CN1669522A

Movatterモバイル変換

Info

Publication number: CN1669522A
Application number: CN 200510067188
Authority: CN
Inventors: 许建平
Original assignee: Individual
Current assignee: Individual
Priority date: 2005-04-19
Filing date: 2005-04-19
Publication date: 2005-09-21

Abstract

The invention relates to a kind of measuring apparatus and methods, which is contacting with the arterial vessel surface nearby the life body by transducer, and measuring the followings through life body vessel: blood pressure, pulse frequency, cardiac frequency, blood flow volume, blood drag force and vascular sclerosis parameter. It can also be applied in hand-held communication apparatus, or personal digital assistant, comprising: measuring probe to measure the life body vascular system physical characteristic parameter; ways to judge whether the transducer can detect the diastolization pressure; ways to calculate and ascertain diastolization pressure by the detected waveshape if the transducer hasn't detected it; and pressure or displacement transducer. The invention makes the blood pressure measuring device more simple, smaller and more convenient to use.

Description

Vascular measurement device and method

Technical Field

The invention relates to a method for measuring by a living body blood vessel, by contacting a sensor with the skin surface of the living body adjacent to an artery blood vessel: devices and methods for measuring blood pressure, pulse rate, heart rate, blood flow, blood resistance, vascular stiffness parameters, etc., and uses of the devices and methods in handheld communication devices, or personal digital assistants, and pressure or displacement sensors, but are not limited thereto.

Background

At present, many known methods and devices for measuring blood pressure and pulse characteristics of a living body by using pressure and displacement sensors are available, such as: chinese patent application publication, application number: 01820020.6, name: the patent application "method and apparatus for monitoring blood pressure" discloses a device for monitoring the arterial blood pressure of a user by continuously sensing said blood pressure and generating a signal representative thereof by contact with the external surface of the body of the user at a location adjacent to the artery by means of a sensor device; the method has the following defects: during measurement, the sensor moves along with the expansion and contraction of the artery blood vessel, so that the measurement sensitivity, reliability and accuracy are poor; when measuring, the instrument is fixed by a belt, and the ulnar artery or the radial artery of the wrist cannot be measured independently; large measurement errors can be caused due to the expansion and contraction of muscles of a human body; to obtain the necessary precision, an external calibration and correction device is required to be used continuously, so the use is inconvenient, and the production and use costs are high; chinese patent application publication, application number: 03152232.7, name: the patent application of 'method and equipment for determining blood pressure by using pressure pulsation duty ratio' discloses a method for obtaining blood pressure artery data in an oscillometric mode, and has the defects that a pressurized air device is needed, so that the use is inconvenient, and the production and use costs are high.

Disclosure of Invention

The invention aims to: the above-mentioned shortcomings of the prior art are overcome, and a measuring device and method for blood pressure, pulse rate, heart rate, blood flow, blood resistance, blood vessel sclerosis parameters, blood vessel elasticity parameters, blood pressure variation waveform and the like of a living body, which is simple and rapid in user correction, low in cost, high in accuracy and reliability, are provided.

The purpose of the invention is realized by the following ways:

the basic principle of the invention is as follows: the physical characteristic parameters of the blood vessel are measured by balancing the pressure between the elastic telescopic measuring contact of the sensor and the blood vessel (including the skin of a living body) by means of the elastic telescopic performance of the measuring head of the sensor.

According to one aspect of the invention:

a measuring probe for measuring a physical characteristic parameter of a vascular system of a living body by contacting a sensor with a skin surface of an adjacent artery vessel of the living body, comprising: the pressure sensor or the displacement sensor is provided with a support with a supporting leg, and a measuring contact can elastically stretch; the measuring contact can be an elastic telescopic pressure sensor or a displacement sensor which is arranged on the bracket.

According to a second aspect of the invention:

a method for judging whether a sensor measures diastolic pressure by contacting the sensor with the skin surface of an adjacent artery blood vessel of a living body is to determine whether the sensor measures the diastolic pressure by judging whether the duration of the lowest value of blood pressure data measured by the sensor is within a predetermined time range. Wherein, at least one of the following is included:

(1) and if the duration of the lowest value of the blood pressure data measured by the sensor is within the preset time range, the lowest value of the blood pressure data measured by the sensor is the diastolic blood pressure value.

(2) And if the duration of the lowest value of the blood pressure data measured by the sensor is not within the preset time range, the lowest value of the blood pressure data measured by the sensor is not the diastolic pressure value.

(3) If the duration of the lowest value of the blood pressure data measured by the sensor is not within the predetermined time range, that is, when the diastolic pressure is not measured, the method for determining the diastolic pressure is as follows: the method comprises the following steps:

recording the blood pressure waveform of at least one cardiac cycle measured by the sensor,

the duration of the lowest value of the blood pressure data measured by the sensor is determined,

on the convex part in the blood pressure waveform measured by the sensor, finding a constant amplitude time line of which the amplitude is the same and the duration is the same as the duration of the lowest value of the blood pressure data measured by the sensor according to the duration of the lowest value of the blood pressure data measured by the sensor, wherein the starting point and the ending point are on the convex part in the blood pressure waveform measured by the sensor, and determining a vertical line data value from the constant amplitude time line to the peak point of the blood pressure waveform, thereby,

the value of the difference between the lowest value of the blood pressure waveform measured by the sensor and the data value of the vertical line connecting the constant amplitude time to the peak point of the blood pressure waveform on the convex part of the blood pressure waveform is the diastolic pressure value. Or,

on the convex part in the blood pressure waveform measured by the sensor, finding out a constant amplitude time connecting line of which the amplitude is the same and the duration is the same as the duration of the lowest value of the blood pressure data measured by the sensor according to the duration of the lowest value of the blood pressure data measured by the sensor, and the starting point and the ending point are on the convex part in the blood pressure waveform measured by the sensor, and determining a vertical line data value from the constant amplitude time connecting line to the peak point of the blood pressure waveform,

the data value of the vertical line connecting the constant amplitude time to the peak point of the blood pressure waveform is corrected by a correction coefficient, the data value of the difference between the lowest value of the blood pressure waveform measured by the sensor and the convex portion of the blood pressure waveform, the data value of the vertical line connecting the constant amplitude time to the peak point of the blood pressure waveform corrected by the correction coefficient is the diastolic blood pressure value, or,

the value of the difference between the lowest value of the blood pressure waveform measured by the sensor and the data value of the vertical line connecting the constant amplitude time to the peak point of the blood pressure waveform on the convex part in the blood pressure waveform is the diastolic pressure value after being corrected by the correction factor.

The method according to the present invention can be made into a machine-readable computer code by means of coding, or an operational computer code, or a control program stored in a storage medium and actually applied to the measuring device; for example: a handheld communication device, or personal digital assistant, or the like.

According to a third aspect of the invention:

a measuring apparatus for measuring a blood pressure of a living body by bringing a sensor into contact with a skin surface of an artery adjacent to the living body, comprising a pressure sensor portion, or a displacement sensor portion, an electric signal processing portion, a display portion, a belt, etc., wherein: the device comprises a support, a pressure sensor, a displacement sensor, a pressure sensor and a displacement sensor, wherein the support is provided with at least two support legs, the pressure sensor is provided with a measuring contact which can elastically stretch out and draw back, the displacement sensor is arranged on the support, and the pressure sensor is provided with a measuring contact which can elastically stretch out and draw back, or the displacement sensor is provided with a measuring contact which faces the support; the bridle is a flexible bridle or a rigid retainer, and when the bridle is used for fixing and measuring the pressure of the blood vessel by arms, wrists and fingers, the length direction of the bridle is crossed with a connecting line between supporting legs of the bracket.

A measuring device for measuring blood pressure of a living body by bringing a sensor into contact with a skin surface of an artery adjacent to the living body, comprising a pressure sensor portion, or a displacement sensor portion, an electric signal processing portion, a display portion, and the like, wherein at least one of:

(1) and a display section including: and reminding a user of judging whether the measurement result is valid or not when the measurement is carried out, or informing the user of the contact force value of the blood vessel measurement sensor measurement contact head and the living body, or at least one of visual information such as letters, symbols, figures, numbers and the like, wherein the contact force is in a specified value range or not. Or,

(2) the measuring device includes: and the sound device is used for reminding the user whether the measurement result is valid or not when the user judges the measurement, or informing the user that the blood vessel measurement sensor measures the contact force value between the contact and the living body or whether the contact force is within a specified value range or not.

The above-described technique of the present invention may be completely implemented in one blood pressure measurement device, or may be partially implemented in different measurement devices. For example: the measuring probe for measuring the physical characteristic parameters of the vascular system of the living body can be used for a measuring device of blood pressure; a measuring device for vascular sclerosis parameters; a measuring device for the elastic parameters of the blood vessel; can be used for pulse rate device and heart rate measuring device; a measuring device useful for blood flow; a measuring device that can be used for blood resistance; a device for measuring the waveform (change) of blood pressure; and so on.

Compared with the prior art, the invention has the following advantages:

as a blood pressure measuring device, the device is convenient and simple to use, has higher measuring precision, stability and reliability, and has lower production and use costs.

The basic principle of the invention is as follows: the pressure balance between the elastic telescopic measuring head of the sensor and the blood vessel (between the measuring head of the sensor) is used for measuring by depending on the elastic telescopic performance of the measuring head of the sensor; in the case of an unclosed artery, the invention still allows the measurement of blood pressure; the invention is therefore of considerable advantage when monitoring the continuous blood pressure of patients suffering from (cardiovascular etc.) a high degree of illness. For example: the basic principle of the chinese patent application No. 01820020.6 is: adapting "a convex portion of the sensor device to effect at least partial occlusion of the artery at the site"; this is a considerable disadvantage in the continuous monitoring of blood pressure in patients with (cardiovascular, etc.) high disease, and in addition, the pressing of the sensor boss into the user's body can be uncomfortable for the user.

Drawings

FIG. 1 is a schematic longitudinal sectional view of a measuring probe for measuring physical characteristic parameters of a vascular system of a living body according to the present invention;

FIG. 2 is a bottom view of the measurement probe of FIG. 1;

FIG. 3 is an external view of a measurement probe for measuring physical characteristic parameters of the vascular system of a living body in the form of a sensor support foot according to the present invention;

FIG. 4 is a bottom view of the measurement probe of FIG. 3;

FIG. 5 is a schematic cross-sectional view of a measurement probe measuring a radial artery blood vessel of a wrist of a human body;

FIG. 6 is a schematic front view of FIG. 5;

FIG. 7 is a partially enlarged schematic view of the measurement section shown in FIG. 6;

FIG. 8 is a schematic cross-sectional view of the measurement probe of FIGS. 3 and 4 for measuring the radial artery blood vessels of the wrist of a human body;

FIG. 9 is an external view of a wrist-watch type blood pressure measuring device according to the present invention;

FIG. 10 is a side schematic view of FIG. 9;

FIG. 11 is a bottom schematic view of FIG. 9;

FIG. 12 is a schematic diagram of the exterior of a mobile phone for measuring blood pressure and pulse rate according to the present invention;

FIG. 13 is a schematic view of the back of a mobile phone with a sensor support foot for measuring blood pressure and pulse rate according to the present invention;

FIG. 14 is a schematic diagram showing a blood pressure waveform when a blood vessel sensor measures diastolic and systolic pressures when a blood vessel measuring probe according to the present invention measures blood pressure of a living body;

FIG. 15 is a schematic view showing a blood pressure waveform when a blood vessel sensor does not measure a diastolic blood pressure when a measurement probe according to the present invention measures a blood pressure of a living body;

FIG. 16 is a schematic diagram showing a blood pressure waveform when a blood vessel sensor measures diastolic pressure when a measurement probe of the present invention measures blood pressure of a living body;

FIG. 17 is a schematic diagram showing a blood pressure waveform when a blood vessel sensor does not measure a diastolic pressure when a measurement probe of the present invention measures a blood pressure of a living body;

FIG. 18 is a schematic diagram of the measuring probe of the present invention for determining the diastolic blood pressure value when the blood vessel sensor does not measure the diastolic blood pressure;

FIG. 19 is a schematic diagram of a circuit for blood pressure, pulse rate monitoring;

FIG. 20 is a schematic diagram of a microprocessor based blood pressure and pulse rate monitoring circuit;

FIG. 21 is a schematic diagram of a microprocessor based blood pressure, pulse rate monitoring circuit;

FIG. 22 is a schematic block diagram of a communications environment of the present invention.

Detailed Description

The invention is further illustrated with reference to the following figures and examples.

As shown in fig. 1 and fig. 2, a measuring probe for measuring physical characteristic parameters of a vascular system of a living body according to the present invention is illustrated, which is composed of a silicon film 103 formed on a substrate 101, a gas 104, a cylindrical housing 102, a circular plate type elastic sealing housing 105 (made of a material such as gel), a contact 107, a circular plate type piston 106, and the like; the gas is sealed inside the housings 101, 102, 105, thus constituting a pressure sensor, or displacement sensor, of the invention, in which the measuring feeler can elastically expand and contract, also referred to as: "vascular pressure measurement sensor"; such as: when the contact 107 is pressed, the elastic sealing shell 105 drives the piston 106 to move inwards, the gas 104 is compressed, the density is increased, and when constant current is introduced to the input end of the silicon film 103, the current of the output end changes; for a piezoresistor (silicon film sensor chip, such as 103) with the linear change relationship between the pressure and the resistance, a compression part can be designed into a piston type according to the Boyle-Mariotte law, so that the motion displacement of a measuring contact, the compression volume of gas and the pressure of the gas are in the linear change relationship; meanwhile, "Charles' law" should be considered to correct the influence due to the temperature change. Where 110 is the electrical outlet (pin) of the sensor. 111 is a board for mounting sensors and other electronic components, 112 is a housing, and support

legs

108, 109 are mounted on thehousing 112, so that 112, 108, 109 form a frame with the

support legs

108, 109, wherein theelastic measuring contact 107 is outside the

support legs

108, 109, or is higher than the leg end faces of the

support legs

108, 109, as shown in fig. 1 at H; pressure and displacement sensors (110, 101, 103, 102, 105, 106, 107) which can be extended and contracted are arranged on

brackets

112, 108, 109 with supporting

feet

108, 109 to form the measuring probe for measuring the physical characteristic parameters of the vascular system of the living body. It should be noted that the

support feet

108, 109 may also be made as height adjustable support feet, which is advantageous for users with different skin, vessel thickness, spring rate, etc.

Therefore, in the invention, the support is a support with a side supporting leg capable of acting on the artery and the blood vessel of the living body; the supporting legs of support include: supporting legs with fixed height; the height of the supporting legs can be adjusted in a telescopic way; the height can be adjusted by elastic expansion and contraction (such as gel supporting leg with gas in the core made of gel), the sensor supporting leg can be adjusted by elastic expansion and contraction; the pressure self-adaptive supporting leg is provided; the supporting legs can automatically adjust the height according to the pressure acting on the bracket; supporting legs with the height automatically adjusted according to the ambient temperature; the supporting legs automatically adjust the height according to the environmental temperature and the pressure acting on the bracket; and so on.

For the pressure sensor or displacement sensor with elastically stretchable measuring contacts, refer to the specification of chinese patent application No. 20041005471.3, wherein such sensor is discussed in detail, however, the description of the pressure or displacement sensor should refer to a piston inside an elastic shell, so that the piston is linearly changed along with the movement of the elastic shell, that is: the change of the mass point displacement (hard object)/the volume in the piston cavity/the gas pressure on the elastic shell is in a linear relation, and meanwhile, the influence of the change of the environmental temperature can be considered. It should be understood, of course, that for the chinese patent, specification No. 20041005471.3, the tilt sensor, angular velocity sensor, angular acceleration sensor, velocity, acceleration sensor, vibration sensor, and electronic switch thereof, the interior of the elastic housing of the sensor should be a piston that is driven to move linearly with the movement of the elastic housing, i.e.: the change of the mass point displacement (hard object)/the volume in the piston cavity/the gas pressure on the elastic shell is in a linear relation, and meanwhile, the influence of the change of the environmental temperature can be considered.

Fig. 3 and 4 show the variations of fig. 1 and 2 of the present invention, namely: the support legs (108, 109) in fig. 1 and 2 are transformed into elastically extensible pressure sensors or displacement sensor support legs, i.e. sensor support legs in which the measuring contacts are extensible.

In fig. 3 and 4, another measuring probe for measuring physical characteristic parameters of the vascular system of a living body is shown, and the probe is composed of three pressure sensors or displacement sensors, wherein the pressure sensors or the displacement sensors can extend and retract. Thesubstrate 204, thesilicon film 207, the gas 213 (gas sealed by 204, 210, 216), thecylindrical housing 210, the circular plate type elastic sealing housing 216 (made of gel or other materials), thecontact 221, the circularplate type piston 220, the electrical lead (pin) 222, and the like form a blood vessel pressure measuring sensor with a measuring contact capable of elastic expansion and contraction. Thesubstrate 203, the silicon film 206, the gas 212 (gas sealed by the

substrates

203, 209, 215, and 218), thecylindrical housing 209, the bellows-shaped elastic sealed housing 215 (made of a material such as gel), the plunger-type contact 218, the electric lead (leg), and the like constitute one "elastically stretchable sensor support leg". Similarly, thesubstrate 205, thesilicon film 207, the gas 213 (gas sealed by 205, 211, 217, 219), thecylindrical housing 211, the bellows-shaped elastic sealing housing 217 (made of a material such as gel), theplunger contact 219, the electrical lead (pin), etc. form another "elastically stretchable sensor support leg", 202 is a circuit board for mounting the sensor, and 201 is a housing. The 'elastically stretchable sensor supporting legs' firstly and secondly can remind a user of whether the contact force of a measuring contact of a blood vessel measuring sensor on the surface of the skin of a blood vessel is proper or not according to the measured pressure average value; that is, for an individual user, when the arterial blood vessel measuring probe of the present invention is used at a fixed site, in order to meet the accuracy of measurement, first, measurement is performed using a standard blood pressure measuring device, then, measurement is performed using the arterial blood vessel measuring probe of the present invention, by applying different pressures to the arterial blood vessel measuring probe of the present invention, when the arterial blood pressure measured by the arterial blood vessel measuring probe of the present invention is the same as the blood pressure measured by the standard blood pressure measuring device, the average value of the pressures measured by the "elastically stretchable sensor support legs" (i) and (ii) is recorded, so that the individual user is informed when arterial blood vessel pressure measurement is performed at the same site in the future, whether the pressure applied to the arterial blood vessel measuring probe is proper or not is determined, and the user can conveniently adjust the pressure applied to the measuring probe. Of course, the average value of the pressure measured by the 'elastically stretchable sensor supporting legs' is recorded, and the average value can be used for adjusting and correcting the output electric signal of the arterial blood vessel measuring sensor so as to meet the measuring accuracy.

The measuring probe for measuring the physical characteristic parameters of the vascular system of the living body shown in fig. 1, fig. 2, fig. 3 and fig. 4 is applied to measuring the physical characteristic parameters of the vascular system of the living body, such as: the measurement of blood pressure, pulse rate, blood flow, blood resistance, vascular sclerosis, etc. is carried out by fixing a stent on the skin surface of an artery vessel of a living body, beside the artery vessel, pressing a sensor measuring contact for measuring the blood vessel pressure on the skin surface of the artery vessel of the living body, and contacting the sensor measuring contact with the skin surface of the body of the artery vessel of the living body. When the blood pressure in the artery and the blood vessel of the living body changes, the contact of the sensor changes along with the expansion and contraction of the blood vessel; when constant current is introduced to the input end of the sensor, the current of the output end changes along with the expansion and contraction of the blood vessel; namely, the present invention provides: the measuring contact can be an elastic telescopic pressure sensor, or the output electric signal of the displacement sensor changes.

For example: the systolic pressure of the blood pressure of the living body can be detected by checking the peak value of the electric signal output by the sensor; the diastolic pressure of the blood pressure of the living body can be detected by detecting the valley value of the electric signal output by the sensor; detecting a parameter indicative of a pulse rate, or heart rate, of the living subject by detecting a time of a blood pressure valley electrical signal, or recording a blood pressure waveform peak value per second, or a number of valley points; the concept of arteriosclerosis is judged by detecting pulse waves (pulse conditions), see application No.: 93226716.5, but includes: amount of arterial vessel sclerosis, elasticity parameters, etc.; the blood pressure values of more than two parts of a living body are measured, and fluid mechanics formulas are applied to calculate and compare (peak value or valley value), so that the blood flow volume, blood resistance and the like of the living body can be detected.

FIG. 5, FIG. 6 and FIG. 7 are schematic views showing the measuring probe of FIGS. 1 and FIG. 2 contacting the skin surface of the radial artery blood vessel of the wrist of a living body, and the measuring principle is schematic; 301 is the cross section of the wrist of the human body, 302 is the blood vessel of the radial artery of the wrist, 303 is the measuring probe shown in figure 1; wherein the supporting feet (shown as 108 and 109 in figure 1) are arranged on two sides of the blood vessel of the radial artery of the wrist; meanwhile, it should be understood that the support leg of the bracket of the invention has the function of controlling the contact force between the contact and the living body, namely, controlling the sensitivity and the measuring range of the sensor, and at the same time, can stabilize the contact between the contact of the sensor and the surface of the blood vessel skin of the living body and stabilize the basic point of the sensor.

With the above, the pressure sensor or displacement sensor of the present invention, which can elastically stretch and contract, should be manufactured by selecting the elastic stretching and contracting performance of the measuring contact, such as: the structural shape, material property, thickness, etc. of theelastic sealing housing 105 in fig. 1, and the height of the supporting

legs

108, 109, or the height of thecontact 107 from the end faces of the supportinglegs 108, 109 (indicated by H in fig. 1) should be selected during manufacturing, and of course, the elastic expansion and contraction properties (expansion amount, elasticity) of the blood vessel measurement sensor, etc. should also be selected to satisfy the requirement that when the blood pressure of a living body changes during measurement of the present invention, themeasurement contact 107 expands and contracts along with the expansion and contraction of the blood vessel, and the output electrical signal of the sensor changes.

FIG. 8 is a schematic cross-sectional view of the measurement probe of FIG. 3, FIG. 4, taken along a radial artery of a wrist of a human being for measurement of a blood vessel of the wrist; wherein 401 is a section of a human wrist, 402 is a blood vessel of a radial artery of the wrist, and 403 is a measuring probe shown in FIG. 3; in fig. 3, the elastic expansion and contraction performance (expansion amount, elasticity) of the "elastically expandable and contractible sensor support leg" and the like should be selected during manufacturing, and of course, the elastic expansion and contraction performance (expansion amount, elasticity) of the blood vessel measurement sensor and the like should also be selected in the same way, so that when the blood pressure of a living body changes during measurement according to the present invention, the measurement contact expands and contracts along with the expansion and contraction of the blood vessel, and the output electrical signal of the sensor changes.

It should also be understood that other sensors, other than the present invention, in which the measuring contacts are elastically stretchable, may also implement the present invention. For example, a resistive contact sliding type displacement sensor having a spring device, chinese patent application No.: 88107691.0, and the like.

It should be noted that: the measuring probe for measuring the physical characteristic parameters of the blood vessel system of the living body can also be arranged on a personal digital assistant (device), and can be used for reasonably nursing the health of the person by regularly detecting and recording the health condition data of the blood pressure, the pulse rate, the blood vessel hardness and the like of the person.

FIG. 12 illustrates an external side view of a handset capable of measuring blood pressure and pulse rate; wherein 601 is a folding mobile phone (flip mobile phone), 602 and 604 are supports installed on the back of the mobile phone, and 603 is a measuring contact of a sensor; FIG. 13 is a schematic diagram of the external back of another mobile phone capable of measuring blood pressure and pulse rate; wherein 701 is a folding mobile phone (flip mobile phone), 702 and 704 are 'elastically stretchable sensor supporting legs' mounted on the back of the mobile phone, and 703 is a blood vessel measuring sensor; it should be understood that the corresponding measurement circuitry, or processor, software, etc., should be configured within the handset. Therefore, the measuring probe for measuring the physical characteristic parameters of the vascular system of the living body can also carry out measurement by pressing and stabilizing the fingers of the user. Of course, other types of mobile phones, GPS satellite navigation devices, GPRS devices, and personal digital assistants (devices) may be installed in the appropriate locations; with particular reference to fig. 1-4 and so on.

After batch manufacturing, the pressure and the pulse (bracket) of the measuring probe for measuring the physical characteristic parameters of the vascular system of the living body are different from the basic pressure applied by the measuring contact of the vascular measuring sensor on the skin for users with different skin elasticity or users with different using methods; if the basic pressure applied by the blood vessel measuring sensor measuring contact on the blood vessel skin is appropriate after the pressing and the bundling, the sensor measuring head can measure the valley point of the blood pressure waveform, as shown in fig. 14 and 16, which show the schematic diagram of the blood pressure waveform when the blood vessel measuring sensor measures the diastolic pressure when the measuring probe of the present invention measures the blood pressure of the living body. If the basic pressure applied to the blood vessel skin by the blood vessel measuring sensor measuring contact is not appropriate after pressing and bunching, the blood vessel measuring sensor measuring head can not completely measure the blood pressure waveform valley point, as shown in fig. 15 and 17, which show the schematic diagram of the blood pressure waveform when the blood vessel measuring sensor does not measure the diastolic pressure when the measuring probe of the invention measures the blood pressure of a living body; it should be noted that: during the design and manufacture, the measurement range of the contact is measured, and the elastic property of the contact can meet the blood pressure waveform change range of a living body, namely, the peak value and the valley value of a required waveform can be measured; for example: for human arterial blood pressure: the measurement range satisfies 0-300 mmHg.

In order to remind a user whether a measurement result is effective or not when the measurement is judged, or inform the user whether the contact force value of the sensor measuring probe and a living body is within a specified value range or not, or whether a blood pressure valley point can be measured by a blood vessel measuring sensor measuring contact; the invention relates to a measuring device for measuring blood pressure of a living body by contacting a blood vessel measuring sensor with the skin surface of an artery adjacent to the living body, in particular to a blood pressure measuring device which expresses diastolic pressure by the valley value of an electric signal output by the sensor, and the measuring device is designed and manufactured, and is provided with: reminding a user to judge whether a measurement result is valid or not when the measurement is carried out, or informing the user that the blood vessel measuring sensor measures the contact force value of the contact and the living body, or whether the contact force is in at least one of visual information such as letters, symbols, figures, numbers and the like within a specified value range; alternatively, the measuring device is provided with: and the sound device is used for reminding the user whether the measurement result is valid or not when the user judges the measurement, or informing the user that the blood vessel measurement sensor measures the contact force value between the contact and the living body or whether the contact force is within a specified value range or not.

Fig. 9, fig. 10 and fig. 11 are schematic diagrams of a wrist-watch type blood pressure measuring device according to the present invention; the display surface of the device is provided with numbers 80-120 (variable liquid crystal display) for displaying diastolic pressure and systolic pressure, and the display surface is also provided with at least one type of visual information OK (including NO) such as letters, symbols, figures, numbers and the like; for example: if the measurement is valid, OK is lighted, and NO is not lighted; if the measurement is invalid, NO is lightened, and OK is not lightened; of course, all other visual information such as other symbols, letters, names, graphics, numbers (including numbers representing the contact force values) and the like may be used to inform the user whether the measurement is valid, or whether the blood vessel measurement sensor measures the contact force value of the stylus against the living body, or whether the contact force is within a specified range of values; of course, the user may be informed whether the measurement result is valid, or whether the blood vessel measuring sensor measures the contact force value between the contact and the living body, or whether the contact force is within a specified value range. In fig. 8, 80-12 represent measured diastolic-systolic values, and 12:00 represents time with a reference to a change in blood pressure at different times. Wherein 501 is a watchband (flexible belt), 503 is a display surface, 502 is a shell, and 504 is a correcting knob (which may be one or more); it is contemplated thatwristband 501 may be constructed of a circular ring of rigid material for finger artery blood pressure measurement.

The method of arterial blood vessel pressure measurement of the present invention is exemplified below by figures 16, 17 and 18; wherein, P (millivolt) is an electric signal representing a measured blood pressure value, T (second) is a change time of a blood pressure waveform, Pg is a peak value point of the blood pressure, Pz is a pressure middle value of the blood pressure waveform, Pd is a valley value point of the blood pressure waveform, and T01, T02, T03 and T04 are cardiac cycle separation points of the blood pressure waveform.

The invention informs a user whether a measurement result is effective or not, or whether a contact force value of a contact head and a living body is measured by a blood vessel measuring sensor or not, or whether the contact force is in a specified value range, comprises two driving electric signals: the first method is as follows: in the measurement probe constituted by the "elastically stretchable sensor support leg" shown in fig. 3 and 4, the "elastically stretchable sensor support leg" is an average value of the pressures measured by the first and second sensors; the second method is as follows: the continuous time electric signal of the blood pressure lowest value measured by the artery blood vessel measuring pressure sensor or the displacement sensor, as shown in fig. 17, Td in fig. 18 is compared with the preset time electric signal Te and is generated after judgment; if Td ≦ Te within the predetermined electrical time signal range, an electric signal indicating "within the predetermined electrical time signal range" is generated, or if Td > Te is not within the predetermined electrical time signal range, an electric signal indicating "not within the predetermined electrical time signal range" is generated. Therefore, it is necessary to detect the duration Td of the valley electric signal in fig. 17 and 18 and compare the duration Td with a predetermined reference time Te. Wherein, the basic time Te is an artificially established value, and the smaller Te, the higher the accuracy of measuring the diastolic pressure is determined, which should be determined according to the performance and practicality of the hardware circuit in designing and manufacturing, for example, to achieve 1% of the determination and measurement accuracy, for a person with a heartbeat of 50 to 70 times/second, Te is 1/5000 to 1/7000 seconds; to achieve 2% judgment, measurement accuracy, Te 2/5000 to 2/7000 seconds for a person who has a heartbeat of 50 to 70 times/second, and so on. Therefore, the method for judging whether the sensor really measures the diastolic pressure is to determine whether the sensor measures the diastolic pressure by judging whether the duration of the lowest value of the blood pressure data measured by the sensor is within a preset time range. Similarly, the pressure (average value) (electrical signal) measured by the "elastically stretchable sensor support leg" may be used for the determination (fig. 3 and 4).

recording at least one cardiac cycle blood pressure waveform measured by the sensor;

determining the duration Td of the lowest value Pc of the blood pressure data measured by the sensor, and the time from the point a to the point b;

on a convex portion in a blood pressure waveform measured by a sensor, finding a same-amplitude Px (note that Px is determined by Td, and Px varies with the variation of Px) from a duration Td of a lowest value Pc of blood pressure data measured by the sensor, the duration being the same as the duration Td of the lowest value Pc of the blood pressure data measured by the sensor, a constant-amplitude time line Tdx having a start point and an end point on the convex portion in the blood pressure waveform measured by the sensor, wherein Td is Tdx, c is a time to d, and determining a vertical line data value Pj of the constant-amplitude time line Tdx to a blood pressure waveform peak point Pg, thereby,

the value of the difference between the lowest value Pc of the blood pressure waveform measured by the sensor and the vertical line data value Pj of the blood pressure waveform peak point Pg on the constant amplitude time connecting line Tdx is the diastolic pressure value; namely: the diastolic blood pressure value is Pc-Pj.

The invention provides another method for determining diastolic blood pressure data by contacting a sensor with the skin surface of an adjacent artery of a living body, which comprises the following steps:

determining a duration of a lowest value of the blood pressure data measured by the sensor;

on the convex part in the blood pressure waveform measured by the sensor, finding a constant amplitude time connecting line Tdx with the same amplitude and the same duration as the duration Td of the lowest value Pc of the blood pressure data measured by the sensor according to the duration Td of the lowest value Pc of the blood pressure data measured by the sensor, wherein the starting point and the ending point are on the convex part in the blood pressure waveform measured by the sensor, Tdx is the time Tdx, and the time from c point to d point is determined, and determining a vertical line data value Pj from the constant amplitude time connecting line Tdx to a blood pressure waveform peak point Pg;

correcting a vertical line data value Pj from the amplitude time connecting line Tdx to a blood pressure waveform peak point Pg by a correction coefficient K, namely PgxK; or, the correction of the vertical line data value Pj from the amplitude time connecting line Tdx to the blood pressure waveform peak point Pg is achieved by correcting the amplitude time connecting line Tdx length (time value) through the correction coefficient K, namely, the amplitude time connecting line Tdx K is equal to the correction of the blood pressure waveform peak point Pj; the value of the difference between the lowest value Pc of the blood pressure waveform measured by the sensor and the convex part in the blood pressure waveform, the data value Pg multiplied by K after the data value Pg of the vertical line connecting the constant amplitude time line Tdx to the peak point of the blood pressure waveform is corrected by the correction coefficient is the diastolic pressure value, namely: pc- (PgxK), PgxK < Pc; or,

on the lowest value Pc of the blood pressure waveform measured by the sensor and the convex part in the blood pressure waveform, the value Pc-Pg of the difference between the data values of the vertical lines from the constant amplitude time connecting line Tdx to the peak value Pg of the blood pressure waveform is corrected by a correction coefficient K, and the corrected value is the diastolic pressure value: diastolic pressure (Pc-Pg) × K.

Wherein K is a constant, such as: 0.5, 0.8, 1.2, 2.3, etc. According to practical decisions, it is related to the cardiac cycle of a living subject, the measurement site, the subject's arterial blood pressure waveform, such as: unlike the arterial blood pressure waveform of fig. 16, the correction coefficient K is different when the cardiac cycle of the living body is the same.

The blood pressure detection device of the invention is corrected before application (by adjusting the gain of the amplifier or adjusting the value of the correction coefficient K) to make the reading identical with the actual blood pressure value; the correction value may use a cuff sphygmomanometer, a mercury sphygmomanometer, or the like. Generally, for a fixed user, if a substantially stable fixing force (pressure) is used, the fixed part needs to be corrected only once and then does not need to be corrected again, and the error of the measurement result is not too large. For the user, it is possible to sense and determine the pressure by pressing the user, for example, until the user can not compress the skin. Of course, as shown in fig. 3 and 4, the corrected electric signal of the pressure value (or average value) of the "elastically stretchable sensor supporting foot" may be recorded, and then used as a calibration reference for the user.

In the present invention, the correction by the "correction factor" is to enlarge or reduce the numerical value thereof, and any correction or correction method satisfying the enlargement or reduction is included in the present invention.

In the present invention, the calculation of various numerical values can be performed by hardware circuits, or can be performed by hardware plus software.

FIG. 19 is an exemplary schematic circuit diagram for measuring blood pressure and pulse rate monitoring for the arterial blood vessel probe of FIGS. 1 and 2; theprobe 801 is an arterial blood vessel measuring probe of the present invention, VREV is a reference voltage, 802 is an operational amplifier, W is a gain adjustment potentiometer, 803 is a peak detection holding circuit, 804 is a valley detection holding circuit, 805, 806 are a/D analog-to-digital conversion circuits, 809 is a valley pulse width detector, 803 is a basic valley pulse width signal generator, 810 is a pulse width discriminator, 807, 808, 809 are LCD displays.

FIG. 20 is an exemplary schematic circuit diagram of another embodiment of the arterial blood measurement probe of FIGS. 1 and 2 for measuring blood pressure and pulse rate monitoring; wherein 901 is the artery blood vessel measuring probe of the invention, VREV is the reference voltage, 902 is the operational amplifier, W is the gain adjustment potentiometer, 903 is the A/D analog-to-digital conversion circuit, 904 is the microprocessor, finish the comparison, calculation of various numerical values of the invention, 905 is the power supply, 906 is the memorizer, store the computer code and calculation method of the method stated in the invention, 907 is the sounder, tell the user whether the measurement is effective, 908 is the display, tell the user the measuring result, remind the user of the effectiveness measured.

FIG. 21 is an exemplary schematic circuit diagram of another embodiment of the arterial blood vessel probe of FIGS. 3 and 4 for measuring blood pressure and pulse rate monitoring; wherein 1003 is the artery blood vessel measuring probe of the invention, VREV is the reference voltage, 1006 is the operational amplifier, W is the gain adjustment potentiometer, 1009 is the A/D analog-to-digital conversion circuit; wherein 1001 and 1002 are the 'elastically stretchable sensor support feet' of the present invention, VREV is the reference voltage, 1004 and 105 are operational amplifiers, W is the gain adjustment potentiometer, 1007 is the addition and averaging circuit, 1008 is the A/D analog-to-digital conversion circuit; 1011 is a microprocessor which is used for comparing and calculating various numerical values in the invention, 1010 is a power supply, 1012 is a memory which is used for storing computer codes and a calculation method of the method in the invention, 1013 is a sounder which is used for informing a user whether the measurement is effective, 1014 is a display which is used for informing the user of a measurement result and reminding the user of the effectiveness of the measurement.

Note that: in the invention, the invention can be realized when the blood vessel measuring sensor measuring contact can measure the peak value and the valley value of the blood pressure. The present invention can also be implemented when the blood vessel measurement sensor measurement probe cannot measure the peak and valley points of the blood pressure, however, the valley (minimum) of the blood pressure waveform detected by the blood vessel measurement sensor measurement probe should satisfy: a blood pressure bottom value (minimum value) is within a range of a blood pressure value Pf2 (points z to d) which is equal to or less than a blood pressure value Pf from the middle value Pz to a blood pressure value Pf1 (points g to z) within the inflection wave; namely: as shown in fig. 16, the range of the valley value (minimum value) that can be measured by the blood vessel measurement sensor is Pf2 (point z to d), where Pf2 is Pf 1.

It should be appreciated that the measurement probe, blood pressure determination method, described in the present invention may be applied to provide additional context for various aspects of the present invention. Including handheld communication devices, for example: cell phones, GPRS devices, GPS satellite (navigation) devices, etc.; the cardiovascular health status data of blood pressure, pulse rate, blood vessel hardness and the like detected by the user are sent to a medical center database and handheld communication equipment of doctors and family members to inform the users of the personal cardiovascular health status, which is quite beneficial and necessary for the elderly hypertension patients. Or a personal digital assistant to establish the personal cardiovascular health status file of the user, diagnose diseases, and the like.

FIG. 22 is a schematic block diagram of a communications environment of the present invention; including one or more clients, which may be hardware and/or software (e.g., measurement probes, calculations, threads, processes, communications devices), and one or more servers 1103, which may be hardware and/or software (e.g., threads, processes, calculations, communications devices). One possible communication between a client 1101 and a server can be in the form of a data packet adapted to be transmitted between two or more computers; among other things, a communication framework 1105 can be employed to facilitate communications between the client 1101 and the server 1103, the client 1101 operatively coupled to one or more client data store(s) 1102 that can be employed to store information local to the client 1101, and the server 1103 operatively coupled to one or more server data store(s) 1104 that can be employed to store information local to the server 1103.

The method for judging whether the sensor measures the diastolic pressure or not; a method of determining diastolic blood pressure data; the machine readable computer code or operational computer code or control program may be encoded or otherwise produced in a machine readable medium, such as: CD-ROM, Digital Versatile Disks (DVD), RAM, ROM, EEPROM, flash memory, removable hard disks, magnetic disks (floppy disks), fixed hard disks, etc.; furthermore, detecting the characteristic parameters of the blood vessel of the living body by a measuring probe and inputting the parameters can provide additional relevant environments for various aspects of the invention, comprising the following steps: single-processor or multiprocessor computer systems, microcomputer systems, mainframe computer systems, personal computers, hand-held computing devices, microprocessor-based or programmable electronic devices, and the like; and digital, analog, etc. devices to enable detection, determination, and recording of cardiovascular health conditions.

Meanwhile, it should also be understood that the measurement probe, the method of determining whether the sensor measures the diastolic pressure, and the method of determining the diastolic pressure of the present invention may be implemented in one apparatus at the same time, or may be implemented in different apparatuses, respectively, to improve some of the disadvantages of the existing apparatuses, for example. Application No.: 01820020.6, name: improvements in sensor measurement contacts in "methods and apparatus for monitoring blood pressure"; in US patent document US5,485,848, it is judged whether the sensor has measured the diastolic pressure, and how to measure the diastolic pressure when the sensor has not measured the diastolic pressure, and so on; and other pulse, arteriovascular sclerosis parameters, arteriovascular elasticity parameters, modifications of the measuring probe of the blood flow measuring device, etc.

It should be understood that its measurement probe may be applied to a (finger) ring type blood pressure measuring device; the volume blood pressure measuring device includes a necklace (portable) blood pressure and pulse rate measuring device. The supporting feet of the invention can be 1 to a plurality.

The detection of the blood vessel of the invention comprises the following steps: extra arteries, common carotid arteries, subclavian arteries, axillary arteries, brachial arteries, femoral arteries, ulnar arteries, radial arteries, etc. of a living body (e.g., a human body); the method can be applied to measuring, judging and calculating the physical characteristic parameters of the artery blood vessels by contacting the artery blood vessel sensor with the surface of the artery blood vessels (skin) adjacent to a living body and measuring the blood vessel pressure of the living body. Of course, the present invention includes the detection of blood vessels in animals.

The foregoing is illustrative of the present invention and is not intended to fully describe the conceivable combinations, permutations, and application of the methods, alternatives, and so forth; it is intended that the invention cover all such modifications and variations as fall within the spirit and scope of the appended claims. For example: according to the method for determining and calculating the diastolic pressure, the waveform of the diastolic pressure which cannot be detected is determined and calculated; so that a complete blood pressure waveform of the blood vessel is synthesized by a vector synthesis method, thereby displaying the blood pressure waveform, and the like.

Claims

1. A measuring probe for measuring a physical characteristic parameter of a vascular system of a living body by bringing a sensor into contact with a skin surface of an adjacent artery of the living body, characterized in that: the method comprises the following steps:

a bracket with a supporting foot is provided,

the measuring feeler may be an elastically telescopic pressure sensor, or, alternatively, a displacement sensor,

the measuring contact can be an elastic telescopic pressure sensor or a displacement sensor which is arranged on the bracket,

the measuring contact is towards the direction of the support foot.

2. A measuring probe for measuring a physical characteristic parameter of a vascular system of a living body by bringing a sensor into contact with a skin surface of an adjacent artery of the living body, characterized in that: the method comprises the following steps:

the measuring contact can be an elastic telescopic pressure sensor, or a displacement sensor supporting foot,

the measuring contacts may be an elastically telescopic vascular measuring pressure sensor, or, alternatively, a displacement sensor,

the measuring contact can be an elastic telescopic pressure sensor, or the supporting leg of the displacement sensor and the measuring contact can be an elastic telescopic blood vessel measuring pressure sensor, or the measuring contact of the displacement sensor faces the direction of the support leg.

3. A method for determining whether a sensor measures diastolic pressure by contacting the sensor with a skin surface of an artery adjacent to a living body, the method comprising: whether the sensor measures the diastolic pressure is determined by determining whether the duration of the lowest value of the blood pressure data measured by the sensor is within a predetermined time range.

4. The method of claim 3, wherein: comprises the following steps:

the duration of the lowest value of the blood pressure data measured by the sensor is within a predetermined time range, and the lowest value of the blood pressure data measured by the sensor is the diastolic blood pressure value, or,

if the duration of the lowest value of the blood pressure data measured by the sensor is not within the predetermined time range, the lowest value of the blood pressure data measured by the sensor is not the diastolic blood pressure value.

5. A method for determining diastolic blood pressure data by contacting a sensor with a skin surface of a living subject adjacent an arterial vessel, the method comprising: the method comprises the following steps:

the value of the difference between the lowest value of the blood pressure waveform measured by the sensor and the data value of the vertical line connecting the constant amplitude time to the peak point of the blood pressure waveform on the convex part of the blood pressure waveform is the diastolic pressure value.

6. A method for determining diastolic blood pressure data by contacting a sensor with a skin surface of a living subject adjacent an arterial vessel, the method comprising: the method comprises the following steps:

7. A machine-readable, or otherwise operable, storage medium, characterized by: machine readable computer code or operable computer code or control program recording at least one of the methods of claims 3, 4, 5 or 6.

8. A measuring apparatus for measuring a blood pressure of a living body by bringing a sensor into contact with a skin surface of an artery adjacent to the living body, the measuring apparatus being constituted by a pressure sensor portion, or a displacement sensor portion, an electric signal processing portion, a display portion, and the like, characterized in that: comprises the following steps:

a display section including: reminding the user whether the measurement result is valid or not when the measurement is judged, or informing the user of the contact force value of the measurement contact of the blood vessel measurement sensor and the living body, or whether the contact force is in at least one of visual information such as letters, symbols, figures, numbers and the like in a specified value range or not, or,

a measurement device, comprising: and the sound device is used for reminding the user whether the measurement result is valid or not when the user judges the measurement, or informing the user of the contact force value between the measurement contact of the blood vessel measurement sensor and the living body or whether the contact force is within a specified value range or not.

9. A handheld communication device, or personal digital assistant, characterized by: use of a measurement probe according to claim 1, or 2.

10. A handheld communication device, or personal digital assistant, characterized by: machine readable computer code or operable computer code or control program in a storage medium using at least one of the methods of claims 3, 4, 5, 6.