技术领域Technical Field
本申请涉及内窥技术领域，特别是涉及食管内窥诊疗系统和存储介质。The present application relates to the field of endoscopy technology, and in particular to an esophageal endoscopy diagnosis and treatment system and a storage medium.
背景技术Background Art
食管早癌和早期浸润癌是我国高发高危的消化道肿瘤，占全世界发病率和死亡率50%。临床早期发现和治疗边界识别是肿瘤诊断的核心和重点，而清除肿瘤与减少正常结构和功能损伤是治疗的关键和目标。目前，对消化道肿瘤的局部治疗以切除术为主，光动力疗法作为一种新型更精准的靶向选择性治疗，已临床应用于恶性肿瘤和癌前病变的治疗。在相关技术中，也有提到多种光学成像模态融合进行探测的案例，但是均未考虑食管蠕动对成像准确性带来的影响，且成像与光动力治疗无法同步，导致诊疗的准确性较差。Early esophageal cancer and early invasive cancer are high-incidence and high-risk digestive tract tumors in my country, accounting for 50% of the global morbidity and mortality. Early clinical detection and treatment boundary identification are the core and focus of tumor diagnosis, while tumor removal and reduction of normal structural and functional damage are the key and goal of treatment. At present, local treatment of digestive tract tumors is mainly resection. Photodynamic therapy, as a new and more accurate targeted selective treatment, has been clinically used in the treatment of malignant tumors and precancerous lesions. In related technologies, there are also cases of detection by fusion of multiple optical imaging modalities, but none of them considers the impact of esophageal motility on imaging accuracy, and imaging and photodynamic therapy cannot be synchronized, resulting in poor accuracy of diagnosis and treatment.
目前针对相关技术中食管内窥诊疗系统的准确性低的问题，尚未提出有效的解决方案。Currently, no effective solution has been proposed for the problem of low accuracy of esophageal endoscopic diagnosis and treatment systems in related technologies.
发明内容Summary of the invention
本申请实施例提供了一种食管内窥诊疗系统和存储介质，以至少解决相关技术中食管内窥诊疗准确性低的问题。The embodiments of the present application provide an esophageal endoscopic diagnosis and treatment system and a storage medium to at least solve the problem of low accuracy of esophageal endoscopic diagnosis and treatment in the related art.
第一方面，本申请实施例提供了一种食管内窥诊疗系统，所述系统包括：In a first aspect, an embodiment of the present application provides an esophageal endoscopic diagnosis and treatment system, the system comprising:
多模态光学内窥装置，包括多模态内窥光源、第一图像处理模块和内窥探头；所述多模态内窥光源用于发射多模态光信号，且所述多模态光信号经所述内窥探头传导；A multimodal optical endoscopy device, comprising a multimodal endoscopy light source, a first image processing module and an endoscopy probe; the multimodal endoscopy light source is used to emit a multimodal optical signal, and the multimodal optical signal is transmitted through the endoscopy probe;
适形光学平台搭建设备，包括适配所述内窥探头的导管；其中，所述内窥探头经所述导管进入人体食管；所述第一图像处理模块，用于接收所述内窥探头基于所述多模态光信号返回的，针对所述人体食管的光学成像数据，并根据所述光学成像数据生成第一成像图像；A conformal optical platform construction device, comprising a catheter adapted to the endoscopic probe; wherein the endoscopic probe enters the human esophagus through the catheter; the first image processing module is used to receive optical imaging data of the human esophagus returned by the endoscopic probe based on the multimodal optical signal, and generate a first imaging image according to the optical imaging data;
光动力治疗装置，连接所述内窥探头，用于发射治疗光信号至所述内窥探头。A photodynamic therapy device is connected to the endoscopic probe and is used to transmit a therapeutic light signal to the endoscopic probe.
在其中一些实施例中，所述系统还包括：In some embodiments, the system further comprises:
电子内窥装置，包括电子内窥光源、第二图像处理模块和搭载有所述适形光学平台搭建设备的电子内窥镜体；其中，所述导管经所述电子内窥镜体进入所述人体食管；An electronic endoscope device comprises an electronic endoscope light source, a second image processing module and an electronic endoscope body equipped with the conformal optical platform building device; wherein the catheter enters the human esophagus through the electronic endoscope body;
所述电子内窥光源用于在诊断过程中发射第一光信号；所述第一光信号经所述电子内窥镜体传导；The electronic endoscope light source is used to emit a first light signal during the diagnosis process; the first light signal is transmitted through the electronic endoscope body;
所述第二图像处理模块，用于接收经所述第一光信号返回的，针对所述人体食管的第一成像数据，并根据所述第一成像数据生成第二成像图像；The second image processing module is used to receive the first imaging data of the human esophagus returned by the first optical signal, and generate a second imaging image according to the first imaging data;
所述多模态内窥光源，还用于基于所述第二成像图像，向所述人体食管发射所述多模态光信号。The multimodal endoscopic light source is further used to transmit the multimodal light signal to the human esophagus based on the second imaging image.
在其中一些实施例中，所述电子内窥光源，还用于在光动力治疗过程中，发射第二光信号；所述第二光信号经所述电子内窥镜体传导；In some embodiments, the electronic endoscope light source is further used to emit a second light signal during photodynamic therapy; the second light signal is conducted through the electronic endoscope body;
所述第二图像处理模块还用于接收经所述第二光信号返回的，针对所述人体食管的第二成像数据，并根据所述第二成像数据生成第三成像图像；The second image processing module is further used to receive second imaging data of the human esophagus returned by the second optical signal, and generate a third imaging image according to the second imaging data;
所述光动力治疗装置，还用于基于所述第三成像图像，发射所述治疗光信号至所述内窥探头。The photodynamic therapy device is further configured to transmit the therapeutic light signal to the endoscopic probe based on the third imaging image.
在其中一些实施例中，所述电子内窥镜体上集成有大钳道；所述大钳道为内径大于预设内径阈值的钳道；In some embodiments, a large clamp channel is integrated on the electronic endoscope body; the large clamp channel is a clamp channel with an inner diameter greater than a preset inner diameter threshold;
其中，所述适形光学平台搭建设备搭载于所述大钳道，且所述导管经过所述大钳道。Wherein, the conformal optical platform construction equipment is mounted on the large clamp channel, and the catheter passes through the large clamp channel.
在其中一些实施例中，所述电子内窥镜体的一端集成有陷波滤波片；In some of the embodiments, a notch filter is integrated into one end of the electronic endoscope body;
所述陷波滤波片，用于滤除在预设波长范围内的治疗光信号。The notch filter is used to filter out therapeutic light signals within a preset wavelength range.
在其中一些实施例中，所述适形光学平台搭建设备还设置有透明支撑管道和充液机构；In some of the embodiments, the conformal optical platform construction device is further provided with a transparent support pipe and a liquid filling mechanism;
所述透明支撑管道和所述导管均呈中空结构；其中，所述透明支撑管道和所述导管内部流有第一液体介质；所述第一液体介质构成所述充液机构。The transparent support tube and the catheter are both hollow structures; wherein a first liquid medium flows inside the transparent support tube and the catheter; and the first liquid medium constitutes the liquid filling mechanism.
在其中一些实施例中，所述透明支撑管道设置有用于第一成像图像配准的刻度标记。In some of the embodiments, the transparent support tube is provided with scale marks for registration of the first imaging image.
在其中一些实施例中，所述内窥探头包括反射棱镜、超声换能器、聚焦透镜、透镜内护套和多包层光纤；In some embodiments, the endoscopic probe comprises a reflecting prism, an ultrasonic transducer, a focusing lens, an inner sheath of the lens, and a multi-clad optical fiber;
所述超声换能器为环形；其中，所述超声换能器分别连接所述反射棱镜和所述聚焦透镜；The ultrasonic transducer is annular; wherein the ultrasonic transducer is respectively connected to the reflective prism and the focusing lens;
所述聚焦透镜呈凸字阶梯结构，且所述凸字阶梯结构的第一台阶外径与所述超声换能器内孔适配；The focusing lens is in a convex step structure, and the outer diameter of the first step of the convex step structure is adapted to the inner hole of the ultrasonic transducer;
所述透镜内护套包覆于所述超声换能器和所述聚焦透镜；其中，所述超声换能器沿所述透镜内护套上开有的条形孔布置；The inner lens sheath covers the ultrasonic transducer and the focusing lens; wherein the ultrasonic transducer is arranged along the strip-shaped hole opened on the inner lens sheath;
所述多包层光纤，连接所述聚焦透镜，用于传输所述多模态光信号。The multi-clad optical fiber is connected to the focusing lens and is used to transmit the multi-modal optical signal.
在其中一些实施例中，所述内窥探头还包括透明外护套；In some of these embodiments, the endoscopic probe further comprises a transparent outer sheath;
在所述透明外护套包覆于所述内窥探头一端的情况下，在所述反射棱镜和所述超声换能器之间的间隙预充第二液体介质。When the transparent outer sheath is wrapped around one end of the endoscopic probe, the gap between the reflecting prism and the ultrasonic transducer is pre-filled with a second liquid medium.
在其中一些实施例中，所述多模态光学内窥装置还包括光电连接器、光纤耦合器和波分复用器；In some of the embodiments, the multimodal optical endoscopy device further comprises an optoelectronic connector, an optical fiber coupler, and a wavelength division multiplexer;
所述光电连接器，分别连接所述光纤耦合器和所述多包层光纤，用于带动所述内窥探头执行旋转和/或平移运动；The photoelectric connector is connected to the optical fiber coupler and the multi-clad optical fiber respectively, and is used to drive the endoscope probe to perform rotation and/or translation movement;
所述波分复用器，分别连接所述多模态内窥光源和所述光纤耦合器；The wavelength division multiplexer is connected to the multi-modal endoscopic light source and the optical fiber coupler respectively;
所述光纤耦合器，还连接所述第一图像处理模块，用于耦合所述多包层光纤内传导的多模信号和单模信号。The optical fiber coupler is also connected to the first image processing module and is used to couple the multi-mode signal and the single-mode signal transmitted in the multi-clad optical fiber.
在其中一些实施例中，所述多模态内窥光源包括光学相干断层成像(opticalcoherence tomography，简称为OCT)光源、光声光源、荧光光源和/或多模光纤光源。In some of the embodiments, the multi-modal endoscopic light source includes an optical coherence tomography (OCT) light source, a photoacoustic light source, a fluorescent light source and/or a multi-mode fiber optic light source.
第二方面，本申请实施例提供了一种存储介质，所述存储介质中存储有计算机程序，其中，所述计算机程序被设置为运行时执行上述第一方面所述的食管内窥诊疗系统的工作。In a second aspect, an embodiment of the present application provides a storage medium, in which a computer program is stored, wherein the computer program is configured to execute the operation of the esophageal endoscopic diagnosis and treatment system described in the first aspect when running.
相比于相关技术，本申请实施例提供的食管内窥诊疗系统和存储介质，其中，该系统包括：多模态光学内窥装置，包括多模态内窥光源、第一图像处理模块和内窥探头；多模态内窥光源用于发射多模态光信号，且多模态光信号经内窥探头传导；适形光学平台搭建设备，包括适配内窥探头的导管；其中，内窥探头经导管进入人体食管；第一图像处理模块，用于接收内窥探头基于多模态光信号返回的，针对人体食管的光学成像数据，并根据光学成像数据生成第一成像图像；光动力治疗装置，连接内窥探头，用于发射治疗光信号至内窥探头。基于此，通过不同模态的多模态光学内窥装置，可以综合各模态的成像特征以得到针对人体食管的全面的成像数据，有利于获取到病灶区域的组织形貌、组织分层、组织成分、细胞形态等多层次多维度信息，从而实现食管早癌的超分辨精准诊断。通过适形光学平台搭建设备建立在体稳定的适形光学平台，避免了食管不规则收缩蠕动、脏器搏动等因素引起的环境干扰，构建了在体光学诊疗的稳定环境。并且，通过将多模态成像与光动力治疗相融合，实现了针对食管早癌的在体超分辨率的诊疗一体化系统。Compared with the related art, the embodiment of the present application provides an esophageal endoscopic diagnosis and treatment system and storage medium, wherein the system includes: a multimodal optical endoscopy device, including a multimodal endoscopy light source, a first image processing module and an endoscopy probe; the multimodal endoscopy light source is used to emit a multimodal optical signal, and the multimodal optical signal is transmitted through the endoscopy probe; a conformal optical platform construction device, including a catheter adapted to the endoscopy probe; wherein the endoscopy probe enters the human esophagus through the catheter; the first image processing module is used to receive the optical imaging data of the human esophagus returned by the endoscopy probe based on the multimodal optical signal, and generate a first imaging image based on the optical imaging data; a photodynamic therapy device, connected to the endoscopy probe, is used to emit a therapeutic optical signal to the endoscopy probe. Based on this, through a multimodal optical endoscopy device of different modes, the imaging features of each mode can be integrated to obtain comprehensive imaging data for the human esophagus, which is conducive to obtaining multi-level and multi-dimensional information such as tissue morphology, tissue stratification, tissue composition, and cell morphology of the lesion area, thereby realizing super-resolution and accurate diagnosis of early esophageal cancer. By building a conformal optical platform, a stable conformal optical platform is established in vivo, avoiding environmental interference caused by factors such as irregular contraction and peristalsis of the esophagus and organ pulsation, and building a stable environment for in vivo optical diagnosis and treatment. In addition, by integrating multimodal imaging with photodynamic therapy, an in vivo super-resolution diagnosis and treatment integrated system for early esophageal cancer is realized.
本申请的一个或多个实施例的细节在以下附图和描述中提出，以使本申请的其他特征、目的和优点更加简明易懂。The details of one or more embodiments of the present application are set forth in the following drawings and description to make other features, objects, and advantages of the present application more readily apparent.
附图说明BRIEF DESCRIPTION OF THE DRAWINGS
此处所说明的附图用来提供对本申请的进一步理解，构成本申请的一部分，本申请的示意性实施例及其说明用于解释本申请，并不构成对本申请的不当限定。在附图中：The drawings described herein are used to provide a further understanding of the present application and constitute a part of the present application. The illustrative embodiments of the present application and their descriptions are used to explain the present application and do not constitute an improper limitation on the present application. In the drawings:
图1是根据本申请实施例的一种食管内窥诊疗系统的结构框图；FIG1 is a structural block diagram of an esophageal endoscopic diagnosis and treatment system according to an embodiment of the present application;
图2是根据本申请实施例的另一种食管内窥诊疗系统的结构框图；FIG2 is a structural block diagram of another esophageal endoscopy diagnosis and treatment system according to an embodiment of the present application;
图3是根据本申请实施例的一种食管内窥诊疗系统的结构示意图；FIG3 is a schematic structural diagram of an esophageal endoscopic diagnosis and treatment system according to an embodiment of the present application;
图4是根据本申请实施例的一种透明支撑管道的外形结构示意图；FIG4 is a schematic diagram of the appearance structure of a transparent support pipe according to an embodiment of the present application;
图5是根据本申请实施例的一种多模态光学内窥装置的结构示意图；FIG5 is a schematic structural diagram of a multimodal optical endoscopy device according to an embodiment of the present application;
图6是根据本申请实施例的一种透镜内护套的结构示意图；FIG6 is a schematic structural diagram of a lens inner sheath according to an embodiment of the present application;
图7是根据本申请实施例的一种内窥探头的结构示意图；FIG7 is a schematic structural diagram of an endoscope probe according to an embodiment of the present application;
图8是根据本申请实施例的另一种内窥探头的结构示意图；FIG8 is a schematic structural diagram of another endoscope probe according to an embodiment of the present application;
图9是根据本申请实施例的又一种食管内窥诊疗系统的结构框图。FIG. 9 is a structural block diagram of yet another esophageal endoscopic diagnosis and treatment system according to an embodiment of the present application.
附图标记说明：Description of reference numerals:
11、多模态光学内窥装置；111、多模态内窥光源；112、第一图像处理模块；113、内窥探头；12、适形光学平台搭建设备；121、导管；13、光动力治疗装置；21、电子内窥装置；211、电子内窥光源；212、第二图像处理模块；213、电子内窥镜体；31、大钳道；32、充液机构；33、透明支撑管道；34、第一液体介质；35、陷波滤波片；501、反射棱镜；502、超声换能器；503、聚焦透镜；504、透镜内护套；505、多包层光纤；506、扭矩弹簧；507、金属护套；508、光电连接器；509、光纤耦合器；510、波分复用器；511、OCT光源；512、光声光源；513、荧光光源；514、多模光纤光源；515、光动力治疗光源；516、第一显示器；61、条形孔；62、第一台阶；63、第二台阶；81、透明外护套；82、第二液体介质；91、第二显示器；92、人体；921、食管。11. Multimodal optical endoscopy device; 111. Multimodal endoscopy light source; 112. First image processing module; 113. Endoscopy probe; 12. Conformal optical platform construction equipment; 121. Catheter; 13. Photodynamic therapy device; 21. Electronic endoscopy device; 211. Electronic endoscopy light source; 212. Second image processing module; 213. Electronic endoscope body; 31. Large forceps channel; 32. Liquid filling mechanism; 33. Transparent support pipe; 34. First liquid medium; 35. Notch filter; 501. Reflection prism; 502. Ultrasonic transducer; 503. Focusing lens mirror; 504, lens inner sheath; 505, multi-clad optical fiber; 506, torque spring; 507, metal sheath; 508, optoelectronic connector; 509, fiber coupler; 510, wavelength division multiplexer; 511, OCT light source; 512, photoacoustic light source; 513, fluorescent light source; 514, multimode fiber light source; 515, photodynamic therapy light source; 516, first display; 61, strip hole; 62, first step; 63, second step; 81, transparent outer sheath; 82, second liquid medium; 91, second display; 92, human body; 921, esophagus.
具体实施方式DETAILED DESCRIPTION
为了使本申请的目的、技术方案及优点更加清楚明白，以下结合附图及实施例，对本申请进行描述和说明。应当理解，此处所描述的具体实施例仅仅用以解释本申请，并不用于限定本申请。基于本申请提供的实施例，本领域普通技术人员在没有作出创造性劳动的前提下所获得的所有其他实施例，都属于本申请保护的范围。此外，还可以理解的是，虽然这种开发过程中所作出的努力可能是复杂并且冗长的，然而对于与本申请公开的内容相关的本领域的普通技术人员而言，在本申请揭露的技术内容的基础上进行的一些设计，制造或者生产等变更只是常规的技术手段，不应当理解为本申请公开的内容不充分。In order to make the purpose, technical solutions and advantages of the present application clearer, the present application is described and illustrated in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present application and are not intended to limit the present application. Based on the embodiments provided in the present application, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present application. In addition, it can also be understood that although the efforts made in this development process may be complex and lengthy, for ordinary technicians in the field related to the contents disclosed in the present application, some changes such as design, manufacturing or production based on the technical contents disclosed in the present application are only conventional technical means, and should not be understood as insufficient contents disclosed in the present application.
在本申请中提及“实施例”意味着，结合实施例描述的特定特征、结构或特性可以包含在本申请的至少一个实施例中。在说明书中的各个位置出现该短语并不一定均是指相同的实施例，也不是与其它实施例互斥的独立的或备选的实施例。本领域普通技术人员显式地和隐式地理解的是，本申请所描述的实施例在不冲突的情况下，可以与其它实施例相结合。Reference to "embodiments" in this application means that a particular feature, structure, or characteristic described in conjunction with the embodiments may be included in at least one embodiment of the present application. The appearance of the phrase in various locations in the specification does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment that is mutually exclusive with other embodiments. It is explicitly and implicitly understood by those of ordinary skill in the art that the embodiments described in this application may be combined with other embodiments without conflict.
除非另作定义，本申请所涉及的技术术语或者科学术语应当为本申请所属技术领域内具有一般技能的人士所理解的通常意义。本申请所涉及的“一”、“一个”、“一种”、“该”等类似词语并不表示数量限制，可表示单数或复数。本申请所涉及的术语“包括”、“包含”、“具有”以及它们任何变形，意图在于覆盖不排他的包含；例如包含了一系列步骤或模块（单元）的过程、方法、系统、产品或设备没有限定于已列出的步骤或单元，而是可以还包括没有列出的步骤或单元，或可以还包括对于这些过程、方法、产品或设备固有的其它步骤或单元。本申请所涉及的“连接”、“相连”、“耦接”等类似的词语并非限定于物理的或者机械的连接，而是可以包括电气的连接，不管是直接的还是间接的。本申请所涉及的“多个”是指大于或者等于两个。“和/或”描述关联对象的关联关系，表示可以存在三种关系，例如，“A和/或B”可以表示：单独存在A，同时存在A和B，单独存在B这三种情况。本申请所涉及的术语“第一”、“第二”、“第三”等仅仅是区别类似的对象，不代表针对对象的特定排序。Unless otherwise defined, the technical terms or scientific terms involved in this application should be understood by people with ordinary skills in the technical field to which this application belongs. The words "one", "a", "a", "the" and the like involved in this application do not indicate a quantitative limitation and may represent the singular or plural. The terms "include", "comprise", "have" and any of their variations involved in this application are intended to cover non-exclusive inclusions; for example, a process, method, system, product or device that includes a series of steps or modules (units) is not limited to the listed steps or units, but may also include unlisted steps or units, or may also include other steps or units inherent to these processes, methods, products or devices. The words "connect", "connected", "coupled" and the like involved in this application are not limited to physical or mechanical connections, but may include electrical connections, whether direct or indirect. The "multiple" involved in this application means greater than or equal to two. "And/or" describes the association relationship of associated objects, indicating that there can be three relationships. For example, "A and/or B" can mean: A exists alone, A and B exist at the same time, and B exists alone. The terms "first", "second", "third" and the like involved in the present application are merely used to distinguish similar objects and do not represent a specific ordering of the objects.
本实施例提供了一种食管内窥诊疗系统，图1是根据本申请实施例的一种食管内窥诊疗系统的结构框图，如图1所示，该系统包括：多模态光学内窥装置11、适形光学平台搭建设备12和光动力治疗装置13。This embodiment provides an esophageal endoscopic diagnosis and treatment system. Figure 1 is a structural block diagram of an esophageal endoscopic diagnosis and treatment system according to an embodiment of the present application. As shown in Figure 1, the system includes: a multimodal optical endoscopy device 11, a conformal optical platform building device 12 and a photodynamic therapy device 13.
多模态光学内窥装置11，包括多模态内窥光源111、第一图像处理模块112和内窥探头113；多模态内窥光源111用于发射多模态光信号，且多模态光信号经内窥探头113传导。上述多模态光学内窥装置11是指多个通过不同模态的光信号对目标对象进行探测成像的光学内窥装置。也即，该多模态光学内窥装置11中的多模态内窥光源111可以包括但不限于各种OCT光源、光声光源、荧光光源或多模光纤光源中的至少一种。需要说明的是，在本实施例中，将OCT光源、光声光源、荧光光源、多模光纤光源等多模态内窥光源111融合进同一个内窥探头，并经由该内窥探头将各模态的光信号传导至目标位置。The multimodal optical endoscopy device 11 includes a multimodal endoscopy light source 111, a first image processing module 112 and an endoscopy probe 113; the multimodal endoscopy light source 111 is used to emit a multimodal optical signal, and the multimodal optical signal is transmitted through the endoscopy probe 113. The above-mentioned multimodal optical endoscopy device 11 refers to a plurality of optical endoscopy devices that detect and image a target object through optical signals of different modes. That is, the multimodal endoscopy light source 111 in the multimodal optical endoscopy device 11 may include but is not limited to at least one of various OCT light sources, photoacoustic light sources, fluorescent light sources or multimode optical fiber light sources. It should be noted that in this embodiment, the multimodal endoscopy light source 111 such as the OCT light source, photoacoustic light source, fluorescent light source, multimode optical fiber light source, etc. are integrated into the same endoscopy probe, and the optical signals of each mode are transmitted to the target position through the endoscopy probe.
则上述第一图像处理模块112也可以相应设置有多个，每个第一图像处理模块112与一个多模态内窥光源111相对应，用于处理由该多模态内窥光源111发射的光信号返回的成像数据，并进行图像配准融合；或者，在实施例允许的情况下，也可以由多个多模态内窥光源111共用同一个第一图像处理模块112，即通过该第一图像处理模块112实现对多模态光信号的集中处理并生成组织图像，以提高数据处理的效率，同时进一步简化诊疗系统的结构。The above-mentioned first image processing module 112 may also be correspondingly provided with multiple ones, each first image processing module 112 corresponding to a multimodal endoscopic light source 111, for processing the imaging data returned by the light signal emitted by the multimodal endoscopic light source 111, and performing image registration and fusion; or, if permitted by the embodiment, multiple multimodal endoscopic light sources 111 may also share the same first image processing module 112, that is, the first image processing module 112 is used to realize centralized processing of multimodal light signals and generate tissue images, so as to improve the efficiency of data processing and further simplify the structure of the diagnosis and treatment system.
其中，OCT成像获取组织反射率的图像，可对1mm深度的组织进行成像,其轴向分辨率可达8μm，横向分辨率为20μm，够观测到黏膜表面以下的病变，但不具备分子特异性；光声成像利用组织对光信号的吸收特性，探测光声信号能重建出组织中的光吸收分布图像，避免了光散射的影响，可对1-4mm的食管组织进行成像；荧光成像具有较高的分子特异性和较高的灵敏度，但其成像需要依靠相应的荧光剂标记；多模光纤成像利用多模光纤进行照明光的传输及调制，能够在保持极细探头直径的同时提供很高的分辨率，其分辨率可达亚微米级别，可实现在体的无标记超分辨成像，这与荧光成像需要标记不同；通过获取OCT、光声、荧光、多模光纤等多模态的图像数据，并进行图像配准融合，可以精准表征组织形貌、血管分布、组织结构、细胞形态等生物信息，实现早癌的在体超分辨精准诊断。Among them, OCT imaging obtains images of tissue reflectivity and can image tissues at a depth of 1mm. Its axial resolution can reach 8μm and its lateral resolution is 20μm, which can observe lesions below the mucosal surface, but it does not have molecular specificity. Photoacoustic imaging uses the absorption characteristics of tissues to light signals. Detecting photoacoustic signals can reconstruct the light absorption distribution image in the tissue, avoiding the influence of light scattering, and can image esophageal tissues of 1-4mm. Fluorescence imaging has high molecular specificity and high sensitivity, but its imaging requires corresponding fluorescent agent labeling. Multimode fiber imaging uses multimode optical fiber to transmit and modulate illumination light, which can provide high resolution while maintaining an extremely fine probe diameter. Its resolution can reach submicron level, and can achieve in vivo label-free super-resolution imaging, which is different from fluorescence imaging that requires labeling. By acquiring multimodal image data such as OCT, photoacoustic, fluorescence, and multimode optical fiber, and performing image registration and fusion, biological information such as tissue morphology, vascular distribution, tissue structure, and cell morphology can be accurately characterized, and in vivo super-resolution and accurate diagnosis of early cancer can be achieved.
适形光学平台搭建设备12，包括适配内窥探头113的导管121；其中，内窥探头113经导管121进入人体食管；第一图像处理模块112，用于接收内窥探头113基于多模态光信号返回的，针对人体食管的光学成像数据，并根据光学成像数据生成第一成像图像。The conformal optical platform building device 12 includes a catheter 121 adapted for the endoscopic probe 113; wherein the endoscopic probe 113 enters the human esophagus through the catheter 121; the first image processing module 112 is used to receive optical imaging data of the human esophagus returned by the endoscopic probe 113 based on the multimodal optical signal, and generate a first imaging image according to the optical imaging data.
食管是人体消化管道的一部分，上连于咽，沿脊柱椎体下行，穿过膈肌的食管裂孔通入胃。针对食管早癌的内窥诊断至关重要，然而，由于人体食管存在不规则收缩蠕动以及脏器搏动易引起环境干扰等客观因素，难以为内窥诊疗提供稳定环境，容易影响食管内窥诊疗的准确性。因此，为了改善上述问题，在本实施例中，提供了至少包括导管121的适形光学平台搭建设备12，该导管121在轴向上呈中空结构，且内部搭载有与其适配的内窥探头113。在诊疗过程中，导管121可以耦合进人体食管，以便在体建立适形光学平台。更具体而言，在通过上述结构搭建稳定的适形光学平台搭建设备之后，在内窥诊断过程中，由第一图像处理模块112接收内窥探头113返回的针对人体食管的光学成像数据，并对其进行图像处理，获取针对该人体食管的成像图像。应当理解地，上述第一成像图像可以通过多模态光学内窥装置11中的第一显示器，向操作人员实时展示。The esophagus is part of the human digestive tract, connected to the pharynx, descending along the vertebral body of the spine, and passing through the esophageal hiatus of the diaphragm into the stomach. Endoscopic diagnosis of early esophageal cancer is crucial. However, due to objective factors such as irregular contraction and peristalsis of the human esophagus and organ pulsation that easily cause environmental interference, it is difficult to provide a stable environment for endoscopic diagnosis and treatment, which easily affects the accuracy of esophageal endoscopic diagnosis and treatment. Therefore, in order to improve the above problems, in this embodiment, a conformal optical platform construction device 12 is provided, which includes at least a catheter 121. The catheter 121 is a hollow structure in the axial direction, and an endoscopic probe 113 adapted thereto is carried inside. During the diagnosis and treatment process, the catheter 121 can be coupled into the human esophagus to establish a conformal optical platform in the body. More specifically, after a stable conformal optical platform construction device is built by the above structure, during the endoscopic diagnosis process, the first image processing module 112 receives the optical imaging data of the human esophagus returned by the endoscopic probe 113, and performs image processing on it to obtain an imaging image of the human esophagus. It should be understood that the first imaging image can be displayed to the operator in real time through the first display in the multimodal optical endoscopy device 11 .
光动力治疗装置13，连接内窥探头113，用于发射治疗光信号至内窥探头113。需要补充说明的是，在相关技术中，通常是将内窥诊疗通道中放入独立的成像探头和治疗探头；但是该途径依赖于手动操作来对病灶进行激光消融等治疗，且由于成像和治疗探头运动不同步等原因易造成诊断和治疗的过程匹配性差，存在较大的监测误差，影响治疗效果。基于此，在本实施例中，将光动力治疗装置13与多模态光学内窥装置11共用一个内窥探头113，并且，在一体化诊疗过程中，可以通过内窥探头113传输多种多模态成像光信号，同时通过该内窥探头113中传输治疗光信号。可见，通过上述共用同一个内窥探头113的系统结构，在利用多模态光学内窥装置11进行精准诊断后，通过切换多模态内窥光源和光动力治疗光源即可完成诊断和治疗的切换，而无需拔出多模态内窥探头113，可以实现能同时传输多模态成像光信号和治疗光信号的诊疗一体化系统设计，治疗过程中的检测以及治疗后的评估能够同时进行。通过上述方式，从而避免了诊断的病变位置与光学治疗位置之间存在错位导致的光学内窥诊疗系统的准确性低的现象，减少了监测误差，使得能够在体超分辨精准诊断的多模态成像与光动力治疗进行融合，且诊断和疗效监控系统、以及治疗系统共用一个内窥探头，有效提高食管内窥诊疗系统的一体化诊疗精度和效率，进而提高了对于食管早癌患者诊断率、治愈率以及患者的适应性。The photodynamic therapy device 13 is connected to the endoscopic probe 113 and is used to transmit a therapeutic light signal to the endoscopic probe 113. It should be supplemented that in the related art, independent imaging probes and therapeutic probes are usually placed in the endoscopic diagnosis and treatment channel; however, this approach relies on manual operation to perform laser ablation and other treatments on the lesions, and due to the asynchronous movement of the imaging and treatment probes, it is easy to cause poor matching of the diagnosis and treatment processes, and there are large monitoring errors, which affect the treatment effect. Based on this, in this embodiment, the photodynamic therapy device 13 and the multimodal optical endoscope device 11 share an endoscope probe 113, and in the integrated diagnosis and treatment process, a variety of multimodal imaging light signals can be transmitted through the endoscope probe 113, and the therapeutic light signal can be transmitted through the endoscope probe 113 at the same time. It can be seen that, through the above-mentioned system structure that shares the same endoscopic probe 113, after accurate diagnosis is performed using the multimodal optical endoscope device 11, the switching between diagnosis and treatment can be completed by switching the multimodal endoscope light source and the photodynamic therapy light source, without pulling out the multimodal endoscope probe 113, and the integrated diagnosis and treatment system design that can simultaneously transmit multimodal imaging light signals and treatment light signals can be realized, and the detection during the treatment process and the evaluation after the treatment can be carried out at the same time. Through the above-mentioned method, the phenomenon of low accuracy of the optical endoscope diagnosis and treatment system caused by the misalignment between the diagnosed lesion position and the optical treatment position is avoided, the monitoring error is reduced, and the multimodal imaging and photodynamic therapy that can be accurately diagnosed in vivo with super-resolution are integrated, and the diagnosis and efficacy monitoring system, as well as the treatment system share an endoscope probe, which effectively improves the integrated diagnosis and treatment accuracy and efficiency of the esophageal endoscope diagnosis and treatment system, thereby improving the diagnosis rate, cure rate and patient adaptability for patients with early esophageal cancer.
通过上述实施例中，提供了至少包括多模态光学内窥装置11、适形光学平台搭建设备12和光动力治疗装置13的食管内窥诊疗系统；通过不同模态的多模态光学内窥装置11，可以综合各模态的成像特征以得到针对人体食管的全面的成像数据，有利于获取到病灶区域的组织形貌、组织分层、组织成分、细胞形态等多层次多维度信息，从而实现食管早癌的超分辨精准诊断。通过适形光学平台搭建设备12建立在体稳定的适形光学平台，避免了食管不规则收缩蠕动、脏器搏动等因素引起的环境干扰，构建了在体光学诊疗的稳定环境。并且，通过将多模态成像与光动力治疗相融合，实现了针对食管早癌的在体超分辨率的诊疗一体化系统。Through the above embodiments, an esophageal endoscopic diagnosis and treatment system including at least a multimodal optical endoscope device 11, a conformal optical platform construction device 12 and a photodynamic therapy device 13 is provided; through the multimodal optical endoscope device 11 of different modes, the imaging characteristics of each mode can be integrated to obtain comprehensive imaging data for the human esophagus, which is conducive to obtaining multi-level and multi-dimensional information such as tissue morphology, tissue stratification, tissue composition, and cell morphology in the lesion area, thereby realizing super-resolution and accurate diagnosis of early esophageal cancer. By establishing a stable conformal optical platform in vivo through the conformal optical platform construction device 12, environmental interference caused by factors such as irregular contraction and peristalsis of the esophagus and organ pulsation is avoided, and a stable environment for in vivo optical diagnosis and treatment is constructed. In addition, by integrating multimodal imaging with photodynamic therapy, an in vivo super-resolution diagnosis and treatment integrated system for early esophageal cancer is realized.
在其中一些实施例中，还提供了一种食管内窥诊疗系统，请参阅图2，该系统还包括电子内窥装置21。In some of the embodiments, an esophageal endoscopic diagnosis and treatment system is also provided, please refer to FIG. 2 , and the system also includes an electronic endoscopic device 21 .
电子内窥装置21，包括电子内窥光源211、第二图像处理模块212和搭载有适形光学平台搭建设备12的电子内窥镜体213；其中，导管121经电子内窥镜体213进入人体食管。换言之，电子内窥装置21的电子内窥镜体213能够深入人体食管内部，并由第二图像处理模块212通过高分辨率的成像技术，获取肿瘤在不同尺度上的光学信息。The electronic endoscope device 21 includes an electronic endoscope light source 211, a second image processing module 212, and an electronic endoscope body 213 equipped with a conformal optical platform building device 12; wherein the catheter 121 enters the human esophagus through the electronic endoscope body 213. In other words, the electronic endoscope body 213 of the electronic endoscope device 21 can penetrate into the human esophagus, and the second image processing module 212 can obtain optical information of the tumor at different scales through high-resolution imaging technology.
下面对诊断过程中电子内窥装置21中各部件的工作流程进行简要说明：上述电子内窥光源211在诊断过程中发射第一光信号；第一光信号经电子内窥镜体213传导；该电子内窥光源211可以包括氙灯光源或LED光源等，以确保在内窥检查过程中能够提供稳定且高质量的照明。该过程中，由电子内窥镜体负责将电子内窥光源发出的光线，即第一光信号传导到待观察的人体食管部位，并捕捉反射回来的图信号。第二图像处理模块212接收电子内窥镜体213经第一光信号返回的，针对人体食管的第一成像数据，并根据第一成像数据生成第二成像图像。应当理解地，该第二成像图像可以在电子内窥装置21的第二显示器上进行展示，以供操作人员实时观察和分析。则上述多模态内窥光源111，还可以基于第二成像图像，向人体食管发射多模态光信号。更具体而言，多模态光学内窥装置11，可以根据由电子内窥装置21初检获取的针对食管病灶组织的跨尺度光学信息，实时调整诊断过程中多模态内窥光源111发射的多模态光信号，进而实现更为精确的食管内窥诊断。The following is a brief description of the workflow of each component in the electronic endoscope device 21 during the diagnosis process: the electronic endoscope light source 211 emits a first light signal during the diagnosis process; the first light signal is transmitted through the electronic endoscope body 213; the electronic endoscope light source 211 may include a xenon light source or an LED light source, etc., to ensure that stable and high-quality lighting can be provided during the endoscopic examination. In this process, the electronic endoscope body is responsible for transmitting the light emitted by the electronic endoscope light source, that is, the first light signal, to the human esophageal part to be observed, and capturing the reflected image signal. The second image processing module 212 receives the first imaging data of the human esophagus returned by the electronic endoscope body 213 through the first light signal, and generates a second imaging image based on the first imaging data. It should be understood that the second imaging image can be displayed on the second display of the electronic endoscope device 21 for real-time observation and analysis by the operator. Then the multimodal endoscope light source 111 can also emit a multimodal light signal to the human esophagus based on the second imaging image. More specifically, the multimodal optical endoscopy device 11 can adjust the multimodal light signal emitted by the multimodal endoscopy light source 111 during the diagnosis process in real time according to the cross-scale optical information of the esophageal lesion tissue obtained by the electronic endoscopy device 21 during the initial inspection, thereby achieving more accurate esophageal endoscopy diagnosis.
在另一实施例中，对治疗过程中电子内窥装置21中各部件的工作流程进行简要说明：上述电子内窥光源211在光动力治疗过程中，发射第二光信号；第二光信号经电子内窥镜体传导；第二图像处理模块212接收经第二光信号返回的，针对人体食管的第二成像数据，并根据第二成像数据生成第三成像图像。与上述诊断过程相类似，第二图像处理模块212接收电子内窥镜体213返回的第二成像数据，对其进行图像处理并生成第三成像图像，该第三成像图像可以在第二显示器上进行显示，以实现在治疗过程中的实时监测。则上述光动力治疗装置13，还可以基于第三成像图像，发射治疗光信号至内窥探头。具体地，该光动力治疗装置13可以基于该治疗过程中电子内窥装置21实时显示的第三成像图像及时进行调整，包括调整光敏剂浓度、光照剂量等参数，发射相应的治疗光信号进行治疗，有利于提高光动力治疗的准确性。In another embodiment, the workflow of each component in the electronic endoscope device 21 during the treatment process is briefly described: the above-mentioned electronic endoscope light source 211 emits a second light signal during the photodynamic therapy process; the second light signal is transmitted through the electronic endoscope body; the second image processing module 212 receives the second imaging data of the human esophagus returned by the second light signal, and generates a third imaging image based on the second imaging data. Similar to the above-mentioned diagnosis process, the second image processing module 212 receives the second imaging data returned by the electronic endoscope body 213, performs image processing on it and generates a third imaging image, which can be displayed on the second display to achieve real-time monitoring during the treatment process. Then the above-mentioned photodynamic therapy device 13 can also emit a therapeutic light signal to the endoscope probe based on the third imaging image. Specifically, the photodynamic therapy device 13 can be adjusted in time based on the third imaging image displayed in real time by the electronic endoscope device 21 during the treatment process, including adjusting parameters such as photosensitizer concentration and light dose, and emitting a corresponding therapeutic light signal for treatment, which is conducive to improving the accuracy of photodynamic therapy.
通过上述实施例，通过电子内窥装置21，获取对于人体食管肿瘤组织的跨尺度光学信息以及光动力量效信息，从而实现了全程可视化监测功能，进一步有效提高了针对人体食管的在体诊疗准确性。Through the above-mentioned embodiment, the cross-scale optical information and photodynamic efficiency information of the human esophageal tumor tissue are obtained through the electronic endoscope device 21, thereby realizing the full-process visual monitoring function, and further effectively improving the accuracy of in vivo diagnosis and treatment of the human esophagus.
在其中一些实施例中，上述电子内窥镜体213上集成有大钳道；该大钳道为内径大于预设内径阈值的钳道。其中，大钳道是指镜体前端部分的钳道直径与整个镜体前端直径的比例，即钳径比大于某一阈值。钳道越大，头端直径越小，钳径比就越大，也越能方便内窥系统可以穿过狭窄曲折的通道，尽量深入到人体食管等区域来实现更精准的观察和治疗。特别地，在本实施例中，大钳道的内径≥3.2 mm。In some of the embodiments, a large clamp channel is integrated on the electronic endoscope body 213; the large clamp channel is a clamp channel with an inner diameter greater than a preset inner diameter threshold. Among them, the large clamp channel refers to the ratio of the clamp channel diameter of the front end part of the scope body to the diameter of the front end of the entire scope body, that is, the clamp diameter ratio is greater than a certain threshold. The larger the clamp channel, the smaller the diameter of the head end, the larger the clamp diameter ratio, and the more convenient it is for the endoscope system to pass through narrow and tortuous channels and try to penetrate into areas such as the human esophagus to achieve more accurate observation and treatment. In particular, in this embodiment, the inner diameter of the large clamp channel is ≥3.2 mm.
上述适形光学平台搭建设备搭载于大钳道，且该适形光学平台搭建设备的导管经过大钳道耦合进人体食管。作为示例，请参阅图3，图中示出了关于食管内窥诊疗系统中各装置间的耦合装配方式。其中，电子内窥镜体213上集成有大钳道31；适形光学平台搭建设备的导管121穿过该大钳道31进入人体食管，且导管121内部搭载有上述内窥探头113。The conformal optical platform construction device is mounted on the large clamp channel, and the catheter of the conformal optical platform construction device is coupled into the human esophagus through the large clamp channel. As an example, please refer to Figure 3, which shows the coupling assembly method between the various devices in the esophageal endoscopic diagnosis and treatment system. Among them, the electronic endoscope body 213 is integrated with a large clamp channel 31; the catheter 121 of the conformal optical platform construction device passes through the large clamp channel 31 to enter the human esophagus, and the catheter 121 is equipped with the above-mentioned endoscopic probe 113.
在其中一些实施例中，上述电子内窥镜体的一端集成有陷波滤波片；该陷波滤波片，用于滤除在预设波长范围内的治疗光信号，同时保留其他不受影响的波长的治疗激光。应当理解地，可滤除的预设波长范围与陷波滤波片的选材有关；在本实施例中，该陷波滤波片的滤波范围可以是630 nm波长范围。请参阅图3，图中示出了一种陷波滤波片的安装方式；其中，该陷波滤波片35布置在电子内窥镜体前端成像通道位置处，能够滤除光动力治疗装置13发出的630nm波长的激光（实际透过率＜1%）。通过这一巧妙、简便的设计结构，有效解决了光动力强光照明下引起的盲视问题，实现光动力可视，进而能对光斑边界、肿瘤边界和治疗效应实时显示。In some of the embodiments, a notch filter is integrated at one end of the electronic endoscope body; the notch filter is used to filter out the therapeutic light signal within the preset wavelength range while retaining other unaffected wavelengths of therapeutic laser. It should be understood that the preset wavelength range that can be filtered is related to the material selection of the notch filter; in this embodiment, the filtering range of the notch filter can be a 630 nm wavelength range. Please refer to Figure 3, which shows a method for installing a notch filter; wherein the notch filter 35 is arranged at the imaging channel position at the front end of the electronic endoscope body, and can filter out the 630nm wavelength laser emitted by the photodynamic therapy device 13 (actual transmittance <1%). Through this ingenious and simple design structure, the blindness problem caused by strong photodynamic light illumination is effectively solved, and photodynamic visualization is achieved, so that the spot boundary, tumor boundary and treatment effect can be displayed in real time.
在其中一些实施例中，上述适形光学平台搭建设备还设置有透明支撑管道和充液机构；透明支撑管道和导管均呈中空结构，且透明支撑管道内部搭载有导管；充液机构，用于向透明支撑管道和导管内部流入第一液体介质。在本实施例中，第一液体介质可以采用造影剂碘溶液或重水，用于实现系统中光声信号通路的建立。In some embodiments, the conformal optical platform construction device is further provided with a transparent support pipe and a liquid filling mechanism; the transparent support pipe and the catheter are both hollow structures, and the transparent support pipe is equipped with a catheter; the liquid filling mechanism is used to flow a first liquid medium into the transparent support pipe and the catheter. In this embodiment, the first liquid medium can be a contrast agent iodine solution or heavy water, which is used to establish a photoacoustic signal path in the system.
请参阅图3，充液机构32设置在位于大钳道侧的适形光学平台搭建设备上，该机构无需进入食管。在实际应用过程中，在充液机构32的作用下，沿导管121布置路径，向前端的透明支撑管道33和导管121注入一定流量的第一液体介质。通过充液机构32向透明支撑管道33和导管内部流入第一液体介质34，使得在第一液体介质34充入后能够改变透明支撑管道33形状，使其可以更好地贴紧目标部位，如食管。通过充液机构32控制第一液体介质34的注入，能够具备较高的注入控制精度，以确保第一液体介质34能够准确地注入到指定位置，并在需要时停止注入，有助于避免过量注入导致的浪费和潜在风险。当透明支撑管道33和导管121内部充入第一液体介质34时，该透明支撑管道33在第一液体介质34的作用在能够紧贴食管，以实现应用时撑开人体食管的工作，进而为导管提供稳定的支撑和定位，便于搭建稳定的在体适形光学平台。并且，在这一状态下，导管121与透明支撑管道33间的同心度应当小于预设的同心度阈值，以确保良好的系统精度；该同心度阈值可以根据实际情况进行设置，例如可以设置为200μm。需要补充说明的是，当透明支撑管道33和导管121处于未充液体状态下，透明支撑管道33会自动收缩折叠并紧贴导管121外壁。当透明支撑管道33内部流有第一液体介质时，其外径为20 mm，未充液体时收缩状态下其外径小于2.9 mm。其中，透明支撑管道33可以采用PET或PA12等可形变、高透明度的高分子材料，导管121可以采用高透明的pebax高分子材料，应当确保光透过率大于95%，以承受体内环境并保持优异的光学性能。Please refer to Figure 3. The filling mechanism 32 is arranged on the conformal optical platform construction device located on the side of the large clamp channel, and the mechanism does not need to enter the esophagus. In actual application, under the action of the filling mechanism 32, a path is arranged along the catheter 121, and a certain flow of the first liquid medium is injected into the transparent support pipe 33 and the catheter 121 at the front end. The first liquid medium 34 flows into the transparent support pipe 33 and the catheter through the filling mechanism 32, so that the shape of the transparent support pipe 33 can be changed after the first liquid medium 34 is filled, so that it can better fit the target part, such as the esophagus. By controlling the injection of the first liquid medium 34 through the filling mechanism 32, a higher injection control accuracy can be achieved to ensure that the first liquid medium 34 can be accurately injected into the specified position, and the injection can be stopped when necessary, which helps to avoid waste and potential risks caused by excessive injection. When the transparent support tube 33 and the catheter 121 are filled with the first liquid medium 34, the transparent support tube 33 can be close to the esophagus in the first liquid medium 34 to achieve the work of opening the human esophagus during application, thereby providing stable support and positioning for the catheter, which is convenient for building a stable in-body conformal optical platform. Moreover, in this state, the concentricity between the catheter 121 and the transparent support tube 33 should be less than the preset concentricity threshold to ensure good system accuracy; the concentricity threshold can be set according to actual conditions, for example, it can be set to 200μm. It should be supplemented that when the transparent support tube 33 and the catheter 121 are not filled with liquid, the transparent support tube 33 will automatically shrink and fold and cling to the outer wall of the catheter 121. When the first liquid medium flows inside the transparent support tube 33, its outer diameter is 20 mm, and its outer diameter is less than 2.9 mm in the contracted state when it is not filled with liquid. Among them, the transparent supporting tube 33 can be made of deformable and highly transparent polymer materials such as PET or PA12, and the catheter 121 can be made of highly transparent pebax polymer material. The light transmittance should be ensured to be greater than 95% to withstand the in vivo environment and maintain excellent optical properties.
通过上述实施例，通过在透明支撑管道33和导管121内部充入第一液体介质，能够充盈整个透明支撑管道33，使其在实际应用时能够紧贴人体食管，便于建立光声成像回路，为光声成像等高精度操作提供了可靠保障，不仅确保了成像或治疗过程中的稳定性，还有利于提高成像质量或治疗效果。Through the above embodiment, by filling the first liquid medium into the transparent support tube 33 and the catheter 121, the entire transparent support tube 33 can be filled, so that it can be close to the human esophagus in actual application, which is convenient for establishing a photoacoustic imaging circuit, and provides reliable protection for high-precision operations such as photoacoustic imaging, which not only ensures the stability during imaging or treatment, but also helps to improve imaging quality or treatment effect.
在其中一些实施例中，上述透明支撑管道设置有用于第一成像图像配准的刻度标记。上述结构请参阅图4，为了更好的进入食管并适应食管形态，方便在体搭建适形光学平台，该透明支撑管道设计为两端直径小于中部直径一定比例的结构。同时该透明支撑管道上印有刻度标记，可用于轴向和周向的多模态图像数据之间的配准。其中，该刻度标记允许操作人员在操作过程中准确地定位透明支撑管道在体位置。并且，通过刻度标记，可以建立一个统一的坐标系，将不同模态的图像数据映射到这个坐标系上。这样，即使图像数据来源于不同模态的光源或不同的成像技术，也能够在这个统一坐标系中进行比对和分析。In some of the embodiments, the transparent support pipe is provided with scale marks for the first imaging image registration. Please refer to Figure 4 for the above structure. In order to better enter the esophagus and adapt to the morphology of the esophagus, and to facilitate the construction of a conformal optical platform in the body, the transparent support pipe is designed to be a structure in which the diameters of both ends are smaller than a certain proportion of the middle diameter. At the same time, scale marks are printed on the transparent support pipe, which can be used for the registration between axial and circumferential multimodal image data. Among them, the scale marks allow the operator to accurately locate the position of the transparent support pipe in the body during the operation. In addition, through the scale marks, a unified coordinate system can be established to map image data of different modes to this coordinate system. In this way, even if the image data comes from light sources of different modes or different imaging technologies, they can be compared and analyzed in this unified coordinate system.
可见，通过在适形光学平台搭建设备12的透明支撑管道上印有刻度标记的设计，在多模态图像数据配准中起到了重要作用；这种刻度标记不仅为操作人员提供了直观的参考依据，还极大地提高了图像配准的精度和效率。另外，传统的图像配准过程可能需要复杂的算法和大量的计算资源。而有了刻度标记的辅助，操作人员可以通过简单的观察和操作就能完成初步的配准工作，从而简化了整个操作流程。It can be seen that the design of printing scale marks on the transparent support pipe of the conformal optical platform building device 12 plays an important role in the multimodal image data registration; this scale mark not only provides an intuitive reference for operators, but also greatly improves the accuracy and efficiency of image registration. In addition, the traditional image registration process may require complex algorithms and a large amount of computing resources. With the assistance of scale marks, operators can complete the preliminary registration work through simple observation and operation, thereby simplifying the entire operation process.
在其中一些实施例中，上述内窥探头包括反射棱镜、超声换能器、聚焦透镜、透镜内护套和多包层光纤。为了便于理解，下面结合图5和图6对本申请实施例的内窥探头结构进行说明。In some embodiments, the endoscopic probe includes a reflective prism, an ultrasonic transducer, a focusing lens, a lens inner sheath and a multi-clad optical fiber. For ease of understanding, the structure of the endoscopic probe of the embodiment of the present application is described below in conjunction with FIG. 5 and FIG. 6 .
上述超声换能器为环形；其中，超声换能器分别连接反射棱镜和聚焦透镜。请参阅图5，该反射棱镜501是一种横截面为三角形的棱镜，在内窥探头113中，反射棱镜501可以接收来自光源的光线，并将其按照预定的路径反射到成像区域，从而确保光线能够高效地传输到目标位置。同时利用反射棱镜501可以减少反光干扰：由于内窥探头113的工作环境往往较为复杂，光线干扰是一个常见问题；反射棱镜501可以通过其特殊的光学设计，减少光线在探头内部的反射和散射，从而降低反光干扰，提高成像质量。该反射棱镜501与超声换能器502耦合装配。超声换能器502是一种将电磁能转化为机械能（声能）的装置；通过内窥探头113中超声换能器502发射的超声波，操作人员可以清晰地观察到人体内部的结构和病变情况，为食管早癌的诊断和治疗提供重要依据。在本实施例中，为了便于各部件之间能够吻合装配，将超声换能器502设计为横截面呈环形状的结构体，且其表面尺寸设定为1.8mm×0.9mm（外径×内径）。The ultrasonic transducer is annular; wherein the ultrasonic transducer is connected to a reflective prism and a focusing lens respectively. Referring to FIG5 , the reflective prism 501 is a prism with a triangular cross section. In the endoscope probe 113, the reflective prism 501 can receive light from a light source and reflect it to an imaging area according to a predetermined path, thereby ensuring that the light can be efficiently transmitted to the target position. At the same time, the reflective prism 501 can reduce reflection interference: since the working environment of the endoscope probe 113 is often more complex, light interference is a common problem; the reflective prism 501 can reduce the reflection and scattering of light inside the probe through its special optical design, thereby reducing reflection interference and improving imaging quality. The reflective prism 501 is coupled and assembled with an ultrasonic transducer 502. The ultrasonic transducer 502 is a device that converts electromagnetic energy into mechanical energy (acoustic energy); through the ultrasonic wave emitted by the ultrasonic transducer 502 in the endoscope probe 113, the operator can clearly observe the structure and pathological conditions inside the human body, providing an important basis for the diagnosis and treatment of early esophageal cancer. In this embodiment, in order to facilitate the fitting and assembly of various components, the ultrasonic transducer 502 is designed as a structure with a ring-shaped cross section, and its surface size is set to 1.8 mm×0.9 mm (outer diameter×inner diameter).
聚焦透镜503，用于将光源光束聚焦于一点或某一特定焦平面上，从而提高内窥成像清晰度。以图5为例，该聚焦透镜503的横截面呈凸字阶梯结构，且凸字阶梯结构的第一台阶外径与超声换能器502内孔适配，使得该聚焦透镜503的一端刚好能够卡进超声换能器502中，并一起组装到透镜内护套504中。透镜内护套504包覆于超声换能器502和聚焦透镜503表面。请参阅图6，图中示出了透镜内护套表面结构，以及装配有超声换能器和聚焦透镜的透镜内部横截面结构。其中，超声换能器502沿透镜内护套504上开有的条形孔61布置。该聚焦透镜503至少包括第一台阶62和第二台阶63，其中，该第一台阶62与超声换能器502的结构相适配。The focusing lens 503 is used to focus the light beam of the light source on a point or a specific focal plane, so as to improve the clarity of the endoscopic imaging. Taking FIG5 as an example, the cross section of the focusing lens 503 is a convex step structure, and the outer diameter of the first step of the convex step structure is adapted to the inner hole of the ultrasonic transducer 502, so that one end of the focusing lens 503 can just be inserted into the ultrasonic transducer 502 and assembled together into the lens inner sheath 504. The lens inner sheath 504 is coated on the surface of the ultrasonic transducer 502 and the focusing lens 503. Please refer to FIG6, which shows the surface structure of the lens inner sheath and the internal cross-sectional structure of the lens equipped with the ultrasonic transducer and the focusing lens. Among them, the ultrasonic transducer 502 is arranged along the strip hole 61 opened on the lens inner sheath 504. The focusing lens 503 includes at least a first step 62 and a second step 63, wherein the first step 62 is adapted to the structure of the ultrasonic transducer 502.
多包层光纤505，连接聚焦透镜503，用于传输多模态光信号。其中，多包层光纤505包括纤芯以及包围纤芯的至少两个包层结构。通过多包层光纤505可以同时传输成像光信号和治疗光信号，且该成像光信号和该治疗光信号在传输过程中互不干扰。在本实施例中，该多包层光纤505可以采用双包层光纤；其中，该双包层光纤包括纤芯、内包层和外包层护套。其纤芯直径为9μm，用于传输1310nm的单模光信号；当然，如需传输840nm的单模光信号，其纤芯直径可相应调整。其内包层直径为105μm，用于传输405nm、488nm、532nm、630nm等不同波长的多模光信号。The multi-clad optical fiber 505 is connected to the focusing lens 503 and is used to transmit multi-mode optical signals. The multi-clad optical fiber 505 includes a core and at least two cladding structures surrounding the core. The imaging optical signal and the therapeutic optical signal can be transmitted simultaneously through the multi-clad optical fiber 505, and the imaging optical signal and the therapeutic optical signal do not interfere with each other during the transmission process. In this embodiment, the multi-clad optical fiber 505 can adopt a double-clad optical fiber; wherein the double-clad optical fiber includes a core, an inner cladding and an outer cladding sheath. Its core diameter is 9μm, which is used to transmit a single-mode optical signal of 1310nm; of course, if a single-mode optical signal of 840nm needs to be transmitted, its core diameter can be adjusted accordingly. Its inner cladding diameter is 105μm, which is used to transmit multi-mode optical signals of different wavelengths such as 405nm, 488nm, 532nm, and 630nm.
更具体而言，在上述内窥探头113还包括扭矩弹簧506和金属护套507的情况下，该多包层光纤505可以通过扭矩弹簧506连接至聚焦透镜503。该扭矩弹簧506为一不锈钢螺旋弹簧，其外部直径为1.8mm，和开有测向孔的金属护套507粘接在一起，用于传递来自光电连接器的扭矩，避免了内部的多包层光纤505受力造成损耗。More specifically, when the endoscopic probe 113 further includes a torque spring 506 and a metal sheath 507, the multi-clad optical fiber 505 can be connected to the focusing lens 503 through the torque spring 506. The torque spring 506 is a stainless steel coil spring with an outer diameter of 1.8 mm, which is bonded to the metal sheath 507 with a direction-finding hole, and is used to transmit torque from the optoelectronic connector, thereby avoiding loss of the internal multi-clad optical fiber 505 due to force.
在另一实施例中，上述内窥探头还可以包括透明外护套；在透明外护套包覆于内窥探头一端的情况下，在反射棱镜和超声换能器之间的间隙预充第二液体介质。其中，该第二液体介质可以采用油性液体介质；第二液体介质的选择应考虑其对超声信号的衰减、声阻抗以及与探头内部材料的兼容性等因素。需要补充说明的是，在本申请实施例中，可以根据实际应用情况选择是否为内窥探头适配透明保护套。如果配置有该透明外护套，则该透明外护套可以包裹在组装好的超声换能器和反射棱镜表面，以对其进行保护。同时，还可以向透明外护套内预充适量的第二液体介质，此时第二液体介质不会外漏，而是会填充在超声换能器和反射棱镜间隙。In another embodiment, the above-mentioned endoscopic probe may further include a transparent outer sheath; when the transparent outer sheath is coated on one end of the endoscopic probe, the gap between the reflective prism and the ultrasonic transducer is pre-filled with a second liquid medium. The second liquid medium may be an oily liquid medium; the selection of the second liquid medium should take into account factors such as its attenuation of ultrasonic signals, acoustic impedance, and compatibility with the internal materials of the probe. It should be noted that in the embodiment of the present application, it is possible to choose whether to adapt a transparent protective cover to the endoscopic probe according to the actual application. If the transparent outer sheath is configured, the transparent outer sheath can be wrapped around the assembled ultrasonic transducer and the reflective prism surface to protect them. At the same time, an appropriate amount of the second liquid medium can be pre-filled into the transparent outer sheath, and at this time the second liquid medium will not leak out, but will fill the gap between the ultrasonic transducer and the reflective prism.
作为示例，请参阅图7和图8。其中，图7为未设置透明外护套的内窥探头的结构示意图，此时超声换能器与反射棱镜连接，两者之间无液体充斥。图8为设置有透明外护套81的内窥探头的结构示意图，针对该内窥探头，反射棱镜501和超声换能器502间隙可预充第二液体介质82，用于声学信号的传递。As an example, please refer to Figures 7 and 8. Figure 7 is a schematic diagram of the structure of an endoscopic probe without a transparent outer sheath, in which the ultrasonic transducer is connected to the reflective prism, and there is no liquid between the two. Figure 8 is a schematic diagram of the structure of an endoscopic probe with a transparent outer sheath 81. For this endoscopic probe, the gap between the reflective prism 501 and the ultrasonic transducer 502 can be pre-filled with a second liquid medium 82 for the transmission of acoustic signals.
通过上述实施例，提供了多种不同结构的内窥探头设计方案，使得上述食管内窥诊疗系统能够适用于不同的应用场景，有效提高了系统应用的灵活性。Through the above embodiments, a variety of endoscopic probe design solutions with different structures are provided, so that the above esophageal endoscopic diagnosis and treatment system can be suitable for different application scenarios, effectively improving the flexibility of system application.
在其中一些实施例中，请参阅图5，上述多模态光学内窥装置还包括光电连接器508、光纤耦合器509和波分复用器510。In some of the embodiments, please refer to FIG. 5 , the multi-modal optical endoscopy device further includes a photoelectric connector 508 , a fiber optic coupler 509 and a wavelength division multiplexer 510 .
波分复用器510，分别连接多模态内窥光源、光动力治疗装置和光纤耦合器509。其中，波分复用器510用于不同波长的多模信号之间的耦合和分离。可选地，该波分复用器510可以采用1分4，或者1分2之后再各自1分2等形式。以图5为例，此时多模态内窥光源包括OCT光源511、光声光源512、荧光光源513和多模光纤光源514，且每个模态的光源对应一个第一图像处理模块。具体而言，波分复用器510的一端分别连接到各模态的光源以及光动力治疗装置中的光动力治疗光源，另一端连接到光纤耦合器，其中OCT光源511、光声光源512、荧光光源513、多模光纤光源514和光动力治疗光源515各自出射的成像光信号和治疗光信号，均经由波分复用器510进行复用和解复用操作，并传输至光纤耦合器509，使得各光源之间可以共用部分光路，简化了系统复杂性。The wavelength division multiplexer 510 is connected to the multi-modal endoscopic light source, the photodynamic therapy device and the fiber coupler 509 respectively. The wavelength division multiplexer 510 is used for coupling and separation between multi-mode signals of different wavelengths. Optionally, the wavelength division multiplexer 510 can be in the form of 1-to-4, or 1-to-2 and then 1-to-2 respectively. Taking Figure 5 as an example, at this time, the multi-modal endoscopic light source includes an OCT light source 511, a photoacoustic light source 512, a fluorescent light source 513 and a multi-mode fiber light source 514, and each modality of the light source corresponds to a first image processing module. Specifically, one end of the wavelength division multiplexer 510 is respectively connected to the light sources of each mode and the photodynamic therapy light source in the photodynamic therapy device, and the other end is connected to the fiber coupler, wherein the imaging light signals and treatment light signals emitted by the OCT light source 511, the photoacoustic light source 512, the fluorescent light source 513, the multimode fiber light source 514 and the photodynamic therapy light source 515 are multiplexed and demultiplexed through the wavelength division multiplexer 510 and transmitted to the fiber coupler 509, so that part of the optical path can be shared between the light sources, simplifying the complexity of the system.
光纤耦合器509，用于耦合多包层光纤505内传导的多模信号和单模信号。The optical fiber coupler 509 is used to couple the multi-mode signal and the single-mode signal transmitted in the multi-clad optical fiber 505 .
光电连接器508，分别连接光纤耦合器509和多包层光纤505，用于带动内窥探头113执行旋转和/或平移运动。在本实施例中，光电连接器508不仅负责传输光信号和电信号，还能在特定设计下支持内窥探头113的机械运动，如旋转和平移。具体而言，该光电连接器508可连接至外部电机，并受外部电机驱动。在实际应用过程中，光电连接器508在外部电机的驱动下，带动内窥探头113旋转或平移至指定位姿，以使内窥探头113可以在调整的指定位姿下工作。基于此，内窥探头113可以在人体食管内部进行螺旋式旋转以及回拉等操作，使得内窥探头113成像视场范围大且能够在体对病灶区域进行大规模的筛查，从而有利于扩展内窥探头113的工作空间，进一步提高了系统的灵活性。The photoelectric connector 508 is connected to the fiber coupler 509 and the multi-clad optical fiber 505, respectively, and is used to drive the endoscope probe 113 to perform rotation and/or translation movement. In this embodiment, the photoelectric connector 508 is not only responsible for transmitting optical signals and electrical signals, but also can support the mechanical movement of the endoscope probe 113, such as rotation and translation, under a specific design. Specifically, the photoelectric connector 508 can be connected to an external motor and driven by an external motor. In actual application, the photoelectric connector 508 drives the endoscope probe 113 to rotate or translate to a specified posture under the drive of an external motor, so that the endoscope probe 113 can work in the adjusted specified posture. Based on this, the endoscope probe 113 can perform spiral rotation and pullback operations inside the human esophagus, so that the imaging field of view of the endoscope probe 113 is large and can perform large-scale screening of the lesion area in the body, which is conducive to expanding the working space of the endoscope probe 113 and further improving the flexibility of the system.
此外，上述各光源对应的第一图像处理模块还连接至第一显示器516；则通过上述方式生成的第一成像图像，可以在第一显示器516上实时展示。In addition, the first image processing modules corresponding to the above-mentioned light sources are also connected to the first display 516 ; the first imaging image generated by the above-mentioned method can be displayed in real time on the first display 516 .
下面结合具体实施例进行说明。图9是根据本申请实施例的又一种食管内窥诊疗系统的结构框图，如图9所示，该系统包括：电子内窥装置21、多模态光学内窥装置11、适形光学平台搭建设备12和光动力治疗装置13。FIG9 is a structural block diagram of another esophageal endoscopic diagnosis and treatment system according to an embodiment of the present application. As shown in FIG9 , the system includes: an electronic endoscope device 21, a multimodal optical endoscope device 11, a conformal optical platform construction device 12 and a photodynamic therapy device 13.
电子内窥装置21包括电子内窥光源211、电子内窥镜体213、第二图像处理模块212和第二显示器91。该电子内窥镜体213集成有内径≥3.2mm的大钳道31，用于搭载适形光学平台系统，同时该电子内窥镜体213前端成像通道布置陷波滤光片，用于滤除光动力治疗光源515发出的630nm波长的激光。该电子内窥装置21用于获取肿瘤的跨尺度光学信息及光动力量效关系，实现全程可视化监测功能。其中，该电子内窥装置生成的成像数据可以通过第二显示器91进行实时展示。The electronic endoscope device 21 includes an electronic endoscope light source 211, an electronic endoscope body 213, a second image processing module 212, and a second display 91. The electronic endoscope body 213 is integrated with a large clamp channel 31 with an inner diameter ≥ 3.2 mm, which is used to carry a conformal optical platform system. At the same time, a notch filter is arranged in the front imaging channel of the electronic endoscope body 213 to filter out the 630nm wavelength laser emitted by the photodynamic therapy light source 515. The electronic endoscope device 21 is used to obtain the cross-scale optical information and photodynamic force efficiency relationship of the tumor, and realize the full-process visual monitoring function. Among them, the imaging data generated by the electronic endoscope device can be displayed in real time through the second display 91.
适形光学平台搭建设备12，包含透明支撑管道33、适配多模态内窥探头113的导管121及辅助充液机构32，该透明支撑管道33和导管121经电子内窥镜体213上集成的大钳道进入人体92的食管921这一目标部位，以实现在体建立适形光学平台；该适形光学平台搭建设备12主要用于解决食管不规则收缩蠕动、其他脏器搏动引起的环境扰动，为精细的光学诊疗提供稳定环境。The conformal optical platform construction device 12 comprises a transparent support pipe 33, a catheter 121 adapted to the multimodal endoscopic probe 113, and an auxiliary liquid filling mechanism 32. The transparent support pipe 33 and the catheter 121 enter the target part of the esophagus 921 of the human body 92 through the large forceps integrated on the electronic endoscope body 213 to achieve the establishment of a conformal optical platform in the body; the conformal optical platform construction device 12 is mainly used to solve the environmental disturbance caused by irregular contraction and peristalsis of the esophagus and pulsation of other organs, and provide a stable environment for precise optical diagnosis and treatment.
多模态光学内窥装置11，包括多模态内窥光源111、第一图像处理模块112、第一显示器516，以及集成了OCT、光声、荧光以及多模光纤超分辨成像模式的多模态内窥探头113。该内窥探头113经适形光学平台搭建设备12的导管121进入人体92食管921，进行在体多模态超分辨数据的获取与融合。其中，该多模态内窥光源111包含：OCT光源，其采用840nm/1310nm近红外光源；光声光源，其采用532nm激光光源；荧光光源，其采用405nm波长光源，多模光纤光源，其采用488nm激光光源。The multimodal optical endoscopy device 11 includes a multimodal endoscopy light source 111, a first image processing module 112, a first display 516, and a multimodal endoscopy probe 113 that integrates OCT, photoacoustic, fluorescence, and multimode fiber super-resolution imaging modes. The endoscopy probe 113 enters the esophagus 921 of the human body 92 through the catheter 121 of the conformal optical platform construction device 12 to acquire and fuse in vivo multimodal super-resolution data. Among them, the multimodal endoscopy light source 111 includes: an OCT light source, which uses an 840nm/1310nm near-infrared light source; a photoacoustic light source, which uses a 532nm laser light source; a fluorescence light source, which uses a 405nm wavelength light source, and a multimode fiber light source, which uses a 488nm laser light source.
光动力治疗装置13，包括用于发射治疗光信号的光动力治疗光源515，且该光动力治疗光源515连接到内窥探头113。该光动力治疗装置13用于肿瘤的靶向治疗，其利用波分复用器，进而通过光纤耦合器耦合进多模态内窥探头113内部的双包层光纤的纤芯中，在利用多模态光学内窥装置11进行精准诊断后，通过切换诊断光源和光动力光源即可完成诊断和治疗的切换，而无需拔出多模态内窥探头113，同时利用电子内窥装置21对治疗过程实时监测。其中，光动力治疗光源515采用630nm激光光源。The photodynamic therapy device 13 includes a photodynamic therapy light source 515 for emitting a therapeutic light signal, and the photodynamic therapy light source 515 is connected to the endoscopic probe 113. The photodynamic therapy device 13 is used for targeted treatment of tumors, and uses a wavelength division multiplexer, and then couples into the core of the double-clad optical fiber inside the multimodal endoscopic probe 113 through an optical fiber coupler. After accurate diagnosis is performed using the multimodal optical endoscopic device 11, the switching between diagnosis and treatment can be completed by switching the diagnostic light source and the photodynamic light source, without pulling out the multimodal endoscopic probe 113, and the electronic endoscopic device 21 is used to monitor the treatment process in real time. Among them, the photodynamic therapy light source 515 uses a 630nm laser light source.
通过上述实施例，提供了一种食管早癌在体超分辨精准诊疗的系统，该系统包括集成了大钳道的电子内窥装置21、适形光学平台搭建设备12、多模态光学内窥装置11以及光动力治疗装置13；其中电子内窥装置21用于获取肿瘤的跨尺度光学信息及光动力量效关系，以实现全程可视化监测功能；适形光学平台搭建设备12包括透明支撑管道33和适配多模态内窥探头113的导管121，用于解决食管921不规则收缩蠕动及脏器搏动引起的环境干扰，提供光学诊疗的稳定环境；多模态光学内窥装置11集成了OCT、光声、荧光以及多模光纤超分辨成像，用于获取病灶区域的组织形貌、组织分层、组织成分、细胞形态等多层次多维度信息，从而实现早癌的超分辨精准诊断；光动力治疗装置13用于肿瘤的靶向治疗。且各部件之间精确装配，设计巧妙。通过本申请，有效实现了食管早癌的在体超分辨精准诊断、治疗和监测。Through the above embodiments, a system for in vivo super-resolution and precise diagnosis and treatment of early esophageal cancer is provided, which includes an electronic endoscope device 21 integrated with a large channel, a conformal optical platform construction device 12, a multi-modal optical endoscope device 11, and a photodynamic therapy device 13; wherein the electronic endoscope device 21 is used to obtain the cross-scale optical information and photodynamic force efficiency relationship of the tumor to realize the full-process visual monitoring function; the conformal optical platform construction device 12 includes a transparent support pipe 33 and a catheter 121 adapted to the multi-modal endoscope probe 113, which is used to solve the environmental interference caused by the irregular contraction and peristalsis of the esophagus 921 and the pulsation of the organs, and provide a stable environment for optical diagnosis and treatment; the multi-modal optical endoscope device 11 integrates OCT, photoacoustic, fluorescence, and multi-mode optical fiber super-resolution imaging, which is used to obtain multi-level and multi-dimensional information such as tissue morphology, tissue stratification, tissue composition, and cell morphology of the lesion area, thereby realizing super-resolution and precise diagnosis of early cancer; the photodynamic therapy device 13 is used for targeted treatment of tumors. And the components are precisely assembled and the design is ingenious. Through this application, in vivo super-resolution precise diagnosis, treatment and monitoring of early esophageal cancer are effectively achieved.
本实施例还提供了一种电子装置，包括存储器和处理器，该存储器中存储有计算机程序，该处理器被设置为运行计算机程序以执行上述任一食管内窥诊疗系统的工作。This embodiment also provides an electronic device, including a memory and a processor, wherein the memory stores a computer program, and the processor is configured to run the computer program to perform the work of any of the above-mentioned esophageal endoscopic diagnosis and treatment systems.
可选地，上述电子装置还可以包括传输设备以及输入输出设备，其中，该传输设备和上述处理器连接，该输入输出设备和上述处理器连接。Optionally, the electronic device may further include a transmission device and an input/output device, wherein the transmission device is connected to the processor, and the input/output device is connected to the processor.
需要说明的是，本实施例中的具体示例可以参考上述实施例及可选实施方式中所描述的示例，本实施例在此不再赘述。It should be noted that the specific examples in this embodiment can refer to the examples described in the above embodiments and optional implementation modes, and this embodiment will not be described in detail here.
另外，结合上述实施例中的食管内窥诊疗系统，本申请实施例可提供一种存储介质来实现。该存储介质上存储有计算机程序；该计算机程序被处理器执行时实现上述实施例中的任意一种食管内窥诊疗系统的工作。In addition, in combination with the esophageal endoscope diagnosis and treatment system in the above embodiments, the present application embodiment can provide a storage medium to implement. The storage medium stores a computer program; when the computer program is executed by the processor, the operation of any one of the esophageal endoscope diagnosis and treatment systems in the above embodiments is implemented.
本领域的技术人员应该明白，以上所述实施例的各技术特征可以进行任意的组合，为使描述简洁，未对上述实施例中的各个技术特征所有可能的组合都进行描述，然而，只要这些技术特征的组合不存在矛盾，都应当认为是本说明书记载的范围。Those skilled in the art should understand that the technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.
以上所述实施例仅表达了本申请的几种实施方式，其描述较为具体和详细，但并不能因此而理解为对发明专利范围的限制。应当指出的是，对于本领域的普通技术人员来说，在不脱离本申请构思的前提下，还可以做出若干变形和改进，这些都属于本申请的保护范围。因此，本申请专利的保护范围应以所附权利要求为准。The above-mentioned embodiments only express several implementation methods of the present application, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the invention patent. It should be pointed out that, for a person of ordinary skill in the art, several variations and improvements can be made without departing from the concept of the present application, and these all belong to the protection scope of the present application. Therefore, the protection scope of the patent of the present application shall be subject to the attached claims.
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202411171816.0ACN118680505B (en) | 2024-08-26 | 2024-08-26 | Esophageal endoscopy diagnosis and treatment system and storage medium |
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202411171816.0ACN118680505B (en) | 2024-08-26 | 2024-08-26 | Esophageal endoscopy diagnosis and treatment system and storage medium |
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| CN118680505Atrue CN118680505A (en) | 2024-09-24 |
| CN118680505B CN118680505B (en) | 2025-01-28 |
| Application Number | Title | Priority Date | Filing Date |
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| CN202411171816.0AActiveCN118680505B (en) | 2024-08-26 | 2024-08-26 | Esophageal endoscopy diagnosis and treatment system and storage medium |
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