技术领域Technical Field
本发明属于医疗设备技术领域，涉及一种精准定位的无创脊髓电刺激方法及系统。The present invention belongs to the technical field of medical equipment and relates to a precisely positioned non-invasive spinal cord electrical stimulation method and system.
背景技术Background technique
近年来，脊髓电刺激(SCS)作为一种治疗慢性疼痛和其他神经系统疾病的方法，已经得到了广泛的研究和应用。尽管SCS技术在某些领域显示出了潜力，但其应用受到了诸多限制。一方面，传统的SCS技术主要依赖于植入式电极来直接刺激脊髓，这种侵入性方法存在感染、组织损伤和长期维护等风险。另一方面，现有的SCS技术难以精确地针对脊髓中的特定深层结构，这限制了其在治疗某些病症中的效果和应用范围。In recent years, spinal cord stimulation (SCS) has been widely studied and applied as a treatment for chronic pain and other neurological diseases. Although SCS technology has shown potential in certain areas, its application is subject to many limitations. On the one hand, traditional SCS technology mainly relies on implanted electrodes to directly stimulate the spinal cord, an invasive method that carries risks such as infection, tissue damage, and long-term maintenance. On the other hand, existing SCS technology has difficulty accurately targeting specific deep structures in the spinal cord, which limits its effectiveness and scope of application in treating certain conditions.
此外，虽然有研究尝试通过调整电极的位置和刺激参数来提高刺激的精确度和效果，但这些方法仍然无法解决根本的局限性，包括侵入性的风险以及非侵入性方法对深层结构定位的限制。因此，急需开发一种新的脊髓刺激方法，既能非侵入性地操作，又能精确地作用于脊髓的特定深层结构。In addition, although some studies have attempted to improve the accuracy and effect of stimulation by adjusting the position of electrodes and stimulation parameters, these methods still cannot solve the fundamental limitations, including the risk of invasiveness and the limitations of non-invasive methods on the positioning of deep structures. Therefore, it is urgent to develop a new spinal cord stimulation method that can operate non-invasively and accurately act on specific deep structures of the spinal cord.
发明内容Summary of the invention
为了解决传统脊髓电刺激方法中存在的一系列限制和挑战，尤其是侵入性问题、精确性不足以及无法有效达到脊髓深层结构的问题，为此，本发明提出了一种精准定位的无创脊髓电刺激方法及系统，显著降低了治疗的风险和患者的不适，展现了巨大的临床应用潜力。In order to solve a series of limitations and challenges in traditional spinal cord stimulation methods, especially the problems of invasiveness, lack of precision and inability to effectively reach the deep structures of the spinal cord, the present invention proposes a precisely positioned non-invasive spinal cord stimulation method and system, which significantly reduces the risk of treatment and patient discomfort, and shows great potential for clinical application.
所采用的技术方案如下：The technical solutions adopted are as follows:
一方面，本发明提供了一种精准定位的无创脊髓电刺激方法，确定需要刺激的目标脊髓区域；在目标脊髓区域周围放置至少两组产生频率相近交变电场的高频率电极；控制各组电极产生高频电场，使其目标脊髓区域相交后产生低频干涉电场，刺激目标脊髓区域。On the one hand, the present invention provides a precisely positioned non-invasive spinal cord electrical stimulation method, which determines the target spinal cord area that needs to be stimulated; places at least two groups of high-frequency electrodes that generate alternating electric fields with similar frequencies around the target spinal cord area; controls each group of electrodes to generate a high-frequency electric field so that when they intersect in the target spinal cord area, a low-frequency interference electric field is generated to stimulate the target spinal cord area.
优选地，所采用的高频率电极产生至少10KHz的交变电场，且在需要刺激的目标脊髓区域产生不大于60Hz的低频干涉电场，通过调整各组电极的位置、角度以及施加电场的频率，控制低频干涉电场在脊髓中的位置。Preferably, the high-frequency electrodes used generate an alternating electric field of at least 10 kHz, and a low-frequency interference electric field of no more than 60 Hz in the target spinal cord area that needs to be stimulated. The position of the low-frequency interference electric field in the spinal cord is controlled by adjusting the position and angle of each group of electrodes and the frequency of the applied electric field.
进一步地，通过测量目标脊髓区域的电阻率，自动控制至少两组电极产生的高频电场的频率差，使频率差控制在不大于60Hz。Furthermore, by measuring the resistivity of the target spinal cord area, the frequency difference of the high-frequency electric field generated by at least two groups of electrodes is automatically controlled so that the frequency difference is controlled to be no greater than 60 Hz.
进一步地，根据预定的各目标脊髓区域的电阻率与频率差之间的关系，自动调整各组电极间的频率差。Furthermore, the frequency difference between each group of electrodes is automatically adjusted according to the relationship between the resistivity of each target spinal cord area and the frequency difference.
进一步地，测量目标脊髓区域产生的生理反应，根据生理反应数据评估电刺激效果，并进行目标脊髓区域的电场频率、电场强度、电刺激持续时间及电压或电流的调整，并保持电压和电流在人体安全范围内。Furthermore, the physiological response produced in the target spinal cord area is measured, the effect of electrical stimulation is evaluated based on the physiological response data, and the electric field frequency, electric field strength, electrical stimulation duration and voltage or current of the target spinal cord area are adjusted, and the voltage and current are kept within the safe range for the human body.
另一方面，本发明还提供了一种无创脊髓电刺激系统，所述系统包括：On the other hand, the present invention also provides a non-invasive spinal cord electrical stimulation system, the system comprising:
至少两组电极，用于配置于目标脊髓区域，以产生交变电场；at least two sets of electrodes for being arranged in a target spinal cord region to generate an alternating electric field;
控制单元，与各组所述电极电性连接，用于独立调节每组所述电极产生电场的频率、强度和相位，使其在目标脊髓区域内产生低频干涉电场。A control unit is electrically connected to each group of electrodes and is used to independently adjust the frequency, intensity and phase of the electric field generated by each group of electrodes so that a low-frequency interference electric field is generated in the target spinal cord area.
优选地，两组所述电极产生的电场频率为10KHz和10KHz±60Hz，经干涉产生的低频电场频率为1～60Hz。Preferably, the electric field frequencies generated by the two groups of electrodes are 10 KHz and 10 KHz±60 Hz, and the low-frequency electric field frequency generated by interference is 1-60 Hz.
优选地，所述电极为贴在皮肤表面上的非侵入性电极，配置用于通过皮肤表面向目标脊髓区域内部施加电场。Preferably, the electrode is a non-invasive electrode attached to the surface of the skin, and is configured to apply an electric field to the inside of the target spinal cord area through the surface of the skin.
进一步地，所述系统还包括反馈单元，用于监测治疗过程中的电场及患者肌肉活动，所述反馈单元与所述控制单元电性连接，所述控制单元根据所述反馈单元的监测结果自动调节目标脊髓区域的电场参数。Furthermore, the system also includes a feedback unit for monitoring the electric field and patient muscle activity during treatment. The feedback unit is electrically connected to the control unit, and the control unit automatically adjusts the electric field parameters of the target spinal cord area according to the monitoring results of the feedback unit.
进一步地，所述系统还包括：Furthermore, the system further comprises:
传感器，用于测量目标脊髓区域及治疗部位的生理反应；Sensors to measure physiological responses in the targeted spinal cord area and treatment site;
分析单元，其分别与所述传感器和控制单元电性连接，所述分析单元根据所述传感器测量的生理反应数据对电刺激效果进行评估，并根据电刺激效果通过所述控制单元调整各组所述电极的电刺激参数。An analysis unit is electrically connected to the sensor and the control unit respectively, and the analysis unit evaluates the electrical stimulation effect according to the physiological response data measured by the sensor, and adjusts the electrical stimulation parameters of each group of electrodes through the control unit according to the electrical stimulation effect.
优选地，所述电极具有可调节的形状或位置，用于在目标脊髓区域定位低频干涉电场。Preferably, the electrodes have an adjustable shape or position for localizing the low frequency interfering electric field at a target spinal cord region.
相对于现有技术，本发明技术方案具有如下优点：Compared with the prior art, the technical solution of the present invention has the following advantages:
A.本发明使用至少两组电极，分别产生两个高频率(例如，10KHz和10.01KHz)但频率相近的交变电场，生成时间干涉电场，这些电场独立对脊髓深层结构几乎没有影响，但在它们交叠的区域内，会通过频率差(即10Hz)产生一个有效的低频电场，这个低频干涉场能够穿透至脊髓深处，激活目标神经元而不影响表层组织；A. The present invention uses at least two groups of electrodes to generate two high-frequency (e.g., 10KHz and 10.01KHz) but similar-frequency alternating electric fields, generating a time-interference electric field. These electric fields have almost no effect on the deep structure of the spinal cord independently, but in the area where they overlap, an effective low-frequency electric field is generated through the frequency difference (i.e., 10Hz). This low-frequency interference field can penetrate deep into the spinal cord and activate target neurons without affecting the surface tissue;
B.本发明方法和系统通过调整电极的位置、角度以及施加电场的频率，可以精确控制低频干涉场在脊髓中的位置，从而实现对特定脊髓深层结构的精确刺激，这种控制策略允许个性化调整刺激参数，且方便针对不同患者情况对电极进行分布，可以对更多的病症进行治疗，做到无创高精度深层定位需刺激的目标区域，满足了不同患者的治疗需求。B. The method and system of the present invention can accurately control the position of the low-frequency interference field in the spinal cord by adjusting the position and angle of the electrodes and the frequency of the applied electric field, thereby achieving precise stimulation of specific deep structures of the spinal cord. This control strategy allows personalized adjustment of stimulation parameters and facilitates the distribution of electrodes according to different patient conditions. It can treat more diseases and achieve non-invasive and high-precision deep positioning of the target area to be stimulated, meeting the treatment needs of different patients.
C.本发明方法和系统提高了脊髓电刺激的安全性和舒适度，实现对脊髓深层结构的精确无创刺激，以及扩展脊髓电刺激在治疗慢性疼痛、促进神经修复和治疗其他脊髓相关疾病方面的应用范围。此外，该方法有望通过其非侵入性和高精度的特点，为患者提供更为有效和舒适的治疗方案。C. The method and system of the present invention improve the safety and comfort of spinal cord electrical stimulation, achieve accurate non-invasive stimulation of the deep structures of the spinal cord, and expand the application scope of spinal cord electrical stimulation in treating chronic pain, promoting nerve repair and treating other spinal cord-related diseases. In addition, the method is expected to provide patients with more effective and comfortable treatment options through its non-invasive and high-precision characteristics.
D.本发明的实施不仅为脊髓电刺激技术带来了创新，而且通过其独特的技术手段，克服了传统方法的主要限制，为深层脊髓结构的治疗提供了新的可能性。相比于传统的脊髓刺激方法，本系统预期能提供更为安全、有效且用户友好的治疗方案。D. The implementation of the present invention not only brings innovation to spinal cord electrical stimulation technology, but also, through its unique technical means, overcomes the main limitations of traditional methods and provides new possibilities for the treatment of deep spinal cord structures. Compared with traditional spinal cord stimulation methods, this system is expected to provide a safer, more effective and user-friendly treatment solution.
附图说明BRIEF DESCRIPTION OF THE DRAWINGS
为了更清楚地说明本发明具体实施方式，下面将对具体实施方式中所需要使用的附图作简单地介绍，显而易见地，下面描述中的附图是本发明的一些实施方式，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图获得其他的附图。In order to more clearly illustrate the specific embodiments of the present invention, the drawings required for use in the specific embodiments will be briefly introduced below. Obviously, the drawings described below are some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.
图1是本发明提供的脊髓电刺激方法框图；FIG1 is a block diagram of a spinal cord electrical stimulation method provided by the present invention;
图2是本发明提供的系统组成结构图；FIG2 is a structural diagram of the system provided by the present invention;
图3是本发明提供的以腰背部脊髓神经元为靶点的电极分布示意图；FIG3 is a schematic diagram of electrode distribution targeting lumbar spinal cord neurons provided by the present invention;
图4是本发明提供的以颈部(上肢皮节)脊髓神经元为靶点的电极分布示意图；FIG4 is a schematic diagram of electrode distribution targeting cervical (upper limb dermatomes) spinal cord neurons provided by the present invention;
图5是本发明提供的以多个脊髓皮节部位为刺激靶点的电极分布示意图。FIG. 5 is a schematic diagram of electrode distribution with multiple spinal cord dermatomes as stimulation targets provided by the present invention.
图中：1-脊髓区域；2-电极；3-目标脊髓区域。In the figure: 1- spinal cord area; 2- electrode; 3- target spinal cord area.
具体实施方式Detailed ways
下面将结合附图对本发明的技术方案进行清楚、完整地描述，显然，所描述的实施例是本发明一部分实施例，而不是全部的实施例。基于本发明的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。The technical solution of the present invention will be described clearly and completely below in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.
如图1所示，本发明提供了一种精准定位的无创脊髓电刺激方法，确定需要刺激的目标脊髓区域；在目标脊髓区域周围的皮肤上放置至少两组产生频率相近交变电场的高频率电极；控制各组电极在目标脊髓区域产生高频电场，并在目标脊髓区域相交后产生低频干涉电场，刺激目标脊髓区域。所采用的高频率电极产生至少10KHz的交变电场，且在需要刺激的目标脊髓区域产生不大于60Hz的低频干涉电场。为了满足不同患者需求，可以通过调整各组电极的位置、角度以及电场频率，控制低频干涉电场在脊髓中的位置。As shown in Figure 1, the present invention provides a non-invasive spinal cord electrical stimulation method with precise positioning, which determines the target spinal cord area that needs to be stimulated; places at least two groups of high-frequency electrodes that generate alternating electric fields with similar frequencies on the skin around the target spinal cord area; controls each group of electrodes to generate a high-frequency electric field in the target spinal cord area, and generates a low-frequency interference electric field after intersecting the target spinal cord area to stimulate the target spinal cord area. The high-frequency electrodes used generate an alternating electric field of at least 10KHz, and a low-frequency interference electric field of no more than 60Hz in the target spinal cord area that needs to be stimulated. In order to meet the needs of different patients, the position, angle and electric field frequency of each group of electrodes can be adjusted to control the position of the low-frequency interference electric field in the spinal cord.
作为本发明进一步优选的实施方法，通过测量目标脊髓区域的电阻率，自动控制至少两组电极产生的高频电场的频率差，使频率差控制在不大于60Hz。根据预定的各目标脊髓区域的电阻率与频率差之间的关系，自动调整各组电极间的频率差。As a further preferred implementation method of the present invention, the frequency difference of the high-frequency electric field generated by at least two groups of electrodes is automatically controlled by measuring the resistivity of the target spinal cord area, so that the frequency difference is controlled to be no greater than 60 Hz. The frequency difference between each group of electrodes is automatically adjusted according to the predetermined relationship between the resistivity of each target spinal cord area and the frequency difference.
作为本发明进一步优选的实施方法，测量目标脊髓区域产生的生理反应，根据生理反应数据评估电刺激效果，并进行目标脊髓区域的电场频率、强度和电刺激持续时间的调整，并控制电流和电压在人体的安全范围内。As a further preferred implementation method of the present invention, the physiological response produced in the target spinal cord area is measured, the electrical stimulation effect is evaluated based on the physiological response data, and the electric field frequency, intensity and duration of electrical stimulation in the target spinal cord area are adjusted, and the current and voltage are controlled within a safe range for the human body.
如图2所示，本发明还提供了一种无创脊髓电刺激系统，系统包括：As shown in FIG2 , the present invention further provides a non-invasive spinal cord electrical stimulation system, the system comprising:
至少两组电极，用于配置于目标脊髓区域周围的皮肤上，以产生交变电场；at least two sets of electrodes for being placed on the skin around the target spinal cord area to generate an alternating electric field;
控制单元，与各所述电极电性连接，用于独立调节每组所述电极产生的电场频率，使其在目标脊髓区域内产生低频干涉电场。A control unit is electrically connected to each of the electrodes and is used to independently adjust the frequency of the electric field generated by each group of electrodes so that a low-frequency interference electric field is generated in the target spinal cord area.
两组所述电极产生的电场频率为10KHz和10KHz±60Hz，经干涉产生的低频电场频率为1～60Hz。The electric field frequencies generated by the two groups of electrodes are 10 KHz and 10 KHz±60 Hz, and the low-frequency electric field frequency generated by interference is 1-60 Hz.
本发明优选的电极为贴附在皮肤表面上的非侵入性电极，配置用于通过皮肤表面向目标脊髓区域内部施加电场。The preferred electrodes of the present invention are non-invasive electrodes attached to the surface of the skin and configured to apply an electric field to the interior of the target spinal cord area through the surface of the skin.
作为本发明进一步优选的系统，在系统中还设有反馈单元，用于监测治疗过程中的电场及患者肌肉活动，反馈单元与控制单元电性连接，控制单元根据反馈单元的监测结果自动调节目标脊髓区域的电场参数。As a further preferred system of the present invention, a feedback unit is also provided in the system for monitoring the electric field and the patient's muscle activity during the treatment process. The feedback unit is electrically connected to the control unit, and the control unit automatically adjusts the electric field parameters of the target spinal cord area according to the monitoring results of the feedback unit.
作为本发明进一步优选的系统，系统还包括：As a further preferred system of the present invention, the system further includes:
传感器，用于测量目标脊髓区域及治疗部位的生理反应；Sensors to measure physiological responses in the targeted spinal cord area and treatment site;
分析单元，其分别与所述传感器和控制单元电性连接，所述分析单元根据所述传感器测量的生理反应数据对电刺激效果进行评估，并根据电刺激效果通过所述控制单元调整各组所述电极的电刺激参数。An analysis unit is electrically connected to the sensor and the control unit respectively, and the analysis unit evaluates the electrical stimulation effect according to the physiological response data measured by the sensor, and adjusts the electrical stimulation parameters of each group of electrodes through the control unit according to the electrical stimulation effect.
所采用的电极优选具有可调节的形状或位置，用于在目标脊髓区域定位低频干涉电场。如图3和图4中所示的四组电极的分布情况，只要目标脊髓区域确定，可以在其周围不同位置设置多组成对电极(如图5)，使各组电极在目标脊髓区域形成低于60Hz的低频干涉电场。The electrodes used preferably have an adjustable shape or position for positioning the low-frequency interference electric field in the target spinal cord region. As shown in the distribution of the four groups of electrodes in Figures 3 and 4, as long as the target spinal cord region is determined, multiple groups of paired electrodes can be set at different positions around it (as shown in Figure 5), so that each group of electrodes forms a low-frequency interference electric field below 60Hz in the target spinal cord region.
本发明通过多组电极所产生的高频电场经在目标脊髓区域进行交叠后，会通过频率差(即10Hz)产生一个有效的低频电场，这个低频干涉场能够穿透至脊髓深处，激活目标神经元而不影响表层组织，且通过调整电极的位置、角度以及施加电场的频率，可以精确控制低频干涉场在脊髓中的位置，从而实现对特定脊髓深层结构的精确刺激，相对于现有技术，本发明所采用的控制策略允许个性化调整刺激参数，方便根据病症情况调整电极位置，可以满足更多不同病症患者的治疗需求，实现无创精准电刺激目标神经元，达到镇痛等治疗效果。The high-frequency electric field generated by multiple groups of electrodes in the present invention will overlap in the target spinal cord area, and then generate an effective low-frequency electric field through the frequency difference (i.e., 10Hz). This low-frequency interference field can penetrate deep into the spinal cord and activate target neurons without affecting the surface tissue. By adjusting the position and angle of the electrodes and the frequency of the applied electric field, the position of the low-frequency interference field in the spinal cord can be precisely controlled, thereby achieving precise stimulation of specific deep structures of the spinal cord. Compared with the prior art, the control strategy adopted in the present invention allows personalized adjustment of stimulation parameters, which is convenient for adjusting the electrode position according to the condition of the disease, and can meet the treatment needs of more patients with different diseases, achieve non-invasive and precise electrical stimulation of target neurons, and achieve therapeutic effects such as analgesia.
实施例1：Embodiment 1:
电极配置：本系统由两组外部电极组成，每组电极包括两个或多个电极。这些电极被定位于患者脊柱周围，以便能够在脊髓区域内产生电场。Electrode Configuration: The system consists of two sets of external electrodes, each set of two or more electrodes, which are positioned around the patient's spine to generate an electric field in the spinal cord area.
控制单元：用于独立调节每组电极产生的电场的频率、强度和相位，控制单元配备有用户界面，允许医疗专业人员根据治疗需求调整刺激参数。Control Unit: Used to independently adjust the frequency, intensity and phase of the electric field generated by each set of electrodes. The control unit is equipped with a user interface that allows medical professionals to adjust the stimulation parameters according to treatment needs.
技术参数：Technical Parameters:
电场频率：第一组电极产生10KHz的交变电场，第二组电极产生10.01KHz的交变电场。电极频率可随时调整，以产生不同的干涉频率。Electric field frequency: The first set of electrodes generates an alternating electric field of 10KHz, and the second set of electrodes generates an alternating electric field of 10.01KHz. The electrode frequency can be adjusted at any time to generate different interference frequencies.
干涉频率：两个高频电场在脊髓的目标区域相交，产生10Hz的低频干涉电场。Interference frequency: Two high-frequency electric fields intersect at the target area of the spinal cord, generating a low-frequency interfering electric field of 10 Hz.
电场强度：根据治疗需求调整，但不超过人体安全电流，以确保安全性。Electric field strength: adjusted according to treatment needs, but not exceeding the safe current for the human body to ensure safety.
操作步骤：Steps:
1.定位电极：根据患者的具体病情，使用医学影像技术(如MRI)确定脊髓中需刺激的精确位置，然后，根据这一信息定位电极。1. Positioning the electrodes: Based on the patient's specific condition, medical imaging technology (such as MRI) is used to determine the exact location in the spinal cord that needs stimulation. The electrodes are then positioned based on this information.
2.设定刺激参数：在控制单元上设定每组电极的频率和电场强度，设定的参数应产生所需的干涉电场，以精确刺激目标区域。2. Set stimulation parameters: Set the frequency and electric field strength of each group of electrodes on the control unit. The set parameters should generate the required interference electric field to accurately stimulate the target area.
3.启动刺激程序：启动控制单元，开始刺激程序，刺激持续时间和频率根据治疗方案而定。3. Start the stimulation program: Start the control unit and start the stimulation program. The duration and frequency of stimulation depend on the treatment plan.
4.监测与调整：在刺激过程中，监测患者的生理反应，如有必要，调整刺激参数以优化治疗效果。4. Monitoring and adjustment: During the stimulation process, monitor the patient's physiological response and, if necessary, adjust the stimulation parameters to optimize the treatment effect.
5.评估治疗效果：刺激结束后，评估治疗的即时效果，并在必要时调整后续治疗计划。5. Evaluate treatment effects: After the stimulation is completed, evaluate the immediate effects of the treatment and adjust the subsequent treatment plan if necessary.
通过本实施例，预期能够无创地精确刺激脊髓深层结构，以治疗慢性疼痛、促进神经修复或改善其他脊髓相关疾病的症状。相比于传统的脊髓刺激方法，本系统预期能提供更为安全、有效且用户友好的治疗方案。Through this embodiment, it is expected that the deep structures of the spinal cord can be accurately stimulated non-invasively to treat chronic pain, promote nerve repair, or improve the symptoms of other spinal cord-related diseases. Compared with traditional spinal cord stimulation methods, this system is expected to provide a safer, more effective and user-friendly treatment solution.
实施例2：治疗慢性背痛Example 2: Treatment of chronic back pain
电极配置：四个电极围绕患者的腰部区域放置，两对电极分别生成10KHz和10.03KHz的高频电场。Electrode configuration: Four electrodes are placed around the patient's lumbar area, and two pairs of electrodes generate high-frequency electric fields of 10KHz and 10.03KHz respectively.
控制单元：允许对电场频率进行微调，以生成约30Hz的低频干涉电场，深入患者腰部的特定脊髓区域。Control unit: allows fine adjustment of the electric field frequency to generate a low-frequency interfering electric field of approximately 30 Hz, deep into a specific spinal cord area in the patient's lumbar region.
操作步骤：Steps:
1.评估患者状况：通过临床评估确定慢性背痛的具体部位和原因。1. Assess the patient's condition: Determine the specific location and cause of chronic back pain through clinical assessment.
2.设定参数：根据评估结果，设定电极产生电场的频率和强度。2. Set parameters: Based on the evaluation results, set the frequency and intensity of the electric field generated by the electrodes.
3.执行治疗：连续进行30分钟的电刺激，每周两次，持续四周。3. Implementation of treatment: Continuous electrical stimulation for 30 minutes, twice a week for four weeks.
4.刺激效果：治疗后，患者的相应部位的脊髓受到30Hz电刺激，影响疼痛信号传递，产生镇痛效果。4. Stimulation effect: After treatment, the patient's spinal cord in the corresponding part is stimulated by 30Hz electricity, which affects the transmission of pain signals and produces analgesic effect.
实施例3：促进脊髓损伤后的恢复Example 3: Promoting recovery after spinal cord injury
电极配置：八个电极分布在患者受伤的脊髓区域两侧，四对电极分别生成10KHz、10KHz、10.03KHz和10.03KHz的高频电场。Electrode configuration: Eight electrodes are distributed on both sides of the patient's injured spinal cord area, and four pairs of electrodes generate high-frequency electric fields of 10KHz, 10KHz, 10.03KHz and 10.03KHz respectively.
控制单元：精确调节每对电极的频率差，产生一个或多个低频干涉电场，以目标化不同深度的脊髓结构。Control unit: precisely adjusts the frequency difference of each pair of electrodes to generate one or more low-frequency interferometric electric fields to target spinal cord structures at different depths.
操作步骤：Steps:
1.定位与评估：利用MRI确定受伤的脊髓区域，并评估损伤程度。1. Localization and assessment: MRI is used to determine the injured spinal cord area and assess the extent of the injury.
2.定制治疗方案：根据受伤部位和程度，设定刺激频率和时长。2. Customized treatment plan: Set the stimulation frequency and duration according to the injury site and severity.
3.实施刺激：根据治疗方案，开始刺激过程，每次治疗1小时，每周五次，连续两周。3. Implement stimulation: According to the treatment plan, start the stimulation process, with each treatment lasting 1 hour, five times a week, for two consecutive weeks.
4.刺激效果：刺激后，患者损伤部位及附近神经元受到同步的30Hz的刺激，产生同步活动，产生新的神经连接，促进患者损伤后运动功能的恢复。4. Stimulation effect: After stimulation, the patient's injured area and nearby neurons are stimulated synchronously at 30Hz, generating synchronous activities and new neural connections, thus promoting the recovery of the patient's motor function after injury.
实施例4：治疗脊髓性疼痛综合征Example 4: Treatment of Spinal Pain Syndrome
电极配置：两对电极，一对生成10KHz的电场，另一对生成10.005KHz的电场。Electrode configuration: Two pairs of electrodes, one pair generates an electric field of 10KHz, and the other pair generates an electric field of 10.005KHz.
控制单元：设置以产生5Hz的低频干涉电场，针对性地影响患者的痛感传递路径。Control unit: configured to generate a 5 Hz low-frequency interference electric field to specifically affect the patient's pain transmission pathway.
操作步骤：Steps:
1.详细评估：通过详细的病史采集和物理检查，确定疼痛的具体类型和区域。1. Detailed assessment: Determine the specific type and area of pain through detailed history taking and physical examination.
2.设定治疗计划：基于评估结果，定制电场参数，包括频率和治疗持续时间。2. Set treatment plan: Based on the evaluation results, customize the electric field parameters, including frequency and treatment duration.
3.进行治疗：进行每次30分钟的刺激治疗，每周三次，持续六周。3. Perform treatment: Perform stimulation treatment for 30 minutes three times a week for six weeks.
4.刺激效果：刺激后，在脊髓深部相应部位产生5Hz低频电流，影响疼痛信号的传导，产生镇痛效果。4. Stimulation effect: After stimulation, a 5Hz low-frequency current is generated in the corresponding part deep in the spinal cord, affecting the conduction of pain signals and producing analgesic effect.
本发明未述及之处均适用于现有技术。Anything not described in the present invention is applicable to the prior art.
显然，上述实施例仅仅是为清楚地说明所作的举例，而并非对实施方式的限定。对于所属领域的普通技术人员来说，在上述说明的基础上还可以做出其它不同形式的变化或变动。这里无需也无法对所有的实施方式予以穷举。而由此所引伸出的显而易见的变化或变动仍处于本发明的保护范围之中。Obviously, the above embodiments are merely examples for the purpose of clear explanation, and are not intended to limit the implementation methods. For those skilled in the art, other different forms of changes or modifications can be made based on the above description. It is not necessary and impossible to list all the implementation methods here. The obvious changes or modifications derived therefrom are still within the scope of protection of the present invention.
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410436647.2ACN118370927A (en) | 2024-04-11 | 2024-04-11 | A non-invasive spinal cord electrical stimulation method and system with precise positioning |
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410436647.2ACN118370927A (en) | 2024-04-11 | 2024-04-11 | A non-invasive spinal cord electrical stimulation method and system with precise positioning |
| Publication Number | Publication Date |
|---|---|
| CN118370927Atrue CN118370927A (en) | 2024-07-23 |
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202410436647.2APendingCN118370927A (en) | 2024-04-11 | 2024-04-11 | A non-invasive spinal cord electrical stimulation method and system with precise positioning |
| Country | Link |
|---|---|
| CN (1) | CN118370927A (en) |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN119733174A (en)* | 2025-03-05 | 2025-04-01 | 浙江大学 | Non-invasive deep time-domain interferometric electrical stimulation system and method for spinal cord rehabilitation |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN119733174A (en)* | 2025-03-05 | 2025-04-01 | 浙江大学 | Non-invasive deep time-domain interferometric electrical stimulation system and method for spinal cord rehabilitation |
| Publication | Publication Date | Title |
|---|---|---|
| AU2024202226B2 (en) | Device and method to selectively and reversibly modulate a nervous system structure to inhibit the perception of pain | |
| AU2020204156B2 (en) | Devices and methods for non-invasive capacitive electrical stimulation and their use for vagus nerve stimulation on the neck of a patient | |
| EP3212277B1 (en) | Non-invasive nerve stimulation system | |
| US10493272B1 (en) | Inferential electrical stimulation device with targeting capabilities | |
| JP2018526142A (en) | System and method for changing nerve conduction by transcutaneous direct current block | |
| CN118370927A (en) | A non-invasive spinal cord electrical stimulation method and system with precise positioning | |
| KR102814822B1 (en) | Apparatus for sleep management using device of stimulating acupoint and method for sleep management using it | |
| Balogun et al. | Effects of high-voltage galvanic stimulation of ST36 and ST37 acupuncture points on peripheral blood flow and skin temperature | |
| CN107041750B (en) | A kind of trans-skull magnetic stimulating device for backbone reduction system | |
| KR20210069255A (en) | High frequency control method for high frequency massage of delayed onset muscle soreness and high frequency treatment apparatus | |
| CN118267620A (en) | Noninvasive electrical stimulation method and system for stimulating deep spinal neurons | |
| US12208263B2 (en) | Devices and methods for non-invasive vagal nerve stimulation | |
| KR20230049931A (en) | Electrical stimulation and monitoring device and method thereof for cure disease |
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |