CN201049111Y - Propofol closed-loop target controlled infusion/injection automatic control device - Google Patents

Abstract

A propofol closed-loop target-controlled infusion automatic control device takes bispectral index (BIS) value as feedback index to complete automatic control of propofol anesthesia infusion speed and to adjust blood drug level and anesthetic action. The device comprises an electric source (3), an infusion actuator (1) and a control device (2), wherein, the control device consists of an electric source management module, a control module of the infusion actuator, a central control singlechip provided with a built-in control program, an electroencephalogram (EEG) monitoring module with EEG electrodes, a display device and an input device; the electric source realizes power supply for each device under the control of the electric source management module; the singlechip is in electrical connection with the electric source management module, the control module of the infusion actuator, the display device and the input device through data lines; the output signal of the EEG monitoring module is transmitted to the signal input end of the singlechip through a network interface. The utility model controls propofol blood drug level according to the changes of the BIS so as to control the depth of anesthesia; moreover, being simple and convenient for operation, the utility model operates automatically after different BIS values are set according to the progress of an operation; therefore, programmed intravenous anesthesia and sequential administration are realized to ensure the safety of a patient during an operation and avoid intraoperative awareness.

Description

Propofol closed-loop target controlled infusions automaton

Technical field

It serves as that the feedback index is controlled propofol anesthesia infusion velocity automatically with brain electricity bispectral index (BIS) value that this utility model relates to a kind of, and then regulates the infusion control device of blood drug level and anesthetic action.

Background technology

During intravenous anesthesia, all medicines all give through vein, and blood drug level is crossed low or too high may causing and known in patient's art or the anesthesia recovery delay.The depth monitoring of intravenous anesthesia, prediction and control are the problems that the clinical anesthesia doctor is paid close attention to always.Along with development of computer, according to the principle administration of pharmacokinetics, with the controlled by single chip microprocessor infusion pump, i.e. target controlled infusion (Target Controlled Infusion, TCI) can be based on pharmacokinetics and pharmacodynamics, by regulating drug target concentration control depth of anesthesia.

The intravenous anesthesia infusion is controlled, at first be after basic research such as the medicine generation of having passed through a large amount of intravenous anesthesia pharmacologys, the control of the intravenous anesthesia degree of depth, anesthetics commonly used, pharmacodynamics, the gained conclusion is become system control program to be write in the single-chip microcomputer internal processes memory block, program is selected by patient parameter setting and target control blood drug level, according to the required injection speed of pharmacokinetics Equation for Calculating, generate the motion that the corresponding control signals injection advances screw mandrel, promote the syringe of laying on the infusion actuator fixed mount of being furnished with the intravenous anesthesia medicinal liquid.Owing to be the universal law of from a large amount of practices, summing up, study, extracting, facts have proved the respond well of anesthesia infusion control.Further research and development direction can be sought and be established the pharmacodynamic index of reliable intravenous anesthetic sensitivity and develop corresponding feedback device to the reaction of certain anesthetics when anaesthetizing infusion according to each patient exactly.The feedback index that adopts has BIS value (brain electricity bispectral index at present, prevent to know in the art), HRVI (heart rate variability, prevent excessive stress) and blood pressure and heart rate etc., but still do not have definite and ideal single index at present, be impossible with all medicines of single control indexes.Therefore, seek the relevant pharmacodynamic index of different pharmaceutical and be used to feed back imperative.

Propofol is clinical intravenous anesthetic commonly used, because its effect compartment balancing speed is very fast, onset is rapid, and it is little to the influence of infusion time correlation half-life to continue medication for a long time, is usually used in the non-inpatient of outpatient service, pediatric anesthesia and induction of anesthesia, anesthesia and keeps etc.Brain electricity bispectral index (BIS) mainly reflects the phase place coupling between the EEG signal medium frequency, and the scope of changing the value of information that gets by Fourier (Fourier) is 0～100, mainly reflects corticocerebral excitement or inhibitory state.

Confirm clinically: the anesthetics propofol blood drug level and the BIS value that suppress brain essence are negative correlation, and the size of BIS value has dependency highly with calm consciousness, can be used for monitoring the calm composition of depth of anesthesia preferably.BIS is stable, directly perceived, and is better than other brain electricity indexs with propofol blood drug level dependency.

Usually, patient BIS value＞85% consciousness exists, 41～60% general anesthesia states, 10～49% is dark narcotism, this is just for by being connected with the intravenous anesthesia control device with BIS value, is developed into to anaesthetize closed feedback loop and control the propofol depth of anesthesia and created condition, and serve as to feed back index to control propofol automatically and anaesthetize infusion velocity with the BIS value, and then regulate blood drug level and anesthetic action, can make the anesthesia process safer, steady.

Summary of the invention

The purpose of this utility model, just provide a kind of possess intelligence, serve as to feed back control indexes propofol injection speed with the real-time brain of patient electricity bispectral index (BIS) value, and then control the propofol closed-loop target controlled infusions automaton of propofol blood drug level and sedation depth.

For realizing above-mentioned target, this propofol closed-loop target controlled infusions automaton, comprise power supply, infusion actuator and control device, control device is made of central control single chip computer, display device and the input equipment of power management module, the control module of infusion actuator, built-in control sequence, power supply is subjected to power management module control to each device power supply, and central control single chip computer has data wire to be electrically connected with control module, display device and the input equipment of power management module, infusion actuator respectively; It is characterized in that: described control device also comprises the brain electricity monitoring module of being with electrode for encephalograms, and its output signal is connected to the signal input part of central control single chip computer by network interface.

Described infusion actuator is the controlled syringe pump that propofol is housed; Or by controllable motor, turn-screw guide rail, be placed in the syringe that propofol is housed on the fixed mount and constitute, the output of controllable motor drives the turn-screw pushing syringe.

Described display device is a LCDs.

Described input equipment is keyboard or touch screen.

On the basis of the above, this utility model can be done following improvement:

Described infusion actuator also comprises infusion ultimate position pick off.

Described power supply also comprises backup battery, and it is connected with power management module by data wire.

The beneficial effects of the utility model are:

(1) because the BIS value is negative correlation with the anesthetics propofol that suppresses brain essence, the size of BIS value and calm consciousness height correlation, and BIS is stable, directly perceived, be better than other anesthesia depth monitoring indexs with propofol blood drug level dependency, patient's blood drug level and depth of anesthesia in the time of therefore can reflecting anesthesia exactly as the feedback index with BIS.

(2) acquisition of BIS value is an atraumatic, can not bring misery to patient.

(3) this utility model comprises the feedback closed loop loop, can according to real-time monitoring to patient's BIS value carry out only infusion control.

(4) of the present utility model easy and simple to handle, after the different BIS value of operation progress setting, can move automatically, can guarantee safety in patient's art, avoid knowing in the art.

This utility model can controlled on the blood drug level by patient parameter setting and target according to the universal law of summing up from a large amount of practices, studying, extract, further, with the real-time BIS of patient as the feedback index, also depth of anesthesia of patient's blood drug level when showing reflection, monitoring, control anesthesia more accurately.

Description of drawings

Accompanying drawing is a principle assumption diagram of the present utility model.

The specific embodiment

As shown in drawings, this propofol closed-loop target controlled infusions is controlled the embodiment of composite set automatically, compriseinfusion actuator 1,control device 2 andpower supply 3, the infusion actuator by controllable motor, turn-screw guide rail, be placed in syringe and position sensor that propofol is housed on the fixed mount and constitute, the output of controllable motor drives the turn-screw pushing syringe; Control device is made of central control single chip computer, LCDs and the finger-impu system of power management module, the motor drive module of infusion actuator, built-in control sequence, AC-DC Switching Power Supply and the backup battery of power supply for having control line to be connected with power management module respectively, power supply are powered to each device by power management module control; Central authorities' control single chip computer has data wire to be electrically connected with control module, position sensor, LCDs and the keyboard of power management module, infusion actuator respectively, the output control controllable motor of motor drive module, control device also includes brain electricity bispectral index analyser, it includes the electrode for encephalograms that can be placed in patient head, and the outfan of brain electricity bispectral index analyser is connected to the input of central control single chip computer by the networking interface.

Be placed in the electrode for encephalograms of patient's head, and will be input to as the BIS value of feedback index in the brain electricity bispectral index analyser, the outfan of brain electricity bispectral index analyser is connected to the input of central control single chip computer by the networking interface, central authorities' control single chip computer plug-in is the patient's BIS value at this moment and the BIS value of conduct feedback index relatively, by being benchmark with patient BIS, set different BIS values, as 41～60% general anesthesia states, 10～49% is dark narcotism, as perform the operation and finish to establish BIS value＞85%, and calculate according to program, send a control signal to the control module of infusion actuator, control module control rotating speed of motor also drives turn-screw, and the syringe that turn-screw promotes to be attached thereto carries out infusion to the patient.The BIS value with patient that circulation like this forms is the closed loop feedback control of feedback index, can control the infusion of anesthesia effectively, efficiently.

Infusion ultimate position pick off sends the central control single chip computer output alarm that signal is given control device after infused.

Claims (4)

1. propofol closed-loop target controlled infusions automaton, comprise power supply (3), infusion actuator (1) and control device (2), control device (2) is made of central control single chip computer, display device and the input equipment of power management module, the control module of infusion actuator, built-in control sequence, power supply is subjected to power management module control to each device power supply, and central control single chip computer has data wire to be electrically connected with control module, display device and the input equipment of power management module, infusion actuator respectively; It is characterized in that: described control device (2) also comprises the brain electricity monitoring module of being with electrode for encephalograms, and its output signal is connected to the signal input part of central control single chip computer by network interface.

2. propofol closed-loop target controlled infusions automaton according to claim 1 is characterized in that: described infusion actuator (1) is for being equipped with the controlled syringe pump of propofol; Or by controllable motor, turn-screw guide rail, be placed in the syringe that propofol is housed on the fixed mount and constitute, the output of controllable motor drives the turn-screw pushing syringe.

3. propofol closed-loop target controlled infusions automaton according to claim 1 and 2 is characterized in that: described infusion actuator (1) also comprises infusion ultimate position pick off, and it exports the central control single chip computer of control device to.

4. propofol closed-loop target controlled infusions automaton according to claim 3 is characterized in that: described display device is a LCDs, and described input equipment is keyboard or touch screen, and described power supply also comprises backup battery.

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