CN201871104U - Microdialysis probe percutaneous puncture directional implanter and microdialysis probe thereof - Google Patents

Abstract

The utility model provides a microdialysis probe percutaneous puncture directional implanter and a microdialysis probe thereof, which are applied to the field of sampling of directional puncture microdialysis of deep organs. The microdialysis probe percutaneous puncture directional implanter comprises a percutaneous directional puncture guide needle and a microdialysis probe mated with the guide needle, wherein the microdialysis probe is Y-shaped and consists of a dialysis membrane, a liquid inlet pipe, a liquid outlet pipe and a metal mark; the liquid inlet pipe and the liquid outlet pipe are arranged side by side as a whole in vivo; and the lower ends of the in-vivo side-by-side sections of the liquid inlet pipe and the liquid outlet pipe are connected with the dialysis membrane side by side which separates the liquid inlet pipe and the liquid outlet pipe. The utility model has the advantages of being simple in structure, convenient to use, accurate in positioning and convenient for detection, causing less hurt on an organism, and the like; and obtained samples better meet practical pathological and physiological status, thus being beneficial to analysis research and diagnosis treatment.

Description

Directed embedded device of microdialysis probe percutaneous puncture and microdialysis probe thereof

Technical field

This utility model relates to technical field of medical instruments, is specifically related to a kind of line style microdialysis probe and directed embedded device of microdialysis probe percutaneous puncture of improvement.

Background technology

Microdialysis (microdialysis) technology is from a kind of micro-biochemistry detection technique at body that last century, the eighties grew up, and now extensively applies to a plurality of fields such as pharmacokinetics, neurobiochemistry.Micro-dialysis device is so that small-molecule substance can macromolecular substances can not be a kind of biological living sampling device of principle design through dialyzer through half dialyzer also spreads along Concentraton gradient, and the line style probe of sampling reaches the quartz or the plastic capillary that link to each other with its two ends by the capillary type dialyzer usually and constitutes.

Dialyzer zone with probe during detection is embedded in the tissue to be measured, and the two ends of probe are stretched out external, and an end links to each other with micro-injection pump perfusate is continued to inject probe, and the other end is then exported dialysis solution and is used for detecting.Because target substance can diffuse into perfusate and reach dynamic equilibrium along concentration difference through dialyzer in organizing, so, get final product the level and the variation thereof of target substance in the liquid outside research organization's inner cell by measuring the concentration of determinand in the output liquid.The microdialysis technology almost can be used in all organ of body and tissue at present, comprises deep internal organs such as the heart, liver, lung.But, the prerequisite that the microdialysis technology will reach accurate sampling is that probe must accurately place target region.Method in common is that surgical operation dissection direct-view is embedded in the target area with probe down at present, and this method is that the service manual of commercially available each company's probe is introduced, and also is the method that numerous bibliographical information adopted.

But, undoubtedly the operation implantation mode is traumatic big, complicated operation, need open splanchnocoel when especially probe is imbedded deep such as lungs, liver organ, occur pneumothorax, complication such as hemorrhage easily, the lighter influences the accuracy of testing result, and weight person jeopardizes life, cause the zoopery success rate not high, monitoring exists the problem aspect all ethics especially on human body.So can invent a kind of safe and effective and success rate is high, complication is little microdialysis probe deep internal organs method for posting, it be significant just to seem.Based on this, the applicant has applied for that on August 31st, 2006 a kind of microdialysis probe percutaneous by name implants the utility model patent of stereotactic puncture guide pin, and its patent No. is utility model ZL200620045344.5, and convenient and wound reduces to some extent than the routine operation method.

But in the practice more than 4 years, the applicant finds to remain in several point defects, mainly be that guide pin cooperates and to insert existing commercially available line style microdialysis probe and certainly will penetrate whole destination organization, path length in the body, the risk of penetration damage increases, and the line style probe that separates of two ends locatees difficultly in the body of deep, occurs the inaccurate of sampling easily.

The utility model content

At above-mentioned defective, the improvement line style microdialysis probe that the purpose of this utility model provides the directed embedded device of a kind of microdialysis probe percutaneous puncture and matches, the risk of penetration damage and solve probe accurate technical problem such as location in vivo when inserting with further attenuating microdialysis probe.

For achieving the above object, this utility model has adopted following technical scheme:

The directed embedded device of a kind of microdialysis probe percutaneous puncture is applied to organ stereotactic puncture microdialysis field, deep, comprises percutaneous stereotactic puncture guide pin and microdialysis probe.It is characterized in that, described microdialysis probe is Y-shaped, comprise dialyzer, feed tube, drain pipe and metal marker, be one side by side in described feed tube and the fluid body, in described feed tube and the fluid body side by side a section lower end is connected dialyzer, the dialyzer that described feed tube and drain pipe are connected side by side is with feed tube and drain pipe separation.

According to the directed embedded device of the described microdialysis probe percutaneous puncture of this utility model preferred embodiment, the junction of described dialyzer and drain pipe is provided with metal marker.

According to the directed embedded device of the described microdialysis probe percutaneous puncture of this utility model preferred embodiment, described feed tube and drain pipe are provided with scale.

According to the directed embedded device of the described microdialysis probe percutaneous puncture of this utility model preferred embodiment, described dialyzer is a polycarbonate membrane.

According to the directed embedded device of the described microdialysis probe percutaneous puncture of this utility model preferred embodiment, described feed tube and drain pipe are quartz capillary, and outer wall is provided with the polyimides protective layer.

According to the directed embedded device of the described microdialysis probe percutaneous puncture of this utility model preferred embodiment, described percutaneous stereotactic puncture guide pin further comprises: stylophore and nook closing member, described stylophore further comprises needle stand and needle tubing, described needle stand hollow, and end is provided with a groove; Described nook closing member further comprises needle core base, needle body and needle point, described needle body front end is a needle point, tail end is connected with needle core base, described needle body external diameter and length and described needle tubing internal diameter and length are complementary, described needle core base profile and described stylophore needle stand inner space are complementary, and be provided with and the corresponding projection of described needle stand groove, be used for needle core base and needle stand chimeric.

According to the directed embedded device of the described microdialysis probe percutaneous puncture of this utility model preferred embodiment, described needle tubing and needle body are provided with corresponding scale.

This utility model provides a kind of microdialysis probe again, described microdialysis probe is Y-shaped, comprise dialyzer, feed tube, drain pipe and metal marker, be one side by side in described feed tube and the fluid body, in described feed tube and the fluid body side by side a section lower end is connected dialyzer, the dialyzer that described feed tube and drain pipe are connected side by side is with feed tube and drain pipe separation.

According to the described microdialysis probe of this utility model preferred embodiment, the junction of described dialyzer and drain pipe is provided with metal marker.

According to the described microdialysis probe of this utility model preferred embodiment, described feed tube and drain pipe are provided with scale.

Owing to adopted above technical characterictic, make this utility model than prior art, have following advantage and good effect:

First, this utility model will have the line style probe that commercially available two ends separate now and change the Y shape probe that an end is the dialyzer section into, the dialyzer section is positioned at the cecum of Y shape hypomere, be the U shape, connect side by side feed tube and drain pipe, be that perfusate becomes dialysis solution, external micro pump and the sampler of separately connecting separately again of feed tube side by side and drain pipe after cecum U type refluxes.Only need during use guide pin is punctured into the deep destination organization, inserting probe then gets final product, avoided to sampling is forced to important organs such as lungs " to wearing " with outside the drain pipe lead body that will have the line style probe now, thereby shortened puncture path, further lowered the incidence rate of wound.Because the liquid-in pipe that goes out of Y shape probe all draws from a skin penetrating mouth, be beneficial on body surface and fix in addition, convenient long-time living body sampling.

Second, labelling is carried out with metals such as Nitinols in the dialyzer and the drain pipe junction of the line style microdialysis probe of improvement, is beneficial to accurate location when percutaneous is inserted on the one hand, also convenient check after inserting on the other hand, judge that whether probe is shifted, and has reduced the inaccuracy of sampling between tissue.

The 3rd, percutaneous stereotactic puncture guide pin described in the utility model is the patent guide pin that obtains previously

(ZL200620045344.5) change part is that the stylophore of outside and intermediary needle tubing are united two into one, and existing design is made up of stylophore and nook closing member, and Comparatively speaking, the puncture guide pin function after the improvement is the same, but has reduced parts, more convenient practicality.

The 4th, this utility model is reference mark on the stereotactic puncture guide pin not only, also increases scale on the line style probe, can be according to actual needs, judge in feed tube and the fluid body different length of section side by side as animal build size and the site of puncture depth, the carrying out of convenient location and puncture and sampling.

Certainly, realize any one preferred embodiment of this utility model content, might not reach above whole technique effect simultaneously.

Description of drawings

Fig. 1 is the structural representation of percutaneous stereotactic puncture guide pin of the present utility model;

Fig. 2 is the stylophore structure chart among Fig. 1;

Fig. 3 is the nook closing member structure chart among Fig. 1;

Fig. 4 A is the needle stand sketch map among Fig. 2;

Fig. 4 B is the needle core base sketch map among Fig. 3;

Fig. 5 is the sketch map of Y shape line style microdialysis probe of the present utility model;

Fig. 6 is the blind section generalized section in Y shape lower end among Fig. 5.

The specific embodiment

Below in conjunction with accompanying drawing,, do being described in further detail to preferred embodiment of the present utility model.

The directed embedded device of a kind of microdialysis probe percutaneous puncture, be applied to organ stereotactic puncture microdialysis sampling field, deep, comprise percutaneous stereotactic puncture guide pin and supporting microdialysis probe, described puncture guide pin punctures accurately to the body destination organization, and supporting microdialysis probe of inserting then directly carries out the sampling of target area.

Please refer to Fig. 1-Fig. 4 B, percutaneous stereotactic puncture guide pin is made up ofstylophore 1 and nook closing member 2.Stylophore 1 is made up of needle stand 1.1 and needle tubing 1.2, and the external diameter of needle tubing 1.2 internal diameters and nook closing member 2 is complementary, and needle tubing 1.2 is provided with scale 1.2.1.

Needle stand 1.1 holds the usefulness that punctures for user, hollow, and end is provided with a groove 1.1.1, the effect of the existing prompting pinpoint inclined plane of this groove 1.1.1 direction, fixing nook closing member 2 again.

Nook closing member 2 is made up of needle core base 2.1, needle body 2.2 and needle point 2.3, needle body 2.2 front ends are needle point 2.3, rear end and needle core base 2.1 join, needle body 2.2 is provided with scale 2.2.1, this scale 2.2.1 is corresponding with the scale 1.2.1 on the needle tubing 1.2, and the internal diameter and the length of needle body 2.2 external diameters and length and needle tubing 1.2 are complementary.

The profile of needle core base 2.1 and size are complementary with the interior spatial structure of the needle stand 1.1 ofstylophore 1, and it has a protruding 2.1.1 can be embedded in the groove 1.1.1 of needle stand 1.1.

Preferred embodiment is, percutaneous stereotactic punctureguide pin stylophore 1 is a flexible plastic sleeve, and wherein needle tubing 1.2 external diameters are 0.6 millimeter, and long 18 centimetres, the back connects needle stand 1.1, last indexing 1.2.1; Nook closing member 2 is a metal needle, and wherein needle body 2.2 is long 18 centimetres, and its high scale 2.2.1 and needle tubing 1.2 high scale 1.2.1 match, and diameter is 0.018 inch, preceding connection needle point 2.3, after connect needle core base 2.1; Needle point 2.3 is the inclined-plane, and long 1.5 centimetres, groove angle is 30 degree.

Please refer to Fig. 5-Fig. 6, supporting improvement Y shape line style microdialysis probe comprisesdialyzer 3,feed tube 4,drain pipe 5 andmetal marker 6;Feed tube 4 anddrain pipe 5 are marked with scale, separate separately earlier, constitute the last two ends of Y shape, afterfeed tube 4 anddrain pipe 5 are one side by side in vivo, form the hypomere of Y shape,feed tube 4 is connected thedialyzer 3 thatfeed tube 4 anddrain pipe 5 are separated withdrain pipe 5 end side by side;Dialyzer 3 is the major function district, is positioned at the cecum of Y shape hypomere, connectsfeed tube 4 before it, after connectdrain pipe 5;Metal marker 6 is positioned at the junction ofdialyzer 3 anddrain pipe 5.

Preferred embodiment is, the length overall of line style microdialysis probe is 101 centimetres, anddialyzer 3 materials are Merlon, and length is 10 millimeters, 320 microns of internal diameters, molecular weight 20000 dalton of damming; There is themetal marker point 6 of a Nitinol junction ofdialyzer 3 anddrain pipe 5;Feed tube 4 is side by side made by the identical quartz capillary of caliber withdrain pipe 5, and the pipe outer wall scribbles the polyimides protective layer, 20 centimetres of length side by side in the body, and 200 microns of internal diameters, the length that two ends separate on the Y shape respectively is 40 centimetres.

Certainly, puncture guide pin of the present utility model and line style probe all can be made different specifications according to actual needs.

Following simple declaration use, earlier percutaneous stereotactic puncture guide pin nook closing member is inserted stylophore, the nook closing member scale aligns one by one with the scale of stylophore, needle point is exposed to outside the stylophore, the projection of needle core base embeds in the groove of needle stand, circuit inserting needle according to prior location and design, the percutaneous puncture guide pin accurately enters body inner target tissue district under image documentation equipment monitors, after fixing stylophore nook closing member is slowly withdrawed from, select the improvement Y shape line style microdialysis probe of appropriate length then, the Y end is inserted stylophore, make the cecum of probe and dialyzer section be positioned at destination organization according to scale, stationary probe withdraws from stylophore gently, the metal marker that iconography is checked visible probe is arranged in target region, and the skin external fixation can connect microdialysis pump etc. routinely and take a sample.

In sum, this utility model adopts the line style microdialysis probe of Y shape structure, the softness that had both kept line style, made full use of the cecum of Y shape probe again, be used with improved percutaneous stereotactic puncture guide pin, have simple in structure, easy to use, accurate positioning, be convenient to detect and the further advantages such as minimizings of body injury, the more realistic pathological and physiological condition of institute's sample thief helps analyzing and researching and diagnoses and treatment.

More than disclosed only be preferred embodiment of the present utility model; and be not to be used for limiting itself, any those of ordinary skill in the art are under the situation of this utility model essence spirit intension; the equalization of being done changes and changes, and all should drop in the protection domain of the present utility model.

Claims (10)

Translated fromChinese

1.一种微透析探针经皮穿刺定向置入装置，应用于深部器官定向穿刺微透析领域，包括经皮定向穿刺导针和微透析探针。其特征在于，所述微透析探针呈Y形，包括透析膜、进液管、出液管和金属标记，所述进液管和出液管体内并排为一体，所述进液管和出液管体内并排段下端连接透析膜，所述进液管和出液管并排连接的透析膜将进液管和出液管分隔。1. A percutaneous puncture directional insertion device for a microdialysis probe, which is applied to the field of deep organ directional puncture microdialysis, comprising a percutaneous directional puncture guide needle and a microdialysis probe. It is characterized in that the microdialysis probe is Y-shaped and includes a dialysis membrane, a liquid inlet pipe, a liquid outlet pipe and a metal mark, and the liquid inlet pipe and the liquid outlet pipe are arranged side by side in one body, and the liquid inlet pipe and the liquid outlet pipe The lower end of the side-by-side section in the liquid pipe body is connected to the dialysis membrane, and the dialysis membrane connected side by side to the liquid inlet pipe and the liquid outlet pipe separates the liquid inlet pipe and the liquid outlet pipe.2.如权利要求1所述的微透析探针经皮穿刺定向置入装置，其特征在于，所述透析膜和出液管的连接处设置有金属标记。2. The microdialysis probe percutaneous puncture directional insertion device according to claim 1, characterized in that a metal marker is provided at the junction of the dialysis membrane and the outlet pipe.3.如权利要求1所述的微透析探针经皮穿刺定向置入装置，其特征在于，所述进液管和出液管上设置有刻度。3. The microdialysis probe percutaneous puncture directional implantation device according to claim 1, wherein a scale is arranged on the liquid inlet pipe and the liquid outlet pipe.4.如权利要求1所述的微透析探针经皮穿刺定向置入装置，其特征在于，所述透析膜为聚碳酸酯膜。4. The microdialysis probe percutaneous puncture directional implantation device according to claim 1, wherein the dialysis membrane is a polycarbonate membrane.5.如权利要求1所述的微透析探针经皮穿刺定向置入装置，其特征在于，所述进液管和出液管为石英毛细管，外壁设置有聚酰亚胺保护层。5. The microdialysis probe percutaneous puncture directional implantation device according to claim 1, wherein the liquid inlet pipe and the liquid outlet pipe are quartz capillaries, and the outer wall is provided with a polyimide protective layer.6.如权利要求1所述的微透析探针经皮穿刺定向置入装置，其特征在于，所述经皮定向穿刺导针进一步包括：针鞘和针芯，所述针鞘进一步包括针座和针管，所述针座中空，末端设置有一凹槽；所述针芯进一步包括针芯座、针体和针尖，所述针体前端为针尖，尾端与针芯座连接，所述针体外径和长度与所述针管内径和长度相匹配，所述针芯座外形与所述针鞘的针座内部空间相匹配，且设置有与所述针座凹槽对应的凸起，用于将针芯座和针座嵌合。6. The microdialysis probe percutaneous puncture directional insertion device according to claim 1, wherein the percutaneous directional puncture guide needle further comprises: a needle sheath and a needle core, and the needle sheath further comprises a needle seat and a needle tube, the needle seat is hollow, and a groove is provided at the end; the needle core further includes a needle core seat, a needle body and a needle point, the front end of the needle body is a needle point, and the tail end is connected with the needle core seat, and the outside of the needle body diameter and length match the inner diameter and length of the needle tube; The core seat and the needle seat are fitted.7.如权利要求6所述的微透析探针经皮穿刺定向置入装置，其特征在于，所述针管和针体上设置有对应的刻度。7. The microdialysis probe percutaneous puncture directional insertion device according to claim 6, characterized in that, the needle tube and the needle body are provided with corresponding scales.8.一种微透析探针，其特征在于，所述微透析探针呈Y形，包括透析膜、进液管、出液管和金属标记，所述进液管和出液管体内并排为一体，所述进液管和出液管体内并排段下端连接透析膜，所述进液管和出液管并排连接的透析膜将进液管和出液管分隔。8. A microdialysis probe, characterized in that, the microdialysis probe is Y-shaped, including a dialysis membrane, a liquid inlet pipe, a liquid outlet pipe and a metal marker, and the inside of the liquid inlet pipe and the liquid outlet pipe are arranged side by side as In one piece, the lower ends of the side-by-side sections of the liquid inlet pipe and the liquid outlet pipe are connected to the dialysis membrane, and the dialysis membrane connected side by side of the liquid inlet pipe and the liquid outlet pipe separates the liquid inlet pipe and the liquid outlet pipe.9.如权利要求8所述的微透析探针，其特征在于，所述透析膜和出液管的连接处设置有金属标记。9. The microdialysis probe according to claim 8, characterized in that metal markers are provided at the connection between the dialysis membrane and the outlet pipe.10.如权利要求8所述的微透析探针，其特征在于，所述进液管和出液管上设置有刻度。10 . The microdialysis probe according to claim 8 , wherein scales are arranged on the liquid inlet pipe and the liquid outlet pipe. 11 .

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