢接在转接座上，另一端可卡接在转接座上，以夹紧排线；An adapter seat, which is set in the middle of the fixed ring, and the two sides of the adapter seat are provided with a cable interface, and the cable interface is also provided with a flip cover 1 and a flip cover 2 respectively, and the flip cover 1 One end of flip cover 2 is pivotally connected to the adapter seat, and the other end can be clamped on the adapter seat to clamp the cable;
其中，所述柔性光-电电极通过排线连接至转接座，信号采集单元和LED驱动单元也通过排线连接至转接座。Wherein, the flexible photoelectric electrode is connected to the adapter seat through a cable, and the signal acquisition unit and the LED driving unit are also connected to the adapter seat through a cable.
优选的是，所述的用于脊髓功能调控的闭环光刺激系统，其中，所述柔性光-电电极设置在柔性电路板上，在所述柔性电路板的一端的中部伸出LED，在所述LED的两侧分别伸出一个金属微电极；Preferably, in the closed-loop optical stimulation system for spinal cord function regulation, wherein the flexible photo-electric electrode is arranged on a flexible circuit board, an LED protrudes from the middle of one end of the flexible circuit board, and A metal microelectrode protrudes from both sides of the LED;
优选的是，所述的用于脊髓功能调控的闭环光刺激系统，其中，所述信号采集单元可采用双电极输入或三电极输入。Preferably, in the closed-loop light stimulation system for spinal cord function regulation, the signal acquisition unit can adopt double-electrode input or three-electrode input.
优选的是，所述的用于脊髓功能调控的闭环光刺激系统，其中，所述柔性光-电电极中的金属电极与LED电极可集成为同一部件，或分立为不同部件。Preferably, in the closed-loop photo-stimulation system for spinal cord function regulation, the metal electrodes and the LED electrodes in the flexible photo-electric electrodes can be integrated into the same part or separated into different parts.
优选的是，所述的用于脊髓功能调控的闭环光刺激系统，其中，柔性光-电电极通过手术植入体内，贴合于脊髓神经上，LED位于受损部位而金属电极则位于受损部位前后两端。Preferably, in the closed-loop optical stimulation system for spinal cord function regulation, the flexible photo-electric electrodes are implanted in the body through surgery and attached to the spinal nerves, the LED is located at the damaged part and the metal electrode is located at the damaged site. front and rear ends of the site.
优选的是，所述的用于脊髓功能调控的闭环光刺激系统，其中，所述柔性光-电电极可以是平面电极或三维多触点金属电极。Preferably, in the closed-loop photo-stimulation system for spinal cord function regulation, the flexible photo-electric electrodes can be planar electrodes or three-dimensional multi-contact metal electrodes.
优选的是，所述的用于脊髓功能调控的闭环光刺激系统，其中，所述LED有两个或两个以上。Preferably, in the closed-loop optical stimulation system for regulating spinal cord function, there are two or more LEDs.
优选的是，所述的用于脊髓功能调控的闭环光刺激系统，所述LED可统一发光模式或独立可控。Preferably, in the closed-loop optical stimulation system for spinal cord function regulation, the LEDs can be in a uniform light emitting mode or independently controllable.
本实用新型的有益效果是：本实用新型利用柔性材料制作的柔性光-电电极采集脊髓神经传导电信号和LED进行光刺激，同时具备脊髓神经传导电信号采集功能和光刺激功能，两者通过算法实现对脊髓的闭环光刺激，主控单元分析采集到的多路信号并对刺激模式进行反馈，该系统解决了单向光刺激调控受限的问题，可自适应调控具备光敏特性的神经元所在的整个神经通路，更适应不同个体的差异性，从而达到更好的调控效果。The beneficial effects of the utility model are: the utility model utilizes flexible photo-electric electrodes made of flexible materials to collect spinal nerve conduction electrical signals and LEDs for light stimulation, and simultaneously has the functions of spinal nerve conduction electrical signal acquisition and light stimulation functions, both of which pass the algorithm Realize the closed-loop optical stimulation of the spinal cord, the main control unit analyzes the collected multi-channel signals and gives feedback to the stimulation mode. This system solves the problem of limited regulation of one-way optical stimulation, and can adaptively regulate the location of neurons with photosensitive characteristics. The entire neural pathway is more adaptable to the differences of different individuals, so as to achieve better regulation effect.
附图说明Description of drawings
图1为本实用新型一实施例所述的用于脊髓功能调控的闭环光刺激器系统的结构框图。FIG. 1 is a structural block diagram of a closed-loop optical stimulator system for spinal cord function regulation according to an embodiment of the present invention.
图2为本实用新型一实施例所述的用于脊髓功能调控的闭环光刺激器系统中的转接板结构示意图。Fig. 2 is a schematic structural diagram of an adapter plate in a closed-loop optical stimulator system for regulating spinal cord function according to an embodiment of the present invention.
图3为本实用新型一实施例所述的用于脊髓功能调控的闭环光刺激器系统中的柔性光-电电极结构示意图。Fig. 3 is a schematic diagram of the structure of the flexible photoelectric electrode in the closed-loop photostimulator system for spinal cord function regulation according to an embodiment of the present invention.
具体实施方式Detailed ways
下面结合附图对本实用新型做进一步的详细说明，以令本领域技术人员参照说明书文字能够据以实施。The utility model will be described in further detail below in conjunction with the accompanying drawings, so that those skilled in the art can implement it by referring to the description.
本实施例针对的是小鼠的脊髓损伤修复，本实用新型所述的用于脊髓功能调控的闭环光刺激系统，主要包括：This embodiment is aimed at the repair of spinal cord injury in mice. The closed-loop optical stimulation system for spinal cord function regulation described in the utility model mainly includes:
柔性光-电电极4，参阅图3，为所述柔性光-电电极结构示意图，包括用于采集神经电信号的金属电极41和用于光刺激的LED42；The flexible photo-electric electrode 4, referring to Fig. 3, is a structural schematic diagram of the flexible photo-electric electrode, including a metal electrode 41 for collecting nerve electrical signals and an LED 42 for photostimulation;
信号采集单元23，其与所述柔性光-电电极通讯连接，以接收所述金属电极采集到的脊髓神经传导电信号；A signal acquisition unit 23, which is connected in communication with the flexible photoelectric electrode, to receive the electrical signal of the spinal nerve conduction collected by the metal electrode;
主控单元22，为控制器(STM32L151CBT6)，通过SPI接口与信号采集单元(ADS1292)通信，设置ADS1292的采样频率和工作模式，并获取两路24位数字信号；通过特定算法对采集到的脊髓神经传导电信号进行分析，从而实时调节刺激参数，包括刺激波形的周期、脉宽和幅度，按照参数调整LED驱动指令；The main control unit 22 is the controller (STM32L151CBT6), communicates with the signal acquisition unit (ADS1292) through the SPI interface, sets the sampling frequency and working mode of the ADS1292, and obtains two 24-bit digital signals; The nerve conduction electrical signal is analyzed to adjust the stimulation parameters in real time, including the cycle, pulse width and amplitude of the stimulation waveform, and adjust the LED drive command according to the parameters;
LED驱动单元24，为STM32L151CBT6内置DA加上运放AD8603，LED驱动单元根据LED驱动指令，以驱动所述LED工作；The LED drive unit 24 is a STM32L151CBT6 built-in DA plus an operational amplifier AD8603, and the LED drive unit drives the LED to work according to the LED drive command;
供电单元25，包括锂电池和电压芯片ADP151，其向柔性光-电电极、主控单元22、信号采集单元和LED驱动单元供电。The power supply unit 25 includes a lithium battery and a voltage chip ADP151, which supplies power to the flexible photo-electric electrode, the main control unit 22, the signal acquisition unit and the LED drive unit.
本实用新型所述的用于脊髓功能调控的闭环光刺激系统，还可以包括下述情况。The closed-loop optical stimulation system for spinal cord function regulation described in the utility model may also include the following conditions.
进一步的，还包括上位机1，其中的计算机11通过通讯单元12和21与所述主控单元通讯，将电信号、光刺激参数及电池电量状态通过无线通信单元传输至上位机显示或保存。Further, it also includes a host computer 1, in which the computer 11 communicates with the main control unit through the communication units 12 and 21, and transmits electrical signals, light stimulation parameters and battery power status to the host computer through the wireless communication unit for display or storage.
本实用新型还可以包括：固定环，其为弧形弹片，环绕在受者的躯体上，这里固定环是环绕在小鼠躯体上；The utility model can also include: a fixing ring, which is an arc-shaped shrapnel, and wraps around the body of the recipient, where the fixing ring wraps around the body of the mouse;
转接座32，如附图2所示，其套设在所述固定环的中部，且所述转接座的两侧设置有排线接口，所述排线接口处还分别设置有翻盖一31和翻盖二34，所述翻盖一和翻盖二的一端均枢接在转接座上，另一端可卡接在转接座上，以夹紧排线35；The adapter seat 32, as shown in Figure 2, is sleeved in the middle of the fixed ring, and the two sides of the adapter seat are provided with a cable interface, and the cable interface is also provided with a flip cover respectively. 31 and the flip cover 2 34, one end of the flip cover 1 and the flip cover 2 are both pivotally connected to the adapter seat, and the other end can be clamped on the adapter seat to clamp the cable 35;
其中，所述柔性光-电电极通过排线连接至转接座，信号采集单元和LED驱动单元也通过排线连接至转接座。Wherein, the flexible photoelectric electrode is connected to the adapter seat through a cable, and the signal acquisition unit and the LED driving unit are also connected to the adapter seat through a cable.
进一步的，所述柔性光-电电极设置在柔性电路板上，在所述柔性电路板的一端的中部伸出LED，在所述LED的两侧分别伸出一个金属微电极；其中，LED的放置过程全程在显微镜下进行，用点胶机将导电银胶点到正负电极上，注意不要短路，然后将LED放置其上使正负端与电极对齐，放置一天，使导电银胶固化，随后附上一层聚对二甲苯作为绝缘层；Further, the flexible photo-electric electrode is arranged on a flexible circuit board, an LED protrudes from the middle of one end of the flexible circuit board, and a metal microelectrode protrudes from both sides of the LED; wherein, the LED The whole placement process is carried out under a microscope. Use a dispenser to spot the conductive silver glue on the positive and negative electrodes. Be careful not to short-circuit, then place the LED on it so that the positive and negative ends are aligned with the electrodes, and leave it for a day to cure the conductive silver glue. A layer of parylene is then attached as an insulating layer;
本实用新型还可以包括以下变形：所述信号采集单元可采用双电极输入或三电极输入。即采用三电极输入时，除了位于脊髓神经上LED的两侧的金属电极(一个工作金属电极，及其附近的参比金属电极)，还包括一个共地的电极，由于LED两侧电极放置的位置不同，输入的信号也不一样，所述信号采集单元所采集的信号是工作金属电极相对于参比金属电极的电位，共地电极是用来使电路板和被试者的地在一个平面上，以达到更好的效果；也可以采用双电级输入，即省去上述共地电极，信号采集单元所采集的信号也是工作金属电极相对于参比金属电极的电位，该方法需要通过后端处理来保证输入信号不超过电路板输入范围，该方法更容易实现；The utility model may also include the following modification: the signal acquisition unit may adopt double-electrode input or three-electrode input. That is, when using three-electrode input, in addition to the metal electrodes on both sides of the LED on the spinal nerve (a working metal electrode, and a reference metal electrode nearby), it also includes a common ground electrode, because the electrodes on both sides of the LED are placed The position is different, the input signal is also different, the signal collected by the signal acquisition unit is the potential of the working metal electrode relative to the reference metal electrode, and the common ground electrode is used to make the circuit board and the ground of the subject be in the same plane In order to achieve better results; double-level input can also be used, that is, the above-mentioned common ground electrode is omitted, and the signal collected by the signal acquisition unit is also the potential of the working metal electrode relative to the reference metal electrode. Terminal processing to ensure that the input signal does not exceed the input range of the circuit board, this method is easier to implement;
本实用新型还可以包括下述情况，所述柔性光-电电极中的金属电极与LED电极可集成为同一部件，或分立为不同部件。The utility model may also include the following situation, the metal electrode and the LED electrode in the flexible photo-electric electrode can be integrated into the same part, or separated into different parts.
进一步的，所述柔性光-电电极通过手术植入体内，贴合于脊髓神经上，LED位于受损部位而金属电极则位于受损部位前后两端。Further, the flexible photoelectric electrode is implanted in the body through surgery, and attached to the spinal nerve, the LED is located at the damaged part and the metal electrodes are located at the front and rear ends of the damaged part.
进一步的，所述柔性光-电电极可以是平面电极或三维多触点金属电极。Further, the flexible photo-electric electrode may be a planar electrode or a three-dimensional multi-contact metal electrode.
本实用新型还可以包括以下情况，所述LED可以有两个或两个以上。The present invention may also include the following situation, there may be two or more than two LEDs.
进一步的，所述两个或两个以上的LED可统一发光模式或独立可控，也就是说，几个LED可以以相同的频率、亮度闪烁，也可以各自按照各自不同的频率、亮度闪烁。Further, the two or more LEDs can be in a unified light emitting mode or independently controllable, that is to say, several LEDs can blink at the same frequency and brightness, or can also blink at different frequencies and brightness.
以小鼠的脊髓损伤修复为例，本实用新型所述的用于脊髓功能调控实验的闭环光刺激系统的使用方法如下：Taking the repair of spinal cord injury in mice as an example, the method of using the closed-loop optical stimulation system for spinal cord function regulation experiment described in the utility model is as follows:
步骤1：移植带光敏蛋白的诱导多能干细胞到脊髓损伤部位，待细胞分化后进行光调控。Step 1: Transplant induced pluripotent stem cells with light-sensitive protein to the spinal cord injury site, and perform light regulation after the cells are differentiated.
步骤2：将柔性光-电电极前端植入体内，贴合于脊髓神经上，LED位于受损部位而金属电极则位于受损部位前后两端。Step 2: Implant the front end of the flexible photoelectric electrode into the body and attach it to the spinal nerve. The LED is located at the damaged part and the metal electrodes are located at the front and rear ends of the damaged part.
步骤3：连接柔性光-电电极和转接板，固定转接板，通过排线连接转接板与闭环光刺激模块。Step 3: Connect the flexible photo-electric electrode and the adapter board, fix the adapter board, and connect the adapter board and the closed-loop photostimulation module through the cable.
步骤4：将闭环光刺激器置于背包内，背包由小鼠背负。Step 4: Place the closed-loop photostimulator in the backpack carried by the mouse.
步骤5：打开闭环光刺激器电源开关，使用者通过上位机软件发送“开始”命令，闭环光刺激器开始工作，软件显示采集到的波形和当前的刺激参数。Step 5: Turn on the power switch of the closed-loop optical stimulator, the user sends a "start" command through the host computer software, the closed-loop optical stimulator starts to work, and the software displays the collected waveform and current stimulation parameters.
步骤6：使用者可通过上位机软件发送“暂停”或“终止”命令。Step 6: The user can send a "pause" or "terminate" command through the host computer software.
尽管本实用新型的实施方案已公开如上，但其并不仅仅限于说明书和实施方式中所列运用，它完全可以被适用于各种适合本实用新型的领域，对于熟悉本领域的人员而言，可容易地实现另外的修改，因此在不背离权利要求及等同范围所限定的一般概念下，本实用新型并不限于特定的细节和这里示出与描述的图例。Although the embodiment of the present utility model has been disclosed as above, it is not limited to the use listed in the description and the implementation, and it can be applied to various fields suitable for the present utility model. For those familiar with the art, Further modifications can be readily effected, so the invention is not limited to the specific details and examples shown and described herein without departing from the general concept defined by the claims and their equivalents.
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420588300.1UCN204147437U (en) | 2014-10-11 | 2014-10-11 | A kind of closed loop light stimulus system for spinal function regulation and control |
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420588300.1UCN204147437U (en) | 2014-10-11 | 2014-10-11 | A kind of closed loop light stimulus system for spinal function regulation and control |
| Publication Number | Publication Date |
|---|---|
| CN204147437Utrue CN204147437U (en) | 2015-02-11 |
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201420588300.1UExpired - Fee RelatedCN204147437U (en) | 2014-10-11 | 2014-10-11 | A kind of closed loop light stimulus system for spinal function regulation and control |
| Country | Link |
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| CN (1) | CN204147437U (en) |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104436447A (en)* | 2014-10-11 | 2015-03-25 | 中国科学院苏州生物医学工程技术研究所 | Closed loop photostimulation system used for regulating and controlling functions of spinal cord |
| CN105126258A (en)* | 2015-10-10 | 2015-12-09 | 中国科学院苏州生物医学工程技术研究所 | Wireless program-control light stimulation device |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104436447A (en)* | 2014-10-11 | 2015-03-25 | 中国科学院苏州生物医学工程技术研究所 | Closed loop photostimulation system used for regulating and controlling functions of spinal cord |
| CN104436447B (en)* | 2014-10-11 | 2017-01-11 | 中国科学院苏州生物医学工程技术研究所 | Closed loop photostimulation system used for regulating and controlling functions of spinal cord |
| CN105126258A (en)* | 2015-10-10 | 2015-12-09 | 中国科学院苏州生物医学工程技术研究所 | Wireless program-control light stimulation device |
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| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee | Granted publication date:20150211 Termination date:20191011 |