CN202637725U - Dynamic variable multichannel transcranial magnetic stimulation coil array - Google Patents

Abstract

The utility model discloses a dynamic variable multichannel transcranial magnetic stimulation coil array, and a control method thereof. The coil array comprises a set of evenly-spaced rectilinear wires which are along an S direction, a set of evenly-spaced rectilinear wires which are along a C direction, and control units. The S direction and the C direction correspond to the brain sagittal axis and the brain coronal axis respectively. The set of wires which are along the S direction and the set of wires which are along the C direction are vertical to each other, cross each other, and are insulated from each other, so the mesh-like coil array is formed. The input end or output end of each rectilinear wire is connected with an independent control unit. The coil array is bent into a spherical surface in space, the radian of the spherical surface conforms to the surface profile of a human head, and the whole coil array is in the shape of a helmet and covers the whole head range. By adopting the TMS coil array of the utility model, a plurality of TMS coils can be generated in the whole head range at the same time, and the stimulation area, the stimulation strength and the stimulation mode can be changed. According to the coil array, the multichannel TMS stimulation having a high spatial resolution can be realized, and the advantage of dynamic variability of the stimulation position and the stimulation mode can be realized.

Description

A kind of dynamically changeable multichannel transcranial magnetic stimulation coil array

Technical field

This utility model relates to the bioelectromagnetics technical field, particularly a kind of dynamically changeable multichannel transcranial magnetic stimulation coil array and control method thereof.

Background technology

Magnetic field can penetrate head almost losslessly.Transcranial magnetic stimulation (TMS) produces alternating magnetic field by import pulse current in the TMS coil, and magnetic field penetration head (Fig. 1 .a) is being induced faint faradic current (Fig. 1 .b, Fig. 1 .c) by the cerebral cortex below the stimulation location.If induced current parallels with nerve fiber, thereby can induce stronger transmembrane potential to cause that neuronal cell is movable.TMS is widely used in brain science, Cognitive Science and clinical treatment field at present.

Existing TMS mostly adopts single channel o shape coil (shown in Fig. 1 .b) or figure-eight coil (shown in Fig. 1 .c) to apply TMS to be stimulated.O shape coil can produce toroidal magnetic field in a big way in brain; The essence of figure-eight coil is that the o shape coil of two current opposite in direction closely links to each other, although the electric field intensity of its generation not as o shape coil, can produce the CURRENT DISTRIBUTION of comparatively concentrating in the junction of two o shape coils.Thereby can produce the stimulation of comparatively concentrating.Existing TMS device all is to adopt single channel TMS coil to be positioned over fixing scalp position to stimulate.Based on the Research Requirements in brain science, Cognitive Science and clinical treatment field, implementing multichannel TMS stimulation in complete scope has become development trend.

Exploitation multichannel TMS coil was once attempted in some researchs, realized that so-called multichannel TMS stimulates (Fig. 2) but these researchs just are configured in a plurality of single channel TMS coils the head surface simply.Such as J. Ruohonen (Multichannel magnetic stimulation:improved stimulus targeting, 1996; Focusing and targeting of magneric brain stimulation using multiple coils, 1998; Theory of multichannel magnetic stimulation:toward functional neuromuscular rehabilitation, 1999), SL. Ho(Optimization of array magnetic coil design for functional magnetic stimulation based on improved genetic algorithm, 2009), BY. Han(Multichannel magnetic stimulation system design considering mutual couplings among the stimulation coils, 2004) etc. people's research group proposed with a plurality of single channel o shape coil close-packed arrays form coil arrays concept (Fig. 2. (a)-(c)).And XM. Wang(Design of multi-channel brain magnetic stimulator and ANSYS simulation, 2005) and the people's such as CH. Im (Computer-aided performance evaluation of a multichannel transcranial magnetic stimulation system, 2006) research group then proposed the concept that a plurality of single channel o of dispersed arrangement shape coil consists of multichannel TMS coil array (Fig. 2. (d) (e)).GZ. Xu(The optimal design of magnetic coil in transcranial magnetic stimulation, 2005) etc. people's research then imagine with a plurality of single channel o shape coils superposeed to form in the space multichannel TMS coil array (Fig. 2. (f)).

Above cited scheme is not all broken away from a plurality of single channel o of head surface configuration shape coil and is realized the thinking that multichannel TMS stimulates.Because the restriction of the shape and size of coil itself, and the interval between coil and the coil etc. restricts key element, so that the TMS coil in the such scheme coil array can't tight distribution, namely can't realize high-resolution coil configuration.

On the other hand, TMS is applied in the brain science research, usually need same experiment condition is carried out many experiments, and all need each single channel coil is accurately located to guarantee coil and head one by one in the experiment each time, and the relative position of coil and coil meets predefined requirement.There is numerous single channel coils in the such scheme, these TMS coils are located one by one will causes the complicated of practical operation.The complicated of this operation also will very easily be brought out the generation of position error, and this all will reduce the repeatability of experiment greatly.

In addition, each single channel TMS coil needs special control unit in the such scheme, and multichannel must cause the complicated of control unit, and will strengthen cost.

At last, also be the most important, namely above-mentioned TMS coil design scheme all can't realize the dynamically changeable of stimulus type.Thereby above-mentioned design all is to have adopted the arrangement of o shape coil to form the multi-channel coil array.In actual TMS use procedure, usually wish to select according to actual needs different stimulation areas and stimulate kind (o shape or 8-shaped).And the dimensions of above-mentioned TMS coil design scheme coil is and immobilizes, and coil-type is fixed as o shape coil, and this is so that stimulate area and kind all can't realize according to demand dynamic change.

In sum, the existing multichannel TMS coil design scheme shown in Fig. 2 exist all that resolution is low, coil location is difficult, control unit mainly with and the problems such as difficult accommodation of system.This becomes the immediate cause that causes in recent years multichannel TMS research to be stagnated.And implementing during TMS stimulates, at random change as required the dynamic research such as stimulation location, stimulation mode and stimulus intensity especially traditional method can't realize.This programme will propose a kind of novel dynamically changeable multichannel TMS coil array design for this present situation.

The utility model content

The purpose of this utility model is to provide a kind of brand-new full head dummy dynamically changeable multichannel TMS coil array method for designing and control technology, utilize the novel TMS coil array of this programme design, can produce simultaneously a plurality of TMS coils in complete scope, also can change stimulates size, intensity and stimulation mode (selecting o shape or 8-shaped).This coil array can realize that the TMS of multichannel high spatial resolution stimulates, and can realize the dynamically changeable of stimulation sites and mode.

The technical solution that realizes this utility model purpose is: a kind of dynamically changeable multichannel transcranial magnetic stimulation coil array, this coil array comprise the one group of equally spaced straight line insulated copper of S direction wire, one group of C direction equally spaced straight line insulated copper wire and control unit; S direction and C direction correspond respectively to sagittal axis and the frontal axis of brain, two groups of mutual square crossings of wire and the formation reticulated coil array insulated from each other of S direction and C direction, and the input of every rectilinear wire or outfan all connect an independently control unit; This coil array spatially bends to sphere, and the sphere radian meets human body head curve form, and whole coil array is helmet shape and covers complete scope.Described control unit is used for the closure state of pilot, inflow or outflow direction and the current intensity of electric current.Do not have the interval between the TMS coil and be the array-like close-packed arrays.

This utility model compared with prior art, its remarkable advantage: the utility model proposes brand-new high-resolution dynamically changeable multichannel TMS coil array method for designing.The TMS coil of comparing traditional, the TMS coil array that goes out based on this Design Theory has following characteristics and advantage:

(1) can realize the real-time transmutability of kind, specification and size, position, quantity and the stimulus intensity of TMS coil:

By the control to the wire switch, can be by the TMS coil being varied to o shape or 8-shaped to change stimulation mode; By the control to access ampere wires interval, can produce the TMS coil of different size and size; By the control to access ampere wires position, can produce the TMS coil in the position of appointment; By the control to access ampere wires quantity, can produce the TMS coil of varying number; By the control to current intensity in the wire, can change TMS and stimulate size; The variation of above-mentioned stimulus parameter all can realize real-time control, can guarantee the real-time transmutability of stimulus parameter.

(2) can provide high spatial resolution to stimulate

With respect to arranging that on the head surface a plurality of single channel conventional coil consist of the traditional design scheme of multichannel TMS coil, this programme can realize that the close-packed array formula of distance distributes continuously, can farthest reduce the distance between the TMS coil, this provides possibility for providing high spatial resolution TMS to stimulate.

(3) can guarantee the accurate location of multi-channel coil position

Because whole coil array can accurately be located with respect to the position of head, and the relative position between each TMS coil is changeless, so can be simply and control exactly each TMS coil and head and the relative position between each TMS coil.This is as the criterion and determines that each TMS coil position of position provides guarantee.

(4) Stimulation of The Brain is neural more effectively

What be different from that o shape coil and figure-eight coil produce in the traditional design is that circular induced current distributes, and the TMS coil is square in this programme, can produce square induced current at intracranial and distribute.As previously mentioned, if induced current parallels with nerve fiber, thereby can induce stronger transmembrane potential to cause that neuronal cell is movable.Distribute because the cerebral nerve fiber is cocurrent and parallel more, traditional circular induced current of therefore comparing distributes, and square induced current distributes obviously can excite the activity of greater number nerve fiber, thereby Stimulation of The Brain is neural more effectively.

(5) can produce the stimulation of complicated type

Be different from traditional TMS coil design scheme and can only produce o shape or figure-eight coil.In this programme, except generating o shape and figure-eight coil, can also generate the TMS coil of complicated types such as isosceles triangle, 88 shapes and cross.

(6) can greatly reduce control unit

For the coil array of as shown in Figure 4 NxN, if adopt this traditional design thinking of simple arrangement of single channel TMS coil, need NxN control unit; And the mentality of designing of employing this programme then only needs the individual control unit of 2 (N+1).This has greatly simplified the complexity of control unit, and saving is controlled cost.

Description of drawings

Accompanying drawing 1 is TMS schematic diagram and traditional o shape or 8-shaped TMS coil, and (a) TMS stimulates schematic diagram (b) o shape coil and figure-eight coil schematic diagram.

Accompanying drawing 2 is existing multichannel TMS coil design scheme.(a) J. Ruohonen research group design (b) SL. Ho research group design (c) BY. Han research group design (d) XM. Wang research group design (e) CH. Im research group design (f) GZ. Xu research group design.

The TMS coil array design diagram that accompanyingdrawing 3 proposes for this programme.

The TMS coil array schematic diagram that accompanying drawing 4 proposes for this programme.

Accompanying drawing 5 is realized different size o shape coil schematic diagram for this programme; (a) small size o shape coil (b) large scale o shape coil.

Accompanying drawing 6 is realized different size figure-eight coil schematic diagram for this programme; (a) small size figure-eight coil (b) large scale figure-eight coil.

Accompanying drawing 7 is realized many sizes multichannel TMS coil schematic diagram for this programme; (a) many sizes of many sizes multichannel o shape coil (b) multichannel figure-eight coil.

Accompanying drawing 8 is realized isosceles triangle, 88 shapes and cross TMS coil schematic diagram for this programme.

Accompanyingdrawing 9 is realized many sizes multichannel polymorphic type TMS coil schematic diagram for this programme.

The analog computation result that accompanying drawing 10 designs for this programme; (a) the CURRENT DISTRIBUTION analog result of CURRENT DISTRIBUTION analog result (b) this programme figure-eight coil generation of this programme o shape coil generation.

The specific embodiment

The utility model proposes a kind of multichannel TMS coil array design that covers full head.This coil array is made of one group of S direction and the square crossing of the one group of equally spaced straight line insulated copper of C direction wire.S direction and C direction correspond respectively to sagittal axis and the frontal axis of brain.Two groups of wires intersect but formation reticulated coil array insulated from each other mutually in length and breadth.This coil array spatially bends to sphere, and its radian is designed to approach with human body head curved surface, and whole coil array is helmet shape and covers complete scope.

Every wire is by independently control unit control in the coil array, and control unit is then controlled by computer.Each control unit can pilot closure state, inflow or outflow and the current intensity of electric current.

The wire of energising can produce magnetic field around it, generation is perpendicular to the magnetic field of coil plane around wire thereby traditional TMS coil imports electric current in closing coil, and head generation induced current is run through in this magnetic field and final Stimulation of The Brain is neural.In this programme, by the control to the closure state of the electric current importing of every wire or derivation and wire, make the sense of current in the annular section that 2 wires of 2 wires of S direction and C direction consist of identical, namely be all clockwise or be all counterclockwise, the Electric Field Distribution of inducing that produces in the annular section that is then generated by these 4 wires insulated from each other is equal to the Electric Field Distribution of inducing that square closed loop produces.Although o shape induces Electric Field Distribution and the square Electric Field Distribution of inducing different in shape, does not have difference for this essence of ring-type induced current, therefore, the square coil that this programme adopts can be realized traditional o shape coil function.

Form because figure-eight coil is the o shape coil by 2 adjacent current opposite in direction, by the control to the sense of current of each wire, this programme can generate the closed loop of 2 adjacent one another are and current opposite in direction in coil array.Therefore, this programme can be realized the function of traditional figure-eight coil equally.

By the control to the sense of current of each wire, can be controlled at kind, specification and the size, position, the quantity that consist of the TMS coil in the coil array.By the control to the current intensity of each wire, can control the intensity that the TMS of generation stimulates.Because the parameter of control unit can real time altering, but the equal real time altering of kind, specification and size, position, quantity and the stimulus intensity of the TMS coil that produces in the coil array.Therefore, this programme can produce multichannel dynamically changeable TMS stimulates.

In addition, because whole coil array is net distribution, does not have distance between the adjacent windings and do not have the space, this is so that this programme can produce the higher TMS coil array of spatial resolution.In addition because the spacing of wire, the parameters such as radical of wire are fixed values, inner each TMS coil that produces of coil array with respect to the position of whole coil array also be clear and definite as can be known, this is so that convenient feasible to the location of multichannel TMS coil.In actual use, need not multichannel TMS coil is located one by one, only need whole coil array is located at head, can the disposable location work of finishing multichannel TMS coil.Therefore, this programme can be realized high-resolution multichannel TMS coil, can guarantee accuracy and the convenience of TMS coil location simultaneously.

Below in conjunction with accompanying drawing this utility model is described further.

The utility model proposes helmet-type multichannel TMS coil array design as shown in Figure 3.This coil array is by the one group of equally spaced straight line insulated copper of S direction wire, and one group of C direction equally spaced straight line insulated copper wire and control unit consist of.S direction and C direction correspond respectively to sagittal axis and the frontal axis of brain, two groups of mutual square crossings of wire and the formation reticulated coil array insulated from each other of S direction and C direction, and the input of every rectilinear wire or outfan all connect an independently control unit.This coil array spatially bends to sphere, and the sphere radian meets human body head curve form, and whole coil array is helmet shape and covers complete scope.

As shown in Figure 4, this coil array is made of one group of S direction and one group of equally spaced rectilinear wire square crossing of C direction.S direction and C direction correspond respectively to sagittal axis and the frontal axis of brain.The wire of S direction and C direction mutually intersects but insulate.Every wire is all controlled respectively importing, derivation or the closed condition of this wire by control unit independently, thereby control unit can be controlled the TMS stimulus intensity that current intensity control produces simultaneously.Each control unit is then controlled respectively by computer.

As shown in Figure 5, by changing the sense of current of each wire, can in coil array, produce o shape coil.Such as Fig. 5. (a), when electric current flows into from wire S3, C5 respectively, and in the situation about flowing out from S4, C6, just thereby can form closed loop in coil array produces undersized o shape coil.And such as Fig. 5. (b), flow into from wire S3, C3 respectively when controlling electric current, and in the situation of S7, C7 outflow, just thereby can form closed loop in coil array produces large-sized o shape coil.

As shown in Figure 6, by changing the sense of current of each wire, can in coil array, produce figure-eight coil.Such as Fig. 6. (a), when electric current flows into from wire S3, S5, C4, C6 respectively, and in the situation about flowing out from S4, C5, just flow to opposite closed loop can forming two, thus undersized figure-eight coil produced.And such as Fig. 6. (b), when electric current flows into from wire S2, S8, C2, C8 respectively, and in the situation about flowing out from S5, C5, just flow to opposite closed loop can forming two, thus large-sized figure-eight coil produced.

As shown in Figure 7, by changing the sense of current of each wire, can in coil array, produce many sizes multichannel o shape coil.Such as Fig. 7. (a), when electric current flows into from wire S2, C7 respectively, and in the situation about flowing out from S3, C8, just can produce in the coil array upper left corner undersized o shape coil.And flow into from wire S4, C2 respectively when controlling electric current, and in the situation of S8, C6 outflow, just can produce in the coil array lower right corner large-sized o shape coil.Such as Fig. 7. (b), when electric current flows into from wire S1, S3, C7, C9 respectively, and in the situation about flowing out from S2, C8, just can produce in the coil array upper left corner undersized figure-eight coil.And flow into from wire S3, S9, C1, C7 respectively when controlling electric current, and in the situation of S6, C4 outflow, just can produce in the coil array lower right corner large-sized figure-eight coil.

As shown in Figure 8, except traditional o shape and 8-shaped TMS coil, by changing the sense of current of each wire, can in coil array, produce the TMS coil of other type: when electric current flows into from wire S2, S4, C5, C7 respectively, and in the situation of S3, C6, C8 outflow, can realize isosceles triangle TMS coil in the upper left corner of coil array; When electric current flows into from wire S6, S8, C7, C9 respectively, and in the situation about flowing out from S7, S9, C6, C8, can realize 88 shape TMS coils in the upper right corner of coil array; When electric current flows into from wire S4, S6, C2, C4 respectively, and in the situation about flowing out from S3, S5, C1, C3, can realize cross TMS coil below in coil array.

As shown in Figure 9, by changing the sense of current of each wire, can in coil array, produce many sizes multichannel polymorphic type TMS coil.As shown in Figure 9, when electric current flows into from wire S2, S4, C7 respectively, and in the situation about flowing out from S3, C6, C8, just can on coil array is left, produce undersized figure-eight coil in the angle.When electric current flows into from wire S9, C7 respectively, and in the situation about flowing out from S6, C6, just can on coil array is right, produce prolate o shape coil in the angle.When electric current flows into from wire S4, S9, C1, C5 respectively, and in the situation about flowing out from S3, S6, C3, produce the long isosceles triangle coil of inequilateral below just can be in coil array.Therefore, by changing the sense of current, can in coil array, produce simultaneously different size, dissimilar a plurality of TMS coils.

As shown in figure 10, Figure 10. be that the o shape coil that this programme is produced that shows carries out the TMS induced current scattergram that the electromagnetic field simulation calculates (a).Such as Figure 10. (a), CURRENT DISTRIBUTION distributes in the form of a ring in o shape coil and reaches maximum in central authorities, meets the corresponding induced current of traditional o shape coil and distributes; Figure 10. be that what to show is that the figure-eight coil that this programme produces is carried out the TMS induced current scattergram that the electromagnetic field simulation calculates (b).Such as Figure 10. (b), CURRENT DISTRIBUTION distributes in the form of a ring in adjacent 2 o shape coils in figure-eight coil and reaches maximum in the junction, meets the corresponding induced current of traditional figure-eight coil and distributes.Can find that based on analog result the design of this programme proposition satisfies the design objective of coil, so this programme has good feasibility.

Claims (4)

1. dynamically changeable multichannel transcranial magnetic stimulation coil array is characterized in that: this coil array comprises one group of equally spaced rectilinear wire of S direction, one group of equally spaced rectilinear wire of C direction and control unit; S direction and C direction correspond respectively to sagittal axis and the frontal axis of brain, two groups of mutual square crossings of wire and the formation reticulated coil array insulated from each other of S direction and C direction, and the input of every rectilinear wire or outfan all connect an independently control unit; This coil array spatially bends to sphere, and the sphere radian meets human body head curve form, and whole coil array is helmet shape and covers complete scope.

2. dynamically changeable multichannel transcranial magnetic stimulation coil array according to claim 1 is characterized in that: described control unit be used for pilot closure state, electric current inflow or flow out direction and current intensity.

3. dynamically changeable multichannel transcranial magnetic stimulation coil array according to claim 1, it is characterized in that: two groups of wires of described S direction and C direction are straight line insulated copper wire.

4. dynamically changeable multichannel transcranial magnetic stimulation coil array according to claim 1 is characterized in that: do not have the interval between the TMS coil and be the array-like close-packed arrays.

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