技术领域Technical Field
本申请涉及医疗器械智慧医疗领域，尤其涉及一种基于一体化单针的复合物理场自适应消融系统和装置。The present application relates to the field of smart medical treatment using medical devices, and in particular to a composite physical field adaptive ablation system and device based on an integrated single needle.
背景技术Background Art
肿瘤，尤其是恶性肿瘤是危害人类健康的重要疾病。近年来，我国和世界范围内的肿瘤新发病例和死亡病例均持续攀升，其高发趋势凸显了发展肿瘤微创治疗创新技术的必要性和紧迫性。传统消融术治疗不彻底、术后易复发，是限制消融术式推广的一大因素。脉冲电场是一种近年来新兴的肿瘤微创消融治疗手段，其通过对肿瘤靶组织施加局部短脉冲高电压，在细胞膜和/或内部细胞器膜上形成永久性穿孔，改变细胞通透性和电学特性，从而导致细胞凋亡。相比传统的以温差为基础的微波、射频、冷冻等冷热消融技术对肿瘤、神经血管等组织无差别杀伤，脉冲电场具有较高的组织器官特异性消融或选择性消融的特性，具有更高的消融治疗精准性、安全性和有效性。Tumors, especially malignant tumors, are important diseases that endanger human health. In recent years, the number of new cases and deaths of tumors in my country and around the world has continued to rise. The high incidence trend highlights the necessity and urgency of developing innovative technologies for minimally invasive tumor treatment. The incomplete treatment of traditional ablation and the easy recurrence after surgery are major factors limiting the promotion of ablation procedures. Pulsed electric field is an emerging minimally invasive tumor ablation treatment method in recent years. It applies local short pulse high voltage to the tumor target tissue to form permanent perforations on the cell membrane and/or internal organelle membrane, change cell permeability and electrical properties, and thus lead to cell apoptosis. Compared with traditional temperature-based microwave, radiofrequency, freezing and other cold and hot ablation technologies that indiscriminately kill tumors, nerves and blood vessels and other tissues, pulsed electric fields have the characteristics of higher tissue and organ specific ablation or selective ablation, and have higher ablation treatment accuracy, safety and effectiveness.
然而另一方面，脉冲电场肿瘤消融治疗技术也面临不足。首先，双针平行操作难度大的问题。当前，脉冲电场肿瘤消融治疗时，需要一根正极一根负极两根电极针之间放电产生高压电场形成消融治疗区域，插入的两根电极需要尽可能保证相互平行，才能达到最佳治疗范围和效果，这对临床医师的实际操作经验/水平要求高、难度大，实际操作过程中很难保证两根电极相互平行，影响脉冲电场实际消融效果。其次，针道出血及肿瘤种植扩散风险。脉冲电场的非热消融特性，虽然提高了消融的精度、有效性和安全性，但是其不具备传统热消融的凝血/止血功能，在消融治疗手术过程中存在病人出血风险、面临凝血难题；此外，脉冲电场消融时可能会有病灶活细胞残留消融针，退针时在针道区域造成癌细胞扩散种植风险也不能完全忽视。On the other hand, however, pulsed electric field tumor ablation treatment technology also faces shortcomings. First, the problem of difficulty in parallel operation of two needles. At present, during pulsed electric field tumor ablation treatment, a high-voltage electric field is generated between two electrode needles, one positive and one negative, to form an ablation treatment area. The two inserted electrodes need to be as parallel as possible to achieve the best treatment range and effect. This requires high practical operation experience/level of clinical physicians and is difficult. It is difficult to ensure that the two electrodes are parallel to each other during actual operation, which affects the actual ablation effect of pulsed electric field. Secondly, the risk of needle tract bleeding and tumor implantation and spread. Although the non-thermal ablation characteristics of pulsed electric fields improve the accuracy, effectiveness and safety of ablation, they do not have the coagulation/hemostasis function of traditional thermal ablation. There is a risk of bleeding in patients and coagulation problems during ablation surgery; in addition, there may be residual live cells in the ablation needle during pulsed electric field ablation, and the risk of cancer cell spread and implantation in the needle tract area when the needle is withdrawn cannot be completely ignored.
发明内容Summary of the invention
有鉴于此，本申请提供一种基于一体化单针的复合物理场自适应消融系统和装置，通过一体化单根电极针，自适应发射多种物理场能量，同时解决平行针操作难题和止血/种植风险问题。In view of this, the present application provides a composite physical field adaptive ablation system and device based on an integrated single needle, which adaptively emits multiple physical field energies through an integrated single electrode needle, while solving the parallel needle operation difficulties and hemostasis/implantation risk problems.
本申请第一方面提供一种基于一体化单针的复合物理场自适应消融系统，所述系统包括一体化单针模块，复合物理场能量发生模块，自适应调控模块和消融参数确定模块；The first aspect of the present application provides a composite physical field adaptive ablation system based on an integrated single needle, the system comprising an integrated single needle module, a composite physical field energy generation module, an adaptive control module and an ablation parameter determination module;
所述一体化单针模块包含一体化电极针，所述一体化电极针包含若干个不同类型的电极组，用于将所述复合物理场能量发生模块生成的不同的能量发射至目标消融区域，实现复合物理场的精准消融；The integrated single needle module includes an integrated electrode needle, and the integrated electrode needle includes a plurality of electrode groups of different types, which are used to transmit different energies generated by the composite physical field energy generation module to the target ablation area, so as to achieve precise ablation of the composite physical field;
所述复合物理场能量发生模块用于通过消融治疗时序函数确定目标消融方法，并根据所述目标消融方法确定目标能量类型，根据所述目标能量类型对应的消融参数生成能量，并通过一体化电极针对所述目标消融区域发射所述能量进行消融治疗；The composite physical field energy generation module is used to determine the target ablation method through the ablation treatment timing function, and determine the target energy type according to the target ablation method, generate energy according to the ablation parameters corresponding to the target energy type, and transmit the energy to the target ablation area through the integrated electrode for ablation treatment;
所述自适应调控模块用于通过实时影像对所述目标消融区域进行监控，并根据监控结果调整所述消融治疗时序函数；The adaptive control module is used to monitor the target ablation area through real-time images and adjust the ablation treatment timing function according to the monitoring results;
所述消融参数确定模块用于通过目标患者的术前信息和术中影像确定所述目标消融方法的消融参数，并将所述消融参数发送给复合物理场能量发生模块，使所述复合物理场能量发生模块依据所述消融参数生成能量。The ablation parameter determination module is used to determine the ablation parameters of the target ablation method through the preoperative information and intraoperative images of the target patient, and send the ablation parameters to the composite physical field energy generation module so that the composite physical field energy generation module generates energy according to the ablation parameters.
可选的，所述不同类型的电极组包括射频电极组和脉冲电场电极组；Optionally, the different types of electrode groups include radio frequency electrode groups and pulsed electric field electrode groups;
所述通过消融治疗时序函数确定目标消融方法包括：The method for determining a target ablation through an ablation treatment timing function includes:
根据电极组的类型确定所述消融治疗时序函数包含射频消融时序函数和脉冲电场消融时序函数，确定所述射频消融时序函数为，所述脉冲电场消融时序函数为；According to the type of electrode group, the ablation treatment timing function includes a radiofrequency ablation timing function and a pulsed electric field ablation timing function, and the radiofrequency ablation timing function is determined to be , the pulse electric field ablation timing function is ;
确定所述和的值，当所述时，通过所述射频电极组发射能量，当所述，通过所述脉冲电场电极组发射能量。Determine the and When the value of When the radio frequency electrode group transmits energy, , emitting energy through the pulsed electric field electrode group.
可选的，所述复合物理场能量发生模块包括电源模块，控制模块，若干个不同的能量驱动模块，若干个不同的能量产生模块，输出切换模块以及能量输出接口；Optionally, the composite physical field energy generation module includes a power supply module, a control module, a plurality of different energy driving modules, a plurality of different energy generation modules, an output switching module and an energy output interface;
所述电源模块包含AC-DC转换模块，DC-DC转换模块，用于进行电源转换并为其他模块提供所需的电源；The power supply module includes an AC-DC conversion module and a DC-DC conversion module, which are used to perform power conversion and provide the required power for other modules;
所述控制模块用于为所述能量驱动模块提供所需的驱动信号，从而产生所述能量产生模块所需的驱动信号，并为不同的能量产生模块之间提供相应的交互信息、采集反馈信号发送给所述自适应调控模块；The control module is used to provide the required driving signal for the energy driving module, thereby generating the driving signal required by the energy generating module, and providing corresponding interaction information between different energy generating modules, collecting feedback signals and sending them to the adaptive control module;
所述输出切换模块和能量输出接口根据所述消融时序函数切换能量并进行输出。The output switching module and the energy output interface switch the energy and output it according to the ablation timing function.
可选的，所述系统还包括影像导航功能模块；Optionally, the system further includes an image navigation function module;
所述影像导航功能模块用于通过实时影像在执行进退针操作时对所述一体化电极针的周围区域进行实时监控，根据所述实时影像调整进退针路径并根据调整后的进退针路径进行导航。The image navigation function module is used to monitor the surrounding area of the integrated electrode needle in real time when performing needle advancement and withdrawal operations through real-time images, adjust the needle advancement and withdrawal path according to the real-time images, and navigate according to the adjusted needle advancement and withdrawal path.
可选的，所述系统还包括模拟仿真模块；Optionally, the system further includes a simulation module;
所述模拟仿真模块用于所述复合物理场能量发生模块依据所述消融参数生成能量之前，根据所述消融参数进行消融模拟仿真，并根据所述消融模拟仿真生成的模拟消融区域确定是否符合预期；The simulation module is used for performing ablation simulation according to the ablation parameters before the composite physical field energy generation module generates energy according to the ablation parameters, and determining whether the simulated ablation area generated by the ablation simulation meets expectations;
当符合时，通知所述复合物理场能量发生模块依据所述消融参数发送能量；When the conditions are met, informing the composite physical field energy generation module to send energy according to the ablation parameters;
当不符合时，调整所述消融参数，并根据调整后的消融参数再次进行消融模拟仿真，直至所述模拟消融区域符合预期时，通过所述复合物理场能量发生模块依据调整后的消融参数发送能量。When it does not meet the requirements, the ablation parameters are adjusted, and ablation simulation is performed again according to the adjusted ablation parameters, until the simulated ablation area meets expectations, and energy is sent according to the adjusted ablation parameters through the composite physical field energy generation module.
本申请第二方面提供一种基于一体化单针的复合物理场自适应消融装置，所述装置包括：The second aspect of the present application provides a composite physical field adaptive ablation device based on an integrated single needle, the device comprising:
消融参数确定单元，用于通过目标患者的术前信息和术中影像确定进行消融治疗的消融参数；an ablation parameter determination unit, used to determine ablation parameters for ablation treatment based on preoperative information and intraoperative images of a target patient;
自适应调控单元，用于通过实时影像对目标消融区域进行监控，并根据监控结果调整所述消融治疗时序函数；An adaptive control unit, used to monitor the target ablation area through real-time images and adjust the ablation treatment timing function according to the monitoring results;
复合物理场能量发生单元，用于通过所述消融治疗时序函数确定目标消融方法，根据所述目标消融方法确定目标能量类型，根据所述目标能量类型对应的消融参数生成能量，并通过一体化电极针对所述目标消融区域发射所述能量进行消融治疗，其中，所述一体化电极针包含若干个不同类型的电极组。A composite physical field energy generating unit is used to determine a target ablation method through the ablation treatment timing function, determine a target energy type according to the target ablation method, generate energy according to ablation parameters corresponding to the target energy type, and transmit the energy to the target ablation area through an integrated electrode for ablation treatment, wherein the integrated electrode needle includes several electrode groups of different types.
可选的，所述复合物理场能量发生单元中的不同类型的电极组包括射频电极组和脉冲电场电极组；Optionally, the different types of electrode groups in the composite physical field energy generating unit include a radio frequency electrode group and a pulsed electric field electrode group;
所述通过消融治疗时序函数确定目标消融方法包括：The method for determining a target ablation through an ablation treatment timing function includes:
根据电极组的类型确定所述消融治疗时序函数包含射频消融时序函数和脉冲电场消融时序函数，确定所述射频消融时序函数为，所述脉冲电场消融时序函数为；According to the type of electrode group, the ablation treatment timing function includes a radiofrequency ablation timing function and a pulsed electric field ablation timing function, and the radiofrequency ablation timing function is determined to be , the pulse electric field ablation timing function is ;
确定所述和的值，当所述时，通过所述射频电极组发射能量，当所述，通过所述脉冲电场电极组发射能量。Determine the and When the value of When the radio frequency electrode group transmits energy, , emitting energy through the pulsed electric field electrode group.
可选的，所述复合物理场能量发生单元包括电源模块，控制模块，若干个不同的能量驱动模块，若干个不同的能量产生模块，输出切换模块以及能量输出接口；Optionally, the composite physical field energy generation unit includes a power supply module, a control module, a plurality of different energy driving modules, a plurality of different energy generation modules, an output switching module and an energy output interface;
所述电源模块包含AC-DC转换模块，DC-DC转换模块，用于进行电源转换并为其他模块提供所需的电源；The power supply module includes an AC-DC conversion module and a DC-DC conversion module, which are used to perform power conversion and provide the required power for other modules;
所述控制模块用于为所述能量驱动模块提供所需的驱动信号，从而产生所述能量产生模块所需的驱动信号，并为不同的能量产生模块之间提供相应的交互信息、采集反馈信号发送给所述自适应调控模块；The control module is used to provide the required driving signal for the energy driving module, thereby generating the driving signal required by the energy generating module, and providing corresponding interaction information between different energy generating modules, collecting feedback signals and sending them to the adaptive control module;
所述输出切换模块和能量输出接口根据所述消融时序函数切换能量并进行输出。The output switching module and the energy output interface switch the energy and output it according to the ablation timing function.
可选的，所述装置还包括：Optionally, the device further comprises:
影像导航功能单元，用于通过实时影像在执行进退针操作时对所述一体化电极针的周围区域进行实时监控，根据所述实时影像调整进退针路径并根据调整后的进退针路径进行导航。The image navigation function unit is used to monitor the surrounding area of the integrated electrode needle in real time through real-time images when performing needle advancement and withdrawal operations, adjust the needle advancement and withdrawal path according to the real-time images, and navigate according to the adjusted needle advancement and withdrawal path.
可选的，所述装置还包括：Optionally, the device further comprises:
模拟仿真单元，用于根据所述目标能量类型对应的消融参数生成能量之前，根据所述消融参数进行消融模拟仿真，并根据所述消融模拟仿真生成的模拟消融区域确定是否符合预期；A simulation unit, configured to perform ablation simulation according to the ablation parameters before generating energy according to the ablation parameters corresponding to the target energy type, and determine whether the simulated ablation area generated by the ablation simulation meets expectations;
当符合时，通知所述复合物理场能量发生模块依据所述消融参数发送能量；When the conditions are met, informing the composite physical field energy generation module to send energy according to the ablation parameters;
当不符合时，调整所述消融参数，并根据调整后的消融参数再次进行消融模拟仿真，直至所述模拟消融区域符合预期时，通过所述复合物理场能量发生模块依据调整后的消融参数发送能量。When it does not meet the requirements, the ablation parameters are adjusted, and ablation simulation is performed again according to the adjusted ablation parameters, until the simulated ablation area meets expectations, and energy is sent according to the adjusted ablation parameters through the composite physical field energy generation module.
在本申请提供的实施例中，系统集成了多种能量发生设备，并通过消融治疗时序函数对其进行控制，一体化电极针则包含了用于各个能量发生设备对应的电极组。在消融手术过程中，通过预设的消融方法对消融区域进行治疗并对该消融区域进行监控，当确定需要调整消融方法时，则自适应的通过消融治疗时序函数进行调整，使得调整后的能量发生设备生成能量并通过一体化电极针上该能量对应的电极组发射。这实现了在消融手术过程中，通过一体化单根电极针自适应发射多种物理场能量，解决了消融治疗手术中的平行针操作难题和止血/种植风险问题。In the embodiment provided in the present application, the system integrates a variety of energy generating devices and controls them through ablation treatment timing functions, and the integrated electrode needle includes electrode groups corresponding to each energy generating device. During the ablation procedure, the ablation area is treated and monitored by a preset ablation method. When it is determined that the ablation method needs to be adjusted, the ablation treatment timing function is adaptively adjusted so that the adjusted energy generating device generates energy and emits it through the electrode group corresponding to the energy on the integrated electrode needle. This realizes the adaptive emission of multiple physical field energies through an integrated single electrode needle during the ablation procedure, solving the parallel needle operation problem and hemostasis/implantation risk problems in ablation treatment surgery.
附图说明BRIEF DESCRIPTION OF THE DRAWINGS
图1为本申请实施例提供的系统模块图；FIG1 is a system module diagram provided in an embodiment of the present application;
图2为本申请实施例提供的一体化单针的结构示意图；FIG2 is a schematic diagram of the structure of an integrated single needle provided in an embodiment of the present application;
图3为本申请实施例提供的复合物理场能量发生模块的结构示意图FIG. 3 is a schematic diagram of the structure of a composite physical field energy generation module provided in an embodiment of the present application.
图4为本申请实施例提供的自适应消融方法的时序调控示意图；FIG4 is a schematic diagram of timing control of an adaptive ablation method provided in an embodiment of the present application;
图5为本申请实施例提供的自适应消融方法的另一个时序调控示意图；FIG5 is another timing control schematic diagram of the adaptive ablation method provided in an embodiment of the present application;
图6为本申请实施例提供的装置结构图；FIG6 is a structural diagram of a device provided in an embodiment of the present application;
图7为本申请实施例提供的计算机设备内部结构示意图。FIG. 7 is a schematic diagram of the internal structure of a computer device provided in an embodiment of the present application.
具体实施方式DETAILED DESCRIPTION
这里将详细地对示例性实施例进行说明，其示例表示在附图中。下面的描述涉及附图时，除非另有表示，不同附图中的相同数字表示相同或相似的要素。以下示例性实施例中所描述的实施方式并不代表与本申请相一致的所有实施方式。相反，它们仅是与如所附权利要求书中所详述的、本申请的一些方面相一致的装置和方法的例子。Exemplary embodiments will be described in detail herein, examples of which are shown in the accompanying drawings. When the following description refers to the drawings, unless otherwise indicated, the same numbers in different drawings represent the same or similar elements. The implementations described in the following exemplary embodiments do not represent all implementations consistent with the present application. Instead, they are merely examples of devices and methods consistent with some aspects of the present application as detailed in the appended claims.
在本申请使用的术语是仅仅出于描述特定实施例的目的，而非旨在限制本申请。在本申请和所附权利要求书中所使用的单数形式的“一种”、“所述”和“该”也旨在包括多数形式，除非上下文清楚地表示其他含义。还应当理解，本文中使用的术语“和/或”是指并包含一个或多个相关联的列出项目的任何或所有可能组合。The terms used in this application are for the purpose of describing specific embodiments only and are not intended to limit this application. The singular forms of "a", "said" and "the" used in this application and the appended claims are also intended to include plural forms unless the context clearly indicates other meanings. It should also be understood that the term "and/or" used herein refers to and includes any or all possible combinations of one or more associated listed items.
应当理解，尽管在本申请可能采用术语第一、第二、第三等来描述各种信息，但这些信息不应限于这些术语。这些术语仅用来将同一类型的信息彼此区分开。例如，在不脱离本申请范围的情况下，第一信息也可以被称为第二信息，类似地，第二信息也可以被称为第一信息。取决于语境，如在此所使用的词语“如果”可以被解释成为“在……时”或“当……时”或“响应于确定”。It should be understood that although the terms first, second, third, etc. may be used in the present application to describe various information, these information should not be limited to these terms. These terms are only used to distinguish the same type of information from each other. For example, without departing from the scope of the present application, the first information may also be referred to as the second information, and similarly, the second information may also be referred to as the first information. Depending on the context, the word "if" as used herein may be interpreted as "at the time of" or "when" or "in response to determining".
本申请提供一种基于一体化单针的复合物理场自适应消融系统，以解决消融治疗手术过程中的平行针操作难题和止血/种植风险的问题。The present application provides a composite physical field adaptive ablation system based on an integrated single needle to solve the problem of parallel needle operation and hemostasis/implantation risk during ablation treatment surgery.
下面以具体的实施例对本申请的技术方案进行详细说明。这几个具体的实施例可以相互结合，对于相同或相似的概念或过程可能在某些实施例不再赘述。The technical solution of the present application is described in detail with specific embodiments below. These specific embodiments can be combined with each other, and the same or similar concepts or processes may not be described in detail in some embodiments.
如图1所示，为本申请提供的一种基于一体化单针的复合物理场自适应消融系统的模块图，该系统包括一体化单针模块，复合物理场能量发生模块，自适应调控模块和消融参数确定模块。As shown in FIG1 , it is a module diagram of a composite physical field adaptive ablation system based on an integrated single needle provided in the present application. The system includes an integrated single needle module, a composite physical field energy generation module, an adaptive control module and an ablation parameter determination module.
下面对各个模块的功能进行说明：The functions of each module are described below:
1、一体化单针模块。该模块包含一体化电极针，该一体化电极针包含若干个不同类型的电极组，用于将所述复合物理场能量发生模块生成的不同的能量发射至目标消融区域，实现复合物理场的精准消融。1. Integrated single needle module. This module includes an integrated electrode needle, which includes several different types of electrode groups, and is used to transmit different energies generated by the composite physical field energy generation module to the target ablation area to achieve precise ablation of the composite physical field.
示例性的，如图2所示，该电极针包含4个电极，通过连接线与自适应控制模块连接。其中电极1和3可以组成一对射频电极组，电极2和4可以组成一对脉冲电场电极组，并且电极上还可以加装温度传感器或压力传感器，以及微波等其他热消融能量形式。通过该电极针可以实现将射频消融能量或脉冲电场消融能量发射到目标区域。从而通过单个电极针实现热场-脉冲电场的复核消融。Exemplarily, as shown in FIG2 , the electrode needle includes 4 electrodes, which are connected to the adaptive control module through a connecting line. Electrodes 1 and 3 can form a pair of radio frequency electrode groups, electrodes 2 and 4 can form a pair of pulsed electric field electrode groups, and temperature sensors or pressure sensors, as well as other thermal ablation energy forms such as microwaves, can also be installed on the electrodes. The electrode needle can be used to transmit radio frequency ablation energy or pulsed electric field ablation energy to the target area. Thus, thermal field-pulsed electric field double-check ablation is achieved through a single electrode needle.
2、复合物理场能量发生模块。该模块用于通过消融治疗时序函数确定目标消融方法，并根据所述目标消融方法确定目标能量类型，根据所述目标能量类型对应的消融参数生成能量，并通过一体化电极针对所述目标消融区域发射所述能量进行消融治疗。2. Composite physical field energy generation module. This module is used to determine the target ablation method through the ablation treatment timing function, determine the target energy type according to the target ablation method, generate energy according to the ablation parameters corresponding to the target energy type, and transmit the energy to the target ablation area through the integrated electrode for ablation treatment.
在本模块中，可以为本方案中集成的各个能量发生设备设定一个消融治疗时序函数，并为各个能量发生设备设置不同的函数值。例如，当消融治疗时序函数值为1时，通过能量发生设备A生成能量，再通过一体化电极针该能量对应的电极组发射到目标区域。当消融治疗时序函数值为2时，通过能量发生设备B生成能量；当消融治疗时序函数值为3时，通过能量发生设备C生成能量。In this module, an ablation therapy timing function can be set for each energy generating device integrated in this solution, and different function values can be set for each energy generating device. For example, when the ablation therapy timing function value is 1, energy is generated by energy generating device A, and then the electrode group corresponding to the energy is emitted to the target area through the integrated electrode needle. When the ablation therapy timing function value is 2, energy is generated by energy generating device B; when the ablation therapy timing function value is 3, energy is generated by energy generating device C.
在另一个实施例中，可以为不同的能量发生设备设定不同的消融治疗时序函数，通过各个消融治疗时序函数控制对应的能量发生设备开启或关闭。例如，当本系统集成了射频能量发生设备以及脉冲电场能量发生设备，则在一体化电极针上配置射频电极组以及脉冲电场电极组。根据电极组的类型确定所述消融治疗时序函数包含射频消融时序函数和脉冲电场消融时序函数，确定射频消融时序函数为，用于控制射频能量发生设备。脉冲电场消融时序函数为，用于控制脉冲电场能量发生设备。在消融治疗过程中，实时检测和的值，当时，控制射频能量发生设备开启，通过电极针上的射频电极组发射能量，当，则控制脉冲电场能量发生设备开启，通过该电极针上的脉冲电场电极组发射能量。这使得在消融治疗手术过程中，通过控制和的值，即可实现消融方法的切换。In another embodiment, different ablation therapy timing functions can be set for different energy generating devices, and the corresponding energy generating devices can be turned on or off by each ablation therapy timing function. For example, when the system integrates a radio frequency energy generating device and a pulsed electric field energy generating device, a radio frequency electrode group and a pulsed electric field electrode group are configured on the integrated electrode needle. According to the type of electrode group, it is determined that the ablation therapy timing function includes a radio frequency ablation timing function and a pulsed electric field ablation timing function, and the radio frequency ablation timing function is determined to be , used to control the RF energy generating device. The pulse electric field ablation timing function is , used to control the pulse electric field energy generating device. During ablation therapy, real-time detection and When When the radio frequency energy generating device is turned on, the radio frequency electrode group on the electrode needle transmits energy. , then the pulse electric field energy generating device is controlled to start, and the pulse electric field electrode group on the electrode needle emits energy. This makes it possible to control the ablation treatment process. and The value of can be used to switch the ablation method.
在另一个实施例中，所述复合物理场能量发生模块包括电源模块，控制模块，若干个不同的能量驱动模块，若干个不同的能量产生模块，输出切换模块以及能量输出接口；In another embodiment, the composite physical field energy generation module includes a power supply module, a control module, a plurality of different energy driving modules, a plurality of different energy generation modules, an output switching module and an energy output interface;
所述电源模块包含AC-DC转换模块，DC-DC转换模块，用于进行电源转换并为其他模块提供所需的电源；The power supply module includes an AC-DC conversion module and a DC-DC conversion module, which are used to perform power conversion and provide the required power for other modules;
所述控制模块用于为所述能量驱动模块提供所需的驱动信号，从而产生所述能量产生模块所需的驱动信号，并为不同的能量产生模块之间提供相应的交互信息、采集反馈信号发送给所述自适应调控模块；The control module is used to provide the required driving signal for the energy driving module, thereby generating the driving signal required by the energy generating module, and providing corresponding interaction information between different energy generating modules, collecting feedback signals and sending them to the adaptive control module;
所述输出切换模块和能量输出接口根据所述消融时序函数切换能量并进行输出。The output switching module and the energy output interface switch the energy and output it according to the ablation timing function.
在本实施例中，以脉冲电场和射频能量复合消融为例，该复合物理场能量发生模块结构示意图如图3所示。电源模块提供控制模块、射频驱动模块、脉冲驱动模块以及射频能量模块、脉冲能量模块所需电源。控制模块为射频驱动模块和脉冲驱动模块提供所需的驱动信号，从而产生两个能量模块所需的驱动信号，同时为射频能量模块和脉冲能量模块提供相应的交互信息、采集反馈信号发送给自适应调控模块并从自适应调控模块获取指令信息，达到理想的能力输出状态。输出切换模块和能量输出端口根据消融时序函数实时调整输出模式，满足靶点消融能量的需要。In this embodiment, taking the combined ablation of pulsed electric field and radio frequency energy as an example, the schematic diagram of the structure of the composite physical field energy generation module is shown in Figure 3. The power supply module provides the power required by the control module, radio frequency drive module, pulse drive module, radio frequency energy module, and pulse energy module. The control module provides the required driving signals for the radio frequency drive module and the pulse drive module, thereby generating the driving signals required by the two energy modules, and at the same time provides the radio frequency energy module and the pulse energy module with corresponding interactive information, collects feedback signals and sends them to the adaptive control module, and obtains instruction information from the adaptive control module to achieve the ideal capacity output state. The output switching module and the energy output port adjust the output mode in real time according to the ablation timing function to meet the needs of the target ablation energy.
3、自适应调控模块。该模块用于通过实时影像对所述目标消融区域进行监控，并根据监控结果调整所述消融治疗时序函数。3. Adaptive control module: This module is used to monitor the target ablation area through real-time images and adjust the ablation treatment timing function according to the monitoring results.
在本实施例中，可以针对不同的场景调整消融治疗时序函数，从而实现消融方法的切换。In this embodiment, the ablation treatment timing function can be adjusted according to different scenarios, thereby achieving switching of ablation methods.
场景1，脉冲电场消融结束后对针道进行热消融以避免癌细胞扩散种植。Scenario 1: After pulsed electric field ablation, thermal ablation is performed on the needle track to prevent the spread of cancer cells.
步骤一，自适应调控模块保持射频能量发生设备关闭，即。保持射频电极组断开状态。开启脉冲电场能量发生设备，即，并连接脉冲电场电极组。Step 1: The adaptive control module keeps the RF energy generating device turned off. Keep the RF electrode group disconnected. Turn on the pulsed electric field energy generator. , and connect the pulsed electric field electrode group.
步骤二，对目标消融区域进行脉冲电场消融，直至脉冲电场消融结束。Step 2: Perform pulsed electric field ablation on the target ablation area until the pulsed electric field ablation is completed.
步骤三，自适应调控模块关闭脉冲电场能量发生设备，即，断开脉冲电场电极组。开启射频能量发生设备，即，并连接射频电极组。Step 3: The adaptive control module turns off the pulse electric field energy generating device. , disconnect the pulsed electric field electrode group. Turn on the RF energy generating device, that is, , and connect the radio frequency electrode group.
步骤四，对针道进行热消融，直到消融结束，时序调控示意图如图4所示。Step 4: thermally ablate the needle track until the ablation is completed. The schematic diagram of timing control is shown in FIG4 .
在本场景中，通过脉冲电-热复合场，实现对靶区脉冲电场消融治疗后，还对针道进行的热消融，从而避免了癌细胞扩散种植。In this scenario, after pulsed electric field ablation treatment of the target area, thermal ablation of the needle track is performed through a pulsed electric-thermal composite field, thus avoiding the spread and implantation of cancer cells.
场景2，脉冲电场消融过程中突发严重出血而进行紧急止血。Scenario 2: Severe bleeding occurs suddenly during pulsed electric field ablation and emergency hemostasis is performed.
步骤一，自适应调控模块保持射频能量发生设备关闭，即。保持射频电极组断开状态。开启脉冲电场能量发生设备，即，并连接脉冲电场电极组。Step 1: The adaptive control module keeps the RF energy generating device turned off. Keep the RF electrode group disconnected. Turn on the pulsed electric field energy generator. , and connect the pulsed electric field electrode group.
步骤二，对目标消融组织进行脉冲电场消融，并在消融过程进行实时影像监控，如发现突发出血，则进入步骤三；若无出血情况，持续对目标消融组织进行脉冲电场消融，直到消融结束。Step 2: Perform pulsed electric field ablation on the target ablation tissue and conduct real-time image monitoring during the ablation process. If sudden bleeding is found, proceed to step 3; if there is no bleeding, continue to perform pulsed electric field ablation on the target ablation tissue until the ablation is completed.
步骤三，自适应调控模块关闭脉冲电场能量发生设备，即，断开脉冲电场电极组。开启射频能量发生设备，即，并连接射频电极组。Step 3: The adaptive control module turns off the pulse electric field energy generating device. , disconnect the pulsed electric field electrode group. Turn on the RF energy generating device, that is, , and connect the radio frequency electrode group.
步骤四，对出血部位进行热凝止血，并在热凝止血过程进行实时影像监控，如止血成功，则进入步骤五；否则，持续对出血部位进行热凝止血，直到止血成功。Step 4, perform thermal coagulation hemostasis on the bleeding site, and perform real-time video monitoring during the thermal coagulation hemostasis process. If the hemostasis is successful, proceed to step 5; otherwise, continue to perform thermal coagulation hemostasis on the bleeding site until the hemostasis is successful.
步骤五，自适应调控模块保持射频能量发生设备关闭，即。保持射频电极组断开状态。开启脉冲电场能量发生设备，即，并连接脉冲电场电极组。进入步骤二，时序调控示意图如图5所示。Step 5: The adaptive control module keeps the RF energy generating device turned off. Keep the RF electrode group disconnected. Turn on the pulsed electric field energy generator. , and connect the pulse electric field electrode group. Enter step 2, the timing control schematic diagram is shown in Figure 5.
在本场景中，当在靶区进行脉冲电场消融治疗出现出血时，可以通过消融治疗时序函数快速调整消融方法进行止血，从而提高了消融治疗手术的安全性。In this scenario, when bleeding occurs during pulsed electric field ablation treatment in the target area, the ablation method can be quickly adjusted through the ablation treatment timing function to stop the bleeding, thereby improving the safety of the ablation treatment operation.
4、消融参数确定模块。本模块用于通过目标患者的术前信息和术中影像确定所述目标消融方法的消融参数，如目标消融方法为脉冲电场消融时，该消融参数则为电压，脉宽，脉冲个数等。当目标消融方法为射频消融时，该消融参数则为电流功率，工作频率等。确定消融参数后，将该消融参数发送给复合物理场能量发生模块，使复合物理场能量发生模块控制各个消融能量发生装置依据该消融参数生成能量。4. Ablation parameter determination module. This module is used to determine the ablation parameters of the target ablation method through the preoperative information and intraoperative images of the target patient. For example, when the target ablation method is pulsed electric field ablation, the ablation parameters are voltage, pulse width, number of pulses, etc. When the target ablation method is radiofrequency ablation, the ablation parameters are current power, operating frequency, etc. After determining the ablation parameters, the ablation parameters are sent to the composite physical field energy generation module, so that the composite physical field energy generation module controls each ablation energy generation device to generate energy according to the ablation parameters.
至此，完成图1所示的系统模块说明。At this point, the description of the system modules shown in Figure 1 is completed.
在上述实施例中，系统集成了多种消融能量发生设备，并通过消融治疗时序函数对其进行控制，一体化电极针则包含了用于各个能量发生设备对应的电极组。在消融手术过程中，通过预设的消融方法对消融区域进行治疗并对该消融区域进行监控，当确定需要调整消融方法时，则自适应的通过消融治疗时序函数进行调整，使得调整后的能量发生设备生成能量并通过一体化电极针上该能量对应的电极组发射。这实现了在消融手术过程中，通过一体化单根电极针自适应发射多种物理场能量，解决了平行针操作难题和止血/种植风险问题。In the above embodiment, the system integrates a variety of ablation energy generating devices and controls them through ablation treatment timing functions, and the integrated electrode needle includes electrode groups corresponding to each energy generating device. During the ablation procedure, the ablation area is treated and monitored by a preset ablation method. When it is determined that the ablation method needs to be adjusted, the ablation treatment timing function is adaptively adjusted so that the adjusted energy generating device generates energy and transmits it through the electrode group corresponding to the energy on the integrated electrode needle. This realizes the adaptive emission of multiple physical field energies through an integrated single electrode needle during the ablation procedure, solving the problem of parallel needle operation and the risk of hemostasis/implantation.
在另一个实施例中，上述系统还包括影像导航功能模块；In another embodiment, the above system further includes an image navigation function module;
该模块用于通过实时影像在执行进退针操作时对所述一体化电极针的周围区域进行实时监控，根据所述实时影像调整进退针路径并根据调整后的进退针路径进行导航。This module is used to monitor the surrounding area of the integrated electrode needle in real time when performing needle advancement and withdrawal operations through real-time images, adjust the needle advancement and withdrawal path according to the real-time images, and navigate according to the adjusted needle advancement and withdrawal path.
在另一个实施例中，上述系统还包括模拟仿真模块；In another embodiment, the above system further comprises a simulation module;
该模块用于所述复合物理场能量发生模块依据所述消融参数生成能量之前，根据所述消融参数进行消融模拟仿真，并根据所述消融模拟仿真生成的模拟消融区域确定是否符合预期；This module is used for performing ablation simulation according to the ablation parameters before the composite physical field energy generation module generates energy according to the ablation parameters, and determining whether the simulated ablation area generated by the ablation simulation meets expectations;
当符合时，通知所述复合物理场能量发生模块依据所述消融参数发送能量；When the conditions are met, informing the composite physical field energy generation module to send energy according to the ablation parameters;
当不符合时，调整所述消融参数，并根据调整后的消融参数再次进行消融模拟仿真，直至所述模拟消融区域符合预期时，通过所述复合物理场能量发生模块依据调整后的消融参数发送能量。When it does not meet the requirements, the ablation parameters are adjusted, and ablation simulation is performed again according to the adjusted ablation parameters, until the simulated ablation area meets expectations, and energy is sent according to the adjusted ablation parameters through the composite physical field energy generation module.
在本模块中，以脉冲电场为例，模拟仿真的过程如下：In this module, taking the pulse electric field as an example, the simulation process is as follows:
通过，和确定待治疗区域的电场强度E，其中，σ为电导率，可以用公式表示, 电导率与温度和外加消融电场有关，具体数值可以通过传感器实时测量。U为电势，U的正电极边界电势为预设值U0，U0可以根据不同的消融设备而设置不同的值，负电极边界电势为接地0V。pass ,and Determine the electric field strength E of the area to be treated, whereσ is the conductivity, which can be expressed as Indicates that conductivity is related to temperature and external ablation electric field, and the specific value can be measured in real time by sensors. U is the electric potential, and the positive electrode boundary potential of U is the preset value U0. U0 can be set to different values according to different ablation devices, and the negative electrode boundary potential is grounded 0V.
上述方程中的主待解参数电场强度E和电势U可以通过COMSOL有限元软件或其他类似软件求解。The main parameters to be solved in the above equations, the electric field intensity E and the electric potential U, can be solved by COMSOL finite element software or other similar software.
确定电场强度E后，可以将电场强度不小于预设消融阈值场强的区域确定为预估脉冲电场消融区域，因此，可以将的区域确定为模拟脉冲电场消融区域。为预设消融阈值场强，为时间参数，为整个待治疗区域的三维空间参数。After the electric field strength E is determined, the area where the electric field strength is not less than the preset ablation threshold field strength can be determined as the estimated pulse electric field ablation area. The area is determined as the simulated pulse electric field ablation area. is the preset ablation threshold field strength, is the time parameter, It is the three-dimensional spatial parameter of the entire area to be treated.
确定模拟脉冲电场消融区域后，将其与术前治疗方案中预设的消融范围进行对比。若两者的重复率小于预设值，则说明通过上述治疗参数进行消融治疗的效果不符合预期，需要对其进行调整后重新预估对比。直至重复率超过预设值时，再执行根据该治疗参数对目标患者进行脉冲电场消融治疗的步骤。After the simulated pulse electric field ablation area is determined, it is compared with the preset ablation range in the preoperative treatment plan. If the repetition rate of the two is less than the preset value, it means that the effect of ablation treatment using the above treatment parameters does not meet expectations and needs to be adjusted and re-estimated and compared. When the repetition rate exceeds the preset value, the step of performing pulse electric field ablation treatment on the target patient according to the treatment parameters is executed.
在本模块中，在进行消融治疗前先对该治疗参数进行模拟消融，使得可以在消融治疗之前确定最佳的治疗参数。从而提高消融手术的精确性和安全性。In this module, the treatment parameters are simulated before ablation therapy, so that the best treatment parameters can be determined before ablation therapy, thereby improving the accuracy and safety of ablation surgery.
如图6所示，本申请还提供了一种基于一体化单针的复合物理场自适应消融装置，所述装置包括：As shown in FIG6 , the present application also provides a composite physical field adaptive ablation device based on an integrated single needle, the device comprising:
消融参数确定单元601，用于通过目标患者的术前信息和术中影像确定进行消融治疗的消融参数；an ablation parameter determination unit 601, configured to determine ablation parameters for ablation treatment based on preoperative information and intraoperative images of a target patient;
自适应调控单元602，用于通过实时影像对目标消融区域进行监控，并根据监控结果调整所述消融治疗时序函数；An adaptive control unit 602 is used to monitor the target ablation area through real-time images and adjust the ablation treatment timing function according to the monitoring results;
复合物理场能量发生单元603，用于通过所述消融治疗时序函数确定目标消融方法，根据所述目标消融方法确定目标能量类型，根据所述目标能量类型对应的消融参数生成能量，并通过一体化电极针对所述目标消融区域发射所述能量进行消融治疗，其中，所述一体化电极针包含若干个不同类型的电极组。The composite physical field energy generating unit 603 is used to determine the target ablation method through the ablation treatment timing function, determine the target energy type according to the target ablation method, generate energy according to the ablation parameters corresponding to the target energy type, and transmit the energy to the target ablation area through the integrated electrode for ablation treatment, wherein the integrated electrode needle includes several different types of electrode groups.
在另一个实施例中，所述复合物理场能量发生单元中的不同类型的电极组包括射频电极组和脉冲电场电极组；In another embodiment, the different types of electrode groups in the composite physical field energy generating unit include a radio frequency electrode group and a pulsed electric field electrode group;
所述通过消融治疗时序函数确定目标消融方法包括：The method for determining a target ablation through an ablation treatment timing function includes:
根据电极组的类型确定所述消融治疗时序函数包含射频消融时序函数和脉冲电场消融时序函数，确定所述射频消融时序函数为，所述脉冲电场消融时序函数为；According to the type of electrode group, the ablation treatment timing function includes a radiofrequency ablation timing function and a pulsed electric field ablation timing function, and the radiofrequency ablation timing function is determined to be , the pulse electric field ablation timing function is ;
确定所述和的值，当所述时，通过所述射频电极组发射能量，当所述，通过所述脉冲电场电极组发射能量。Determine the and When the value of When the radio frequency electrode group transmits energy, , emitting energy through the pulsed electric field electrode group.
在另一个实施例中，所述复合物理场能量发生单元包括电源模块，控制模块，若干个不同的能量驱动模块，若干个不同的能量产生模块，输出切换模块以及能量输出接口；In another embodiment, the composite physical field energy generation unit includes a power supply module, a control module, a plurality of different energy driving modules, a plurality of different energy generation modules, an output switching module and an energy output interface;
所述电源模块包含AC-DC转换模块，DC-DC转换模块，用于进行电源转换并为其他模块提供所需的电源；The power supply module includes an AC-DC conversion module and a DC-DC conversion module, which are used to perform power conversion and provide the required power for other modules;
所述控制模块用于为所述能量驱动模块提供所需的驱动信号，从而产生所述能量产生模块所需的驱动信号，并为不同的能量产生模块之间提供相应的交互信息、采集反馈信号发送给所述自适应调控模块；The control module is used to provide the required driving signal for the energy driving module, thereby generating the driving signal required by the energy generating module, and providing corresponding interactive information between different energy generating modules, collecting feedback signals and sending them to the adaptive control module;
所述输出切换模块和能量输出接口根据所述消融时序函数切换能量并进行输出。The output switching module and the energy output interface switch the energy and output it according to the ablation timing function.
在另一个实施例中，所述装置还包括：In another embodiment, the apparatus further comprises:
影像导航功能单元604，用于通过实时影像在执行进退针操作时对所述一体化电极针的周围区域进行实时监控，根据所述实时影像调整进退针路径并根据调整后的进退针路径进行导航。The image navigation function unit 604 is used to monitor the surrounding area of the integrated electrode needle in real time through real-time images when performing needle advancement and withdrawal operations, adjust the needle advancement and withdrawal path according to the real-time images, and navigate according to the adjusted needle advancement and withdrawal path.
在另一个实施例中，所述装置还包括：In another embodiment, the apparatus further comprises:
模拟仿真单元605，用于根据所述目标能量类型对应的消融参数生成能量之前，根据所述消融参数进行消融模拟仿真，并根据所述消融模拟仿真生成的模拟消融区域确定是否符合预期；A simulation unit 605 is used for performing ablation simulation according to the ablation parameters before generating energy according to the ablation parameters corresponding to the target energy type, and determining whether the simulated ablation area generated by the ablation simulation meets expectations;
当符合时，通知所述复合物理场能量发生模块依据所述消融参数发送能量；When the conditions are met, informing the composite physical field energy generation module to send energy according to the ablation parameters;
当不符合时，调整所述消融参数，并根据调整后的消融参数再次进行消融模拟仿真，直至所述模拟消融区域符合预期时，通过所述复合物理场能量发生模块依据调整后的消融参数发送能量。When it does not meet the requirements, the ablation parameters are adjusted, and ablation simulation is performed again according to the adjusted ablation parameters, until the simulated ablation area meets expectations, and energy is sent according to the adjusted ablation parameters through the composite physical field energy generation module.
本发明上述实施例中提供了一种基于一体化单针的复合物理场自适应消融系统，并基于该系统提供了一种基于一体化单针的复合物理场自适应消融装置，通过上述系统和装置，解决了消融治疗手术中的平行针操作难题和止血/种植风险问题。The above-mentioned embodiment of the present invention provides a composite physical field adaptive ablation system based on an integrated single needle, and based on this system provides a composite physical field adaptive ablation device based on an integrated single needle. Through the above-mentioned system and device, the parallel needle operation problem and hemostasis/implantation risk problems in ablation treatment surgery are solved.
本实施例还公开了一种计算机设备，如图7所示，计算机设备包含处理器和存储器，所述存储器中存储由至少一条指令，所述至少一条指令由所述处理器加载并执行以实现上述任一所述的基于一体化单针的复合物理场自适应消融系统的功能。This embodiment also discloses a computer device, as shown in FIG7 , the computer device includes a processor and a memory, the memory stores at least one instruction, and the at least one instruction is loaded and executed by the processor to implement any of the functions of the above-mentioned integrated single-needle-based composite physical field adaptive ablation system.
此外，上述示例的基于一体化单针的复合物理场自适应消融装置的实施方式中，各程序模块的逻辑划分仅是举例说明，实际应用中可以根据需要，例如出于相应硬件的配置要求或者软件的实现的便利考虑，将上述功能分配由不同的程序模块完成，即将所述基于一体化单针的复合物理场自适应消融装置的内部结构划分成不同的程序模块，以完成以上描述的全部或者部分功能。In addition, in the above-mentioned example implementation of the composite physical field adaptive ablation device based on an integrated single needle, the logical division of each program module is only an example. In actual applications, the above-mentioned functions can be assigned to different program modules as needed, for example, for the convenience of corresponding hardware configuration requirements or software implementation. That is, the internal structure of the composite physical field adaptive ablation device based on an integrated single needle is divided into different program modules to complete all or part of the functions described above.
以上所述仅为本申请的较佳实施例而已，并不用以限制本申请，凡在本申请的精神和原则之内，所做的任何修改、等同替换、改进等，均应包含在本申请保护的范围之内。The above description is only a preferred embodiment of the present application and is not intended to limit the present application. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present application shall be included in the scope of protection of the present application.
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| CN202411117078.1ACN118634028B (en) | 2024-08-15 | 2024-08-15 | Composite physical field self-adaptive ablation system and device based on integrated single needle |
| Application Number | Priority Date | Filing Date | Title |
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| CN202411117078.1ACN118634028B (en) | 2024-08-15 | 2024-08-15 | Composite physical field self-adaptive ablation system and device based on integrated single needle |
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| CN202411117078.1AActiveCN118634028B (en) | 2024-08-15 | 2024-08-15 | Composite physical field self-adaptive ablation system and device based on integrated single needle |
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