Background
Allergic rhinitis, also known as allergic rhinitis, is a common chronic nasal disease characterized by an excessive immune response to specific allergens, which usually involve IgE antibodies in the immune system, and common allergens include pollen, dust mites, pet dander, mould spores, etc., which produce a series of symptoms when entering the nasal cavity. The main symptoms related to allergic rhinitis include frequent and strong sneezing, runny nose, nasal obstruction, nasal itching, redness and itching of eyes, itching of throat and the like.
Allergic rhinitis is a common and highly developed disease and is treated relatively well-established, and generally involves identifying and minimizing exposure to allergens in life, and fundamentally preventing and reducing the occurrence of allergic reactions. The most common treatments are drug therapies, for example, non-sedating antihistamines such as over-the-counter lolidine, cetirizine, etc. can relieve sneeze, runny nose and itching, etc. symptoms, and nasal corticosteroid sprays such as fluticasone, budesonide, etc. can be used to effectively reduce the related inflammation of the nasal mucosa by external application of the above drugs. The traditional Chinese medicine preparation can be taken for treatment, and the traditional Chinese medicine preparation mainly aims at treatment according to the traditional Chinese medicine theory, and common traditional Chinese medicines comprise magnolia flower, peppermint, astragalus and bighead atractylodes rhizome and the like. In addition, lifestyle changes, such as keeping indoor air clean, using air cleaners, periodically changing filter screens, keeping indoor environment sanitary dry, etc., are common ways of daily precautions.
However, the existing treatment methods have problems to various degrees, for example, in western medicine, medicines including hormone, decongestant, antihistamine, antiallergic, surgery and the like have side effects. In the treatment of traditional Chinese medicines, the liquid medicine decocted by the traditional Chinese medicines is too bitter, so that people are difficult to adhere to, especially the children are difficult to swallow, and the nasal mucosa injury is particularly serious when the conditioning products for rhinitis are externally smeared on the market at present, so that the traditional Chinese medicines are not preferable.
For example, the prior art with publication number CN115708859A discloses a pharmaceutical composition for treating allergic rhinitis, which comprises astragalus, bighead atractylodes rhizome, radix sileris, magnolia flower, notopterygium root and other components as raw materials, and Chinese medicinal components such as ephedra, stir-fried radix sileris, stiff silkworm, fructus xanthii and the like as well as the pharmaceutical composition for treating allergic rhinitis in the patent application with publication number CN 114949082A. Patent application publication No. CN104855984A, although using a number of medicinal and edible raw materials, the raw materials are up to hundreds. In summary, the existing researches do not use medicinal and edible raw materials to obtain a medicinal product aiming at allergic rhinitis through reasonable compatibility.
The rhinitis crowd in China increases year by year, the rhinitis crowd shows a trend of miniaturization, children patients gradually become main bodies of morbidity, intervention treatment needs to be performed as early as possible, and the Western medicine and the traditional Chinese medicine treatment method have a plurality of adverse effects and obviously do not meet the medication requirements of the children crowd. Based on the problems, the invention is put forward under the guidance of the traditional Chinese medicine foundation for the purpose of physical health and medication safety of children and along with the increasing importance of the national use of homologous components of medicine and food, so as to solve a plurality of problems in the prior art.
Disclosure of Invention
Aiming at the problems, the invention is based on the characteristics of the pathogenesis of the allergic rhinitis of children through researching the treatment mechanism and the treatment rule of the allergic rhinitis, and the reasonable compatibility of medicinal and edible medicinal materials is adopted to highlight the effects of reducing lung diarrhea, clearing heat and detoxicating, improving spleen deficiency and enhancing immunity of the medicament, and the various raw materials are matched in a synergistic way to jointly improve the related symptoms of nasal obstruction, nasal itching, eye itching, nasal discharge, hyposmia and the like of the allergic rhinitis.
In the early stage of the treatment process of allergic rhinitis, wind dispelling and exterior syndrome relieving are needed to dispel wind evil, relieve nasal itching and sneeze symptoms, lung heat is needed to clear for lung heat type allergic rhinitis, spleen and qi deficiency type allergic rhinitis is mainly treated by strengthening spleen and stomach functions and improving organism tolerance, and yin deficiency type allergic rhinitis is mainly treated by nourishing lung yin, relieving nasal dryness, dry throat and the like. Children should pay more attention to the improvement of immunity and the improvement of spleen and stomach functions in the treatment process due to low autoimmune power and spleen deficiency.
When the raw materials are compatible, five starter in a green nursing mode is initiated aiming at various nose chronic diseases, including nourishing, dispelling, supporting, fumigating and training. Wherein, a, acupoint selection along the channel is maintenance, b, meridian warming and vein relaxing is evil eliminating, c, internal regulation and external maintenance are carried out, body resistance is strengthened, d, dehumidification and cold dispelling are carried out, fumigation is used, and e, allergy resistance is assisted and outdoor training is carried out. Experiments prove that the rhinitis customer feedback satisfaction is very high.
On the one hand, the invention provides a medicine and food homologous composition for allergic rhinitis, which is characterized by comprising, by weight, 25-40 parts of cordate houttuynia, 15-40 parts of radix angelicae, 15-40 parts of honeysuckle, 20-35 parts of coix seed, 8-30 parts of rhizoma polygonati, 10-30 parts of astragalus mongholicus, 4-20 parts of codonopsis pilosula, 3-18 parts of fingered citron, 6-20 parts of dark plum, 6-20 parts of platycodon grandiflorum, 3-25 parts of mint, 3-20 parts of liquorice and 10-40 parts of honey.
The preferable scheme comprises the raw materials of, by weight, 28-36 parts of cordate houttuynia, 20-30 parts of radix angelicae, 20-30 parts of honeysuckle, 23-32 parts of coix seed, 10-25 parts of rhizoma polygonati, 13-26 parts of astragalus membranaceus, 8-16 parts of codonopsis pilosula, 5-15 parts of fingered citron, 8-18 parts of dark plum, 8-16 parts of platycodon grandiflorum, 5-20 parts of mint, 6-16 parts of liquorice and 20-35 parts of honey.
The preferable scheme comprises the following raw materials, by weight, 32 parts of cordate houttuynia, 25 parts of radix angelicae, 25 parts of honeysuckle, 27 parts of coix seed, 18 parts of rhizoma polygonati, 20 parts of astragalus membranaceus, 10 parts of codonopsis pilosula, 12 parts of fingered citron, 14 parts of dark plum, 15 parts of platycodon grandiflorum, 13 parts of mint, 11 parts of liquorice and 28 parts of honey.
The cordate houttuynia herb in the invention has the effects of clearing away heat and toxic materials, eliminating carbuncle and swelling, playing a main role in clearing away heat and toxic materials, and can enter the lung to reduce diarrhea, treat the discomfort of the lung and the airway caused by allergic rhinitis, remove redundant gas, reduce the discomfort of patients and play a main role.
Radix Angelicae Dahuricae is a common drug for treating allergic rhinitis, and has effects in clearing away heat and qi, relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, dredging nasal orifices, relieving swelling, inducing resuscitation, treating acute and chronic rhinitis, and nasal obstruction and nasal discharge.
Honeysuckle flower has sweet and cold nature, can disperse wind heat, cool blood and stop bleeding, has the effects of clearing heat and detoxicating, diminishing inflammation and removing swelling, and is mainly used for treating various infectious diseases such as exogenous wind heat or warm disease fever, heatstroke, toxic heat blood dysentery, carbuncle and furuncle, pharyngitis and the like.
The coix seed enters spleen, stomach and lung meridians, is favorable for promoting diuresis and removing dampness, has the effects of strengthening spleen and stopping diarrhea, removing arthralgia, expelling pus, detoxifying and resolving masses, and has the effect of enhancing the immunity of children organisms.
Rhizoma Polygonati is effective in invigorating qi, nourishing yin, invigorating spleen, regulating stomach function, moistening lung, promoting salivation, moistening dryness, relieving cough, invigorating kidney, and nourishing yin.
Astragalus root, radix astragali enters the lung and spleen and has the effects of tonifying qi and yang, tonifying defensive qi and consolidating superficial resistance, inducing diuresis and relieving edema, promoting the production of body fluid and nourishing blood.
Codonopsis pilosula has sweet taste and mild nature, and has the effects of invigorating spleen, tonifying lung, nourishing blood and promoting fluid production.
The fingered citron enters the liver, spleen and stomach to achieve the effects of regulating qi, resolving phlegm, relieving vomiting, relieving distension, soothing the liver, strengthening the spleen, harmonizing the stomach and the like.
The dark plum fruit enters the large intestine of the lung, liver and spleen, has the effects of promoting the production of body fluid, astringing the lung, treating chronic cough due to lung deficiency, cough due to lung dryness, nasal discomfort and the like, and has better improving effect on allergic rhinitis runny nose caused by nasal obstruction runny nose and weak lung qi deficiency.
Radix Platycodi has effects of dispersing lung qi, eliminating phlegm, relieving sore throat, and removing toxic substances, and can be used for treating cough with excessive phlegm, chest distress, pharyngalgia, hoarseness, pulmonary abscess, and suppuration, and pyogenic infection.
The peppermint has the effects of dispelling wind and heat, detoxifying and promoting eruption, and clearing head and eyes, and can effectively relieve symptoms when being applied to patients with allergic rhinitis.
The liquorice enters the heart and lung and spleen and has the effects of tonifying middle-jiao and Qi, moistening lung for arresting cough, clearing heat and detoxicating, relieving urgency and stopping pain and the like.
On the other hand, the invention also provides a preparation of the medicinal and edible composition for treating allergic rhinitis, which is prepared by taking the composition as an active ingredient.
Preferably, the preparation is in the form of tablets, granules, capsules or oral liquid.
In a third aspect of the present invention, there is provided a method of preparing a formulation of a pharmaceutical and dietetic composition for allergic rhinitis, comprising the steps of:
1) Weighing the raw materials according to parts by weight, and coarsely crushing other medicinal and edible traditional Chinese medicine components except honey to obtain a pretreated raw material;
2) Adding 5-8 times of water into pretreated houttuynia cordata, honeysuckle, coix seed, rhizoma polygonati, astragalus, codonopsis pilosula, dark plum and liquorice, leaching for 20 minutes at 50-70 ℃, filtering, separating filtrate, adding 4-6 times of water into filter residues, leaching for 20 minutes at 50-70 ℃ continuously, filtering to obtain filtrate, and combining the two filtrates to obtain pretreated matter A;
Adding water with the dosage of 4-8 times of the raw materials into the pretreated radix angelicae, fingered citron, platycodon grandiflorum and peppermint, extracting by adopting a steam distillation method to obtain volatile oil, condensing by adopting a multi-stage condensing system, collecting the volatile oil B, continuously collecting distilled aqueous solution, and filtering to obtain a treated substance C;
3) Concentrating the pretreated material A and the treated material C under reduced pressure, mixing with the volatile oil B, concentrating, and mixing with Mel under stirring to obtain active extract;
4) The active extract obtained in the step 3) is used as a raw material to prepare a preparation of the medicine-food homologous composition aiming at allergic rhinitis.
Preferably, in the step 3), the mixture is further concentrated to a relative density of 1.2-1.3.
Further preferably, the stirring and mixing in the step 3) is carried out at a rotation speed of 500-800rpm.
Compared with the prior art, the technical scheme provided by the invention at least comprises the following beneficial effects:
(1) The raw material combination of the invention adopts natural plants, has no toxic or side effect and high safety, belongs to the medicinal and edible homologous medicinal materials issued by Wei Jian Committee, completely does not use medicinal components, avoids bad taste and toxic or side effect caused by the use of the traditional Chinese medicine raw materials, and is more suitable for patients suffering from allergic rhinitis, especially children rhinitis.
(2) The combination of raw materials is selected according to the symptoms of specific allergic rhinitis in the raw material compatibility. In the recipe, cordate houttuynia enters lung and purges, heat and toxic materials are cleared away, the recipe is pungent and has the effects of resolving hard mass, eliminating carbuncles and expelling pus to relieve nasal orifices, dahurian angelica root enters yangming and clear qi, relieving exterior syndrome and cold, freeing nasal orifices, clearing heat and detoxicating, relieving swelling and opening orifices, honeysuckle flower enters lung and stomach, the effects of diminishing inflammation and clearing heat are combined, coix seed is used as a monarch drug for strengthening spleen and promoting diuresis and enhancing immunity, the ministerial drugs are rhizoma polygonati for nourishing kidney and tonifying liver, astragalus root for tonifying qi and yang, strengthening exterior and arresting sweating, sweet temperature, tonifying qi, dangshen for tonifying qi and strengthening exterior, and reducing anaphylactic reaction, fingered citron for soothing liver and relieving depression, regulating spleen and stomach, the drugs have the effects of strengthening toxin and expelling pus, dark plum acid and astringing yin to harmonize nutrient, platycodon root for carrying medicine for ascending lung and expelling pus, peppermint for relieving symptoms, and licorice root is used as a drug property. The honey contains various enzymes and minerals, is beneficial to enhancing immunity, can improve the taste of the medicine, and is convenient to take. The medicines are used together to collect and disperse wind, strengthen superficies, disperse lung qi, dredge orifices, clear away heat and toxic materials, improve spleen and stomach weakness and strengthen immunity, and have the beneficial effects of improving symptoms of allergic rhinitis.
(3) The raw materials are compatible, and the traditional Chinese medicine theory aims at regulating the body immune system from the aspects of large view and whole view, so that the self-healing capacity of the body is enhanced, and the prevention of the disease is achieved. Aiming at the characteristics of allergic rhinitis of children, the traditional Chinese medicine lung-purging qi-reducing treatment method is used, firstly, lung and airway discomfort caused by allergic rhinitis is treated, redundant gas is removed, discomfort of patients is relieved, and therefore the breathing time and strength are prolonged, the therapy can also enhance the body resistance, in the formula, coix seeds are used as monarch drugs and cordate houttuynia are used together to enhance the body resistance, and the honey has the effect of enhancing the resistance while improving the taste, and has outstanding effects of reducing lung-purging, clearing heat and detoxicating, improving spleen deficiency and enhancing immunity by focusing on injection of children patients with low immunity.
(4) When the pharmaceutical preparation is prepared, the chemical property, the thermal stability, the polarity and the cost benefit of a target compound are fully considered, the extraction modes of different raw materials are adjusted according to the difference of raw materials, such as hot water full extraction is carried out on houttuynia cordata, coix seed, honeysuckle, rhizoma polygonati, astragalus mongholicus, codonopsis pilosula, dark plum and liquorice, the volatile oil is extracted from the raw materials containing volatile oil active ingredients, such as angelica dahurica, fingered citron, platycodon grandiflorum and peppermint by adopting a steam distillation method, then the distilled water is further concentrated and fully utilized for water-soluble ingredients, and the water-soluble ingredients are fully mixed during preparation, so that the functional ingredients of the raw materials are fully exerted.
(5) The medicinal and edible composition has reasonable compatibility of raw materials, exerts the treatment effects on allergic rhinitis patients, especially children patients, from the effects of lung entering, diarrhea, heat clearing, detoxifying, spleen deficiency improving, immunity enhancing and the like, and the raw materials are matched in a synergistic manner, and the addition and the subtraction of the raw material components are not only focused on rhinitis, but also aim to balance the body immune system to balance the rhinitis so as to achieve self-healing. The invention integrally embodies the dialectical treatment principle of traditional Chinese medicine treatment, and experiments prove that the composition has definite curative effect, better clinical behavior index, blood lgE index and comprehensive index.
Detailed Description
Other advantages and effects of the present invention will become apparent to those skilled in the art from the following disclosure, which describes the embodiments of the present invention with reference to specific examples. It will be apparent that the described embodiments are only some, but not all, embodiments of the invention.
The invention may be practiced or carried out in other embodiments that depart from the specific details, and the details of the present description may be modified or varied from the spirit and scope of the present invention. It should be noted that the following embodiments and features in the embodiments may be combined with each other without conflict. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Example 1
A medicinal and edible granule preparation for treating allergic rhinitis comprises, by weight, 32 parts of cordate houttuynia, 25 parts of radix angelicae, 25 parts of honeysuckle, 27 parts of coix seed, 18 parts of rhizoma polygonati, 20 parts of astragalus, 10 parts of radix codonopsis, 12 parts of fingered citron, 14 parts of dark plum, 15 parts of platycodon grandiflorum, 13 parts of mint, 11 parts of liquorice and 28 parts of honey;
the preparation method of the granule comprises the following steps:
1) Weighing the raw materials according to parts by weight, and coarsely crushing other medicinal and edible traditional Chinese medicine components except honey to obtain a pretreated raw material;
2) Adding 6 times of water of the pretreated houttuynia cordata, honeysuckle, coix seed, rhizoma polygonati, astragalus membranaceus, codonopsis pilosula, dark plum and liquorice into the raw materials by weight, leaching for 20 minutes at 60 ℃, filtering, separating filtrate, adding 5 times of water of the raw materials by weight into filter residues again, leaching for 20 minutes at 60 ℃ continuously, filtering to obtain filtrate, and combining the two filtrates to obtain a pretreated matter A;
adding water with the dosage of 6 times of that of the raw materials into the pretreated dahurian angelica root, fingered citron, platycodon root and peppermint, extracting by adopting a steam distillation method to obtain volatile oil, condensing by adopting a multi-stage condensing system, collecting the volatile oil B, continuously collecting distilled aqueous solution, and filtering to obtain a treated substance C;
3) Concentrating the pretreated material A and the treated material C under reduced pressure, mixing with the volatile oil B, concentrating to a relative density of 1.25, and mixing with Mel under stirring to obtain active extract;
4) The active extract obtained in the step 3) is used as a raw material, and the medicinal and edible granule preparation aiming at allergic rhinitis is prepared by adopting a granule processing technology.
Example 2
A medicinal and edible granule preparation for treating allergic rhinitis comprises, by weight, 25 parts of herba Houttuyniae, 15 parts of radix Angelicae Dahuricae, 15 parts of flos Lonicerae, 20 parts of Coicis semen, 8 parts of rhizoma Polygonati, 10 parts of radix astragali, 4 parts of radix Codonopsis, 3 parts of fructus Citri Sarcodactylis, 6 parts of mume fructus, 6 parts of radix Platycodi, 3 parts of herba Menthae, 3 parts of Glycyrrhrizae radix, and 10 parts of Mel;
the preparation method of the granule comprises the following steps:
1) Weighing the raw materials according to parts by weight, and coarsely crushing other medicinal and edible traditional Chinese medicine components except honey to obtain a pretreated raw material;
2) Adding 6 times of water of the pretreated houttuynia cordata, honeysuckle, coix seed, rhizoma polygonati, astragalus membranaceus, codonopsis pilosula, dark plum and liquorice into the raw materials by weight, leaching for 20 minutes at 60 ℃, filtering, separating filtrate, adding 5 times of water of the raw materials by weight into filter residues again, leaching for 20 minutes at 60 ℃ continuously, filtering to obtain filtrate, and combining the two filtrates to obtain a pretreated matter A;
adding water with the dosage of 6 times of that of the raw materials into the pretreated dahurian angelica root, fingered citron, platycodon root and peppermint, extracting by adopting a steam distillation method to obtain volatile oil, condensing by adopting a multi-stage condensing system, collecting the volatile oil B, continuously collecting distilled aqueous solution, and filtering to obtain a treated substance C;
3) Concentrating the pretreated material A and the treated material C under reduced pressure, mixing with the volatile oil B, concentrating to a relative density of 1.25, and mixing with Mel under stirring to obtain active extract;
4) The active extract obtained in the step 3) is used as a raw material, and the medicinal and edible granule preparation aiming at allergic rhinitis is prepared by adopting a granule processing technology.
Comparative example 1
The raw materials are not used with houttuynia cordata, the amount of houttuynia cordata is increased to be equal to that of main angelica dahurica and coix seed, namely 41 parts of angelica dahurica and 43 parts of coix seed, and the composition and preparation method of the other raw materials are the same as those of the example 1, so that the granular preparation is prepared.
Comparative example 2
The raw materials are not used with coix seeds, the quantity of coix seeds is increased to be equal to that of main cordate houttuynia and angelica dahurica, namely 45.5 parts of cordate houttuynia and 38.5 parts of angelica dahurica, and the composition and the preparation method of the rest raw materials are the same as those of the example 1, so that the granular preparation is prepared.
Experimental example
1. Animal experiment research
(1) Animal modeling, namely constructing a mouse model of allergic rhinitis by using an antigen induction method, specifically comprising the steps of selecting 100 female mice with the age of 5 weeks for modeling, suspending the mice in 200 mu l of PBS solution by using 25 mu g of OVA as an antigen and 1mg of aluminum hydroxide as an adjuvant during the gastric lavage period, immunizing the mice, and generally, requiring multiple immunization to generate specific IgE antibodies until the allergic rhinitis of the mice is induced, and judging that the modeling is successful.
(2) The experimental animals were treated in five groups of animals, namely, a positive control group (loratadine treatment), a blank control group, an example group (example 1) and a comparative example group (comparative examples 1 and 2). The obtained granules are prepared into 8% uniform aqueous solution according to the requirement in the example group and the comparative example group, each treatment group adopts a gastric lavage mode to treat experimental mice, wherein the positive control group is used for treating the mice at a dosage of 3mg/kg, 0.6ml of the aqueous solution of the example 1 and the aqueous solution of the comparative examples 1 and 2 are filled into each mouse in the example group and the comparative example group, the normal saline with the same amount is filled into each mouse in the blank control group, the treatment groups are treated for 3 times per day, the treatment groups are continuously used for 10 days, and then each index is measured.
(3) Experimental method
In the measurement process, firstly, the behaviors of mice in different treatment groups are evaluated according to the behavioral scoring standard of the allergic rhinitis mice, then, animals are sacrificed, and blood is collected to evaluate the blood immunology related index lgE for measurement.
Wherein the behavioral evaluation criteria of allergic rhinitis mice are shown in Table 1.
TABLE 1 evaluation criteria for behavioural in allergic rhinitis mice
The method for detecting the IgE content in the blood of the mice adopts a universal ELISA kit to detect the IgE content in the blood of each treatment group.
(4) Experimental determination results
Table 2 comparison of the variability of the behavior and the blood IgE levels of mice with allergic rhinitis in different treatment groups
From table 2, it can be seen that the different treatment groups have a great influence on the behavior of allergic rhinitis mice and the IgE content of blood, and the overall treatment effect is similar to that of the positive control group (loratadine) by adopting the sample treatment of the example 1 group of the present invention during the treatment period, which indicates that the composition of the present invention has an excellent effect in treating allergic rhinitis. The treatment conditions of the embodiment 1 of the invention have obvious differences between the behavioral performance and the blood IgE content of the mice and the blank control group, and compared with the comparative examples 1 and 2, the effect is obviously better than that of the comparative examples 1 and 2, the behavioral score is better, the blood IgE content is also better, and the effect on treating allergic rhinitis is poor after the active ingredients of houttuynia cordata and coix seed are respectively discarded. By combining the experimental results, the conclusion can be drawn that the pharmaceutical composition has a good treatment effect on the allergic rhinitis under the condition of the embodiment of the invention, and the treatment effect is affected by the adjustment and change of raw materials, which is similar to that of a positive control group.
2. Clinical application research
(1) Study subjects, namely, allergic rhinitis patients with the age groups distributed in 8-16 years old are selected for study, 80 patients are divided into men and women, and clinical application study is carried out for 20 days, so that the treatment effects of each group are recorded.
(2) The experiment is divided into a positive control group, an example 1 group, a comparative example 1 group and a comparative example 2 group, and the positive control group is taken according to the specified dosage, wherein the positive control group takes loratadine one tablet per day, and the dosage of the example 1 group, the comparative example 1 group and the comparative example 2 group is 3-9 g each time according to the crude drug dosage, and 3 times per day.
(3) The treatment effect was evaluated on the following criteria:
The obvious effect standard is that symptoms such as runny nose, dizziness, nose itching, sneeze and the like are obviously relieved and basically disappear;
The effective standard is that symptoms such as runny nose, dizziness, nose itching, sneeze and the like still exist, and the symptoms are relieved;
the criteria for inefficiency are that the symptoms are the same or prone to exacerbation as compared to pre-treatment.
(4) Results of clinical experiments
The results of the clinical experiments on the patients are shown in table 3.
TABLE 3 comparison of clinical trial results for different treatment groups
From the clinical experimental results in table 3, it can be determined that the total clinical effective rate of the product obtained under the conditions of the embodiment of the invention reaches 90%, which is close to the positive control group of loratadine, and compared with the comparative examples 1 and 2, the product shows better total clinical effective rate under the conditions of the embodiment of the invention, the above results can indicate that the compatibility of raw materials has significant influence on the final treatment effect, the addition of houttuynia cordata and coix seed is indispensable for the compatibility of the whole prescription, and the overall curative effect is definite and excellent.
The foregoing is merely illustrative of the present invention, and the present invention is not limited thereto, and any changes or substitutions easily contemplated by those skilled in the art within the scope of the present invention should be included in the present invention.