Disclosure of Invention
Based on this, an interventional catheter is provided that applies a force directly on the distal end of the guidewire, adjusting the position so that the guidewire more easily passes over an obstruction in the vessel.
An interventional catheter, comprising:
a tube having opposite distal and proximal ends;
The working bag is positioned at the distal end of the pipe body, and a liquid cavity capable of filling or discharging liquid is formed in the working bag;
the excitation assembly adopts a laser fiber or an electrode pair, and the far end of the laser fiber or the electrode pair is positioned in the liquid cavity and has a laser state acted on liquid under the action of a driving signal.
The following provides several alternatives, but not as additional limitations to the above-described overall scheme, and only further additions or preferences, each of which may be individually combined for the above-described overall scheme, or may be combined among multiple alternatives, without technical or logical contradictions.
Optionally, the liquid chamber is generally annular and is disposed about the outer circumference of the tube, the liquid chamber extending axially to a distal-most location of the tube.
Optionally, the excitation component adopts an electrode pair, is arranged at the distal end part of the tube body and is positioned in the liquid cavity, the electrode pair comprises a positive electrode and a negative electrode which are matched with each other, and the positive electrode and the negative electrode are arranged at intervals along the radial direction of the interventional catheter and have a discharge state acting on liquid under a first driving signal.
Optionally, the electrode pairs are 2-4 pairs, the electrode pairs are arranged at intervals along the circumferential direction of the tube body, and the thickness of each electrode is 0.02-0.1 mm.
Optionally, the voltage of the first driving signal is 1000-5000V, the driving frequency is 1-5 Hz, and each driving time is 0.1-0.5 microseconds.
Optionally, the excitation component adopts a laser fiber, the proximal end is a signal input end, and the distal end extends into the liquid cavity and has an excitation state acting on liquid under a second driving signal.
Optionally, the plurality of laser fibers independently receive the second driving signal, all the laser fibers alternately enter the excited state, the interval time between the laser fibers alternately is 0.5 s-1 s, and the time of each laser fiber in the excited state is 0.2-3 s.
The application also provides an interventional assembly comprising:
The interventional catheter;
The guide wire movably penetrates through the interventional catheter, the distal end of the guide wire is a working part extending out of the interventional catheter, and the working part correspondingly moves in an electrode pair discharging state or an excitation state of the laser fiber.
The application also provides an interventional device comprising:
the intervention component;
And a driver for delivering a drive signal to the interventional component.
The application also provides a thrombus taking system, which comprises:
the intervention component;
A driver that delivers a drive signal to the interventional component;
a thrombolysis assembly comprising a microcatheter and a thrombolysis stent delivered and retrieved through the microcatheter.
The application provides an interventional catheter, an interventional assembly, an interventional device and a bolt taking system using the interventional catheter, wherein the interventional catheter directly applies acting force to the distal end of a guide wire, and the guide wire passes through an aperture in an obstacle more easily.
Detailed Description
The following description of the embodiments of the present application will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present application, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the application without making any inventive effort, are intended to be within the scope of the application.
For a better description and illustration of embodiments of the application, reference should be made to one or more of the accompanying drawings, but the additional details or examples used to describe the drawings should not be construed as limiting the scope of any of the inventive, presently described embodiments or preferred modes of carrying out the application.
It will be understood that when an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. When an element is referred to as being "disposed on" another element, it can be directly on the other element or intervening elements may also be present.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used herein in the description of the application is for the purpose of describing particular embodiments only and is not intended to be limiting of the application.
Referring to fig. 1, 2a, 2b, an interventional catheter 100, comprising:
A tube 110 having opposite distal and proximal ends;
a working bladder 120 located at the distal end of the tube body 110, the working bladder 120 having a fluid chamber 140 therein capable of filling or draining fluid;
The electrode pair 130 is disposed at a distal end portion of the tube body 110 and is disposed in the liquid chamber 140, the electrode pair 130 includes a positive electrode 131 and a negative electrode 132 which are matched with each other, and the positive electrode 131 and the negative electrode 132 are arranged at intervals along a radial direction of the interventional catheter 100 and have a discharge state acting on the liquid under a first driving signal.
In the application, the electrode pair 130 is positioned in the liquid cavity 140 at the far end of the tube body 110, the electrode pair 130 discharges and acts on liquid under the first driving signal, the liquid is agitated under the action of the discharging signal, the far end of the tube body 110 is agitated and driven by the agitation, and the agitation is further transmitted to the guide wire 200 in the tube body 110, so that the guide wire 200 is oscillated. When the guidewire 200 encounters an obstruction (e.g., a thrombus) on the inner wall of a vessel, it is very difficult to adjust the position of the guidewire 200 through the obstruction by applying a force to the proximal end, and the guidewire 200 is more flexible through the obstruction by providing rapid jitter to the guidewire 200, allowing it to be quickly repositioned when it encounters the obstruction, and more easily passing through the aperture in the obstruction.
Referring to fig. 1 and 2a, the present application further provides an interventional assembly comprising:
The interventional catheter 100 of the present application;
The guide wire 200 is movably inserted into the interventional catheter 100, the distal end of the guide wire 200 is provided with a working portion 210 extending out of the interventional catheter 100, and the working portion 210 moves correspondingly in the discharge state of the electrode pair 130.
The guide wire 200 is a CTO guide wire, and is inserted into the interventional catheter 100, the distal end of the guide wire 200 is a working portion 210, when the electrode pair 130 discharges under the first driving signal and acts on the liquid, the liquid is agitated under the action of the discharging signal, the agitating belt rapidly shakes the distal end of the tube 110, and when the distal end of the tube 110 shakes, the action portion of the guide wire 200 is driven to shake, so that the working portion 210 can rapidly adjust the position, and the position can pass through the pores in the obstacle.
Referring to fig. 2b and 2c, the pipe wall of the pipe body 110 has opposite inner and outer sides, and both the positive electrode 131 and the negative electrode 132 are positioned correspondingly in the circumferential direction of the pipe body 110, one side being on the inner side and the other side being on the outer side.
The positive electrode 131 and the negative electrode 132 of the electrode pair 130 are respectively positioned correspondingly in the circumferential direction of the tube body 110, and when the positive electrode 131 is positioned at the inner side, the negative electrode 132 is positioned at the outer side; when the positive electrode 131 is on the outside, the negative electrode 132 is on the inside.
Since the positive electrode 131 and the negative electrode 132 are located on the wall of the tube body 110 and are located at corresponding positions in the circumferential direction of the tube body 110, when the electrode pair 130 discharges under the first driving signal, the movement of the tube body 110 in the cross section thereof is easier to bring, rather than the movement along the axial direction thereof, and of course, when the tube body 110 shakes, the movement component in each direction appears more, but with the arrangement of the electrode pair 130 of the present application, the movement component in the cross section can be expected to be larger.
Referring to fig. 2a, an electrode pair 130 is located at a distal end face 111 of the tube 110, and each electrode receives a first driving signal through a corresponding wire. The wires are omitted in the figure, the electrode pair 130 is located at the distal end face 111 of the tube body 110, and when the electrode pair 130 moves, the distal end of the tube body 110 is directly driven to shake.
Referring to fig. 2a, interventional catheter 100 is further provided with a supply tube 141 connected to liquid lumen 140 and extending further proximally along tube body 110. The liquid supply tube 141 is used to inject liquid into the liquid chamber 140 and provide an object to be acted upon by the electrode pair 130 when discharging.
Referring to fig. 2d, 2e, 2f and 2g, the liquid supply tube 141 is independently configured or provided through a cavity in the tube wall, and the extension portion of the liquid supply tube 141 is selected from at least one of the tube wall interlayer (see fig. 2f and 2 g), the tube wall inner side (see fig. 2 d) and the tube wall outer side (see fig. 2 e). Referring to fig. 2f and 2g, the number of the liquid supply pipes 141 may be plural, for example, two liquid supply pipes 141 are distributed in the interlayer of the pipe wall as shown in fig. 2f, or three liquid supply pipes 141 are distributed in the interlayer of the pipe wall as shown in fig. 2 g.
Referring to fig. 2a, the liquid chamber 140 is generally annular and disposed around the outer circumference of the tube body 110. In fig. 2a, wavy lines are used to illustrate the liquid poured into the liquid chamber 140.
The conducting wire extends along the pipe wall, and the extending part is at least one selected from the interlayer of the pipe wall, the inner side of the pipe wall and the outer side of the pipe wall. A pipe wall interlayer see inside and outside of the tube wall the liquid supply tube 141 is shown in position.
The electrode pairs 130 are 2-4 pairs, and the electrode pairs 130 are arranged at intervals along the circumferential direction of the tube body 110. Referring to fig. 2b, the electrode pairs 130 are two pairs, and referring to fig. 2c, the electrode pairs 130 are four pairs. The electrode pairs 130 are uniformly spaced apart from each other in the circumferential direction of the tube body 110.
In order to solve the problem that the liquid in the working bladder 120 is acted on by the electrode pairs 130 in the discharge state, bubbles are generated on the surface of the discharge electrode pairs 130, so that the agitating effect of the liquid is affected when the next electrode pair 130 is discharged, a plurality of electrode pairs 130 can be provided, and when one electrode pair 130 is discharged, the bubbles generated on the surface can be eliminated by the discharging action of the other electrode pairs 130 on the liquid, for example, when two electrode pairs 130 are respectively A and B, the bubbles are adhered on the surface when A is in the discharge state, and when A is in the non-discharge state and B is in the discharge state, the bubbles on the surface of A can be eliminated when B is discharged on the liquid.
Referring to fig. 2b and 2c, the electrodes on the same side of the tube wall have the same polarity in all the electrode pairs 130. The same side of the tube wall refers to being at the inner side of the tube wall or at the outer side of the tube wall, as shown in fig. 2b, the positive electrodes 131 are all at the inner side of the tube wall, the negative electrodes 132 are all at the outer side of the tube wall, or as shown in fig. 2c, the positive electrodes 131 are all at the outer side of the tube wall, and the negative electrodes 132 are all at the inner side of the tube wall.
Referring to fig. 2a, electrode pairs 130 are disposed at least two positions in the axial direction of the tube body 110, and the distance between adjacent electrode pairs 130 (i.e., L1 in fig. 2 a) is 0.4 to 0.5mm. The distribution of electrode pairs 130 at each axial position is shown with reference to fig. 2b or fig. 2 c. Referring to fig. 2b, the thickness of each electrode (i.e., d in fig. 2 b) is 0.02 to 0.1mm. The thickness of each electrode refers to the dimension in the radial direction of the tube body 110, and is limited by the wall thickness of the tube body 110, and the thickness of the electrode also needs to be thin.
The voltage of the first driving signal is 1000-5000V, the driving frequency is 1-5 Hz, and the driving time length is 0.1-0.5 microsecond each time.
Optionally, the material of the tube body 110 is a polymer material such as nylon, PEBAX, PI (polyimide), or a composite tube containing a woven mesh of stainless steel, nickel titanium, fiber, or the like.
Referring to fig. 1, interventional catheter 100 further includes a handle 170 having a guidewire 200 channel 171, a fluid channel 173 for injecting a liquid into working balloon 120, and a channel 172 for receiving a guidewire.
Referring to fig. 3a, an interventional catheter 100, comprising:
A tube 110 having opposite distal and proximal ends;
a working bladder 120 located at the distal end of the tube body 110, the working bladder 120 having a fluid chamber 140 therein capable of filling or draining fluid;
The laser fiber 150 has a proximal end that is a signal input end, and a distal end that extends into the liquid chamber 140 and has an excited state that acts on the liquid under a second driving signal.
In the application, the distal end of the laser fiber 150 extends into the liquid cavity 140, the laser fiber 150 emits laser to act on liquid under the action of the second driving signal, the liquid is agitated under the action of the laser signal, the far end of the tube 110 is oscillated by the agitation belt, and the oscillation is further transmitted to the guide wire 200 in the tube 110, so that the guide wire 200 is oscillated. When the guidewire 200 encounters an obstruction (e.g., a thrombus) on the inner wall of a vessel, it is very difficult to adjust the position of the guidewire 200 through the obstruction by applying a force to the proximal end, and the guidewire 200 is more flexible through the obstruction by providing rapid jitter to the guidewire 200, allowing it to be quickly repositioned when it encounters the obstruction, and more easily passing through the aperture in the obstruction.
Referring to fig. 3a, an interventional assembly, comprising:
The interventional catheter 100 of the present application;
The guide wire 200 is movably inserted into the interventional catheter 100, the distal end of the guide wire 200 is a working portion 210 extending out of the interventional catheter 100, and the working portion 210 moves correspondingly in the excited state of the laser fiber 150.
The guide wire 200 is a CTO guide wire 200, and is inserted into the interventional catheter 100, the distal end of the guide wire 200 is a working portion 210, when the laser fiber 150 is in an excited state under a second driving signal and acts on liquid, the liquid is agitated under the action of a discharging signal, the far end of the tube 110 is rapidly oscillated by the agitation, and when the far end of the tube 110 is oscillated, the action portion of the guide wire 200 is driven to oscillate, so that the working portion 210 can rapidly adjust the position and pass through the pores in the obstacle.
Referring to fig. 3a and 3b, the liquid chamber 140 is generally annular and disposed around the outer periphery of the tube 110. Referring to fig. 3c, the annular ring width (i.e., W in fig. 3 c) is 0.4-1.5 mm, and the annular ring width=outer circle radius-inner circle radius, referring to fig. 3c and 3d, in the present application, the annular ring width is the difference between the radius R1 corresponding to the outer circumference of the liquid chamber 140 and the outer diameter R2 of the tube body 110. Referring to fig. 3a and 3d, the liquid chamber 140 extends axially to the most distal portion of the tube body 110. The axial length of the liquid chamber 140 (see L2 in fig. 3 d) is L, and the distal end of the laser fiber 150 is 0.1 to 0.9L from the distal end of the liquid chamber 140. The axial length of the liquid chamber 140 (see L2 in fig. 3 d) is 3-15 mm. The descriptions in this paragraph are all in terms of the liquid chamber 140 being filled with liquid, and the descriptions in this paragraph also apply to the arrangement of the electrode pair 130 in the tube body 110.
Referring to fig. 3e, the outer circumference of the tube body 110 is provided with a recess 112 extending in the axial direction, and the laser fiber 150 extends along the recess 112. The recess 112 has at least two places, one of which is provided with a liquid supply tube 141 communicating with the liquid chamber 140.
Referring to fig. 3f, a coating 113 is provided on the outer periphery of the tube 110, and the coating 113 fixes the laser fiber 150 and the liquid supply tube 141 to the outer periphery of the tube 110. The coating 113 has a smooth outer peripheral surface.
Referring to fig. 3b, the distal end of the tube 110 has a reduced diameter portion, and the working bladder 120 is located in the peripheral region of the reduced diameter portion. Working bladder 120, after being filled with liquid, has a highly flush outer peripheral surface adjacent to tubular body 110. The structural description in this paragraph regarding working bladder 120 also applies to the arrangement of electrode pairs 130 in tube 110.
The number of the laser fibers 150 may be one or plural, and when the number of the laser fibers 150 is only one, the laser fibers 150 are periodically put into an excited state. The time for which the laser fiber 150 is in the excited state is 0.2s to 3s, and the time for which the laser fiber 150 is in the non-excited state is 0.5s to 1s.
When the number of the laser fibers 150 is plural, the second driving signals are received independently, and all the laser fibers 150 alternately enter the excited state. The interval time between the laser fibers 150 is 0.5s to 1s, and the time for which each of the laser fibers 150 is in the excited state is 0.2 to 3s. For example, the number of laser fibers 150 is three, A, B, C, respectively, and when a is in the excited state, B, C is in the non-excited state, B is in the excited state, A, C is in the non-excited state, C is in the excited state, A, B is in the non-excited state, and the state is switched every 0.5s to 1s, and the time for each fiber to be in the excited state is 0.2 s to 3s.
When one of the laser fibers 150 is excited, the bubbles generated on the surface of the liquid can be eliminated by the excitation of the other laser fibers 150, for example, when two laser fibers 150 are respectively a and B, the bubbles are adhered to the surface of the a when the a is in the excited state, and when the a is in the non-excited state and the B is in the excited state, the bubbles on the surface of the a can be eliminated by the excitation of the B to the liquid.
Referring to fig. 1, interventional catheter 100 further includes a handle 170 having a guidewire 200 channel 171, a fluid channel 173 for injecting a liquid into working balloon 120, and a channel 172 for receiving laser fiber 150.
Referring to fig. 4, the present application also provides an interventional device comprising:
the application intervenes in the assembly;
a driver that delivers a drive signal to the interventional component.
The driving signal is one of a first driving signal and a second driving signal.
Referring to fig. 5, the present application also provides a thrombolysis system, including:
the application intervenes in the assembly;
a driver that delivers a drive signal to the interventional component;
a thrombolysis assembly comprising a microcatheter and a thrombolytic stent delivered and retrieved by the microcatheter.
Referring to fig. 6, the thrombolytic system further comprises:
and repairing the component, and outputting therapeutic light with the wavelength range of 400-1200 nm by the light-emitting component.
The light-emitting component emits first light with the wavelength range of 400-1200 nm, and the light within the wavelength range has the function of repairing vascular endothelium and relieving smooth muscle. The wavelength of the therapeutic light has an effect on the therapeutic effect, and preferred wavelengths used include 635nm, 650nm, or 808nm.
Referring to fig. 7, the present application further provides a path establishment method during an interventional operation, including:
delivering the CTO guidewire through the interventional catheter until a distal end of the CTO guidewire reaches the site of the obstruction;
the electric field is adopted to further drive the distal end of the guide wire to pass through the obstacle part to complete the establishment of the path through the distal end part of the interventional catheter.
Referring to fig. 8, the present application further provides an interventional operation method, including:
Establishing a path, and adopting the path establishment method during the intervention operation;
Delivering the instrument along the established path and performing the corresponding operation.
The corresponding procedure is selected from at least one of delivering a therapeutic substance, thrombolysis, and endothelial repair.
The technical features of the above-described embodiments may be arbitrarily combined, and all possible combinations of the technical features in the above-described embodiments are not described for brevity of description, however, as long as there is no contradiction between the combinations of the technical features, they should be considered as the scope of the description.
The above examples illustrate only a few embodiments of the application, which are described in detail and are not to be construed as limiting the scope of the application. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the application, which are all within the scope of the application. Accordingly, the scope of protection of the present application is to be determined by the appended claims.