CN202078298U - Startle response testing device - Google Patents

Abstract

The utility model relates to a startle response testing device, which comprises a computer with analysis software installed, a controller and data acquirer combination set, a soundproof box, a speaker, a platform, a weight sensor and an animal holding cage. The speaker, the platform, the weight sensor and the animal holding cage are disposed inside the soundproof box. The animal holding cage is disposed on the platform, the weight sensor is arranged at the bottom of the animal holding cage, the speaker is connected with an output port of a controller and data acquirer combination set, the weight sensor is connected with an input port of the controller and data acquirer combination set, and the controller and data acquirer combination set is connected with the computer. Compared with the prior art, the startle response testing device has the advantages of capability of achieving simultaneous performing of experimental stimulation and signal acquisition, simple structure, high sensitivity, high acquired data accuracy and the like.

Description

A kind of shock reflection test device

Technical field

This utility model relates to a kind of test set, especially relates to a kind of shock reflection test device.

Background technology

Shock reflection is the proprietary term of field of biology, be mammal reply accident stimulus or when running into dangerous situation spontaneous a kind of hedging protective reaction be a kind of simple behavior reaction, have important biological significance.Be mainly used in the laboratory of scientific research fields such as psychology, pharmacology, neurobiology, physiology and the research that the sensory gating afunction detects in institute now.Sensory gating is the regulating power of animal and human's brain to the input of sensory stimuli information, it is one of normal function of brain, and the sensory gating afunction is schizoid key character, whether the shock reflection normally is the important judge index whether the sensory gating function lacks, so the test of shock reflection index judgement and the treatment to schizophrenia and anxiety neurosis had very important significance, shock reflection measurement system is exactly a cover holonomic system of testing at the shock reflection index of laboratory animal, main object of study is laboratory animal (rat/mouse), can be used for detecting relevant schizophrenia drug in the experimental animal model drug effect.

In the world researching and analysing as far back as the sixties in 19th century of laboratory animal shock reflection just begun, research to the shock reflection mainly is the influence of the change of environment to the ANIMAL PSYCHE behavior change at first, entered for 20th century, along with going deep into of biomedical sector research, the research that shock is reflected has expanded to a plurality of subjects such as psychology, pharmacology, neurobiology, physiology.Along with the rise to integral animal behavioral study tide, various technology are applied to this field, from initial subjective qualitative observation, quantitative analysis up till now; Determine present computer-assisted analysis from initial artificial counting and human eye.

But the most products that occur all can only provide sonic stimulation at present, come the evaluation experimental result with the method for manually observing scoring then, can introduce huge artificial and error like this, cause the result inaccurate, and waste time and energy, can't carry out large batch of experiment, and very complicated on the structure, environmental stimulus system and signal acquiring system can't carry out reasonable integration.

The utility model content

The purpose of this utility model is exactly to provide a kind of for the defective that overcomes above-mentioned prior art existence can realize that experiment stimulates and signals collecting is carried out simultaneously, and apparatus structure is simple, highly sensitive, the high shock reflection test device of data accuracy rate of collection.

The purpose of this utility model can be achieved through the following technical solutions: a kind of shock reflection test device, it is characterized in that, this device comprises the computer that analysis software is housed, controller and data acquisition unit unit mahine, sound proof box, speaker, platform, weight sensor, animal is cage fixedly, described speaker, platform, weight sensor, animal fixedly cage is arranged in the sound proof box, described animal fixedly cage is arranged on the platform, the described animal fixedly bottom of cage is provided with weight sensor, described speaker is connected with the output port of controller and data acquisition unit unit mahine, described weight sensor is connected with the input port of controller and data acquisition unit unit mahine, and described controller and data acquisition unit unit mahine are connected with computer.

Described speaker is set in place on the speaker fixed mount in sound proof box, and the left and right sides of described platform is respectively equipped with a speaker.

This device also comprises the electricity irritation barrier board, and this electricity irritation barrier board is arranged on animal fixedly between cage, the weight sensor, and described electricity irritation barrier board is connected with another output port of controller and data acquisition unit unit mahine.

This device also comprises bulb, and this bulb is connected with an output port of controller and data acquisition unit unit mahine.

This device also comprises gas cylinder, gas pressure reducer, gas valve, gas outlet, described gas cylinder, gas pressure reducer, gas valve, gas outlet are in turn connected to form an air supply channel, described gas valve is connected with an output port of controller and data acquisition unit unit mahine, and described gas outlet is arranged on fixedly cage side of animal.

Compared with prior art, technology such as the pressure sensitive technology of this utility model application of advanced, electromechanical integration, gather the behavior signal of laboratory animal, analysis software is calculated according to behavior signal automatic analyser and is drawn behavior track and the feature of animal, automatically reduce a plurality of experiment parameters, for experiment is given information; In addition, this utility model also has the following advantages:

1, initiative environmental stimulus structurally directly is assembled acousto-optic electricity and environment control (system noise decay, sound insulation system) with signal acquiring system, has solved the shortcoming that existing experiment stimulation and signals collecting can't be carried out simultaneously;

2, apparatus structure is simple, highly sensitive, and the data accuracy rate of collection is compared with the data of using the conventional art collection and is greatly improved.

Description of drawings

Fig. 1 is a structural representation of the present utility model.

Among the figure 1 for computer that analysis software is housed, 2 for controller and data acquisition unit unit mahine, 3 for animal fixedly cage, 4 for platform, 5 for weight sensor, 6 for the electricity irritation barrier board, 7 for speaker, 8 for sound proof box, 9 for the speaker fixed mount, 10 for gas valve, 11 for bulb, 12 for gas piping, 13 be that gas pressure reducer, 14 is a gas cylinder.

The specific embodiment

Below in conjunction with the drawings and specific embodiments this utility model is elaborated.

Embodiment

As shown in Figure 1, a kind of shock reflection test device, this device comprise fixedlycage 3 of computer 1, controller and data acquisition unit unit mahine 2 that analysis software is housed,sound proof box 8, speaker 7,platform 4,weight sensor 5, animal.Controller and data acquisition unit unit mahine 2 can be controlled acousto-optic is electric.Speaker 7,platform 4,weight sensor 5, animal fixedlycage 3 are arranged in the sound proof box 8.Animal fixedlycage 3 is arranged on the platform 4.The animal fixedly bottom ofcage 3 is provided with weight sensor 5.Speaker 7 is connected with the output port of controller and data acquisition unit unit mahine 2.Speaker 7 is set in place on the speaker fixedmount 9 insound proof box 8, and the left and right sides ofplatform 4 is respectively equipped with a speaker 7.Weight sensor 5 is connected with the input port of controller and data acquisition unit unit mahine 2.Controller and data acquisition unit unit mahine 2 are connected with computer 1.This device also comprises electricityirritation barrier board 6, and this electricityirritation barrier board 6 is arranged on animal fixedly betweencage 3, theweight sensor 5, and electricityirritation barrier board 6 is connected with another output port of controller and data acquisition unit unit mahine 2.This device also comprisesbulb 11, and thisbulb 11 is connected with an output port of controller and data acquisition unit unit mahine 2.This device also comprisesgas cylinder 14,gas pressure reducer 13,gas valve 10, gas outlet,gas cylinder 14,gas pressure reducer 13,gas valve 10, gas outlet are connected to form an air supply channel bygas piping 12 successively, andgas valve 10 is connected with an output port of controller and data acquisition unit unit mahine 2.Gas outlet is arranged on fixedlycage 3 sides of animal.

Implement example:

Laboratory animal is put into fixedly cage of animal, and cage can limit its motion, but unfixing.Then cage is placed on the platform, make laboratory animal undisturbedly adapt to 5min.

Sonic stimulation is made up of the burst noise of 98dB and 120dB (continuing 20ms).Each stimulates when producing, and measures the reaction of laboratory animal in the 200ms.

By the somatic movement of pressure sensitive determination experiment animal in cage, be weight change through digital-to-analogue conversion, the computer-automatic collection record data.Stimulate the maximum weight of back 200ms to be changed to the shock peak value, same stimulation repeats 12 times and draws average peak.An experiment comprises that each stimulus intensity repeats 12 times at random at interval, and stimulus intervals is 20～40s (occurring at random).The experiment before measurement is value in contrast once, and the measured value of result after with administration accounts for the percentage ratio that is worth before the administration and represent.

The example explanation:

(this example only relates to sonic stimulation to this example, do not relate to stimulations such as light, electricity, gas) realization require in upper computer software, to be provided with the parameters such as size, stimulation time and interval of sonic stimulation, and control controller and data acquisition unit unit mahine stimulate according to the flow process output that sets, the weight sensor acquisition and recording stimulates the signal that the health of laboratory animal in the 200ms of back changes then, conduct back in the data acquisition controller, repeated transmission returns and carries out corresponding analysis in the upper computer software, finally draws needed experimental result.

Claims (5)

1. one kind shocks reflection test device, it is characterized in that, this device comprises the computer that analysis software is housed, controller and data acquisition unit unit mahine, sound proof box, speaker, platform, weight sensor, animal is cage fixedly, described speaker, platform, weight sensor, animal fixedly cage is arranged in the sound proof box, described animal fixedly cage is arranged on the platform, the described animal fixedly bottom of cage is provided with weight sensor, described speaker is connected with the output port of controller and data acquisition unit unit mahine, described weight sensor is connected with the input port of controller and data acquisition unit unit mahine, and described controller and data acquisition unit unit mahine are connected with computer.

2. a kind of shock reflection test device according to claim 1 is characterized in that, described speaker is set in place on the speaker fixed mount in sound proof box, and the left and right sides of described platform is respectively equipped with a speaker.

3. a kind of shock reflection test device according to claim 1, it is characterized in that, this device also comprises the electricity irritation barrier board, this electricity irritation barrier board is arranged on animal fixedly between cage, the weight sensor, and described electricity irritation barrier board is connected with another output port of controller and data acquisition unit unit mahine.

4. a kind of shock reflection test device according to claim 1 is characterized in that this device also comprises bulb, and this bulb is connected with an output port of controller and data acquisition unit unit mahine.

5. a kind of shock reflection test device according to claim 1, it is characterized in that, this device also comprises gas cylinder, gas pressure reducer, gas valve, gas outlet, described gas cylinder, gas pressure reducer, gas valve, gas outlet are in turn connected to form an air supply channel, described gas valve is connected with an output port of controller and data acquisition unit unit mahine, and described gas outlet is arranged on fixedly cage side of animal.

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