技术领域Technical field
本发明涉及医疗器械技术领域，尤其是涉及一种样本采集装置及方法。The present invention relates to the technical field of medical devices, and in particular, to a sample collection device and method.
背景技术Background technique
采样是对人体健康指标进行检测的第一步，安全有效的采样方式既能保证受测者在采样过程中免受感染、伤害；同时又能提升采样后检测的准确性，及早的发现身体中的病变。而对人体体液的采样(尤其是血液的采样)是人体检测中最常用的。Sampling is the first step in testing human health indicators. A safe and effective sampling method can not only ensure that the subjects are protected from infection and injury during the sampling process; at the same time, it can improve the accuracy of post-sampling testing and detect infections in the body as early as possible. of lesions. The sampling of human body fluids (especially blood sampling) is the most commonly used in human testing.
现今对人体血液的采样，主要有两种方式：静脉血和指尖血。静脉采血针的尺寸，长度在2.5-4cm，针体直径在0.5-1.5mm；在采血时需要将针扎入静脉血管中。而指尖血的采集用到的指血针，尺寸在1.5-2.5mm，刺入深度在2-3mm。这些方式在采血的同时，不可避免的会引起疼痛。指尖血在其采血过程中，需要用力挤压伤口，这对患者来说不仅带来的身体上的不舒服，并且由于其挤压的采血方式，容易造成红细胞破裂，造成溶血，影响后续检测的准确性。随着现在POCT(即时检测)能力的飞速发展，越来越多的项目需要由患者在家中完成检测，而目前的采血方式均需要在医院由专业人士完成，并且不可避免的带来疼痛，使得人们尤其是儿童往往对这样的采血方式非常的抵触。Today, there are two main ways to sample human blood: venous blood and fingertip blood. The size of the venous blood collection needle is 2.5-4cm in length and 0.5-1.5mm in diameter. When collecting blood, the needle needs to be inserted into the vein. The blood needle used to collect fingertip blood has a size of 1.5-2.5mm and a penetration depth of 2-3mm. These methods will inevitably cause pain while collecting blood. During the blood collection process, fingertip blood needs to be squeezed hard, which not only causes physical discomfort to the patient, but also can easily cause red blood cells to rupture, cause hemolysis, and affect subsequent testing due to the squeezed blood collection method. accuracy. With the rapid development of POCT (point-of-care testing) capabilities, more and more tests need to be completed by patients at home. However, the current blood collection methods need to be completed by professionals in hospitals and inevitably cause pain, making People, especially children, are often very resistant to this method of blood collection.
发明内容Contents of the invention
有鉴于此，本发明的第一个目的是提供一种样本采集装置，旨在便于实现使用者在家即可自行采集样本。In view of this, a first object of the present invention is to provide a sample collection device, which is designed to facilitate users to collect samples by themselves at home.
本发明的第二个目的是提供一种样本采集方法。The second object of the present invention is to provide a sample collection method.
为了实现上述第一个目的，本发明提供了如下方案：In order to achieve the above-mentioned first purpose, the present invention provides the following solutions:
一种样本采集装置，包括：A sample collection device including:
中空的壳体，所述壳体包括设置在其一端的采样口以及与所述采样口连通的存储池；A hollow shell, the shell includes a sampling port provided at one end thereof and a storage pool connected to the sampling port;
以及收容在所述壳体内的触发器、固定杆、驱动弹性元件及微针；And the trigger, fixed rod, driving elastic element and microneedle contained in the housing;
所述壳体对应所述触发器开设有操作孔，所述触发器具有经所述操作孔延伸至所述壳体外的按压部以及收容在所述壳体内的驱动部，所述壳体具有与所述驱动部相对且间隔设置的引导件，所述固定杆收容在所述驱动部与所述引导件之间，所述固定杆远离所述触发器的一端固定所述微针，所述微针能够从所述采样口伸出所述壳体外；The housing is provided with an operating hole corresponding to the trigger. The trigger has a pressing part extending to the outside of the housing through the operating hole and a driving part contained in the housing. The housing has a The driving part is a guide member arranged oppositely and spaced apart, the fixing rod is received between the driving part and the guide part, and the end of the fixing rod away from the trigger fixes the microneedle, and the microneedle is The needle can extend out of the housing from the sampling port;
所述驱动弹性元件套设于所述固定杆外，所述触发器经按压后挤压所述驱动弹性元件，所述驱动部与引导件配合引导所述固定杆带动所述微针经所述采样口伸出所述壳体外穿刺皮肤进行样本采集；The driving elastic element is sleeved outside the fixed rod, the trigger squeezes the driving elastic element after being pressed, and the driving part cooperates with the guide to guide the fixed rod to drive the microneedle through the The sampling port extends out of the housing to puncture the skin for sample collection;
所述存储池与所述采样口连通，用于存储经所述采样口采集的样本。The storage pool is connected to the sampling port and is used to store samples collected through the sampling port.
在一个具体的实施方案中，所述固定杆包括沿所述微针的移动方向延伸的主体部以及自所述主体部外侧向外延伸的至少一个定位杆，所述驱动弹性元件套设于所述主体部外，并设置在所述定位杆与所述触发器之间；所述样本采集装置还包括套设于所述主体部远离所述触发器一端并位于所述定位杆与所述壳体之间的复位弹性元件，所述复位弹性元件用于将所述固定杆朝所述触发器方向运动以带动所述微针远离皮肤。In a specific embodiment, the fixed rod includes a main body portion extending along the movement direction of the microneedle and at least one positioning rod extending outward from the outside of the main body portion, and the driving elastic element is sleeved on the microneedle. The sample collection device further includes an end of the main body away from the trigger and located between the positioning rod and the shell. There is a reset elastic element between the bodies, and the reset elastic element is used to move the fixing rod in the direction of the trigger to drive the microneedle away from the skin.
在另一个具体的实施方案中，所述壳体包括上盖和底座；In another specific embodiment, the housing includes an upper cover and a base;
所述上盖扣装在所述底座上；The upper cover is buckled on the base;
所述采样口开设在所述底座上，所述操作孔开设于所述上盖，所述按压部的尺寸小于与所述操作孔的孔径，且所述驱动部的尺寸大于与所述操作孔的孔径，所述按压部至少部分延伸至所述上盖外。The sampling port is opened on the base, the operating hole is opened on the upper cover, the size of the pressing part is smaller than the diameter of the operating hole, and the size of the driving part is larger than the operating hole. aperture, and the pressing portion at least partially extends outside the upper cover.
在另一个具体的实施方案中，所述引导件包括环绕所述采样口并自所述底座朝所述触发器方向延伸的支撑台以及凸设于所述支撑台侧壁的至少一个立柱；In another specific embodiment, the guide includes a support platform surrounding the sampling port and extending from the base toward the trigger direction, and at least one upright protruding from the side wall of the support platform;
所述驱动部包括与所述支撑台相对且间隔设置的环形收容部以及自所述环形收容部远离所述按压部的一端朝所述支撑台延伸的至少一个推动部；The driving part includes an annular receiving part opposite and spaced apart from the supporting platform and at least one pushing part extending from an end of the annular receiving part away from the pressing part toward the supporting platform;
所述主体部相对两端分别收容于所述支撑台与所述环形收容部，至少一个所述定位杆位于所述支撑台与所述环形收容部之间且沿所述微针的移动方向的投影延伸至所述支撑台与所述环形收容部外；Opposite ends of the main body are respectively received in the support platform and the annular receiving part, and at least one positioning rod is located between the support platform and the annular receiving part and along the movement direction of the microneedle. The projection extends outside the support platform and the annular receiving portion;
单个所述推动部位于所述单个定位杆与单个所述立柱之间，所述推动部靠近所述立柱的一侧为第一斜面，所述推动部靠近所述定位杆的一侧为第二斜面，所述第一斜面与所述第二斜面自所述环形收容部朝相互靠近的方向延伸形成所述推动部。A single pushing part is located between a single positioning rod and a single upright. The side of the pushing part close to the upright is a first slope, and the side of the pushing part close to the positioning rod is a second slope. Inclined surfaces, the first inclined surface and the second inclined surface extend from the annular receiving portion in a direction approaching each other to form the pushing portion.
在另一个具体的实施方案中，所述支撑台远离所述底座的一端部分凹陷形成有凹陷部，所述凹陷部位于所述立柱靠近所述推动部的一侧并与所述立柱间隔设置，所述推动部与所述立柱配合引导所述定位杆从所述环形收容部的端面移动至所述凹陷部。In another specific embodiment, an end portion of the support platform away from the base is recessed to form a recessed portion. The recessed portion is located on a side of the upright column close to the pushing portion and is spaced apart from the upright column. The pushing part cooperates with the upright column to guide the positioning rod to move from the end surface of the annular receiving part to the recessed part.
在另一个具体的实施方案中，至少两个所述定位杆沿着所述主体部的周向均匀间隔设置；In another specific embodiment, at least two of the positioning rods are evenly spaced along the circumference of the main body portion;
所述定位杆分别与所述推动部、所述凹陷部、及所述立柱一一对应设置。The positioning rods are respectively arranged in one-to-one correspondence with the pushing part, the recessed part, and the upright column.
在另一个具体的实施方案中，所述驱动部还包括自所述环形收容部远离所述按压部的一端朝所述支撑台延伸的限位部；In another specific embodiment, the driving part further includes a limiting part extending toward the support platform from an end of the annular receiving part away from the pressing part;
所述限位部与所述推动部间隔设置，用于限制所述定位杆受所述推动部挤压产生过度转动。The limiting part is spaced apart from the pushing part and is used to limit excessive rotation of the positioning rod due to being squeezed by the pushing part.
在另一个具体的实施方案中，所述复位弹性元件套设于所述主体部一端且收容于所述支撑台内，抵接在所述底座与所述定位杆之间。In another specific embodiment, the reset elastic element is sleeved on one end of the main body and is received in the support platform, abutting between the base and the positioning rod.
在另一个具体的实施方案中，所述底座靠近所述触发器的一侧凸设有围壁，所述围壁与所述底座共同围成所述存储池；In another specific embodiment, a surrounding wall protrudes from a side of the base close to the trigger, and the surrounding wall and the base together form the storage pool;
所述底座远离触发器的一侧围绕所述采样口凹陷形成有凹槽，所述凹槽与所述采样口连通，所述凹槽靠近所述存储池的侧壁开始有与所述存储池连通的连通孔。A groove is formed around the sampling port on the side of the base away from the trigger. The groove is connected to the sampling port. The groove starts from a side wall close to the storage pool and is connected to the storage pool. Connected vias.
在另一个具体的实施方案中，所述存储池的侧壁至少一部分为可穿刺的第一可穿刺侧壁；In another specific embodiment, at least a portion of the side wall of the storage pool is a first punctureable side wall;
所述上盖对应所述第一可穿刺侧壁的位置处设置有可穿刺的第二可穿刺侧壁，以通过所述第二可穿刺侧壁及所述第一可穿刺侧壁提取所述存储池内的样品。The upper cover is provided with a punctureable second punctureable side wall at a position corresponding to the first punctureable side wall, so that the second punctureable side wall and the first punctureable side wall can be used to extract the Samples in the storage pool.
在另一个具体的实施方案中，所述微针包括固定于所述固定杆的片状的基底以及自所述基底朝远离所述固定杆方向的针体。In another specific embodiment, the microneedle includes a sheet-shaped base fixed on the fixing rod and a needle body moving away from the fixing rod from the base.
在另一个具体的实施方案中，多个所述针体均匀间隔分布于所述基底，且与所述基底共面。In another specific embodiment, a plurality of the needles are evenly spaced on the base and are coplanar with the base.
在另一个具体的实施方案中，所述针体的长度为800微米-1300微米，宽度为150微米-500微米，厚度为20微米-50微米。In another specific embodiment, the length of the needle body is 800 microns-1300 microns, the width is 150 microns-500 microns, and the thickness is 20 microns-50 microns.
在另一个具体的实施方案中，所述微针为一片式结构，首尾相接的方式绕设于所述固定杆，首尾两端之间留有间隙，所述基底贯穿开设有定位孔。In another specific embodiment, the microneedle has a one-piece structure and is wound around the fixed rod in an end-to-end manner with a gap between the end and end. The base is provided with positioning holes through it.
根据本发明的各个实施方案可以根据需要任意组合，这些组合之后所得的实施方案也在本发明范围内，是本发明具体实施方式的一部分。The various embodiments according to the present invention can be combined arbitrarily as needed, and the embodiments obtained after these combinations are also within the scope of the present invention and are part of the specific implementation modes of the present invention.
本发明提供的样本采集装置，使用时，将样本采集装置远离触发器的那端与皮肤抵接，按压触发器的按压部，触发器挤压驱动弹性元件，驱动部与引导件配合引导固定杆带动微针经采样口伸出壳体外穿刺皮肤进行样本采集，样品经刺穿的皮肤流入存储池实现样本的采集。即本发明仅需要按压触发器即可实现样品的采集，无需专业人士进行操作，实现了使用者在家也可以自行采集。When using the sample collection device provided by the present invention, the end of the sample collection device away from the trigger is brought into contact with the skin, and the pressing part of the trigger is pressed. The trigger squeezes and drives the elastic element, and the driving part cooperates with the guide to guide the fixing rod. The microneedle is driven to extend out of the housing through the sampling port to puncture the skin for sample collection. The sample flows into the storage pool through the punctured skin to collect the sample. That is, the present invention only needs to press the trigger to collect samples, without the need for professionals to operate, and allows users to collect samples by themselves at home.
为了实现上述第二个目的，本发明提供了如下方案：In order to achieve the above second purpose, the present invention provides the following solutions:
一种样本采集方法，包括：A sample collection method including:
提供如上述中任一项所述的样本采集装置；Provide a sample collection device as described in any of the above;
按压所述触发器，所述触发器挤压驱动弹性元件，驱动部与引导件配合引导所述固定杆向靠近皮肤的方向移动，以使所述固定杆带动所述微针刺穿皮肤，样品经刺穿后的皮肤流入所述存储池。Press the trigger, and the trigger squeezes and drives the elastic element. The driving part cooperates with the guide member to guide the fixed rod to move in a direction close to the skin, so that the fixed rod drives the microneedle to pierce the skin, and the sample The punctured skin flows into the storage pool.
附图说明Description of drawings
为了更清楚地说明本发明实施例或现有技术中的技术方案，下面将对实施例或现有技术描述中所需要使用的附图作简单地介绍，显而易见地，下面描述中的附图仅仅是本发明的一些实施例，对于本领域普通技术人员来讲，在不付出新颖性劳动的前提下，还可以根据这些附图获得其他的附图。In order to explain the embodiments of the present invention or the technical solutions in the prior art more clearly, the drawings needed to be used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings in the following description are only These are some embodiments of the present invention. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without exerting any novelty effort.
图1为本发明提供的样本采集装置的爆炸结构示意图；Figure 1 is a schematic diagram of the explosion structure of the sample collection device provided by the present invention;
图2为本发明提供的样本采集装置的三维结构示意图；Figure 2 is a schematic three-dimensional structural diagram of the sample collection device provided by the present invention;
图3为本发明提供的样本采集装置的剖视结构示意图；Figure 3 is a schematic cross-sectional structural view of the sample collection device provided by the present invention;
图4a为本发明提供的底座的三维结构示意图；Figure 4a is a schematic diagram of the three-dimensional structure of the base provided by the present invention;
图4b为本发明提供的底座另一方向的三维结构示意图；Figure 4b is a schematic three-dimensional structural diagram of the base provided by the present invention in another direction;
图4c为图4a的俯视结构示意图；Figure 4c is a schematic top view of the structure of Figure 4a;
图5为本发明提供的触发器的结构示意图；Figure 5 is a schematic structural diagram of the trigger provided by the present invention;
图6为本发明提供的固定杆的结构示意图；Figure 6 is a schematic structural diagram of the fixed rod provided by the present invention;
图7为本发明提供的上盖的结构示意图；Figure 7 is a schematic structural diagram of the upper cover provided by the present invention;
图8为本发明提供的样本采集装置未安装上盖时的结构示意图；Figure 8 is a schematic structural diagram of the sample collection device provided by the present invention without an upper cover installed;
图9为本发明提供的微针的结构示意图；Figure 9 is a schematic structural diagram of the microneedle provided by the present invention;
图10为本发明提供的微针展开时的结构示意图；Figure 10 is a schematic structural diagram of the microneedle provided by the present invention when deployed;
图11为本发明提供的穿刺针的结构示意图；Figure 11 is a schematic structural diagram of the puncture needle provided by the present invention;
图12a为本发明第一种实施例提供的针尖的主视结构示意图；Figure 12a is a schematic front structural view of the needle tip provided by the first embodiment of the present invention;
图12b为本发明第二种实施例提供的针尖的主视结构示意图；Figure 12b is a schematic front structural view of the needle tip provided by the second embodiment of the present invention;
图12c为本发明第三种实施例提供针尖的主视结构示意图；Figure 12c is a schematic front structural view of a needle tip according to the third embodiment of the present invention;
图13a为本发明第一种实施例提供的针主体的横截面结构示意图；Figure 13a is a schematic cross-sectional structural view of the needle body provided by the first embodiment of the present invention;
图13b为本发明第二种实施例提供的针主体的横截面结构示意图；Figure 13b is a schematic cross-sectional structural view of the needle body provided by the second embodiment of the present invention;
图13c为本发明第三种实施例提供的针主体的横截面结构示意图；Figure 13c is a schematic cross-sectional structural view of the needle body provided by the third embodiment of the present invention;
图14a为本发明第一种实施例提供的基底围设方式的示意图；Figure 14a is a schematic diagram of a substrate surrounding method provided by the first embodiment of the present invention;
图14b为本发明第二种实施例提供的基底围设方式的示意图；Figure 14b is a schematic diagram of a substrate surrounding method provided by the second embodiment of the present invention;
图14c为本发明第三种实施例提供的基底围设方式的示意图；Figure 14c is a schematic diagram of a substrate surrounding method provided by the third embodiment of the present invention;
图14d为本发明第四种实施例提供的基底围设方式的示意图；Figure 14d is a schematic diagram of a base surrounding method provided by the fourth embodiment of the present invention;
图14e为本发明第五种实施例提供的基底围设方式的示意图；Figure 14e is a schematic diagram of a base surrounding method provided by the fifth embodiment of the present invention;
图14f为本发明第六种实施例提供的基底围设方式的示意图；Figure 14f is a schematic diagram of a substrate surrounding method provided by the sixth embodiment of the present invention;
图14g为本发明第七种实施例提供的基底围设方式的示意图；Figure 14g is a schematic diagram of a substrate surrounding method provided by the seventh embodiment of the present invention;
图14h为本发明第八种实施例提供的基底围设方式的示意图；Figure 14h is a schematic diagram of a substrate surrounding method provided by the eighth embodiment of the present invention;
图14i为本发明第九种实施例提供的基底围设方式的示意图。Figure 14i is a schematic diagram of a substrate surrounding method provided by the ninth embodiment of the present invention.
其中，图1-图14i中：Among them, in Figure 1-Figure 14i:
微针10、基底11、定位孔11a、针体12、针主体12a、针尖12b、样本采集装置100、壳体20、上盖21、操作孔21a、第二可穿刺侧壁21b、底座22、采样口22a、引导件22b、立柱22b-1、支撑台22b-2、凹陷部22c、触发器30、按压部31、驱动部32、环形收容部32a、推动部32b、第二斜面32b-2、第一斜面32b-1、限位部33、固定杆40、定位杆41、主体部42、复位弹性元件50、存储池60、第一可穿刺侧壁61、第一存储池62、第二存储池63、凹槽22d、连通孔22d-1、驱动弹性元件70。Microneedle 10, base 11, positioning hole 11a, needle body 12, needle body 12a, needle tip 12b, sample collection device 100, housing 20, upper cover 21, operating hole 21a, second punctureable side wall 21b, base 22, Sampling port 22a, guide 22b, column 22b-1, support platform 22b-2, recessed part 22c, trigger 30, pressing part 31, driving part 32, annular receiving part 32a, pushing part 32b, second slope 32b-2 , the first inclined surface 32b-1, the limiting part 33, the fixing rod 40, the positioning rod 41, the main body part 42, the reset elastic element 50, the storage pool 60, the first punctureable side wall 61, the first storage pool 62, the second Storage pool 63, groove 22d, communication hole 22d-1, and driving elastic element 70.
具体实施方式Detailed ways
下面将结合本发明实施例中的附图1-图14i，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings 1 to 14i in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Example. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts fall within the scope of protection of the present invention.
在本发明的描述中，需要理解的是，术语“上”、“下”、“顶面”、“底面”等指示的方位或位置关系为基于附图所示的方位或位置关系，仅是为了便于描述本发明和简化描述，而不是指示或暗示所指的位置或元件必须具有特定方位、以特定的方位构成和操作，因此不能理解为本发明的限制。此外，术语“第一”、“第二”仅用于描述目的，而不能理解为指示或暗示相对重要性。In the description of the present invention, it should be understood that the orientation or positional relationship indicated by the terms "upper", "lower", "top surface", "bottom surface", etc. are based on the orientation or positional relationship shown in the drawings, and are only In order to facilitate the description of the present invention and simplify the description, it is not intended to indicate or imply that the location or element referred to must have a specific orientation, be constructed and operate in a specific orientation, and therefore should not be construed as a limitation of the present invention. In addition, the terms "first" and "second" are used for descriptive purposes only and are not to be understood as indicating or implying relative importance.
结合图1-图14i所示，本发明一方面提供了一种样品采集装置100，样品采集装置100包括微针10、壳体20、触发器30、固定杆40及驱动弹性元件70，如图1-图3所示。As shown in FIGS. 1 to 14i, on one hand, the present invention provides a sample collection device 100. The sample collection device 100 includes a microneedle 10, a housing 20, a trigger 30, a fixed rod 40 and a driving elastic element 70, as shown in FIG. 1-As shown in Figure 3.
壳体20为中空的壳体，即壳体20具有内腔，触发器30、固定杆40、微针10及驱动弹性元件70均收容在壳体20内，如图3所示。The housing 20 is a hollow housing, that is, the housing 20 has an inner cavity, and the trigger 30, the fixing rod 40, the microneedle 10 and the driving elastic element 70 are all accommodated in the housing 20, as shown in FIG. 3 .
壳体20包括采样口22a及存储池60，如图4a-图4c所示，具体地，采样口22a设置在壳体20的一端，存储池60与采样口22a连通，用于存储经采样口22a采集的样品。The housing 20 includes a sampling port 22a and a storage tank 60, as shown in Figures 4a-4c. Specifically, the sampling port 22a is provided at one end of the housing 20, and the storage tank 60 is connected with the sampling port 22a for storing the samples passed through the sampling port. Samples collected on 22a.
壳体20对应触发器30开设有操作孔21a，触发器30具有按压部31和驱动部32，如图5所示，其中，按压部31经操作孔21a延伸至壳体20外，驱动部32收容在壳体20内。The housing 20 has an operating hole 21a corresponding to the trigger 30. The trigger 30 has a pressing part 31 and a driving part 32, as shown in Figure 5. The pressing part 31 extends to the outside of the housing 20 through the operating hole 21a, and the driving part 32 housed in the casing 20 .
壳体20具有引导件22b，引导件22b与驱动部32相对且间隔设置。The housing 20 has a guide 22b, and the guide 22b is opposite to and spaced apart from the driving part 32.
固定杆40收容在驱动部32与引导件22b之间，固定杆40远离触发器30的一端固定微针10，微针10能够通过采样口22a伸出壳体20外。具体地，微针10的基底11围成的环形结构套接在固定杆40的底端外壁上，且通过基底11上的连接孔11a与固定杆40紧固。The fixed rod 40 is accommodated between the driving part 32 and the guide 22b. The microneedle 10 is fixed at one end of the fixed rod 40 away from the trigger 30. The microneedle 10 can extend out of the housing 20 through the sampling port 22a. Specifically, the annular structure formed by the base 11 of the microneedle 10 is sleeved on the bottom outer wall of the fixed rod 40, and is fastened to the fixed rod 40 through the connecting hole 11a on the base 11.
驱动弹性元件70套设于固定杆40外，触发器30经按压后挤压驱动弹性元件70，驱动部32与引导件22b配合，以引导固定杆40带动微针10经采样口22a伸出壳体20外，从而穿刺皮肤进行样品采集。The driving elastic element 70 is sleeved outside the fixed rod 40. The trigger 30 squeezes the driving elastic element 70 after being pressed. The driving part 32 cooperates with the guide 22b to guide the fixed rod 40 to drive the microneedle 10 to extend out of the shell through the sampling port 22a. 20 outside the body, thereby puncturing the skin for sample collection.
初始状态下，微针10收纳于壳体20内，当采样时，微针10穿过采样口22a刺入皮肤内。In the initial state, the microneedle 10 is stored in the housing 20. When sampling, the microneedle 10 passes through the sampling port 22a and penetrates into the skin.
本发明提供的样本采集装置100，使用时，将样本采集装置100远离触发器的那端与皮肤抵接，按压触发器30的按压部31，触发器30挤压驱动弹性元件70，驱动部32与引导件22b配合引导固定杆40带动微针10经采样口22a伸出壳体20外穿刺皮肤进行样品采集，样品经刺穿的皮肤流入存储池60实现样品的采集。即本发明仅需要按压触发器30即可实现样品的采集，无需专业人士进行操作，实现了使用者在家也可以自行采集。When using the sample collection device 100 provided by the present invention, the end of the sample collection device 100 away from the trigger is brought into contact with the skin, and the pressing part 31 of the trigger 30 is pressed. The trigger 30 squeezes and drives the elastic element 70 and the driving part 32 The fixed rod 40 cooperates with the guide 22b to drive the microneedle 10 to extend out of the housing 20 through the sampling port 22a to puncture the skin for sample collection. The sample flows through the punctured skin into the storage pool 60 to collect the sample. That is to say, the present invention only needs to press the trigger 30 to collect samples, without the need for professionals to operate, so that users can collect samples by themselves at home.
在一些实施例中，固定杆40包括沿微针10的移动方向延伸的主体42以及自主体部42外侧向外延伸的至少一个定位杆41，如图6所示。定位杆41与主体部42垂直连接，当然，也可以设置定位杆41呈一定角度倾斜设置。复位弹性元件套设在主体部42外，且一端与定位杆41抵接。需要说明的是，定位杆41的个数不限于为1个，可以设置2个或者2个以上，且沿着主体部42的轴线环形均布在主体部42上，以便于对复位弹性元件50施力的均匀。可以理解地，也可以设置定位杆41不等间距环绕主体部42的轴线布置在主体部42上。In some embodiments, the fixing rod 40 includes a main body 42 extending along the moving direction of the microneedle 10 and at least one positioning rod 41 extending outward from the outside of the main body 42, as shown in FIG. 6 . The positioning rod 41 is vertically connected to the main body portion 42. Of course, the positioning rod 41 can also be arranged to be inclined at a certain angle. The reset elastic element is sleeved outside the main body 42 and has one end in contact with the positioning rod 41 . It should be noted that the number of positioning rods 41 is not limited to one. Two or more positioning rods 41 can be provided, and are evenly distributed on the main body 42 along the axis of the main body 42 to facilitate the reset of the elastic element 50 Apply force evenly. It is understood that the positioning rods 41 may also be arranged on the main body 42 at unequal intervals around the axis of the main body 42 .
驱动弹性元件70套设于主体部42并设置在定位杆41与触发器30之间，具体地，驱动弹性元件70为弹簧，需要说明的是，驱动弹性元件70不限于为弹簧，也可以是其它弹性件。The driving elastic element 70 is sleeved on the main body 42 and is arranged between the positioning rod 41 and the trigger 30. Specifically, the driving elastic element 70 is a spring. It should be noted that the driving elastic element 70 is not limited to a spring, and may also be a spring. Other elastic parts.
样本采集装置100还包括复位弹性元件50，复位弹性元件50套设于主体部42远离触发器30的一端，并位于定位杆41与壳体20之间，用于将固定杆40朝触发器30方向运动以带动微针10远离皮肤，实现触发器30的复位。如图3所示，复位弹性元件50的一端与定位杆41抵接或者连接，复位弹性元件50的另一端与壳体20的内壁的底端抵接或者连接。具体地，复位弹性元件50为弹簧，需要说明的是，复位弹性元件50不限于为弹簧，也可以是其它弹性件。The sample collection device 100 also includes a reset elastic element 50 . The reset elastic element 50 is sleeved on the end of the main body 42 away from the trigger 30 and is located between the positioning rod 41 and the housing 20 . It is used to move the fixing rod 40 toward the trigger 30 The microneedle 10 moves in a certain direction to drive the microneedle 10 away from the skin to reset the trigger 30 . As shown in FIG. 3 , one end of the return elastic element 50 is in contact with or connected to the positioning rod 41 , and the other end of the return elastic element 50 is in contact with or connected to the bottom end of the inner wall of the housing 20 . Specifically, the return elastic element 50 is a spring. It should be noted that the return elastic element 50 is not limited to a spring and can also be other elastic components.
在一些实施例中，壳体20包括上盖21和底座22，上盖21扣装在底座22上，便于壳体20的拆装。In some embodiments, the housing 20 includes an upper cover 21 and a base 22 . The upper cover 21 is buckled on the base 22 to facilitate the disassembly and assembly of the housing 20 .
采样口22a开设在底座22上，如图4a所示。操作孔21a开设在上盖21上，如图7所示。The sampling port 22a is provided on the base 22, as shown in Figure 4a. The operation hole 21a is opened in the upper cover 21, as shown in Figure 7.
按压部31的尺寸小于与操作孔21a的孔径，且驱动部32的尺寸大于与操作孔21a的孔径，使得驱动部32能够容纳于壳体20内，并在驱动弹性元件70的作用下与上盖21抵接。The size of the pressing part 31 is smaller than the diameter of the operating hole 21a, and the size of the driving part 32 is larger than the diameter of the operating hole 21a, so that the driving part 32 can be accommodated in the housing 20 and interact with the upper part under the action of the driving elastic element 70. The cover 21 is in contact.
按压部31能够在操作孔21a内滑移，且按压部31至少一部分延伸至上盖21外。The pressing part 31 can slide within the operation hole 21 a, and at least a part of the pressing part 31 extends outside the upper cover 21 .
进一步地，本发明公开了采样口22a和操作孔21a均为圆形孔，且同轴线设置。Further, the present invention discloses that both the sampling port 22a and the operating hole 21a are circular holes and are arranged coaxially.
按压部31与操作孔21a的形状相适配，使得按压部31能够沿着操作孔21a滑移，当操作孔21a为圆形孔时，按压部31对应为圆柱状或者圆筒状。为了避免按压时手指打滑，本发明公开了按压部31的顶端端面上设置有防滑花纹层或者粘贴有防滑垫等。The pressing part 31 matches the shape of the operating hole 21a, so that the pressing part 31 can slide along the operating hole 21a. When the operating hole 21a is a circular hole, the pressing part 31 is correspondingly cylindrical or cylindrical. In order to prevent fingers from slipping when pressing, the present invention discloses that the top end surface of the pressing part 31 is provided with an anti-slip pattern layer or is pasted with an anti-slip pad.
为了便于加工，驱动部32也呈圆柱状或者圆筒状，且与按压部31同轴线设置，驱动部32的外径大于按压部31的外径及操作孔21a的内径。In order to facilitate processing, the driving part 32 is also cylindrical or cylindrical and is arranged coaxially with the pressing part 31. The outer diameter of the driving part 32 is larger than the outer diameter of the pressing part 31 and the inner diameter of the operating hole 21a.
在一些实施例中，引导件22b包括支撑台22b-2和立柱22b-1，支撑台22b-2环绕采样口22a并自底座22朝触发器30方向延伸形成，立柱22b-1凸设于支撑台22b-2的侧壁，且立柱22b-1的个数至少为一个。In some embodiments, the guide 22b includes a support platform 22b-2 and a column 22b-1. The support platform 22b-2 surrounds the sampling port 22a and extends from the base 22 toward the trigger 30. The column 22b-1 is protruding from the support. The side wall of the platform 22b-2, and the number of the uprights 22b-1 is at least one.
驱动部32包括环形收容部32a及推动部32b，环形收容部32a与支撑台22b-2相对且间隔设置，推动部32b自环形收容部32a远离按压部31的一端朝支撑台22b-2延伸形成，且个数至少为一个。The driving part 32 includes an annular receiving part 32a and a pushing part 32b. The annular receiving part 32a is opposite to the supporting platform 22b-2 and is arranged at a distance. The pushing part 32b extends from an end of the annular receiving part 32a away from the pressing part 31 toward the supporting platform 22b-2. , and the number is at least one.
主体部42相对两端分别收容于支撑台22b-2与环形收容部32a，至少一个定位杆41位于支撑台22b-2与环形收容部32a之间，且定位杆41沿微针10的移动方向的投影延伸至支撑台22b-2与环形收容部32a外。支撑台22b-2起到了一个限位定位杆41的作用，避免在触发器30的驱动部32未驱动固定杆40时，固定杆40带动微针10移动，进而避免微针10的误动作。Opposite ends of the main body 42 are respectively received in the support platform 22b-2 and the annular receiving part 32a. At least one positioning rod 41 is located between the supporting platform 22b-2 and the annular receiving part 32a, and the positioning rod 41 is along the movement direction of the microneedle 10. The projection extends to the outside of the support platform 22b-2 and the annular receiving portion 32a. The support platform 22b-2 functions as a limiting positioning rod 41 to prevent the fixed rod 40 from driving the microneedle 10 to move when the driving part 32 of the trigger 30 does not drive the fixed rod 40, thereby preventing the microneedle 10 from malfunctioning.
单个推动部32b位于单个定位杆41与单个立柱22b-1之间，推动部32b靠近立柱22b-1的一侧为第一斜面32b-1，推动部32b靠近定位杆41的一侧为第二斜面32b-2，第一斜面32b-1与第二斜面32b-2自环形收容部32a朝相互靠近的方向延伸形成推动部32b，如图8所示。The single pushing part 32b is located between the single positioning rod 41 and the single column 22b-1. The side of the pushing part 32b close to the column 22b-1 is the first slope 32b-1, and the side of the pushing part 32b close to the positioning rod 41 is the second slope. The inclined surface 32b-2, the first inclined surface 32b-1 and the second inclined surface 32b-2 extend from the annular receiving part 32a in a direction approaching each other to form a pushing part 32b, as shown in FIG. 8 .
当触发器30向靠近底座22的方向移动时，立柱22b-1推动触发器30的推动部32b的第一斜面32b-1，以使触发器30转动进而带动第二斜面32b-2推动定位杆41从支撑台22b-2上脱落，使得固定杆40带动微针10刺穿皮肤进行样品采集。When the trigger 30 moves toward the base 22, the upright column 22b-1 pushes the first inclined surface 32b-1 of the pushing part 32b of the trigger 30, so that the trigger 30 rotates and then drives the second inclined surface 32b-2 to push the positioning rod. 41 falls off from the support platform 22b-2, so that the fixed rod 40 drives the microneedle 10 to pierce the skin for sample collection.
需要说明的是，采用推动部32b的第一斜面32b-1与立柱22b-1相互作用，以将触发器30的直线运动转换为转动，进而通过推动部32b的第二斜面32b-2将定位杆41从支撑台22b-2的一侧推下，从而实现了固定杆40带动微针10刺入皮肤内。It should be noted that the first inclined surface 32b-1 of the pushing part 32b interacts with the column 22b-1 to convert the linear motion of the trigger 30 into rotation, and then the second inclined surface 32b-2 of the pushing part 32b is used to position the trigger 30. The rod 41 is pushed down from one side of the support platform 22b-2, so that the fixed rod 40 drives the microneedle 10 to penetrate into the skin.
可以理解地，本发明公开的触发器30推动固定杆40运动的上述结构仅是本发明的一个具体实施方式，在实际应用中，也可以设置为其它结构，例如，固定杆40的顶端与触发器30的底端连接，固定杆40外套设弹簧，弹簧的一端与触发器30抵接，弹簧的另一端与底座抵接，且弹簧处于压缩状态，因此，使得触发器30的驱动部32的顶端与壳体20的内壁顶端抵接，进而使得固定杆40带动微针10远离皮肤；当按压触发器30时，固定杆40克服弹簧的弹性力，带动微针10刺入皮肤内。It can be understood that the above-mentioned structure of the trigger 30 pushing the fixed rod 40 to move disclosed in the present invention is only a specific embodiment of the present invention. In practical applications, it can also be configured with other structures, for example, the top of the fixed rod 40 and the trigger The bottom end of the trigger 30 is connected, and a spring is wrapped around the fixed rod 40. One end of the spring is in contact with the trigger 30, and the other end of the spring is in contact with the base, and the spring is in a compressed state. Therefore, the driving part 32 of the trigger 30 is The top end is in contact with the top end of the inner wall of the housing 20, so that the fixed rod 40 drives the microneedle 10 away from the skin; when the trigger 30 is pressed, the fixed rod 40 overcomes the elastic force of the spring and drives the microneedle 10 to penetrate into the skin.
进一步地，本发明公开了支撑台22b-2远离底座22的一端部分凹陷形成有凹陷部22c，凹陷部22c位于立柱22b-1靠近推动部32b的一侧并与立柱22b-1间隔设置，推动部32b与立柱22b-1配合引导定位杆41从收容部的端面移动至凹陷部22c。Further, the present invention discloses that the end portion of the support platform 22b-2 away from the base 22 is recessed to form a recessed portion 22c. The recessed portion 22c is located on the side of the upright column 22b-1 close to the pushing portion 32b and is spaced apart from the upright column 22b-1. The portion 32b cooperates with the upright column 22b-1 to guide the positioning rod 41 to move from the end surface of the receiving portion to the recessed portion 22c.
凹陷部22c的设置有效限位了固定杆40带动微针10刺入皮肤的深度，避免了微针10刺入皮肤过深，进而提高了使用安全性。The arrangement of the recessed portion 22c effectively limits the depth of the microneedle 10 driven by the fixed rod 40 to penetrate the skin, preventing the microneedle 10 from penetrating the skin too deeply, thus improving the safety of use.
进一步地，本发明公开了至少两个定位杆41沿着主体部42的周向均匀间隔设置，以实现支撑台22b-2对固定杆40的稳定支撑。Further, the present invention discloses that at least two positioning rods 41 are evenly spaced along the circumference of the main body 42 to achieve stable support of the fixed rod 40 by the support platform 22b-2.
定位杆41分别与推动部32b、凹陷部22c及立柱22b-1一一对应设置。The positioning rod 41 is provided in one-to-one correspondence with the pushing part 32b, the recessed part 22c and the column 22b-1.
进一步地，本发明公开了驱动部32还包括限位部33，限位部33自环形收容部32a远离按压部31的一端朝支撑台22b-2延伸而成。Furthermore, the present invention discloses that the driving part 32 further includes a limiting part 33 extending from an end of the annular receiving part 32a away from the pressing part 31 toward the supporting platform 22b-2.
限位部33与推动部32b间隔设置，用于限制定位杆41受推动部32b挤压产生过度转动。The limiting part 33 is spaced apart from the pushing part 32b, and is used to limit excessive rotation of the positioning rod 41 due to being squeezed by the pushing part 32b.
进一步地，本发明公开了位于同一立柱22b-1的两侧的限位部33及推动部32b结构相同，且关于驱动部32的中心轴对称设置。Furthermore, the present invention discloses that the limiting portion 33 and the pushing portion 32b located on both sides of the same column 22b-1 have the same structure and are symmetrically arranged with respect to the central axis of the driving portion 32.
本发明通过设置限位部33及推动部32b的结构相同，且对称设置。In the present invention, the limiting part 33 and the pushing part 32b have the same structure and are arranged symmetrically.
为了便于复位弹性元件50的定位安装，本发明公开了复位弹性元件50套设于主体部42一端且收容于支撑台22b-2内，抵接在底座与定位杆41之间。In order to facilitate the positioning and installation of the reset elastic element 50, the present invention discloses that the reset elastic element 50 is sleeved on one end of the main body 42 and received in the support platform 22b-2, and abuts between the base and the positioning rod 41.
在一些实施例中，底座靠近触发器30的一侧凸设有围壁，围壁与底座共同围成存储池60，底座22远离触发器30的一侧围绕采样口22a凹陷形成有凹槽22d，凹槽22d与采样口22a连通，凹槽22d靠近存储池60的侧壁开始有与存储池60连通的连通孔。使用时，底座22远离触发器30的一侧与皮肤表层抵接，当微针10刺入皮肤内时，溢出的样品进入凹槽22d内，沿着连通孔64进入存储池60内，实现了样品的收集。In some embodiments, a surrounding wall is protruding from the side of the base close to the trigger 30, and the surrounding wall and the base together form a storage pool 60. The side of the base 22 away from the trigger 30 is recessed to form a groove 22d around the sampling port 22a. , the groove 22d is connected with the sampling port 22a, and the groove 22d is close to the side wall of the storage tank 60 and has a communication hole connected with the storage tank 60. During use, the side of the base 22 away from the trigger 30 is in contact with the surface of the skin. When the microneedle 10 pierces the skin, the overflowed sample enters the groove 22d and enters the storage pool 60 along the communication hole 64, thus realizing Collection of samples.
为了便于将存储池60的血液取出，存储池60的侧壁至少一部分为可穿刺的第一可穿刺侧壁61，如图4c所示。具体地，第一可穿刺侧壁61为存储池60远离采样口22a的那侧壁面，由薄膜制成。In order to facilitate the removal of blood from the storage pool 60, at least a part of the side wall of the storage pool 60 is a first punctureable side wall 61, as shown in Figure 4c. Specifically, the first punctureable side wall 61 is the side wall surface of the storage tank 60 away from the sampling port 22a, and is made of a film.
如图7所示，上盖21对应第一可穿刺侧壁61的位置处设置有可穿刺的第二可穿刺侧壁21b，以通过第二可穿刺侧壁21b及第一可穿刺侧壁61提取存储池60内的样品。具体地，第二可穿刺侧壁21b也是由薄膜材料制成。As shown in FIG. 7 , the upper cover 21 is provided with a punctureable second punctureable side wall 21 b at a position corresponding to the first punctureable side wall 61 , so that the second punctureable side wall 21 b and the first punctureable side wall 61 can pass through. Samples from storage pool 60 are extracted. Specifically, the second penetrable side wall 21b is also made of film material.
进一步地，本发明公开了存储池60包括沿着远离采样口22a的方向依次设置的第一存储池62及第二存储池63。Further, the present invention discloses that the storage pool 60 includes a first storage pool 62 and a second storage pool 63 that are sequentially arranged in a direction away from the sampling port 22a.
第一存储池62的出口与第二存储池63的入口连通，沿着存储池60自与底座22连接的那端到远离底座22的那端的方向，第一存储池62的横截面小于第二存储池63的横截面，以便于进入第一存储池62的血液快速进入第二存储池63内。The outlet of the first storage pool 62 is connected with the inlet of the second storage pool 63. Along the direction of the storage pool 60 from the end connected to the base 22 to the end away from the base 22, the cross-section of the first storage pool 62 is smaller than that of the second storage pool 62. The cross-section of the storage pool 63 is such that the blood entering the first storage pool 62 can quickly enter the second storage pool 63 .
更进一步地，本发明公开了第一存储池62和第二存储池63均为矩形池，沿着远离采样口22a的方向，围壁的顶面自所述采样口朝远离底座方向倾斜延伸，即沿着远离采样口22a的方向，存储池60的横截面逐渐增大，以便于血液快速进入存储池60内。可以理解地，这里的存储池60的横截面是指存储池60沿着垂直存储池60自靠近采样口22a的那端至远离采样口22a的那端的方向的截面。Furthermore, the present invention discloses that both the first storage pool 62 and the second storage pool 63 are rectangular pools. Along the direction away from the sampling port 22a, the top surface of the surrounding wall extends obliquely from the sampling port in the direction away from the base. That is, the cross-section of the storage pool 60 gradually increases along the direction away from the sampling port 22a, so that blood can quickly enter the storage pool 60. It can be understood that the cross-section of the storage pool 60 here refers to the cross-section of the storage pool 60 along the direction of the vertical storage pool 60 from the end close to the sampling port 22a to the end far away from the sampling port 22a.
可以理解地，存储池60不限于为上述结构，也可以是其它形状的结构，例如，梯形池等。当然，为了便于储液槽22e内的样品快速进入存储池60内，可以设置负压结构，通过负压结构启动对凹槽22d内的气体抽真空，便于存储池60内的样品进入凹槽22d内。It can be understood that the storage pool 60 is not limited to the above-mentioned structure, and may also be a structure of other shapes, such as a trapezoidal pool, etc. Of course, in order to facilitate the sample in the storage tank 22e to quickly enter the storage tank 60, a negative pressure structure can be set up, and the negative pressure structure can be used to start vacuuming the gas in the groove 22d, so that the sample in the storage tank 60 can enter the groove 22d. Inside.
在一些实施例中，如图9和图10所示，微针10包括固定于固定杆40的基底11以及自基底11朝远离固定杆40方向的针体12，具体地，基底11呈片状，针体12的个数为多个，且阵列设置在基底11的底端。In some embodiments, as shown in FIGS. 9 and 10 , the microneedle 10 includes a base 11 fixed on the fixed rod 40 and a needle 12 extending from the base 11 away from the fixed rod 40 . Specifically, the base 11 is in the form of a sheet. , the number of needle bodies 12 is multiple, and the array is arranged at the bottom end of the base 11 .
微针10通过阵列的多个针体12来刺入皮肤，在满足采样量的基础上，减轻采样过程中的疼痛感。The microneedles 10 penetrate the skin through the plurality of needle bodies 12 in the array, thereby reducing pain during the sampling process on the basis of satisfying the sampling volume.
当样本采集装置100采样时，能够驱动微针10刺穿皮肤，以进行采样。When the sample collection device 100 takes a sample, the microneedle 10 can be driven to pierce the skin to perform sampling.
需要说明的是，针体12的个数能够满足预设采样量。即可以根据实际所需采样量，选择对应个数的针体12。It should be noted that the number of needle bodies 12 can meet the preset sampling volume. That is, the corresponding number of needle bodies 12 can be selected according to the actual required sampling volume.
本发明提供的微针10，相对于一体的静脉采血针及一体的指血针，本发明采用阵列的方式在基底11的底端阵列多个针体12，将针分割为多个小尺寸的针体12，通过多个针体12来刺穿皮肤，减小了刺入深度及单个针体12的横截面，进而减轻了疼痛感。即本发明实现了在满足采样量的基础上，减轻采样过程中的疼痛感。Compared with the integrated venous blood collection needle and the integrated finger blood needle, the microneedle 10 provided by the present invention adopts an array method to array multiple needle bodies 12 at the bottom end of the base 11 to divide the needle into multiple small-sized needles. The needle body 12 pierces the skin through multiple needle bodies 12, thereby reducing the penetration depth and the cross-section of a single needle body 12, thereby reducing pain. That is to say, the present invention can reduce the pain during the sampling process on the basis of satisfying the sampling volume.
需要说明的是，本文中，针体12的底端是指针体12先刺穿皮肤的一端，针体12的顶端是指针体12靠近基底11的一端。It should be noted that in this article, the bottom end of the needle body 12 is the end where the pointer body 12 first pierces the skin, and the top end of the needle body 12 is the end of the pointer body 12 close to the base 11 .
在一些实施例中，多个针体12均匀间隔分布于基底11，且与基底11共面，以便于实现针体12能够同时扎入皮肤，且均匀扎入皮肤，进一步减轻疼痛感。In some embodiments, multiple needles 12 are evenly spaced on the base 11 and are coplanar with the base 11 , so that the needles 12 can penetrate the skin at the same time and evenly, further reducing pain.
在一些实施例中，针体12的长度大于或者等于800微米，且小于或者等于1300微米，针体12的宽度大于或者等于150微米，且小于或者等于500微米，针体12的厚度大于或者等于20微米，且小于或者等于50微米。In some embodiments, the length of the needle body 12 is greater than or equal to 800 microns and less than or equal to 1300 microns, the width of the needle body 12 is greater than or equal to 150 microns and less than or equal to 500 microns, and the thickness of the needle body 12 is greater than or equal to 20 microns and less than or equal to 50 microns.
需要说明的是，针体12的长度是指针体12垂直刺入皮肤的长度，针体12的宽度是指针体12的最大宽度，针体12的厚度是指针体12的最大厚度。It should be noted that the length of the needle body 12 is the length of the needle body 12 vertically piercing the skin, the width of the needle body 12 is the maximum width of the needle body 12 , and the thickness of the needle body 12 is the maximum thickness of the needle body 12 .
相对于现有技术中的静脉采血针及指血针的尺寸，本发明中的针体12的尺寸明显减小，进而降低了穿刺时的疼痛感。Compared with the sizes of venous blood collection needles and finger blood needles in the prior art, the size of the needle body 12 in the present invention is significantly reduced, thereby reducing the pain during puncture.
在一些实施例中，如图11所示，针体12包括针主体12a和针尖12b，针主体12a的顶端与基底11连接，针主体12a的底端与针尖12b连接。可以理解地，沿着针体12的顶端到底端的方向，针主体12a和针尖12b依次设置。In some embodiments, as shown in Figure 11, the needle body 12 includes a needle body 12a and a needle tip 12b. The top end of the needle body 12a is connected to the base 11, and the bottom end of the needle body 12a is connected to the needle tip 12b. It can be understood that along the direction from the top to the bottom of the needle body 12, the needle body 12a and the needle tip 12b are arranged in sequence.
针主体12a与针尖12b的顶端的横截面相等，且针主体12a与针尖12b共面设置。The cross-sections of the top ends of the needle body 12a and the needle tip 12b are equal, and the needle body 12a and the needle tip 12b are coplanar.
为了便于针体12刺入皮肤内，本发明公开了针尖12b自针尖12b的顶端到底端的方向，横截面逐渐减小。In order to facilitate the penetration of the needle body 12 into the skin, the present invention discloses that the cross-section of the needle tip 12b gradually decreases from the top to the bottom of the needle tip 12b.
进一步地，如图13a-图13c所示，本发明公开了针主体12a为横截面为矩形、梯形或者六边形的条状体。Further, as shown in Figures 13a-13c, the present invention discloses that the needle body 12a is a strip-shaped body with a rectangular, trapezoidal or hexagonal cross-section.
需要说明的是，上述公开的针主体12a形状仅是本发明的一些具体实施方式，在实际应用中，也可以设置针主体12a为横截面为三角形或者异形等其它形状。It should be noted that the shapes of the needle body 12a disclosed above are only some specific embodiments of the present invention. In practical applications, the needle body 12a can also be configured to have a triangular cross-section or other shapes such as special shapes.
为了便于针主体12a刺入皮肤，本发明公开了针主体12a的侧壁边缘锋利。In order to facilitate the needle body 12a to penetrate the skin, the present invention discloses that the side wall edge of the needle body 12a is sharp.
如图12a-图12c所示，针尖12b呈三角状，具体地，针尖12b可以呈锐角三角形，也可以呈直角三角形。针尖12b的底端的尖角α大于或者等于20°，且小于或者等于90°，以便于刺入皮肤内。As shown in Figures 12a to 12c, the needle tip 12b is in the shape of a triangle. Specifically, the needle tip 12b can be in the shape of an acute triangle or a right triangle. The sharp angle α at the bottom end of the needle tip 12b is greater than or equal to 20° and less than or equal to 90° to facilitate penetration into the skin.
需要说明的是，针尖12b的底端的尖角α的角度范围值不限于为上述范围值，也可以设置针尖12b的尖角α角度为0°-20°之间的值。It should be noted that the angle range value of the sharp angle α at the bottom end of the needle tip 12b is not limited to the above range value, and the angle range of the sharp angle α of the needle tip 12b can also be set to a value between 0° and 20°.
此外，由于针体12呈片状，使得针体12的尺寸较小，且还能够切断毛细血管，减轻疼痛感。In addition, since the needle body 12 is in a sheet shape, the size of the needle body 12 is smaller, and it can also cut capillaries and reduce pain.
进一步地，本发明公开了针尖12b的底端的尖角的半径大于或者等于1微米，且小于或者等于50微米。Further, the present invention discloses that the radius of the sharp corner of the bottom end of the needle tip 12b is greater than or equal to 1 micron and less than or equal to 50 microns.
在一些实施例中，基底11为连续材质加工围设而成的环形结构，可以理解地，这里的环形结构是指围设在样本采集装置100的固定杆40的底端的周向的环形结构。In some embodiments, the base 11 is a ring-shaped structure surrounded by continuous material processing. It can be understood that the ring-shaped structure here refers to the circumferential ring-shaped structure surrounding the bottom end of the fixed rod 40 of the sample collection device 100 .
进一步地，如图14a-14i所示，基底11围设的环形结构呈圆环形、椭圆环形、四边形、五边形、六边形、四角星形、五角星形、六角星形或者三角形。Further, as shown in Figures 14a-14i, the annular structure surrounded by the base 11 is in the shape of a circular ring, an elliptical ring, a quadrilateral, a pentagon, a hexagon, a four-pointed star, a five-pointed star, a six-pointed star or a triangle.
具体地，四边形可以是长方形、正方形、梯形或者菱形等。Specifically, the quadrilateral may be a rectangle, a square, a trapezoid, a rhombus, etc.
需要说明的是，环形结构不限于为上述公开的形状，也可以是其它形状。It should be noted that the annular structure is not limited to the shape disclosed above, and may also be in other shapes.
在一些实施例中，针体12采用医用不锈钢、硅、陶瓷或者聚合物制成，针体12采用冲压、蚀刻、电脉冲，激光切割、线切割或者数控机床加工而成。In some embodiments, the needle body 12 is made of medical stainless steel, silicon, ceramic or polymer, and the needle body 12 is processed by stamping, etching, electric pulse, laser cutting, wire cutting or CNC machine tools.
进一步地，本发明公开了微针10为一片式结构，即针体12与基底11一体成型连接，便于加工制造。Furthermore, the present invention discloses that the microneedle 10 has a one-piece structure, that is, the needle body 12 and the base 11 are integrally connected, which facilitates processing and manufacturing.
微针10以首尾相接的方式绕设于固定杆40，首尾两端之间留有间隙，基底11贯穿开设有定位孔11a，以便于与固定杆40连接。The microneedle 10 is wound around the fixed rod 40 in an end-to-end manner with a gap between the end and the end. The base 11 is provided with a positioning hole 11a to facilitate connection with the fixed rod 40 .
本发明第二方面提供了一种样本采集方法，包括：提供如上述中任一项实施例中的样本采集装置100；按压触发器30，触发器30挤压驱动弹性元件70，驱动部32与引导件22b配合引导固定杆40靠近皮肤的方向移动，以使固定杆40带动微针10刺穿皮肤，样品经刺穿后的皮肤流入存储池60，实现了对样品的采集。A second aspect of the present invention provides a sample collection method, which includes: providing the sample collection device 100 as in any of the above embodiments; pressing the trigger 30, the trigger 30 squeezes and drives the elastic element 70, and the driving part 32 and The guide 22b cooperates with the guide fixed rod 40 to move in a direction close to the skin, so that the fixed rod 40 drives the microneedle 10 to pierce the skin, and the pierced skin of the sample flows into the storage pool 60, thereby realizing the collection of the sample.
松开触发器30，第一弹性元件50复位，驱动固定杆40带动微针10脱离皮肤。Release the trigger 30, the first elastic element 50 is reset, and the fixed rod 40 is driven to drive the microneedle 10 away from the skin.
在一些实施例中，触发器30的底端设置有推动部32b，底座22的顶端设置有立柱22b-1和支撑台22b-2，支撑台22b-2支撑定位杆41，触发器30挤压驱动弹性元件70，驱动部32与引导件22b配合引导固定杆40靠近皮肤的方向移动具体包括：触发器30下移，立柱22b-1与推动部32b的第一斜面32b-1抵接，立柱22b-1推动第一斜面32b-1，以使触发器30转动进而带动推动部32b的第二斜面32b-2推动定位杆41从支撑台22b-2上脱落，使得固定杆40带动微针10刺穿皮肤。In some embodiments, the bottom end of the trigger 30 is provided with a pushing part 32b, and the top end of the base 22 is provided with a column 22b-1 and a support platform 22b-2. The support platform 22b-2 supports the positioning rod 41, and the trigger 30 squeezes Driving the elastic element 70, the driving part 32 cooperates with the guide 22b to guide the fixed rod 40 to move in the direction close to the skin. Specifically, the trigger 30 moves downward, the upright 22b-1 contacts the first inclined surface 32b-1 of the pushing part 32b, and the upright 22b-1 pushes the first inclined surface 32b-1, so that the trigger 30 rotates and then drives the second inclined surface 32b-2 of the pushing part 32b to push the positioning rod 41 to fall off from the support platform 22b-2, so that the fixed rod 40 drives the microneedle 10 Pierce the skin.
需要说明的是，本文中表示方位的词均是以图8中的方向进行的设定，仅为了表述的方便，并不具有其它特定含义。It should be noted that the words expressing orientation in this article are all set according to the direction in Figure 8, which is only for the convenience of expression and does not have other specific meanings.
本说明书中各个实施例采用递进的方式描述，每个实施例重点说明的都是与其他实施例的不同之处，各个实施例之间相同相似部分互相参见即可。Each embodiment in this specification is described in a progressive manner. Each embodiment focuses on its differences from other embodiments. The same and similar parts between the various embodiments can be referred to each other.
对所公开的实施例的上述说明，使本领域专业技术人员能够实现或使用本发明。对这些实施例的多种修改对本领域的专业技术人员来说将是显而易见的，本文中所定义的一般原理可以在不脱离本发明的精神或范围的情况下，在其它实施例中实现。因此，本发明将不会被限制于本文所示的这些实施例，而是要符合与本文所公开的原理和新颖特点相一致的最宽的范围。The above description of the disclosed embodiments enables those skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be practiced in other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
在本说明书的描述中，参考术语“一个实施例”、“示例”、“具体示例”等的描述意指结合该实施例或示例描述的具体特征、结构、材料或者特点包含于本发明的至少一个实施例或示例中。在本说明书中，对上述术语的示意性表述不一定指的是相同的实施例或示例。而且，描述的具体特征、结构、材料或者特点可以在任何的一个或多个实施例或示例中以合适的方式结合。In the description of this specification, reference to the terms "one embodiment," "example," "specific example," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one aspect of the invention. in an embodiment or example. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
以上公开的本发明优选实施例只是用于帮助阐述本发明。优选实施例并没有详尽叙述所有的细节，也不限制该发明仅为的具体实施方式。显然，根据本说明书的内容，可作很多的修改和变化。本说明书选取并具体描述这些实施例，是为了更好地解释本发明的原理和实际应用，从而使所属技术领域技术人员能很好地理解和利用本发明。本发明仅受权利要求书及其全部范围和等效物的限制。The preferred embodiments of the invention disclosed above are only intended to help illustrate the invention. The preferred embodiments do not describe all details, nor do they limit the invention to specific implementations. Obviously, many modifications and variations are possible in light of the contents of this specification. These embodiments are selected and described in detail in this specification to better explain the principles and practical applications of the present invention, so that those skilled in the art can better understand and utilize the present invention. The invention is limited only by the claims and their full scope and equivalents.
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| CN202211053166.0ACN117653102A (en) | 2022-08-31 | 2022-08-31 | Sample collection device and method |
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| CN202211053166.0ACN117653102A (en) | 2022-08-31 | 2022-08-31 | Sample collection device and method |
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| CN214342335U (en)* | 2020-11-25 | 2021-10-08 | 德诺杰亿（北京）生物科技有限公司 | Disposable hemostix |
| CN114630619A (en)* | 2019-08-30 | 2022-06-14 | 塔索公司 | Body fluid collection device and related methods |
| CN216754451U (en)* | 2021-11-25 | 2022-06-17 | 北京瑞成医疗器械有限公司 | Blood sampling pen |
| CN114711769A (en)* | 2022-03-28 | 2022-07-08 | 爱森斯(江苏)生物科技有限公司 | Blood sampling pen |
| CN114762598A (en)* | 2021-01-15 | 2022-07-19 | 诣晟科技(天津)有限公司 | Automatic needle changing structure for multi-needle blood sampling pen and multi-needle blood sampling pen thereof |
| KR20220104916A (en)* | 2021-01-19 | 2022-07-26 | 인제대학교 산학협력단 | Pen type Self blood lancet |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102309343A (en)* | 2010-06-24 | 2012-01-11 | 希森美康株式会社 | Micropore forms device and micropore formation method |
| CN103874460A (en)* | 2011-04-29 | 2014-06-18 | 第七感生物系统有限公司 | Delivering and/or receiving fluids |
| CN114630619A (en)* | 2019-08-30 | 2022-06-14 | 塔索公司 | Body fluid collection device and related methods |
| CN214342335U (en)* | 2020-11-25 | 2021-10-08 | 德诺杰亿（北京）生物科技有限公司 | Disposable hemostix |
| CN114762598A (en)* | 2021-01-15 | 2022-07-19 | 诣晟科技(天津)有限公司 | Automatic needle changing structure for multi-needle blood sampling pen and multi-needle blood sampling pen thereof |
| KR20220104916A (en)* | 2021-01-19 | 2022-07-26 | 인제대학교 산학협력단 | Pen type Self blood lancet |
| CN113080963A (en)* | 2021-04-14 | 2021-07-09 | 深圳市华云智能健康有限公司 | High-efficient painless blood sampling device of centre gripping formula annular micropin sword tesla valve |
| CN216754451U (en)* | 2021-11-25 | 2022-06-17 | 北京瑞成医疗器械有限公司 | Blood sampling pen |
| CN114711769A (en)* | 2022-03-28 | 2022-07-08 | 爱森斯(江苏)生物科技有限公司 | Blood sampling pen |
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| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |