Disclosure of Invention
Based on the problems, the invention provides a hydrogel wound dressing containing nano cuttlebones. The hydrogel wound dressing containing nano cuttlebone has a lasting hemostatic effect, and is beneficial to widening the development of the use of the wound dressing.
In order to achieve the above purpose, the present invention adopts the following technical scheme:
The hydrogel wound dressing comprises a dressing main body, wherein the dressing main body is provided with a dressing surface and a separation surface opposite to the dressing surface, the dressing surface is used for covering a wound, the separation surface is used for separating contact between the environment and the wound, the dressing main body comprises a first hydrogel framework and a second hydrogel framework which are arranged in a stacked mode along the direction from the dressing surface to the separation surface, first nano cuttlebone powder is distributed in the first hydrogel framework, second nano cuttlebone powder is distributed in the second hydrogel framework, and the particle size of the first nano cuttlebone powder is larger than that of the second nano cuttlebone powder.
In some embodiments, the particle size of the first nano cuttlebone powder is 200 nm-400 nm, and the particle size of the second nano cuttlebone powder is 50 nm-100 nm.
In some embodiments, the first nano cuttlebone powder comprises a greater mass percentage of the first hydrogel scaffold than the second nano cuttlebone powder comprises a mass percentage of the second hydrogel scaffold.
In some embodiments, the first nano cuttlebone powder accounts for 5% -15% of the mass of the first hydrogel skeleton, and the second nano cuttlebone powder accounts for 2% -10% of the mass of the second hydrogel skeleton.
In some of these embodiments, the thickness of the first hydrogel scaffold is greater than the thickness of the second hydrogel scaffold.
In some embodiments, the thickness of the first hydrogel framework is 0.3 mm-2 mm, and the thickness of the second hydrogel framework is 0.2 mm-1.5 mm.
In some embodiments, the first hydrogel framework comprises a first hydrophilic polymer material and a first cross-linking agent, wherein the first hydrophilic polymer material comprises sodium alginate, and the first cross-linking agent comprises calcium chloride;
The second hydrogel framework contains a second hydrophilic polymer material and a second crosslinking agent, wherein the second hydrophilic polymer material comprises one or more of polyacrylamide and polyvinyl alcohol, and the second crosslinking agent comprises glutaraldehyde.
In some embodiments, the first cross-linking agent accounts for 1% -5% of the mass of the first hydrogel skeleton, and the second cross-linking agent accounts for 0.1% -1% of the mass of the second hydrogel skeleton.
In some embodiments, the hydrogel wound dressing comprising nano-cuttlebone further comprises a waterproof and breathable membrane, wherein the waterproof and breathable membrane is positioned on the isolation surface, and the material of the waterproof and breathable membrane comprises one or more of polytetrafluoroethylene and polyurethane.
In some embodiments, the hydrogel wound dressing containing nano cuttlebone further comprises a protective film, wherein the protective film is positioned on the dressing surface, and the material of the protective film comprises one or more of polyethylene and polypropylene.
Advantageous effects
The hydrogel wound dressing of the present invention includes a dressing body having an application face and a release face opposite the application face. The dressing surface is for covering the wound and the isolation surface is for isolating contact between the environment and the wound. In the direction along dressing face to the spacer surface, the dressing main part is including range upon range of first hydrogel skeleton and the second hydrogel skeleton that sets up, distributes first nanometer cuttlebone powder in the first hydrogel skeleton, distributes second nanometer cuttlebone powder in the second hydrogel skeleton. The particle size of the first nano cuttlebone powder is larger than that of the second nano cuttlebone powder. When the wound dressing is used, the wound is covered by the dressing surface, and the hydrogel framework has better absorption effect on moisture, so that the dryness of the wound can be kept. Meanwhile, the first nano cuttlebone powder with larger particle size promotes aggregation of blood platelets at a wound, and accelerates the coagulation process. With the prolongation of time, the efficacy of the first nano cuttlebone powder is reduced, and the second nano cuttlebone powder with smaller particle size can be transferred between the particles of the first nano cuttlebone powder, so that fresh cuttlebone with better efficacy is provided, and the coagulation process is further promoted. Therefore, when the hydrogel wound dressing containing nano cuttlebone is adopted, along with the extension of dressing time, the high-efficacy cuttlebone with higher concentration can be maintained at the dressing surface, so that the lasting hemostatic effect is maintained.
Detailed Description
The inventor of the invention finds that hydrogel is a high polymer material with a three-dimensional network structure in the process of researching wound dressing, can absorb a large amount of moisture, keeps the moist environment of the wound and is beneficial to the healing of the wound. Meanwhile, the hydrogel also has good biocompatibility and air permeability, and can reduce the risk of wound infection. But hydrogels have poor hemostatic properties. The cuttlebone has the effects of astringing and stopping bleeding, astringing essence and stopping leukorrhagia, relieving hyperacidity and pain, astringing dampness and healing sore, and the like, and the effective components of the cuttlebone can promote blood coagulation and have good hemostatic effect. The cuttlebone is applied to the wound dressing, so that the hemostatic effect of the dressing can be improved. However, in general, cuttlebone powder has poor dispersibility in a dispersion medium and is easily agglomerated, thereby affecting the exertion of hemostatic effect. If hydrogel and cuttlebone are combined, the hemostatic effect of the wound dressing can be effectively improved.
Based on this, an embodiment of the present invention provides a hydrogel wound dressing containing nano cuttlebone. Referring to fig. 1, a hydrogel wound dressing 100 comprising nano-cuttlebone according to an embodiment of the present invention. The hydrogel wound dressing 100 containing nano cuttlebone comprises a dressing main body 101, wherein the dressing main body 101 is provided with a dressing surface and a separation surface opposite to the dressing surface, the dressing surface is used for covering a wound, the separation surface is used for separating contact between the environment and the wound, the dressing main body 101 comprises a first hydrogel skeleton 1011 and a second hydrogel skeleton 1012 which are arranged in a stacked mode along the direction from the dressing surface to the separation surface, first nano cuttlebone powder 1013 is distributed in the first hydrogel skeleton 1011, second nano cuttlebone powder 1014 is distributed in the second hydrogel skeleton 1012, and the particle size of the first nano cuttlebone powder 1013 is larger than that of the second nano cuttlebone powder 1014.
When the wound dressing of the embodiment is used, the wound is covered by the dressing surface, and the hydrogel framework has better absorption effect on moisture at the moment, so that the dryness of the wound can be kept. Meanwhile, the first nano cuttlebone powder 1013 with larger particle size promotes aggregation of blood platelets at the wound, and accelerates the coagulation process. Over time, the effectiveness of the first nano cuttlebone powder 1013 decreases and the second nano cuttlebone powder 1014 having a smaller particle size can migrate between the particles of the first nano cuttlebone powder 1013, thereby providing fresh cuttlebone with better effectiveness and further promoting the clotting process. Therefore, when the hydrogel wound dressing 100 containing nano cuttlebone is adopted, along with the extension of dressing time, the high-efficacy cuttlebone with higher concentration can be maintained at the dressing surface, so that the lasting hemostatic effect can be maintained.
Further, the nano cuttlebone powder has a good dispersing effect in the hydrogel framework, so that the first nano cuttlebone powder 1013 in the first hydrogel framework 1011 can be uniformly distributed in the first hydrogel framework 1011, and the second nano cuttlebone powder 1014 in the second hydrogel framework 1012 can be uniformly distributed in the second hydrogel framework 1012, thereby being beneficial to fully playing the efficacy of the nano cuttlebone and further improving the hemostatic effect of the hydrogel wound dressing.
In the present invention, cooperative promotion of hemostatic effect is achieved by distributing cuttlebone powder of different particle sizes in the first hydrogel skeleton 1011 and the second hydrogel skeleton 1012. In the initial stage of the wound contact dressing, the first nano cuttlebone powder 1013 with large particle size plays the roles of rapid hemostasis and stable hemostasis, and the second nano cuttlebone powder 1014 with small particle size assists in enhancing the hemostasis effect. After the efficacy of the first nano cuttlebone powder 1013 with large particle size is reduced with the time, the second nano cuttlebone powder 1014 with small particle size can be timely supplemented, and the hemostatic effect is continuously exerted. The synergistic effect ensures that the hydrogel wound dressing containing nano cuttlebone powder with different particle sizes has lasting and efficient hemostatic effect, and provides good conditions for wound healing.
Further, the inventors of the present invention have studied the hydrogel wound dressing 100 containing nano cuttlebone, and have found that the first nano cuttlebone powder 1013 having a large particle size acts first when the wound just contacts the hydrogel wound dressing 100 containing nano cuttlebone. Due to its relatively large particle size, a physical barrier can be rapidly formed at the wound surface. This physical barrier acts like a small "dam" and prevents blood flow. Meanwhile, the surface of the first nano cuttlebone powder 1013 with large particle size can adsorb a large amount of platelets, and the platelets can release coagulation factors after being aggregated on the surface of the platelets, so that the coagulation process is accelerated. In addition, since the particles of the first nano cuttlebone powder 1013 having a large particle size are large, they are not easily washed away by blood. Therefore, the physical barrier formed on the wound surface is relatively stable, and can effectively exert a hemostatic effect in the early stage of the wound.
Further, the second nano cuttlebone powder 1014 with small particle size has small particle size and larger specific surface area. In the initial stage of the wound, the second nano cuttlebone powder 1014 of small particle size may be filled in the gaps between the first nano cuttlebone powder 1013 of large particle size, further enhancing the physical barrier effect. Meanwhile, the second nano cuttlebone powder 1014 with small particle size can adsorb platelets, and the powder with large specific surface area can adsorb more platelets. In addition, the bioactive component contained in the second nano cuttlebone powder 1014 with small particle size can be contacted with and react with the coagulation factors in blood more quickly, and the first nano cuttlebone powder 1013 with large particle size is assisted to accelerate the coagulation speed.
The hemostatic efficacy of the large particle size first nano-cuttlebone powder 1013 gradually decreases over time. On the one hand, the platelets adsorbed on the surface of the first nano cuttlebone powder 1013 having a large particle size may fall off under the scouring and soaking of blood, and the physical barrier effect thereof may be weakened due to abrasion or displacement of the particles. On the other hand, the bioactive ingredient in the first nano cuttlebone powder 1013 having a large particle size is gradually consumed in the continuous coagulation reaction. With the decrease of these active ingredients, the ability to activate the coagulation factors is also decreased, resulting in a slow coagulation process. However, the reduced effectiveness of the large particle size first nano cuttlebone powder 1013 also provides for the small particle size second nano cuttlebone powder 1014 to function. As the gaps between the particles of the first nano cuttlebone powder 1013 of large particle size become larger, the second nano cuttlebone powder 1014 of small particle size can more easily transfer from the second hydrogel skeleton 1012 to between the particles of the first nano cuttlebone powder 1013 in the first hydrogel skeleton 1011, and a better hemostatic effect can be continuously exerted. This dynamic replenishment process ensures that there is always sufficient cuttlebone component at the wound site to promote hemostasis over a longer period of time.
Further, the small-particle-size second nano cuttlebone powder 1014 can penetrate into the tiny gaps of the wound tissue due to the small particle size, fully contact with components in blood, and can continuously adsorb platelets and activate coagulation factors to maintain the coagulation process.
In some embodiments, the particle size of the first nano cuttlebone powder 1013 is 200 nm-400 nm. The particle size of the second nano cuttlebone powder 1014 is 50 nm-100 nm. Alternatively, the particle size of the first nano cuttlebone powder 1013 may be 200nm、210nm、220nm、230nm、240nm、250nm、260nm、270nm、280nm、290nm、300nm、310nm、320nm、330nm、340nm、350nm、360nm、370nm、380nm、390nm、400nm or the like. It is understood that the particle size of the first nano cuttlebone powder 1013 may be selected within a range of 200nm to 400nm. Alternatively, the particle size of the second nano cuttlebone powder 1014 may be 50nm, 60nm, 70nm, 80nm, 90nm, 100nm, etc. It is understood that the particle size of the second nano cuttlebone powder 1014 may be selected within a range of 50nm to 100nm. The particle sizes of the first nano cuttlebone powder 1013 and the second cuttlebone powder are in the corresponding range, so that the first nano cuttlebone powder 1013 and the second cuttlebone powder can be better matched, the second nano cuttlebone powder 1014 can be more timely supplemented between the first nano cuttlebone powder 1013 in the first hydrogel skeleton 1011, and the hemostatic effect of the hydrogel wound dressing is further improved.
In some embodiments, the first nano-cuttlebone powder 1013 comprises a greater mass percentage of the first hydrogel scaffold 1011 than the second nano-cuttlebone powder 1014 comprises a mass percentage of the second hydrogel scaffold 1012. At this time, in the early stage of hemostasis, the wound dressing can provide enough cuttlebone component to promote hemostasis, so that the first nano cuttlebone powder 1013 can fully play a hemostasis role, and a rapid hemostasis effect is obtained. Meanwhile, as a rapid hemostatic effect is obtained at the initial stage of hemostasis, the impact of blood flow on platelets adsorbed by the nano cuttlebone powder can be reduced in the hemostatic process, the effect of the second nano cuttlebone powder 1014 is promoted, and the hemostatic effect of the hydrogel wound dressing is further improved.
In some embodiments, the first nano cuttlebone powder 1013 accounts for 5% -15% of the mass of the first hydrogel skeleton 1011. The second nano cuttlebone powder 1014 accounts for 2% -10% of the mass of the second hydrogel framework 1012. The nano cuttlebone powder content is too low, and may not provide enough coagulation promoting components, resulting in prolonged hemostasis time. Meanwhile, the internal structure of the hydrogel framework can be changed by adding the nano cuttlebone powder, and the nano cuttlebone powder with proper dosage can be used as a reinforcing phase to improve the strength of the hydrogel framework. The content of the nano cuttlebone powder is too high, which may affect the intrinsic performance of the hydrogel skeleton. For example, when the content of the nano cuttlebone powder is too high, the excessive nano particles limit the movement of the polymer chains, so that the hydrogel skeleton becomes stiff, and the elasticity of the hydrogel skeleton may be reduced.
Alternatively, the first nano cuttlebone powder 1013 may be 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, etc. by mass of the first hydrogel skeleton 1011. It can be appreciated that the mass percentage of the first nano cuttlebone powder 1013 to the first hydrogel skeleton 1011 may be selected within the range of 5% -15%. Alternatively, the second nano-cuttlebone powder 1014 may comprise 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, etc. of the mass percent of the second hydrogel scaffold 1012. It is understood that the mass percentage of the second nano cuttlebone powder 1014 to the second hydrogel skeleton 1012 may be selected within the range of 2% -10%.
In some of these embodiments, the thickness of the first hydrogel scaffold 1011 is greater than the thickness of the second hydrogel scaffold 1012. The thicker first hydrogel skeleton 1011 is capable of holding more of the larger particle size first nano-cuttlebone powder 1013, providing sufficient cuttlebone composition to initiate a rapid hemostatic process upon initial contact with the wound. The thinner second hydrogel framework 1012 can enable the second nano cuttlebone powder 1014 to have a shorter transfer distance, so that the transfer rate of the second nano cuttlebone powder 1014 to the first hydrogel framework 1011 can be improved, the second nano cuttlebone powder 1014 can be more quickly supplemented between the first nano cuttlebone powder 1013, the continuous hemostasis is promoted, and the hemostasis effect of the hydrogel wound dressing is improved.
In some embodiments, the thickness of the first hydrogel skeleton 1011 is 0.3mm to 2mm. The thickness of the second hydrogel skeleton 1012 is 0.2mm to 1.5mm. When the thickness of the first hydrogel skeleton 1011 and the second hydrogel skeleton 1012 is too small, it is difficult to accommodate a sufficient amount of the first nano-cuttlebone powder 1013 and the second nano-cuttlebone powder 1014, thereby limiting the hemostatic effect. Also, when the thickness of the first hydrogel scaffold 1011 and the second hydrogel scaffold 1012 is too small, it is difficult to provide a physical barrier of sufficient strength to the wound, so that the risk of secondary injury of the wound due to friction, collision, etc. increases. Meanwhile, when the thickness of the first hydrogel skeleton 1011 and the second hydrogel skeleton 1012 is too small, the isolation effect on contaminants such as external bacteria and dust is poor, which may cause the external contaminants to easily invade the hydrogel wound dressing, thereby slowing down the wound healing speed. And when the thickness of the first hydrogel skeleton 1011 and the second hydrogel skeleton 1012 is too large, the too thick hydrogel skeleton may cause the hydrogel wound dressing to be not tightly attached to the wound, so that a gap is easily generated, and a space is provided for bacteria breeding. Meanwhile, too thick a hydrogel scaffold may deteriorate the breathability of the wound dressing, so that the wound healing speed is slowed. In addition, when the thickness of the first hydrogel skeleton 1011 and the second hydrogel skeleton 1012 is too large, the dressing may generate a more remarkable foreign body sensation at the wound, resulting in a deteriorated use experience for the user.
Alternatively, the thickness of the first hydrogel skeleton 1011 may be 0.3mm、0.4mm、0.5mm、0.6mm、0.7mm、0.8mm、0.9mm、1mm、1.1mm、1.2mm、1.3mm、1.4mm、1.5mm、1.6mm、1.7mm、1.8mm、1.9mm、2mm or the like. It is understood that the thickness of the first hydrogel backbone 1011 may be selected within the range of 0.3mm to 2mm as appropriate. Alternatively, the thickness of the second hydrogel scaffold 1012 may be 0.2mm, 0.3mm, 0.4mm, 0.5mm, 0.6mm, 0.7mm, 0.8mm, 0.9mm, 1mm, 1.1mm, 1.2mm, 1.3mm, 1.4mm, 1.5mm, etc. It will be appreciated that the thickness of the second hydrogel matrix 1012 may be selected within the range of 0.2mm to 1.5 mm.
For superficial wounds, such as blister breaks, mild abrasions, etc., the thickness of the hydrogel scaffold may be relatively thin. Alternatively, the thickness of the first hydrogel skeleton 1011 may be designed to be 0.5mm to 1mm, and the thickness of the second hydrogel skeleton 1012 may be designed to be 0.3mm to 0.8mm. The thickness can ensure that the nano cuttlebone powder plays a role in stopping bleeding, can not cause excessive compression on wounds, and is beneficial to rapid healing of the wounds.
For deep wounds, such as cuts, punctures, etc., a thicker hydrogel scaffold is required to provide adequate protection and hemostatic function. Alternatively, the thickness of the first hydrogel skeleton 1011 may be designed to be 1mm to 2mm, and the thickness of the second hydrogel skeleton 1012 may be designed to be 0.8mm to 1.5mm. The thicker first hydrogel scaffold 1011 is capable of storing more of the first nano-cuttlebone powder 1013 to cope with the large amount of bleeding that may occur in deep wounds, while the thicker second hydrogel scaffold 1012 ensures that there is enough of the second nano-cuttlebone powder 1014 for subsequent hemostasis.
For short term use wound dressings, such as disposable wound dressings, the hydrogel scaffold thickness may be suitably reduced. Thus, the cost and the material consumption can be reduced while the basic hemostatic and protective functions are ensured. Optionally, for some small-area, shallow wounds, the thickness of the first hydrogel scaffold 1011 may be 0.3mm to 0.8mm and the thickness of the second hydrogel scaffold 1012 may be 0.2mm to 0.6mm in a dressing for short term use.
For long-term use of wound dressings, such as those used for chronic wound care, it is desirable to appropriately increase the thickness of the hydrogel scaffold. This is because the dressing is required to continuously provide hemostatic, protective and wound healing functions during long-term use. Optionally, the thickness of the first hydrogel skeleton 1011 is 1 mm-2 mm, and the thickness of the second hydrogel skeleton 1012 is 0.8 mm-1.5 mm, so as to ensure that the sufficient nano cuttlebone powder and good physical barrier function are provided.
In some embodiments, the first hydrogel backbone 1011 comprises a first hydrophilic polymer material comprising sodium alginate and a first cross-linking agent comprising calcium chloride. The second hydrogel skeleton 1012 contains a second hydrophilic polymer material and a second crosslinking agent, wherein the second hydrophilic polymer material comprises one or more of polyacrylamide and polyvinyl alcohol, and the second crosslinking agent comprises glutaraldehyde. By selecting a suitable hydrophilic polymer material and a crosslinking agent, the first hydrogel skeleton 1011 and the second hydrogel skeleton 1012 having excellent properties can be advantageously obtained.
Sodium alginate belongs to natural polysaccharide substances, has wide sources and good biocompatibility and biodegradability. In the presence of calcium ions, sodium alginate can rapidly form gel, so that the hydrogel wound dressing is convenient to prepare. In addition, sodium alginate has certain antibacterial property, and can reduce the risk of wound infection. Meanwhile, sodium alginate can effectively absorb and retain wound exudates, maintain a moist environment of a wound, and the moderately moist environment can promote cell migration, proliferation and angiogenesis, so that the first hydrogel skeleton 1011 comprises sodium alginate can effectively promote wound healing. The calcium chloride can undergo an ionic crosslinking reaction with the carboxyl in the sodium alginate to form gel, so that a first stable hydrogel skeleton 1011 is formed.
The polyacrylamide has good water absorbability and biocompatibility, and can form a stable hydrogel structure. The amide groups on the molecular chain can form hydrogen bonds with water molecules, so that the water-retaining property of the hydrogel framework is improved. In addition, the polyacrylamide also has certain viscoelasticity, can adapt to the shape change of wounds, and provides good fit. The polyvinyl alcohol is nontoxic and biodegradable, and has good film forming property and mechanical strength. The properties of the hydrogel can be adjusted by blending or crosslinking with polyacrylamide. In addition, the polyvinyl alcohol hydrogel has higher transparency, and is convenient for observing the healing condition of wounds. Thus, the inclusion of polyacrylamide and polyvinyl alcohol in the second hydrogel scaffold 1012 may improve the fit, elasticity, and observability of the hydrogel wound dressing. Glutaraldehyde can undergo a crosslinking reaction with groups such as amino groups in the second hydrophilic polymer material to form a stable three-dimensional network structure, thereby forming a relatively stable second hydrogel framework 1012.
In some embodiments, the first cross-linking agent accounts for 1-5% of the mass of the first hydrogel skeleton 1011, and the second cross-linking agent accounts for 0.1-1% of the mass of the second hydrogel skeleton 1012. The proper amount of the cross-linking agent can reduce the problems of excessive cross-linking caused by excessive cross-linking agent and a large amount of residual cross-linking agent while obtaining a better cross-linking effect.
Alternatively, the first crosslinker may comprise 1%, 1.2%, 1.5%, 1.8%, 2%, 2.2%, 2.5%, 2.8%, 3%, 3.2%, 3.5%, 3.8%, 4%, 4.2%, 4.5%, 4.8%, 5% by mass of the first hydrogel backbone 1011. It is understood that the mass percentage of the first cross-linking agent in the first hydrogel skeleton 1011 may be selected within the range of 1% -5%. Alternatively, the second crosslinker may comprise 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, etc. by mass of the second hydrogel backbone 1012. It will be appreciated that the mass percent of the second cross-linking agent in the second hydrogel backbone 1012 may be selected to be in the range of 0.1% to 1%.
In some of these embodiments, the nano-cuttlebone containing hydrogel wound dressing 100 further includes a waterproof breathable membrane 102. The waterproof and breathable membrane 102 is positioned on the isolation surface, and the material of the waterproof and breathable membrane 102 comprises one or more of polytetrafluoroethylene and polyurethane. In hydrogel wound dressings, it is necessary to prevent the hydrogel scaffold from losing its original properties due to excessive water absorption caused by external moisture ingress. Sufficient oxygen supply may be provided to aid in wound healing. Thus, the waterproof breathable film 102 can provide better waterproof effect and breathability for the wound dressing. When the waterproof and breathable film 102 is selected, the low moisture permeability and continuous polymer structure of the materials in the polytetrafluoroethylene and the polyurethane can prolong the permeation path of water molecules, so that the waterproof and breathable film 102 has good waterproof effect, and the micropore structure of the materials can provide good breathability.
In some of these embodiments, the waterproof breathable film 102 has a thickness of 10 μm to 30 μm. The thickness of the waterproof and breathable film 102 is in this range, which allows both better waterproof and breathable properties. Alternatively, the thickness of the waterproof breathable film 102 may be 10 μm, 12 μm, 15 μm, 18 μm, 20 μm, 22 μm, 25 μm, 28 μm, 30 μm, etc. It will be appreciated that the thickness of the waterproof breathable membrane 102 may be selected to be within the range of 10 μm to 30 μm.
In some embodiments, the hydrogel wound dressing 100 comprising nano-cuttlebone further comprises a protective film 103, the protective film 103 is positioned on the dressing surface, and the material of the protective film 103 comprises one or more of polyethylene and polypropylene. The protective film 103 may prevent contamination of the dressing surface of the hydrogel wound dressing.
In some of these embodiments, the thickness of the protective film 103 is 40 μm to 60 μm. Alternatively, the thickness of the protective film 103 may be 40 μm, 42 μm,45 μm, 48 μm,50 μm, 52 μm, 55 μm, 58 μm,60 μm, or the like. It is understood that the thickness of the protective film 103 may be selected within the range of 40 μm to 60 μm.
Still another embodiment of the present invention provides a method for preparing the hydrogel wound dressing 100 containing nano cuttlebone. The preparation method comprises the following steps:
S101, respectively mixing the first hydrophilic polymer material and the second hydrophilic polymer material with water to respectively obtain a first polymer solution and a second polymer solution.
S102, mixing the first nano cuttlebone powder 1013 with a first polymer solution to obtain a first hydrogel precursor liquid. Mixing the second nano cuttlebone powder 1014 with a second polymer solution to obtain a second hydrogel precursor liquid.
And S103, adding the first hydrogel precursor liquid into a die, and performing cross-linking shaping to obtain a first hydrogel skeleton 1011.
And S104, adding the second hydrogel precursor solution to the first hydrogel skeleton 1011, and performing cross-linking shaping to obtain a second hydrogel skeleton 1012.
Alternatively, the first nano cuttlebone powder 1013 and the second nano cuttlebone powder 1014 may be obtained in respective particle sizes by ball milling.
Optionally, during S103 crosslinking and shaping, a first crosslinking agent is added into the first hydrogel precursor liquid. And S104, adding a second crosslinking agent into the second hydrogel precursor liquid during crosslinking and shaping.
Optionally, a waterproof and breathable membrane 102 is coated on the surface of the second hydrogel backbone 1012 remote from the first hydrogel backbone 1011.
Optionally, a protective film 103 is coated on the surface of the first hydrogel backbone 1011 remote from the second hydrogel backbone 1012.
The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, and alternatives falling within the spirit and principles of the invention.
Those skilled in the art will appreciate that the conception, upon which this disclosure is based, may readily be utilized as a basis for the designing of other structures for carrying out the several purposes of the present invention.