Patch pumpTechnical Field
The invention belongs to the technical field of drug delivery, and particularly relates to a patch pump.
Background
The subcutaneous injection of the medicine is generally performed slowly by using a common injector, and with the development of medical technology, the dosage of the subcutaneous injection medicine is larger and can reach 25ml at maximum, and the common injector is difficult to meet the requirement. Patch pumps are advanced subcutaneous administration devices that can be adapted for large-dose subcutaneous injections.
Patch pumps are commonly used for continuous infusion of insulin for the treatment of diabetics and may also be used for the delivery of other types of medication. The patch pump is designed to be directly attached to the skin, to inject the drug directly into the subcutaneous tissue through a small catheter, and to install a power source to drive the drug injection system. For example, the prior art publication number is CN107847666B, a sterile patch pump is provided, a drug injection system is powered by a hydrogen generator in a pressurizing system, and the hydrogen generator is provided with a corresponding control device. The existing patch pump is generally provided with a power source and a corresponding control device, and along with the increase of the dosage of the subcutaneous injection medicine, the overall weight of the patch pump is large, and the patch pump is inconvenient to be stuck on the skin surface for injection. There is therefore a need for a new patch pump.
Disclosure of Invention
In order to solve the problems, the invention discloses a patch pump.
In order to achieve the above purpose, the technical scheme of the invention is as follows:
A patch pump comprises a double-sided adhesive tape, wherein an upper cover is fixedly connected to one side of the double-sided adhesive tape, a medicine bag component is clamped between the upper cover and the double-sided adhesive tape, one end of the medicine bag component is communicated with a medicine inlet valve, the other end of the medicine inlet valve is communicated with a needle inlet component linked with the medicine bag component, medicine liquid is stored in the medicine bag component, the needle inlet component adjusts the flow passage sectional area of the medicine liquid according to the medicine feeding pressure change of the medicine bag component, and the medicine feeding flow of the medicine liquid passing through the needle inlet component is stable.
As a preferable technical scheme of the invention, the medicine bag component comprises a medicine bag lower shell and a medicine bag upper shell which are spliced together, a medicine bag central tube is arranged in a storage cavity formed between the medicine bag lower shell and the medicine bag upper shell, one end of the medicine bag central tube is communicated with a medicine inlet valve through a hose, the outer wall of the medicine bag central tube is elastically wrapped with an elastic medicine bag, two ends of the elastic medicine bag are fixed with the outer wall of the medicine bag central tube in a sealing manner, the inner cavity of the medicine bag central tube is communicated with the elastic medicine bag through a plurality of uniformly distributed through holes on the medicine bag central tube, and the medicine bag lower shell and the medicine bag upper shell are transversely and slidingly connected with a flow regulating push rod.
As a preferable technical scheme of the invention, two ends of the elastic medicine bag are respectively and elastically sleeved with a medicine bag fixing ring, and the two medicine bag fixing rings are respectively attached to the inner walls of the lower medicine bag shell and the upper medicine bag shell.
As a preferable technical scheme of the invention, the upper shell of the medicine bag is made of transparent material, and the upper cover is provided with a through hole exposing the upper shell of the medicine bag.
As an optimized technical scheme, the needle inlet assembly comprises an annular needle inserting device shell which is clamped in a flat through hole of a lower shell of a medicine bag, wherein the inner wall of the needle inserting device shell is connected with a liquid path adapter in an up-down limiting sliding manner, a sealing plug is embedded in an opening at the top of the liquid path adapter, an introducing needle is inserted in the sealing plug, a soft needle extends from a through hole at the bottom of the liquid path adapter, the introducing needle is inserted into a central hole of the soft needle in a sliding manner, a transverse branch pipe of the liquid path adapter is communicated with a medicine inlet valve through a hose, an adjusting valve core coaxial with the transverse branch pipe of the liquid path adapter is connected with the transverse branch pipe in a sliding manner, a conical head part of the adjusting valve core is inserted into the transverse branch pipe of the liquid path adapter, the adjusting valve core is always clung to a flow adjusting push rod, a spring in a compressed state is sleeved outside an extending pipe of the liquid path adapter, and the other end of the spring props against a side plate of the adjusting valve core.
As a preferred technical scheme of the invention, the annular wall of the pin inserting device shell is extended with at least two elastic extension pieces, initial clamping grooves of all the elastic extension pieces are clamped with the bottom extension ring of the liquid path adapter together, the initial clamping grooves are provided with chamfer angles which are adapted to guide the liquid path adapter to move downwards, and the bottom extension ring of the liquid path adapter is clamped when moving to the lower part of the elastic extension pieces.
As a preferable technical scheme of the invention, the top of the liquid path adapter is clamped with the pin ring, the top of the pin ring is clamped with the pin device handle, and the pin device handle is fixedly connected with the guide pin.
As a preferable technical scheme of the invention, the guide needle is penetrated with a safety protection block in a sliding way, the safety protection block is fixedly clamped into a notch at the top of the liquid path adapter, the guide needle is elastically clamped at the top of the safety protection block, and the guide needle is provided with a notch which is matched with the elastic clamping of the safety protection block.
As a preferable technical scheme of the invention, the regulating valve core is provided with a notch adapted to the guide-in needle, the middle part of the regulating valve core is sleeved with a sealing ring, and the sealing ring is attached to the inner wall of the extension pipe of the liquid path adapter.
As a preferable technical scheme of the invention, the bottom of the medicine inlet valve is clamped in the through hole of the lower shell flat plate of the medicine bag, the medicine inlet rubber plug is embedded at the bottom opening of the medicine inlet valve, and the double-sided rubber is provided with the through hole exposing the medicine inlet rubber plug.
The beneficial effects of the invention are as follows:
1. The patch pump provides injection power through the elastic medicine bag, does not need an additional power device, has a simple and compact structure and light weight, wherein the automatic adjusting device can adjust the sectional area of a flow passage according to the injection pressure of the elastic medicine bag, ensures the relatively stable injection rate of medicine, and realizes relatively stable and slow subcutaneous injection;
2. when part of patch pumps store liquid medicine, the piston pumps need to be smeared with silicone oil between the pistons and the medicine cartridges for lubrication, and the silicone oil can influence the medicine performance to a certain extent;
3. The patch pump guide needle is provided with the safety device, and the safety device can ensure that the needle point is not exposed outside after the guide needle is pulled out, so that the probability of the needle point stabbing human body is reduced.
Drawings
FIG. 1 is a schematic diagram of the overall structure of an embodiment of the present invention;
FIG. 2 is a schematic view of the overall structure of another embodiment of the present invention;
FIG. 3 is an overall exploded view of an embodiment of the present invention;
FIG. 4 is an exploded view of an embodiment of the present invention of the needle assembly, drug access valve, drug bladder assembly and hose;
FIG. 5 is a cross-sectional view of a central tube and an elastic balloon of an embodiment of the present invention;
FIG. 6 is a cross-sectional view of an embodiment of the needle assembly of the present invention;
FIG. 7 is a schematic view of the structure of an introducer needle and a safety block according to an embodiment of the invention;
FIG. 8 is a partial cross-sectional view of a pin keeper housing and a fluid path adapter according to an embodiment of the present invention;
FIG. 9 is a schematic view of a housing of a pin keeper according to an embodiment of the present invention;
fig. 10 is a schematic structural diagram of an inlet valve according to an embodiment of the present invention.
List of drawing identifiers:
1. An upper cover;
2. Needle insertion assembly, needle insertion device shell, 201a, elastic extension piece, 201b, initial clamping groove, 202, needle insertion ring, 203, needle insertion device handle, 204, leading-in needle, 205, safety protection block, 206, liquid path adapter, 207, sealing plug, 208, soft needle, 209, adjusting valve core, 210, sealing ring, 211, spring;
3. a medicine feeding valve 301, a medicine feeding rubber plug;
4. a drug sac assembly; 401, a lower shell of the medicine bag, 402, an upper shell of the medicine bag, 403, a fixed ring of the medicine bag, 404, a central tube of the medicine bag, 405, an elastic medicine bag, 406, and a flow regulating push rod;
5. double faced adhesive tape;
6. And (3) a hose.
Detailed Description
The present invention is further illustrated in the following drawings and detailed description, which are to be understood as being merely illustrative of the invention and not limiting the scope of the invention.
Referring to fig. 1-10, a patch pump includes a double sided tape 5, and an upper cover 1 is fixedly connected to one side of the double sided tape 5. The double faced adhesive tape 5 is used for fixing the patch pump on human skin, and the upper cover 1 is used for dust prevention and beautifying the appearance. A medicine bag component 4 is clamped between the upper cover 1 and the double faced adhesive tape 5, one end of the medicine bag component 4 is communicated with a medicine inlet valve 3, and the other end of the medicine inlet valve 3 is communicated with a needle inlet component 2 which is linked with the medicine bag component 4. The medicine bag component 4 is internally provided with medicine liquid, the needle inlet component 2 adjusts the flow passage sectional area of the medicine liquid according to the medicine feeding pressure change of the medicine bag component 4, and the medicine feeding flow rate of the medicine liquid through the needle inlet component 2 is stable. The needle assembly 2 is used to insert an injection needle into a human body to create a passageway between the elastomeric bladder 405 and the skin of the human body. The medicine bag assembly 4 is used for storing medicine and providing injection power. The needle assembly 2 is mounted centrally in the sachet assembly 4.
The medicine bag component 4 comprises a medicine bag lower shell 401 and a medicine bag upper shell 402 which are spliced together, a medicine bag central tube 404 is arranged in a storage cavity formed between the medicine bag lower shell 401 and the medicine bag upper shell 402, and one end of the medicine bag central tube 404 is communicated with the medicine inlet valve 3 through a hose 6. The outer wall of the medicine bag central tube 404 is elastically wrapped with an elastic medicine bag 405, two ends of the elastic medicine bag 405 are fixed with the outer wall of the medicine bag central tube 404 in a sealing way, and the inner cavity of the medicine bag central tube 404 is communicated with the elastic medicine bag 405 through a plurality of evenly distributed through holes on the medicine bag central tube 404. The lower capsule shell 401 and the upper capsule shell 402 together form a reservoir that limits the inflated profile of the elastomeric capsule 405. The medicine bag central tube 404 supports the elastic medicine bag 405, and the medicine liquid enters the elastic medicine bag 405 from the medicine inlet valve 3 through the medicine bag central tube 404, so that the elastic medicine bag 405 is inflated to store the medicine liquid, and in the injection process, the medicine liquid can return to the inner cavity of the medicine inlet valve 3 from the elastic medicine bag 405 and enter the needle inlet assembly 2 through the other branch tube of the medicine inlet valve 3, and finally the medicine liquid is injected into a human body through the needle inlet assembly 2.
The lower medicine bag shell 401 and the upper medicine bag shell 402 are connected with a flow adjusting push rod 406 in a transverse sliding mode. The flow regulating push rod 406 is always clung to the elastic medicine bag 405, the elastic medicine bag 405 expands after being charged, the flow regulating push rod 406 is pushed to move, the regulating valve core 209 is driven to regulate the flow, the regulating valve core 209 is pushed by the spring 211 to ensure that the regulating valve core 209 is clung to the flow regulating push rod 406, and further the flow regulating push rod 406 is clung to the elastic medicine bag 405.
The elastic medicine bag 405 can be provided with several types, such as 5ml, 10ml, 25ml, etc., and the first function is medicine storage function, and the second function can provide the power source for injection (through the elasticity of the elastomer). The shape of the elastic medicine bag 405 can be set into various shapes, the elastic medicine bag 405 is annular in the embodiment of the application, the elastic medicine bag 405 surrounds the needle assembly 2, and the medicine inlet valve 3 is arranged at the notch of the elastic medicine bag 405. The inner wall of the elastic medicine bag 405 is stretched by the medicine bag central tube 404 during assembly, so that the elastic medicine bag 405 has a pretightening force, the pretightening force ensures that the elastic medicine bag 405 is tightly attached to the medicine bag central tube 404, and the design has the advantage of reducing the residual quantity of the medicine liquid in the elastic medicine bag 405. The injection time of the liquid medicine with different capacities is different, the whole injection time is generally about 5-45 minutes, and the requirements of different injection time can be met by selecting materials with different elasticity and thicknesses to manufacture the elastic saccule.
Two ends of the elastic medicine bag 405 are respectively and elastically sleeved with a medicine bag fixing ring 403, and the two medicine bag fixing rings 403 are respectively attached to the inner walls of the medicine bag lower shell 401 and the medicine bag upper shell 402. In the embodiment of the application, two ends of the elastic medicine bag 405 and the medicine bag central tube 404 are pressed and fixed by two medicine bag fixing rings 403 to form a seal, and the seal fixation can also be realized by other modes, such as glue bonding, binding and the like.
The upper casing 402 of the medicine bag is made of transparent material, and the upper cover 1 is provided with a through hole exposing the upper casing 402 of the medicine bag, so that a user can see the filling condition (empty/full) of the medicine in the elastic medicine bag 405.
The needle insertion assembly 2 comprises an annular needle inserter housing 201 which is clamped in a flat through hole of a lower medicine bag housing 401. The inner wall of the pin device housing 201 is slidably connected with a liquid path adapter 206 in an up-and-down limited manner, wherein the liquid path adapter 206 is at an initial position when sliding to the top, and the liquid path adapter 206 is at an injection position when sliding to the bottom. A sealing plug 207 is embedded in the opening at the top of the liquid path adapter 206, and an introduction needle 204 is inserted in the sealing plug 207. The sealing plug 207 is pulled out of the introducer needle 204, and the passageway left by the introducer needle 204 is closed. The bottom through hole of the fluid path adapter 206 is extended with a soft needle 208, and the introduction needle 204 is slidably inserted into the center hole of the soft needle 208. With the soft needle 208 inserted into the introducer needle 204, the passageway between the lumen of the fluid pathway adapter 206 and the skin is closed. The lateral branch pipe of the liquid path adapter 206 is communicated with the medicine inlet valve 3 through the hose 6, and the liquid path adapter 206 is transversely connected with an adjusting valve core 209 coaxial with the lateral branch pipe in a sliding manner. The tapered head portion of the regulator valve core 209 is inserted into the lateral leg of the hydraulic adapter 206, and the regulator valve core 209 is always in close proximity to the flow regulator pushrod 406. As the regulator spool 209 moves, the degree to which its conical head is inserted into the lateral leg of the hydraulic adapter 206 changes, causing the cross-sectional area of the flow passage within the lateral leg to change. The extension pipe of the hydraulic adapter 206 is sleeved with a spring 211 in a compressed state all the time, and the other end of the spring 211 abuts against the side plate of the regulating valve core 209.
The conical head design of the regulating valve core 209 (other similar cross-sectional area gradual change designs are also applicable) regulates the liquid medicine flow entering the human body in unit time under the movement of the flow regulating push rod 406.
The annular wall of the pin keeper housing 201 extends with at least two resilient extension tabs 201a, with the initial snap-in slots 201b of all resilient extension tabs 201a collectively snap-in to the bottom extension ring of the fluid circuit adapter 206. The initial clamping groove 201b is provided with a chamfer adapted to guide the downward movement of the liquid path adapter 206, and the bottom extension ring of the liquid path adapter 206 is clamped when it moves under the elastic extension piece 201 a. When the initial clamping groove 201b clamps the bottom extension ring of the liquid path adapter 206, the liquid path adapter 206 is at the initial position, and when the bottom extension ring of the liquid path adapter 206 moves below the elastic extension piece 201a, the liquid path adapter 206 is at the injection position.
The top of the liquid path adapter 206 is clamped with a pin ring 202, the top of the pin ring 202 is clamped with a pin device handle 203, and the pin device handle 203 is fixedly connected with an introduction needle 204. The fixing between the pin ring 202 and the liquid path adapter 206 is tight and difficult to pull open easily, and the connection between the pin ring 202 and the pin device handle 203 can be pulled open easily by a certain pulling force. The needle inserter handle 203 and the introducer needle 204 are secured by an interference fit or adhesive. Pressing the needle inserter handle 203, the leading-in needle 204 moves downwards, the soft needle 208 is driven to be inserted into a human body, and after the soft needle 208 is in place, the needle inserter handle 203 is pulled out together with the leading-in needle 204 and the safety protection block 205.
The leading-in needle 204 is penetrated with a safety protection block 205 in a sliding way, and the safety protection block 205 is fixedly clamped into a notch at the top of the liquid path adapter 206. The top of the safety protection block 205 elastically clamps the lead-in needle 204, and the lead-in needle 204 is provided with a notch which is matched with the elastic clamping of the safety protection block 205. The safety protection block 205 is fixed on the liquid path adapter 206, wherein the safety protection block 205 is designed with two elastic extension sheets, the liquid path adapter 206 is provided with a notch corresponding to the extension sheets, the safety protection block 205 is fixed by compressing the two elastic extension sheets through the notch, and a certain external force can pull the safety protection block 205 to be separated from the notch of the liquid path adapter 206. In the actual use process, a notch is formed in the guide needle 204, the guide needle 204 is clamped at the top slit of the safety protection block 205 in an elastic sliding manner, when the guide needle 204 is pulled out, the guide needle 204 moves relative to the safety protection block 205, the notch of the guide needle 204 is clamped by the elastic bayonet of the safety protection block 205 when the guide needle 204 moves to a certain position, the guide needle 204 cannot slide, the needle point is fixed in the protection cavity of the safety protection block 205, and any part of a finger and a human body cannot touch the needle point, so that the human body is prevented from being stabbed.
The adjusting valve core 209 is provided with a notch adapted to the guide-in needle 204, a sealing ring 210 is sleeved in the middle of the adjusting valve core 209, and the sealing ring 210 is attached to the inner wall of the extension pipe of the liquid path adapter 206 so as to enhance the tightness of the inner cavity of the liquid path adapter 206.
The bottom of the medicine inlet valve 3 is clamped in a through hole of a flat plate of the lower medicine bag shell 401, a medicine inlet rubber plug 301 is embedded at the bottom opening of the medicine inlet valve 3, and a through hole exposing the medicine inlet rubber plug 301 is formed in the double faced adhesive tape 5. The medicine feeding rubber plug 301 is used for the needle to pierce the injected medicine liquid, and the channel left by the needle is closed after the needle is pulled out.
Principle of operation
Before the patch pump is used, the injector is filled with medicine liquid, the medicine liquid is penetrated through the medicine inlet rubber plug 301 of the medicine inlet valve 3, after the medicine liquid is injected into the medicine inlet valve 3, the medicine liquid enters the elastic medicine bag 405 through the connected medicine bag central tube 404, the elastic medicine bag 405 expands and stores the medicine liquid under the action of the medicine liquid pressure, and the medicine bag lower shell 401 and the medicine bag upper shell 402 limit the appearance of the elastic medicine bag 405;
When the patch pump is used, firstly, the double-sided tape 5 cover layer is torn off, then the patch pump is applied on the skin (generally abdomen and thigh) of a human body, the needle inserting device handle 203 is pressed, the soft needle 208 is driven by the leading-in needle 204 to pierce the skin of the human body in the process, then the needle inserting device handle 203 is pulled out, the leading-in needle 204 is carried out by the needle inserting device handle 203, a channel between the inner cavity of the liquid channel adapter 206 and the skin of the human body is constructed, and the liquid medicine is slowly injected into the skin of the human body under the pressure of the elastic medicine bag 405;
Because the adjusting valve core 209 is always clung to the flow adjusting push rod 406, in the injection process of the liquid medicine, the injection pressure of the elastic medicine bag 405 is the largest at the beginning, the conical head of the adjusting valve core 209 is inserted into the depth of the transverse branch pipe of the liquid path adapter 206 to be the deepest, the flow passage sectional area in the transverse branch pipe is the smallest at the moment, the elastic medicine bag 405 is contracted along with the injection, the injection pressure is gradually reduced, the adjusting valve core 209 moves along with the flow adjusting push rod 406, the conical head of the adjusting valve core 209 is inserted into the depth of the transverse branch pipe of the liquid path adapter 206 to be reduced, the flow passage sectional area in the transverse branch pipe is gradually increased, the liquid medicine quantity injected in unit time is relatively stable, and the liquid medicine injection rate is relatively stable in the whole injection process is ensured.
It should be noted that the foregoing merely illustrates the technical idea of the present invention and is not intended to limit the scope of the present invention, and that a person skilled in the art may make several improvements and modifications without departing from the principles of the present invention, which fall within the scope of the claims of the present invention.