A kind of adhesive bandage that contains hyaluronic acid biological compositionTechnical field:
The invention belongs to field of medicaments, relate to a kind of novel adhesive bandage that contains hyaluronic acid biological composition.
Background technology:
The adhesive bandage that uses mainly focus on the emergency protection to wound, but itself can not really play therapeutical effect to wound at present, even soaked the adhesive bandage of anti-inflammation drugs, still faces the difficult problem of repair in trauma, cicatrization.Repair in trauma is a complex physical process, it is one of sixty-four dollar question of medical circle concern always, research with adhesive bandage product of Wound healing and bone regeneration and repair in trauma also is the important medical problem always, and another important difficult problem is the formation that how to alleviate or eliminate the spot of following behind the wound healing.Traditional wound dressing is often paid attention to around how protecting wound and design, and the healing of wound mainly relies on self healing of human body, its result prolongation of wound healing time and formation of cicatrix often.Along with Biomedical Development, basic variation has also taken place in the dressing and the material that are used for wound, not only can have protection, isolated effect to wound, and has the effect of antiinflammatory, promotion wound healing.Simultaneously, along with people's deepening continuously to the research of wound healing mechanism, pay close attention to the formation of cicatrix in the wound healing process more and more, the patent that is used to not have cicatrix wound healing preparation and do not have the cicatrix adhesive bandage is disclosed, U.S. Pat P5604200 has introduced and has a kind ofly contained hyaluronic acid and the blood plasma fibronectin is the combination of features thing, is used to promote the wound healing in uterus; U.S. Pat P6355858 then relates to a kind of wound coated material, containing non-gel-type polysaccharide such as galactomannan (galactomanan), somatomedin becomes to grade as fibroblast growth factor (bFGF), the nerve growth factor (NGF), epidermal growth factor (EGF), CRH ELISA releasing factor bioactive ingredients such as (CRF) and anti-inflammation, this material can promote wound healing, reduces the formation of cicatrix; U.S. Pat P6262020 discloses and has a kind ofly contained hyaluronic acid and serpin is the Wound healing and bone regeneration compositions of feature; Chinese patent CN1128762.4 relates to a kind of hyaluronic scarless Biocomposite material that contains, and its composition has been simulated the composition of amniotic fluid, has the wound healing of promotion, reduces synulotic effect; Chinese patent CN 02111594.X discloses then that a kind of to contain compositions such as chitosan, type i collagen, medicament be the biological compound adhesive bandage of feature, is used for wound healing, has good penetration, elasticity and pliability.
In having the Patent data that promotes wound healing, elimination cicatrix effect, bioactie agent mainly contains the solution system of hyaluronic acid, chitosan, blood plasma fibronectin, serpin or the design of simulated amniotic fluid composition, and hyaluronic acid then is used as the key factor that promotes the scar-free wound healing.
Hyaluronic acid (English name: Hyaluronan HA) be a kind of linear polysaccharide of uniqueness, it is the important component in the extracellular matrix aminoglycan, discover, it is directly related to be rich in hyaluronic acid in the no scar healing of fetus wound and its growing environment amniotic fluid, in wound healing, oneself is proved hyaluronic acid and has following effect: 1. the grumeleuse of forming with fibrin is brought into play conformation function in wound healing process, 2. by promoting granulocytic activate the phagocytic capacity to regulate inflammatory reaction, 3. the low-molecular-weight hyaluronic acid of localized degradation generation promotes angiogenesis, 4. regulates and control the synthetic of collagen.The Histological research that is directly used in wound face has proved that also the external source hyaluronic acid can activate the granulation tissue generation and papilla cell occurs.In addition, the water conservation of HA excellence, lubricating ability and tissue adhesion's effect thereof also provide foundation for its effect in extensive wound treatment treatment.
Trehalose (English name: be to be prevalent in antibacterial trehalose); yeast; algae; plant; the intravital a kind of non-reducing disaccharide of insecticide and other invertebratess; trehalose has non-specific protective effect to biological tissue and biomacromolecule; biomembrane in can stabilized cell; the structure of biomacromolecule such as protein and nucleic acid; keep cytoactive; effect with other compositions incomparable " water substitutes "; because the physiologically active of this uniqueness; the Application and Development of trehalose receives increasing concern in recent years; keep the factor as ideal biological activity, trehalose is applied to field of medicaments more and more.
Allantoin (English name: Allantoin) be a kind of imidazoles composition, has the stimulation tissue growth, promote cell metabolism, accelerating wound, physiological functions such as soften cuticle protein, be the good consolidant of skin trauma, allantoin is widely used in the skin trauma medicine, and is especially remarkable for suppurative skin wound treatment effect.
Summary of the invention:
The object of the invention is to disclose a kind of hyaluronic biological composition that contains, and this compositions also contains characteristic chemical constituent trehalose and allantoin except that containing hyaluronic acid, may contain the anti-inflammation hemostasia composition simultaneously.
The present invention is an important physiological function of utilizing hyaluronic acid, trehalose, these three kinds of ingredients of allantoin, it is creatively combined, this compositions is used for skin trauma, postoperative wound healing, can prevent wound inflammation, keep the wound circumference moist environment, stimulate wound tissue's cell growth, shorten wound healing time, alleviate the skin pruritus of wound, simultaneously can alleviate and eliminate the formation of cicatrix, make skin smooth after the healing, attractive in appearance.
The invention reside in provides a kind of biological composition that contains hyaluronic acid, trehalose and allantoin, in compositions, the ratio of hyaluronic acid, trehalose, allantoin, its quality proportioning is 1: (5～100): (2～100), promptly 1 part of hyaluronic acid is equipped with 5～100 parts trehalose and 2～100 parts allantoin, press the total mass ratio of mixture simultaneously, contain 0～5% anti-inflammation hemostasia composition.
The component ratio content of optimizing, hyaluronic acid: trehalose: allantoin is 1: (10～50): (5～50), and press the total mass ratio of mixture simultaneously, contain 0～2% anti-inflammation hemostasia composition.
The hyaluronic acid of indication of the present invention can be hyaluronic salt, contains but is not limited to sodium salt, potassium salt.Indication trehalose of the present invention can be no water of crystallization trehalose, it also can be the trehalose that contains water of crystallization, if directly use the dry powder of compounding ingredients, then adopt no water of crystallization trehalose, if use after component made solution, then both can use no water of crystallization trehalose, and also can use to contain the water of crystallization trehalose.Used hyaluronic acid and trehalose should meet medical rank.
The used allantoin of the present invention meets the medicinal rank of Chinese Pharmacopoeia.
The anti-inflammation hemostasia composition of indication of the present invention can be any material that is generally used for anti-inflammation hemostasia in this area, as antibiotic, bromo geramine, chlorhexidine acetate, metronidazole, PVC iodine etc.
Preparation technology of the present invention is according to proportioning weighing, mixing with mentioned component, can directly mixture evenly be coated on the interior surface layers wound protective bandage pad and non-woven fabrics of adhesive bandage as sealing coat, the drug dose of unit are is decided by the adsorbance of medicine, according to the production technology processing of general adhesive bandage.
Preparation technology of the present invention is according to the technological requirement dissolved in purified water with mentioned component, make certain density solution, to make wound protective bandage pad that adhesive bandage uses and be soaked in the solution as the non-woven fabrics of sealing coat internal layer, or solution evenly is sprayed on the internal layer non-woven fabrics, to contain the oven dry of the wound protective bandage pad of medicinal liquid and non-woven fabrics, sterilization, form according to the production technology processing of general adhesive bandage.
Characteristics of the present invention are on the basis of existing adhesive bandage, adopt coating, medicinal liquid to soak, spray a kind of hyaluronic compound bio component that contains at adhesive bandage wound protective bandage pad and/or internal layer isolation surface, it is feature that this compound bio component contains hyaluronic acid, trehalose and allantoin, may contain antiinflammatory, sterilization, hemostatic compositions etc. simultaneously.
Adhesive bandage of the present invention, be that hyaluronic acid is mixed with an amount of trehalose, allantoin, form a compounding ingredients, adopt the method for coating, solution soaking or sprinkling that ingredient is attached on wound protective bandage pad and the internal layer non-woven fabrics as sealing coat this compounding ingredients.This adhesive bandage is owing to contain hyaluronic acid, trehalose and allantoin; the liquid that oozes out owing to wound during use is with these ingredients dissolvings; just form a kind of viscosity membrane layer in wound surface; membrane layer can effectively be protected wound; alleviate the stimulation of outer bound pair wound, promote epithelial growth, keep the proteic activity of fiber adhesion; promote wound healing, reduce the formation of cicatrix.Adhesive bandage of the present invention is used for hemostasis, the healing of large tracts of land wound or operation process wound, also has the effect that prevents the tissue adhesion.
Adhesive bandage of the present invention can be used for general skin injury wound, also can be used for large-area general wound, also can be used for wound hemostasis, promotion wound healing, minimizing cicatrization after surgical wound is sewed up.
Embodiment:
Below be embodiments of the invention, these embodiment only are used for illustrative purposes, do not constitute limitation of the scope of the invention.
Embodiment 1:
Take by weighing aseptic hyaluronate sodium powder 1g in the gnotobasis, trehalose 10g, allantoin 10g, mupirocin (mupirocin) 0.4g, mix homogeneously, blended medicated powder evenly is sprayed on aseptic nonwoven gauze, the nonwoven gauze as adhesive bandage directly contact wound internal layer, the production technology processing of pressing adhesive bandage gets final product.
Embodiment 2:
In the gnotobasis, take by weighing aseptic hyaluronate sodium powder 1g, trehalose 50g, allantoin 30g, chlorhexidine acetate 0.2g is with above-mentioned medicated powder mix homogeneously, be sprayed on the aseptic non-woven fabrics, non-woven fabrics is as the internal layer of adhesive bandage, and the production technology processing of pressing adhesive bandage gets final product.
Embodiment 3:
Take by weighing aseptic hyaluronate sodium 10g, trehalose 200g, allantoin 150g, bromo geramine 1g is dissolved in mentioned component in the 2000ml medicinal sterile pure water, 400g nonwoven gauze is put into this solution soak.Take out non-woven fabrics, drying passage infrared ray radiation after drying, other are made with general adhesive bandages, exterior and interior packing after oxirane disinfection get final product.