Technical background
Aloe is traditional medical material of motherland's medical science, and in the world, Aloe has just had report to the therapeutical effect of skin wound from twentieth century since the eighties.The research of Rodrignez-Bigas and Visuthikosold etc. shows that all the wound surface epithelization of employing Aloe treatment early.But China mostly is limited to cosmetic field in the application facet of Aloe external, accidental Aloe is applied to the trial of wound repair, but mostly be oiliness cream or dehydration ointment form greatly, be unfavorable for daily minor trauma treatment and nursing, the Aloe Pharmaceutical composition that adopts advanced substrate and convenient route of administration is needed in the present technique field badly, to treat various daily slight body surface wounds and ulcer effectively.
The present invention selects the substrate of polyacrylic resin (Carbopol) as described Pharmaceutical composition for use, carboxyl in this polymer makes it have a series of characteristics that are applicable to the preparation Wound dressing, Giroux and Sehrenzel etc. have studied Carbopol Gel Transdermal performance and human body tolerance, carried out the interior medicine dynamics test simultaneously, the result shows nontoxic, the nonirritant of this material, does not influence the physiologically active of medicine.The Carbopol gel application has series of advantages such as stable performance, permeability is strong, the human body compliance is good in the preparation of Wound dressing, and the carrying medicament molecule very easily discharges by the micelle passage in the Carbopol gel structure simultaneously.
Beneficial effect
The present invention has broken the technical monopoly of imported product in this field, overcome traditional product that present daily trauma care uses to a certain extent easily and the technological deficiency of wound adhesion, filled up domestic blank, the development of product of the present invention helps the raising of the whole research and development technology of national natural plants, and can provide novel effectively product and method for daily slight Wound treating.
Summary of the invention
An object of the present invention is to provide with Aloe, polyacrylic resin (Carbopol) and silver sulfadiazine is the hydrophilic gel form membrane Pharmaceutical composition of curing on non-weaving cloth (base material) of characteristic component.
A further object of the present invention provides the preparation method of described Pharmaceutical composition.
Another object of the present invention provides described Pharmaceutical composition in the medicinal application for the treatment of and nursing daily body surface wound, ulcer and various other traumatic wound surface.
The objective of the invention is to implement: a kind of Pharmaceutical composition by following method, its characteristic component is the Aloe mesophyll lyophilized powder of 10-60% (W/V), the silver sulfadiazine dry powder (antibacterial) of 0.05-2.0% (W/V), polyacrylic resin (Carbopol) dry powder of 0.1-5.0% (W/V) and the excipient of surplus.
Described Pharmaceutical composition is for solidifying in 12g/m2-260g/m2Hydrophilic gel form membrane on the non-weaving cloth (base material).PH value is 6.5-7.5.
Below in conjunction with specific embodiment the present invention is done further elaboration.
Embodiment 1:
Preparation contains 10% (W/V) Aloe mesophyll lyophilized powder, the described Pharmaceutical composition of 0.1% (W/V) silver sulfadiazine 0.1% (W/V) polyacrylic resin.
Take by weighing the commercially available polyacrylic resin of 1g (Carbopol), add among the sterile distilled water 900mL, at room temperature swelling is after 4 hours, and restir 4 hours makes abundant dissolving.Add commercially available 1: 1 Aloe mesophyll lyophilized powder of 100mL in this solution, the commercially available silver sulfadiazine dry powder of 1g is 6.8 with the triethanolamine adjust pH after the even matter, obtains the milky gelinite.Evenly coat 16g/m then2On the non-weaving cloth, obtain gel film behind the dry solidification.
Embodiment 2:
Preparation contains 20% (W/V) Aloe mesophyll lyophilized powder, the described Pharmaceutical composition of 10% (W/V) sulfanilamide and 0.5% (W/V) polyacrylic resin.
Take by weighing the commercially available polyacrylic resin of 5g (Carbopol), add among the sterile distilled water 695mL, at room temperature swelling is after 4 hours, and restir 4 hours makes abundant dissolving.Add commercially available 1: 1 Aloe mesophyll lyophilized powder of 200mL in this solution, the commercially available sulfanilamide dry powder of 100g is 6.8 with the triethanolamine adjust pH after the even matter, obtains the milky gelinite.Evenly coat 28g/m then2On the non-weaving cloth, obtain gel film behind the dry solidification.
Embodiment 3:
Preparation contains 30% (W/V) Aloe mesophyll lyophilized powder, 0.1% (W/V) nitrofural, the described Pharmaceutical composition of 3.0% (W/V) polyacrylic resin.
Take by weighing the commercially available polyacrylic resin of 30g (Carbopol), add among the sterile distilled water 670mL, at room temperature swelling is after 4 hours, and restir 4 hours makes abundant dissolving.Add commercially available 1: 1 Aloe mesophyll lyophilized powder of 300mL in this solution, 1g nitrofural dry powder is 6.8 with the triethanolamine adjust pH after the even matter, obtains the milky gelinite.Evenly coat 35g/m then2On the non-weaving cloth, obtain gel film behind the dry solidification.
Embodiment 4:
Preparation contains 40% (W/V) Aloe mesophyll lyophilized powder, and 1.0% (W/V) neomycin and 2.0% (W/V) polyacrylic resin are stated Pharmaceutical composition
Take by weighing the commercially available polyacrylic resin of 20g (Carbopol), add among the sterile distilled water 570mL, at room temperature swelling is after 4 hours, and restir 4 hours makes abundant dissolving.Add commercially available 1: 1 Aloe mesophyll lyophilized powder of 400mL in this solution, 10g polygynax dry powder is 6.8 with the triethanolamine adjust pH after the even matter, obtains the milky gelinite.Evenly coat 45g/m then2On the non-weaving cloth, obtain gel film behind the dry solidification.
Embodiment 5:
Preparation contains 60% (W/V) Aloe mesophyll lyophilized powder, 3.0% (W/V) gentamycin, the described Pharmaceutical composition of 0.1% (W/V) polyacrylic resin.
Take by weighing the commercially available polyacrylic resin of 1g (Carbopol), add among the sterile distilled water 370mL, at room temperature swelling is after 4 hours, and restir 4 hours makes abundant dissolving.Add commercially available 1: 1 Aloe mesophyll lyophilized powder of 600mL in this solution, 30mL 80,000 IU gentamicin sulfate solution are 6.8 with the triethanolamine adjust pH after the even matter, obtain the milky gelinite.Evenly coat 120g/m then2On the non-weaving cloth, obtain gel film behind the dry solidification.
Embodiment 6:
Preparation contains 20% (W/V) Aloe mesophyll lyophilized powder, 1.0% (W/V) silver sulfadiazine, 3.0% (W/V) clotrimazole (Clotrimazole), the described Pharmaceutical composition of 5.0% (W/V) polyacrylic resin.
Take by weighing the commercially available polyacrylic resin of 50g (Carbopol), add among the sterile distilled water 710mL, at room temperature swelling is after 4 hours, and restir 4 hours makes abundant dissolving.In this solution, add commercially available 1: 1 Aloe mesophyll lyophilized powder of 200mL, the commercially available silver sulfadiazine dry powder of 10g, 30g clotrimazole (Clotrimazole) dry powder is 6.8 with the triethanolamine adjust pH after the even matter, obtains the milky gelinite.Evenly coat 260g/m then2On the non-weaving cloth, obtain gel film behind the dry solidification.