技术领域Technical field
本发明涉及医疗器械技术领域，特别涉及一种肝癌栓塞术后股动脉血栓超声消融导管。The invention relates to the technical field of medical devices, and in particular to an ultrasonic ablation catheter for femoral artery thrombus after liver cancer embolization.
背景技术Background technique
肝癌栓塞是一种新颖的肝癌治疗方式，属于微创治疗方式，其通过肝动脉，把栓塞剂以及化疗药物打到肝癌细胞里，让肝癌细胞缺血坏死，达到治疗肝癌目的。股动静脉血栓是肝癌栓塞术后常见的并发症，这是因为肝癌栓塞术后血液处于高凝状态容易，血液极易在下肢动静脉血液流动较慢的区域形成血栓。Liver cancer embolization is a novel treatment method for liver cancer. It is a minimally invasive treatment method. It delivers embolic agents and chemotherapy drugs into liver cancer cells through the hepatic artery, causing ischemic necrosis of liver cancer cells to achieve the purpose of treating liver cancer. Femoral artery and vein thrombosis is a common complication after liver cancer embolization. This is because blood is prone to hypercoagulability after liver cancer embolization, and blood can easily form thrombosis in areas with slow arterial and venous blood flow in the lower limbs.
在肝癌栓塞术应积极预防下肢股动静脉血栓的形成，而在血栓形成后应积极予以治疗，防止下肢缺血性坏死而影响下肢的正常活动功能。血栓的治疗方式包括药物溶栓和超声溶栓，药物溶栓是利用溶栓导管，将溶栓药物定向注入血管发生血栓的部位是血栓溶解或软化；超声溶栓包括体外超声溶栓和体内超声溶栓两种方式，体外超声溶栓多用以治疗体表性血栓，而体内超声溶栓通过溶栓导管的介入对血栓部位直接进行溶栓。经研究发现，离体后的血栓在超声和药物共同的作用下，血栓的破碎程度相较于单独使用超声或单独使用药物溶栓下血栓的破碎程度更高，也就是药物联合超声溶栓的方式对血栓的治疗效果更好。During liver cancer embolization, the formation of femoral artery and vein thrombosis in the lower limbs should be actively prevented, and thrombosis should be actively treated to prevent ischemic necrosis of the lower limbs from affecting the normal activities of the lower limbs. Treatment methods for thrombosis include drug thrombolysis and ultrasonic thrombolysis. Drug thrombolysis uses a thrombolytic catheter to inject thrombolytic drugs into the blood vessel where the thrombus occurs to dissolve or soften the thrombus. Ultrasonic thrombolysis includes in vitro ultrasound thrombolysis and in vivo ultrasound. There are two methods of thrombolysis. Extracorporeal ultrasonic thrombolysis is mostly used to treat surface thrombi, while in vivo ultrasonic thrombolysis directly dissolves thrombosis at the thrombus site through the intervention of a thrombolysis catheter. Studies have found that the degree of fragmentation of isolated thrombus under the combined action of ultrasound and drugs is higher than that caused by ultrasound alone or drug thrombolysis alone. That is, the effect of drugs combined with ultrasound thrombolysis is This method is more effective in treating blood clots.
在相关技术中，会采用超声辅助增强药物溶栓效果，一般是先通过溶栓导管将溶栓药物递送到血栓阻塞部位，然后撤出溶栓导管，再单独通过超声能量传输系统到达病变部位，以超声提升溶栓效果。但是，由于向病变部位推送溶栓药物的过程和后期应用超声增强溶栓效果是单独控制不同器械进行的，药物溶栓和超声溶栓不同步，利用超声增强溶栓药物溶栓和缓解血栓形成上的效果不佳，溶栓效果任然有待提升；且由于需要更换设备，会延长手术时长，导致出血风险高。In related technologies, ultrasound is used to assist in enhancing the thrombolytic effect of drugs. Generally, thrombolytic drugs are first delivered to the site of thrombus obstruction through a thrombolytic catheter, and then the thrombolytic catheter is withdrawn, and then the diseased site is reached through the ultrasonic energy transmission system alone. Use ultrasound to enhance thrombolysis effect. However, since the process of pushing thrombolytic drugs to the lesion and the later application of ultrasound-enhanced thrombolysis are controlled by different devices, drug thrombolysis and ultrasound thrombolysis are not synchronized. The use of ultrasound-enhanced thrombolytic drugs to dissolve thrombosis and relieve thrombosis The effect is not good, and the thrombolytic effect still needs to be improved; and because the equipment needs to be replaced, the operation time will be extended, resulting in a high risk of bleeding.
发明内容Contents of the invention
本发明的主要目的是提供一种肝癌栓塞术后股动脉血栓超声消融导管，旨在药物溶栓和超声溶栓可以同步进行，提升溶栓药物的效果，同时缩短手术时长以降低出血风险。The main purpose of the present invention is to provide an ultrasonic ablation catheter for femoral artery thrombus after liver cancer embolization, which aims to synchronize drug thrombolysis and ultrasonic thrombolysis, improve the effect of thrombolytic drugs, and shorten the operation time to reduce the risk of bleeding.
为实现上述目的，本发明提出的肝癌栓塞术后股动脉血栓超声消融导管，包括：In order to achieve the above object, the femoral artery thrombus ultrasonic ablation catheter after liver cancer embolization proposed by the present invention includes:
溶栓套管，所述溶栓套管的一端设有转换接头，所述转换接头上固定有溶栓药物注入接口和冷却液注入接口，所述溶栓套管的另一端设有定位导向部，所述定位导向部的内腔与所述溶栓套管的内腔连通，所述溶栓套管开设有药液出射孔组；和Thrombolysis casing, one end of the thrombolysis casing is provided with a conversion joint, a thrombolytic drug injection interface and a coolant injection interface are fixed on the conversion joint, and the other end of the thrombolysis casing is provided with a positioning guide part , the inner cavity of the positioning guide part is connected with the inner cavity of the thrombolytic sleeve, and the thrombolytic sleeve is provided with a medical liquid outlet hole group; and
超声管，所述超声管的一端形成有定位凸起，所述超声管穿过所述转换接头插设于所述溶栓套管，且所述定位凸起位于所述定位导向部的内腔，所述超声管的内腔设有超声波换能器。Ultrasonic tube, one end of the ultrasonic tube is formed with a positioning protrusion, the ultrasonic tube is inserted into the thrombolysis cannula through the conversion joint, and the positioning protrusion is located in the inner cavity of the positioning guide part , the inner cavity of the ultrasonic tube is provided with an ultrasonic transducer.
可选地，所述超声管靠近所述定位凸起的一端的内腔设有多个间隔分布的所述超声波换能器，所述超声管远离所述定位凸起的一端设有驱动接头，所述驱动接头通过正极导线和负极导线与各所述超声波换能器电连接；Optionally, the inner cavity of the end of the ultrasonic tube close to the positioning protrusion is provided with a plurality of ultrasonic transducers distributed at intervals, and the end of the ultrasonic tube away from the positioning protrusion is provided with a driving joint, The driving connector is electrically connected to each of the ultrasonic transducers through a positive wire and a negative wire;
其中，多个所述超声波换能器形成超声工作区间，所述药液出射孔组对应所述超声工作区间设置。Wherein, a plurality of the ultrasonic transducers form an ultrasonic working section, and the medical liquid outlet group is arranged corresponding to the ultrasonic working section.
可选地，所述超声波换能器包括压电陶瓷片、第一金属片、第二金属片和预紧螺栓，所述第一金属片和所述第二金属片分别设置于所述压电陶瓷片的两端，所述预紧螺栓依次穿设于所述第一金属片、所述压电陶瓷片以及所述第二金属片；Optionally, the ultrasonic transducer includes a piezoelectric ceramic sheet, a first metal sheet, a second metal sheet and a pre-tightening bolt, and the first metal sheet and the second metal sheet are respectively arranged on the piezoelectric At both ends of the ceramic sheet, the pre-tightening bolts are inserted through the first metal sheet, the piezoelectric ceramic sheet and the second metal sheet in sequence;
其中，所述第一金属片与所述正极导线电连接，所述第二金属片与所述负极导线电连接。Wherein, the first metal piece is electrically connected to the positive electrode wire, and the second metal piece is electrically connected to the negative electrode wire.
可选地，所述超声管的管壁向外凸起形成多个超声工作部，所述超声工作部呈圆筒状，所述超声工作部的外径与所述溶栓套管内腔的内径相等；Optionally, the wall of the ultrasonic tube protrudes outward to form a plurality of ultrasonic working parts, the ultrasonic working part is cylindrical, and the outer diameter of the ultrasonic working part is equal to the inner diameter of the thrombolysis cannula lumen. equal;
其中，每一所述超声波换能器设于一所述超声工作部内。Wherein, each of the ultrasonic transducers is provided in one of the ultrasonic working parts.
可选地，所述溶栓套管包括药物释放导管，所述转换接头设于所述药物释放导管的一端，所述定位导向部设于所述药物释放导管的另一端，所述定位导向部的内腔与所述药物释放导管的内腔连通；Optionally, the thrombolysis cannula includes a drug release catheter, the conversion joint is provided at one end of the drug release catheter, the positioning guide is provided at the other end of the drug release catheter, the positioning guide The inner lumen is connected with the inner lumen of the drug release catheter;
所述药物释放导管靠近所述定位导向部的一端设有所述药液出射孔组，所述药液出射孔组包括多个沿所述药物释放导管的轴向方向线性分布的药液出射孔。One end of the drug release conduit close to the positioning guide is provided with the medical liquid outlet group. The medical liquid outlet group includes a plurality of medical liquid outlet holes linearly distributed along the axial direction of the drug release conduit. .
可选地，所述药物释放导管的管壁开设有冷却通道和药液注射通道，所述冷却通道和所述药液注射通道均沿所述药物释放导管的轴向延伸设置；Optionally, the tube wall of the drug release conduit is provided with a cooling channel and a medical liquid injection channel, and both the cooling channel and the medical liquid injection channel are arranged along the axial extension of the drug release conduit;
所述冷却通道设有多个，多个所述冷却通道沿所述药物释放导管的周向间隔分布；There are multiple cooling channels, and the plurality of cooling channels are distributed at intervals along the circumference of the drug release conduit;
所述药液注射通道设有多个，每一所述药液注射通道设于相邻的两个所述冷却通道之间；There are multiple medical liquid injection channels, and each medical liquid injection channel is provided between two adjacent cooling channels;
所述药液出射孔组的数量与所述药液注射通道的数量相等，每一所述药液出射孔组的多个所述药液出射孔均与一所述药液注射通道连通。The number of the medical liquid outlet groups is equal to the number of the medical liquid injection channels, and the plurality of medical liquid outlet holes in each medical liquid outlet group are connected to one of the medical liquid injection channels.
可选地，所述肝癌栓塞术后股动脉血栓超声消融导管还包括压力传感器，所述转换接头上固定有导线引出接头，所述压力传感器固定设于所述定位导向部上，所述压力传感器的导线穿过所述导线引出接头。Optionally, the femoral artery thrombus ultrasonic ablation catheter after liver cancer embolization also includes a pressure sensor, a wire lead-out joint is fixed on the conversion joint, the pressure sensor is fixed on the positioning guide part, and the pressure sensor of wires pass through the wire outlet connector.
可选地，所述药物释放导管的管壁还开设有传感器工作通道，所述传感器工作通道设于相邻的两个所述冷却通道之间，所述传感器工作通道贯穿所述药物释放导管和所述定位导向部，所述压力传感器设于所述传感器工作通道的通道口，并密封所述传感器工作通道，所述压力传感器的导线穿过所述传感器工作通道。Optionally, the wall of the drug release conduit is also provided with a sensor working channel, the sensor working channel is provided between two adjacent cooling channels, and the sensor working channel runs through the drug release conduit and In the positioning guide part, the pressure sensor is located at the channel opening of the sensor working channel and seals the sensor working channel, and the wire of the pressure sensor passes through the sensor working channel.
可选地，所述转换接头包括药液分流接头和冷却液分流接头，所述药液分流接头和所述冷却液分流接头均为内部中空的环形圆柱结构；Optionally, the conversion joint includes a medical liquid shunt joint and a cooling liquid shunt joint, both of which are annular cylindrical structures with hollow interiors;
所述冷却液分流接头的一端设有多个冷却液分流插头，多个所述冷却液分流插头均与所述冷却液分流接头的内腔连通，每一所述冷却液分流插头插接于一所述冷却通道，所述冷却液分流接头的另一端设有所述冷却液注入接口，所述冷却液注入接口与所述冷却液分流接头的内腔连通，所述冷却液分流接头开设有多个过孔；One end of the coolant shunt joint is provided with a plurality of coolant shunt plugs. The plurality of coolant shunt plugs are connected to the inner cavity of the coolant shunt joint. Each of the coolant shunt plugs is plugged into a In the cooling channel, the other end of the coolant diverter joint is provided with the coolant injection interface, the coolant injection interface is connected with the inner cavity of the coolant diverter joint, and the coolant diverter joint has multiple openings. via hole;
所述药液分流接头的一端设有传感器护管和多个药液分流插头，所述传感器护管穿过一所述过孔插接于所述传感器工作通道，多个所述药液分流插头均与所述药液分流接头的内腔连通，每一所述药液分流插头穿过一所述过孔插接于一所述药液注射通道，所述药液分流接头的另一端设有所述溶栓药物注入接口和所述导线引出接头，所述溶栓药物注入接口与所述药液分流接头的内腔连通，所述导线引出接头与所述传感器护管连通，所述药液分流接头开设有冷却液注入接口孔，所述冷却液注入接口穿设于所述冷却液注入接口孔。One end of the medical liquid shunt joint is provided with a sensor protective tube and a plurality of medical liquid shunt plugs. The sensor protective tube passes through one of the through holes and is inserted into the sensor working channel. A plurality of the medical liquid shunt plugs They are all connected to the inner cavity of the medical liquid shunt connector. Each of the medical liquid shunt plugs passes through one of the through holes and is inserted into one of the medical liquid injection channels. The other end of the medical liquid shunt connector is provided with The thrombolytic drug injection interface and the wire lead-out joint, the thrombolytic drug injection interface is connected to the inner cavity of the medicine liquid shunt joint, the wire lead-out connector is connected to the sensor protective tube, and the medicine liquid The shunt joint is provided with a coolant injection interface hole, and the coolant injection interface is passed through the coolant injection interface hole.
可选地，所述溶栓套管靠近所述定位导向部的一端设有金属定位圈，所述金属定位圈用于检测所述溶栓套管的位置。Optionally, a metal positioning ring is provided at one end of the thrombolysis cannula close to the positioning guide portion, and the metal positioning ring is used to detect the position of the thrombolysis cannula.
在本发明技术方案中，溶栓套管的定位导向部可沿预设的介入导丝到达血栓形成位置，然后将超声管插入溶栓套管内，直至定位凸起位于定位导向部的内腔，之后通过溶栓药物注入接口和药液出射孔组将溶栓药物作用于血栓。同时通过超声波换能器形成超声波，超声波具有机械效应和空化效应，机械效应可以破坏血栓的结构，将血栓由紧密的纤维蛋白结构变为松散的纤维蛋白结构，有利于溶栓药物的渗透；空化效应可以使栓塞部位大量微气泡瞬间破裂，破坏血栓表面结构以溶解血栓。以此药物溶栓和超声溶栓可以同步进行，提升溶栓药物的效果，同时缩短手术时长以降低出血风险。此外，低频高能超声在工作是会产生大量热量，通过冷却液注入接口可以注入冷却液对溶栓套管进行降温，防止溶栓套管温度过高导致正常流动的血液发生变性。In the technical solution of the present invention, the positioning guide part of the thrombolysis cannula can reach the thrombosis position along the preset interventional guide wire, and then the ultrasonic tube is inserted into the thrombolysis cannula until the positioning protrusion is located in the inner cavity of the positioning guide part. Then, the thrombolytic drug acts on the thrombus through the thrombolytic drug injection interface and the liquid outlet perforation group. At the same time, ultrasonic waves are formed through the ultrasonic transducer. Ultrasonic waves have mechanical effects and cavitation effects. The mechanical effects can destroy the structure of the thrombus and change the thrombus from a tight fibrin structure to a loose fibrin structure, which is conducive to the penetration of thrombolytic drugs; The cavitation effect can instantly burst a large number of microbubbles at the embolization site, destroying the surface structure of the thrombus to dissolve the thrombus. With this method, drug thrombolysis and ultrasound thrombolysis can be performed simultaneously to improve the effect of thrombolytic drugs and shorten the duration of the operation to reduce the risk of bleeding. In addition, low-frequency high-energy ultrasound will generate a lot of heat when working. Coolant can be injected through the coolant injection interface to cool down the thrombolysis cannula to prevent the denaturation of normal flowing blood caused by excessive temperature of the thrombolysis cannula.
附图说明Description of drawings
为了更清楚地说明本发明实施例或现有技术中的技术方案，下面将对实施例或现有技术描述中所需要使用的附图作简单地介绍，显而易见地，下面描述中的附图仅仅是本发明的一些实施例，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图示出的结构获得其他的附图。In order to explain the embodiments of the present invention or the technical solutions in the prior art more clearly, the drawings needed to be used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings in the following description are only These are some embodiments of the present invention. For those of ordinary skill in the art, other drawings can be obtained based on the structures shown in these drawings without exerting creative efforts.
图1为本发明所提供的肝癌栓塞术后股动脉血栓超声消融导管的一实施例的立体结构示意图；Figure 1 is a schematic three-dimensional structural diagram of an embodiment of a femoral artery thrombus ultrasonic ablation catheter after liver cancer embolization provided by the present invention;
图2为图1的结构分解示意图；Figure 2 is an exploded schematic diagram of the structure of Figure 1;
图3为图2中A-A截面的剖视结构示意图；Figure 3 is a schematic cross-sectional structural diagram of the A-A section in Figure 2;
图4为超声管的剖面结构示意图；Figure 4 is a schematic diagram of the cross-sectional structure of the ultrasonic tube;
图5为图4中B处的放大示意图；Figure 5 is an enlarged schematic diagram of position B in Figure 4;
图6为转换接头的结构示意图；Figure 6 is a schematic structural diagram of the conversion joint;
图7为转换接头的结构分解示意图。Figure 7 is an exploded schematic diagram of the structure of the conversion joint.
附图标号说明：Explanation of reference numbers:
本发明目的的实现、功能特点及优点将结合实施例，参照附图做进一步说明。The realization of the purpose, functional features and advantages of the present invention will be further described with reference to the embodiments and the accompanying drawings.
具体实施方式Detailed ways
下面将结合本发明实施例中的附图，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明的一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without making creative efforts fall within the scope of protection of the present invention.
需要说明，本发明实施例中所有方向性指示(诸如上、下、左、右、前、后……)仅用于解释在某一特定姿态(如附图所示)下各部件之间的相对位置关系、运动情况等，如果该特定姿态发生改变时，则该方向性指示也相应地随之改变。It should be noted that all directional indications (such as up, down, left, right, front, back...) in the embodiment of the present invention are only used to explain the relationship between components in a specific posture (as shown in the drawings). Relative positional relationship, movement conditions, etc., if the specific posture changes, the directional indication will also change accordingly.
另外，在本发明中涉及“第一”、“第二”等的描述仅用于描述目的，而不能理解为指示或暗示其相对重要性或者隐含指明所指示的技术特征的数量。由此，限定有“第一”、“第二”的特征可以明示或者隐含地包括至少一个该特征。另外，各个实施例之间的技术方案可以相互结合，但是必须是以本领域普通技术人员能够实现为基础，当技术方案的结合出现相互矛盾或无法实现时应当认为这种技术方案的结合不存在，也不在本发明要求的保护范围之内。In addition, descriptions involving "first", "second", etc. in the present invention are for descriptive purposes only and cannot be understood as indicating or implying their relative importance or implicitly indicating the number of indicated technical features. Therefore, features defined as "first" and "second" may explicitly or implicitly include at least one of these features. In addition, the technical solutions in various embodiments can be combined with each other, but it must be based on the realization by those of ordinary skill in the art. When the combination of technical solutions is contradictory or cannot be realized, it should be considered that such a combination of technical solutions does not exist. , nor within the protection scope required by the present invention.
肝癌栓塞是一种新颖的肝癌治疗方式，属于微创治疗方式，其通过肝动脉，把栓塞剂以及化疗药物打到肝癌细胞里，让肝癌细胞缺血坏死，达到治疗肝癌目的。股动静脉血栓是肝癌栓塞术后常见的并发症，这是因为肝癌栓塞术后血液处于高凝状态容易，血液极易在下肢动静脉血液流动较慢的区域形成血栓。Liver cancer embolization is a novel treatment method for liver cancer. It is a minimally invasive treatment method. It delivers embolic agents and chemotherapy drugs into liver cancer cells through the hepatic artery, causing ischemic necrosis of liver cancer cells to achieve the purpose of treating liver cancer. Femoral artery and vein thrombosis is a common complication after liver cancer embolization. This is because blood is prone to hypercoagulability after liver cancer embolization, and blood can easily form thrombosis in areas with slow arterial and venous blood flow in the lower limbs.
在肝癌栓塞术应积极预防下肢股动静脉血栓的形成，而在血栓形成后应积极予以治疗，防止下肢缺血性坏死而影响下肢的正常活动功能。血栓的治疗方式包括药物溶栓和超声溶栓，药物溶栓是利用溶栓导管，将溶栓药物定向注入血管发生血栓的部位是血栓溶解或软化；超声溶栓包括体外超声溶栓和体内超声溶栓两种方式，体外超声溶栓多用以治疗体表性血栓，而体内超声溶栓通过溶栓导管的介入对血栓部位直接进行溶栓。经研究发现，离体后的血栓在超声和药物共同的作用下，血栓的破碎程度相较于单独使用超声或单独使用药物溶栓下血栓的破碎程度更高，也就是药物联合超声溶栓的方式对血栓的治疗效果更好。During liver cancer embolization, the formation of femoral artery and vein thrombosis in the lower limbs should be actively prevented, and thrombosis should be actively treated to prevent ischemic necrosis of the lower limbs from affecting the normal activities of the lower limbs. Treatment methods for thrombosis include drug thrombolysis and ultrasonic thrombolysis. Drug thrombolysis uses a thrombolytic catheter to inject thrombolytic drugs into the blood vessel where the thrombus occurs to dissolve or soften the thrombus. Ultrasonic thrombolysis includes in vitro ultrasound thrombolysis and in vivo ultrasound. There are two methods of thrombolysis. Extracorporeal ultrasonic thrombolysis is mostly used to treat surface thrombi, while in vivo ultrasonic thrombolysis directly dissolves thrombosis at the thrombus site through the intervention of a thrombolysis catheter. Studies have found that the degree of fragmentation of isolated thrombus under the combined action of ultrasound and drugs is higher than that caused by ultrasound alone or drug thrombolysis alone. That is, the effect of drugs combined with ultrasound thrombolysis is This method is more effective in treating blood clots.
在相关技术中，会采用超声辅助增强药物溶栓效果，一般是先通过溶栓导管将溶栓药物递送到血栓阻塞部位，然后撤出溶栓导管，再单独通过超声能量传输系统到达病变部位，以超声提升溶栓效果。但是，由于向病变部位推送溶栓药物的过程和后期应用超声增强溶栓效果是单独控制不同器械进行的，药物溶栓和超声溶栓不同步，利用超声增强溶栓药物溶栓和缓解血栓形成上的效果不佳，溶栓效果任然有待提升；且由于需要更换设备，会延长手术时长，导致出血风险高。In related technologies, ultrasound is used to assist in enhancing the thrombolytic effect of drugs. Generally, thrombolytic drugs are first delivered to the site of thrombus obstruction through a thrombolytic catheter, and then the thrombolytic catheter is withdrawn, and then the diseased site is reached through the ultrasonic energy transmission system alone. Use ultrasound to enhance thrombolysis effect. However, since the process of pushing thrombolytic drugs to the lesion and the later application of ultrasound-enhanced thrombolysis are controlled by different devices, drug thrombolysis and ultrasound thrombolysis are not synchronized. The use of ultrasound-enhanced thrombolytic drugs to dissolve thrombosis and relieve thrombosis The effect is not good, and the thrombolytic effect still needs to be improved; and because the equipment needs to be replaced, the operation time will be extended, resulting in a high risk of bleeding.
为解决上述问题，本发明提出了一种肝癌栓塞术后股动脉血栓超声消融导管，旨在提供一种，图1至图7为本发明所提供的肝癌栓塞术后股动脉血栓超声消融导管的一实施例。In order to solve the above problems, the present invention proposes an ultrasonic ablation catheter for femoral artery thrombus after liver cancer embolization, aiming to provide an ultrasonic ablation catheter for femoral artery thrombus after liver cancer embolization. One embodiment.
请参考图1至图7，本发明提出一种肝癌栓塞术后股动脉血栓超声消融导管1000，包括溶栓套管1和超声管2，溶栓套管1的一端设有转换接头3，转换接头3上固定有溶栓药物注入接口31和冷却液注入接口32，溶栓套管1的另一端设有定位导向部12，定位导向部12的内腔与溶栓套管1的内腔连通，溶栓套管1开设有药液出射孔组；超声管2的一端形成有定位凸起21，超声管2穿过转换接头3插设于溶栓套管1，且定位凸起21位于定位导向部12的内腔，超声管2的内腔设有超声波换能器22。Please refer to Figures 1 to 7. The present invention proposes a femoral artery thrombus ultrasonic ablation catheter 1000 after liver cancer embolization, including a thrombolytic cannula 1 and an ultrasonic tube 2. One end of the thrombolytic cannula 1 is provided with a conversion joint 3. A thrombolytic drug injection interface 31 and a coolant injection interface 32 are fixed on the joint 3. The other end of the thrombolysis sleeve 1 is provided with a positioning guide 12, and the inner cavity of the positioning guide 12 is connected with the inner cavity of the thrombolysis sleeve 1. , the thrombolysis casing 1 is provided with a medical solution exit hole group; a positioning protrusion 21 is formed on one end of the ultrasonic tube 2, the ultrasonic tube 2 is inserted into the thrombolysis casing 1 through the conversion joint 3, and the positioning protrusion 21 is located at the positioning The inner cavity of the guide part 12 and the inner cavity of the ultrasonic tube 2 are provided with an ultrasonic transducer 22 .
在本实施例中，溶栓套管1的定位导向部12可沿预设的介入导丝到达血栓形成位置，然后将超声管2插入溶栓套管1内，直至定位凸起21位于定位导向部12的内腔，之后通过溶栓药物注入接口31和药液出射孔组将溶栓药物作用于血栓。同时通过超声波换能器22形成超声波，超声波具有机械效应和空化效应，机械效应可以破坏血栓的结构，将血栓由紧密的纤维蛋白结构变为松散的纤维蛋白结构，有利于溶栓药物的渗透；空化效应可以使栓塞部位大量微气泡瞬间破裂，破坏血栓表面结构以溶解血栓。以此药物溶栓和超声溶栓可以同步进行，提升溶栓药物的效果，同时缩短手术时长以降低出血风险。此外，低频高能超声在工作是会产生大量热量，通过冷却液注入接口32可以注入冷却液对溶栓套管1进行降温，防止溶栓套管1温度过高导致正常流动的血液发生变性。In this embodiment, the positioning guide 12 of the thrombolysis cannula 1 can reach the thrombosis position along the preset interventional guide wire, and then the ultrasound tube 2 is inserted into the thrombolysis cannula 1 until the positioning protrusion 21 is located on the positioning guide. The inner cavity of the part 12, and then the thrombolytic drug acts on the thrombus through the thrombolytic drug injection interface 31 and the medical solution outlet group. At the same time, ultrasonic waves are formed by the ultrasonic transducer 22. Ultrasonic waves have mechanical effects and cavitation effects. The mechanical effects can destroy the structure of the thrombus and change the thrombus from a tight fibrin structure to a loose fibrin structure, which is conducive to the penetration of thrombolytic drugs. ; The cavitation effect can instantly burst a large number of microbubbles at the embolization site, destroying the surface structure of the thrombus to dissolve the thrombus. With this method, drug thrombolysis and ultrasound thrombolysis can be performed simultaneously to improve the effect of thrombolytic drugs and shorten the duration of the operation to reduce the risk of bleeding. In addition, low-frequency high-energy ultrasound will generate a large amount of heat when working. Coolant can be injected through the coolant injection interface 32 to cool down the thrombolysis cannula 1 to prevent the thrombolysis cannula 1 from being overheated and causing denaturation of normal flowing blood.
定位导向部12呈锥形筒状结构，可以便于引导溶栓套管1插入至血栓形成位置，此外在可以和超声管2的定位凸起21配合以限制超声管2相对于溶栓套管1的位置。The positioning guide 12 has a tapered cylindrical structure, which can easily guide the insertion of the thrombolysis cannula 1 to the position of thrombus formation. In addition, it can cooperate with the positioning protrusion 21 of the ultrasonic tube 2 to limit the positioning of the ultrasonic tube 2 relative to the thrombolysis cannula 1 s position.
为了提高溶栓效果，在本发明的一实施例中，超声管2靠近定位凸起21的一端的内腔设有多个间隔分布的超声波换能器22，超声管2远离定位凸起21的一端设有驱动接头23，驱动接头23通过正极导线24和负极导线25与各超声波换能器22电连接，多个超声波换能器22等间距设置，可以在多个位置形成超声波，通过超声波能量来促使血栓溶解或软化。其中，多个超声波换能器22形成超声工作区间，药液出射孔组对应超声工作区间设置，在超声工作区间内，超声管2形成超声振动，使得从药液出射孔组排出的溶栓药液能在超声振动下雾化形成更小的药雾，药雾能更好的渗透至血栓内，提高溶栓效果。In order to improve the thrombolysis effect, in one embodiment of the present invention, the inner cavity of one end of the ultrasonic tube 2 close to the positioning protrusion 21 is provided with a plurality of ultrasonic transducers 22 distributed at intervals, and the end of the ultrasonic tube 2 away from the positioning protrusion 21 is One end is provided with a driving connector 23. The driving connector 23 is electrically connected to each ultrasonic transducer 22 through a positive wire 24 and a negative wire 25. Multiple ultrasonic transducers 22 are arranged at equal intervals and can form ultrasonic waves at multiple positions. Through the ultrasonic energy To promote dissolution or softening of thrombi. Among them, multiple ultrasonic transducers 22 form an ultrasonic working area, and the medical liquid outlet group is set corresponding to the ultrasonic working area. In the ultrasonic working area, the ultrasonic tube 2 forms ultrasonic vibration, so that the thrombolytic medicine discharged from the medical liquid outlet group The liquid can be atomized under ultrasonic vibration to form a smaller mist. The mist can better penetrate into the thrombus and improve the thrombolytic effect.
具体地，在本发明的一实施例中，超声波换能器22包括压电陶瓷片221、第一金属片222、第二金属片223和预紧螺栓224，第一金属片222和第二金属片223分别设置于压电陶瓷片221的两端，预紧螺栓224依次穿设于第一金属片222、压电陶瓷片221以及第二金属片223，第一金属片222与正极导线24电连接，第二金属片223与负极导线25电连接，通过驱动接头23将低频高能驱动电流传输至各超声波换能器22，在低频高能驱动电流的作用下，超声波换能器22的第一金属片222和第二金属片223对压电陶瓷片221的两端施加同频的交流电流，压电陶瓷片221在压电效应下发生低频振动并释放出超声波，超声波具有机械效应和空化效应，机械效应可以破坏血栓的结构，将血栓由紧密的纤维蛋白结构变为松散的纤维蛋白结构，有利于溶栓药物的渗透；空化效应可以使栓塞部位大量微气泡瞬间破裂，破坏血栓表面结构以溶解血栓。Specifically, in one embodiment of the present invention, the ultrasonic transducer 22 includes a piezoelectric ceramic sheet 221, a first metal sheet 222, a second metal sheet 223 and a preload bolt 224. The first metal sheet 222 and the second metal sheet Pieces 223 are respectively provided at both ends of the piezoelectric ceramic piece 221. The pre-tightening bolts 224 are sequentially penetrated through the first metal piece 222, the piezoelectric ceramic piece 221 and the second metal piece 223. The first metal piece 222 is electrically connected to the positive lead 24. connection, the second metal piece 223 is electrically connected to the negative lead 25, and the low-frequency high-energy driving current is transmitted to each ultrasonic transducer 22 through the driving connector 23. Under the action of the low-frequency high-energy driving current, the first metal of the ultrasonic transducer 22 The piece 222 and the second metal piece 223 apply an alternating current of the same frequency to both ends of the piezoelectric ceramic piece 221. The piezoelectric ceramic piece 221 vibrates at low frequency under the piezoelectric effect and releases ultrasonic waves. The ultrasonic waves have mechanical effects and cavitation effects. , the mechanical effect can destroy the structure of the thrombus, changing the thrombus from a tight fibrin structure to a loose fibrin structure, which is conducive to the penetration of thrombolytic drugs; the cavitation effect can instantly burst a large number of microbubbles at the embolization site, destroying the surface structure of the thrombus. to dissolve blood clots.
为了防止超声波换能器22相对超声管2移动，在本发明的一实施例中，声管的管壁向外凸起形成多个超声工作部26，超声工作部26呈圆筒状，超声工作部26的外径与溶栓套管1内腔的内径相等，使得超声管2与溶栓套管1滑动卡接。其中，每一超声波换能器22设于一超声工作部26内，以此固定各超声波换能器22相对超声管2的位置，保证超声溶栓正常进行。In order to prevent the ultrasonic transducer 22 from moving relative to the ultrasonic tube 2, in one embodiment of the present invention, the wall of the sound tube protrudes outward to form a plurality of ultrasonic working parts 26. The ultrasonic working parts 26 are cylindrical. The outer diameter of the portion 26 is equal to the inner diameter of the inner cavity of the thrombolysis cannula 1, so that the ultrasonic tube 2 and the thrombolysis cannula 1 are slidably engaged. Each ultrasonic transducer 22 is disposed in an ultrasonic working part 26 to fix the position of each ultrasonic transducer 22 relative to the ultrasonic tube 2 to ensure normal ultrasonic thrombolysis.
进一步地，在本发明的一实施例中，溶栓套管1包括药物释放导管11，转换接头3设于药物释放导管11的一端，定位导向部12设于药物释放导管11的另一端，定位导向部12的内腔与药物释放导管11的内腔连通，药物释放导管11靠近定位导向部12的一端设有药液出射孔组，药液出射孔组包括多个沿药物释放导管11的轴向方向线性分布的药液出射孔111，如此设置溶栓药液可以分别从多个药液出射孔111排出，有效扩大了溶栓药液的覆盖范围，提高溶栓效果。此外，自靠近药物释放导管11的一端至远离药物释放导管11的一端，定位导向部12的横截面积逐渐减小。Further, in one embodiment of the present invention, the thrombolysis cannula 1 includes a drug release catheter 11, the conversion joint 3 is provided at one end of the drug release catheter 11, and the positioning guide 12 is provided at the other end of the drug release catheter 11. The inner cavity of the guide part 12 is connected with the inner cavity of the drug release catheter 11. An end of the drug release catheter 11 close to the positioning guide part 12 is provided with a medical liquid outlet hole group. The medical liquid outlet hole group includes a plurality of axes along the drug release catheter 11. The thrombolytic liquid outlet holes 111 are arranged linearly in the direction. The thrombolytic liquid can be discharged from multiple liquid outlet holes 111 respectively, which effectively expands the coverage of the thrombolytic liquid and improves the thrombolytic effect. In addition, the cross-sectional area of the positioning guide 12 gradually decreases from an end close to the drug release conduit 11 to an end far away from the drug release conduit 11 .
更进一步地，在本发明的一实施例中，药物释放导管11的管壁开设有冷却通道112和药液注射通道113，冷却通道112和药液注射通道113均沿药物释放导管11的轴向延伸设置；冷却通道112设有多个，多个冷却通道112沿药物释放导管11的周向间隔分布；药液注射通道113设有多个，每一药液注射通道113设于相邻的两个冷却通道112之间。在本实施例中，冷却通道112为扇形且设置为四个，四个冷却通道112同时注入冷却液，能对药物释放导管11的多个位置进行冷却，保证冷却效果，并能容纳较更多的冷却液，保证冷却效率；药液注射通道113为圆形且设置为三个，同样的药液出射孔组设置为三个，每一药液出射孔组的多个药液出射孔111均与一药液注射通道113连通，以此溶栓药液可以从三个方向排出，进一步扩大了溶栓药液的覆盖范围，提高溶栓效果。Furthermore, in an embodiment of the present invention, the wall of the drug release catheter 11 is provided with a cooling channel 112 and a medical liquid injection channel 113. The cooling channel 112 and the medical liquid injection channel 113 are both along the axial direction of the drug release catheter 11. Extended arrangement; a plurality of cooling channels 112 are provided, and the plurality of cooling channels 112 are distributed at intervals along the circumference of the drug release conduit 11; a plurality of medical liquid injection channels 113 are provided, and each medical liquid injection channel 113 is provided on two adjacent between cooling channels 112. In this embodiment, the cooling channels 112 are fan-shaped and are provided with four. The four cooling channels 112 are injected with cooling liquid at the same time, which can cool multiple positions of the drug release conduit 11 to ensure the cooling effect and can accommodate more people. coolant to ensure cooling efficiency; the liquid injection channel 113 is circular and is set to three, the same liquid outlet group is set to three, and the multiple liquid outlet holes 111 of each liquid outlet group are It is connected with a medicinal solution injection channel 113 so that the thrombolytic medicinal solution can be discharged from three directions, further expanding the coverage of the thrombolytic medicinal solution and improving the thrombolytic effect.
可以理解的是，在溶栓过程中，由于溶栓药液持续释放出来，溶栓药液流速过大或流量过多都可能会引起血管内压力急剧升高，考虑到这一点，在本发明的一实施例中，肝癌栓塞术后股动脉血栓超声消融导管1000还包括压力传感器4，转换接头3上固定有导线引出接头33，压力传感器4固定设于定位导向部12上，压力传感器4的导线41穿过导线引出接头33。通过设置压力传感器4可以实时监测血管内压力，在压力过大时可以调节溶栓药液的流速和流量，以防止压力过高导致血管壁破裂，保证溶栓手术的顺利进行。压力传感器4为薄膜式压力传感器4，薄膜的微小弯曲能被准确地转换为电信号，以对血管内压力精确测量，且薄膜材料的特性使得传感器具有快速的响应速度，能实时监测血管内压力。It can be understood that during the thrombolysis process, due to the continuous release of the thrombolytic liquid, excessive flow rate or excessive flow of the thrombolytic liquid may cause a sharp increase in intravascular pressure. Taking this into account, in the present invention In one embodiment, the femoral artery thrombus ultrasonic ablation catheter 1000 after liver cancer embolization also includes a pressure sensor 4. A wire lead-out joint 33 is fixed on the conversion joint 3. The pressure sensor 4 is fixed on the positioning guide part 12. The pressure sensor 4 The conductor 41 passes through the conductor outlet connector 33 . By setting the pressure sensor 4, the intravascular pressure can be monitored in real time. When the pressure is too high, the flow rate and flow rate of the thrombolytic solution can be adjusted to prevent the vascular wall from rupturing due to excessive pressure and ensure the smooth progress of the thrombolysis surgery. The pressure sensor 4 is a membrane pressure sensor 4. The slight bending of the membrane can be accurately converted into an electrical signal to accurately measure the intravascular pressure. The characteristics of the membrane material allow the sensor to have a fast response speed and can monitor the intravascular pressure in real time. .
进一步地，在本发明的一实施例中，药物释放导管11的管壁还开设有传感器工作通道114，传感器工作通道114设于相邻的两个冷却通道112之间，传感器工作通道114贯穿药物释放导管11和定位导向部12，压力传感器4设于传感器工作通道114的通道口，并密封传感器工作通道114，压力传感器4的导线41穿过传感器工作通道114，如此设置可以在保证压力传感器4支撑工作的同时防止血液进入传感器工作通道114内。Further, in an embodiment of the present invention, the wall of the drug release conduit 11 is also provided with a sensor working channel 114. The sensor working channel 114 is provided between two adjacent cooling channels 112, and the sensor working channel 114 runs through the drug. Release the conduit 11 and the positioning guide 12. The pressure sensor 4 is located at the opening of the sensor working channel 114 and seals the sensor working channel 114. The wire 41 of the pressure sensor 4 passes through the sensor working channel 114. This arrangement can ensure that the pressure sensor 4 While supporting the work, blood is prevented from entering the sensor working channel 114.
为了使溶栓药液和冷却液分流至不同的药液注射通道113内和不同的冷却通道112内，在本发明的一实施例中，转换接头3包括药液分流接头34和冷却液分流接头35，药液分流接头34和冷却液分流接头35均为内部中空的环形圆柱结构，超声管2穿过药液分流接头34和冷却液分流接头35插入药物释放导管11。冷却液分流接头35的一端设有多个冷却液分流插头351，多个冷却液分流插头351均与冷却液分流接头35的内腔连通，每一冷却液分流插头351插接于一冷却通道112，冷却液分流接头35的另一端设有冷却液注入接口32，冷却液注入接口32与冷却液分流接头35的内腔连通，冷却液分流接头35开设有多个过孔352；药液分流接头34的一端设有传感器护管341和多个药液分流插头342，传感器护管341穿过一过孔352插接于传感器工作通道114，多个药液分流插头342均与药液分流接头34的内腔连通，每一药液分流插头342穿过一过孔352插接于一药液注射通道113，药液分流接头34的另一端设有溶栓药物注入接口31和导线引出接头33，溶栓药物注入接口31与药液分流接头34的内腔连通，导线引出接头33与传感器护管341连通，药液分流接头34开设有冷却液注入接口孔343，冷却液注入接口32穿设于冷却液注入接口孔343。在本实施例中，冷却液分流插头351对应冷却通道112设置为四个，药液分流插头342对应药液注射通道113设置为三个，过孔352设置为四个，四个过孔352分别用于供传感器护管341和三个药液分流插头342穿过，以此溶栓药物可以从溶栓药物注入接口31进入药液分流接头34的内腔，然后通过三个药液分流插头342分流至三个药液注射通道113内，最后通过各药液注射通道113上的药液出射孔111排出；冷却液通过冷却液注入接口32进入冷却液分流接头35的内腔，然后通过四个冷却液分流插头351分流至四个冷却通道112中；压力传感器4的导线41先穿过传感器工作通道114，然后穿过传感器护管341，最后从导线引出接头33引出与数据传输接头5连接。In order to divert the thrombolytic liquid and cooling liquid to different liquid injection channels 113 and different cooling channels 112 , in one embodiment of the present invention, the conversion joint 3 includes a liquid branching joint 34 and a cooling liquid branching joint. 35. The medical liquid shunt joint 34 and the coolant shunt joint 35 are both annular cylindrical structures with hollow interiors. The ultrasonic tube 2 passes through the medical liquid shunt joint 34 and the coolant shunt joint 35 and is inserted into the drug release conduit 11 . One end of the coolant diverter joint 35 is provided with a plurality of coolant diverter plugs 351. The plurality of coolant diverter plugs 351 are all connected with the inner cavity of the coolant diverter joint 35. Each coolant diverter plug 351 is plugged into a cooling channel 112. , the other end of the coolant shunt joint 35 is provided with a coolant injection interface 32. The coolant injection interface 32 is connected with the inner cavity of the coolant shunt joint 35. The coolant shunt joint 35 is provided with a plurality of through holes 352; the medicine liquid shunt joint One end of 34 is provided with a sensor protective tube 341 and a plurality of medical liquid shunt plugs 342. The sensor protective tube 341 passes through a through hole 352 and is plugged into the sensor working channel 114. The plurality of medical liquid shunt plugs 342 are all connected to the medical liquid shunt connector 34. The inner cavity of the liquid shunt connector 342 is connected to a medical liquid injection channel 113 through a through hole 352. The other end of the medical liquid shunt connector 34 is provided with a thrombolytic drug injection interface 31 and a wire lead-out connector 33. The thrombolytic drug injection interface 31 is connected to the inner cavity of the medicine liquid shunt joint 34, the wire lead-out joint 33 is connected to the sensor protective tube 341, the medicine liquid shunt joint 34 is provided with a coolant injection interface hole 343, and the coolant injection interface 32 is installed in Coolant is injected into the interface hole 343. In this embodiment, there are four cooling liquid shunt plugs 351 corresponding to the cooling channels 112 , three medical liquid shunt plugs 342 corresponding to the medical liquid injection channels 113 , four through holes 352 , and the four through holes 352 are respectively It is used for the sensor protective tube 341 and the three medicine liquid shunt plugs 342 to pass through, so that the thrombolytic medicine can enter the inner cavity of the medicine liquid shunt connector 34 from the thrombolytic medicine injection interface 31, and then pass through the three medicine liquid shunt plugs 342 The coolant is diverted to three liquid injection channels 113 and finally discharged through the liquid outlet hole 111 on each liquid injection channel 113; the coolant enters the inner cavity of the coolant shunt joint 35 through the coolant injection interface 32, and then passes through four The coolant shunt plug 351 branches to four cooling channels 112; the wire 41 of the pressure sensor 4 first passes through the sensor working channel 114, then passes through the sensor protective tube 341, and finally is led out from the wire lead-out connector 33 and connected to the data transmission connector 5.
为了能定位溶栓套管1的位置，在本发明的一实施例中，溶栓套管1靠近定位导向部12的一端设有金属定位圈13，在具体使用时，可以通过X线透视图观察金属定位圈13的位置，以此确定溶栓套管1的插入位置。In order to locate the position of the thrombolysis cannula 1, in one embodiment of the present invention, a metal positioning ring 13 is provided at one end of the thrombolysis cannula 1 close to the positioning guide 12. During specific use, the X-ray perspective view can be used to determine the position of the thrombolysis cannula 1. Observe the position of the metal positioning ring 13 to determine the insertion position of the thrombolysis cannula 1.
本肝癌栓塞术后股动脉血栓超声消融导管1000的一个使用方法为：首先使用介入导丝对股动脉进行穿刺，在X线的辅助下，介入导丝穿刺至股动脉血栓部位，然后将溶栓套管1设有定位导向部12的一端沿介入导丝穿刺进入股动脉中，由于溶栓套管1靠近定位导向部12的一端固定有金属定位圈13，通过X线透视图观察金属定位圈13的位置，在金属定位圈13到达介入导丝前端时，停止溶栓套管1的穿刺，此时撤出介入导丝，将超声管2沿溶栓套管1的内腔插入，直至超声管2的定位凸起21进入与之匹配的定位导向部12中，此时超声管2的超声工作部26和药液出射孔111均位于股动脉血栓区间中；随后将装载有溶栓药液的微量注射泵与溶栓药物注入接口31相连接，将装载有冷却液的注射设备与冷却液注入接口32连接，将超声管2的驱动接头23接到低频高能超声波发生器上，同时将压力传感器4的数据传输接头5接入到监控主机上，在各个线路连接完毕后，打开微量注射泵、冷却液注射设备、低频高能超声波发生器和监控主机后，微量注射泵将溶栓药液注入到药液分流接头34中，溶栓药液将从不同的药液分流插头342进入到药液注射通道113中，而溶栓药液在超声管2的超声振动雾化下形成颗粒更小的药雾，药雾和药液的混合物从药液出射孔111中扩散出来作用于血栓。One method of using the femoral artery thrombus ultrasonic ablation catheter 1000 after liver cancer embolization is: first use an interventional guidewire to puncture the femoral artery, with the assistance of One end of the cannula 1 is provided with a positioning guide 12 and is punctured into the femoral artery along the interventional guide wire. Since the end of the thrombolysis cannula 1 close to the positioning guide 12 is fixed with a metal positioning ring 13, the metal positioning ring 13 can be observed through X-ray perspective. 13, when the metal positioning ring 13 reaches the front end of the interventional guidewire, stop the puncture of the thrombolysis cannula 1, withdraw the interventional guidewire at this time, and insert the ultrasonic tube 2 along the inner cavity of the thrombolysis cannula 1 until ultrasound The positioning protrusion 21 of the tube 2 enters the matching positioning guide part 12. At this time, the ultrasonic working part 26 and the liquid exit hole 111 of the ultrasonic tube 2 are located in the femoral artery thrombus interval; then the thrombolytic liquid will be loaded The micro-injection pump is connected to the thrombolytic drug injection interface 31, the injection equipment loaded with coolant is connected to the coolant injection interface 32, the driving joint 23 of the ultrasonic tube 2 is connected to the low-frequency high-energy ultrasonic generator, and at the same time, the pressure The data transmission connector 5 of the sensor 4 is connected to the monitoring host. After each line is connected, the micro-injection pump, coolant injection equipment, low-frequency high-energy ultrasonic generator and monitoring host are turned on. The micro-injection pump injects the thrombolytic solution In the medical solution shunt connector 34, the thrombolytic solution will enter the medical solution injection channel 113 from different medical solution shunt plugs 342, and the thrombolytic solution will form smaller particles under the ultrasonic vibration atomization of the ultrasonic tube 2 The mixture of medical mist and medical liquid diffuses from the liquid outlet hole 111 and acts on the thrombus.
超声管2在接收到低频高能驱动电流后，内部的超声波换能器22的第一金属片222和第二金属片223将对压电陶瓷片221两端施加同频的交流电流，此时压电陶瓷片221在压电效应下发生低频振动并释放处超声波，而超声波具有机械效应、弥散作用和空化效应，机械效应作用于血栓的时候，可以把血栓由一个紧密的纤维蛋白结构变为松散的纤维蛋白结构，这样就有利于溶栓药物的渗透；一定剂量的超声，可以提高细胞半透膜的渗透作用；当超声波的空化效应作用于血栓，可以使栓塞部位大量微气泡瞬时破裂，破坏血栓表面结构，达到溶解目的。After the ultrasonic tube 2 receives a low-frequency high-energy driving current, the first metal sheet 222 and the second metal sheet 223 of the internal ultrasonic transducer 22 will apply an alternating current of the same frequency to both ends of the piezoelectric ceramic sheet 221. At this time, the pressure The electric ceramic sheet 221 vibrates at low frequency under the piezoelectric effect and releases ultrasonic waves. Ultrasonic waves have mechanical effects, diffusion effects and cavitation effects. When the mechanical effects act on thrombi, they can change the thrombus from a tight fibrin structure into The loose fibrin structure is conducive to the penetration of thrombolytic drugs; a certain dose of ultrasound can improve the permeability of the cell semipermeable membrane; when the cavitation effect of ultrasound acts on the thrombus, a large number of microbubbles at the embolization site can be instantly ruptured , destroy the surface structure of thrombus and achieve dissolution.
由于超声波的低频高能特性，超声波持续溶栓时，应对溶栓套管1进行降温，防止温度过高而造成正常流动的血液发生变性，此时可利用溶栓套管1的冷却通道112进行降温，向冷却通道112中注入冷却液然后在抽吸出来，以一定频率使得注入和抽吸交替进行，从而带走低频高能超声波工作所产生的过多热量。Due to the low-frequency and high-energy characteristics of ultrasonic waves, when ultrasonic waves continue to dissolve thrombosis, the thrombolysis sleeve 1 should be cooled to prevent the temperature from being too high and causing the normal flowing blood to denature. At this time, the cooling channel 112 of the thrombolysis sleeve 1 can be used to cool down. , inject coolant into the cooling channel 112 and then pump it out, alternating injection and pumping at a certain frequency, thereby taking away excess heat generated by low-frequency high-energy ultrasonic operation.
在药物溶栓联合超声溶栓过程中，由于溶栓药液持续释放出来，溶栓药液流速过大或流量过多会引起血管内压力急剧升高，压力传感器4可实施监测血管内压力，为了防止压力过高导致血管壁破裂，在压力过大时应调节溶栓药液的流速和流量，保证溶栓手术的顺利进行。During the process of drug thrombolysis combined with ultrasonic thrombolysis, due to the continuous release of the thrombolytic solution, excessive flow rate or excessive flow of the thrombolytic solution will cause a sharp increase in intravascular pressure. The pressure sensor 4 can monitor the intravascular pressure. In order to prevent excessive pressure from causing rupture of the blood vessel wall, the flow rate and flow rate of the thrombolytic solution should be adjusted when the pressure is too high to ensure the smooth progress of the thrombolytic surgery.
以上所述仅为本发明的优选实施例，并非因此限制本发明的专利范围，凡是在本发明的发明构思下，利用本发明说明书及附图内容所作的等效结构变换，或直接/间接运用在其他相关的技术领域均包括在本发明的专利保护范围内。The above are only preferred embodiments of the present invention, and do not limit the patent scope of the present invention. Under the inventive concept of the present invention, equivalent structural transformations can be made using the contents of the description and drawings of the present invention, or direct/indirect applications. Other related technical fields are included in the patent protection scope of the present invention.
| Application Number | Priority Date | Filing Date | Title |
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| CN202311138681.3ACN116983050A (en) | 2023-09-01 | 2023-09-01 | Femoral artery thrombus ultrasonic ablation catheter after liver cancer embolism operation |
| Application Number | Priority Date | Filing Date | Title |
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| CN202311138681.3ACN116983050A (en) | 2023-09-01 | 2023-09-01 | Femoral artery thrombus ultrasonic ablation catheter after liver cancer embolism operation |
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| CN202311138681.3AWithdrawnCN116983050A (en) | 2023-09-01 | 2023-09-01 | Femoral artery thrombus ultrasonic ablation catheter after liver cancer embolism operation |
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| CN117322957A (en)* | 2023-12-01 | 2024-01-02 | 深圳腾复医疗科技有限公司 | Ultrasonic ablation circuit and device comprising same |
| CN117860342A (en)* | 2024-03-08 | 2024-04-12 | 上海佳沐垚医疗科技有限公司 | Suction ultrasonic recanalization catheter system |
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN117322957A (en)* | 2023-12-01 | 2024-01-02 | 深圳腾复医疗科技有限公司 | Ultrasonic ablation circuit and device comprising same |
| CN117322957B (en)* | 2023-12-01 | 2024-02-06 | 深圳腾复医疗科技有限公司 | Ultrasonic ablation circuit and device comprising same |
| CN117860342A (en)* | 2024-03-08 | 2024-04-12 | 上海佳沐垚医疗科技有限公司 | Suction ultrasonic recanalization catheter system |
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